Researchers at U of T, Sinai Health working on blood test to screen thousands for COVID-19 immunity – News@UofT

A team of researchers at Sinai Health Systemand the University of Toronto is in the early stages of developing a blood test that can identify who is immune to COVID-19 on a mass scale.

The test is an adaptation of an ELISA assay (enzyme-linked immunosorbent assay)and has the potential to enable hospitals and other institutions to screen up to 10,000 samples at once, allowing entire workforces to be tested efficiently.

The blood-based test, whichthe team hopes to test on volunteers within the next two weeks, does not directly detect the live virus and is not intended to replace current tests for infection.

Anne-Claude Gingras, project co-lead, said the test works by detecting antibodies in the immune system of infected patients. Those antibodies persist in blood even after the virus has been completely eliminated.

The entire city has come together to make this possible, said Gingras, a senior investigator at Sinai Healths Lunenfeld-Tanenbaum Research Institute (LTRI) and a professor of molecular genetics at U of T. This test is being developed with the goal of monitoring the percentage of the population that has been infected and to help in identifying those individuals that may have protective immunity.

The project is a collaboration between Gingras and Jeff Wrana, also a senior investigator at LTRI and a professor of molecular genetics at U of T, and other researchers from the Faculty of Medicine.

The team includes James Rini, a professor of biochemistry and molecular genetics who was key to producing proteins for the assay, and Professors Jennifer Gommerman and Mario Ostrowski from the department of immunology, who helped supply samples from pre-pandemic subjects as well as patients infected early in the pandemic who have since recovered.

The new ELISA test can provide valuable information about the spread of SARS-CoV-2 in Canada, said Karen Maxwell, an assistant professor of biochemistry who is helping to co-ordinate COVID-19 research at U of T.

This test will allow us to track the true spread and magnitude of the disease, Maxwell said. Determining who has been infected and has antibodies will be important information for making decisions about how and when we return to our normal activities.

The test will make use of the robotics platform at LTRI. Jim Woodgett, director of research at LTRI and a professor of medical biophysics at U of T, said such advances are possible thanks to close collaboration between scientists across institutions.

Sinai Health and the University of Toronto are ideally positioned to develop this critically important antibody-based test, Woodgett said. This research group is eager to contribute in any way possible to help Canada overcome this historic public health challenge.

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Researchers at U of T, Sinai Health working on blood test to screen thousands for COVID-19 immunity - News@UofT

‘Behind the Blue Special Edition’: Rebecca Dutch on UK’s Efforts to Treat, Understand and Eradicate COVID-19 – UKNow

LEXINGTON, Ky. (April 7, 2020) Rebecca Dutch has been at the University of Kentucky for nearly 20 years. She is considered a leader in the field of virology the study of viruses and now serves as chair of UKs Department of Molecular andCellular Biochemistry.

But her newest field of exploration is unlike anything she has done in her storied career.

She is helping lead researchers and faculty from multiple disciplines across the University of Kentucky as part of the global effort to treat, understand and eradicate COVID-19. The COVID-19 Unified Research Experts (CURE) Alliance team, a new workgroup within UKs College of Medicine, is bringing together UK experts from across the campus to focus on advising COVID-19 patient care and clinical trials based on emerging research and potential treatment options.

College of Medicine Dean Robert DiPaola recently announced the creation of CURE, which the college is funding with additional support from UKs Vice President for Research Lisa Cassis.

Over the next weeks, we will assess emerging studies to guide the College of Medicines clinical enterprise to provide the best COVID-19 patient care available, said Dutch, who is CURE leader. Our goal, in the long term, is to identify the best options for patient participation in ongoing clinical trials, as well as clinical trials we can develop right here at UK.

Dutch says the team, which is now meeting multiple times a week via Zoom, is also identifying potential COVID-19 research collaborations among UK experts. Several CURE team members have expertise directly related to COVID-19.

In this special edition of "Behind the Blue," Dutch discusses her efforts and those of others across the campus to find treatments for COVID-19 as well as why the virus has spread the way it has and how we can all better protect ourselves and others.

Read more about CURE here: http://uknow.uky.edu/research/university-kentucky-researchers-unite-fight-covid-19.

"Behind the Blue" is available on iTunes, Google Play, Stitcher and Spotify. Become a subscriber to receive new episodes of Behind the Blue each week. UKs latest medical breakthroughs, research, artists and writers will be featured, along with the most important news impacting the university.

For questions or comments about this or any other episode of "Behind the Blue,"emailBehindTheBlue@uky.eduor tweet your question with #BehindTheBlue. Transcripts for this or other episodes of "Behind the Blue" can be downloaded from the shows blog page.You can watch a video version of this podcast here.

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'Behind the Blue Special Edition': Rebecca Dutch on UK's Efforts to Treat, Understand and Eradicate COVID-19 - UKNow

The Science Behind The BCG Vaccine – Newstalk 106-108 fm

Luke ONeill, Professor of Biochemistry Trinity College,

We look at the science behind the BCG vaccine, with Prof Luke O'Neil Professor of Biochemistry at Trinity College, MihaiNeteaOIfeInfectious DiseaseSpecialist and Prof of ExperimentalInternal Medicine andPaul Hegarty, Consultant Urologist, Mater Private Hospital & Mater Misericordiae University Hospital.

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The Science Behind The BCG Vaccine - Newstalk 106-108 fm

‘We will get through this," says Nation’s Doctor: Dr. Jerome Adams – BlackEngineer.com

No doubt about it, COVID is on the mind of the United States Surgeon General. Speaking on television Tuesday, Dr. Jerome Adams indicated there were green shoots of hope. The mitigation is working, Dr. Adams said. It tells us social distancing, practicing good hygiene, and the 30-day guidelines for America are effective and will help us get to the other side of this unfortunate tragedy.

