COVID-19: T cells offer clues to the potential power of Roche’s Actemra – FierceBiotech

The successful activation of T cells is critical to the immune system's ability to clear infections. A new retrospective study from China found that COVID-19 patients had remarkably low T-cell counts in their blood. And they had sky-high levels ofsome pro-inflammatory cytokines such as IL-6which Roches Actemra targets.

Actemra has previously shown promise at controlling potentially life-threatening cytokine storm in COVID-19 patients in China and France, and Roche is running a large phase 3 to confirm its effectiveness in treating patients with COVID-19.

In thestudy from China, published in Frontiers in Immunology, a group of scientists analyzed T-cell counts in 499 COVID-19 patients being treated for the disease in the city of Wuhan. They found a negative correlation between T-cell numbers and cytokines. The team suggested that the novel coronavirus doesnt attack T cells directly, but rather triggers an overproduction of cytokines, which in turn contributes to the depletion and exhaustion of T cells.

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The Chinese researchers noticed that about 76% of patients had insufficient T cells, and the level was much lower in those in intensive care. They then examined the concentrations of cytokines from the blood of these patients and found that the levels of TNF-alpha, IL-6 and IL-10 were significantly increased in infected patients. The elevation was even more pronounced in ICU patients.TNF-alpha is known to promote T-cell death, and dysregulated IL-6 has been shown to induce chronic inflammation.

As the patients gradually recovered, their T cell counts improved, while levels of those cytokines dramatically declined. Sothe researchers hypothesize that the depletionof T cells in COVID-19 patients may be the result ofcytokines impedingT-cell survival or proliferation.

Whats more, the T cells that did survive showed signs of exhaustion, with markedly higher expression of immune-inhibitory factors such as PD-1 and Tim-3 on their surface. That was a sign that their functioning was impaired, the researchers reported.

Based on these findings, the team arguedthe secretion of pro-inflammatory cytokines likely does not come from T cells, butthat the cytokine storm may promote the death of the critical immune cells.

RELATED:Reviving tired T cells to improve immuno-oncology treatments

Finding new ways to restore the vigor of immune cells hasbeen of interest in the biomedical research community, notably in oncology. A team at the University of Pennsylvania, for example, found that a protein called TOX in T cells controls the balance of effector T cells and exhausted T cells, suggesting it could be targeted to improve immuno-oncology treatments. And scientists at the La Jolla institute for Immunology recently showed that crippling all three proteins of Nr4a transcription factors could rejuvenate exhausted CAR-T cells to fight solid tumors in mice.

Based on their findings, the Chinese team suggested thatfuture COVID-19 research should focus on identifying more drugs that provide much-needed support toT cells.

We should pay more attention to T cell counts and their function, rather than respiratory function of patients, the studys corresponding author, Yongwen Chenof the Third Military Medical University in China, said in a statement, adding that more urgent, early intervention may be required in patients with low T lymphocyte counts.

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How to tell the difference between coronavirus symptoms and plain old allergies – Holmes County Times Advertiser

Allergy symptoms are likely to increase during the next two to three weeks as pollen counts grow into the thousands, said Leonard Bielory, professor of medicine, allergy, immunology and ophthalmology at Hackensack Meridian School of Medicine.

This content is being provided for free as a public service to our readers during the coronavirus outbreak. Please support local journalism by subscribing to the Northwest Florida Daily News or the Panama City News Herald .

WOODLAND PARK, N.J. With coronavirus restrictions in place, interactions with nature might be limited to a quick walk through the neighborhood, but its not hard to notice spring has sprung bringing allergy season with it.

Allergy symptoms are likely to increase as pollen counts grow into the thousands, said Leonard Bielory, professor of medicine, allergy, immunology and ophthalmology at Hackensack Meridian School of Medicine.

That raises a new dilemma: Some allergy symptoms, such as coughing, mimic signs of COVID-19. So how can sufferers tell the difference?

