Summary: A new study highlights a significant link between prolonged use of certain progestogen hormone drugs and an increased risk of developing intracranial meningioma, a type of brain tumor. Researchers analyzed data from 18,061 women who underwent surgery for intracranial meningioma, comparing their progestogen use to 90,305 controls.
The study found that prolonged use of specific progestogens, including medrogestone, medroxyprogesterone acetate, and promegestone, is associated with an elevated risk of requiring surgery for meningioma. This research underscores the urgent need for further studies to understand this risk fully, especially given the widespread use of these hormones in treating conditions like endometriosis and as part of contraceptive methods.
Key Facts:
Source: BMJ
Prolonged use of certain progestogen hormone drugs is associated with an increased risk of developing a type of brain tumour known as an intracranial meningioma, finds a study from France published byThe BMJtoday.
The researchers say this study is the first to assess the risk associated with progestogens used by millions of women worldwide, and further studies are urgently needed to gain a better understanding of this risk.
Progestogens are similar to the natural hormone progesterone, which are widely used for gynaecological conditions such as endometriosis and polycystic ovary syndrome, and in menopausal hormone therapy and contraceptives.
Meningiomas are mostly non-cancerous tumours in the layers of tissue (meninges) that cover the brain and spinal cord. Factors such as older age, female sex, and exposure to three high-dose progestogens (nomegestrol, chlormadinone, and cyproterone acetate) are already known to increase the risk of meningioma.
But there are many other progestogens for which the risk of meningioma associated with their use has not been estimated individually.
To address this knowledge gap, researchers set out to evaluate the real life risk of intracranial meningioma requiring surgery in women associated with use of several progestogens with different routes of administration.
They used data from the French national health data system (SNDS) for 18,061 women (average age 58) who underwent intracranial meningioma surgery from 2009-18.
Each case was matched to five control women without intracranial meningioma (total 90,305) by year of birth and area of residence.
The progestogens examined were progesterone, hydroxyprogesterone, dydrogesterone, medrogestone, medroxyprogesterone acetate, promegestone, dienogest, and levonorgestrel intrauterine systems.
For each progestogen, use was defined as at least one prescription in the year before hospital admission or within 3-5 years for levonorgestrel intrauterine systems.
Use of at least one of the three high-dose progestogens known to increase the risk of meningioma in the 3 years before hospital admission was also recorded to minimise bias.
After taking account of other potentially influential factors, prolonged use (a year or more) of medrogestone was associated with a 4.1-fold increased risk of intracranial meningioma requiring surgery.
Prolonged use of medroxyprogesterone acetate injection was associated with a 5.6-fold increased risk, and prolonged use of promegestone was linked to a 2.7-fold increased risk.
There appeared to be no such risk for less than one year of use of these progestogens.
As expected, there was also an excess risk of meningioma for women exposed to chlormadinone acetate, nomegestrol acetate, and cyproterone acetate, all of which are known to increase the risk of meningioma.
However, results showed no excess risk of meningioma for progesterone, dydrogesterone, or the widely used hormonal intrauterine systems, regardless of the dose of levonorgestrel they contained.
No conclusions could be drawn about dienogest or hydroxyprogesterone as the number of exposed individuals was too small.
This is an observational study so cant establish cause and effect, and the authors acknowledge that the SNDS database lacked information on all the clinical details and medical indications for which progestogens are prescribed. Nor were they able to account for genetic predisposition and exposure to high dose radiation.
However, they say, given that medroxyprogesterone acetate is estimated to be used for birth control by 74 million women worldwide, the number of attributable meningiomas may be potentially high.
Further studies using other sources of data are urgently needed to gain a better understanding of this risk, they conclude.
