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The Mid-Major Upset: An Anatomy – Last Word on Pro Basketball

Lets paint a picture for a moment. On a mid-November evening, youre a player on a power conference team preparing to play a game. Your coach has scheduled a game against a school you may not have even heard of before until tonight. They play in the WAC, or, is it the SWAC? You cant remember, but you know that you are expected to win this game. 40 minutes of basketball later, youre sitting in the locker room trying to figure out how your team became the victim of a mid-major upset.

Through the first 15 days of the college basketball season, there have been 15 instances of mid-major teams taking down teams from power conferences. Unless theyre of monumental value (looking at you Kentucky), they go largely unnoticed to the general public. However, for fans of both schools, there is either euphoria or heartbreak at the sound of the final buzzer. While it feels like these upsets come out of nowhere, there is a method to the madness. Whether its a hot night from the three-point line or crashing the boards hard, there are a few trends that have shown up in analyzing the box scores of those 15 upsets.

The first key to pulling off an upset seems to be a bit clich. Ever since the three-point line was adopted for the 1986-87 season, teams have been using it to their advantage. When three-point shots seem to start going in with ease, the NCAA continually pushes the line back. The most recent update was for the current season, as the rules committee pushed it to the FIBA line, which is 22 feet and 1.75 inches from the basket. Schools from mid-major conferences are often undersized when they match up with power conference schools. Thus, the best thing they can often do is keep the ball out of the paint and knock down three balls.

Across the 15 upsets this season, mid-major schools are shooting an average of 38 percent from behind the arc. Their power conference counterparts are shooting an average of just 28.8 percent. Its not as if the importance of the three-point shot is ignored either. After Connecticuts 96-87 defeat to Saint Josephs, Huskies head man Dan Hurley said, guarding the three-point shot was a point of emphasis all week at practice. Saint Bonaventure nailed 11 three-pointers in their defeat of Rutgers. Belmonts 15 made threes were the most ever made at Boston Colleges current arena. Nicholls State shot the three-ball 20 percentage points better than Pittsburgh in their victory over the Panthers.

In not defending well behind the arc, power conference teams open the door for mid-major teams to hang around. And, if they arent careful, that weakness just might have them leaving the gym with a loss. After all, the math tells that three points are more than two points.

How important are they? This is a question that is often heard when teams struggle to make their free throws towards the end of a close game. The free throw is supposed to be the easiest shot to make during a game. You are free of a defender being able to oppose your shot. If youre a mid-major school that can capitalize on your attempts from the free-throw line, then youve got a shot to pull off an upset.

While power conference teams have a slight edge in the average number of free-throw attempts in the 15 upsets, mid-major schools are making their attempts count. David shot an average of 77.8 percent from the charity stripe compared to Goliaths 68.3 percent clip in those 15 games. For example, Alabamas Kira Lewis Jr. missed both of his free-throw attempts with just 2.4 seconds left, sealing Penns one-point victory over the Crimson Tide. Merrimack hit 10 of 11 and Radford hit nine of ten free throws respectively to seal their victories over Northwestern. Rhode Island went 12-12 from the line in the second half during their 14 point victory over Alabama.

There are plenty more examples that could be listed above. However, the bottom line is that mid-major schools did not waste their opportunities for free points. When the average margin of victory is 5.8 points, every point matters, no matter where they come from.

Its no secret that teams should value every possession they get during a game. It can be considered extra important for mid-majors, as not having good possessions can lead to disastrous runs by the opponent that create insurmountable advantages. Thus, mid-major schools need to take as many high-quality shots as possible.

In the case of the seasons first 15 upsets, mid-majors shot an average of 44 percent from the floor compared to 41.3 percent by their opponents. Shooting as close to the rim as possible increases the chances of a made bucket. For example, South Carolina often settled for three-point shots, gong 4-22 from behind the arc in their loss to Boston University. Working the offense from the inside out can lead to success in all three of the areas mentioned so far. Driving the ball into the lane leads to layups and fouls, putting players on the free-throw line. If the defense collapses, theres a good chance a shooter is wide open for an uncontested three-point attempt. In all of those cases, a team is getting the best possible shot on their possession.

