All posts by medical

Paul Meakin – The Conversation UK

2020

Elevated circulating amyloid promotes concentrations in obesity and diabetes promote vascular dysfunction. , Journal of Clinical Investigation

2018

Small vessels, dementia and chronic diseases molecular mechanisms and pathophysiology. , Clinical Science

2018

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice. , Scientific Reports

2018

The beta secretase BACE1 regulates the expression of the insulin receptor in the liver. , Nature Communications

2018

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of Keap1, Nature

2018

The BACE1 product sAPP induces ER stress, inflammation and attenuates insulin signaling in skeletal muscle. , Metabolism

2016

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation., Scientific Reports

2015

Beta2-integrin knock-in mice remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation. , PLoS One

2015

Neuronal development is promoted by weakened intrinsic antioxidant defenses due to epigenetic repression of Nrf2, Nature Communications

2015

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1b production via NRF2-mediated counter-regulation of the inflammasome., Journal of Autoimmunity

2014

The susceptibility of Nrf2-null mice to hepatic steatosis and cirrhosis upon consumption of a high-fat diet is associated with a profound disturbance in metabolic enzymes in the liver, but not with insulin resistance. , Journal of Cell Biology

2014

Antioxid Redox Phosphoinositide 3-kinases upregulate system xc- via eIF2 and ATF4 a pathway active in glioblastomas and epilepsy. , Antioxidant & Redox Signaling

2014

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes. , PNAS

2014

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes. , Diabetologia

2013

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression. , Neurosignals

2011

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. , Biochemical Journals

2010

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. , Free Radical Biology and Medicine

2010

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the down-regulation of protein synthesis. , American Journal of Physiology-Endocrinology and Metabolism

2007

Fructose metabolism in the adult mouse optic nerve, a central white matter tract. , Journal of Cerebral Blood Flow & Metabolism

2006

Fructose supports energy metabolism of some, but not all, axons in adult mouse optic nerve. , Journal of Neurophysiology

Continued here:
Paul Meakin - The Conversation UK

Preparation is key when returning to exercise after lockdown – Mirage News

With the resumption of full training activities and competitions for community sport this week, there are concerns about the risk of injury from people increasing their exercise loads too quickly.

While the beginning of lockdown saw an explosion of participation in online exercise classes and local parks filled with people completing their daily exercise, as restrictions eased, so did many peoples workout routines.

Lecturer in Exercise Physiology at UNSW Medicines School of Medical Sciences, Dr Mandy Hagstrom believes the risk of injury can be minimised by resuming training in the right manner.

If exercise is commenced gradually, then the risk of injury is minimal, she says.

The risk comes when people jump straight back into high volumes of physical activity when they havent been doing much for a while.

With delayed starts to sporting seasons, many people may be tempted to jump straight back into training at full intensity, hoping to make up as much ground as possible. But Dr Hagstrom recommends a more measured approach.

Start with less days per week, less time in the given activity, and perhaps at a slightly easier intensity than previously accustomed, she says.

You will be able to gauge how your body is going after a few sessions and increase as you can tolerate.

Its completely normal for people to feel a sense of fatigue and soreness when returning to activity, and equally as important for them to realise that these feelings will diminish over time with consistency in their routines.

Personal trainers can provide professional advice and guidance for people who are concerned about returning to exercise. Photo: UNSW Fitness & Aquatic Centre

Jack Burke, Health and Fitness Coordinator at UNSW Fitness and Aquatic Centre agrees, urging people to be kinder to themselves as they return to exercise.

For the vast majority of people, returning to exercise means not being in the same condition as pre-COVID, but you are not alone! he says.

Dont beat yourself up about coming back a little underdone in these unprecedented times. Stay positive, enjoy the feeling of exercise again and being back in the gym.

Dr Hagstrom also emphasises preparation as a key element of returning to training and exercise.

You can help prepare mentally, as well as physically, by planning out when you think you will exercise, she says.

What time of day will it be? What do you need to prepare beforehand? For example, do you need to pack breakfast to have at work? How many times are you going to try and exercise per week? Set yourself goals, but make sure they are achievable.

As for coaches and trainers working with large groups, Dr Hagstrom highlights that it is important to recognise that everyone will have been working at different levels during their time away from exercise.

People of different training backgrounds will be able to resume activity at different speeds, she says.

Dr Mandy Hagstrom emphasises the need for people to understand their own fitness levels and limits as they return to training.

Most people who were highly active, or competitive, will have managed to remain active even if its not in a manner that they were previously accustomed to and as such, they will likely be back to more normal routines sooner than others.

