Immunology

Medical student and alumni discover zebrafish are resistant to eye infection – The South End

A Wayne State University School of Medicine student and two recent graduates working on a collaborative project in the laboratories of Associate Professors of Ophthalmology, Visual and Anatomical Sciences Ashok Kumar, Ph.D., and Ryan Thummel, Ph.D., have discovered that zebrafish dont contract endophthalmitis.

The eye infection can cause blindness within hours if not diagnosed and treated quickly.

Matthew Rolain, Frank Mei, M.D. 19 and Xiao Yi Zhou, M.D. 17, contributed to the study, Zebrafish are Resistant to Staphylococcus aureus Endophthalmitis, published in Pathogens, a peer-reviewed journal in the field of microbiology and immunology.

The study showed that while humans require only 10 to 100 bugs to cause endophthalmitis, and mice require 5,000 before infection, in the freshwater fish even 250,000 bacteria wont cause the eye infection. The finding indicates that zebrafish eyes are incredibly resistant to such eye infections and possess strong host defense mechanisms.

Dr. Thummel and others in the field have shown that humans and fish share similarities in eye structure and immune responses. Studying why fish, but not human eyes, are resistant, may help identify protective pathways and molecules that could be translated to humans.

Traditionally, we have used a mouse model to study the pathobiology of these infections. In recent years, zebrafish have emerged as an important model organism in biomedical research, providing insight into the pathogenic mechanisms of infectious diseases. We sought to determine their susceptibility with the ocular bacterial infection, Dr. Kumar said. I contacted my colleague Dr. Thummel and discussed the idea, and the project took off with participation of three medical students who completed the task collectively.

Dr. Kumars laboratory focuses on understanding the pathobiology of ocular infections, especially those affecting the retina, such as endophthalmitis. The infection most often occurs due to surgical complications or eye trauma.

Apart from conducting research, I truly enjoyed mentoring these medical students, Dr. Kumar said. I hope they continue develop scientific acumen as they transition to their respective residency programs.

Matthew Rolain will graduate from the School of Medicine in 2020.

Working with Dr. Kumar and Dr. Thummel was an awesome experience, he said. They gave me great guidance and were always very supportive, regardless of the outcome of our experiments. It was nice being able to learn about the research process while working on such an interesting and potentially impactful project. Hopefully the scientific community will be able to build on our results to better help future patients.

Dr. Mei is now a resident in his transitional year in Chicago before starting a two-year Ophthalmology program at the University of Texas Southwestern Medical School in Dallas.

Individually, Drs. Kumar and Thummel were well respected in their separate expertise. However, the unification of their talents into a singular project created a collaborative environment where the strengths of both labs meshed, launching and dramatically expeditingthis project to completionin a very short timeframe. Bridging the gap between Scott Hall and the KresgeEye Institute, Drs. Kumar and Thummel created a warm atmosphere to foster my growth as a researcher. This experience was invaluableand an encouragement for me to seek further collaborations in my career in academic ophthalmology, Dr. Mei said.Lastly,I would like to thank the Medical Summer Research Project through Wayne State and the Kresge Summer Internship for supporting me through this project.

Their colleague, Dr. Zhou is a resident in her transitional year at NorthShore University Health System in Illinois. She completed a one-year fellowship at Bascom Palmer Eye Institute in Miami after graduation.

Moving forward, they plan to test zebrafish susceptibility to other bacterial and fungal pathogens.

The work was supported by grants from the National Institutes of Health (R01EY027381 and R01EY026964 to Dr. Kumar, and R01EY026551 to Dr. Thummel. Histology and imaging core resources were supported by a vision core grant (P30EY04068) and an unrestricted grant from Research to Prevent Blindness to the Department of Ophthalmology, Visual and Anatomical Sciences.

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Medical student and alumni discover zebrafish are resistant to eye infection - The South End

Immunology

Advancing cancer research – UBC Faculty of Medicine

In 2013, cancer immunotherapy was being heralded as a breakthrough in the scientific community.

This exciting development led Samantha Burugu, a recent graduate from the department of pathology and laboratory medicine, to follow her dreams of advancing cancer research.

Here she describes her PhD thesis on biomarkers in breast tumors, and shares how she is using her training to inform work with biopharmaceuticals.

Samantha Burugu is a graduate of the department of pathology and laboratory medicine.