The average points-per-possession for the mid-majors in these 15 games is 1.06. Their opponents are only averaging 0.96 points-per-possession. Over 100 possessions, that leads a ten-point advantage for mid-majors. A mid-major upset is made more viable when teams dont waste their offensive touches.

In the one-and-done era, college basketball fans have gotten accustomed to getting one season out of future NBA stars. However, a high percentage of these one-and-done players are taking their talents to power conference schools. At the mid-major level, teams are often built around a strong core of four-year players. That experience can help when it comes to playing in these big games.

Based on KenPoms experience ratings, mid-majors had a 0.36 advantage inexperience in the 15 upsets. While it can be tough to quantify, it is easy for coaches to see when their players experience plays a role in the outcome of a game. Pittsburghs head coach Jeff Capel said his teams maturity just wasnt there yet, and that they needed to grow up during his postgame press conference. Northwestern had five players make their college basketball debuts during their season-opening loss to Merrimack. Many pundits pointed to Kentuckys lack of experience as to why they failed to make a comeback against Evansville during the games final minute.

It truly is a luxury for a coach to have older players on their roster. Three and four-year players have a comfort level with the systems in place with their team. There isnt much that those players havent seen in most game situations. An experienced mid-major can feast off of the inexperience of power conference teams.

The formula above has allowed a mid-major upset to occur 15 times through November 20th. These victories can be program changing when it comes to recruiting and boosting the confidence of the team. Southern Utah got its first victory ever over a Big Ten opponent. Boston University got its first victory ever over an SEC school. In the biggest upset of the year thus far, Evansville picked up their first win ever over the number one ranked team in the AP poll. These victories create lifetime memories for the players and cause a swell of pride amongst alumni everywhere.

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The Mid-Major Upset: An Anatomy - Last Word on Pro Basketball

‘Grey’s Anatomy’: The Similarities Between McWidow and Riggs Will Make You Want to Re-Watch Every Season Since McDreamy Died – Showbiz Cheat Sheet

Its no lie that our hearts have been broken for Meredith (Ellen Pompeo) since McDreamys (Patrick Dempsey) tragic death in season 11 ofGreys Anatomy. However, the show wouldnt be the same drama if Meredith didnt somehow try to get back inthe dating scene.

Thelatest potential love interestfor Meredith has fans wondering if the producers are purposely copying old episodes. Lets take a look at the similarities between McWidow (Shameless Richard Flood) and Riggs (Martin Henderson) to see if the writers just reused old material. Warning: Season 16 Spoilers

The character that is lovingly referred to as McWidow is Dr. Cormac Hayes. He is the new chief of pediatric surgery at Grey-Sloan Hospital. We first meet him during the fall finale of Greys Anatomy.

However, we did not know until the last few minutes of the episode that he was sent to the hospital byCristina Yang(Sandra Oh) as a package for Meredith. Although Cristina left the show in season 10, she and Meredith continually talk and remain twisted sisters.

Hayes and Meredith do not exactly hit it off. The new peds surgeon fights with Meredith about everything the entire day. However, in the last few minutes of the episode, fans are handed an exquisite twist. We find out during an elevator scene that the sexy new doctor with an attractive Irish accent is also a widow.

This new revelation changes everything. We knew that extensive arguing was sexy back and forth banter. Fans sensed the sparks were flying between these two, and the fact that Hayes is a widow, too, is the icing on the cake.

Viewers began an entire discussion about Riggs versus McWidow shortly after the fall finale. Riggs was from New Zealand, so he also had a sexy accent that drove fans wild.

In the middle of season 12 of Greys Anatomy, Riggs came to Grey-Sloan as a new cardio attending surgeon. Meredith and Riggs had the same dysfunctional relationship at their first meeting that Hayes does with Meredith. She disliked both men right away.

We also found out early on that Riggs lost the love of his life, Megan (Abigail Spencer), in what was thought to be a tragic helicopter accident. Of course, both Riggs and McWidow have an encounter with Meredith in an elevator, and we can feel the sexual tension.

