Game theory and COVID-19: Major defense project pivots to explore how to coordinate safe behavior – University of Michigan News

ANN ARBORShedding light on how officials at different levels of government can work together to maximize COVID-safe behavior is a new goal of a multiscale game theory project funded with $6.5 million from the Department of Defense.

Mingyan Liu

Mingyan Liu, leader of the project and the Peter and Evelyn Fuss Chair of Electrical and Computer Engineering, presented her teams work at a recent Call to Arms virtual conference, held by the National Science Foundations Networking Technology Systems group.

When human behavior is competitive, we dont use resources in the way that is most efficient for the communityas seen in behaviors like mask, sanitizer and toilet paper hoarding. But most of our decisions about how to behave arent entirely individualistic. We make them as part of a community. We are swayed both by leadershipand the incentives and disincentives that they can offeras well as altruism.

Most of the literature in game theory examines individual behavior, but Liu and her colleagues are exploring what happens when decisions are made at multiple scales. This is particularly relevant during the current COVID-19 pandemic, when decisions are made by individuals, local governments, state governments and nations. Do we act for the common good, or do we do what we perceive as serving our individual interests?

An example, in the present context, is someone who ignores shelter-at-home orders and essentially benefits from other peoples decision to comply with the order. This is whats called freeriding, Liu said.

Freeriders are protected from the virus through the decrease in transmission brought about by everyone who stays at home. This principle also applies to local and state officials making their own calculations about mitigating the risk of COVID-19. One state with a high COVID-19 case load may decide to shut down, while a neighboring state with a smaller case load may have the advantage of staying open, again benefiting from the free rider effect.

The global pandemic is the most salient threat we face at the moment, said Purush Iyer, program manager at the Army Research Office, an element of the U.S. Army Combat Capabilities Development Commands Army Research Laboratory.

While the U.S. Armys interest in network games includes understanding the impact of the adversarial groups in a host population, electronic warfare, and distributed weapon systems, we fully support exploring the impact of measures to control the spread of disease.

To begin with, the team is exploring how to model compliance or lack of compliance regarding COVID-19 orders and recommendations in their game-theory framework. The protective behaviors include not going out, wearing a mask when going out, and handwashing and sanitizer use when returning from being out.

The factors that may influence compliance often include the prevalence of COVID-19 in the local community, a persons vulnerability or proximity to vulnerable individuals, and general awareness. But they may also be affected by the timing of the order and even the words and phrases chosen to give the justification and restrictions. This aspect of the analysis will allow the team to then investigate communitywide behavior as a result of high-level policies.

Liu plans to connect behaviors identified from such data with COVID-19 case data to discover which restrictions and recommendations are most effective.

Were also interested in understanding what additional mechanisms or policies could be introduced to make the overall system more efficientfor instance, enabling more collaboration among communities rather than competition, Liu said.

She cited the way that states are currently fighting one another for federal supply of medical equipment even as some come together on a plan to begin reopening the economy.

For now, Lius team is best equipped to model strategic decisions associated with social distancing at the individual and community levels, but they have plans to include economic concerns as well. The state that is able to remain open because its neighbors are closed is a free rider in the sense of limiting virus spread, but it may also play an important economic role in manufacturing and distribution, helping to head off shortages.

The project is titled Multi-Scale Network Games of Collusion and Competition.

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Game theory and COVID-19: Major defense project pivots to explore how to coordinate safe behavior - University of Michigan News

Get outside, but respect the natural world – Opinion – Cape Cod Times

A couple of years ago, during the longest government shutdown in American history, the caretakers of numerous national parks reported an uptick in vandalism and other careless human behavior, with people trampling over restricted areas, killing wildlife, littering, dumping trash and damaging natural habitats. Now, in the midst of a national emergency that has largely brought the country to a halt, more people are rediscovering the great outdoors, taking the time to enjoy visits to natural resources and to get out into nature. All of this is good, as it fosters a deeper connection with the world around us and reminds us that we are all closely linked to the environment. At the same time, it is crucial that, even as we enjoy and embrace the world of which we are an inextricable part, we do not directly or indirectly damage it.

Such is the problem at the Cape Cod National Seashore. A popular destination for decades, the Seashore routinely attracts between 3 million and 4 million visitors every year, and as in past springs, the warmer weather has brought a corresponding rise in the number of people visiting the park.