Those individuals who have been truly sedentary will have a much lower tolerance to exercise initially, however, these people will also make excellent results in the initial part of their program.

As with anything exercise prescription-related, individualisation is key, regardless of level.

For those who are concerned about their level of fitness and potentially sustaining an injury, Dr Hagstrom recommends consulting with a professional.

That may be a personal trainer, or an exercise physiologist if you have specific concerns related to your health and exercising, she says.

There wont be any judgement, and the professionals are here to help you achieve your goals.

More:
Preparation is key when returning to exercise after lockdown - Mirage News

NYC Nurse Thanks Fellow Heroes at Ascension Saint Thomas Rutherford – rutherfordsource.com

Trinette Lewis is a New York City nurse who pursued the profession because she loved studying anatomy and physiology and wanted to apply that knowledge in a tangible way. She says that her appreciation for her career has evolved in recent months, explaining: Once the pandemic began, I realized that nursing is more than a profession. Its a calling; its a movement, and its a beautiful expression of love.

Trinette has been working tirelessly on the front lines at Lenox Hill Hospital on the Upper East Side of Manhattan. Earlier this month, she had the opportunity to take a much-deserved break to visit her mom in Murfreesboro. Though it would have been understandable if Trinette had used her vacation time to relax, she had something else in mind. I wanted to show appreciation to the nurses at Ascension Saint Thomas Rutherford because they have selflessly helped treat my grandmother, brother, and sister over the years, says Trinette. While Im far away in New York City, I am very grateful that I can trust Ascension Saint Thomas to care for my family when they are sick.

Determined to express thanks for Murfreesboros hard-working caregivers, Trinette and her mom delivered glazed donuts, hot coffee, and handmade prayer cards to the nursing staff. Trinette calls her gesture a small token of gratitude for the big ways nurses have helped our nation rise above this pandemic. To the nurses at Ascension Saint Thomas Rutherford, however, Trinettes gift was anything but small.

Trinette is now safely back at work in New York City.

See the rest here:
NYC Nurse Thanks Fellow Heroes at Ascension Saint Thomas Rutherford - rutherfordsource.com

New Study Confirms COVID-19 Vaccine Will Need to Elicit T Cells to Work alongside Antibodies – HospiMedica

Image: Dr. Alessandro Sette and Dr. Daniela Weiskopf (Photo curtesy of La Jolla Institute for Immunology)

The study conducted by researchers at La Jolla Institute for Immunology (LJI La Jolla, CA, USA) and Erasmus University Medical Center (Rotterdam, Netherlands) also revealed that both Dutch and American patients have similar responses to the virus. For the study, the researchers followed 10 COVID-19 patients with the most severe disease symptoms who were put on ventilators out of which two patients eventually died of the disease. An in-depth look at their immune system responses showed that all the 10 patients produced T cells that targeted the SARS-CoV-2 virus. These T cells worked alongside antibodies to try to clear the virus and stop the infection.

These findings are in line with a recent study that showed a robust T cell response in individuals with moderate cases of COVID-19. In both the studies, the T cells in these patients prominently targeted the spike protein on SARS-CoV-2. The virus uses the spike protein to enter host cells, and most vaccine efforts around the world are aimed at getting the immune system to recognize and attack this protein. The new study offers further evidence that the spike protein is a promising target and confirms that the immune system can also mount strong responses to other targets on the virus.

This is key to understanding how the immune response fights the virus, said LJI Professor Alessandro Sette, Dr. Biol. Sci., who co-led the study with Erasmus MC Virologist Rory de Vries, Ph.D. You want vaccine approaches to be grounded in observations from rather diverse settings to ensure that the results are generally applicable.

Activating these cells appears to be at least as important as the production of antibodies, says Erasmus MC Virologist Rory de Vries, Ph.D., who co-led the study with Sette.

Related Links:La Jolla Institute for Immunology Erasmus University Medical Center

Originally posted here:
New Study Confirms COVID-19 Vaccine Will Need to Elicit T Cells to Work alongside Antibodies - HospiMedica

Cancer Immunology And Oncolytic Virology Market to Exhibit Rapid Surge in Consumption in the COVID-19 Crisis – Cole of Duty

The global cancer immunotherapy market should reach $96.5 billion by 2021 from $73.0 billion in 2016 at a compound annual growth rate (CAGR) of 5.7%, from 2016 to 2021.

