Anime Anatomy: The 5 Weirdest Things About Luffy’s Body, Explained – CBR – Comic Book Resources

Ever wondered how Luffy's strange rubber body operates? Here's everything you need to know about the One Piece captain's unique physiology.

As captain ofOne Piece's famous Straw Hat pirates, Monkey D. Luffy's ambitiousness can lead to him being impulsive at times. But he's still a genius when it comes to combat; possessing the fighting prowess to always get himself and his crew out of most of the sticky situations they find themselves in. This is, in part, thanks to oneof the major staples introduced early on in the series:Devil Fruits, which, when consumed, grant users like Luffy unique abilities.

As a child, Luffy ate the most common of the three types of Devil Fruit -- the Paramecia. The Paramecia fruit encompasses a wide array of abilities and differs from the Zoan and Logia type fruits in that they do not allow their user to transform into an animal or natural element. More specifically, Luffy ate the Gomu Gomu no Mi or the Gum-Gum Fruit, transforming him into a rubber human, akin to Marvel's Mister Fantastic. Here are some of the strangest effects this mysterious foodstuff had on his body.

RELATED:One Piece's Luffy Could Beat Dragon Ball's Goku (Without Super Saiyan)

The Gomu Gomu no Mi fruit that Luffy ate effectively gave his body the quality of elasticity. The human equivalent of a rubber band, the pirate captain canstretch his limbs to extraordinary lengths, allowing him to reach far-off distances while simultaneously increasing his effective attack range.

And like a rubber band being stretched prior tobeing flung, Luffy's limbs are capable of storing energy to effectively bolstering his attack power. Luffy's body does have a limit to how far it can stretch, however; with seriescreatorEiichiro Oda comically declaring it to be "72 Gomu Gomus," which is quite a distance.

ThroughoutOne Piece, Luffy's body has displayed numerous natural immunitiesand feats of endurance. Luffy is immune to blunt force as his elastic body dulls the impact of bullets, cannons and hand-to-hand strikes, and such attacksbounce right off of him. Luffy can also endure falls from heights that would prove fatal to normal humans anddisplaylittle to no signs of damage from the impact. He's even proven to be resistant to lightning, evidenced during his fight against theGod of Skypeia, Enel, who ate the Goro Goro no Mi allowing him to control the element.

Despite these advantages Luffy is not immortal. Though immune to lightning, he can be damaged by other elements such as fire or ice, attacks involving cutting or stabbing and Haki-infused attacks. Another weaknessdisplayed early on in One Piece isthatLuffy's stretched limbs must be recalled after launching an attack, and if unprepared, can leave Luffy defenseless during the recall period.

Enemiescan exploit this openingand launch a counterattack, or in some cases even use the outstretched limb as a means of transportation, running along an outstretched arm or leg in order to close the distance between themselves and Luffy.

RELATED:Vegapunk: Who is One Pieces Mysterious, Devil Fruit Scientist?

Luffy's interior organs also behave like rubber and exhibit a balloon-like quality of elasticity. As a result, Luffy's stomach is larger than the average human and as such he requires large amounts of food to sustain activity, explaining his ravenous appetite. Luffy's blood cells are also made of rubber, a property he exploitsto accelerate the blood flow throughout his body when using Gear Second.

In this mode, he stretches these cells and releases the energy stored in them to accelerate his blood flow, vastly increasing his speed and attack power. The elastic property of his bones, other the other hand, is what allows him to inflate them when using Gear Third and Gear Fourth, allowing him to preposterously enhance the size of his body and limbs.

Luffy is capable of further bolstering his offensive and defensive prowess through the application of Busoshoku or Armament Haki. He has also displayed an ability to ignite and apply flames to his attacks through the technique. However, when outside of Gear Fourth, the body part to which Haki is applied loses someof the aforementioned properties of rubber, evidenced his battle against Don Chinjao when Luffy's fist discharges electricity while using Gomu Gomu no Thor Elephant Gun inEpisode 649,"The Fierce Battle Coming to the End - Lucy vs. Chinjao." This is despite the already established fact that his rubber body does not conduct electricity.