This spring, however, is proving to be like no spring in recent memory, and Park Service personnel are living with what appears to be one of the unforeseen consequences of the COVID-19 outbreak; that is, a rise in a variety of illegal activities, including dumping and vandalism on the Seashore grounds, as well as the more pedestrian problems of a spike in the number of dogs being walked off leash as well as the number of ATVs, which are banned from the Seashores many trails.

In an interview with Deputy Chief Ranger Ryan White, Cape Cod Times reporter Denise Coffey discovered that although many of these types of incidents are traditional problems for the Seashore, there has been a rise in the number of incidents in recent weeks. White spoke about instances where household trash was dumped at Wellfleets Great Island and construction debris was left at Easthams Doane Rock area.

The problem is not simply one of people leaving a mess for others to clean up, although that is in and of itself bad enough; this carelessness can also negatively affect the endangered wildlife that calls the Seashore home. White pointed specifically to terns and piping plovers, both of which are beginning to nest.

The issue here is not with the vast majority of visitors who come to the National Seashore and use the resources respectfully, follow the rules, and cart out all of the trash they produce. No, the problem is with the few who have decided that because the parks lands are extensive and that all of the public buildings are closed, this somehow grants them license to treat this precious jewel with neglect and selfishness, using it as both their trash can and their personal park.

Compounding the issue is the fact that many people are home with additional time on their hands. White said he believes this may have led to a surge in the number of home remodeling projects, and a consequential increase in the amount of trash produced. Also adding to the problem is the fact that as the number of coronavirus cases continued to grow, some towns temporarily shut down their building waste disposal areas to protect their employees, leaving homeowners and builders with the dilemma of what to do with their construction debris.

Given that the states order closing nonessential services remains in place, and the fact that the number of COVID-19 cases in the commonwealth continues to grow, there is little certainty as to when the Seashore shutdown might be lifted. Even in times without a global pandemic going on, park officials could not hope to fully monitor the more than 43,600 acres that make up the Seashore.

Now, perhaps more than ever before, it is up to all park visitors to help monitor the grounds, keeping an eye out for those who have decided to not follow the rules, and, where appropriate, perhaps reminding them that the Cape Cod National Seashore belongs to everyone. In times where discretion may be more appropriate than confrontation, informing Seashore personnel about a problem will go a long way toward helping preserve this unique treasure.

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Get outside, but respect the natural world - Opinion - Cape Cod Times

Children of the pandemic: How will kids be shaped by the coronavirus crisis? – Science Magazine

By Joel GoldbergApr. 30, 2020 , 11:15 AM

Sciences COVID-19 reporting is supported by the Pulitzer Center.

Health professionals face a massive challenge in responding to the coronavirus. Child psychologists are no exception as they deal with mental crises in children caused by the pandemics upheaval. Some scientists see the outbreak asa natural experimenta time when a real-life event can be used to track and study changes in everything from ecosystems to human behavior. Events such as 9/11, Hurricane Katrina, and the 2008 earthquake in Sichuan, China, have already helped mental health researchers see how young people typically react during a crisis. Now, two studiesone in Toronto andanother in Baltimorewill monitor the emotions and behaviors of children and teens through this pandemic. What they reveal may teach parents and other adults how to help children in later waves of the coronavirusor during the next major crisis.

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Children of the pandemic: How will kids be shaped by the coronavirus crisis? - Science Magazine

‘Face to Face Time’ Review: Izzy Shill’s SXSW short film is a hilarious case study of insecurity and deceit – MEAWW

Spoilers for Face to Face Time

2020 has witnessed a massive shift in human behavior. Thanks to the coronavirus pandemic, being locked inside homes has become a reality for millions and millions of people across the globe. A state of lockdown, however necessary it is, does not change the fact that we still need contact with other human beings. Subsequently, video chats have become our new best friend. In that respect, Izzy Shills SXSW short film Face to Face Time comes as a rude shock.

The six-minute-something film that stars Shill as Claire and Sean Patrick McGowan as Danny, a man shes been out on two dates with and has a big crush on, is disturbingly funny while being painfully human. It begins with Claire preparing herself. She tidies her dress, makes sure her breasts look good, cleans her bed and then rolls over it a bit to make it just the right amount of messy. She obsesses over every detail in the frame. What frame? The frame of her phone camera as she hits Danny up on FaceTime.

