Scientists Assemble Full Genomes for Domesticated Apple and Two of Its Wild Progenitors – Technology Networks

The fabled Silk Road - the 4,000-mile stretch between China and Western Europe where trade flourished from the second century B.C. to the 14th century A.D. - is responsible for one of our favorite and most valuable fruits: the domesticated apple (Malus domestica).

Snack-packing travelers would pick apples at one spot, eat them and toss their cores many miles away. The seeds grew into trees in their new locations, cross-bred with the wild species, and created more than 7,000 varieties of apples that exist today.

Hybridizations with wild species have made the apple genome very complex and difficult to study. A global team of multi-disciplinary researchers - co-led byZhangjun Fei,faculty member at Boyce Thompson Institute (BTI), andGan-Yuan Zhong, scientist with the USDA-Agricultural Research Service (ARS) in Geneva, New York - tackled this problem by applying cutting-edge sequencing technologies and bioinformatics algorithms to assemble complete sets of both chromosomes for the domesticated apple and its two main wild progenitors.

The researchers discovered that the apple's unique domestication history has led to untapped sources of genes that could be used for crop improvement, such as improving size, flavor, sweetness and texture.

"Plant breeders could use this detailed information to improve upon traits that matter most to consumers, which today is primarily flavor," says Fei, also an adjunct associate professor in Cornell University's School of Integrative Plant Science (SIPS).

"Perhaps more importantly," he added, "the information will help breeders produce apples that are more resistant to stress and disease."

The research is described in apaperpublished inNature Geneticson November 2, with authors from BTI, Cornell University, Cornell AgriTech, the U.S. Department of Agriculture (USDA) and Shandong Academy of Agricultural Sciences.

Follow-up discussions among Fei, Zhong and other colleagues at Cornell, inspired them to build better and new apple reference genomes by applying new sequencing and assembly technologies to material in USDA's Geneva Clonal Repository. The repository, which is housed atCornell AgriTech, holds the largest collection of apple accessions in the world. Many of these accessions can be traced back to the Silk Road.

In the current work, the researchers sequenced, assembled and compared the full reference genomes for three species: Gala, a top commercial cultivar of M. domestica; and apple's two main wild progenitors, the European crabapple (M. sylvestris) and the central Asian wild apple (M. sieversii), which together account for about 90% of the domesticated apple's genome.

The results provide apple breeders with detailed genomic roadmaps that could help them build a better apple.

"We wanted to develop new genomes, especially the wild progenitors, because of the tremendous impact they could have on understanding apple's genetic diversity and identifying useful traits for breeding new cultivars," said Zhong, who is also an adjunct associate professor in SIPS.

By comparing the three genomes, the researchers were able to identify which progenitor species contributed the genes responsible for many traits in the domesticated apple. For example, the team found that the gene giving apple its crunchy texture is located near the gene that makes it susceptible to blue mold.

"Now that we know exactly where those two genome regions are," Fei said, "breeders could figure out a way to keep the texture gene and breed out or edit out the blue mold gene to produce a more disease-resistant cultivar."

The team identified about 50,000 genes in the pan-genome of the domesticated apple, including about 2,000 that were not present in previously published reference genomes for apple species. "These 'missing genes' turn out to be really important, because many of them determine the traits of greatest interest to apple breeders," Fei said.

Using RNA extracted from different stages of Gala fruits, they also identified genes linked to texture, aroma and other fruit characteristics that were preferentially expressed between the two copies of the genes.

"That provides us and breeders with an even deeper understanding of the genetic diversity underlying a particular trait," Zhong said. "The findings will help our group better manage and curate more than 6,000 apple accessions in the USDA Geneva Clonal Repository," Zhong adds, "as well as enable us to provide critical genetic and genomic information associated with the accessions to breeders and other researchers."

Reference: Sun X, Jiao C, Schwaninger H, et al. Phased diploid genome assemblies and pan-genomes provide insights into the genetic history of apple domestication. Nature Genetics. 2020. doi:10.1038/s41588-020-00723-9.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Scientists Assemble Full Genomes for Domesticated Apple and Two of Its Wild Progenitors - Technology Networks

Benchmark : Genetics has signed a 5-year ova agreement with AquaCon – Marketscreener.com

3 November 2020

The contract between Benchmark Genetics and AquaCon involves deliveries of genetics to the land-based facilities that AquaCon are planning to build in Maryland, USA. Benchmark's Icelandic company, StofnFiskur, will supply approximately 40 million ova to AquaCon over five years. The agreement confirms and consolidates Benchmark's strong position as a genetics supplier to land-based farming worldwide.