RELATED:Every Anime Series and Film Delayed by COVID-19

Despite the enormous power that Devil Fruits grant, consumption comes at the cost of losing the ability to swim. Devil Fruit users become like sinking stones when submerged in water and Luffy is no exception. For pirates constantly at sea, this side effect can be quite a nuisance -- and not just in the case of ocean traversal.

Introducedby then Captain Smoker inEpisode 53, "The Legend Has Begun! Head to the Grand Line," Seastone is a special substance that emits the same energy as the sea, allowing even normal soldiers to completely immobilize Devil Fruit users. Despite this weakness, Luffy's body retains its rubber qualities and elasticity even when exposed to the sea, evidenced by Nojiko's successful extension of Luffy's neck despite his body being submerged in waterinEpisode 39,"Luffy Drowning! Zoro vs Octopus Hatchan!"

When the butt of a joke or the target of Nami's rage, it appears that Luffy's normal immunity to blunt force is seemingly nullified, as he's suffered numerous beat downs at the hands of the Straw Hat pirates' navigator. We can chalk this one up to cartoon silliness, though.

KEEP READING:One Piece: The Spade Pirates, Ace's First Powerful Crew, Explained

Justice League Odyssey Just Killed Off DC's Deadliest Batman

Brandon is a Film and Media Studies Major at Lafayette College, and is now an Anime and Manga Feature writer for Valnet, Inc.

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Anime Anatomy: The 5 Weirdest Things About Luffy's Body, Explained - CBR - Comic Book Resources

Gotham Anatomy: The 5 Weirdest Things About Nightwing’s Body – CBR – Comic Book Resources

Dick Grayson is known by many names -- Robin, Nightwing, Ric. Regardless of the name, one thing remains the same: his incredible body. Grayson lacks superpowers in the traditional sense, but he has trained his physical form to the peak levels of human capabilities to turn him into a hero who can inspire fear in demons like Trigon.

However, what makes Grayson so unique is how his body changed over time. When Dick was introduced, he was 12-years-old, and as time has passed, he's grown into an impressive hero. Given that he is one of the few superheroes fans have grown up with, many comic writers and artists alike decided to explore how growing up a superhero affected Grayson, as well as his body.

RELATED:How Did Superman Inspire Nightwing's Superhero Identity?

Grayson's childhood was the circus. Before meeting Batman, Grayson had already trained his body to be part of the Flying Grayson performance act. However, as with all things, Grayson didn't just become a competent acrobat. He became one of the best. According to Haly's Circus, where the Flying Graysons performed, Dick as a child became one of three people in the DC Universe to perform a quadruple somersault. Even Batman can't do that. Tim Drake figured out that Nightwing was Robin after observing Nightwing perform the move.

However, considering Grayson could do this at the age of twelve, Dick would be on-par with real-life Olympians before entering puberty. In real life, the quadruple somersault is considered one of the most dangerous flips in gymnastics history. It remained impossible to perform until 1982 by then 17-year-old gymnast Miguel Vazquez. This means that even before training to be Robin, Dick Grayson was an Olympian. However, after training with Batman, Grayson became arguably the world's greatest acrobat, period.

The average person can't go three days without sleep before they start to hallucinate. Dick Grayson heard that and decided to just push himself to the absolute limits of human capabilities. Dick Grayson has been out on patrol for at least four days without sleeping and has done it with some regularity at that. While this might not seem like a dramatic feat on its own, consider that Dick Grayson is a normal human, without training or any alien physiology. This means that Grayson is able to stay awake and resist hallucinations caused by a lack of sleep for four days while still going out and being a superhero.

This is just one of many peak-human feats that Grayson can do. He can hold his breath for seven minutes without straining himself. His body is naturally resistant to toxins and poisons. All of this equals a person who is not superhuman but is still peak human. And all of that is thanks to personal training.

At 6' and 175 lbs, Dick Graysonhas a perfectly averagebuild for an adult male. By comparison, Chris Duffin, the first power-lifter to squat and deadlift over 1000 lbs for reps, is way, way bigger than that. Many powerlifters who have muscles strong enough to lift such huge amounts of weight are far bigger than Dick. Yet, Dick can lift over 1000 lbs of a burning building, if needed, to protect those left trapped inside.