Its not about the elevator only, wroteone fan on Reddit. They both lost their women, both started on a bad note with Grey but potentially can be her love interest, and both have sexy accents. Its the same energy.

The similarities between the two love interests are shocking. Fans hope that McWidow lasts longer than Riggs did with Meredith.

During the season 13 finale of Greys Anatomy, Riggs fiance, Megan is found. She was the love of his life, and he is completely torn over her return. Riggs and Megan initially have difficulty resuming their relationship because of Meredith.

However, Meredith tells Riggs to go back to Megan because she would do the same if Derek suddenly reappeared in her life. Riggs makes a grand gesture to Megan by bringing her son home from Iraq, and the three move to Los Angeles to start their life together.

The complications of Merediths emotions, the loss of Derek, and moving on from that still plagues her,Henderson told Deadlineafter his character left the show. And theres as much ambiguity around all those feelings. The two of them found each other, and that provided good drama.

In the end, it was the best thing for Meredith at the time to not end up with Riggs. It was too soon after her husband died for her to be in a serious relationship. However, the entrance of McWidow could be the perfect timing fans are hoping for.

Find out what happens next between McWidow and Meredith when Greys Anatomy returns to ABC on Jan. 23, 2020.

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'Grey's Anatomy': The Similarities Between McWidow and Riggs Will Make You Want to Re-Watch Every Season Since McDreamy Died - Showbiz Cheat Sheet

‘Grey’s Anatomy’: Fans May Hate Catherine Fox, but They Despise Richard Webber Right Now Even More – Showbiz Cheat Sheet

Afterthe fall finaleofGreys Anatomy, fans have a lot to say aboutRichard Webber(James Pickens, Jr.) and Catherine Foxs (Debbie Allen) storyline. None of the comments from fans are positive. Lets take a look and see why fans are so outraged at the two doctors right now.

The root of Richard and Catherines marital problems began at the end of season 15 when Richard was fired from Grey-Sloan hospital for being a part Merediths insurance fraud. Bailey fired Richard; however, Catherine did not do anything to help save his job.

Richard holds a grudge, and Catherine is not helping matters. We are now nine episodes into season 16, and things between the couple are worse than ever before. Catherine assumes that Richard is cheating on her with an old friend, Gemma (Jasmine Guy). Hes not cheating, but hes not doing anything to help Catherine believe him.

The Richard/Catherine marriage problems storyline is so aggravating to me,wrote one fan on Reddit. From Catherines point of view, I understand that she doesnt want to face it, and she keeps running. But from Richards point of view, he should be texting, calling, and chasing after her if nothing is actually going on.

Yes, Catherine did not fight for his job, and hes still upset, but in the grand scheme of things, thats your marriage, and now your wife thinks youre having an affair. If youre not having an affair and its all just innocent friendship, then you would be trying harder to tell your wife that, the Redditor believes.

In the season 16 fall finale, Catherine goes looking for her husband over at Pac-North. A receptionist mistakenly tells her that Richard is busy in his office with his wife. This interaction sets Catherine over the edge, and now she is sure that he is cheating on her. However, he doesnt do anything to deter her from thinking that. She leaves town, and he doesnt try to stop her.

Yes, agrees one fan. Richards like, meh, my wife is leaving town, and I didnt even know she was in town. Whatever. Ok, Gemma what were you saying?'

He couldnt even bother to give her a call, added another Redditor. Thats how much he cares about fixing the current rift. Part of me thinks hes just acting like the victim and being so nonchalant about the whole Gemma thing because he wants to get back at Catherine for not having his back with his job.

Theres a lot of anger in both of them, one fan observed.

Richard needs to stop avoiding his wife, added another fan on Reddit. Catherine should talk to her husband, yes. But Richard knows exactly why Catherine is pissed at him, and he isnt doing anything to try to say hey this isnt happening. He just sits and still hangs out with the woman who Catherine doesnt trust. Come on, Richard. This isnt all on Catherine.

