Opinion: Why Republicans will stick with Trump in 2020 – Los Angeles Times

Recently, a close friend and fellow Republican told me he was personally shocked at what the evangelicals have been willing to stomach from Donald Trump. Im not shocked at all.

My friends sentiment a variation on the empty if Obama had done this, Republicans wouldve impeached him has become a staple of Democrats and Never Trumpers. Are you ready to turn on him yet? Republicans are asked over and over.

No one ever says yes. The Republicans who make a living hating Trump today hated him before he was elected. The rest of the party remains solidly behind him. The reason for that, as we enter this election year, is less granular than feeling happy or sad about a specific presidential behavior. Rather, it has to do with the general direction of the nation: Trump and whoever the Democrats nominate represent such fundamentally different directions for our country that it is almost unthinkable for a Republican voter to be seriously torn.

Imagine standing at a train station in Louisville, Ky., staring at the schedule board. You want to get to Los Angeles, and you have a choice of two trains one headed to San Diego and one headed to Washington, D.C. Neither gets you exactly where youre heading, but theres really only one choice as the alternative to San Diego is to go precisely the wrong way.

Even if the San Diego train sometimes hits bumpy tracks, and the conductor comes on the PA and says crude and dumb stuff, and there are people on the train you really wish would get off: It is still taking you basically where you want to go.

To the average Republican voter, like the passenger on that train, the destination is what matters.

I tried to explain this to my friend. I told him that, for Christian conservatives, the choices are Trump versus people who prefer full-term abortions and believe that that our country should functionally have no borders. To vote against Trump is to vote for a party that fundamentally believes Republicans are deplorable and racist.

The decision isnt hard.

But the porn stars! The crudeness! The immorality! my friend says.

To a Christian conservative voter, the individual behavior of an imperfect human pales against the importance of protecting human life. If the imperfect president appoints pro-life judges and takes your values into account when making policy, you dont worry so much about one sinners struggles with morality. You just pray for him, while also giving thanks for all he does to advance your cause.

Choosing any of the Democrats running for president isnt simply boarding a train headed in a slightly different direction, or one going the same way with a nicer conductor. It means completely turning around. For goodness sakes, Elizabeth Warren and Joe Biden have both proposed plans that would spend taxpayer dollars on gender assignment surgery!

And thats what has been so illuminating about this Democratic primary race: Because of their extreme tilt to the left, none of these candidates have a prayer of peeling off a statistically significant number of Republican voters. No matter what the Never Trumpers in your Twitter feed tell you, Trump win or lose will have the support of more than 90% of his party.

Some people used to argue that the two parties are basically the same. It wasnt true then, and its especially not true now. Most of Trumps governance has been what youd expect from any Republican president (conservative judges, lower taxes, deregulation, an embrace of pro-life policies), and the wild extremism of his would-be opponents is causing some center-right voters who were lukewarm on Trump three years ago to feel closer to him than ever before.

The exception to that is the cohort of suburban women who clearly abandoned the Republicans in the 2018 midterm and strongly disapprove of Trump now. But will losing them be enough to derail the Trump train?

I consulted the impeachment polling aggregator on Nate Silvers FiveThirtyEight website on Dec. 29, and it said that 48% of Americans prefer impeachment and removal versus 46% who did not. As has been true for three years, the polls say men basically want Trump and women basically dont.

Impeachment has become a political Rorschach test, and Trump might easily win reelection with a two-point deficit in the popular vote. The question isnt how Republicans can still vote for Trump, but how the Democrats became so radicalized as to present no viable alternative to huge swaths of nonurban America.

Scott Jennings is a former advisor to President George W. Bush and Senate Majority Leader Mitch McConnell and a CNN contributor. He is a contributing writer to Opinion. Twitter: @ScottJenningsKY.

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Opinion: Why Republicans will stick with Trump in 2020 - Los Angeles Times

Alexandria mayor names acting chief as ousted chief’s backers call for support – The Town Talk

Alexandria Mayor Jeff Hall has named an acting police chief as opposition to his administration placing Jerrod King on leave got louder with his supporters calling for citizens to push back.

Hall, in a release sent out Sunday, named Alexandria Police Department Assistant Chief Farrell Gaspard as the acting chief.

A message on an electronic billboard near the Jackson Street and Versailles Boulevard intersection shows support for Chief Jerrod King, who was placed on leave Friday.(Photo: Melissa Gregory/The Town Talk)

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Hall stated he thought Gaspard, a 32-year veteran with the department and Mansura native, would ""do an outstanding job in this role.