MARCH 15, 2020: What does the coronavirus infection do inside your body?

The combination and severity of symptoms is telling.

Patients with asthma or allergies who cough and experience breathlessness can resolve their symptoms with inhalers or prescription medication, Bielory said.

But if a patient has COVID-19, those solutions wont work and the symptoms are likely to be far more extreme. Coronavirus patients can have severe difficulty breathing. That's why many admitted to hospitals need the assistance of ventilators, which move air in and out of the lungs mechanically.

People who develop viruses, including COVID-19, may experience an associated fever within 24 to 72 hours of infection, Bielory said.

Fever is a major differential, he said. You dont normally get fever with allergies.

COVID-19 patients may also develop gastrointestinal symptoms and muscle aches and pains, according to the Asthma and Allergy Foundation of America. Up to two-thirds of them may lose their sense of smell, Bielory said. None of those symptoms is associated with allergies.

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COVID-19: blood plasma treatment tested at Guy’s and St Thomas’ – London SE1

A blood plasma treatment for COVID-19 is to be tested at Guy's and St Thomas' as part of a new trial.

The treatment known as 'convalescent plasma' is being tested as a treatment for patients who are severely ill with COVID-19 as part of the national priority trial REMAP-CAP. Supported by the National Institute for Health Research, REMAP-CAP is an international trial testing different treatments for patients who are severely ill with COVID-19.

The 'convalescent plasma' treatment involves blood plasma donations from patients who have recovered from COVID-19. This plasma is transfused into COVID-19 patients whose bodies are not producing enough of their own antibodies against the virus, in an attempt to support the patients fighting the disease.

The trial is co-led by Dr Manu Shankar-Hari, a consultant in intensive care medicine at Guy's and St Thomas', along with experts from NHS Blood and Transplant and the University of Cambridge.

The research lab run by Dr Shankar-Hari within the King's College London School of Immunology and Microbial Sciences is coordinating the underpinning science behind the convalescent plasma treatment.

Dr Shankar-Hari, who is also an NIHR Clinician Scientist and Reader and Consultant in Intensive Care Medicine at King's College London, said: "At the moment, there is no proven treatment for COVID-19. Convalescent plasma is a promising treatment that could help patients whose bodies aren't producing enough antibodies to curb the disease. This trial will help us understand whether the treatment should be used more widely to treat COVID-19.

"We are incredibly grateful to all the patients who are taking part in our COVID-19 trials and their families. At a difficult time for them, our patients are taking part in studies that will help us to understand more about how to treat the condition."

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How to tell the difference between coronavirus symptoms and allergies – USA TODAY

As flu season comes to an end and allergy season starts to heat up, there may be concerns about symptoms that mimic the new coronavirus COVID-19. Wochit

WOODLAND PARK, N.J. With coronavirus restrictions in place, interactions with nature might be limited to a quick walk through the neighborhood, but its not hard to notice spring has sprung bringing allergy season with it.

Allergy symptoms are likely to increase during the next two to three weeks as pollen counts grow into the thousands, said Leonard Bielory, professor of medicine, allergy, immunology and ophthalmology at Hackensack Meridian School of Medicine.

If it wasnt for the cold snap, wed be having an incredible amount of pollen right now, Bielory said Monday. Once it warms up, with the rain weve gotten, its going to be quite an intense opening season for trees. Its going to explode.

That raises a new dilemma:Some allergy symptoms, such as coughing, mimic signs of COVID-19. So how can sufferers tell the difference?

Coronavirus: These are the 6 new possible symptoms the CDC added to its list

Prevention: How to clean, reuse or hack a coronavirus mask

The combination and severity of symptoms is telling.

Patients with asthma or allergies who cough and experience breathlessness can resolve their symptoms with inhalers or prescription medication, Bielory said.