While I was finishing up my masters degree in immunology doing foundational research, I wanted to do research that involved clinical tests conducted in hospitals. Clinical tests can be used for disease diagnoses and/or for treatment decisions. After interviewing with my doctoral thesis advisor, Dr. Torsten Nielsen, the pathology and laboratory medicine program was a clear choice. It aligned with my thesis research in biomarker development and my career aspirations.

We hear every day about increasing global incidence of cancers and that everyone in their lifetime has had, or will have, someone within their immediate circle affected by cancer. I wanted to get involved in advancing cancer research. In addition, I had trained in immunology and at the start of my program Science Magazine had just named cancer immunotherapy the 2013 Breakthrough of the Year. Cancer immunotherapy works by unleashing a patients own immune system to fight cancer and this strategy led to incredible results in some cancer patients receiving immunotherapy drugs in clinical trials.

This fall, students graduate from a range of Faculty of Medicine programs.

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Although cancer immunotherapy has led to remarkable clinical results in otherwise incurable cancers, the majority of cancers do not respond to these treatments and we still have not fully elucidated the mechanisms. My doctoral thesis focused on identifying potential biomarkers in breast tumors excised from patients that would indicate a predictive ability to respond to novel cancer immunotherapy drugs.

Using conventional and novel techniques to analyze breast tumors excised from patients, I found the presence of immune cells that can be reactivated by novel immunotherapy drugs to eliminate cancer cells. This work can inform the prioritization and design of immunotherapy clinical trials for breast cancer patients.

My advice is to not be afraid to get involved in the department and try to get the most of graduate studies. By participating in different departmental committees, graduate student associations and attending professional advancement learning series (just to name a few), not only will you build a professional network but also you will develop transferable skillsets.

A healthy community for me is where you feel a sense of belonging. In that sense, you feel respected, engaged, and encouraged by the community. Everyone in a healthy community participates in their own way to make the community better.

I have recently started working at Grifols, a plasma-derived biopharmaceutical company, as a Scientific Development Manager. As part of the Medical Affairs team, I provide medical and scientific understanding of our plasma-derived therapeutic products to health care professionals and researchers.

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Advancing cancer research - UBC Faculty of Medicine

Immunology

Cancer Immunology And Oncolytic Virology Market Opportunities and Forecast Assessment, 2021 – Downey Magazine

The globalcancer immunotherapy marketshould reach $96.5 billion by 2021 from $73.0 billion in 2016 at a compound annual growth rate (CAGR) of 5.7%, from 2016 to 2021.

Report Scope:

The scope of this report covers current cancer immunotherapy markets for most common cancers. The market segments included in this report are therapeutic monoclonal antibodies (with special focus on checkpoint inhibitors), synthetic interleukins, interferons, and colony-stimulating factors; small kinase inhibitors of cancer-related targets; protective and therapeutic cancer vaccines; and adoptive cell therapies. This report also covers treatments that are in development for late-stage and early-stage oncolytic viruses. Detailed epidemiological information, discussion of incidence and mortality trends, overview of regulatory landscapes, and analysis of market shares for leading products and companies are also included in this report.

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Report Includes:

An overview of the global markets for cancer immunotherapies and oncolytic virology. Analyses of global market trends, with data from 2015, 2016, and projections of compound annual growth rates (CAGRs) through 2021. Analyses of factors influencing market demand, such as clinical guidelines, demographic changes, and market saturation. Information covering the latest trends, market structure, market size, key drug segments, and trends in technology. Coverage of colony stimulating factors (CSFs), interferon alfa and gamma products, interleukin products and therapeutic monoclonal antibodies, including antibody conjugates, cancer vaccines, and other cancer treatment immunology products. Technological discussions, including the current state, newly issued patents, and pending applications. Profiles of leading companies in the industry.

Report Summary

Cancer is a disease with global implications. There are many different types of cancer, of which the most common types include lung, breast, colon and rectal, stomach, head and neck, prostate, cervical, melanoma, and ovarian cancer, as well as leukemia. Cancer is a genetic disease that is conventionally treated by surgery, radiation therapy, chemotherapy, hormonal therapy, and immunotherapy. Surgery is the mainstay treatment for all cancers. Usually surgery is complimented with radiation or chemotherapy to ensure the clearance of all residual cancer. Despite the advances in treatment, cancer has great plasticity; therefore, after a certain time the effects of treatment fade and cancer returns with acquired resistance. Combination therapy, using multiple modalities including surgery and pharmaceutical or radiation therapy, improves response to treatment.