Author: BMJ Media Relations Source: BMJ Contact: BMJ Media Relations BMJ Image: The image is credited to Neuroscience News
Original Research: The findings will appear in The BMJ
The rest is here:
Prolonged Progestogen Use Linked to Brain Tumor Risk - Neuroscience News
- Unlocking Flow: The Neuroscience of Creative Bliss - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Revolutionizing Glioblastoma Treatment - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Decoding spontaneous thoughts from the brain via machine learning - EurekAlert - April 15th, 2024 [April 15th, 2024]
- Reducing Toxic AI Responses - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Advancing the neuroscience of human pregnancy - Nature.com - April 15th, 2024 [April 15th, 2024]
- Angela Bryan Awarded Hazel Barnes Prize | Psychology and Neuroscience - University of Colorado Boulder - April 15th, 2024 [April 15th, 2024]
- How Old Are You in Your Head? The Neuroscience of Subjective Age Reveals How to Stay Mentally Young - Inc. - April 15th, 2024 [April 15th, 2024]
- Biohaven Showcases Innovative Neuroscience Portfolio with 20 Presentations at the 2024 American Academy of ... - PR Newswire - April 15th, 2024 [April 15th, 2024]
- Those Who Use Willpower Deemed More Trustworthy - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- How Sex and Gender Shape Our Cognition - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- War's Toll on the Brain: Widespread PTSD and Anxiety Among Ukrainians - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Paints and Pesticides Linked to ALS Risk - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- AI STORIES: A New Vision for AI and Narratives - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Neuroscience Breakthrough Unveils How We Learn and Remember - SciTechDaily - April 15th, 2024 [April 15th, 2024]
- Pregnancy's Toll: Accelerated Aging in Young Mothers - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Learning and Memory Formation's Molecular Basis - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Acetaminophen in Pregnancy Not Linked to Autism, ADHD Risk - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Childhood Loneliness Linked to Later Psychosis - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Vigil Neuroscience, Inc. (NASDAQ:VIGL) Expected to Post Q1 2024 Earnings of ($0.58) Per Share - Defense World - March 29th, 2024 [March 29th, 2024]
- International Brain Research Organisation (IBRO) Diversity Grants 2024 Opportunity Desk - Opportunity Desk - March 29th, 2024 [March 29th, 2024]
- Hereditary Alzheimer's Transmitted Via Bone Marrow Transplants - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Household Chemicals Linked to Brain Health Risks - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Cheers to Longevity: Couples Who Drink Together, Live Longer - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Sleeplessness Makes You Feel Up To Ten Years Older - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Aging Brain Cells Have Prolonged Death Process - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Anxiety Drives Wishful Thinking to Risky Levels - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- The Genetic Secrets of Neuron Formation - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Vigil Neuroscience Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update - Yahoo Finance - March 29th, 2024 [March 29th, 2024]
- Big research, little time: Medical neuroscience student wins 3 Minute Thesis finals - Dal News - March 29th, 2024 [March 29th, 2024]
- The new NeuroAI - Nature.com - March 29th, 2024 [March 29th, 2024]
- Exploring Aphantasia: The Mind Without a Mental Picture - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Altered Brain pH Linked to Cognitive Disorders - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Emotion vs. Reason: Rethinking Decision-Making - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- DNA Damage and Inflammation Key to Memory Formation - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Embracing Neurodiversity: Beyond Stigma to Strength - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Devil in the Details: The Visual World of Prosopometamorphopsia - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Rockefeller Neuroscience Institute receives $2M grant for ultrasound drug addiction treatments - Health Imaging - March 29th, 2024 [March 29th, 2024]
- Empathy Begins in Infancy - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Mapping Brain Activity with Brain-Computer Interface Technology - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Want Better Mental Focus? Neuroscience Just Found This Simple, Joyful Activity Helps Your Brain Concentrate - Inc. - March 29th, 2024 [March 29th, 2024]