King, named chief in May 2018 by former Mayor Jacques Roy, was placed on administrative leave on Friday. No reason was given, and a city spokesman said itcouldn't be discussed since it was a personnel matter.

Acting Alexandria Police Chief Farrell Gaspard(Photo: Courtesy/city of Alexandria)

Just days before, on New Year's Eve, had King posted a message on his personal Facebook page to the department's officers. He wrote that the past year had been exciting and challenging.

"Together, we have faced critical issues ranging from manpower concerns, budgetary constraints, and concerns of financial compensation for you, to what sometimes seems to be a continual display of the worst in human behavior," he wrote. "Despite all of the obstacles and issues that have arisen along with facing the evil that all of you confront on a daily basis you have remained true to our departmental values of Service to Others, Honor, Integrity, Excellence, Loyalty, and Dedication."

The message also wished his officers and their families peace, prosperity and happiness for 2020.

"It has been my distinct honor and absolute privilege to serve as your Chief this past year. None of us know what tomorrow may hold but I want to assure you that I am and will always be extremely grateful to each of you, the men and women of this department, and to your families for allowing me to serve as your Chief."

King's supporters on Saturday unveiled a Facebook page, AEX4King, asking residents to show their support. They called upon residents to attend Tuesday's Alexandria City Council meeting to support King.

The page has garnered more than 1,200 likes since its debut on Saturday.

Supporters also paid to post a message of support on at least one electronic billboard on Jackson Street.

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Alexandria mayor names acting chief as ousted chief's backers call for support - The Town Talk

Should Tesla Take The Initiative To Better Monitor And Manage Driver Behavior With Autopilot? – Forbes

A video call while a car is driven by an autopilot. Is there a need to couple driver monitoring with ... [+] collaborative automation?

By any account, Teslas Autopilot feature has come a long way since being released to consumers through an Over-The-Air (OTA) update just over 4 years ago. At inception, it was at best an incredibly sophisticated bootstrapped system based upon a Mobileye sensing platform and limited processing capabilities. With Teslas newer computing and data platforms, Autopilot is clearly one of the worlds more complex and impressive applications of a learning based Artificial Intelligence (AI) system.

The safety of Autopilot continues to be questioned by experts worldwide. A recent letter from Senator Markey to Elon Musk adds to an already heated conversation. In a post earlier this year on the Tesla automation strategy, I raised the question of whether it is appropriate for consumers to be used as test subjects, the need for a well validated measure of risk associated with the use of Autopilot, and the need for camera-based driver monitoring to manage inattention. In the months since, visuals in the media of drivers falling asleep, engrossed in non-driving activities, and otherwise participating in inattentive driving continue to appear. Seemly random, but realistically predictable, crashes keep happening that might be preventable with camera-based driver monitoring and driver management.

The reason crashes are predictable is that humans have long been known to be poor overseers of highly automated systems. When a supervisor feels that the automation is trustable, the irony is that there will be an increase in the number of system failures that are not mitigated correctly by a human supervisor. It simply becomes increasingly difficult to sustain attention as automation becomes more reliable. There is a painful history in transportation safety showing this. Recently, the National Transportation Safety Board (NTSB) detailed these types of failures in investigations of several Autopilot crashes and the tragic 2018 Uber fatality.

Perhaps paradoxically, it could be argued that with the explosive use of Autopilot, we would expect to see more crashes. However, the work from the late Raja Parasuraman and his students would suggest that imperfect automation (like Autopilot) keeps many users from becoming too complacent. In essence, its possible that the failure of a few individuals to appropriately oversee and collaborate with the automation is mixed with more responsible use by many.

This is not a new phenomenon for automotive engineers. It has long been known that it is difficult to engineer for all. Some drivers choose to speed, pick-up their phones, and be otherwise irresponsible with respect to other drivers with which they share the road. Are close-calls and crashes with Autopilot really more frequent than other cases of attention failures? Or are they just more easily associated with the evolution of a new and perhaps transformative (and perhaps over marketed) technology? Over the coming years there will likely be many efforts to better understand, and arguments around answering, these formidable questions. One clear difference from the introduction of previous generations of automotive systems is that todays social media driven society is helping to highlight problematic events.

The images and video that accompany todays social posts have increasingly brought what was once largely hidden from public view into the limelight. This naturally presses consumers, safety advocates, regulators and even politicians into a position of judging the social ethics of how technologies are implemented.