Report Scope:

The scope of this report coverscurrent cancer immunotherapymarkets for most common cancers. The market segments included in this report are therapeutic monoclonal antibodies (with special focus on checkpoint inhibitors), synthetic interleukins, interferons, and colony-stimulating factors; small kinase inhibitors of cancer-related targets; protective and therapeutic cancer vaccines; and adoptive cell therapies. This report also covers treatments that are in development for late-stage and early-stage oncolytic viruses. Detailed epidemiological information, discussion of incidence and mortality trends, overview of regulatory landscapes, and analysis of market shares for leading products and companies are also included in this report.

Request For Report[emailprotected]https://www.trendsmarketresearch.com/report/sample/11805

Report Includes:

An overview of the global markets for cancer immunotherapies and oncolytic virology. Analyses of global market trends, with data from 2015, 2016, and projections of compound annual growth rates (CAGRs) through 2021. Analyses of factors influencing market demand, such as clinical guidelines, demographic changes, and market saturation. Information covering the latest trends, market structure, market size, key drug segments, and trends in technology. Coverage of colony stimulating factors (CSFs), interferon alfa and gamma products, interleukin products and therapeutic monoclonal antibodies, including antibody conjugates, cancer vaccines, and other cancer treatment immunology products. Technological discussions, including the current state, newly issued patents, and pending applications. Profiles of leading companies in the industry.

Report Summary

Cancer is a disease with global implications. There are many different types of cancer, of which the most common types include lung, breast, colon and rectal, stomach, head and neck, prostate, cervical, melanoma, and ovarian cancer, as well as leukemia. Cancer is a genetic disease that is conventionally treated by surgery, radiation therapy, chemotherapy, hormonal therapy, and immunotherapy. Surgery is the mainstay treatment for all cancers. Usually surgery is complimented with radiation or chemotherapy to ensure the clearance of all residual cancer. Despite the advances in treatment, cancer has great plasticity; therefore, after a certain time the effects of treatment fade and cancer returns with acquired resistance. Combination therapy, using multiple modalities including surgery and pharmaceutical or radiation therapy, improves response to treatment.

Radiation and chemotherapy have many side effects. Biological treatment options provide less impactful treatment of cancer. Immunotherapy is a type of biological therapy and it incorporates elements of the immune system in cancer treatment. The immune system has various types of cells and proteins that detect and act upon signs of a disease or infection by harmful and foreign substances such as microbes, bacteria and viruses. The immune system differentiates the bodys own cells and tissues through an evolutionary bar-coding system. This system helps the immune system understand encountered foreign substances as nonself. Cancer cells are recognized as nonself as well. The immune system monitors the body for cancer and destroys when it detects a malignancy. Cancer cells can avoid being recognized by the immune system and develop resistance through numerous methods.

Get Complete TOC with Tables and [emailprotected]https://www.trendsmarketresearch.com/report/discount/11805

Since the early 1900s, the connection between cancer and the immune system has caught the attention of various scientists and medical practitioners. Although the early studies were bluntly done without current technological and scientific tools, they nonetheless shed insights leading to the development of the first monoclonal antibodies and to the use of biologically derived synthetic interleukins and interferons. After many decades of research, immunotherapy finally emerged as a fully functionalclinical area in the 1990s. Since then, the cancer therapeutics landscape has changed dramatically.

With the stream of product approvals in recent years, the global immunotherapy market has reached its current value. In 2015, the global cancer immunotherapy market hit $65 billion. The current immunotherapy market contains several blockbuster products reaching their end-of-market exclusivities; however, the market is mostly comprised of newly introduced and expensive therapies. In 2016, the market expanded by more than 10% over the previous year, reaching $73 billion. During the period of 2016 through 2021, the global cancer immunotherapy market is forecast to grow by a 5.7% compound annual growth rate (CAGR), reaching $96.5 billion in 2021.

<<< Get COVID-19 Report Analysis >>>https://www.trendsmarketresearch.com/report/covid-19-analysis/11805

The strongest growth is expected to occur in checkpoint-inhibitor drugs with a 19.4% CAGR during the forecast period. Immunomodulators are anticipated to show the second-highest growth rates among immunotherapy products, with an 8.4% CAGR during the same period. The combined sales from both segments are expected to make up for nearly one-third of the market, with a combined sales value of $28 billion in 2021. Checkpoint inhibitors are virtually comprised of monoclonal antibodies; however,they are assessed separately due to their immense commercial and clinical significance. Sales from other therapeutic antibodies accrued to $28 billion in 2016, and this value is expected to remain relatively constant through 2021, due to several patent expiries, pressure from anticipated generic entries, and newly introduced classes of drugs expected by 2021.