- The neuroscience of groove: Why certain rhythms make us want to dance - PsyPost - March 29th, 2024 [March 29th, 2024]
- High Rates of Suicidal Ideation in Rural Black Men - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Harmony in Chaos: How BPD Influences Music Tastes - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- WVU Rockefeller Neuroscience Institute receives $2M Grant - WDTV - March 29th, 2024 [March 29th, 2024]
- Study Links Diet, Diabetes, and Alzheimers - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Neuroscience and Society Series: Aligning Science with the Public's Values - The Hastings Center - March 29th, 2024 [March 29th, 2024]
- Hardwiring Your Brain: The Neuroscience Of Behaviour Change | TheHealthSite.com - TheHealthSite - March 29th, 2024 [March 29th, 2024]
- Refined Carb Intake's Effect on Facial Attractiveness - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Linking Childhood Adversity to Adult Mental Health - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Overnight neuronal plasticity and adaptation to emotional distress - Nature.com - March 11th, 2024 [March 11th, 2024]
- Less Obesity and Depression in NPD Individuals - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Unlocking Creative Flow: How the Brain Enters the Zone - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Self-Control, Not Impulsivity, Paves the Way to Power - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- 3D Maps Reveal Molecular Complexities of the Brain - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Loneliness Linked to Personality Disorders - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Gen Z's Climate Anxiety: A Call for Action and Hope - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Decoding Emotions: Beyond Senses in the Human Brain - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Brain Circuit Balances Speech and Breath - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Schizophrenia and Aging Share Brain Changes - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Monitoring Spinal Cord Activity During Surgery in Real-Time - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Scientists team up with jazz musicians to reveal the neuroscience of creative flow - PsyPost - March 11th, 2024 [March 11th, 2024]
- Peer Pressure Persists Through Adulthood - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Mary Bartlett Bunge, 92, Dies; Pioneer in Spinal Injury Treatment - The New York Times - March 11th, 2024 [March 11th, 2024]
- Rethinking Reminiscence: Theater's Ageism Dilemma Unveiled - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- PTSD: Virtual Reality and Magnetic Stimulation Provide Relief - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- The Partisan Morality Divide: When Politics Shapes Right and Wrong - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Biological Sciences Professor Terrence Sejnowski Wins Brain Prize - University of California San Diego - March 11th, 2024 [March 11th, 2024]
- Pioneering work in computational and theoretical neuroscience is awarded the world's largest brain research prize - afp.com - March 11th, 2024 [March 11th, 2024]
- Substance Abuse Beyond Dopamine and Impulsivity - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Pioneering work in computational and theoretical neuroscience is awarded the world's largest brain research prize - Business Wire - March 11th, 2024 [March 11th, 2024]
- Dal study of football players sheds light on how concussions affect the brain - Yahoo Canada Sports - March 11th, 2024 [March 11th, 2024]
- Hebrew University's Haim Sompolinsky awarded prestigious Brain Prize for pioneering neuroscience research - The Times of Israel - March 11th, 2024 [March 11th, 2024]
- Harvard neuroscientist Haim Sompolinsky awarded Brain Prize - EurekAlert - March 11th, 2024 [March 11th, 2024]
- Rhythm in the Brain: Music Exposure Influences Rhythmic Interpretation - Neuroscience News - March 11th, 2024 [March 11th, 2024]
- Physicist Haim Sompolinsky first Israeli to win largest brain science research prize - The Times of Israel - March 11th, 2024 [March 11th, 2024]
- Prestigious 2024 Brain Prize awarded to Hebrew University's Prof. Haim Sompolinsky by Lundbeck Foundation - EurekAlert - March 11th, 2024 [March 11th, 2024]
- Pioneering work in computational and theoretical neuroscience is awarded the world's largest brain research prize - EurekAlert - March 11th, 2024 [March 11th, 2024]
- Role of AI in Neuroscience Research and Understanding of the Human Brain - Medriva - February 13th, 2024 [February 13th, 2024]
- Healis selected to present at key biotechnology and neuroscience investor conferences in Amsterdam, New York, - EIN News - February 13th, 2024 [February 13th, 2024]
- Brain's Method for Preserving Cognition in Aging Revealed - Neuroscience News - February 13th, 2024 [February 13th, 2024]