Claires prep, as one could foresee, is met with lackluster enthusiasm from the man of her recent dreams. But it only gets worse. Aside from commenting that Claire looks like a cam girl because of the way she had placed her phone, Danny spends more time texting than actually paying attention to her. And yet, things get worse.

When Claire tries to initiate some extremely awkward FaceTime sex, Danny pays a bit more attention. But he seems entirely too interested in getting his own rocks off rather than having an intimate time with Claire. He makes inane comments like nice bra, whats the color of your underwear, while violently masturbating to what he sees on the screen. Even as Claire tries to make the experience hotter, Danny already looks like hes about to finish. And then things get even worse.

The laptop or iPad or whatever Danny was talking to Claire on, tilts downward and we catch a glimpse of whats happening in the southern hemisphere. Dannys supposed crescendo of passion was an act. He was only pretending to masturbate. Obviously, Claire is hurt. She feels angry and disgusted and sad and decides to leave. In a bid to save himself, Danny tries to flatter, says he likes her, and then starts to explain why he was acting turned on.

As Claires interest piques, the chat hangs and the screen freezes.

Shills film is positively a nightmare for all couples and would-be couples who find themselves separated by the COVID-19 lockdown. It begs them to question if their passionate escapades on video chats are as real as they seem. If Gone Girl managed to make partners mistrust each other, wondering if the other was always planning to ruin their lives, Face to Face Time plants a hilarious seed of mistrust among those who partake in sexting, not just now, but really at any time.

Both Shill and McGowan are fantastic in their performances as they emulate the tropes of the needy and the casually disinterested. The story despite its seemingly trivial subject matter makes a delightful case study of human behavior in the space of technology-based communication. Shills writing and performance also bring out themes of insecurity, low self-esteem, and measuring ones self-worth in external loci.

In just about six minutes, this film entertains, tickles, and makes you self-conscious, forcing you to reevaluate your past experiences. And by any standard, thats a spectacular feat.

'Face to Face Time' is part of Amazon Prime Videos SXSW 2020 Film Festival Collection which is available to be streamed from April 27May 6.

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'Face to Face Time' Review: Izzy Shill's SXSW short film is a hilarious case study of insecurity and deceit - MEAWW

Experts Warn COVID-19 May Not Disappear During Warm-Weather Months – Complex

About a month before coronaviruswas declared a pandemic, President Donald Trumppublicly theorized the deadly disease would "miraculously" go away once the weather heats up.

"And by the way, the virus, they're working hard, looks like by April, you know in theory when it gets a little warmer it miraculously goes away," Trump said during New Hampshire rally in February. "I hope that's true. But we're doing great in our country ... I think it's going to all work out fine. Rough stuff, I tell you, rough, rough stuff."

Experts, however, have pushed back on this theory. Though evidence suggests COVID-19 survives much longer in cooler, drier climates, researchers sayit's unlikelyhumidity and warm temperatures will eradicate the disease. Findings published by MITfound that90 percentof coronavirus transmissions recorded through March 22 occurred in regions with temperaturesbetween 37.4 and 62.6 degrees Fahrenheit. While countries in the Southern Hemisphere, where average temperatures surpassed 64.4 degrees, accounted for fewer than 10 percent of global cases. It's important to take the number of confirmedcases with a grain of salt, as a country's reportedlow infection rate could be attributed to its poor public health infrastructure and lack of testing.

Analysts in Hong Kong have also found that an increase in temperature shortened the timeframe Sars-Cov-2 could be detected. A study published by Lancet Microbeon April 2 states that the virus was "highly stable" when left atat 39 degrees Fahrenheit after two weeks, but when left at 158 degrees, the pathogen was inactive after five minutes.

"Our most striking observation to date is the powerful effect that solar light appears to have on killing the virus both on surfaces and in the air,"William Bryan, head of science and technology at the Department of Homeland Security, said in a statement toBuzzFeed News. "Weve seen a similar effect with both temperature and humidity as well, where increasing temperature, humidity, or both is generally less favorable to the virus."

Ecological modelers at the University of Connecticut also released a study, which has yet to be peer-reviewed, that foundultraviolet light was effective in killing the virus; however, experts cautioned that too much exposure to UV-rays can cause skin cells to become cancerous.