The lack of communication is just, Ugh, added one more Redditor. At least we got one positive thing out of itthe intern sassing Catherine for trying to use her name as power and just not having it with her in general.

Neither party is in the right here. Catherine needs to apologize for not talking to Bailey on his behalf. Richard needs to get over his anger and call his wife. Or, if they are going to go on like this, maybe we will see a divorce. Either way, we wont see anything until Greys Anatomy returns on Jan. 23, 2020.

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'Grey's Anatomy': Fans May Hate Catherine Fox, but They Despise Richard Webber Right Now Even More - Showbiz Cheat Sheet

The anatomy of Central Michigan’s game-winning drive against Ball State – Central Michigan Life

Everything started when senior backup quarterback Tommy Lazzaro scored from 5 yards out.

Lazzaro couldn't contain his excitement and yelled in jubilation. While his celebration drew a 15-yard unsportsmanlike conduct penalty, the score itself cut Ball State's lead to just four points. Senior kicker Ryan Tice's extra point made it a three-point contest.

After trailing by 17 points in the third quarter on Nov. 16 at Scheumann Stadium, the Chippewas clawed their way back into the game. What looked like a blowout earlier in the second half had become a ball game.

It was time to finish the job.

After forcing the Cardinals to punt, the Chippewas took over deep in their territory. Senior graduate transfer quarterback Quinten Dormady was sacked on a third-and-3, and Central Michigan was forced to punt the ball away.

Punting from his end zone, sophomore Brady Buell sent the ball back to the Cardinals.

Ball State took over at midfield, 50 yards away from a touchdown that would've salted away the game.

It didn't start well, as Cardinal quarterback Drew Plitt hit Antwan Davis for an 18-yard gain. Junior running back Caleb Huntley pushed forward for another first down, putting the ball on Central Michigan's 17-yard line.

"That (Ball State) was slowing down," said sophomore linebacker Troy Brown. "They took their foot off the gas pedal."

Brown and the defense locked in, forcing an incompletion on a third-and-9.

Ball State brought out its field goal unit, and Ryan Rimmler's 33-yard field goal made it 44-38 in favor of the Cardinals.

"In the fourth quarter we won four of the five third downs," said defensive coordinator Robb Akey. "We got our act together a little bit."

There was 5:09 remaining. It was last call time for the Chippewa offense.

While Brown and his defensive teammates were making their pivotal stand, the offense began to gather. They knew what was at stake and wanted to be prepared when they needed to take the field.

"They went and scripted, like you would the first drive of the game or first drive of the second half," said first-year coach Jim McElwain. "(The coaches) gave the players what we were gonna do and the players went and executed."

"It's not about the plays, it's about the players executing," said offensive coordinator Charlie Frye. "There were guys on the sideline, and when (Ball State) kicked a field goal, they understood that we had to go down and score."

Dormady, the double graduate transfer who has been through many ups and downs, had just four impactful words for his unit before taking the field: "Let's go be great."

"Big games are gonna come down to the last drive when you've gotta go out and execute," Dormady said.

It started with an incomplete pass and a 3-yard gain for senior running back Jonathan Ward. Facing a third-and-7, the Chippewas' backs appeared to be against the wall.

Dormady had other ideas, hitting Ward out of the backfield for an 18-yard gain to move the chains. Two plays later, he connected with sophomore receiver Kalil Pimpleton for 27 yards.

After an incompletion, Dormady threw a pass to junior receiver JaCorey Sullivan on a corner route to move the chains. Although the pass was originally ruled incomplete, it was determined that Sullivan secured the ball. The completion gave Central Michigan a first down on Ball State's 11-yard line.

The Chippewas were in striking distance.

Lazzaro punched it in from 2 yards out, and Tice's extra point gave the Chippewas a one-point advantage, 45-44.

Just 61 seconds remained in the contest.

"The sense of urgency and focusing on the details, that's what I saw," Frye said. "Plays will always be plays, it's about the players going out and executing their jobs and doing what they're doing for each other so that we can go out and win the game."