Given this new reality, Senator Markys letter to Mr. Musk questioning if Tesla is tracking or monitoring online videos to learn about inappropriate use of the Autopilot, is right on track. Something else to consider is that Tesla Model 3s are equipped with a cabin camera. Might Tesla use this sensor, and a fraction of their technological image processing prowess, to better gauge the state of drivers? Even a rudimentary driver monitoring system might be able to detect an outright inattentive driver asleep at the wheel or head down for seconds on end.

Manufacturers such as GM and BMW have introduced camera-based driver monitoring and management systems with the launch of their collaborative driving systems (i.e., SAE L2). One has to suspect other manufacturers will follow this seemingly reasonable route to market, bridging the time till automated systems that do not depend on attentive human back-up are truly available.

Just as outliers may be responsible for the majority of risky behavior associated with Autopilot, might Tesla be passively accepting undue risk compared to the rest of the market? Growing evidence suggests that Autopilot is placing drivers, and perhaps the automotive industry, in a precarious position. The aviation industry has long known that one airlines accident impacts trust in all airlines.

With a call to reinvent driving through the greater use of automation, is it time for the automotive industry to collaborate to increase the likelihood that the introduction and refinement of these technological approaches to making driving safer in the years ahead will have the greatest potential to succeed?

Following efforts in Europe, and using a framework similar to the NHTSA-IIHS collaborative industry agreement on AEB, could manufacturers and the government come together to take another step forward in safety by collaboratively agreeing to install camera-based driver monitoring systems to work alongside collaborative driving features?

Some might argue that a detailed, performance-based standard for systems is needed. However, starting with a fairly broad and open concept may be a more realistic starting point, and a Federal Motor Vehicle Safety Standard (FMVSS) could be more easily justified as experience is gained and the cost / benefit justification of a standard emerges. Working together to develop guardrails around the deployment and testing of automation on public roads might be the most important step to accelerate the adoption of potentially lifesaving automated vehicle technologies.

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Should Tesla Take The Initiative To Better Monitor And Manage Driver Behavior With Autopilot? - Forbes

Sticking to New Year’s resolutions: Turn goals into habits – Inverse

As the new decade begins, you probably came up with a few resolutions worthy of a decade where humans will push the limits of space exploration and A.I. will become less of an abstract and more of a central part of human life. If you made a New Years resolution, youre also probably aware of the pessimistic statistics that surround them.

Humans have been making New Years resolutions for about 4,000 years, when the Babylonians took an opportunity to repay their debts or return items theyd borrowed during a festival called Akitu. Despite millennia of vowing to be better, humans are not any better at keeping our resolutions than we were 4,000 years ago. Research done in the 80s found that only 43 percent of people stuck to their resolutions after three months.

A version of this article first appeared as the Strategy. Sign up for free to receive it weekly.

That bleak history doesnt speak to the futility of resolutions; they just show how hard it is to change our behavior. Humans tend to prefer default options, whatever they may be This is sometimes called status quo bias.

Behavior change is at the heart of basically any New Years resolution you have, which is one of the reasons keeping them feels so hard. To combat that, you have to learn to take a resolution and turn it into a habit you dont have to think twice about.

One expert in habit formation tells Inverse theres no way to hasten the process, but there are ways to set yourself up for success.

Phillippa Lally is a senior research fellow at University College Londons Department of Behavioral Science and Health. In 2009, she published a paper intended to show just how long it took 96 people to form a new eating, drinking, or exercise habit from running for 15 minutes before dinner to drinking a glass of water after breakfast.

That paper, which has been cited over 1,000 times in the intervening 11 years, found that the average amount of time it took for these goals to become habits was 66 days.

Lally tells Inverse that 66 days isnt the magic bullet for habit formation as it appears to be. She found that some people were able to form habits as quickly as 18 days, whereas for others it took as long as 254 days. Instead, the most important thing her study identified is that habit formation follows an asymptotic curve:

This curve shows the relationship between doing your chosen activity and the automaticity of that activity which is basically when you start to feel an impulse to perform that activity. (Her team used surveys that evaluated automaticity on a scale of 0 to 42.) If you look at the early days of the experiment, you can see that there are big jumps in automaticity. But over time those jumps get smaller and smaller and the curve starts to plateau.

With each subsequent repetition, the increase is a bit less, until you reach a point at which the behavior has reached its peak of automaticity. And with each new repetition, the automaticity you experience when you enter the situation remains stable, Lally says.