Dick's most remarkable physical features are his incredibly lean yet powerful muscles. Grayson has comparable strength to Batman, yet weighs almost forty pounds less than the Caped Crusader. It may be surprising that he is this physically powerful, yet so light-weight. Or, at least, it would, if we didn't take into account that gymnasts on a regular basis are able to bend their body to best support their own weight and the various strains put upon their bodies. This natural talent, combined with Batman's continuous training, have honed Dick's physical capabilities to previously impossible levels of power output.

RELATED:Scott Snyder Shares Details On His Nightwing Comic Pitch

Dick Grayson has no superpowers, yet can still dodge bullets fired at close range. He's even able to dodge a bullet fired from a sniper rifle right for him. However, while these feats sound like incredible demonstrations of Dick's speed, the reality is far different. Dick Grayson isn't super fast, but rather has super-fast reflexes. The human body cannot dodge a bullet once the bullet is dislodged from its gun, meaning Dick would have to start reacting to a bullet before it leaves the chamber. This means Grayson has incredibly trained reflexes that allow him to maneuver around the calculated trajectory of a bullet.

This, again, is no doubt something he developed as a kid that only was heightened through training with Batman. His reaction time is so incredible that he can react to bullets being fired even before the sound of the bullet being fired reaches his ears. Some sniper bullets can travel almost four times the speed of sound, which means that, by concentrating on his other senses, Dick could maneuver his way around a bullet fast enough to evade it.

Many artists, such as Nicola Scott, have given extra attention to Dick Grayson's butt and hips. And many have drawn Dick posing in postures that deliberately give his rear prominence. While many artists might see this as a bit of fan-service, Dick's strong glutes actually explain every ambiguity about Dick Grayson that we've seen so far.

Strong gluteus minimus, medius, and maximus muscles can prevent injury, increase core strength, as well as increase sprinting and jumping capabilities. Dick's biceps and abs might help him pick up 1000 lbs of a burning building, but his butt might be the key to how he can hold the building up long enough for civilians to escape.

Dick Grayson is actually faster than Batman, able to reach up to 30 MPH while sprinting. Such an ability is impossible for someone without incredibly strong glutes. On top of that, many of Grayson's positions, especially his most flexible ones, would causehim muscle tears if not for his strong gluteus muscles keeping his lower-half in check. In fact, even the key to his incredible acrobatic abilities can be traced to his incredible butt muscles. What at first appears to just be artwork produced by thirsty fans is ultimately the potential key to Nightwing's incredible strength and power.

KEEP READING:Nightwing: Why Jason Todd STOLE Dick Grayson's Identity

Star Wars: The Galaxys Strongest Sith Was WAY Less Powerful Than You Think

Earned my MFA from Fairleigh Dickinson University. Written for The Mary Sue, ScreenRant, The Anime Feminist, The Gamer, and Vocal. Lifelong lover of comics, anime, and weird films. Loves different varieties of coffee.

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Gotham Anatomy: The 5 Weirdest Things About Nightwing's Body - CBR - Comic Book Resources

Greys Anatomys DeLucas bipolar confirmed in heart-breaking Station 19 episode – The Sun

GREY's Anatomy's Andrew DeLuca's bipolar will be confirmed in a heart-wrenching crossover episode with Station 19.

The American-action drama based at the Seattle fire station confirmed the surgeon's diagnosis just weeks after Grey's Anatomy season 16 ended early.

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The latest series of the medical drama has seen Andrew struggle mentally.

Inepisode 18, Give a Little Bit, DeLuca discovered that one of his patients was a victim of human trafficking, but fearing for his wellbeing, none of his colleagues listened to him.

The original plan for the show was to go back to this plot during the final episodes of the series, but that was put on pause.

Instead, they managed to finish filming the season in station 19, Andrew's sister Carina DeLuca (Stefania Spampinato), appeared in the most recent spin-off episode and told Maya Bishop the bad news.

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She uttered: "My dad has bipolar 1, and my sweet baby brother has inherited it."

Showrunner Kristia Vernoff, who is the boss of both shows, previously suggested that Andrew's cut storyline for Grey's Anatomyseason 16, could still take place in the next series.

She explained: "We had an episode where [the girl] comes back, and I am really sad that we can't air that episode this season because it felt important to offer that kind of hope to people who are living that experience."