So if research has found coronavirus is harmed byheat, humidity, and sunlight, it would seem as though the pandemic would end once we roll into summer, right? Researchers aren't convinced. Though environment appears to play a role in how long the virus can survive, many experts say human behavior is likely much more important when it comes to combatting coronavirus. Why? Because there's still a lot of questions surrounding disease and how it's transmitted.

Per BuzzFeed:

If it takes a lot of virus to get someone infected, [David Relman, a professor of microbiology and immunology at Stanford University] explained, then perhaps the combined impacts of sunlight, humidity, and temperature on the viruss survivability can greatly cut down transmission. But if it only takes a little bit of virus, especially small particles of the virus that can stay aloft in the air for hours, youll still see transmission inside the offices, restaurants, and movie theaters people will be spending time in, regardless of the weather outside.

It's also important to consider the way humans' behavior changes with each season. Though many viruses tend to thrive in winter months, most individuals tend to stay in-doors and at home to avoid the cold weather. Thisisolation could slow the spread of infection, but the indoor circulation of germs and bacteria could also result in a weaken immune system. On the other hand, people tend to spend more time outdoors and in public spaces during the warm-weather months. The increase in social interaction could lead to a spike in transmission; but will the summer climate lower the risks of infections? At this point, we'll have to wait and see.

"Weather and climate can only explain part of the transmission, the other factors are nonenvironmental social distancing, washing hands, covering your cough, staying home when you are sick and these factors are probably the most important in a pandemic," Jesse Bell, a climate health expert at the University of Nebraska, told BuzzFeed. "Understanding climate and weather will only tell you when the environmental conditions are optimal for the spread of the virus."

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Experts Warn COVID-19 May Not Disappear During Warm-Weather Months - Complex

Want to Be an Instant Expert on Film Noir? Watch This Drama – The New York Times

Maybe its our gloomy national mood, the programming on Turner Classic Movies or the Columbia Noir series currently streaming on the Criterion Channel. But cinephiles have been chattering again about film noir, a category that is notoriously difficult to define but about which every movie lover has an opinion. Say youve heard the term, but you dont know quite what it means well, you have good company. Heres a quick rundown.

To rehash an old, inevitably circular set of arguments: Noir cant simply be a genre because it transcends genre. There are noir mysteries, noir melodramas, noir costume pictures, even noir-tinged westerns and science fiction. If noir is a style, its hallmarks might include terse dialogue, an interest in seamy aspects of human behavior and black-and-white cinematography. But a cataloging would have to embrace exceptions. (Leave Her to Heaven, the ne plus ultra of femme fatale movies, is in Technicolor.)

Noir might be a mood, but thats a bit amorphous, like Justice Potter Stewarts definition of hard-core pornography: I know it when I see it. Or perhaps noir was a temporary wave rooted in anxieties about World War IIs destabilization of American home life. According to this theory, noir-like work made later than the 1950s requires a separate category, the neo-noir. And if thats the case, the neo period has gone on longer than the original.

When the French critics Raymond Borde and tienne Chaumeton tilted at an early definition in 1955, they distinguished noirs from police procedurals, which, they said, explored crime from the outside, rather than within. In the early 1970s, Paul Schrader, a critic at the time and soon to be a screenwriter and director, took a stab at a survey, arguing that noir was primarily a matter of tone. Almost every critic has his own definition of film noir, he wrote, and a personal list of film titles and dates to back it up.

Im in favor of a big tent: If you can explain why its a noir, its a noir. But dont you dare name any movie with insufficient subtext, psychological complexity or an atmosphere that doesnt chill the soul.

There are many places you might start. The gimmes include Billy Wilders much-imitated Double Indemnity with Fred MacMurray as an insurance salesman who plots with Barbara Stanwyck to kill her husband and Edgar G. Ulmers B-movie Detour, with Tom Neal as a pianist who, while hitchhiking, ends up in a car with a dead man and then beholden to a merciless blackmailer (Ann Savage). The film epitomizes noirs grim sense of fate, and the cheap production values only add to the sordid ambience.

But there may be no better place for getting a handle on what noir is and isnt than Nicholas Rays In a Lonely Place, conveniently screening in Criterions Columbia Noir series. If you enjoy it, less-revived gems (like Pushover, with a post-Indemnity MacMurray embroiled in another lust-struck scheme) are nearby for the watching.

Stream it on the Criterion Channel or rent it on Amazon, FandangoNow, iTunes, Vudu and YouTube.