Once you hit that peak, the automaticity gains start to plateau. Thats the point at which your resolution has transformed into a habit.

You can consider the time it takes people to reach this plateau to represent the time it takes their habit to form, she says.

That 66 days is just a ballpark measure to give you an idea of how long the road to habit formation actually is. To get to that plateau, her advice is to try to be as consistent as you can.

Inevitably, you will miss an opportunity to perform your habit of choice. If youve decided to run every morning, youll sleep in or take a well-deserved day off. Fortunately, Lally says this wont set you back very much. Missing just one day of an activity reduced a persons automaticity score by .29, a very small decrease that didnt have any major consequences in the long term.

In the paper, the team points out that missing larger chunks of time, like a week, can significantly derail habit formation. So, again, theres no shortcut for consistency.

Finally, take heart in the fact that you make the biggest automaticity gains right out of the gate. That means you can use these early days of January, when youre feeling newly inspired to pursue new goals. Every time you actually follow through on your resolution, youre putting money in your automaticity bank and setting yourself up for success once the new year loses its shine.

Lally says that the best way to apply her work to a New Years resolution is to frame that goal in a specific way. Once you decide what your goal is, you need to find a cue for that goal.

In her study, people were told to bake that cue into their goals. They pledged to do 50 sit-ups after my morning coffee or go for a run before dinner. That time element is a situational cue that should trigger that behavior.

The cue doesnt have to be time-oriented, but it does have to be recognizable enough that it becomes associated with the desired behavior in your mind.

It is crucial that there is a cue for the behavior. Otherwise, the behavior could be performed in various situations and a habit wont form, says Lally.

From there, she recommends that you follow this formula to write down your goals:

In situation X, I will perform behavior Y.

This type of structure, says Lally, is called an implementation intention. Instead of pledging to go to the gym more, frame it like this: After work on Tuesday, I will go to the gym.

Then, repeat the desired behavior as many times as possible when you get into situation X. That way youll start working your way along the asymptotic curve and move towards the plateau of automaticity.

Though Lally describes herself as quite a routine person, shes taught her daughter about implementation intentions by asking her to repeat her goals aloud using the in situation X, I will perform behavior Y format:

If I ask her to remind me of something later, she will make a plan and repeat it aloud three times. For example, When we get home, I will remind mummy to put the washing on.

Talking out loud to yourself or writing down your goals is a method that expert musicians also use to learn new skills. In this case, it can help you pursue the automaticity that turns a resolution into a habit.

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Sticking to New Year's resolutions: Turn goals into habits - Inverse

How Economists Tricked Us Into Thinking Capitalism Works – Truthout

These days, it seems like someone is always trying to privatize something. One day its the Trump administration contemplating the privatization of the Department of Veterans Affairs. The next its the Tories looking to sell off the U.K.s National Health Service, or economists promoting market-based solutions to the climate crisis. In this age of neoliberalism, the rallying cry for politicians and economists alike is always for More privatization! More markets! Sell it all off to the private sector!

Of course, much of the time this faith in the market is used as a cover by those looking to simply make a profit or by the politicians representing their interests. But this is not always the case. There are many who actually believe, wholeheartedly, that markets are the most efficient and even the most ethical way to run a society. And because this is the worldview that is taught in the vast majority of economics departments throughout the world, its not surprising that this is the dominant worldview among those in power.

Its an ideology that was carefully crafted during the time of the early Western economists like Adam Smith and David Ricardo. Homo sapiens are actually Homo economicus, the theory goes: selfish, competitive, rational agents who are all constantly seeking to efficiently maximize their own personal well-being.

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No need to despair, however, because economists have figured out that these inherent traits can actually be utilized for good, through a social relation known as the market. By its nature, the market encourages competition and efficiency, and thus, by relying on the self-maximizing behavior of individuals, market capitalism is the only economic system that truly accepts human nature for what it is. And in fact, its the only system uniquely situated to actually channel this nature into a net positive outcome for society.

How does this all work? Well, when they are free to make choices that maximize their own interests, people in a market system negotiate on a price and quantity of a product or service until a sort of equilibrium is established. Its a natural process of compromise that leaves everyone satisfied and also leads to an efficient way of producing and distributing goods and services. Everyone wins. And, the theory goes, it just so happens that the process aligns perfectly with human nature. Its a fascinating theory. The only thing is, its completely wrong.