But if a patient has COVID-19, those solutions wont work and the symptoms are likely to be far more extreme. Coronavirus patients can have severe difficulty breathing. That's why many admitted to hospitals need the assistance of ventilators, which move air in and out of the lungs mechanically.

People who develop viruses, including COVID-19, may experience an associated fever within 24 to 72 hours of infection, Bielory said.

Fever is a major differential, he said. You dont normally get fever with allergies.

COVID-19 patients may also develop gastrointestinal symptoms and muscle aches and pains, according to theAsthma and Allergy Foundation of America. Up to two-thirds of them may lose their sense of smell, Bielory said. None of those symptoms is associated with allergies.

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Coronavirus second wave panic as scientists admit they’re ‘flying blind’ over immunity – Express.co.uk

Danny Altmann, Professor of Immunology at Imperial College London, admitted scientists currently do not have any idea whether confirmed coronavirus patients will develop immunity from catching the virus for a second time.During a remote Commons Science and Technology Committee meeting, Professor Altmann also raised serious concerns about lifting the UK-wide lockdown without sufficient knowledge of the virus or a vaccine.

He said: Immunologists when they are studying live infection or vaccination get very obsessed with these things called quarrians of protection.

And that means all the tests you can do, all the measurable, give you a number to quantify whether the likelihood is this person would be protected next time they meet this bug.

So that is the thing we need to know we kind of don't know the foggiest notion of for this infection at the moment.

Britons have been living under restrictions since March 23 and Professor Altmann has cast serious doubt as to whether social distancing measures can be lifted without accurate anti-body testing and knowledge of exactly who is carrying the virus.

The medical expert is also adamant it would take at least another six months to gather enough evidence in order to fully understand the disease.

He said: "As an immunologist and knowing how desperately lethal this virus can be, I'd be very worried about any assumptions on those grounds - terribly worried.

"For a virus we've known about since January, it's been a very steep learning curve.

"Without really good antibody testing and seroprevalence in the population, we're flying blind.

"We haven't got a clue who's had it, how many have had it, where they've had it, or where we stand for the future for second waves.

READ MORE:Angela Merkel at risk of reimposing lockdown as infection rate spikes

Up to 1,102 participants will be recruited across multiple study sites in Oxford, Southampton, London and Bristol.

The Department for Health has confirmed a further 586 patients have died from COVID-19 in UK hospitals.

As of 5pm on Monday the total number of coronavirus fatalities now stands at 21,678.

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Insights on the Worldwide Neuroscience Antibodies and Assays Industry to 2024 – Key Drivers and Challenges – Yahoo Finance

Dublin, May 01, 2020 (GLOBE NEWSWIRE) -- The "Global Neuroscience Antibodies and Assays Market 2020-2024" report has been added to ResearchAndMarkets.com's offering.

The author has been monitoring the global neuroscience antibodies and assays market and it is poised to grow by USD 1.36 bn during 2020-2024, progressing at a CAGR of 8% during the forecast period. The reports on global neuroscience antibodies and assays market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors.

The report offers an up-to-date analysis regarding the current global market scenario, latest trends and drivers, and the overall market environment. The market is driven by technological advances. In addition, advances in neuroscience instruments is anticipated to boost the growth of the global neuroscience antibodies and assays market as well.

Key Trends for global neuroscience antibodies and assays market growthThis study identifies advances in neuroscience instruments as the prime reasons driving the global neuroscience antibodies and assays market growth during the next few years.

Prominent vendors in global neuroscience antibodies and assays marketWe provide a detailed analysis of around 25 vendors operating in the global neuroscience antibodies and assays market, including some of the vendors such as Abcam Plc, Bio-Rad Laboratories Inc., Cell Signaling Technology Inc., F. Hoffmann-La Roche Ltd., GenScript Biotech Corp., Merck KGaA, Rockland Immunochemicals Inc., Santa Cruz Biotechnology Inc., Tecan Group Ltd. and Thermo Fisher Scientific Inc.

The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to an analysis of the key vendors.

