A statistical model can accurately predict the risk of bloodstream infections in a subset of children with cancer, according to a study published in the Journal of Clinical Oncology.
For children with cancer, fever is a common complication. While guidelines exist for managing fever in children with cancer who have very low white blood cell counts, no such guidelines exist for children with cancer without severely low levels.
Because of this, identifying patients with cancer and fever who are at a higher risk for bloodstream infections can be difficult, said Jenna Rossoff, MD, assistant professor of Pediatrics in the Division of Hematology, Oncology and Stem Cell Transplantation and a co-author of the study.
While some hospitals may choose to pre-emptively administer antibiotics to a feverish child being treated for cancer, that can lead to other complications such as antibiotic resistance later on, Rossoff said.
In the study, Rossoff and her collaborators sought to test a model developed to predict the risk of bloodstream infections, which can develop into sepsis, in feverish children with cancer.
This model has been designed to delineate bloodstream infection risk in these patients at presentation based on a variety of variables, and the overall goal is to reduce unnecessary antibiotic use and also identify patients obviously at high risk for a bloodstream infection, said Rossoff, who is also a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
To test the model, investigators collected data on fever episodes occurring in pediatric cancer patients from 18 academic medical centers. They then compared the models predictions to the seven-day clinical outcomes in each of the 2,500+ cases and found that the model could accurately predict which patients were more likely to experience bloodstream infections, according to the study.
The findings suggest the model accurately identifies high-risk patients and could reduce unnecessary antibiotic use, Rossoff said.
Importantly, the paper showed that in the patients whose predicted risk for bloodstream infections using this model was low, there was a very low rate of true bloodstream infections, Rossoff said. For those few percent of patients who did have a bloodstream infection, there were no severe outcomes.
Moving forward, Rossoff said she would like to see more studies done testing the model in children with cancer who have undergone stem cell transplants and other novel therapies.
Fevers are a pretty frequent complication during treatment and when our kids dont need antibiotics, we should be avoiding them to prevent antibiotic resistance and disruption of the gut microbiome, she said. As much as we can safely safely being the key word decrease antibiotic administration, that would be a great thing overall.
The study was supported by the National Center for Research Resources Grant KL2TR000446.
Here is the original post:
Predicting Infection Risk in Childhood Cancer - News Center - Feinberg News Center
- Modest Changes in Kids' Developmental Scores Seen From Pandemic - Medpage Today - April 23rd, 2024 [April 23rd, 2024]
- This pediatrics subspecialty has the best work-life balance - MD Linx - April 23rd, 2024 [April 23rd, 2024]
- PM Pediatrics Cobble Hill closing Pediatric urgent care options in Brooklyn and lower Manhattan - Brooklyn Bridge Parents - April 23rd, 2024 [April 23rd, 2024]
- Bethesda Pediatrics awarded $18,000 grant by GIVE - Yahoo! Voices - April 23rd, 2024 [April 23rd, 2024]
- Nemours Children's Health, UCF Partner to Elevate the Quality of Healthcare for Florida's Children - UCF - April 23rd, 2024 [April 23rd, 2024]
- Pediatricians told to talk to patients and parents about climate. - Grist - April 23rd, 2024 [April 23rd, 2024]
- Getting a good night's rest is vital for neurodiverse children pediatric sleep experts explain why - The Conversation - April 23rd, 2024 [April 23rd, 2024]
- Tina Cheng Honored as Exceptional CMO - Research Horizons - Research Horizons - April 23rd, 2024 [April 23rd, 2024]
- Let's talk about childhood injury prevention | Hub - The Hub at Johns Hopkins - April 23rd, 2024 [April 23rd, 2024]
- More young people with depression, anxiety in Virginia | Headlines - InsideNoVa - April 23rd, 2024 [April 23rd, 2024]
- Pediatrics fundraising event at Altru helps children with critical needs - Grand Forks Herald - April 15th, 2024 [April 15th, 2024]
- Public perceptions of families affected by pediatric cancer and educational work in pediatric oncology | Pediatric ... - Nature.com - April 15th, 2024 [April 15th, 2024]
- The pediatrician, the resident, the strawberry monster, and the zebra - VUMC News - VUMC Reporter - April 15th, 2024 [April 15th, 2024]
- Receptor targeting to identify medications for pediatric mental health concerns - Contemporary Pediatrics - April 15th, 2024 [April 15th, 2024]