Benchmark Genetics has been producing land-based broodstock and ova in Iceland since the early 1990s and has long-standing experience with land-based salmon farming worldwide. Geir Olav Melingen, Commercial Director at Benchmark Genetics, considers this a clear competitive advantage when selling to new land-based projects:

'As a leading supplier to land-based farming, we have gradually gained comprehensive experience in securing deliveries to destinations all over the world. Since we keep our broodstock on land and thereby have full control over the maturation and spawning, we are in the position to produce and deliver ova to customers every single week of the year. The term 'egg season' is outdated with us'.

Security of supply was an essential factor for why AquaCon chose the company as a supplier.

Pl Haldorsen is the CEO of AquaCon, which currently has a head office in Oslo and shortly plans to go public. 'We have chosen to secure genetics at an early stage, as we consider ova as a key strategic success factor of our ambitious growth plans', he says.

Haldorsen explains that Benchmark Genetics satisfies AquaCon's requirements for the security of supply, biosecurity and genetic traits adapted to land-based RAS farming:

'Our production plan presupposes regular deliveries of ova throughout the year, and Benchmark Genetics has a production model for land-based broodstock that makes us confident that we will receive deliveries following our plans'.

Located on the south-west shore of Iceland, StofnFiskur's land-based facilities have no other salmon farms nearby. The intake water, both freshwater and seawater, comes from boreholes and is entirely pathogen-free. StofnFiskur's four farms are approved according to the OIE compartment standard, meaning that the zones around each farm are defined as entirely isolated and protected from external disease threats. As an example, Benchmark Genetics is the only genetics company approved by Sernapesca for export of ova to Chile.

'The unique location and production model makes us confident that we can deliver eggs that have the highest biosafety standard to AquaCon,' says Geir Olav Melingen.

Geir Olav also proudly says that all energy used for broodstock and ova production in Iceland comes exclusively from renewable sources. Thus, the production has a relatively low CO2 footprint, even though land-based production is often considered energy-intensive.

Benchmark Genetics strongly believes that significant parts of the future growth in salmon farming will come from land-based production. Therefore, the company has developed production concepts and products that are adapted to the specific needs of this part of the industry.

'The genetic weighting of growth and quality traits forms the foundation of our product, SalmoRAS4 +. Besides, we have also developed methods in the production of broodstock that produce offspring that will not become sexually mature. This means that the operations like AquaCon can produce at higher temperatures to optimize growth', says Melingen.

'We, therefore, have great faith that land-based farming in the future will be competitive on production costs compared to traditional sea-farming', Geir Olav Melingen concludes.

Disclaimer

Benchmark Holdings plc published this content on 03 November 2020 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 03 November 2020 09:34:02 UTC

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Meet The First Black Woman To Earn a Ph.D. in Neuroscience from the University of Rochester – Because of Them We Can

She's a whole scholar!

Dr. Monique Mendes just made history as the first Black woman to earn a Ph.D. in neuroscience from the University of Rochester, Diverse Education reports.

Mendes is a native of Jamaica who had to make several adjustments to get used to the American culture and education system when moving to the United States. Nonetheless, she persisted, attending public schools and eventually pursuing her undergraduate education at the University of Florida, where she majored in biology. It was during that time, working in the lab, where she discovered her love for neuroscience.

"[The lab] is where I had real hands-on experiences working on a project from the beginning all the way to the end. I had to do all the experiments, and I helped with writing the paper. That was where I realized that it was really exciting to be a part of science," Mendes told Diverse Education.

While at the University of Florida, she joined the McNair Scholars Program, which supports undergrad students with mentorship, financial assistance, and other resources in preparation for a doctoral degree. After earning her bachelor's degree, she enrolled at the University of Rochester Medical Center's (URMC) Del Monte Institute for Neuroscience to pursue her doctorate. As a first-generation college student, she depended on mentorship from faculty members and credited them with her success.