Here is the original post:
Cancer Immunology And Oncolytic Virology Market to Exhibit Rapid Surge in Consumption in the COVID-19 Crisis - Cole of Duty

Government Invests 4.8m into Trinity-Led Coronavirus Research Hub – The University Times

Molly FureyDeputy Editor

The government has invested 4.8 million into a Trinity-led research hub looking into why some people are more susceptible to the coronavirus than others.

The government will be funding the partnership led by Prof Kingston Mills at the Trinity Biomedical Sciences Institute (TBSI) and Prof Aideen Long at the Trinity Translational Medicine Institute (TTMI) through Science Foundation Ireland.

In a press statement today, Minister for Higher Education Simon Harris said that he was delighted to establish the research partnership with Trinity.

Science and research have never been more important as the world faces a global pandemic. We still have so much more to learn about this virus and this partnership will be key to addressing some of the key questions, he said.

Harris added that the Trinity-led research would be of national importance given the immense societal and economic impact of the current pandemic and will enable us to contribute solutions to the challenges we face.

The 4.8 comes in addition to the 2.4 million committed by AIB back in April to establish a coronavirus research hub in Trinity. The research will seek to understand why some people are more susceptible to coronavirus than others in order to accelerate the process by which individuals can be identified as immune and therefore safe to return to work.

In a press statement, Prof Mill welcomed the development and said that the funding has allowed the creation of a centre of excellence in the Immunology of COVID-19.

The funding, he said, would allow Trinitys researchers to address key research questions designed to tackle the COVID-19 pandemic and that the research could help in the development of a coronavirus vaccine.

The longer-term objective is to create a national research centre focused on the immunology of infection that will enable Ireland to be poised and better prepared, with the appropriately skilled and coordinated scientific and medical expertise, to deal with other infectious disease epidemics in the future, Mill added.

In a tweet announcing the partnership, Provost Patrick Prendergast said that the importance of fundamental science [was] never more obvious.

Trinity will lead the project in collaboration with researchers at University of Limerick and University College Dublin, and will work in conjunction with international collaborators in America, the Netherlands, France, Hong Kong and the UK.

More:
Government Invests 4.8m into Trinity-Led Coronavirus Research Hub - The University Times

UK’s IVF success rate has tripled in last 20 years – The Guardian

IVF success rates have tripled over the last 20 years in the UK, with almost a third of all embryo transfers in women under 35 resulting in a baby, according to the fertility regulator.

But patients in parts of England are finding it increasingly difficult to access NHS funding for infertility treatment due to what one expert described as a hugely disappointing fall in NHS-funded cycles. Though UK guidelines say women under 40 should be given three full IVF cycles, that only happens by default in Scotland, where 60% of treatments were NHS funded in 2018, statistics from the Human Fertilisation and Embryology Authority (HFEA) show.

In England, where funding is decided by local clinical commissioning groups (CCGs), there is a postcode lottery, with just some offering three cycles and others none. Many CCGs have reduced funding for fertility treatment, with the biggest decreases seen in the east of England as well as Yorkshire and the Humber, cutting the England-wide share of NHS funded cycles to 35% from 41% in 2013.

The chances of IVF succeeding has improved across all age groups since 1998, though younger women continue to have a far higher birth rate. In 2018, the average birth rate per embryo transferred for all IVF patients was 23% but was 31% for under-35s, compared with less than 5% for patients 43 and above when using their own eggs.

Women over 40 who use donor eggs rather than their own have a much higher chance of a baby 25% per embryo transfer, compared with 10% when using their own eggs.

Since 2013, the number of egg and embryo storage cycles increased fivefold to just under 9,000 cycles in 2018, as freezing techniques improved and have become more commonplace.

Frozen embryo transfers are now more successful than fresh transfers, with 24.8% resulting in a baby (the birth rate from fresh transfers is 22.7%). Doctors increasingly freeze all embryos from each IVF cycle, not just the spares, giving a womans body more time to get back to normal after the physically arduous process of ovarian stimulation.

Black and minority ethnic women in the UK are more likely to turn to IVF the figures show. Just 59% of all IVF cycles in 2018 were undertaken by white people, who make up an estimated 86% of the UK population as a whole.

Prof Adam Balen, the Royal College of Obstetricians and Gynaecologists spokesperson on reproductive medicine, welcomed the increased birth rates but criticised the reduction in funding, saying IVF should not be an easy target for cost cutting.

What is hugely disappointing is the continued fall in NHS-funded cycles. In 2018 in Scotland, 60% of treatment was NHS-funded, compared to 45% in Northern Ireland, 41% in Wales and 35% in England, he said.