Even trying to categorize In a Lonely Place is tricky: It has elements of murder mystery, melodrama and Hollywood insider scoop. Yet it is certainly one of the most forthright films to deal with domestic abuse ever to come from a major production company, let alone in the early 1950s. Here is a movie so rough-minded, so willing to be unsympathetic that it opens with its protagonist, a screenwriter named Dixon Steele (Humphrey Bogart), threatening to get into a brawl with a stranger.

Dix takes home a hat-check woman from a movie-industry haunt, on the pretense that she can tell him about a novel that he is supposed to read and potentially adapt. Ray seals our identification with the antiheroic Dix by filming the woman, Mildred (Martha Stewart), staring straight at him and the camera as she regales him with the narrative. The Bogart who had already given moviegoers Sam Spade of The Maltese Falcon, Rick of Casablanca and Philip Marlowe of The Big Sleep still has a charm, but also a sneer and a temper.

Sometime after leaving Dixs, Mildred turns up dead in the early-morning hours. Laurel Gray even the name suggests shades of uncertainty a new neighbor who saw Dix from her balcony that night, gives the police information that helps with his alibi. Then Laurel (played by Gloria Grahame) falls in love with Dix, knowing theres a chance he may be a murderer.

Part of what makes In a Lonely Place a great example of noir is that it only sounds like a whodunit; the sleuthing, which occurs mainly offscreen, is tangential to the movies true subject.

Regardless of whether Dix is the wrong man for the murder, he is a wrong man in every other sense. The police have records of fights. An actress charged that he beat her up then changed her story and said she broke her nose running into a door. Under interrogation about Mildreds death, he engages in bizarre self-sabotage, responding flippantly to questions. His death wish extends to a capacity for road rage.

His success as an artist is far behind him: We hear that he hasnt written a hit since before the war (although Laurels presence in his life jump-starts his productivity). He seems fascinated by violence, even for a dramatist. At a dinner, he uses a detective, who served under him during the war, and his wife as players in a re-enactment of the crime, imagining it in more detail than the investigators, and with such vividness that, for a moment, it almost becomes real.

And as he tightens his psychological grip on Laurel, who runs the emotional gamut of infatuation, defensiveness and terror, In a Lonely Place builds to a devastating finale. There is even an acknowledgment that tidy answers cant bring peace to the relationship: Yesterday, this wouldve meant so much to us, Laurel says. Now it doesnt matter. It doesnt matter at all. (There may be some subtext here: Those eager to learn more about Grahames marriages to Ray and eventually to Rays son apparently a teenager when the two began their affair should listen to the You Must Remember This podcast on the actress.)

Any noir recommendation right now is going to be subject to the vagaries of streaming. To Schrader, Kiss Me Deadly (1955), which came late enough in the noir period to show self-consciousness and is suffused with atomic paranoia, was the masterpiece of the form. But its only on DVD. So is Nightmare Alley (1947), with Tyrone Power as a carnival worker who tries to make it as a mentalist and is brought low by aiming too high. Its being remade by Guillermo del Toro. Who said noir is over?

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Want to Be an Instant Expert on Film Noir? Watch This Drama - The New York Times

Eye Tracking Market (COVID-19 Impact) Outlooks 2020: Industry Analysis, Demand, Cost Structures, Growth rate and Forecasts to 2024 – Bandera County…

Eye Tracking Market

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Chapter 1 About the Industry1.1 Study Assumptions1.2 Scope of the Report

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Global Cell And Tissue Analysis Products Market with Coronavirus (Covid-19) Effect Analysis | likewise Industry is Booming Globaly with Key Players…

Cell And Tissue Analysis Products Market Global and outlook (2015 2025)

The report published onCell And Tissue Analysis Productsis a invaluable foundation of insightful data helpful for the decision-makers to form the business strategies related R&D investment, sales and growth, key trends, technological advancement, emerging market and more. The global Cell And Tissue Analysis Products market report includes key facts and figures data which helps its users to understand current scenario of the global market along with anticipated growth. The Cell And Tissue Analysis Products market report contains quantitative data such as global sales and revenue (USD Million) market size of different categories and sub categories such as regions, CAGR, market shares, revenue insights of market players, and others. The report also gives qualitative insights on the global Cell And Tissue Analysis Products market, that gives the exact outlook of the global as well as country level Cell And Tissue Analysis Products market.