The 48-year-old added: "I may still complete that story next season."

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During an Instagram live chat with Variety, another popular character from Grey's Anatomy and saysher character Doctor Meredith"begging for love isnt empowering."

She told Variety during a chat on Instagram live: "I have a different perspective, and maybe people see the beginning of the show as more empowering than I did. "But that, 'Pick me, choose me, love me' (line); I was like, 'Why am I begging a man to love me?' To me, that's not empowering."

The scene took place in season 2 episode 5, Bring the Pain, which aired back in 2005 and saw Meredith try to convince Derek Shepherd (Patrick Dempsey) to leave his wife Addison Montgomery (Kate Walsh).

She boldly declared her love and asked him to "pick me, choose me, love me."

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Greys Anatomys DeLucas bipolar confirmed in heart-breaking Station 19 episode - The Sun

Greys Anatomy season 17 will feature unchartered storyline – Micky News

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Greys Anatomy season 17 will feature unchartered storyline - Micky News

Debbie Allen of ‘Grey’s Anatomy’ Shares Photo with Sister Phylicia Rashad and Mom on Mother’s Day – AmoMama

Debbie Allen paid tribute to her mother, Vivian on Mother's Day by giving credit to her forher success as a creativeartist. She also shared photos featuring her equally successful sister, Phylicia Rashad, and revealed the shared beauty they possess.

Sisters Debbie Allen and Phylicia Rashad are legends in the industry thanks to their mother, Vivian Ayers Allen who never stopped believing in them.It is for this reason that Debbie acknowledged their mothers role in their success in her Mothers Day post last weekend.

Debbie was grateful to Vivian when she shared images of them with her sister, Phylicia. The first of two was a recent pic while the second was a black-and-white throwback revealing the beauty that binds them and their uncanny resemblance.

Debbies sweet message was a toast to Vivians commitment and faith in her daughters.

Youve always made us believe that we were part of a universe that welcomed us, wanted our creativity and was waiting for us to do something good. And so weve been doing that forever.

Her message ended with the words, Thank you for your light, Mommy.

Bound by their shared passion for the arts, Debbie and Phylicia grew up embracing their talents in spite of the obstacles posed by racial segregation which forced them to uproot from the US to Mexico City.

Phylicia told Oprah in 2017 that their mother made sure they would not be scarred by this ignorance.

So, when there was someplace we wanted to go and we couldnt go because of segregation, she would say, We wont be able to go there because its a private club and were not members of that club, the The Cosby Show star explained.

Vivian, a Pulitzer Prize-nominated poet, became the main caregiver of her family after she divorced her husband in 1957. Phylicia was only 9 then and Debbie, 7.

As the head of her brood which also included her two sons, Andrew Arthur and Hugh, Vivian encouraged her childrens creativity. She also made sure they learned to be independent by assigning them chores at home.

Its no surprise then that her daughters turned out to be very close andmasters of their craft.

We salute Vivian for raising such outstanding children and we wish her more years with them so she can continue to mother them in the best way she knows.

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Debbie Allen of 'Grey's Anatomy' Shares Photo with Sister Phylicia Rashad and Mom on Mother's Day - AmoMama

Virtually Explore The Mtter Museum, Repository of Medical/Anatomical Anomalies – Dread Central

One of the most fascinating and macabre repositories of medical and anatomical anomalies is The Mtter Museum of the College of Physicians of Philidelphia. According to their official website, The Mtter Museum helps the public appreciate the mysteries and beauty of the human body while understanding the history of diagnosis and treatment of disease.

While it may be months until it reopens to the public, you can now join Curator Anna Dhody on a virtual tour of the Mtter Museum from the safety of your home by pressing Play at the top of the article.

Tour highlights:0:05 Introduction and History1:40 Hyrtl Skull Collection4:04 Our Finest Clothing: A Layered History of Our Skin5:15 Dermatological Wax Models6:51 The Soap Lady10:00 Giant Megacolon12:10 Cast and Livers of Chang and Eng Bunker15:05 Mtter American Giant17:12 Achondroplastic Dwarf18:45 Harry Eastlack and Carol Orzel21:36 Albert Einsteins Brain24:06 Conclusion24:33 Blooper!