"I definitely had no idea what was going on in the beginning. I was fortunate to have a number of mentors throughout my career that really put my success as a priority. Throughout the years, I gained the experience and the resources I needed to succeed," Mendes told reporters.

She excelled during her time in graduate school. Mendes received several accolades, including "being appointed as a fellow of the Neuroscience Scholars Program by the Society for Neuroscience. She [became] the first URMC graduate student to receive the F99/K00 NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience fellowship from the National Institute of Neurological Disorders in Stroke, and receiving the Edward Peck Curtis Award for Excellence in Teaching by a graduate student."

This past summer, Mendes defended her dissertation, "The Kinetics of Microglial Ontogeny and Maturation in the Adult Brain," a study about how cells renew and mature in the brain. Upon graduation, she was surprised to discover that she was the first Black woman in the history of URMC to receive a Ph.D. in neuroscience.

"I felt really incredibly empowered because I felt like I was setting the stage for more Black women to come to Rochester where they can feel like this is something they can do and something they can be successful at. Hopefully, I showed other women that this was possible," she told Diverse Education.

Mendes said that in hindsight, she didn't have one other person who looked like her in any of her classes during her time at the University. She found community elsewhere, finding other Black women in her field through social media campaigns like #BlackInNeuro. She hopes her journey can inspire other women to get into the field and says the burden is on schools and companies to create more opportunities for Black women in the sector.

"I would say create an environment that is not only diverse but inclusive and also paying attention to the cultures so that Black women can feel that this is a place for them. There is a seat at the table. I just think that's probably the most important thing," Mendes told reporters.

The neuroscientist is currently a postdoctoral fellow at Stanford University, where she plans to study how glia cells impact memory and learning. She hopes to transition to a faculty position in the future and become an advocate and mentor for other students.

When she's not working in the lab, she plays violin and plans to join a community orchestra. Mendes began playing violin at the Immaculate Conception High School in Jamaica. She has played at weddings and the Florida Youth Orchestra, the Brighton Symphony Orchestra, and the Rochester Philharmonic Orchestra here in the United States.

"It is a sense of community," Mendes told reporters. "It is nice to have something outside of science to relax. Surprisingly, orchestra is relaxing for me. People would think otherwise. But it feels good to have like a cohort of people that you can talk about something that you are all passionate about. I have had a lot of fun over the years."

Congratulations, Dr. Mendes!

Photo Courtesy of URMC Rochester

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Meet The First Black Woman To Earn a Ph.D. in Neuroscience from the University of Rochester - Because of Them We Can

Neuroscience Market 2020-2025 | Comprehensive Study COVID19 Impact Analysis | Global Key Players: GE Healthcare, Siemens Healthineers, Noldus…

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Neuroscience Market 2020-2025 | Comprehensive Study COVID19 Impact Analysis | Global Key Players: GE Healthcare, Siemens Healthineers, Noldus...

Neuroscience Antibodies and Assays Market Extensive Growth Opportunities to Be Witnessed by 2020-2028 – The Think Curiouser

The Neuroscience Antibodies and Assays Market report makes Accessible Today and Forthcoming financial and technical details of this business. Some of those chief insights of the business report comprise; different analysis of the market drivers & restraints, important market players engaged like business, detailed evaluation of their market segmentation & aggressive evaluation. It quotes CAGR values in proportions which help to be familiar with increase or fall happening in the marketplace for specific product for the particular prediction interval. International Neuroscience Antibodies and Assays Market report additionally encompasses tactical profiling of important players on the current market, systematic evaluation of the core competencies & brings a competitive landscape for the marketplace.

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The Neuroscience Antibodies and Assays Market report may be employed by both Conventional and new players from the market for whole knowhow of this marketplace. The business evaluation report brings into consideration important industry trends, market sizeand market share prices, and revenue quantity which help business to speculate that the approaches to boost return on investment (ROI). In addition, the industry record holds a considerable significance as its all about describing market definition, classifications, software and engagements. Together with the analysis of competition analysis conducted within this Neuroscience Antibodies and Assays Market report, the business can get fluency of these plans of important players on the marketplace which contains new product launches, expansions, arrangements, joint ventures, partnerships, and acquisitions.

Market Evaluation: Global Neuroscience Antibodies and Assays Market

Global Neuroscience Antibodies and Assays economy is set to see a Significant CAGR Of XX percent at the forecasted period of 2019-2026. This increase in the marketplace can be credited because of improvement in autoimmune identification and technology progress in the business.