"For that last drive, (it was about) just execution," Dormady said. "Going out and being great."

It would be up to the defense to get the final stop and secure the comeback victory.

The defense allowed 499 yards of offense and two running backs over 100 yards on the ground. The game was not over, and the Chippewa defense was entering their metaphorical "Ring of Fire" stage of the contest.

Brown, Akey and others were licking their chops.

"Our defense, as a whole, we know when we're working together we're pretty much unstoppable," Brown said. "We knew we had to come away with the takeaway."

"The good Lord created the defense to give the ball back to the offense without giving up points," Akey said.

In the spirit of coach Herman Boone, the Chippewas did not allow another yard. Three consecutive incompletions led to a pivotal fourth-and-10 for Ball State.

"I was just dropping back," Brown said. "Our defensive line did a good job of getting pressure and (Plitt) was forced to throw on a scramble. He threw it to me and I knew I had to make a play."

Brown's third interception of the season sealed the victory. Three kneel downs later, the Chippewas made the victory official.

McElwain hugged numerous players. Pimpleton and Ward did multiple backflips. The field was full of ecstatic Chippewas.

It was pandemonium.

McElwain: "Signature wins happen when adversity hits. We had a lot of it today."

Akey: "The bottom line is we won the game. You better appreciate that because wins are hard to get."

Frye: "They (the players) showed the resiliency to not just get back into the game, but to finish it. It's not easy to do and they should feel very proud."

Dormady: "I've been through a lot personally. To get this win, with this group of guys, I can't tell you what it means to me."

For Dormady, it may very well be a career-defining victory.

For McElwain, it may boost him to the Mid-American Conference Coach of the Year award.

In a game with MAC West Division title implications, the Chippewas got it done.

A team that finished 1-11 last season battled together to secure a victory from the jaws of defeat.

"They stuck together," Frye said. "It's awesome to see that."

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The anatomy of Central Michigan's game-winning drive against Ball State - Central Michigan Life

52 UC San Diego Researchers Are Most Highly Cited in Their Fields – UC San Diego Health

Fifty-two faculty members and researchers at the University of California San Diego are among the worlds most influential in their fields. The Web of Science Group, an information and technology provider for the global scientific research community, compiled its2019 Highly Cited Researcherslist of more than 6,000 scientists from around the world whose studies were among the top 1% of most-cited publications in their field over the past 11 years.

The number of highly cited researchers from UC San Diego increased by 13% over last years number of forty-six. The listing covers 21 fields of study as well as a cross-field category for researchers who are widely cited across multiple fields. UC San Diego had researchers listed in 14 fields, with the most cited in cross-field (23), followed by molecular biology and genetics (5), clinical medicine (4) and social sciences (4).

UC San Diego has some of the most dedicated, brilliant and hard-working faculty and researchers in the world. Their inclusion on the list of highly cited researchers is a measure of their impact in their respective fields of study as they continue to advance the frontiers of knowledge, said Chancellor Pradeep K. Khosla.

Of particular note is Director for the Center of Microbiome Innovation Rob Knights inclusion in three separate areas of study (biology and biochemistry, environment and ecology, microbiology). Out of 6,216 highly cited researchers, only 11 were cited in three fields, making Knight part of a super elite 0.3% of those listed.

There were also 23 Nobel laureates on the list, one of whom, Roger Tsien, was a distinguished professor of both Pharmacology in the School of Medicine and of Chemistry and Biochemistry at UC San Diego until his death in 2016. He shared the Nobel Prize in Chemistry with two others in 2008 for discovering and developing green fluorescent protein.

David Pendlebury, Senior Citation Analyst at the Web of Science Groups Institute for Scientific Information said that the highly cited researchers create gains for society, innovation and knowledge that make the world healthier, richer, more sustainable and more secure.

It is especially encouraging to see not only the number of highly cited researchers at the university, but the broad range of fields in which they are cited. It really speaks to the fact that UC San Diego conducts groundbreaking research across a wide range of disciplines, said Vice Chancellor for Research Sandra A. Brown. I congratulate everyone on their excellent research and contributions.