The foundation of this theory relies on an assumption about human nature that has been discredited over and over by research across multiple scientific disciplines. It turns out that Homo economicus is a fairytale, an outdated misconception, a gross distortion of reality. Yet, it still serves as the theoretical foundation of our entire economic system.

Studies have determined that the Homo economicus personality is an extremely rare one. Instead, most humans are marked by a deep capacity for reciprocity, cooperation and selflessness. For example, research shows that by 14 months of age, children are already beginning to help each other by handing over objects that others are unsuccessfully reaching for. This empathic behavior only increases as children grow older and begin to share things that they value with others and even object to other peoples violation of social norms.

These are all early signs of prosociality behavior that is marked by an intent to help or benefit others. And importantly, this behavior is motivated by a genuine concern for others and not by selfishness.

Evolutionary biologists have also largely debunked the theory of Homo economicus. Researchers like David Sloan Wilson and others have determined that more prosocial groups will robustly outcompete less prosocial groups, meaning that prosociality was an advantageous trait when it came to the natural selection of early humans. And these theories are not new. Over a century ago, the anarchist theorist Peter Kropotkin wrote convincingly on how the survival of our species has depended more on cooperation than on the heroic efforts of isolated individuals. It certainly is difficult imagining an early human taking down a woolly mammoth without engaging in highly coordinated prosocial behavior. How else could the human species evolve to dominate the globe if not by cooperating with one another to overcome the many challenges our species faced?

Another place where we see the myth of Homo economicus debunked is in the research that comes out of post-disaster communities. In her landmark book, A Paradise Built in Hell, Rebecca Solnit presents a thesis arguing that humans have an innate capacity toward collectivism and that these traits tend to reveal themselves most strongly in community response to disasters. Far from resorting to antisocial behavior after a disaster (a myth which the media tend to elevate), Solnits book outlines enumerable instances where communities demonstrate prosocial behaviors like cooperation, solidarity, sacrifice and generosity instead.

In the wake of an earthquake, a bombing, or a major storm, most people are altruistic, urgently engaged in caring for themselves and those around them, strangers and neighbors as well as friends and loved ones, Solnit writes. Decades of meticulous sociological research on behavior in disasters, from the bombings of World War II to floods, tornadoes, earthquakes, and storms across the continent and around the world, have demonstrated this.

Yet, despite the overwhelming evidence contradicting it, weve come to accept Homo economicus as the truth. Perhaps not always consciously, but it haunts our dreams, our imagination. It confines our sense of possibility and imposes boundaries as arbitrary as those that carve up ecosystems and communities into nation-states.

Market capitalism has been imposed onto us, often at the point of a gun, and as a result, weve been forced to internalize the idea that we are a selfish, competitive and greedy species. Well, thats just human nature, well acquiesce when we hear about the profiteering of pharmaceutical companies or the greed of investment bankers. But the thing this, thats not human nature its just what weve been coerced into thinking by an unfeeling economic system that dominates every facet of our life. And in many ways, Homo economicus is a self-fulfilling prophecy.

Its been demonstrated that studying economics actually makes you more selfish. Studies have shown that economics students are much less likely than other students to donate money that was given to them into a common pool; that they are more likely to freeride and are also more likely to defect than to cooperate; that they are more likely to participate in deception for personal gain; and even that they are more likely than their peers to rate greed as generally good, correct and moral.

And its not just students: economics professors give less money to charity than professors in other fields including history, philosophy, education, psychology, sociology, anthropology, literature, physics, chemistry and biology.

When faced with the overwhelming evidence that Homo economicus and thus the whole neoclassical economic project is nonsense, the defenders of the status quo tend to rely on another myth: that there is no alternative. Margaret Thatcher famously uttered those words over 30 years ago, paving the way for an age of neoliberalism that has seen the dismantling of the social safety net, the stagnation of wages and the rise of extreme inequality.

But the thing is, there are alternative ways of organizing society that reflect the human capacity for reciprocity, selflessness and cooperation. The worker cooperative model promotes equity and democracy by giving workers ownership and control over their workplaces. It does so in a way that not only aligns with our inherently human traits, but in a way which has been shown to be more efficient and productive than the traditional workplace models.

There is also the commons model that reflects how communities organized themselves for thousands of years before they were torn off their land in the enclosure acts of 17th-century England. The commons are a way of organizing production and distribution where resources are held in common and are accessible to every member of society to be managed collectively for the benefit of all.