As the country rallies against the coronavirus disease, Dr. Adams said the government will do two million COVID-19 testings this week. The surgeon general added that by the end of the month there will be diagnostic and surveillance testing across the country. The industryis also on board with antibody testing.

According to the medical community, there are tests that check the blood for antibodies providing confirmation of infection and possible protection. And then there are diagnostic tests that confirm whether someone has an active infection, which could be useful to form better estimates of the scale of infection and the death rate of the virus.

Speaking on the death rate of blacks and ethnic minorities, the surgeon general said the CDC is tracking the disease demographically.

The surgeon general said whether we are white, black, brown or yellow, wearing a face mask will help protect ourselves and each other.

Dr. Jerome M. Adams was sworn in as Surgeon General by Vice President Mike Pence at the Office of the Vice President in Washington D.C.

As the No. 1 doctor in the United States, Dr. Adams gives Americans the best scientific information available on how to improve their health and reduce the risk of illness and injury.

Since he graduated in 2002 from the Indiana School of Medicine, which educates future physicians and conducts advanced medical research throughout Indiana, Dr. Adams has put himself on the path to success.

Dr. Jerome Adams distinguished himself as an anesthesiologist at Eskenazi Hospital in Indianapolis, which serves our most vulnerable citizens, and as a clinical associate professor of anesthesiology at Indiana University, Vice President Pence said on his appointment.

As Indiana health commissioner from 2014 to 2017, Adams dealt with infant mortality in high-risk areas and the opioid-fueled-HIV/AIDS epidemic in rural areas.

We had an extraordinarily diverse cabinet when he (Pence) was governor, and he took a chance on this young, African-American guy from the East Coast to be his health commissioner, Adams said at his swearing-in ceremony as the top doctor.

Dr. Adams has a master of public health degree from the University of California at Berkeley, a medical degree from Indiana University School of Medicine, and a bachelors degree in biochemistry and psychology from the University of Maryland, Baltimore County.

How a medical doctor was born

Jerome Adamss father, who is a U.S. military veteran and retired tech Maryland teacher, said that one experience that might have left a lasting impression on his son was going to hospital twenty-two times in one year because of his childhood asthma attacks.

Another experience that served as an inspiration was the Ebola virus outbreak in Zimbabwe. Adams did research in the southern African country as a biochemistry student attached to the Meyerhoff Scholars Program at the University of Maryland, Baltimore County (UMBC).

A Distinguished Meyerhoff Scholar

According to UMBC, the Meyerhoff program has graduated over 900 students since 1993. To date, alumni from the program have earned 198 Ph. D.s, 239 Masters degrees, as well as 107 M.D. degrees. Some work as scientists, researchers, teachers, and physicians.

As surgeon general, Dr. Adams is a commissioned officer in the Public Health Service Commissioned Corps and by law holds the rank of vice admiral (three stars). The Commissioned Corps of the United States Public Health Service Corps is one of the seven Uniformed Services.

Both the position of Surgeon General, and the United States Public Health Corps that the Surgeon General leads, are an extremely important component of our national health education and response, Dr. Adams said at his nomination hearing chaired by the Senate Health, Education, Labor, and Pensions Committee this August.

Prevention, wellness, and health promotion

The Public Health Service Commissioned Corps has approximately 6,500 uniformed health officers who serve in 600 locations around the world to promote, protect and advance the health and safety of America and the world.

Whether we are facing infectious diseases like Ebola and Zika, or natural disasters like earthquakes and Hurricane Katrina, or human-caused tragedies like 9/11 and the opioid epidemic, our country and our world need this ready to respond army of health experts, Dr. Adams said.

He also added that while many people call the surgeon general Americas top doctor one person cant be all things to health and doesnt give proper consideration to the vital role partnerships play in the success of this position, Dr. Adams said.

The position of Surgeon General carries with it tremendous power to convene supporters (as well as detractors), and to facilitate health and wellness discussions, Adams said. The power of the position comes from the even wider array of health crusaders that can be mobilized from a multitude of sectors across our country if the platform is used properly.

Dr. Adams has served in leadership positions at a number of professional organizations, including the American Medical Association, the Indiana State Medical Association and the Indiana Society of Anesthesiologists. He is the immediate past Chair of the Professional Diversity Committee for the American Society of Anesthesiologists

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'We will get through this," says Nation's Doctor: Dr. Jerome Adams - BlackEngineer.com

2020 UWMadison Distinguished Teaching Awards – University of Wisconsin-Madison

Thirteen faculty members have been chosen to receive this yearsDistinguished Teaching Awards, an honor that annually recognizes some of UWMadisons finest educators. The following testimonials were given, and photographs made, before virtual teaching was instituted in response to COVID-19 but whatever form instruction might take, this group ranks among the universitys best. While the ceremony originally scheduled for April 7 has been postponed, we honor the winners here, and commend all who are teaching in these challenging times.

Photographs byJeff MillerandBryce Richter

Emil Steiger Teaching Award

PaulBlockAssociate professor of civil and environmental engineering

Paul Block teaches graduate students a Hydroclimatology for Water Resources Management class in Engineering Hall. Photo: Jeff Miller

Block has taught each semester since beginning at UWMadison in 2013 at both the graduate and undergraduate level. He creates an intellectually stimulating classroom environment by combining demonstrations, experiential learning, reinforcement and critical thinking in an interactive setting. Block has modernized the content of several courses and significantly upgraded lab facilities, modules and the number of experiments students do. Fluid Mechanics is widely regarded as one of the more difficult engineering courses, but Block uses demonstrations, experiments and visuals to make it engaging and enjoyable. His research and applications connecting climate prediction and water resources systems management have involved international efforts and collaborations, ranging from Ethiopia to Peru and Chile.