Whilst the Nice [National Institute for Health and Care Excellence] guidance states that all eligible couples should be entitled to three full cycles (including the use of frozen embryos) and we know, using latest statistics, that this will give them an 80-85% chance of having a baby and indeed many will not require the full three cycles, with on average 30% conceiving with one cycle (and in the best cases maybe 40-45%) IVF is seen to be an easy target.

But infertility is a serious medical condition, resulting in huge stress and distress and caused itself by a large number of different medical problems. Indeed, it is the second commonest reason for women of reproductive years to visit their GP. IVF is cost effective and has shown to be an economic benefit to society.

Though IVF has traditionally been associated with twins, the multiple birth rate from the procedure has decreased to 8%, its lowest level since 1991, when the rate was 29.1%. This follows research proving that implanting more than one embryo does not result in a better chance of having a baby.

Implanting more than one embryo has no significant impact on the chance of a live birth but results in a 32% multiple birth rate for patients under 35.

Sally Cheshire, chair of the HFEA, said this reduction made pregnancy and childbirth much safer for women and babies.

I am delighted that we have continued to make progress on reducing the multiple birth rate, making fertility treatment now safer than ever before. We know that multiple births are the biggest single health risk from IVF for mothers and babies and put an additional burden on the NHS.

Thats why it is a great achievement that for the first time our 10% multiple birth rate target was achieved across all age groups and nationally only 8% of IVF births resulted in a multiple birth. This shows that there is now a common understanding that implanting more than one embryo does not increase your chances of having a baby.

Read the rest here:
UK's IVF success rate has tripled in last 20 years - The Guardian

Opinion: Commentary: Moving Forward: The Anatomy of Racism in our Everyday Lives – Virginia Connection Newspapers

In the past few weeks, many people, especially African Americans, have had to reconcile what they have seen in witnessing the murder of George Floyd and that of their own experience. I am no exception.

I have lived long enough to wipe away many tears of frustration in moments that simply did not recognize or appreciate our humanity. Whether it was in my new elementary school, where I became the first black girl in the class, and the teachers stood behind me in amazement because they did not expect me to exhibit logical thought. Or, as a mother who fiercely protected her kids. Or in every workplace I have encountered. The root was always the same: racism.

Racism, or the R word, can become a hideous tool that acknowledges a structure kept in place to maintain control and dominance of another. I have seen both the masterful and the novice attempt to use R as a weapon to steer the actions of others and/or to demean me, or sometimes both. Whether I was walking my sons bike home in my neighborhood so that he could stay to have a sleepover; or, conducting a campaign during an election; or, working to protect children; or in the Boardrooms' the truly crafty find this tool handy.

I dont always speak about it, but I do see it and I respond when I believe the action I am experiencing is so cruel that it resembles that of an overseer who demands compliance. This is not an accusation of every person I have met, but the widespread presence of racism is a stain to this democracy and to the life experience of many in my community. I have been patient and collaborative. I have had hard discussions with folks, some fruitful and some not. Now it is time to simply diagram what a life in a society where racism has not been eradicated really looks like. It is a conversation starter. We need to face R and we need to take affirmative steps to do something about it.

Growing Intolerance for the Manifested Character of Racism

I, like many others, have grown intolerant of the structures founded on racismthat belief that allows us to treat others differently, to feel superior or to dominate and oppress another with a self-righteous justification. The R can be comprised of aggressive or passive aggressive acts, even micro-aggressive acts, as R comes in many forms. For some, it is revealed in overt murderous acts or for the more subtle, manipulative acts that use code words that allude to race without ever having to mention the word. For the truly sophisticated, it shows up in delay tactics, calls for comfort to naysayers, or an attempt to find the right person for the job. Oh, and my favorite, lets pit blacks in this workspace against one another because after all, we only need one.

My intolerance is a response to a system of actions with a 400-plus year history in this nation. The systems of Racism were installed when a few profiteers acted on the belief that human trafficking, combined with uncompensated work, was a worthwhile business. Slavery doesnt belong to Blacks, as it has been a worldwide practice. While slavery has been abolished in the U.S., its hideous remnants remain. So here you will find a few more characteristics and scenarios that help identify the trappings of this diabolical weapon.

More Details on What R Looks like

Racism is always something that is expected to create a structure of power. It is often practiced in secret and sometimes those who witness it become complicit. For some, there is an inherent need to be a part of the powerful and not the powerless. Others can become complicit by being unaware of past practices or a culture. Racism is always a form of bullying, because it is a way to whip another person(s) into submission. Racism can also occur amongst those who genuinely want to do the right thing, but are less familiar with this tactic. It is often masked as a pending question, where theres an effort to achieve the right fit or find the best person for the job. The word racism itself is rarely used in these situations.