- Hypoglossal nerve stimulation offers hope for pediatric Down syndrome patients with OSA - News-Medical.Net - April 15th, 2024 [April 15th, 2024]
- Efforts to reduce wait times for developmental evaluations - Baylor College of Medicine | BCM - April 15th, 2024 [April 15th, 2024]
- Nasal oxidative stress mediating the effects of colder temperature exposure on pediatric asthma symptoms | Pediatric ... - Nature.com - April 15th, 2024 [April 15th, 2024]
- Week in review: A new dermatology case study, and a new treatment for severe asthma - Contemporary Pediatrics - April 15th, 2024 [April 15th, 2024]
- Chordae Tendinea Rupture and Pulmonary Valve Vegetation in Pediatric Endocarditis: A Rare Condition - Cureus - April 7th, 2024 [April 7th, 2024]
- Pruitt named director of academic pediatrics division Washington University School of Medicine in St. Louis - Washington University School of... - April 7th, 2024 [April 7th, 2024]
- Researchers Show Injury Prevention Program Reduces Injuries in Young Children | Newsroom - UNC Health and UNC School of Medicine - April 7th, 2024 [April 7th, 2024]
- Provident Healthcare Partners Advises SouthernMED Pediatrics and Sweetgrass Pediatrics in a Partnership with U.S. ... - PR Newswire - April 7th, 2024 [April 7th, 2024]
- Online child safety laws could help or hurt 2 pediatricians explain what's likely to work and what isn't - The Conversation - April 7th, 2024 [April 7th, 2024]
- Hundreds of blue pinwheels draw attention for the need of doctors who specialize in child abuse pediatrics - MyStateline.com - April 7th, 2024 [April 7th, 2024]
- Pediatricians can help teens quit vaping and using tobacco - Odessa American - April 7th, 2024 [April 7th, 2024]
- CUTTING-EDGE RESEARCH SHAPING CHILDREN'S HEALTH SHOWCASED AT THE PEDIATRIC ACADEMIC ... - PR Newswire - April 7th, 2024 [April 7th, 2024]
- New NIAID report on maternal COVID-19 vaccination offers direct evidence of protection for newborns - Contemporary Pediatrics - April 7th, 2024 [April 7th, 2024]
- Navigating Pediatric Diabetes: A Q&A With Leading Expert David Maahs, MD - Stanford Medicine Children's Health Blog - Stanford Children's Health - March 29th, 2024 [March 29th, 2024]
- Linaclotide Succeeds for Functional Constipation in Children | GI and Hepatology News - MDedge - March 29th, 2024 [March 29th, 2024]
- Testing and diagnoses capacity of 2009 influenza and COVID-19 pandemics - Contemporary Pediatrics - March 29th, 2024 [March 29th, 2024]
- Healing the divide: Advancing access to pediatric care - HealthLeaders Media - March 29th, 2024 [March 29th, 2024]
- McMaster Child Health Research Day charts the future of pediatric health - Brighter World - March 29th, 2024 [March 29th, 2024]
- This is serious: The results of a measles outbreak have harmful outcomes - Contemporary Pediatrics - March 29th, 2024 [March 29th, 2024]
- Unlocking the Power of Influenza Vaccines for Pediatric Population: A Narrative Review - Cureus - February 29th, 2024 [February 29th, 2024]
- Human Papillomavirus Vaccines - Immunizations - American Academy of Pediatrics - February 29th, 2024 [February 29th, 2024]
- The role of the pediatrician in school-based mental health services - Contemporary Pediatrics - February 29th, 2024 [February 29th, 2024]
- Reminder for IPRC Webinar Preventing Secondary Trauma and Practical Self Care for Pediatric Rehabilitation ... - RCPA - February 29th, 2024 [February 29th, 2024]
- PCORI Awards CYSHCNet Researchers $5.5 Million to Study Transitions for Children and Caregivers from Hospital-to ... - UNC Health and UNC School of... - February 29th, 2024 [February 29th, 2024]
- Viewpoint: Journal Pediatrics reneges on its commitment to print response to botched article claiming GMOs are ... - Genetic Literacy Project - February 29th, 2024 [February 29th, 2024]
- NYC medical school will go tuition-free thanks to $1 billion gift from former pediatrics professor - Anchorage Daily News - February 29th, 2024 [February 29th, 2024]
- Innovative New Pediatric Facility Helps Alleviate Patient Anxiety - Healthcare Construction and Operations News - February 29th, 2024 [February 29th, 2024]
- Most pediatricians aren't prepared to handle teen opioid use, study says - WCVB Boston - February 29th, 2024 [February 29th, 2024]
- As Medicaid Shrinks, Clinics for the Poor Are Trying to Survive - The New York Times - February 29th, 2024 [February 29th, 2024]
- Many children hospitalized with COVID continue to face challenges. - Baltimore Sun - February 29th, 2024 [February 29th, 2024]
- Exposure to neighborhood violence linked to unmet health needs and increased care utilization in children - News-Medical.Net - February 29th, 2024 [February 29th, 2024]
- OUtMATCH: Omalizumab Proves Utility in Multiple Food Allergies for Pediatric, Adult Patients - MD Magazine - February 29th, 2024 [February 29th, 2024]