Class of 1955 Teaching Excellence Award

William BrocklissAssociate professor, Classical & Ancient Near Eastern Studies

William Brockliss is pictured with artwork titled Sarcophagus with the Allegory of the Four Seasons in the Roman and Greek collection at the Chazen Museum of Art. Photo: Jeff Miller

Brockliss has a gift for engaging students through discussions, activities and presentations, even in high-enrollment courses like his popular Ancient Greek and Roman Monsters course. He has given presentations on classics and the Latin language to students in elementary and high school, acted as a liaison with Latin teachers from Wisconsin high schools, organized three visit days for high-school students on the UW campus, and taught classes for the Odyssey Project, which allows low-income adults to earn college credit. Brockliss has served as a mentor to students with an interest in teaching high school Latin, with three going on to be certified to teach Latin and now employed in Wisconsin high schools.

Chancellors Distinguished Teaching Award

SamuelButcherProfessor of biochemistry

Samuel Butcher is pictured in his office at the Biochemistry Labs. Photo: Jeff Miller

Butcher has been teaching Introduction to Biochemistry for almost two decades, with enrollment growing from 200 students per semester to more than 600. He has been instrumental in reshaping the course with the goal of teaching students to think like a scientist. Theyre focused on learning concepts rather than memorizing facts. Butcher is also committed to accessibility and led an initiative to add more sections of Biochem 501, including courses in the summer and online to increase access. He has been a leader in using technology to make the course material more accessible for all students, regardless of disability or learning style.

Chancellors Teaching Innovation Award

ShuchiChawlaProfessor of computer science

Shuchi Chawla teaches students an Introduction to Algorithms class in Noland Hall. Photo: Jeff Miller

Chawla has risen to the challenge in teaching Computer Science 577: Introduction to Algorithms. When she began teaching the course in 2006, 30 students were enrolled. Today, there are more than 300. To ensure that todays students receive the same high-quality experience as their predecessors, she has restructured the pace of the course, held frequent office hours, and brought in peer mentors (undergrads who have recently taken the course) so that students who are struggling have a variety of resources available when they need help. The peer mentor system has been so successful it has been adopted for other Computer Science courses.

William H. Kiekhofer Teaching Award

Kathleen CulverAssociate professor of journalism and mass communication

Kathleen Culver teaches a Journalism 563: Law of Mass Communication class in Helen C. White Hall. Photo: Jeff Miller

As the driving force behind Journalism 202: Mass Media Practices, Culver is responsible for giving students a solid foundation for success in the rapidly changing media landscape. Her effectiveness is evident in the words of the many students she has guided and mentored, both in and out of the classroom. Culver has trained media educators from across the country at the Poynter Institute for Media Studies, and as director of the Center for Journalism Ethics, she serves as a source for reporters on questions of journalism ethics, digital innovations in journalism, and other contemporary issues.

Chancellors Inclusive Excellence Award

RamziFawazAssociate professor of English

Ramzi Fawaz is pictured at Stanford University, where he is currently on leave as a 2019-2020 faculty fellow. By Steve Castillo, courtesy of Stanford Humanities Center

Fawaz has added many innovative courses to the English departments offerings, with titles such as Queer about Comics, Gay is Good: Queer Visions of Freedom Since the 1970s and America in the 1990s. In an open, welcoming setting that encourages students to share their thoughts and feelings about the course material, he challenges students to step out of their comfort zones and examine their views of the world. Fawazs influence on teaching extends well beyond the university. Among his many outreach activities, he frequently participates in interviews and panel discussions on teaching and has written a widely read article on trigger warnings in the classroom.

Chancellors Distinguished Teaching Award

ChristineGarloughProfessor of gender and womens studies

Christine Garlough talks with students during a Gender and Womens Studies 449 course in Chamberlin Hall. Photo: Bryce Richter

Garlough believes classrooms should address real-world issues with rigor and compassion, guiding students to pursue knowledge and develop their own voices. She inspires critical thinking and self-reflection in a supportive learning environment. Her approach mixes lecture, discussion and small group participation. Students in large lectures can be disinclined to connect with others in a sea of strangers, but Garlough regularly creates opportunities for dialogue and engaged listening. Students eagerly engage with others every class period and even change seats over the course of the semester so they can benefit from discussion with a variety of classmates holding different perspectives.

Chancellors Distinguished Teaching Award

EricaHalversonProfessor of curriculum and instruction

Erica Halverson talks with students at Thoreau Elementary School in Madison during a Whoopensocker outreach program event. Photo: Bryce Richter

Halversons work focuses on teaching and learning in and through the arts. From First-Year Interest Groups to graduate-level courses, she is known for challenging her students to understand themselves and their world differently. She designed and teaches Arts Integration for Teaching and Learning, a unique course that engages future elementary school teachers in understanding and using various art forms in their teaching. The students learn to create art that represents their experiences and to think about how they might bring the arts into their future classrooms not only for the arts own sake, but also in support of core concepts like reading and math.