When It Appears

I was in first grade when I realized that racism would be a part of the tapestry of my life. I was playing in front of my new house with my brother. A little girl stood at the end of her driveway and just looked at me and my brother. I invited her to join us. Her response was, My daddy doesnt allow me to play with people like you. I kept playing; after all, I was with my brother, she was alone. Later, I learned that she was the daughter of a police officer. My mother, who was masterful in being a strong woman who determined her own path, told me that some people have a problem, but to never let their problem become your problem. I still live by those words. She also raised me with what some might call good home training. I learned that I would be judged, but not to internalize, that I must keep my composure, to speak enough words to get my point across and to never waste energy on those who create distractions and eat up my time. All actions do not require a reaction but I would learn the difference. But back to that intolerance

Racism Always Expects a Culture of Tolerance

In my mothers generation, society expected a well-behaved Negro. This term referred to the dignified person who did not crack under pressure. The well-behaved Negro protested and didnt fight back; sat at the counter while being spat upon; went to the work place worked hard and was passed over for promotions; and endured code language that demeaned the quality of their work and/or pitted blacks against one another for the same job. After all, we only need one black person to look like its not R, right? It is the culture of the well-behaved Negro that taught black parents to teach their kids to obey the police, to keep their hands on the wheel, to speak politely these are all the lessons of the well-behaved Negro. Emmett Till was killed because he was accused of violating the silent code of the well-behaved Negro.

After the Civil War, the KKK scourged this nation by sowing seeds of fear through threat, lynching and other forms of violence to enforce the code of the well-behaved Negro. This code also tells Black folk to stay in their place or face a penalty that most times was not addressed by law enforcement. In 1921 in Tulsa, Ok, we saw the burning of Black Wall Street part of a trend in several cities where countless murders occurred because those folks violated the code. Implicitly, the code requires submission of Black folk to the dominant race and in police encounters today, it says that your life can end in a millisecond. Amy Cooper of Central Park relied upon the code when she called the police and falsely accused a black man of threatening her. What made her disregard the fact that she was being filmed? Yes, R causes blindness too. Amy relied upon and expected the police to enforce the code of the well-behaved Negro. While poor Amy read law enforcement right, as she has faced no legal ramifications for her act, she underestimated the social tolerance for her demand and so her name will forever be used as an example of a woman who expected privilege and used racism to achieve her goal.

What this Intolerance means.

With the demonstrations of protest all around us, the message is clear: We will not be your well-behaved Negro. Whether its law enforcement or the Board room, the time for sucking it up and watching the effects of R, even if it is quietly implemented to achieve a desired goal those times are over. I have felt this indignation in me. I have seen it in my friends, whether black, white, Hispanic or other races or creeds. The folks we see in the streets are not just the recipients of these heinous acts but those who have grown intolerant of them as well.

This intolerance also means that we must take affirmative steps to eradicate the effects of R in every level of our lives.

What we must Understand

That racism and the remnants of it have survived for more than 400 years in this country, because too many have been silent.

We must recognize that these R practices whether overt, subtle or existing in the form of whispers disparaging the work of another who isnt even aware of the conversation exist and thrive in the dark of private conversations where they are less likely to be detected or judged by a collective body.

Racism is always about power. Those who use its tools have an objective that allows that person to have the upper hand.

Racism always leaves someone or some group of people on the outside of the conversation where future control is being determined.

One of the most difficult forms of R is often found in the political arena, pitting one person against the other, isolating people of the same race from one another. This may appear between political parties or within the same (think Trump and his Black spokespersons).

What we must Do

Recognize that an intolerance of racist and oppressive tactics is a bullying tactic. Being silent is a complicit act that harms another human being.

Know that this growing intolerance for racism includes an intolerance for the fake, presumed, self-proclaimed wokeness that is in actuality, a form of sleep walking.

Presume that we do not understand and work to gain understanding.

Recognize that a failure to act now is a continuing injury to the recipients of both overt and subtle acts that oppress a people that deserve respect and a recognition of their value.

Ask questions at the library not of your black friends. While some black folk, myself included, do not mind discussing this issue, it is not my responsibility to educate those who may need further enlightenment.

Speak up when those private conversations take place that devalue a person of color and dig to get at the source of reason for the discussion. Ask the question, what does the person who whispers have to gain from that conversation?

Speak up when the telling of history does not recognize the value of all involved.