- Neffy pharmacokinetic profiles compared to epinephrine injections - Contemporary Pediatrics - February 29th, 2024 [February 29th, 2024]
- Clinician quiz: AAP clinical practice guideline for treatment of children with obesity - Contemporary Pediatrics - February 29th, 2024 [February 29th, 2024]
- Contributed: Shortcomings and opportunities for health equity in pediatrics - Mobihealth News - January 27th, 2024 [January 27th, 2024]
- Committed to physician education to enhance children's health - UChicago Medicine - January 27th, 2024 [January 27th, 2024]
- What's leading to youth sports burnout? American Academy of Pediatrics report says 70% of kids are dropping out by 13 - WLS-TV - January 27th, 2024 [January 27th, 2024]
- Washington University School of Medicine joins collaboration to improve pediatric heart disease care - News-Medical.Net - January 27th, 2024 [January 27th, 2024]
- How to Treat Coughs in Kids - Health Matters - January 27th, 2024 [January 27th, 2024]
- COVID-19 vaccination during pregnancy and offspring neurodevelopment - Contemporary Pediatrics - January 27th, 2024 [January 27th, 2024]
- Discontinuing contact precautions for pediatric patients with methicillin-resistant Staphylococcus aureus - Contemporary Pediatrics - January 27th, 2024 [January 27th, 2024]
- Viewpoint: American Academy of Pediatrics fiasco International Association for the Research on Cancer is the ... - Genetic Literacy Project - January 27th, 2024 [January 27th, 2024]
- Recent reports of measles in multiple states - Contemporary Pediatrics - January 27th, 2024 [January 27th, 2024]
- Expert shares advice for parents navigating pediatric influenza, COVID-19, and RSV this winter - Newswise - January 27th, 2024 [January 27th, 2024]
- Global Group of Researchers Release New Criteria for Diagnosing Pediatric Sepsis and Septic Shock - AboutLawsuits.com - January 27th, 2024 [January 27th, 2024]
- Recurrent Syncope Unveiling Pulmonary Hypertension Secondary to Pulmonary Artery Thrombi in a Pediatric Patient - Cureus - January 8th, 2024 [January 8th, 2024]
- ChatGPT bombs test on diagnosing kids' medical cases with 83% error rate - Ars Technica - January 8th, 2024 [January 8th, 2024]
- ChatGPT is terrible at diagnosing child medical cases, according to new study - Mashable - January 8th, 2024 [January 8th, 2024]
- The clinical takeaways of the RSV immunizations - Contemporary Pediatrics - January 8th, 2024 [January 8th, 2024]
- Missouri pediatricians provide eight parenting goals to start the new year strong - Kirksville Daily Express and Daily News - January 8th, 2024 [January 8th, 2024]
- Reviewing the 2023 RSV season and an outlook on 2024 - Contemporary Pediatrics - January 8th, 2024 [January 8th, 2024]
- Predictive Factors for Insulin Resistance in Pediatric Obesity: A Comprehensive Analysis - Physician's Weekly - December 31st, 2023 [December 31st, 2023]
- Locals partner to open pediatric clinic in Brookhaven - Daily Leader - Dailyleader - December 31st, 2023 [December 31st, 2023]
- Infants Pay the Price When Parents Battle Food Insecurity and Benefits Red Tape - Research Horizons - Research Horizons - December 31st, 2023 [December 31st, 2023]
- RSV Roundtable: Addressing the senior population - Contemporary Pediatrics - December 31st, 2023 [December 31st, 2023]
- Rehabilitation Following Above-Knee Amputation in a Pediatric Osteosarcoma Patient: A Case Report - Cureus - December 22nd, 2023 [December 22nd, 2023]
- Campbell chair of Pediatrics talks with WRAL about flu, respiratory illness - News | Campbell University - Campbell University News - December 22nd, 2023 [December 22nd, 2023]
- Democrats eye appropriations to protect pediatrician training - Roll Call - December 22nd, 2023 [December 22nd, 2023]
- Discussing epilepsy's initial signs and treatments in the pediatric population - Contemporary Pediatrics - December 22nd, 2023 [December 22nd, 2023]
- Georgia children's hospitals get pediatrics workforce grant, over $700K in total funding WABE - WABE 90.1 FM - December 22nd, 2023 [December 22nd, 2023]
- Pediatric obesity during COVID-19: the role of neighborhood social vulnerability and collective efficacy | International ... - Nature.com - December 22nd, 2023 [December 22nd, 2023]
- Pediatric Drugs Market Size Expected to Reach USD 363.86 Billion by 2032 - GlobeNewswire - December 22nd, 2023 [December 22nd, 2023]
- Brief Training Improves Counseling by Pediatricians on Social Media Safety - Physician's Weekly - December 22nd, 2023 [December 22nd, 2023]
- Maternal Flu Shot Protects Infants Against Severe Disease - Medpage Today - December 22nd, 2023 [December 22nd, 2023]
- Missouri pediatricians provide holiday tips for families and children - Kirksville Daily Express and Daily News - December 22nd, 2023 [December 22nd, 2023]
- Amateur Spotlight: Retired Pediatrician Gives Back And Pushes Forward - The Chronicle of the Horse - December 22nd, 2023 [December 22nd, 2023]