Excellence in Community-Based Learning Teaching Award

AndreaHicksAssistant professor of civil and environmental engineering

Andrea Hicks is pictured in her office in Engineering Hall. Photo: Bryce Richter

Hicks used a $5,000 grant from the Morgridge Center for Public Service to turn her Environmental Sustainability Engineering course into a community-based learning course. She works with the UniverCity Year program, which connects the UW with Wisconsin communities, to find class projects. Her students then work on problems identified by counties, villages and school districts. Students evaluate the problem and potential solutions using the three paradigms of sustainability: environment, economy and society. Community partners use the students work to advance projects in areas such as renewable energy and wastewater treatment. Students love the opportunity to take what theyve learned in the classroom and apply it to real-life problems.

Chancellors Distinguished Teaching Award

IrenaKnezevicProfessor of electrical and computer engineering

Irena Knezevic talks with a graduate student during a progress check-in meeting. Photo: Bryce Richter

ECE 235: Introduction to Solid State Electronics is a required course with a large enrollment and difficult subject matter. But 10 years ago, Knezevic reimagined how the fundamentals of quantum mechanics could be introduced to undergraduate engineering learners and revamped the course. She developed a successful approach thats been adopted by everyone who teaches it. She began redesigning the course before she had been granted tenure a time when junior faculty typically devote most of their time to research. Her reward was the knowledge that students would more easily master difficult material and would approach the course with enthusiasm rather than dread.

Chancellors Inclusive Excellence Award

LoriLopezAssociate professor of communication arts

Lori Lopez talks with students during a Communication Arts 250 course in the Educational Sciences Building. Photo: Bryce Richter

In teaching everything from large introductory courses to small graduate seminars, Lopez has earned high marks and glowing comments from students for her approach to controversial topics such as racism. As the creator and chair of her departments Diversity and Equity Committee, she has added mini trainings to monthly department meetings, on topics such as trans-inclusive pedagogy, universal design, diversifying the syllabus, and diversity accommodations. Lopez is also committed to creating opportunities for learning outside of the classroom and created Madisons Asian American Media Spotlight, a film festival that invites filmmakers from across the country to screen their films on campus and engage in discussions with students.

Chancellors Distinguished Teaching Award

JenniferRatner-RosenhagenProfessor of history

Jennifer Ratner-Rosenhagen talks with audience members during a public lecture in the Elvehjem Building. Photo: Bryce Richter

Ratner-Rosenhagen teaches U.S. intellectual history a topic she acknowledges might seem forbidding, arcane and dull to undergrads. But she brings it to life and gives her students the confidence to believe that they can do important intellectual work. Her innovative undergraduate courses build on students interests and guide them in thinking about how key ideas in U.S. intellectual history relate to their own lives. In her course titled A History of Your Parents Generation: 1970s-90s, students interview their parents about their memories of that time. Outside the classroom, she founded the Intellectual History Group grad students and faculty who meet to discuss books, articles and dissertation chapters.

Van Hise Outreach Teaching Award

KateVieiraAssociate professor of curriculum and instruction

Kate Vieira talks with students during a Curriculum and Instruction 596 class session in the Teacher Education Building. Photo: Bryce Richter

Vieiras work focuses on issues of literacy among everyday people, especially those at the margins of society. She explores literacy and writing as a means of social change. Her outreach work has taken her to Colombia, where she has worked with community members using writing to help people build peace after the violence of a decades-long civil war. Locally, she has forged connections between South American educators and the Madison community. Two of her collaborators from Colombia visited last May to co-lead workshops at East and West high schools, meet with local Latinx writers, and share pedagogical practices with representatives of the Greater Madison Writing Project.

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2020 UWMadison Distinguished Teaching Awards - University of Wisconsin-Madison

The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Pr | DMSO – Dove Medical Press

Andrs Garca-Snchez, Jorge Ivn Gmez-Nava, Elodia Nataly Daz-de la Cruz, Ernesto Germn Cardona-Muoz, Itzel Nayar Becerra-Alvarado, Javier Alejandro Aceves-Aceves, Esther Nrida Snchez-Rodrguez, Alejandra Guillermina Miranda-Daz

Department of Physiology, University Health Sciences Centre, University of Guadalajara, Guadalajara, Jalisco, Mexico

Correspondence: Alejandra Guillermina Miranda-DazDepartment of Physiology, University Health Sciences Centre, University of Guadalajara, Guadalajara, Jalisco, MexicoEmail kindalex1@outlook.com

Purpose: The increase of visceral abdominal fat (VAF) and oxidative stress (OS) are independent predictors for cardiovascular risk. This study aimed to determine the association of VAF with proinflammatory cytokines, oxidants, antioxidants, and oxidative damage to DNA in subjects with normalweight, overweight, and obesity.PatientsandMethods: A cross-sectional study that included 21 men and 71 women whoattended for a medical check-up was conducted. Dual-energy X-ray absorptiometry (DXA) was used to measure the VAF volume. ELISA and colorimetric techniques were used for chemical analysis.Results: Low activity of superoxide dismutase (SOD) was found in overweight and obese subjects compared to the normalweight group (p=0.005). In contrast, the activity of glutathione peroxidase (GPx) was higher in the overweight and obesity groups compared to the normalweight subjects (p=0.017). The total antioxidant capacity (TAC) was alsoincreased in the overweight group compared to the normalweight group (p=0.04). According to the volume of VAF, the levels of tumor necrosis factor alfa and interleukin 6 showed no differences between subjects with normal and high VAF. Subjects with high VAF show higher levels of 8-isoprostans compared to normal VAF group (p=0.039). Less concentration of 8-oxoguanine-DNA-N-glycosylase-1 (hOGG1) was found in the high VAF group (p=0.032) compared to thenormal VAF subjects. VAF was positively correlated with lipoperoxides (LPO) (r=0.27, p< 0.05) and 8-isoprostanes (r=0.25, p< 0.05). We also found correlations between oxidative stress markers and anthropometric ratios for intra-abdominal fat. The waist-hip ratio was positively correlated with LPO (r=0.30, p< 0.05) and TAC (r=0.24, p< 0.05).Conclusion: These findings suggest that the predominantly oxidative damage associated with VAF in overweight or obesity is lipoperoxidation and oxidative DNA damage. Alterations in endogenous antioxidant defenses may not be linked to the amount of VAF.