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Major Companies Profiled in the Global Cell And Tissue Analysis Products Market are: Danaher, Luminex, EMD Millipore Corporation, PARTEC, GE Healthcare, Thermo Fisher Scientific, BD, Mindray, PerkinElmer, Miltenyi Biotec

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By Type the Cell And Tissue Analysis Products market is segmented into: Cell & Tissue Characterization Products, Bio specimens, Cell Separation Products

By Application the Cell And Tissue Analysis Products market is segmented into: Drug Discovery and Development, Stem Cell Research, Cell Biology, Other Research Practices

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Regions covered in this study are North America, Europe, Middle East & Africa, Latin America, and Asia Pacific. These regions are further analyzed based on the major countries in it. Countries analyzed in the scope of the report are the U.S., Canada, Germany, the UK, France, Spain, Italy, China, India, Japan, South Korea, Southeast Asia countries, Australia, Brazil, Mexico, GCC countries, South Africa, and Turkey among others.

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A detailed look at the Cell And Tissue Analysis Products Industry Changing business trends in the global Cell And Tissue Analysis Products market Detailed market bifurcation analysis at different level such as type, application, end user, Regions / countries Historical and forecast size of the Cell And Tissue Analysis Products market in terms of Revenue (USD Million) Recent industry development and market trends Competitive Landscape and player positioning analysis for the Cell And Tissue Analysis Products market Key Product Offerings by Major players and business strategies adopted Niche and Potential segments (ex. types, applications, and regions/countries) anticipated to observed promising growth Key challenges faced by operating players in the market space Analysis of major risks associated with the market operations

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Global Cell And Tissue Analysis Products Market with Coronavirus (Covid-19) Effect Analysis | likewise Industry is Booming Globaly with Key Players...

Increasing Demand for Cytokines Market to Substantially Surge the Revenues Through the COVID-19 Lockdown Phase and Forecast 2019 2029 Cole Reports -…

Cytokines are the cell signaling molecules which are secreted from the different body cells. Cytokines are the proteins which play an important role of messenger between cells and regulates various physiological and metabolic activities. Cytokines regulate various inflammatory responses, stimulate blood cells production, and stimulate tissue development & maintenance. Cytokine is a large family of the small protein which includes tumors necrosis factor, interleukins, interferons, lymphokines and chemokines. Cytokines are produced by a wide range of cells includes cells like macrophages, lymphocytes, T lymphocytes, endothelial cells, mast cells, fibroblasts, stromal cells and cells. Some cytokines developed into protein therapeutics to treat bone-related disorders, anemia, cancer, infection, multiple sclerosis. Cytokine is most commonly used in the research & development activities in the field of life sciences and drug development.

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Increasing research and development activities expected to favour the growth of the cytokines market. As well as growing life science research funding boost up the growth of the cytokines market. Increasing prevalence of diseases such as cancer and skin disorders expected to drive the growth of the cytokines market. The growing demand for regenerative medicines impels the growth of the cytokines market. The growing demand for cytokines for wound management and cancer therapeutics expected to drive the growth of the market. Growing funding for cancer-based research influencing the growth of cytokines market. Growing cell culture-based research activities and increasing demand for cytokines in stem cell biology are major factors expected to drive the growth of the cytokines market. Growing manufacturers investments in cell culture media production expected to favour the growth of the growth factors market over the forecast period. Growing strategic acquisition and merger activities among market players is the major trend in the cytokines market. The high cost of research-based cytokines products is the major factor expected to restrain the growth of the cytokines market.

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The global cytokines market is segmented on basis of product type, application, end users and region:

Cytokine is the large family of cytokines includes tumour necrosis factor-TNF, interleukins (IL), interferons, chemokines and other cytokines. Interleukins (IL) is the most commonly used cytokine and have large family. IL-1 family, IL-4 family, IL-6 family, IL-10 family are mostly commonly used interleukins family in the research. Cytokines are used in various field of the research such as dermatology, cancer, orthopedics, respiratory and other fields. Cytokines are used for the research application among end users such as pharmaceutical & biotechnology companies, contract research organizations and academic & research institutes.

North America expected to dominate the global cytokines market as increasing demand for cytokines products as increasing research and development activities. Europe expected to contribute second-highest revenue share in global cytokines market as a growing number of clinical trial and drug development activities. The Asia Pacific expected to grow with the highest growth rate in the cytokines market as an increasing number of pharmaceutical manufacturers, biotechnology companies and academic institutions in the Asia Pacific region. India, South Korea & China cytokines market expected to grow with a higher growth rate as growing research and development funding from the government. The Middle East & Africa cytokines market expected to grow with the lowest growth rate due to lack of research and development activities in the region.