You can also examine many of the museums most chilling artifacts in virtual 360. Check out conjoined twins, a coal miners lung, a human horn, the brain of a killer, a 74-pound ovarian cyst, and many more bizarre artifacts of human anatomy, HERE.

What do you think of the virtual tour and specimens from The Mtter Museum? Let us know in the comments below or onFacebook,Twitter, orInstagram! You can also carry on the convo with me personally on Twitter@josh_millican.

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Virtually Explore The Mtter Museum, Repository of Medical/Anatomical Anomalies - Dread Central

5 Reasons Why ER Is The Definitive Medical Drama (& 5 Why It’s Grey’s Anatomy) – Screen Rant

ERandGrey's Anatomywere on the air for about four years at the same time. For four years, medical drama fans could watch Chicago on NBC and then switch to Seattle on ABC. Many medical drama fans have and continue to enjoy more than one medical show on television.

RELATED:10 Best Medical Dramas (Aside From Grey's Anatomy), Ranked

This year,Grey's Anatomyjust outpacedER's 15seasons by beginning its 16th. But sometimes it's quality over quantity. Which show, in the end, is the superior medical drama? It may be hard to decide, but here are a few reasons to love one over the other.

While Dr. McDreamy may have defined a great deal of a show named after his eventual wife (Meredith Grey), Patrick Dempsey still spent agood deal of time onGrey's Anatomynot doing medical things. He lived in a trailer, wanted to marry Meredith, and he hung out at Joe's Bar.

Clooney's Dr. Doug Ross, on the other hand, partied off-screen (as seen in the pilot where he gets to work early to IV off a hangover) but was working with patients the majority of the time he was seen on the show. Even outside the emergency room, he was rescuing teenagers from floods (thus saving lives). The focus was on getting people healthy.

Grey's Anatomyhas often been compared to a soap opera, but lives are like soap operas. Just because a person has a job, or spends most of their time at work, doesn't mean that's all there is to them.ERspent most of its time actually in the ER (romances took place on that show too, but not to the extent they did onGrey's).

Grey's Anatomyhighlighted a lot of the doctors as people, rather than doctors. It's part of what made the show stand out from its first season, but it also helped to highlight the whole person, rather than only the bandages when it came to medicine.

It was always a surprise whenERhad an episode that spent a lot of time outside the emergency room. The drama happened at the intake desk, or in the staff room, or in triage.Grey's Anatomy, on the other hand,saw the doctors visiting Meredith's home, sharing apartments, or going to conferences. SometimesGrey'sforgot all about the medicine.

Fans got to know the ERcharacters by how they approached their patients, not how theytalked about them after hours over beers. The show was named after the place where the medicine happened, and thus that's where the action always took place.

While it is commendable thatERhad such a clear focus on the emergency department, medicine isn't all about sewing up blood and guts.

RELATED:Grey's Anatomy: The 10 Weirdest Operations Ever Seen In The Show

Sure, the doctors onGrey's Anatomyare training to be surgeons, but they also make trips to the pit, dermatology, and very frequently,the maternity ward. At Grey Sloan Hospital, viewers are treated to quite a broad view of medicine compared to what we see at County General.

Grey's Anatomymay have shown the different departments in the hospital, butERoffered a larger worldview on medicine. From the story of Kovac's losses in his home country of Croatia, to his trip to help save lives in Africa,ERhighlighted the different opportunities and struggles in treating patients in very different parts of the world.

Grey's Anatomysent its doctors around the country (even leading to plane crash once) but it didn't add to the show's reach, only its dramatics.

ERmay have seen interns like Dr. Carter rise up the ranks, butGrey's Anatomyfocused (in the beginning) solely on a group of interns and the different tasks and challenges required to become a full-fledged doctor and surgeon. For most of theERdoctors, fans took them as they were.

This is a side of medicine often discussed but rarely explored on TV. It takes years of school and training to be successful andGrey's Anatomywanted to explore that struggle, not just thefight to save lives.

Very few hospitals seen in films and on television look very much like the hospitals that regular peoplevisit every day. While the design varies widely in the real world, more people have seen rooms similar to those seen atCounty General, than the clean, shiny, and high tech halls of Grey Sloan.ERhad the more realistic set, no questions asked.