Keywords: oxidative stress, oxidative DNA damage, antioxidant enzymes, Lunar iDXA, visceral fat cutoff score

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Pr | DMSO - Dove Medical Press

Growing from there to here – Good Fruit Grower

In its natural habitat, a sweet cherry tree can grow up to 135 feet, much higher than an apple trees 40 feet, or even a pear trees 65 feet. Combine that height with small, delicate fruit that needs to be picked by the stem, and its safe to say the cherry tree poses some unique management challenges.

Its a forest tree, said Greg Lang, a professor of horticulture at Michigan State University. Lang spoke during the International Fruit Tree Associations 2020 conference in Grand Rapids, Michigan. It evolved over centuries to survive in forests.

But over the last few decades, researchers, nurserymen and growers have manipulated the giant forest trees physiology into the small yet productive tree we see in modern, high-density orchards today. Cherry trees, it turns out, can grow into unusual shapes. Lang focused especially on the UFO system upright fruiting offshoots named by Matt Whiting, a Washington State University professor.

Lang expects the UFO system to be common a decade from now. Its yields can be equal to or greater than other systems, crop load management and fruit quality are more uniform, hand harvest is more efficient, and the structure is more amenable to precision tools and technology.

But how did we get from there to here from the forest giant to the UFO? Lang started by explaining how a seedling survives.

A cherry seedlings top priority is to grow a vertical leader that can capture as much light as possible in a crowded forest. To achieve apical dominance, all of the trees energy and growth goes toward its top in the first year, he said.

Vigor is always greatest in the tops of trees, Lang said. Even when they are 35 or more years old.

Beginning in the second year, the leader keeps growing, but the tree also initiates upright primary lateral growth just below it (so if the leader dies, one of the laterals can take over). Lower secondary branches grow horizontally beneath the primary laterals, to capture light the leader isnt getting and to shade out forest competitors, he said.

As the tree ages, its extreme vigor is dispersed into the laterals. In order to capture new light, its large leaves arise as far away from the previously formed leaves as possible.

(The cherry tree) still thinks its in the forest and (it is) trying to grow up and capture light, Lang said. Thats what were trying to manage throughout the life of the orchard.

For a long time, commercial growers had to focus on managing a freestanding cherry trees incredible vigor keeping it at a reasonable size rather than managing its crop load. Things changed in the 1990s, however, when dwarfing rootstocks became available.

The question we started wrestling with when we got dwarfing rootstocks for sweet cherries was: How can we get toward precise crop load management of a cherry tree now that we have a smaller tree than that forest tree? Lang said.

He turned to grapevines for inspiration.

I said, Lets grow a cherry tree like a grape, where it is easy to prune to a specific number of spurs and buds that lead to a specific spacing and quantity of shoots and fruit clusters.

With this in mind, in 1999, Lang, who was with WSU at the time, developed a planar cherry tree canopy structure to emulate the two cordons and vertical shoot position training of wine grapes. WSUs Whiting further developed the concept with UFO a system that utilizes the natural growth habit the cherry tree evolved over centuries to most efficiently capture sunlight, Lang said.

UFO takes advantage of the trees natural upright growth by establishing multiple vertical fruiting units in a narrowly aligned row arising from a primary trunk thats trained horizontally. The number of vertical fruiting units is varied to diffuse vigor in proportion to the overall vigor of the rootstock-scion-soil-climate matrix yielding the only training system that can be adapted to any rootstock. The system also takes advantage of the leaves natural arrangement forming on the vertical shoot as far away, horizontally, from previous leaves as possible to minimize shading and maximize light penetration, Lang said.

by Matt Milkovich

Related:Precision vision on 2020 IFTA Michigan tourStill no answer for bitter pitBattle of the cherry architecturesGrowers gain UFO experience

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Growing from there to here - Good Fruit Grower

Is there a best time to train? A sports scientist investigates – Cycling Weekly

Lets face it, no matter what we tell our friends, cycling comes quite far down the priority list when drawing up the days to-do list. We ride when we can fit it in, rather than at the best possible time for making fitness gains.

As amateur riders, our family, friends, work and sleep you choose the order of priority put the squeeze on our windows of opportunity for getting in quality saddle-time. The question is, does it matter what time you train?

The evidence suggests that, yes, it does. For various reasons, our bodies may have a preference that affects the training response. This feature will investigate the physical and mental effects of riding at different times of day. Should you schedule different types of session at particular times? And are there certain times of day you should actively avoid?

Often, we have to resort to training at the only time available to us. Mercifully, now that were emerging from the dark, wet winter, well soon have a few extra hours of daylight to play with at each end of the day. What does the science tell us about the best time to choose? Chronobiology is the study of lifes rhythms: heart rate, body temperature, and a variety of hormonal responses that follow the daily (or circadian) pattern. These rhythms are programmed genetically as well as being influenced by our environment and activity. Exercise performance can be dramatically affected up to 15 per cent by variations in these rhythms.

Dr Brendan Gabriel, from the University of Edinburgh, studies circadian biology in clinical conditions and sport.