Radiation and chemotherapy have many side effects. Biological treatment options provide less impactful treatment of cancer. Immunotherapy is a type of biological therapy and it incorporates elements of the immune system in cancer treatment. The immune system has various types of cells and proteins that detect and act upon signs of a disease or infection by harmful and foreign substances such as microbes, bacteria and viruses. The immune system differentiates the bodys own cells and tissues through an evolutionary bar-coding system. This system helps the immune system understand encountered foreign substances as nonself. Cancer cells are recognized as nonself as well. The immune system monitors the body for cancer and destroys when it detects a malignancy. Cancer cells can avoid being recognized by the immune system and develop resistance through numerous methods.

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Since the early 1900s, the connection between cancer and the immune system has caught the attention of various scientists and medical practitioners. Although the early studies were bluntly done without current technological and scientific tools, they nonetheless shed insights leading to the development of the first monoclonal antibodies and to the use of biologically derived synthetic interleukins and interferons. After many decades of research, immunotherapy finally emerged as a fully functionalclinical area in the 1990s. Since then, the cancer therapeutics landscape has changed dramatically.

With the stream of product approvals in recent years, the global immunotherapy market has reached its current value. In 2015, the global cancer immunotherapy market hit $65 billion. The current immunotherapy market contains several blockbuster products reaching their end-of-market exclusivities; however, the market is mostly comprised of newly introduced and expensive therapies. In 2016, the market expanded by more than 10% over the previous year, reaching $73 billion. During the period of 2016 through 2021, the global cancer immunotherapy market is forecast to grow by a 5.7% compound annual growth rate (CAGR), reaching $96.5 billion in 2021.

The strongest growth is expected to occur in checkpoint-inhibitor drugs with a 19.4% CAGR during the forecast period. Immunomodulators are anticipated to show the second-highest growth rates among immunotherapy products, with an 8.4% CAGR during the same period. The combined sales from both segments are expected to make up for nearly one-third of the market, with a combined sales value of $28 billion in 2021. Checkpoint inhibitors are virtually comprised of monoclonal antibodies; however,they are assessed separately due to their immense commercial and clinical significance. Sales from other therapeutic antibodies accrued to $28 billion in 2016, and this value is expected to remain relatively constant through 2021, due to several patent expiries, pressure from anticipated generic entries, and newly introduced classes of drugs expected by 2021.

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Cancer Immunology And Oncolytic Virology Market Opportunities and Forecast Assessment, 2021 - Downey Magazine

Anatomy

Jon Batiste: Anatomy of Angels: Live at the Village Vanguard – Relix

Jeff Tamarkin on November 27, 2019

At 35 minutes, Jon Batistes Anatomy of Angels: Live at the Village Vanguard could be described more as an EP than a full-length album but, despite its brevity, it packs in plenty of impressive musicality. Recorded at the venerable New York City jazz club with the rhythm section of bassist Phil Kuehn and drummer Joe Saylor of Stay Human, the pianists band from The Late Show with Stephen Colbert , the program features a potent battery of guest horn players. Also joining the proceedings is the always-welcome Lake Street Dive vocalist Rachael Price, who offers a sultry and bluesy ballad version of Ray Nobles chestnut The Very Thought of You. Batiste accompanies Price solo on this one, and its a most effective presentation on the slowed-down form; the pair would undoubtedly make a terrific duo on a full album or cabaret concert should that urge ever strike them. The only other cover here is an octet arrangement of Monks Round Midnight, which Batiste and his band somehow manage to give a fresh coat of New Orleans paint without losing sight of the original elements of the tune. That leaves three Batiste originals, led off by Creative, which previously launched his 2013 Jazz Is Now album and takes on an additional layer of free expression here. But its the album closing, 13-minute Anatomy of Angels that utilizes everything this collective has in their arsenal, ranging from Coltranesque manic ranting to a more subdued, blues-infused simmer.

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Jon Batiste: Anatomy of Angels: Live at the Village Vanguard - Relix

Anatomy

Abigail Spencer and Costar Kevin McKidd Would ‘Burst Into Song’ On Grey’s Anatomy Set – PEOPLE.com

Abigail Spencer and Costar Kevin McKidd Would 'Burst Into Song' On 'Grey's Anatomy' Set | PEOPLE.com Top Navigation Close View image

Abigail Spencer and Costar Kevin McKidd Would 'Burst Into Song' On Grey's Anatomy Set

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Abigail Spencer and Costar Kevin McKidd Would 'Burst Into Song' On Grey's Anatomy Set - PEOPLE.com

Anatomy

You’ll never guess which former Grey’s Anatomy actor got a show on Fox News’ streaming service – The A.V. Club