The following players are covered in this report:

Thermo Fisher

Abcam

Bio-Rad

Merck

Cell Signaling Technology

Genscript

Rockland Immunochemicals

BioLegend

Santa Cruz Biotechnology

Roche

Siemens

Neuroscience Antibodies and Assays

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Breakdown Data by Type

Consumables

Instruments

Neuroscience Antibodies and Assays Breakdown Data by Application

Pharmaceutical & Biotechnology Companies

Academic & Research Institutes

Hospitals & Diagnostic Centers

Table of Contents : Neuroscience Antibodies and Assays Market

Part 01: Executive Summary

Part 02: Scope Of The Report

Part 03: Research Methodology

Part 04: Market Landscape

Part 05: Pipeline Analysis

Part 06: Market Sizing

Part 07: Five Forces Analysis

Part 08: Market Segmentation

Part 09: Customer Landscape

Part 10: Regional Landscape

Part 11: Decision Framework

Part 12: Drivers And Challenges

Part 13: Market Trends

Part 14: Vendor Landscape

Part 15: Vendor Analysis

Part 16: Appendix

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What Does the Future Hold for Neuroscience Antibodies and Assays Market? – Zenit News

Researchmoz has published a research report on the Neuroscience Antibodies and Assays market. The report covers comprehensive data on emerging trends, market drivers, growth opportunities, and restraints that can change the market dynamics of the report. It provides an in-depth analysis of the Neuroscience Antibodies and Assays market segments which include products, applications, and end-user applications.

This report also includes a complete analysis of industry players that cover their latest developments, product portfolio, pricing, mergers, acquisitions, and collaborations. Moreover, it provides crucial strategies that are helping them to expand their market share. The Global Neuroscience Antibodies and Assays Market research report is prepared by implying robust research methodology and including Porters Five Forces analysis to provide the complex matrix of the market.

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Key Highlights of the Report

The Neuroscience Antibodies and Assays market report covers the comprehensive analysis from the period of 2020-2026. It also provides the historic data of the market that has impacted positively or negatively to the market growth.

Regulatory policies and investment scenarios of the market are curated in a concise manner.

Top-winning market strategies and vital product offerings from the industry players.

A neutral perspective on the Neuroscience Antibodies and Assays market.

The broad analysis of the emerging trends in the market that helps to identify new market avenues and lucrative opportunities. Moreover, it aids in identifying product segments to maximize revenue and expand the market share.

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Market Segmentation Covered in the report.

segment by Type, the product can be split into2D Cell Models3D Cell ModelsCommercial 3D Cell ModelsInhouse 3D Cell Models

Market segment by Application, split intoDrug ScreeningToxicology3D Model DevelopmentBasic ResearchPhysiologic ResearchStem Cell ResearchRegenerative Medicine

Based on regional and country-level analysis, the Lungs in Vitro market has been segmented as follows:North AmericaUnited StatesCanadaEuropeGermanyFranceU.K.ItalyRussiaNordicRest of EuropeAsia-PacificChinaJapanSouth KoreaSoutheast AsiaIndiaAustraliaRest of Asia-PacificLatin AmericaMexicoBrazilMiddle East & AfricaTurkeySaudi ArabiaUAERest of Middle East & Africa

The market research report is classified into the types of products and is analyzed in a detailed manner. Moreover, it includes potential future products that are expected to open new market avenues and can change the dynamics of the market. Each product type is analyzed on the basis of their developments, growth, and threats in the different regions.

This report covers all the applications of the afore-mentioned products and also provides information on the potential applications in the foreseeable future. The dedicated research team has to look into all possible parameters and analyzed the applications that drive the growth of the market.

By Region

North America (U.S., Canada, Mexico)

Asia Pacific (India, China, Japan, South Korea, ASEAN, Rest of Asia Pacific)

Europe (Italy, Germany, France, Spain, Central & Eastern Europe, Rest of Europe)

Middle East & Africa (GCC, Turkey, Rest of the Middle East & Africa)

South America (Brazil, Argentina, Rest of South America)

One country of interest can be added with no additional cost on the report. Moreover, if more than one needs to be added, the regional segment quote may vary. In this report, the questions such as which country/region is expected to witness a steep rise in CAGR & year-on-year (Y-o-Y) are also covered.