Medical dramas, in general, don't get terribly close to the real experiences of practicing medicine, butERgot a little bit closer to the look.

Bailey has been onGrey's Anatomysince its first season and there's a reason.Besides the brilliant acting fromChandra Wilson,Bailey has always been the voice of truth on the show. Being a doctor is hard. It takes time and sacrifice, and Bailey has never been afraid to say so. While ER doctors hung around for quite a few seasons, the series finale left barely anyone from the original cast.

RELATED:Grey's Anatomy: The 5 Best (& 5 Worst) Doctors On Call

She has never been afraid to say it loudly and clearly to anyone who can hear. She acknowledges a truth that often gets missed when programs normally cure patients in less than the one-hour time slot.

WhileGrey's Anatomyhas had more than its fair share of catastrophes (see bombings, sinkings, shootings, building collapses, plane crashes),ERhighlighted the chaos that existed in the emergency room on a regular basis.ER, unlike Grey's,didn't need the world around them to collapse for it to feel that way.

Every new patient could be its own disaster and it didn't take the city imploding on itself to made medicine a case of life or death. And for many patients who show up for ER medical attention, it can certainly feel like life or death.

It may seem like a dramatic license, but many surgeons, in fact, listen to music in the operating room (surgery can take quite a long time, after all). In that sense,Grey's Anatomy could be a little more realistic thanER.

It certainly makes for compelling television, but it's also a little bit of truth that the medical community has confirmed to their friends and loved ones. Sometimes music is its own medicine.

NEXT:Grey's Anatomy: 10 Of Derek's Scariest Surgeries

Next5 Best American Horror Story Characters (& 5 Worst)

Jessie Atkin holds an MFA in creative writing. She is a storyteller, writer, and reader. She's a YA connoisseur, Star Wars enthusiast, Harry Potter fanatic, Mets devotee, and trivia aficionado.

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5 Reasons Why ER Is The Definitive Medical Drama (& 5 Why It's Grey's Anatomy) - Screen Rant

Repurposed drug helps obese mice lose weight, improve metabolic function – National Institute on Aging

An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and reversed metabolic damage in obese middle-aged mice of both sexes. The international study was led by researchers at the National Institute on Aging (NIA), part of the National Institutes of Health . The results were published online in the journal Cell Metabolism on May 14.

The scientific team studied groups of 9-month-old lab mice who had been fed a high-fat diet for 12 weeks. As expected, this diet made the mice overweight and they started to show signs of pre-diabetes-like metabolic problems, such as insulin resistance and elevated fasting blood sugar levels. Next, the scientists divided these mice into four groups to be fed four different diets for an additional 12 weeks: a standard diet alone, a high-fat diet alone, a high-fat diet with a low amount of disulfiram, or a high-fat diet with a higher amount of disulfiram. As expected, the mice who stayed on the high-fat diet alone continued to gain weight and show metabolic problems. Mice who switched to standard diet alone gradually saw their body weight, fat composition and blood sugar levels return to normal.

The mice in the remaining two groups, with either a low or high dose of disulfiram added to their still-fatty food, showed a dramatic decrease in their weight and related metabolic damage. Mice on the high disulfiram dose lost as much as 40% of their body weight in just four weeks, effectively normalizing their weight to that of obese mice who were switched back to standard diet. Mice in either disulfiram dose diet group became leaner and showed significant improvement in blood glucose levels on par with the mice who were returned to standard diet. Disulfiram treatment, which has few harmful side effects in humans, also appeared to protect the pancreas and liver from damage caused by pre-diabetic type metabolic changes and fat build up usually caused by eating a high-fat diet.

The NIA scientists, Michel Bernier, Ph.D., and Rafael de Cabo, Ph.D., collaborate frequently with researchers at NIH and beyond on studies into how changes in dietary patterns like intermittent fasting could lead to cognitive and physical health benefits. They first became interested in disulfiram after reading about the benefits this class of drug has shown in treating type 2 diabetes in rats, coupled with the growing interest in repurposing drugs that may also improve healthy aging.