Photo: Frazer Harrison (Getty Images)

12 years after getting fired from Greys Anatomy for calling co-star T.R. Knight a homophobic slur, Isaiah Washington is going to the exact place where youd expect him to go: Fox News. Well, technically hes going to the companys Fox Nation streaming service, but thats basically just Fox News with less prestige. This unsurprising news comes from The Wrap, which says Washington will host an untitled travel/cooking show where he cooks with everyday Americans and celebrities inside their own kitchens. Along the way, theyll chat about their cultures, traditions, and the 2020 election. So make that an untitled travel/cooking/politics show, which just sounds like a blast when you consider the caliber of celebrities that are going to want to appear on Fox News streaming platform with the guy who got fired from Greys Anatomy.

The Wrap points out that Washington has made an effort to do fewer homophobic things since 2007, joining other Hollywood-types in public condemnations of anti-LGBTQ legislation, and hes also been an advocate against police brutality. That being said, hes also become a bit of a Trumper recently, with Newsweek reporting that he gave an interview to Fox Nation earlier this year in which he noted that there are a lot of conservative or centric libertarian-minded [famous people] that really care about other people, but theyre afraid to come out of the closet as conservativeswhich is an extremely fun choice of words for, you know, the guy who got fired from that show for doing the thing he did.

Washingtons Fox nation show doesnt have a premiere date yet, but if youre the kind of person reading this, youre probably not the kind of person who actually wants to watch it. If you are, though, feel free to leave a mean comment below.

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You'll never guess which former Grey's Anatomy actor got a show on Fox News' streaming service - The A.V. Club

Anatomy

‘Sacred’ ceremony at University of Minnesota honors those who donated their bodies to science – Minneapolis Star Tribune

Norma Telander took her Scrabble seriously. On the rare occasion when her grandchildren or great-grandchildren bested her, they knew they had won honestly. Telander was too competitive to throw a game, even to her beloved family.

She beat me right before she died, when she was 96 and in transitional care recovering from a broken hip, said her granddaughter Laurie Bauer. She was always such fun, so generous. Thats the core of who she was.

On a recent evening, 10 members of Telanders intergenerational family climbed the steps of Northrop auditorium to attend the Academic Health Centers annual Service of Gratitude. The ceremony, which included performances by medical students, paid solemn tribute to the 688 people who, like Telander, bequeathed their bodies to the University of Minnesota in the past year.

They made a brave and selfless decision, Dr. Mark Rosenberg, vice dean of education at the medical school, said as he thanked families and friends of the donors. In life, they were barbers, firefighters, nurses, homemakers. They are united in death as teachers.

Those who become what are called whole body donors choose to leave their physical remains to be used for education and research purposes. At the U of M, cadavers are used in anatomy courses required for medical and dental students and those preparing for careers as physician assistants, physical therapists and other medical careers.

Current health care practitioners learning new surgical techniques, researchers pioneering clinical breakthroughs and medical device companies preparing new approaches also rely on donor bodies to advance their work.

What our students and researchers learn from the gifts will impact health care outcomes in their communities and around the world, said Angela McArthur, director of the universitys Anatomy Bequest program.

Although the program hosts the Service of Gratitude, the students who spend long days dissecting cadavers in the anatomy lab are responsible for its production from greeting family members as they arrive to performing for them.

Uriel Vasquez Rios, 27, in his first year in the Us School of Dentistry, led the committee that sought Health Science Center students to participate in the event.

Rios said it was gratitude that motivated him to take on the task. Hed been studying human anatomy from two-dimensional illustrations, but that paled in comparison to what he is learning by working from a human body.

You see the variations and learn about size and texture when you actually grasp the organs, bones and muscles, he said. When I used my scalpel to go through the tissue for the first time, I realized that without the gift from this person I wouldnt have this opportunity.

My future patients will benefit because I have this foundation.

Schooled in respect

Ben Byun and Paul Cho are in the first semester of their first year of medical school. Theyre still adjusting to jammed days and a punishing study schedule, but the classmates, both 23, carved out about 20 hours to rehearse a demanding musical piece to perform at the Service of Gratitude.

They played Sicilienne a Gabriel Faur composition that gained renewed fame when it was played at the wedding of Prince Harry and Meghan Markle.

Performing it is a labor of love, said Byun, a cellist. We put time and emotion in preparing and its taken effort; its not simple. Its a small, nonverbal way of saying thanks.

The pair of doctors-in-training played their best, knowing that members of the audience are likely related to the bodies assigned to them in the anatomy lab.