In fact, the political economist Eleanor Ostrom actually won the Nobel Prize in Economics in 2009 for disproving the long-held belief known as the tragedy of the commons, a theory which held that resources held in common by communities would naturally be overused and depleted. Ostroms work demonstrated that this assumption is false, and that it is in fact very possible for resources to be managed collectively without privatization.

There are many ways that community resources can be collectivized instead of privatized, from land trusts that take land off of the market to policy proposals like Medicare for All, which represents a major shift in how we view our collective responsibility when it comes to health care, or the Green New Deal, which recognizes our collective responsibility to prioritize climate justice in the fight against climate change.

The alternatives to market capitalism are out there and the thing is, they actually align much more closely to the natural human tendencies toward reciprocity and sharing. The theories behind modern economics have left us with a burning planet and with skyrocketing inequality its time to put them to rest.

And whether economists and politicians choose to accept it or not, the days of Homo economicus are limited, because a society based off of a lie cannot go on indefinitely.

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How Economists Tricked Us Into Thinking Capitalism Works - Truthout

Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Re | COPD – Dove Medical Press

Olaf Holz,1,* David S DeLuca,2,* Stefan Roepcke,3 Thomas Illig,2 Klaus M Weinberger,46 Christian Schudt,7 Jens M Hohlfeld1,2

1Fraunhofer ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover, Germany; 2Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover, Germany; 3Department of Biomarker Development, Takeda Pharmaceuticals International GmbH, Zrich, Switzerland; 4Biocrates Life Sciences AG, Innsbruck, Austria; 5Research Group for Clinical Bioinformatics, Private University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria; 6sAnalytiCo Ltd, Belfast, Ireland; 7Department of Biochemistry, ALTANA, Konstanz, Germany

*These authors contributed equally to this work

Correspondence: Olaf HolzDepartment of Clinical Airway Research, Fraunhofer ITEM, Hannover 30625, GermanyTel +49-511-5350-8141Fax +49-511-5350-8250Email olaf.holz@item.fraunhofer.de

Purpose: There is an ongoing demand for easily accessible biomarkers that reflect the physiological and pathophysiological mechanisms of COPD. To test if an exercise challenge could help to identify clinically relevant metabolic biomarkers in COPD.Patients and Methods: We performed two constant-load exercise challenges separated by 4 weeks including smokers with COPD (n=23/19) and sex- and age-matched healthy smokers (n=23/20). Two hours after a standardized meal venous blood samples were obtained before, 5 mins after the start, at the end of submaximal exercise, and following a recovery of 20 mins. Data analysis was performed using mixed- effects model, with the metabolite level as a function of disease, time point and interaction terms and using each individuals resting level as reference.Results: Exercise duration was longer in healthy smokers but lactate levels were comparable between groups at all four time points. Glucose levels were increased in COPD. Glutamine was lower, while glutamate and arginine were higher in COPD. Branched-chain amino acids showed a stronger decline during exercise in healthy smokers. Carnitine and the acyl-carnitines C16 and C18:1 were increased in COPD. These metabolite levels and changes were reproducible in the second challenge.Conclusion: Higher serum glucose, evidence for impaired utilization of amino acids during exercise and a shift of energy metabolism to enhanced consumption of lipids could be early signs for a developing metabolic syndrome in COPD. In COPD patients, deviations of energy and nitrogen metabolism are amplified by an exercise challenge.

Keywords: targeted metabolomics, biomarker, airway inflammation

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Re | COPD - Dove Medical Press

New provost will be a "student of Yale" – Yale Alumni Magazine

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Since arriving at Yale in 1995, Scott Strobel, now the Henry Ford II Professor of Molecular Biophysics and Biochemistry, has taken on a series of administrative roles: chair of his department; vice president for West Campus planning and program development; deputy provost for teaching and learning; and vice provost for science initiatives. Now, in his highest-profile assignment yet, Strobel has been tapped by President Peter Salovey 86PhD as Yales new provostthe universitys chief academic and budgetary officersucceeding Ben Polak, who is returning to the economics faculty.

Strobel grew up around science, playing in the lab of his father, a plant pathologist at Montana State University. (I was probably doing stuff you shouldnt really let a kid do in a lab, he says.) He obtained his undergraduate degree in biochemistry from Brigham Young University, earned his doctorate at Caltech, and did postdoctoral work at the University of Colorado.

The other major influence in his early years: membership in the Bozeman Hawkers, his high schools speech and debate team. Being on that team transformed who I was and what I realized I could do, Strobel says. Its where I became comfortable in front of a classroom and in public settings.