Talk to your friends and work to learn together.

Remember that the burden of racism and what it has created belongs to all and we must all work to eradicate it.

Understand that R has impacted every area of American life, from the church, to the schools, to the courts, to the board room.

Dont give up. Just because this is the way it has been, that fact doesnt determine our future.

Conclusion

I want my friends to know that I appreciate the words of assurance. I know that we have many allies who want to do the right thing. But the desire to do the right thing isnt enough. We must collectively meet wherever we are and ask, what can I do? How can I learn and how can I assist in implementation of better procedures and policies? How can I listen better today? How can we weed out code words in conversation and make sure that we are never complicit in the divisions that racism creates. This is our burden, this is our work. Lets tear these barriers down, together!

Read more from the original source:
Opinion: Commentary: Moving Forward: The Anatomy of Racism in our Everyday Lives - Virginia Connection Newspapers

Attack on Titan Anatomy: 5 Weird Things About Eren Yeager’s Titan – CBR – Comic Book Resources

As the combination of two powerful Titans, the anatomy of Attack on Titans lead protagonist Eren Yeager is the weirdest in the series.

The nature of the Titans that walk the forsaken lands beyond Wall Maria is one of thebiggest questions of Attack on Titan. While all Titans are gargantuan human-like creatures, there exist massive variations in their anatomy and unique abilities. Pure Titans are mindless, deformed giants whose deadliness varies depending on traits such as their height and nocturnal adaptations, while intelligent Titans are those controlled by humans and designed to have unique combat specializations of their own. The Titan ErenYeagercontrols, naturally, falls into the latter category.

But even among the ranks of humans with Titan powers, Erens situation is nothing close to simple. As someone who was never intended to wield a Titan -- or at least not according to the schemes of his king or the enemy beyond the walls -- his Titan anatomy has both great limitations and great potential.

Related:Attack on Titan's Criticism of Fascism & Racism Is Far From Subtle

Here's a breakdown of the five most unique details about the anatomy of Eren Yeagers Titan:

This first detail neatly sums up why Erens Titan is so different from the rest: Eren technically has access to two Titans instead of just one. Thanks to the efforts of his father,Grisha Yeager,Eren has full access to the powers of the Attack Titan and limited access to the Founding Titan. This was brought about by his father as the Attack Titan eating Frieda Reiss as the Founding Titan, and then Eren as a pure Titan eating his own father. Titan powers are inherited by eating someone who already has access to those powers, and because of the Eren-Grisha-Frieda chain of consumption, Erens Titan anatomy mostly resembles that of the typical Attack Titan, but has notable exceptions.

RELATED:Tokyo Ghoul: Are Full Kakuja Ghouls Actually Titan Shifters?

Nine Titans can be controlled by humans in Attack on Titans world, and throughout the series each one is characterized by the combat specializations unique to that Titan. For example, the Armored Titan has plated segments protecting its body that render it invulnerable to swords and cannons, and the Colossus Titan stands at a 60 meter height that dwarfs the other human-controlled Titans. Each of the nine Titans is defined and distinguished by these signature characteristics.

However, Erens Attack Titan is a strange exception to the rule. The Attack Titan has all the characteristics that are universal to Titans -- with the most important being super regeneration -- but it lacks any unique abilities of its own. When every other human-controlled Titan has its own weird abilities, the lack of a weird ability suddenly becomes weird.

RELATED:Attack on Titan Fans Feared the Worst With a Studio Change But Got the Best

The traits of Erens Titan are weird, in large part because they seem contradictory at first glance. Although the Attack Titan lacks any unique abilities at its base, thischanged in Season 3 of the animedue to a special serum possessed by the Reiss family. The serum upgraded the Attack Titan, allowing Eren to harden its skin into a crystalline substance that is invaluable for both defense and delivering devastating punches.

Its still not an ability unique to the Attack Titan, since in Season 1 the Female Titan naturally possessed it, but its arguably the most vital Titan power Eren wields. All Titans carcasses are known to disintegrate once theyre slain or the human controllers are cut free from the body, but in hardened form the crystalline carcass can remain. Its this anatomical trait that allows Survey Corps to patch up the walls using hardened skin from the Attack Titan.

RELATED: From Attack On Titan To Parasyte: Animes GROSSEST Hero Transformations

Eren may have inherited the Founding Titan, but even though he theoretically has access to this Titans abilities, he cant fullyuse them. The Founding Titan was meant to be passed down through the Reiss familys royal bloodline. Because Eren lacks royal blood, under normal circumstances he cannot access the Founding Titans incredible abilities -- namely, human memory manipulation and total command over the wandering hordes of pure Titans.