Key Topics Covered:

1. EXECUTIVE SUMMARY2. SCOPE OF THE REPORT

3. MARKET LANDSCAPE

4. MARKET SIZING

5. FIVE FORCES ANALYSIS

6. MARKET SEGMENTATION BY PRODUCT

7. CUSTOMER LANDSCAPE

8. GEOGRAPHIC LANDSCAPE

9. DRIVERS AND CHALLENGES

10. MARKET TRENDS

11. VENDOR LANDSCAPE

12. VENDOR ANALYSIS

13. APPENDIX

For more information about this report visit https://www.researchandmarkets.com/r/olpv03

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

CONTACT: ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.comFor E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

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Insights on the Worldwide Neuroscience Antibodies and Assays Industry to 2024 - Key Drivers and Challenges - Yahoo Finance

New Web and APP platform offers Neuroscience Sports Breakthrough Approach to Calisthenics and Body Workouts Training – Life Pulse Health

UNITED STATES 04-30-2020 (PRDistribution.com) Biomedical expert Jean Fallacara also known as the Cyborg has teamed up with elite coaches and professional athletes from CalisthenixPro Team to create a new unique web application platform that offers a new approach to calisthenics training. Calisthenics is a great form of exercise that involves a variety of movements carried out rhythmically with minimal equipment to exercise larger muscle groups. Recent research indicates that the exercise boosts the brainpower.

The new web application Cyborgainz combines neuroscience to increase the brains neuroplasticity, create and strengthen motor pathways faster. This often makes is easier and faster to master any skills. Individuals using the application will be offered custom workout and personalized plans that match each of the programs with an individuals specific goals and objectives.

Speaking about the platform, Jean Fallacara who has over 20 years experience in the science technology field emphasized the need to train the body and mind.

If the body is being trained, shouldnt athletes also train the brain? The difference between good athletes and great athletes is that great athlete knows the way to maximize strength and potential is to train mind and body.We created Cyborgainz for this purpose. Our platform helps you understand the neurobiological effects of your training helping you to be stronger, faster, quicker and more explosive like a Cyborg

The specific flexible workout programs on the platform have been designed by a team of calisthenics & freestyle experts to help the trainer decode any skill that they have been desiring to learn. Since each of the programs is custom built for every person, it also allows for important individual circumstances such as injuries or allergies. The testing activity of the different forms of brain stimulation including transcranial direct current stimulation (TDCS) is carried out on this application.

The meal plan created for the client consists of a 7 day diet plan and clients have a choice of the different meals they prefer. For instance, one can decide whether to have Italian or international cuisine or general, vegetarian or paleo diet. A shopping list will also be provided for the client as they strive towards achieving their body and mind goals. Exercises to be carried out are entered into the system together with other additional information such as the exercise level that is beginner, intermediate and advanced. The exercise description and instructions including a video on how to carry it out and another part for filling in injury information just in case.

The utilization of neuroscience in the sports is something that has been studied by neuroscientists for a long time. Neuroscience research has also revealed the differences between the brain activity of the top performers and the novices. According to research conducted on Neymar da Silva Santos, a top Brazilian player, the loading of working of the brain plays a major role in influencing the cognitive aspects during performance such as the ability to predict and detect the actions of other players in the case of the footballer.

By combining mind and body training, Cyborgainz to change the approach to calisthenics training and body building.