Strobels dedication to the classroom is evidenced by the several Yale and national awards he has won for teaching and mentoring. He also oversaw the creation of Yales Poorvu Center for Teaching and Learning, accessible to everyone in Sterling Library. Its glass walls, he notes, are a reminder that teaching is a public experience that should be shared in a community of scholars.

When Strobel first moved into administration, he continued teaching his award-winning Rainforest Expedition and Laboratory course, a spring-term and summer undergraduate biology class that took Strobel and his students to the South American rain forest to analyze microorganisms they found in plant tissues. Eventually, he stopped teaching to focus on administrative responsibilities, including transforming a vast former pharmaceutical research complex into Yales West Campus, which now houses seven interdisciplinary institutes as well as the School of Nursing. (In his off hours, he has turned his wood-turning hobby into a business: he makes bowls and pens with wood salvaged from trees on the Yale campus that have been removed because of overgrowth, disease, or construction.)

When his appointment was announced in November, Strobel set a goal of meeting with every dean and speaking to as many faculty members as possible to better understand the totality of the university, pledging to be a student of Yale as well as one of its leaders. And hes not willing to give up teaching entirely: he plans to guest-lecture next spring in Donald Engelmans Biology, the World and Us, an introductory science course for nonscience majors.

Being offered a position at Yale 25 years ago was a dream come true, Strobel says. I hoped it would be an institution where my two passions of teaching and research were fully integrated. I am deeply grateful to President Salovey for the trust he is placing in me to help shape Yales future, and to determine how best to use its resources to help improve the world.

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Meet Silicon Valley’s own Willy Wonka and his chocolate-making robot – Palo Alto Online

Only in Silicon Valley does a longtime tech startup founder find a second career in a chocolate-making robot.

Nate Saal studied molecular biophysics and biochemistry at Yale University after graduating from Palo Alto High School in 1990. After returning to Palo Alto, he quickly shifted from science to the internet, founding what he says was the first web-based software updating service in 1996. He went on to start more technology companies and later worked for CNET and Cisco.

But these days, he's immersed in chocolate -- specifically, chocolate made by a countertop device that he created called CocoTerra. The sleek white device, which looks like a large, futuristic coffee maker, uses algorithms, hardware and a smartphone app to transform cocoa nibs, milk powder, cocoa powder and sugar into chocolate in about two hours.

Saal has high hopes for the machine, which has yet to be released. In the age of automation, where robots are making pizza and ramen and delivering our food, he sees CocoTerra as doing something different: using technology to deepen rather than disrupt people's connection to how their food is made.

"We're not trying to slap technology for technology's sake on top of that to abstract it away, to take creativity away," he said. "We're trying to actually create a whole new category of people who can now make chocolate."

While Saal's professional career has focused on technology, he has always filled his weekends with homegrown food experiments, like keeping bees and growing grapes and olives to make wine and olive oil from scratch. He's fascinated by the "deep science" of these activities.

Making chocolate, however, was not in his repertoire. It wasn't until he took his brother-in-law, who works in the coffee business, to a chocolate tasting several years ago, and a conversation about the similarities between the two industries got him thinking. His brother hypothesized that home coffee machines have allowed more people to understand and appreciate coffee in a way that chocolate hasn't experienced. People did make chocolate at home, but it was a lengthy process that required having several expensive appliances, he found.

"There's a bread machine, an ice cream maker and a juicer and a pasta maker and a tea brewer and a coffee maker -- every major food category has a home appliance. What I discovered very quickly was there is no such thing (for chocolate)," Saal said.

He educated himself by going to chocolate-making classes, including a boot camp at Madre Chocolate in Hawaii. Back in Palo Alto, he and a team got to work designing a device that could combine all steps in the chocolate-making process -- grinding, refining, conching, tempering and molding -- in one machine. It typically grinds the single-origin cocoa nibs for about half an hour, using stainless steel balls, then refines the cocoa butter, sugar and milk powder. Conching is the "slow manipulation or agitation of chocolate at elevated temperatures to help drive off some undesired flavors," said Chief Operating Officer Karen Alter. Named for conch shell-shaped equipment, this is part of the process is often on display during chocolate factory tours, she said, with large vats that have paddles slowly moving liquid chocolate.

The next step, tempering, involves cooling the ingredients to a specific temperature that will create a specific structure of seed crystal in the cocoa butter molecules, Saal enthusiastically explained. The crystals solidify, creating shiny, hard chocolate. A patented centrifuge inside the machine cools and spins the chocolate to remove bubbles.