Rhythmic changes in core/muscle temperature and hormonal signalling particularly adrenaline can affect exercise performance, including oxygen uptake and mechanical power, explains Gabriel. The hypothalamus, our brains regulatory control centre, is very reactive to daylight and receives this signal mainly from the eyes the reason why light is such an important trigger.

>>> Zwift is trialling a new clubs feature, including events and leaderboards

This reactivity to light is why humans are diurnal active during the day, asleep at night. But we are not all the same. There are differences between individuals sleep/wake behaviours and our preferred pattern is known as our chronotype. Owls prefer to rise late and retire late (e.g. get up at 10am and go to bed at midnight), while at the other extreme, larks favour an early start and early bedtime (e.g. awake by 7am, asleep by 9pm). Most of us fit somewhere in between, with our physiological rhythms set accordingly.

You probably know straight away which side of the chronotype fence you sit on, but if you want to make sure, check out a Morningness-Eveningness Questionnaire. Depending on where you fit on this spectrum, there are implications for which times of the day best suit you for training, bearing in mind that circadian rhythms can be affected by activities including exercise and meal times.

Regardless of your chronotype, riding before work probably feels harder than at mid-morning, owing to sleep inertia the drowsiness that gradually dissipates after waking. However, if early morning is your only option, there are some useful tips for shifting or resetting your rhythm so as to get through the first few kilometres and out of the circadian trough.

The simplest solution is often the best: get up earlier. Dragging yourself out of bed kick-starts the myriad physiological processes, which during the early hours of the morning were at their lowest point. Consistently rising a little earlier could have a lasting effect on your circadian rhythms with an important footnote: make sure you balance this with a suitably earlier bedtime, and stick to it. Relapsing over a weekend off or a holiday will set you back to square one.

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Once youre awake and moving around, continued exposure to light is a major stimulus. If drawing back the curtains reveals only more darkness, artificial light is an effective substitute, and there is some evidence that daylight bulbs are effective. Eating also has a pronounced effect on your daily highs and lows, so have breakfast in good time, at least an hour before heading out. This not only provides you with the energy you need, but helps to wake you up too. Even so, you are unlikely to snatch a KOM or PB first thing in the morning.

Illustration: David Lyttleton

The answer here is to adjust your expectations to suit the time of day. When riding at a time that is not optimal for your physiology, pay less attention to the external outputs such as speed and power, and rely instead on internal parameters such as heart rate and perceived exertion. If you must squeeze in a Zone 2 training ride before breakfast, ride at the speed that elicits a Zone 2 physiological response rather than the wattage or speed that would usually equate to Zone 2 later in the day.

Keep records and have morning and evening ranges these will allow you to monitor shifts in your chronotype, should they occur. The evidence suggests that diurnal fluctuations have a greater effect on strength and power events than on endurance exercise, so short intense efforts may feel harder in the morning than in the evening. If this is true for you, avoid high-intensity interval sessions or strength training early in the day.

Human physiological systems appear to become more efficient as the day progresses. Annoyingly, we are probably best ready to ride during the middle part of the day, when most of us are at work. Does this mean that riding after work is seriously disadvantaged? Thankfully not. There is evidence to suggest that the psychological effects of work add another dimension to our ability to apply effort later in the day.

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Professor Samuele Marcora, of the University of Bologna, has published several papers investigating the effects of mentally fatiguing tasks on sports performance. This research has established that mental fatigue can have a debilitating effect on exercise performance. When the mentally fatiguing stimulus is removed, athletes perceive subsequent exercise as being easier and thus perform better. A day at work may have a similar effect on your training session. Have you felt a lack of motivation while training after a stressful day? Pushing through might make you stronger.

A further disadvantage when training late in the day is its effect on subsequent sleep. As we have learnt, training can disrupt our circadian rhythm, meaning we may not be ready for bed until later than normal (particularly if youve taken a caffeine supplement). Eating later adds to the potential for sleep trouble. If you cant drop off, avoid lying awake for hours getting frustrated; instead, read or get up and do something different (avoiding screens) until you feel weary.

Marcora advises that the best time to train, from a psycho-biological perspective, is late morning or lunchtime.

Mentally, we are fresher, and the perception of effort is lower enabling us to push harder. Most people are understandably mentally fatigued in the evening after a day at work, so if this is your only option, taking caffeine prior to your workout will help reduce the perceived effort.

As we have seen, there are pros and cons to riding at either end of the day. This poses an intriguing question: is there an edge to be gained by facing down the fatigue and training at a time when you are less primed or motivated? Marcora believes there may be. If the aim of a session is to develop brain endurance that is, mental resilience for long or intense exercise the professor postulates that training in the evening might increase the perceived effort of a session and subsequently lead to improved endurance performance.

Physiologically, there appears to be little evidence to suggest that training early (or late) improves subsequent performance during optimal hours.

But it may help to train at the time of day you intend to race. According to Dr Gabriel, you should regularly train at the time you intend to race as part of your preparation so as to get your physiological rhythms primed and adapted. For example, if your long sportive has an early morning start time, make sure you head out early on some of your training rides in the weeks before.

With cycling holidays becoming ever more popular, another situation where managing your circadian variation becomes crucial is around travel. When flying abroad, you should aim to adjust to the new time zone (no matter how small) as quickly as possible by getting into your new normal daily routine. This has long been a concern for elite athletes who travel the world to train and compete. The primary cause of jet lag is disruptions to the sleep-wake cycle. To overcome this problem, Team GB athletes travelling to the Tokyo Olympics in August will be advised to allow one day per time zone crossed to fully adjust in time to compete.