About Jean Fallacara

Born of a disruptive spirit and an imaginative mindset, Jean Fallacara has been working as an experienced executive focused on technology products for the science business. He has over 20 years of experience in this field where he has founded and led a number of science-technology companies. He is also an expert in strategic planning, operations, investment management, and marketing. His specialized skills in achieving strategic objectives with the primary focus on increasing shareholders wealth through merger, acquisition, new business developments, or undertaking share offering and raising capital has seen him work with a number of companies helping them to create meaningful relationships with their clients, partners and, the communities in which they operate. Currently, Jean Fallacara is the Founder CEO at Z-SCI Corporation headquartered in Westmount, Qc- Canada with US branches and manufacturing bases in South-Korea. The firm is an international company with a successful record of developing laboratory equipment for the biomedical market. To learn more about calisthenics, find him on his Instagram: @cyborggainz

Media Contacts:

Company Name: CyborgainzFull Name: Jean FallacaraPhone: Email Address: Send EmailWebsite: https://cyborggainz.com/

For the original news story, please visit https://prdistribution.com/news/new-web-and-app-platform-offers-neuroscience-sports-breakthrough-approach-to-calisthenics-and-body-workouts-training.html.

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What the Tech? App of the Day: iTunes U – Alabama News Network

Posted: May 1, 2020 6:58 PM CDT

Updated: May 1, 2020 7:01 PM CDT

by Alabama News Network Staff

While youre stuck, I mean safe at home, why not put some of that time to good use? Like getting an Ivy League education. Or learn new skills, for free!

It may be the most valuable app on an iPhone. iTunes U is a stock iPhone and iPad app from Apple.

Teachers use it for class assignments and creating lessons, but you can use it to go back to school. The iTunes U app lists courses from hundreds of colleges and universities around the world.

From community colleges to Ivy League schools such as Harvard and Princeton. Lets take a look. At Yale University, yes THAT Yale, I found an introduction to psychology with over 80 lectures and even the class literature.

This 2nd semester lecture on The Brain. I can listen to the professor in front of the classroom. Yale has also made available some of the required reading material.

While this class is audio only, others are video lectures. Just like you have a seat in the classroom.

Almost all of the classes and lectures are free. You can search by school, by subject. You can finally try your brain on neuroscience, economics, engineering or the arts. If youve always wanted to start a business or side-hustle, there are a number of courses on entrepreneurship at Stanford University.

Apple has whittled down the number of courses recently but there are still 87 available and thousands of educational video and audio files from top universities, museums and public media organizations.

If you want to go back and take some refresher courses at the high school level, you can do that too.

Some colleges and universities have made entire courses available in the app.

Apple hasnt done much of anything with iTunes U in recent years and the content can also be found in the Apple podcast app, but Ive found it easier to search and fine courses within the iTunes U app.

If youre looking for a way to spend this time at home, its worth opening the app and browsing around. No ACT score or scholarship required.

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What the Tech? App of the Day: iTunes U - Alabama News Network

Humans of UCSF: Expand Your Learning – Synapse

What are you doing during the COVID-19 isolation order?

Trying to read all the papers and books I haven't found the time for, but mostly checking for Amazon Fresh delivery slots and listening for trucks that might be restocking toilet paper at my corner shop.

Useful tip(s) for others in self-isolation?

Try a class. If you aren't taking classes over zoom, you might find something useful (and free!) on Coursera or EdX. I was disappointed that a summer course was canceled, but I found a similar computational neuroscience class online.

Read some fiction. It can be a nice break from scientific papers and scientific writing. The San Francisco public library is closed, but they still have e-books and audiobooks online (for free). Pro tip: If your book is not available on one app, try another (there are 3 total). I just finished Half of a Yellow Sun by Chimamanda Ngozi Adichie, and I'm starting Love in the Time of Cholera.

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Humans of UCSF: Expand Your Learning - Synapse

As COVID-19 forces conferences online, scientists discover upsides of virtual format – Science Magazine

Jacelyn Peabody Lever of the University of Alabama atBirmingham,goes virtual for the American Physician Scientists Association annual meeting.

By Michael PriceApr. 28, 2020 , 4:20 PM

Biochemist Kathleen Prosser wasnt planning to present her research at a conference this spring. But when COVID-19 caused organizers to cancel a series of local chemistry meetings across Canadacalled Inorganic Discussion Weekendsand offer a virtual alternative, she signed up to give a talk. Prosser, a Canadian citizen who is a postdoc at the University of California (UC), San Diego, figured shed be talking mostly to fellow Canadians. But by going virtual, she gained an international audience. The day after her talk she heard from a chemist in Australia, asking for more details and hinting at a future collaboration. The time zone difference would not have allowed them to see it live, but they watched it [afterward], she says.