The final result is a ring-shaped, half-pound mold of chocolate, rather than the traditional rectangular bar.

On the back end, technology allows a level of customization that CocoTerra's creators hope will make the device as appealing for experts as for novices. A cloud-based recipe system, accessible online or via an app, guides you from start to finish in a recipe. People can either default to CocoTerra's recipes, such as 62% dark chocolate or milk chocolate with almonds, or customize them, from level of sweetness and creaminess, to added flavors and ingredients, to the tempering temperature. People can easily control for allergies or dietary restrictions.

CocoTerra will sell the base ingredients directly to customers, focusing on fair trade, ethically grown nibs, or people can use their own. Those who are advanced enough to roast and shell their own cacao beans could still do that, put them into the machine and then create their own recipes.

Producing quality chocolate in two hours is "jaw-dropping" to many in the chocolate industry, Saal said.

"I thought they were totally crazy when I first talked to them on the phone," John Scharffenberger told CNBC. Scharffenberger, who co-founded Scharffen Berger in San Francisco in 1997 before small batch, artisan chocolate was a thing, is now a CocoTerra investor and calls it "a natural extension of the craft chocolate movement."

The company won't disclose a price for the machine, which they claim is the world's first tabletop chocolate maker. CocoTerra has raised more than $2 million in investments and is now focused on a larger round to fund the release of the device.

"This is about the evolution of technology to make chocolate. But it's also making it accessible," Saal said. "We're bringing that to people by using smart mechanical engineering and software to make it accessible so that you can actually now focus on things like the flavor and recipe and the look and the design and the craft of it."

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Meet Silicon Valley's own Willy Wonka and his chocolate-making robot - Palo Alto Online

Study focuses on key structure of C. difficle bacteria that could lead to future treatments – Business Standard

You are here Home Video Gallery Study focuses on key structure of C. difficle bacteria that could lead to future treatments Study focuses on key structure of C. difficle bacteria that could lead to future treatments

New Delhi, Jan 06 (ANI): Researchers have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The finding of the study was published in the journal of Proceedings of the National Academy of Sciences.

Researchers at the University of Maryland School of Medicine and their colleagues used cryo-electron microscopy, X-ray crystallography and other biophysical methods to identify the microscopic structures of the bacteria. The researchers mapped out the delivery and binding components of the toxin, which could pave the way for new drugs to neutralize it.

"We identified two structures that help explain the molecular underpinnings of C. difficile toxicity," said study co-author David Weber, Ph.D., a Professor of Biochemistry and Molecular Biology and Director of the Center for Biomolecular Therapeutics at UMSOM.

"These structures will be important for targeting th

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Study focuses on key structure of C. difficle bacteria that could lead to future treatments - Business Standard

Seven to receive 2020 Alumni Awards – News – Illinois State University News

David DeMarini 72, M.S. 74, Ph.D. 80, accepts the 2019 Distinguished Alumni Award.

Each yearIllinois State Universitys Alumni Association recognizes alumni for their outstanding contributions to their fields, their impact on society, and their passion for Illinois State through the Alumni Awards program. This year seven individuals will be honored at the Annual Awards Dinner:

Distinguished Alumni AwardJay D. Bergman 70CEO and chairman, Petco Petroleum Corp.Major/College: Business administration, College of Business

Alumni Achievement AwardDaniel Wagner 89, M.S. 94Senior vice president of government relations, Inland Real Estate GroupMajor/College: Political science, College of Arts and Science

Senator John W. Maitland Jr. Commitment to Education AwardDamian K. GregoryFounder and executive director, Gridiron Group

E. Burton Mercier Alumni Service AwardBeverly Grimes 60Retired nurseMajor/College: Nursing, Mennonite College of Nursing

Outstanding Young Alumni AwardPaul DeJong 15Shortstop, St. Louis CardinalsMajor/College: Biochemistry, College of Arts and Science

Jenna Goldsmith 08, M.S. 10Instructor of Writing, Oregon State University-CascadesMajor/College: English, College of Arts and Science

Griffin Hammond 07, M.S. 09Documentary Filmmaker, Recount MediaMajor/College: Television/Communication, College of Arts and Science

Nominations are also being sought for the 2021 Alumni Awards. The deadline to submit is May 31, 2020.

A quick summary how to recognize outstanding alumni.

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Seven to receive 2020 Alumni Awards - News - Illinois State University News