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In the competitive analysis section of the report, leading as well as prominent players of the global Lungs in Vitro market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.The key players covered in this studyATCCLonzaEpithelixMattekEmulateMimetasTissuseInspheroCn Bio

Note: Additional companies can be profiled in the report.

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Yes. The market research report covers the detailed analysis of COVID-19 impact on the market. Our research team has been monitoring the market closely while it has been conducting interviews with the industry experts to get better insights on the present and future implications of the COVID-19 virus on the market.

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Yes, the market report can be further segmented on the basis of data availability and feasibility. We can provide a further breakdown in product types and applications (if applicable) by size, volume, or revenue. In the market segmentation part, the latest product developments and customer behavior insights are also included to give an in-depth analysis of the market.

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What Does the Future Hold for Neuroscience Antibodies and Assays Market? - Zenit News

International virtual technology in neuroscience conference to be held in Saudi Arabia – Arab News

JEDDAH: Saudi health chiefs on Monday warned members of the public to prepare for an increase in the number of coronavirus disease (COVID-19) cases in the Kingdom.With infection rates on the rise throughout the world, changing weather conditions, and people dropping their guard over safety precautions, Ministry of Health officials predicted an upsurge in cases was inevitable.Dr. Hani Joukhadar, the ministrys undersecretary for public health, said: Cases began to increase in most countries around the world, reaching unprecedented numbers in the US, England, France, Italy, and Spain.After numbers in these countries reached a stable status during the virus first wave, numbers in other countries began to increase, and this is expected to happen again.He added that a second wave of COVID-19 in many countries had come about following an easing of restrictions and people failing to adhere to precautionary measures.In Saudi Arabia, we expect an increase in cases as the weather is changing and more people are encouraged to go out and gather in homes. We also notice that people are less committed to wearing masks in public places, Joukhadar said.He hoped that awareness among Saudis and expats would help prevent a major second wave in the Kingdom but warned that the number of cases was still expected to increase.Saudi Arabia announced 381 new COVID-19 cases on Monday, meaning that 348,037 people in the country had so far contracted the disease. There were 7,928 active cases receiving medical care, of which 755 patients were in serious or critical condition.

FASTFACTS

Saudi Arabia announced 381 new COVID-19 cases on Monday.

436 more patients have recovered, raising the total number of recoveries in the Kingdom to 334,672.

In addition, 436 patients have recovered, raising the total number of recoveries in the Kingdom to 334,672. The death toll now stands at 5,437 after 17 more people were reported to have died.Saudi Arabia has so far conducted 8,151,353 polymerase chain reaction tests since the outbreak of COVID-19 in the country, and 53,819 were carried out in the last 24 hours.Meanwhile, the Saudi Red Crescent Authority organized 216 ambulance volunteer teams, consisting of 1,744 helpers, to work at the Prophets Mosque in Madinah to tackle medical cases in the past two weeks.Around 257 reports were initiated in the Prophets Mosque and its squares, 243 cases were handled, and 86 cases were transferred to the emergency teams stationed in the Prophets Mosque or nearby health centers.

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International virtual technology in neuroscience conference to be held in Saudi Arabia - Arab News

Here’s What Sugar Really Does to Your Brain, According to a Neuroscience Expert – msnNOW

Aleksandra Medvedeva - Getty Images A donut for breakfast, sweetened yogurt for lunch, a mid-afternoon syrupy latte here's how sugar affects your bain.

Sugar rush. Sugar high. Sugar buzz. Sugar slump.

Weve all heard these phrases that describe what our brains feel like when weve had too much of a sweet treat. But heres the thing about sugar and your brain: Your noggin needs it because sugar is its main fuel. Our brains run on glucoseit fuels our cells, including our brain cells. Were evolutionarily programmed to like sweets since theyre a great energy source. And when glucose levels are low in the blood (say, if you have hypoglycemia, or sometimes if it's just been a while since youve had something to eat), brain fog sets in, you fumble for words, you forget where you put down your phone, you look for a place to curl up for a quick nap.

When theres too much sugar in the system, however, that can set off some really bad stuff in your body and your brain.