The 52 UC San Diego faculty members named by Web of Science and the fields of study in which they were cited are:

Gregory Aarons,social sciences

Ludmil Alexandrov, molecular biology and genetics

David Brenner,cross-field

Kristin Cadenhead,psychiatry/psychology

Kelli Cain, social sciences

Shu Chien, cross-field

Don Cleveland,neuroscience and behavior

Seth Cohen,chemistry

Pieter Dorrestein,cross-field

Mark Ellisman, cross-field

Mark Estelle,plant and animal science

Michael Folger, cross-field

Anthony Gamst, cross-field

Christopher Glass,molecular biology and genetics

Uri Gneezy,economics and business

Antonio Gonzalez, microbiology

Kun-Liang Guan,molecular biology and genetics

Trey Ideker,cross-field

Michael Karin,molecular biology and genetics

Arthur Kavanaugh,clinical medicine

Dusan Keres, space science

Rob Knight,(listed in 3 fields) biology and biochemistry, environment and ecology, microbiology

Razelle Kurzrock, clinical medicine

Lisa Levin, cross-field

Irene Litvan, neuroscience and behavior

Rohit Loomba, clinical medicine

Prashant Mali, biology and biochemistry

Eliezer Masliah, cross-field

Victor Nizet, cross-field

Jerrold Olefsky,cross-field

Bernhard Palsson,biology and biochemistry

Veerabhadran Ramanathan,cross-field

Bing Ren,molecular biology and genetics

Jeremy Rich, cross-field

Douglas Richman,cross-field

Michael Sailor,cross-field

James Sallis,social sciences

William Sandborn,clinical medicine

Bernd Schnabl, cross-field

Julian Schroeder,plant and animal science

Terrence Sejnowski, cross-field

Claude Sirlin, cross-field

Murray Stein,psychiatry/psychology

Steffanie Strathdee, cross-field

Roger Tsien, cross-field

Ming Tsuang,psychiatry/psychology

Joseph Wang,chemistry

Shang-Ping Xie,geosciences

Gene Yeo, cross-field

Kun Zhang, cross-field

Liangfang Zhang,cross-field

Yunde Zhao, plant and animal science

Shu-Hong Zhu, social sciences

You can read about Web of Sciences methodology on their website.

UC San Diegos Studio Ten 300 offers radio and television connections for media interviews with our faculty. For more information, email .(JavaScript must be enabled to view this email address).

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52 UC San Diego Researchers Are Most Highly Cited in Their Fields - UC San Diego Health

Three UWMadison students named 2020 Rhodes finalists – University of Wisconsin-Madison

Three University of WisconsinMadison students reached the final stage of competition this year for Rhodes Scholarships, the oldest and most celebrated college awards for international study.

The 32 Americans chosen as Rhodes Scholars were announced Saturday. An additional 204 students were finalists for the coveted awards, including UWMadison students Kevin Crosby, Claire Evensen and Lauren Jorgensen.

To be a finalist is truly remarkable, and we congratulate Claire, Lauren and Kevin on this impressive accomplishment and on all theyve achieved, says UWMadison Provost John Karl Scholz. These three students have been leaders on our campus, in the community, and beyond. I want to thank them for reflecting so well on this institution and on the many opportunities we offer to learn in and outside the classroom what we call the Wisconsin Experience.

Hundreds of elite applicants from dozens of colleges and universities vie for the Rhodes Scholarships each year. Candidates are judged on a proven record of intellectual and academic achievement, integrity of character, interest in and respect for others, leadership ability, and the energy to fully utilize their talents.

UWMadisons finalists excel in science, research and service to the campus and community.

Kevin Crosby

Crosby, a senior from Brandywine, Maryland, is majoring in nutritional sciences, with a certificate in environmental studies. He has interned three summers at the National Institute of Allergy and Infectious Diseases (part of the National Institutes of Health) and two years at the William S. Middleton Memorial Veterans Hospital in Madison. He received a competitive National Science Foundation scholarship to participate in the Community Environmental Scholars Program through the Nelson Institute for Environmental Studies at UWMadison.