When we first went down this path, we did not know what to expect, but once we started to see data showing dramatic weight loss and leaner body mass in the mice, we turned to each other and couldnt quite believe our eyes, Bernier said.

According to studys research team, the key to the positive results seem to stem from disulfirams anti-inflammatory properties, which helped the mice avoid imbalances in fasting glucose and protected them from the damage of fatty diet and weight gain while improving metabolic efficiency. Both groups of obese mice (control and disulfiram) were not subjected to any form of exercise, nor did they demonstrate noticeable spontaneous behavioral changes. Based on the evidence they observed, the researchers believe the beneficial results of disulfiram stem solely from the drug. They did not observe any negative side effects from disulfiram in the mice.

The research team stresses that these results are based on animal studies, and they cannot be extrapolated to any potential benefits for human at this point. It is recommended that disulfiram not be used off-label for weight management outside of the context of clinical trials. Still, given the findings, they are planning future steps for studying disulfirams potential, including a controlled clinical study to test if it could help individuals with morbid obesity lose weight, as well as deeper investigation into the drugs molecular mechanisms and potential for combining with other therapeutic interventions.

The research was supported by NIA through its intramural research program, NIA grants AG031782 and AG038072, in collaboration with colleagues from the National Institute of Alcohol Abuse and Alcoholism, Yale University, Albert Einstein College of Medicine, Korea Research Institute of Bioscience and Biotechnology, and University of Sydney, Australia.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.

Reference:

Bernier et al. Disulfiram prevents and treats diet-induced obesity and related co-morbidities in mice. Cell Metabolism. 2020 May 14. doi: /10.1016/j.cmet.2020.04.019

About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people. Learn more about age-related cognitive change and neurodegenerative diseases via NIAs Alzheimer's and related Dementias Education and Referral (ADEAR) Center website. For information about a broad range of aging topics, visit the main NIA website and stay connected.

About the National Institute on Alcohol Abuse and Alcoholism (NIAAA): The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, diagnosis, prevention, and treatment of alcohol use disorder. NIAAA also disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at https://www.niaaa.nih.gov/.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit https://www.nih.gov/.

NIH...Turning Discovery Into Health

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Repurposed drug helps obese mice lose weight, improve metabolic function - National Institute on Aging

The open office will survive – Employee Benefit News

By Sarah Green Carmichael

When I think back to pre-coronavirus office life, it almost seems designed to spread germs.

Theres the hour-long commute on the crowded train; the steady flow of fingers poking at elevator buttons and coffee machines; and our open rows of desks with nary a cube wall to prevent a surprise sneeze from traveling across the room. Its perhaps not surprising that a 2013 study found that germs can spread from one persons hand to half of office surfaces in just four hours.

We clearly need to do better in the post-lockdown future. But how?

The essential organizations that remained open during the coronavirus shutdowns offer some clues. They reduced crowding by staggering shifts, asking some employees to work from home and designating corridors for one-way travel. They installed clear plastic barriers at cash registers and reception desks. Some implemented temperature checks, though those arent foolproof, since asymptomatic people can spread the virus and even many hospitalized COVID-19 patients never develop a fever.

You might be wondering if well see major architectural changes too some have even predicted the end of open offices. But this isnt likely. Such redesigns are expensive and intrusive, says Jennifer Kaufmann-Buhler, an assistant professor at Purdue University and author of the forthcoming Open Plan: A Design History of the American Office. In the midst of a severe recession, most firms cant afford to splash out for new spaces. Even if well be social distancing for two more years, a big office remodel probably doesnt make much financial sense.

Human behavior is easier to change than architecture. And open offices, with their flexible spaces, allow for very different behaviors. This adaptability is why the open office has resisted all attempts to kill it, and also why it is surprisingly well-suited to this moment of change.

Germophobes worried about open offices long before the coronavirus pandemic. Studies conducted in Europe linked open-plan offices with reduced well-being and higher use of sick days, though its not clear whether this is because germs spread more easily, or because being always on display reduces productivity and increases stress.

Critics also like to point out that open offices are even bad at the one thing theyre supposed to do well: foster collaboration. Harvards Ethan Bernstein and Ben Waber of Humanyze studied companies that switched to open floor plans and found that face-to-face conversations fell by 70% after the change.