When sugar hits our tongue, it activates certain taste buds that send a signal up to the brain, including the cerebral cortex, says Nicole Avena, Ph.D., assistant professor of neuroscience at Mount Sinai School of Medicine, who wrote a book about sugar addiction. The signal activates the brains reward system; dopamine (a feel-good brain chemical) is released and the behavior is reinforced, which makes us want to repeat it (mmmm, thats nice, give me more!).

Sugar is rare among dopamine-producing foods, Avena points out. Most of the time when we eat something new and tasty, dopamine is released the first time we taste it, she explains. This is an evolutionary advantage to help us to pay attention to new and different tastes, in case they make us sick. If we eat something new and dont get sick, typically the dopamine response then goes away the next timeso basically we only release dopamine in response to eating new foods. However, sugar is different. Its more like what happens with a drug of abuse, where dopamine is released every single time its consumed. Eating lots of sugar will continue to feel rewarding because the dopamine level doesnt balance out, which it does when eating healthier foods. So sugar does act a bit like a drug in our systemwhich is why people get hooked on sugary foods.

Gallery: 8 Healthy Eating Habits for Men (Eat This, Not That!)

We used to have to forage for sweet foodsbut no more, of course. Our world is filled with sugary foodsand not just the obvious donuts and super-sweetened, super-large latte drinks. A host of surprising foodsfrom ketchup to salad dressing to marinara sauce have sugar added to them. But our brains still function like sugar is a rarity.

When you repeatedly activate that reward system, your brain adapts and actually rewires itself, and you crave more and more. And research on rats turned up this finding: When they were fed high-sugar diets, the rats brains released less of a certain chemical that helps bodies put on the brakes, so they were less able to stop eating it.

Those sugar-saturated rats also werent as good at certain memory tasks, which showed that certain brain functions in the prefrontal area and hippocampus (an important area for memory formation and retention) were impaired. Other rat studies showed that a high sugar diet increased inflammation in this area, which also affected short term memory.

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You may not be aware that theres a strong connection between our gut and our brainand sugar comes into play here as well. When that sugary thing youve eaten hits your gut, Avena says, it activates sugar receptors there too, which signal the brain to release insulin to deal with the extra sugar youve eaten. To explain further: Excess sugar drives the pancreas to produce extra insulin, a hormone involved in blood sugar regulation. The insulin signals fat cells to store excessive amounts of glucose, fatty acids, and other calorie-rich substances. As a result, too few calories remain in the bloodstream, so the brain thinks its now low on fuel (since it has those very high energy needs). So your hunger level rises quickly. And sugar is appealing then because it provides quick energy. Thus, the cycle begins again. And thus, cravings for more and more brownies or ice cream or candy.

Want to get your brain in line with a healthier sugar level? Your brain can readapt when you cut back on sugar, and you wont crave it as much, says Avena. However, it can take awhile, even months, for this to happen, depending on the severity of dependence on sugar that one has.

To find out more about how to start cutting back on sugar and shake off a sugar dependence, try a 7-day detox plan. When you can successfully cut back, there's a payoff, besides a much healthier body: Just a small taste of, say, that delicious chocolate brownie will be enough of a sweet treat to satisfy you.

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Why our obsession with happy endings can lead to bad decisions – The Conversation UK

Alls well that ends well, wrote William Shakespeare over 400 years ago. The words may still seem to ring true today, but turns out they dont. We have just busted the old myth in a recent brain imaging experiment, published in the Journal of Neuroscience.

Experiences that end well are not necessarily good overall and experiences that end less well are not necessarily all that bad. For example, if you play five rounds of poker you get more overall enjoyment from winning twice in the middle than once at the end but we dont always realise this. In fact, one of the numerous foibles that prompt us to make poor decisions is an unwarranted preference for happy endings.

A happy ending means things got better as the experience unfolded. However focusing on happy endings can make us neglect what happened along the way. A happy ending may be brief and come after a long period of mediocrity.

Most of us enjoy it when our pleasant experiences are as long as possible, but at the same time we want things to end well. When Dumbledore died at the end of the Harry Potter film, some people might have felt that their whole experience was ruined. But enjoyment that has already been had should not be discounted because of a disappointing end. A long holiday with brilliant weather except for the last day is not worse overall than a much shorter holiday with good weather throughout.