At first were cautious; cutting is so unnerving and foreign. In every person we see differences that books dont teach you, the variations in the fat and the skin and the connective tissue. You have to get comfortable so you can do what youll need to do, said Byun. As it becomes more familiar, you feel a connection to the cadaver.

Before any student picks up a scalpel, they have been schooled by faculty members in a culture of respect.

Our instructors instill in us that this is someones loved one. They remind us to think about how we would want to be treated if we were a donor, said Cho. What we do is profound and powerful.

Sacred and stirring

Jean Larson, a volunteer advocate for the Anatomy Bequest program, has become a regular presence at the annual Service of Gratitude. She first attended in 2015, when her husband of 60 years was recognized for his whole body donation.

This ceremony is stirring and sacred, she said. Its meant to be a thank-you from the students to us, but I am here offering my gratitude back to them, for how graciously they treated us in every step of the process. Im thankful for the service. Im thankful they show their thanks.

Now 84, Larson has formalized plans to leave her body to the university.

Its the thing to do, she said. I believe in medical advancement. I wouldnt want a surgeon working on me who hadnt seen inside a human body.

The highlight of the service was a slide show of the donors. Each appeared in a larger-than-life image projected onto a screen.

They smiled in formal portraits likely lifted from church directories or in candid snapshots a proud mother of the bride, a pastor in a clerical collar, a serviceman posing in his military uniform, a fisherman driving his boat on a bright summer day.

And then there was the picture of Norma Telander, sitting in front of her Scrabble board.

When her image appeared on the screen, the Telander family issued a collective gasp. A few shed some tears.

My life was enriched by her. I miss her terribly, said stepdaughter Barb Heilman. But it was an amazing tribute. This felt like a celebration and, oh, it was so touching. So good to see her again.

Kevyn Burger is a Minneapolis-based freelance broadcaster and writer.

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'Sacred' ceremony at University of Minnesota honors those who donated their bodies to science - Minneapolis Star Tribune

Anatomy

Grey’s Anatomy: The Main Characters, Ranked By Intelligence – Screen Rant

Grey's Anatomy is currently in its 16th season, which means that we have seen a lot of doctors come and go. They didn't all receive high marks, but others excelled in the field. These characters are intelligent and creative in their thinking as they came up with new ways to treat and care for patients throughout the show.

RELATED:Grey's Anatomy: Most Hated Supporting Characters, Ranked

We have identified the most intelligent main characters that have ever been on the who and ranked them based on the facts. The things they did, both good and bad, have been taken into consideration as we decided our ranking. Keep reading to learn the intelligence ranking of10 of Grey's Anatomy's main characters!

There will probably be more than a few who disagree with even putting him on this list when there were so many greats like Preston Burke, Richard Webber, Erica Hahn, or even Addison Montgomery. We would have agreed with you if he hadn't taken up his most recent venture at Pacific Northwest Hospital.

Yes, he managed Grey-Sloan Memorial Hospital in Bailey's absence and managed to hold the pieces together, but what he is doing here is an intellectual feat. He is turning this hospital around by lowering the mortality rate, convincing star doctors to work for him, and finding creative solutions to problems he didn't know existed.

This is another argument that Mark Sloan should hold this spot instead of Jackson Avery, but he lived more off of his legacy of being a great surgeon. Jackson, on the other hand, was intuitive in finding creative solutions to problems, which is exactly why McSteamy passed the plastic surgery torch down to him.

They are still using his Tilapia skin idea in the newer seasons on burn victims, and he is still performing incredible operations on patients with deformities that need plastic surgery to help them live a normal life. He never let the money he inherited get in his way of helping those in need, which is the most intelligent thing of all.

Owen Hunt is a veteran army surgeon who takes the practices he learned on the job into the Emergency Room. His intellect is in the form of quick thinking and coming up with creative solutions to new problems.

When he entered the show he had performed a tracheotomy with a pen, and he even knew when it was time to step away from his role as Chief of Surgery. His love life might be a complete mess, but as a surgeon, he is the only one we would want to see if we went to the Emergency Room.

Miranda Bailey is the queen of the show, and part of that is because she is so intelligent. She managed to claw her way up the ladder to Chief of Surgery after training utter disasters to become superstar surgeons. They are now some of the best in the country, and even the world and Miranda is the only one we can thank for that.

RELATED:10 Episodes Of Grey's Anatomy That Aged Poorly

It is a skill that many other characters lack in the show, but she is also gifted in the Operating Room as well. She created an invention nicknamed the Trail Blazer, which was a rectal access port for a hydro colonoscopy.