As the novel coronavirus outbreak shutters businesses and disrupts everyday life for billions around the globe, massive annual conferences and small society meetings alike have moved online. The new format poses numerous technical and organizational challenges, but it also offers opportunitiesfor reaching wider audiences, reducing the carbon footprint of meeting travel, and improving diversity and equity. For some meetings, the shift may be permanent.

The scientific community is making lemonade out of lemons, Prosser says. Its taking [a situation] thats really quite horrible and providing people a way to connect in spite of it all.

In many ways, virtual conferences offer a better experience, says Russ Altman, associate director of the Stanford Institute for Human-Centered Artificial Intelligence (AI). Altmans institute had planned an inperson conference this month, but COVID-19 forced organizers to scuttle it. In its place, they threw together a virtual conference to discuss how AI can help scientists fight the ongoing pandemic. The event was a smashing success, Altman says. The original conferencemeant to focus on how AI intersects with neuroscience and psychologywould have drawn a few hundred attendees, but 30,000 people tuned in to the online version.

Altman says the virtual environment allowed moderators to better control the flow of discussion and questions from the audience. By privately messaging one another behind the scenes, they were able to discuss how a session was going and make adjustments in real time. For example, we had one panelist who we thought was contributing a little bit too much, he says. The moderators responded by using private messages to encourage others to speak, and they made a mutual decision to ask questions designed to draw comment from other, less vocal panelists. Thats hard to do in person because everyone is up [on stage] and you cant have a backchannel conversation.

During the audience question period, the moderators didnt open up the virtual floor for anyone to speak. Instead, they asked audience members to type their questions, and a little army of people reading chat windows prioritized the most insightful inquiries. Its not just one person who ran up to the microphone after a talk and takes up all the airtime, Altman says.

Prosser had a similar experience with her chemistry talk, noting that because moderators could screen questions from the audience, she didnt face the nonquestion questions you sometimes see at meetings.

Scientists acknowledge that virtual conferences cant entirely replicate the conference experience, which normally involves impromptu meetings in hallways and other social get-togethers. Humans are a social species, notes Jennifer Kwan, a clinical fellow at the Yale School of Medicine. Were used to being able to see body language, being able to interface with someone in person. So virtual meetings might lose some of their appeal once stay-at-home requirements loosen, she says.

Even so, Kwan sees growing support for online opportunities. She organized a virtual session this month for the annual meeting of the American Physician Scientists Association, one of the first large conferences to go virtual. Close to 500 attendees tuned in to her session, which featured Francis Collinsdirector of the U.S. National Institutes of Healthas a guest speaker and focused on ways to support early-career scientists amid the turmoil of the coronavirus outbreak. Kwan says the success of her societys meeting has spurred the discussion of [hosting] additional virtual sessions in the future.

For some societies, the COVID-19 crisis hasnt so much started discussions about virtual conferences as accelerated them. Last fall, the Cognitive Neuroscience Societys governing board began to ponder how to make future meetings more accessible, affordable, and environmentally friendly. A lot of our membership had started to ask about our carbon footprint, says George Mangun, the director of the Center for Mind and Brain at UC Davis who sits on the societys governing board. Originally, board members discussed holding a portion of the 2021 meeting virtually. But when the pandemic hit, they adjusted their strategy and now plan to hold the entire 2020 meeting online in May. If the conference succeeds this year, Mangun notes, it will further solidify the societys march toward virtual meetings.

Altman agrees. Whether we like it or not, the scientific community is going to very quickly come to expect this.

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As COVID-19 forces conferences online, scientists discover upsides of virtual format - Science Magazine