However, this is exactly how some people feel about past experiences. And this obsession with things getting better and better all the time is a Bankers Fallacy focusing on short-term growth at the expense of long-term outcome. The core of the problem is a difference between what we enjoy while it lasts and what we want again after the final impression. Fixating on the happy end only maximises our final impression, not our overall enjoyment.

To examine this phenomenon, we invited 27 volunteers to take part in a virtual gambling experiment. The participants watched pots of money on a computer screen as gold coins of different sizes dropped into the pots one by one. A happy ending would be one where larger gold coins dropped at the end of the sequence.

The experiment took place in an MRI scanner, which allowed us to monitor the brains activity as the participants examined pairs of sequences of gold coins. After each pair they got to decide which pot they preferred.

It turned out that there is a good reason why people are attracted to happy endings. Computational analyses of the brain recordings showed that we register the value of an experience in two distinct brain regions. The overall value is encoded in a brain region called the amygdala, which has a mixed reputation. It has been argued that amygdala activation mediates emotional responses that can lead to irrational behaviour, but it has also been shown that it can rationally encode the outcome of economic saving strategies.

But the amygdalas influence on decision making is marked down by disincentive activity in a region called the anterior insula if a previous experience doesnt end well. The anterior insula is sometimes associated with processing negative experiences, such as disgust suggesting that some people are actively repulsed by the unhappy end.

In the gambling experiment, good decision makers picked the pots with the most money in total, regardless of whether they got larger gold coins at the end. They showed a strong representation of the overall value in the amygdala, whereas suboptimal decision makers had stronger activity in the anterior insula. In other words, good decision makers need to be able to overrule a displeasing impression of an experience, such as an unhappy end.

Lets say you are going out for dinner and you chose between a Greek and an Italian restaurant where youve been before essentially asking your brain to compute which meal was best last time. If all the dishes in the Greek restaurant were quite good then clearly the whole dinner was quite good. But if the Italian starter was so so, the main dish was only alright but the tiramisu at the end was amazing, then you might have formed an overly positive impression of that Italian restaurant because the meal had a happy ending.

Since these brain mechanisms operate whether we want it or not, they may be reinforced by human culture with its interest in manipulating our perceptions through advertising, propaganda, fake news and so forth exploiting our susceptibility to narrative and storytelling. No one is immune to advertising. The more institutions manipulate our thinking, the more our capacity to make good decisions is threatened.

Our intuitive brain really needs intervention from our more deliberate thinking processes to help us resist fake news and other manipulation. Most of us already know how to do this for example by writing a list of pros and cons to support ourselves into wiser decisions, rather than relying on our gut feeling.

So its not only Shakespeare who was wrong. If our daily behaviour becomes too narrowly focused on the immediate past, were missing out. We need to stop and think about what we are doing using our prefrontal cortex and overrule these impulses and focus on the most relevant aspect of the decision.

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Why our obsession with happy endings can lead to bad decisions - The Conversation UK

Hyperloop Health – Dominion Post – The Dominion Post

WVU researchers making sure future hyperloop travel is safe for its riders

WVU Today

Before the first Virgin Hyperloop ride takes off, the brains behind pioneering neuroscience research at West Virginia University will help ensure the health and well-being of its passengers and operators.

After all, theyll be traveling in pods through a vacuum tube at speeds breaking 600 mph.

It sounds like science fiction. But it will be a reality grounded in science, as engineers develop and tweak the mover system that will disrupt modern transportation as we know it.

Tried-and-tested science wont end there. Virgin Hyperloop plans to collaborate with the Rockefeller Neuroscience Institute at WVU to study how traveling at excessive speeds may impact the brain and body.

The RNI, led by Dr. Ali Rezai, has heralded numerous breakthroughs in recent years, ranging from first-of-its-kind procedures treating Alzheimers disease patients with focused ultrasound and those recovering from substance abuse through deep brain stimulation to predicting viral infections symptoms such as those associated with COVID-19 three days in advance through the use of wearable technology, a mobile app and artificial intelligence.

RNI researchers have already established the framework and tools that Virgin Hyperloop can apply at its certification center, which will span nearly 800 acres in Tucker and Grant counties.

Construction of the Hyperloop Certification Center will begin in 2021 with a planned Welcome Center, Certification Track and Operations Center, Pod Final Assembly Facility, Production Development Test Center and Operations, Maintenance and Safety Training Center.