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Some of the players operating in the global cytokines market are ,

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The 3 Most Important Things to Know About AbbVie’s Q1 Update – Motley Fool

AbbVie's (NYSE:ABBV) share price has been hit pretty hard this year by the COVID-19 pandemic. But its underlying business hasn't.

The big drugmaker announced its first-quarter results before the market opened on Friday. AbbVie easily beat Wall Street's revenue and earnings estimates, delivering strong year-over-year growth on its top and bottom lines. The company also maintained its full-year 2020 adjusted earnings outlook, projecting 8.1% year-over-year growth at the midpoint of its guidance range.

All of these items are significant. But here are the three most important things to know about AbbVie's Q1 update.

Image source: Getty Images.

When Humira first began to face biosimilar competition in Europe, some might have thought the end was nigh for the world's best-selling drug. International sales for Humira plummeted throughout 2019. And international sales for the immunology drug continued to fall in the first quarter of 2020, down 14.9% year over year.

But the big picture for Humira continues to look pretty good. AbbVie reported total Q1 sales for the drug of $4.7 billion, up 5.8% year over year. This growth amounted to an extra $257 million for the company.

Although Humira continues to struggle in international markets, it's performing really well in the U.S. with sales jumping 13.7% year over year to nearly $3.7 billion. To be sure, it's only a matter of time before Humira's U.S. sales begin to sink. The drug faces biosimilar competition in the U.S. beginning in 2023. However, the longer Humira still hums along, the more time AbbVie has to get its post-Humira strategy fully into place.

That leads to the second important thing to know about AbbVie's Q1 update. The key drugs that are critical to the company's post-Humira future are gaining solid momentum.

First-quarter sales for AbbVie's blood cancer franchise soared 32.1% year over year. Imbruvica generated sales of $1.2 billion, a 20.6% increase over the prior-year period total. Venclexta is on track to reach blockbuster status with sales more than doubling in Q1 to $317 million.

Another blockbuster-to-be, immunology drug Skyrizi, raked in sales of $300 million after winning FDA approval in April 2019. Rinvoq, which was approved by the FDA in August 2019 for treating rheumatoid arthritis, made $86 million in Q1, up from $47 million in the previous quarter.

There's another component to AbbVie's plan for coping with the coming loss of exclusivity for Humira in the U.S. that's also critical -- the company's acquisition of Allergan (NYSE:AGN). AbbVie confirmed that it expects to close the transaction this month.

The company had already announced in March that it received final approval for the acquisition in Europe and that it had entered into a consent agreement with the U.S. Federal Trade Commission (FTC). The only news in AbbVie's Q1 update was that this consent decree was still subject to additional review and approval by the FTC's commissioners. However, AbbVie doesn't anticipate any roadblocks.

Assuming all goes as planned, AbbVie's next quarterly update will include sales from Allergan's blockbuster Botox franchise, fast-rising star Vraylar, and more. Humira will still be a major contributor to AbbVie, but after the second quarter, the immunology drug will no longer generate more than half of the company's total revenue.

With the COVID-19 pandemic wreaking havoc on the financial results for many companies, you might have expected that it would be one of the biggest stories in AbbVie's Q1 update. But it wasn't.

AbbVie actually benefited from the pandemic in Q1. The company stated that its revenue increased by 240 basis points because of stocking up related to the COVID-19 outbreak.

It just might benefit even more in the future. The drugmaker is evaluating Imbruvica in a phase 2 clinical study in treating COVID-19 patients. AbbVie is also working with global health authorities to determine if HIV drug Kaletra could be effective in treating COVID-19.

The big pharma stock could still be affected in the future to some extent by the pandemic, though. AbbVie acknowledged that there are uncertainties related to the COVID-19 outbreak. The company is assuming that stay-at-home orders will be gradually lifted beginning in May and that business will largely return to normal over the next few months for physicians' offices and hospitals. If those assumptions don't pan out, COVID-19 could be a much more important factor in AbbVie's quarterly updates later this year.

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The 3 Most Important Things to Know About AbbVie's Q1 Update - Motley Fool