For shorter trips, when the time difference is only an hour or two, you could tweak your routine in the few days before you leave to match the destination time zone just make sure to turn up to the airport on time!While your daily biological rhythms are largely pre-programmed, it is worth being strategic about the time of day you train. Sometimes training while mentally tired may elicit an extra adaptation, provided you dont overdo it and risk falling into a state of burn-out.

Whenever possible, train at the time of day when you feel most energised. If youre forced to train early or late in the day, remember that extending your waking hours will take its toll if you do not make adjustments to compensate for the reduction in sleep. Training counts for nothing unless you allow your body to recover, repair and adapt. The benefits of sleep, particularly in athletes, are well reported and far greater than any potential gains induced through a tweak in circadian rhythms, so whatever you do, dont go burning the candle at both ends.

Being ready to compete is key to good performance. Early start times can be commonplace in amateur cyclo-cross or time trial competitions, so what can you do to maximise your mental and physical alertness in preparation?

Wake time

The earlier you rise before your start time, the better within reason. T-minus two hours is a good starting point, but experiment and find out what works for you, especially when travelling is involved.

Light

If you need to be up before the sun rises, a useful compromise can be a light therapy product such as a Lumie light (lumie.com), which simulates natural light more effective than simply putting the big light on.

Warm up

Gentle exercise before you eat is a smart move, particularly combined with some fresh air. A walk or spin on the rollers helps kick-start your systems.

Breakfast

Eat a high-carbohydrate breakfast, and make sure it is plain and palatable, as your digestive system is not firing on all cylinders early in the day. Porridge is a safe, reliable choice for most people. And, of course, make sure you are well hydrated (this applies to the night before too).

Written by Dr Mark Homer

This feature originally appeared in the print edition of Cycling Weekly, on sale in newsagents and supermarkets, priced 3.25.

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Is there a best time to train? A sports scientist investigates - Cycling Weekly

Anatomy of a heatwave – Cosmos

By Dana M Bergstrom, Andrew Klekociuk, Diana King and Sharon Robinson

While the world rightfully focuses on the COVID-19 pandemic, the planet is still warming. This summers Antarctic weather, as elsewhere in the world, was unprecedented in the observed record.

Our research, published in Global Change Biology, describes the recent heatwave in Antarctica. Beginning in late spring east of the Antarctic Peninsula, it circumnavigated the continent over the next four months. Some of our team spent the summer in Antarctica observing these temperatures and the effect on natural systems, witnessing the heatwave first-hand.

Antarctica may be isolated from other continents by the Southern Ocean, but has worldwide impacts. It drives the global ocean conveyor belt, a constant system of deep-ocean circulation which transfers oceanic heat around the planet, and its melting ice sheet adds to global sea level rise.

Antarctica represents the simple, extreme end of conditions for life. It can be seen as a canary in the mine, demonstrating patterns of change we can expect to see elsewhere.

Most of Antarctica is ice-covered, but there are small ice-free oases, predominantly on the coast. Collectively 0.44% of the continent, these unique areas are important biodiversity hotspots for penguins and other seabirds, mosses, lichens, lakes, ponds and associated invertebrates.

This summer, Casey Research Station, in the Windmill Islands oasis, experienced its first recorded heatwave. For three days, minimum temperatures exceeded zero and daily maximums were all above 7.5C. On January 24, its highest maximum of 9.2C was recorded, almost 7C above Caseys 30-year mean for the month.

The arrival of warm, moist air during this weather event brought rain to Davis Research Station in the normally frigid, ice-free desert of the Vestfold Hills. The warm conditions triggered extensive meltwater pools and surface streams on local glaciers. These, together with melting snowbanks, contributed to high-flowing rivers and flooding lakes.

By February, most heat was concentrated in the Antarctic Peninsula at the northernmost part of the continent. A new Antarctic maximum temperature of 18.4C was recorded on February 6 at Argentinas Esperanza research station on the Peninsula - almost 1C above the previous record. Three days later this was eclipsed when 20.75C was reported at Brazils Marambio station, on Seymour Island east of the Peninsula.

The pace of warming from global climate change has been generally slower in East Antarctica compared with West Antarctica and the Antarctic Peninsula. This is in part due to the ozone hole, which has occurred in spring over Antarctica since the late 1970s.

The hole has tended to strengthen jet stream winds over the Southern Ocean promoting a generally more positive state of the Southern Annular Mode in summer. This means the Southern Oceans westerly wind belt has tended to stay close to Antarctica at that time of year creating a seasonal shield, reducing the transfer of warm air from the Earths temperate regions to Antarctica.

But during the spring of 2019 a strong warming of the stratosphere over Antarctica significantly reduced the size of the ozone hole. This helped to support a more negative state of the Southern Annular Mode and weakened the shield.

Other factors in late 2019 may have also helped to warm Antarctica. The Indian Ocean Dipole was in a strong positive state due to a late retreat of the Indian monsoon. This meant that water in the western Indian Ocean was warmer than normal. Air rising from this and other warm ocean patches in the Pacific Ocean provided energy sources that altered the path of weather systems and helped to disturb and warm the stratosphere.

Localised flooding appeared to benefit some Vestfold Hills moss banks which were previously very drought-stressed. Prior to the flood event, most mosses were grey and moribund, but one month later many moss shoots were green.

Given the generally cold conditions of Antarctica, the warmth may have benefited the flora (mosses, lichens and two vascular plants), and microbes and invertebrates, but only where liquid water formed. Areas in the Vestfold Hills away from the flooding became more drought-stressed over the summer.