Thats where the tinkering until perfection takes place before the system goes prime time. The plan is for Hyperloop to connect cities such as Pittsburgh and Chicago in 41 minutes, or New York City to Washington, D.C. in just 30 minutes.

Imagine zooming along at those 600 mph speeds in a tube with no windows. Or, better yet, operating the system itself.

These are super-high fast trains, said Rezai, executive chair, vice president of neuroscience and associate dean of RNI. Fundamentally, the RNI can collaborate with Virgin Hyperloop with a focus on safety, functionality and performance, for example, the neuroscience of workload, stress, cognitive ability and all other functions that can be quantified and measured, with respect to system users like passengers and operators.

Human functions may be impacted by high speed and the perception of knowing how fast you are moving. Without windows and a frame of reference, a persons balance, sensor, motor and other nervous systems function may be impacted as well. Well be looking at all of these factors in an integrated framework that measures physiological function and performance of the team and system operators and the passenger.

When the NBA restarted its 2019-20 season at Walt Disney World Resort over the summer, players had the option to wear a wedding band-like smart ring that could detect early COVID-19 symptoms. Months earlier, at the onset of the coronavirus pandemic, the RNI teamed up with the ring maker, Oura Health, to develop a digital health platform to predict viral illness symptoms such as with COVID-19.

More than 600 healthcare professionals and first responders participated in the first phase of the RNI study. The rings worked. They monitored physiological data including temperature, breathing and heart patterns, and when coupled with the RNI mobile app and its Digital Health platform, effectively predicted viral illness symptoms such as those associated with coronavirus for up to three days before appearing, with over 80 percent accuracy.

The RNI has all kinds of wearable gadgets, from wristwatches to even clothing, that constantly monitor a persons vitals and collect health data. By applying artificial intelligence and machine-learning to the data collected, the RNI team has predicted health outcomes and behaviors, such as cravings of patients recovering from substance abuse. In fact, before the COVID-19 pandemic, a large chunk of wearable technologies deployed by the RNI were geared toward patients overcoming opioid addiction and chronic pain.

Now the RNI may help to test these smart technologies for the Virgin Hyperloop project.

We are going to use wearable technologies to quantify the physiology of humans, Rezai said. From eye trackers to body sensors to electrocardiograms and electroencephalograms, we can measure, quantify and make sense of whats happening to the human body at 600 mph.

We will apply technologies that we have validated as state-of-the-art to measure physiological, cognitive, social, subjective and performance indicators, said Dr. Scott Galster, director of applied research at RNI.

Galster came to WVU in 2017 to head up human performance research at RNI after an extensive background with the Air Force Research Laboratory and working with NCAA and professional sports teams. He is the mind behind the muscle.

At the RNI, he and his team have continued work with military personnel and athletes, including WVU sports teams, to study fatigue, resilience and recovery.

Similarly, Virgin Hyperloop operators are like athletes and soldiers. Theyll have a specific quest and must train to be fit, mentally and physically, to achieve that target.

We want to optimize operator performance by creating competency-based training systems, applying our knowledge of interactions with complex automated systems examining factors such as decision-making, mental models and trust, Galster said.

RNI will also apply neuroergonomics the study of the human brain in relation to behavioral performance in natural environments and settings and cognitive engineering in the design and flow for the control center, Galster continued.

We have, either internally or through our existing collaborator network, the ability to offer assistance in all aspects of the operational space for this exciting project, he said.

Galster, too, emphasized that Virgin Hyperloop will provide two unique experiences one for the passenger and one for the operator.

For passengers, the RNI can examine and offer recommendations on the point-to-point experience that Virgin Hyperloop will offer, he said. Examples include digital infrastructures to help from purchasing to arriving at your destination, environmental factors such as vibration, lighting, ergonomics, motion sickness, and the use of advanced recovery modalities during ride times.

The ultimate goal, Galster said, is to make the entire system operate safely and securely with maximum efficiency and enjoyment now and in the future.

The ecosystem weve established at West Virginia University Rockefeller Neuroscience Institute is already impacting individuals across different walks of life in improving not only their health and wellness, but job performance, recovery and readiness, Rezai said. At the Hyperloop Certification Center, we will be providing a scientific leadership role and guidance in characterizing and optimizing human safety and function related to this innovative hyperloop technology.

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