Amelia Shepherd might seem like she is all over the place at times, but she is an incredible surgeon. She has removed Dr. Herman's massive tumor which everyone believes isn't a possible feat. Amelia even puts herself in danger during the surgery by bare handing a radiation seed so she can place it.

Luckily, it doesn't make her sick and Dr. Herman ends up waking up after the lifesaving surgery to live her life, even if it is without sight.

Maggie Pierce is a phenomenal surgeon, but her performance after recent episodes has put her further down the list. She graduated from medical school early and became the Head of Cardiothoracic Surgery in record time.

She deserves the position as she is one of the best surgeons in her field, and it comes as no surprise with Richard Webber and Ellis Grey as her parents. She recently started doubting herself after the failed surgery on her cousin, but we have hope that in the end, it will make her a better surgeon.

Arizona Robbins was a rockstar pediatric surgeon who transitioned into a neonatal surgeon under the direction of Dr. Herman. It already takes an intelligent mind to enter and succeed in this field, but there was an added pressure due to Herman's illness.

RELATED:Grey's Anatomy: Most Heartbreaking Deaths, Ranked

She was rushed through the training because of the time constraint, and she managed to excel despite these complications. It is something only someone with extreme intelligence could do, which is why she is ranked so high on our list when there are so many other great options.

Derek Shepherd, or McDreamy as most people know him, was an all-star before his unfortunate passing. One of his greatest works, even if it was destroyed by Meredith, was in the field of Alzheimer's. He had created a drug that would prevent the nerve cells in patient's brains from dying.

He was also a phenom in the operating room and even made it his mission to take on hopeless cases. Derek was an inventor as well as he helped Callie create robotic limbs that could respond and move through mind control.

Cristina Yang was not only Preston Burke's greatest student, but she was an amazing cardiothoracic surgeon and inventor. She saved Derek's life after he was shot in the chest and she enjoyed pushing the limits of modern medicine by trying new and less invasive techniques.

She was even nominated for a Harper Avery Awardfor her work on creating 3D conduit hearts for children. She eventually moved to Switzerland to continue her work and no one else on the show except our number one has as much intelligence or drive as she does.

Meredith Grey is the most intelligent character on the show, despite her lack of judgment when her heart gets in the way. When she was a resident she was set on neurosurgery, and then later changed to general surgery which are hard fields to enter.

RELATED:Greys Anatomy: 5 Best Friendships (& 5 Worst)

She has won a Harper Avery Award for herALPPS procedure when she successfully performed this surgery on Owen Hut's sister. Her work didn't stop there as she continued to start a project with mini livers to help people suffering from liver disease.

NEXT:10 Characters On Grey's Anatomy That Are Actually BF Worthy

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Grey's Anatomy: The Main Characters, Ranked By Intelligence - Screen Rant

Anatomy

Stan Drops A Bunch Of Iconic Shows Including ‘Greys Anatomy’ And ‘Buffy The Vampire Slayer’ – 10 daily

Cancel your plans and get the popcorn ready, because Stan just announced they'll be streaming a bunch of iconic TV series and it's legen-(wait for it)-dary.

Just when we thought we'd binged enough TV shows to have us set for life, Aussie streaming giant Stan has announced they've added a slew of iconic television shows to their platform for your viewing pleasure.

Among the drop includes cult series 'Buffy The Vampire Slayer' starring Sarah Michele-Gellar in the role that catapulted her into fame.

You'll also get the chance to rekindle your love for McDreamy with the release of 'Grey's Anatomy', roll your eyes over Ted Mosby's questionable life choices with 'How I Met Your Mother', or lust over bikie bad boy Jax Teller on 'Sons Of Anarchy'.

On top of all this TV goodness,for the first time ever in Australia, viewers will also now be able to stream 'Family Guy'.

Fans are already voicing their excitement over the nostalgic content, with one Twitter user declaring, "Stan added HIMYM and buffy omg the serve," adding, "also charmed and friends honestly stan is beating Netflix in iconic content".

Another added, "IT FINALLY HAPPENED @StanAustralia has Buffy.I may have lost hope in human beings this past week but I can always rely on Stan to make my future life as a hermit the best life."

In a time where streaming heavyweights such as Netflix and Disney+ are battling it out for the best content, Stan is also staking its claim for your binge-watching dollars.

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Stan Drops A Bunch Of Iconic Shows Including 'Greys Anatomy' And 'Buffy The Vampire Slayer' - 10 daily