Nevertheless, these wide open spaces have persisted.

[The open office] has really been with us since the 1960s, and some would say even earlier than that, says Kaufmann-Buhler. The earliest iterations go back to the late 19th century and look much like they do today: rows of desks in large, open spaces.

Open plans are never going away, says Kaufmann-Buhler, though theyve been declared dead so many times. Every time she sees a headline announcing as much, she thinks to herself, Ah, the open plan is dead, long live the open plan.

Thats because its a design thats extremely cost effective. Its not just the lack of walls, or the number of people you can pack in. Its that private offices require more of everything doors, ventilation ducts, energy consumption. Plus, open workspaces let in more light, and allow you to easily make eye contact with colleagues something I find I miss about the Bloomberg offices these days.

And open plans are adaptable, whether its a Mad Men-era secretarial pool or a modern-day coworking space. You can easily add (or subtract) workers, and rearrange desks and other equipment as needed. In fact, that flexibility is what companies are going to be relying on now, as they push desks further apart, add panels or partitions and commandeer large communal spaces, like conference rooms, for other purposes.

Thats not to say there are no physical upgrades that are worthwhile. Those lucky companies with deep pockets could invest in touchless technology, like motion-sensor doors, light switches and bathroom faucets, to limit the common surfaces employees interact with.

If your HVAC system is getting a bit long in the tooth, this would be a great time to invest in a newer system that offers air filtration. Older [systems] are woefully out of date and inadequate in terms of protective elements, says Kaufmann-Buhler. Some of them recirculate air too much and run the risk of spreading germs.

Because major upgrades are likely to be out of reach for most companies, many firms will rely on behavior change which can be quite powerful. In that 2013 study that showed germs spreading to half the office by lunchtime, simple interventions like washing hands, using hand sanitizer and providing employees with free cleaning wipes slashed peoples risk of getting sick from 40-90% to less than 10%.

And companies will certainly be beefing up their cleaning schedules, particularly in common areas like bathrooms, break rooms and elevators. This alone would be a major change. As it is, Offices are kind of gross places, says Kaufmann-Buhler. They dont seem that dirty in the first place, so they tend to get only lightly cleaned by the overworked and underpaid contractors most firms hire.

Firms in skyscrapers will also have to figure out ways to minimize contact around doors and elevators. The easiest solution may be to employ doormen and elevator attendants, and stagger working hours to avoid long queues.

Organizations that have served food, free or otherwise, will likely reconsider how they do so if they keep serving it at all. For one thing, in the middle of a recession (or even a depression) with perhaps 20% unemployment, companies may no longer feel they need to offer costly perks like free meals. (Note to my employer: This is not a recommendation! I dearly miss the Bloomberg food.) At the very least, company cafeterias will likely ask employees to stagger their lunch breaks to avoid crowding. Instead of eating off an open deli tray with friends, youll probably be taking a boxed lunch back to your desk to eat six feet away from anyone else.

And yet it is inescapable that prolonged, indoor proximity is the primary way this virus is spreading and such contact is inescapable if people return to work, regardless of the precautions organizations take. Thats why many firms will rightly encourage employees to keep working from home and visit the office only when absolutely necessary.

Even then, instead of dropping in whenever you like, your visits will be scheduled. Some organizations are dividing their staffs into two teams, which take turns coming into the office on alternate weeks or fortnights. (Given how long the virus can survive on surfaces, its probably not a good idea to ask employees to come in on alternate days. Give the germs at least a weekend to degrade.)

Swabs of everyday items routinely find that its the things were always touching with our hands that are the dirtiest that means keyboards, phones, mice and trackpads. This may portend the end of hotdesking (in which employees have no permanent workstation, but simply sit wherever they like) and a major revamp of hoteling (in which employees share a specific workstation on a rotating, scheduled basis).

And forget holding large face-to-face meetings. Those will still have to take place via videoconference.

All of this is going to have a huge impact on the ways people interact with each other and the way people think about work, Kaufmann-Buhler says.

In other words, if youve been missing your office these past eight weeks, that feeling of dislocation may not dissipate even if you return to HQ. No matter what your office looks like, it will feel very different.

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The open office will survive - Employee Benefit News