Yet these abilities are not utterly lost to Eren. If he comes into physical contact with a Titan from a royal bloodline, hes able to temporarily command Titan hordes and delve into the memories stored within the Founding Titan.

RELATED: Attack On Titan Just Featured A Long-Awaited Titan Team-Up

The final trait on this list is possibly one shared by every human-controlled Titan, but so far weve only seen Eren contend with it in the series. Its also one of the lesser-explored details of Titan anatomy. If Eren lacks a strong force of will, its possible for him to fall into a trance-like state and lose control of the Attack Titan. He nearly killed his adopted sister Mikasa in a state of feral rage when this occurred, but since that day we havent seen him struggle to control his Titan again. This raises an interesting question -- does the Attack Titan have a mind of its own when Eren isnt in control?

Whatever the case may be, theres no doubt that Eren Yeagers Titan anatomy is quite strange, and Attack on Titan approaches its final season, its only likely to get stranger.

Attack on Titan Season 4 is scheduled to premiere this Fall.

KEEP READING: Why You Should Be Excited For Attack on Titan Season 4

My Hero Academia: 10 Hero Quirk Combinations That Would Be Unstoppable

Alex Lukas is a freelance writer and rookie novelist. He graduated as a double major in Film Production and International Relations from Occidental College in Los Angeles, and is well-versed in media analysis from both an entertainment and political perspective. In his spare time he tames leopard geckos.

Go here to read the rest:
Attack on Titan Anatomy: 5 Weird Things About Eren Yeager's Titan - CBR - Comic Book Resources

Anatomage Announces Its Upcoming eBook For Students To Experience and Interact with True-Human Cadavers Online – BioSpace

SAN JOSE, Calif., July 2, 2020 /PRNewswire/ -- AnatomageInc, a market leader in 3D medical imaging technology, today announces Anatomage eBook - an eBook that enables students to study anatomy and physiology through interacting with the anatomy of true-human cadavers online.

Anatomage eBook consists of 25 chapters that feature major anatomy and physiology concepts of 12 major body systems and functions. For each concept, users are visually guided through all of the related body parts - from macro to microstructures - with educational texts and dynamic images. As the majority of images from Anatomage eBook stem from the Anatomage Table's true-human cadavers, the digital contents exhibit accurate human anatomy content that helps students decipher and memorize anatomical terms easier.

Anatomage eBook is optimized for online learning which allows students to access the contents from anywhere. Unlike other online tools, the eBook offers a unique user experience that is highly engaging and easy to navigate. The contents are highly visual and based on Anatomage's renowned photorealistic human data.

Modeled as a dynamic web-based textbook, Anatomage eBook produces an interactive, aesthetically pleasing interface where students can explore a variety of anatomy and physiology topics using interactive controls. From tapping on the screen to scrolling the mouse, users are able to navigate through diverse anatomical parts. Adjacent and tiny structures are also highlighted with colors for distinguishment. Furthermore, cadaveric models can be rotated and engaged for a better view. Given its high interactivity, Anatomage eBook efficiently transforms the clinical and anatomical terminology into illustrative learning visuals that enhance students' memory.

Anatomage eBook is an effective learning tool for undergraduate Anatomy & Physiology students. To assist with assessing student learning, questions are included for various key topics in the textbook. Since Anatomage eBook can be accessed anywhere with Internet connectivity, it can be used as an online learning tool for both in-class and self-study sessions. By offering a multimedia platform combined with its accurate anatomy and physiology representation, Anatomage eBook embodies a new standard for digital textbooks in the medical education industry.

Adopting the Anatomage eBook will enable your students to -

For more information, please visit here or contact info@anatomage.com.

About AnatomageAs a market leader in medical virtualization technology, Anatomage enables an ecosystem of 3D anatomy hardware and software, allowing users to visualize anatomy at the highest level of accuracy. Established in both education and healthcare industries, Anatomage is transforming standard anatomy learning, medical diagnosis and treatment planning through its highly innovative products.Contact:Jack ChoiCEOAnatomage Inc.Phone: 1-408-885-1474Email: info@anatomage.comwww.anatomage.com

View original content to download multimedia:http://www.prnewswire.com/news-releases/anatomage-announces-its-upcoming-ebook-for-students-to-experience-and-interact-with-true-human-cadavers-online-301087288.html

SOURCE Anatomage

Go here to read the rest:
Anatomage Announces Its Upcoming eBook For Students To Experience and Interact with True-Human Cadavers Online - BioSpace