High temperatures may have caused heat stress in some organisms. Antarctic mosses and lichens are often dark in colour, allowing sunlight to be absorbed to create warm microclimates. This is a great strategy when temperatures are just above freezing, but heat stress can occur once 10C is exceeded.

On King George Island, near the Antarctic Peninsula, our measurements showed that in January 2019 moss surface temperatures only exceeded 14C for 3% of the time, but in 2020 this increased fourfold (to 12% of the time).

Based on our experience from previous anomalous hot Antarctic summers, we can expect many biological impacts, positive and negative, in coming years. The most recent event highlights the connectedness of our climate systems: from the surface to the stratosphere, and from the monsoon tropics to the southernmost continent.

Under climate change, extreme events are predicted to increase in frequency and severity, and Antarctica is not immune.

Dana M Bergstrom, Principal Research Scientist, University of Wollongong; Andrew Klekociuk, Adjunct Senior Lecturer, University of Tasmania; Diana King, Research officer, University of Wollongong, and Sharon Robinson, Professor, University of Wollongong

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Anatomy of a heatwave - Cosmos

A look at the anatomy of a good mystery – HNGnews.com

Author and publisher, David Benjamin, whose book talks and workshops include mystery writing, says, Writing a good story is like solving a series of problems, in which language, science, geography, law, imagination and the unexpected are all jumbled together.

By Sharyn Alden

Storytelling has been an integral part of American culture for hundreds of years. Now, while a majority of Americans are in "safer at-home" mode, curling up with a good book is an attractive option.

David Benjamin (www.lastkidbooks.com), author of nine books, including several mysteries, was recently scheduled to present, "The Seven Keys to Storytelling" at the Deforest Public Library. The program will be rescheduled in the future after the library reopens.

The author started his first novel in elementary school reading chapters aloud at St. Marys School in Tomah, Wisconsin. He adapted some of those experiences in his memoir, "The Life and Times of the Last Kid Picked" (Random House, 2002).

A Lifetime of Stories

Today, he draws ideas from a lifetime of living and traveling throughout the world as well as stories gleaned from his own backyard. Some of his well-drawn characters may be found charting paths through Wisconsin mysteries, page-turners he expertly brings to life.

Last year in Paris, where he lives part of the year, he held a writing discussion with the British National Union of Journalists and a writing workshop at the American Library in Paris.

Known for his witty, offbeat writing style, Benjamin splits his time between homes in Madison and France. His credits include journalist, editor, ghost-writer, novelist, satirist, essayist, columnist, travel writer and theater critic. He also worked as a cannery hand in Waunakee and a steelworker in Florida.

His publishing imprint Last Kid Books (lastkidbooks.com) pays homage to Benjamins first published "fiction," "The Life and Times of the Last Kid Picked."

In 2019, Benjamins publishing company received awards from the New York City Big Book Awards in four categories. In addition to a Best Political Thriller award for "Black Dragon," he received a Distinguished Favorite in Crime Fiction for "Threes a Crowd" and Best Romantic Comedy for "A Sunday Kind of Love," which captures the thrill and agony of Green Bay Packers fan-worship. His Wisconsin-based novel, "Summer of 68," was also a Distinguished Favorite in Historical Fiction.

From the Independent Press Awards, he was honored as a Distinguished Favorite in "Mystery for Skulduggery in the Latin Quarter" (the Left Bank area of Paris where he lives), and won Best Essay Collection for "Almost Killed by a Train of Thought."

Recipe for a Memorable Mystery

Benjamin is often asked what elements make a memorable who-done-it.

He says, You can write a mystery without a murder, but the following three elements these three Ms actually tend to be in place.

Maguffin Coined by Alfred Hitchcock, a maguffin is an item that motivates characters, creates conflict and propels the plot.

Moriarty The elusive, brilliant and dangerous mastermind.

Marlowe A flawed but stubborn sleuth who wont let go. Think Sam Spade or Philip Marlowe.

Each of Benjamins mysteries, "Skulduggery in the Latin Quarter," "Black Dragon," and "Jailbait," have these ingredients, and a few laughs as well.

James Fallows, of The Atlantic magazine calls the thriller "Black Dragon," "A genuine page-turner, full of enough action, suspense, sly humor, and sharp, cultural insights.an enjoyable and provocative book."

His recent novel "Jailbait," takes place in a fictional Wisconsin town called Hercules, located somewhere on Highway 33 east of La Crosse. "Hercules is typical of a hundred little towns all over western Wisconsin," he notes. "Heck, all over America."

During talks he discusses plot, structure and legwork behind the crafting of mysteries, including his own award-winning books. He is currently in production on his eighth Last Kid Books title, "They Shot Kennedy," a fictional snapshot of microhistory set in November, 1963.

There is an irony to this idea of boiling down the murder mystery to three bullet points, because thats a formula, says Benjamin. And I dont cant write the sort of formula potboilers that sell like hotcakes. He noted that the elements of maguffin, moriarty and marlowe are merely the basis for an infinite range of variations. Using examples from his own mysteries, as well as the work of other writers, he offers insights into the creative possibilities of the genre.

However the author puts the pieces together, the story should be accessible, says Benjamin. The reading should be fun. And thinking talking about it afterwards should prolong the pleasure.

Looking back, reflected by the multitude of books, manuscripts and essays hes written, the author certainly knew what he wanted to do when he grew up tell stories in front of people. He says. "Im still doing what I discovered, as a sort of vocation, in grade school. From that moment, Ive always believed that stories are the clues to solving the riddles of life."

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A look at the anatomy of a good mystery - HNGnews.com