Crosby serves as a peer mentor for both the Physics Learning Center on campus and the Department of Biochemistry, and hes an undergraduate teaching assistant in the Department of Nutritional Sciences.

Outside the classroom, Crosby has volunteered as a cultural coalition chair for a consortium of three residence halls, working with a team to create a more culturally inclusive campus. Through the Badgers Volunteers Program, he has assisted with the operation of The River food pantry in Madison and an afterschool program at a local elementary school.

Crosby attends UWMadison on a full-tuition scholarship through the Posse Foundation, which identifies students with extraordinary leadership potential and partners with top universities to diversify their applicant pools. He will graduate in the spring.

Claire Evensen Photo by Sheyenne Tung

Evensen, a senior from Verona, Wisconsin, is majoring in biochemistry and mathematics, with comprehensive honors (honors in biochemistry and in the liberal arts). She will graduate in the spring.

She is both a Goldwater Scholar and an Astronaut Scholar national awards that support the next generation of scientists, explorers and innovators. For three years, Evensen has researched the biophysics of transcription initiation with John D. Ferry Professor of Biochemistry Thomas Record. She has earned several prestigious campus research grants to support her work, including a Hilldale Undergraduate Research Fellowship, the universitys top research grant. She has presented her research at national conferences and earned second authorship on a paper published in the journal Biochemistry.

As president of the UWMadison student chapter of the American Society for Biochemistry and Molecular Biology, Evensen has organized a regional conference so that her fellow members can benefit from the research presentation and networking opportunities she has had. She secured regional meeting status from the national organization, raised funds for a $10,000 budget, and recruited a student planning team. This coming March, roughly 200 undergraduates from throughout the Midwest are expected to attend the Molecules in the Midwest conference at UWMadison.

Lauren Jorgensen

Jorgensen, of Stillwater, Minnesota, graduated from UWMadison in May 2019 with a bachelors degree in agronomy and community and environmental sociology, with certificates in environmental studies, food systems, and global health. She currently is pursuing a masters degree in public affairs through an accelerated program at the Robert M. La Follette School of Public Affairs at UWMadison. She expects to complete the masters degree in the spring.

Early in her undergraduate career, Jorgensen developed an interest in food access and food policy. Since 2017, she has interned with the UWMadison School of Medicine and Public Healths Population Health Institute, where she has helped develop a school wellness policy initiative and evaluate a statewide public health nutrition program. As a food policy intern with the city of Madison, Jorgensen produced a map of food insecurity within the city limits. For her senior thesis, she researched rural and urban food insecurity throughout Wisconsin. She received a Hilldale Undergraduate Research Fellowship to support her work. On campus, she helped establish the Campus Food Shed, which recovers edible produce that would otherwise be thrown away.

Rhodes Scholarships typically provide all expenses for two or three years of study at Oxford University in England. This years winners will enter Oxford next fall and are referred to as the 2020 class of Rhodes Scholars.

UWMadisonslast Rhodes Scholarswere Colin Higgins (Rhodes Class of 2016), Drew Birrenkott (Class of 2014), and Alexis Brown (Class of 2012).

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Meet the Researcher: Riqiang Yan, Neuroscience – UConn Today

When he first entered college, Riqiang Yan wanted to be a doctor. But he soon changed paths when he realized how exciting the research tract was.

When I had just graduated high school, I was kind of nave. I didnt know much about the field until I came to college and became more fascinated by the research, Yan says. I wanted to make knowledge in the science part.

Yan began doing research during his undergraduate thesis project, which was trying to develop a new drug formulation for ulcer treatment at Shanghai Medical University. He was so interested in the project that he continued working on it even after his graduated, which was very unusual at that time for a student who otherwise could have enjoyed time off during the summer break. Yan credits Prof. Yuanming Ma () with providing him that opportunity, and guided him toward the research career path he eventually followed. Following this experience, Yan received his masters degree in biochemistry at Shanghai Medical University and went on to earn his Ph.D. in biochemistry at the University of Kentucky.

Yan is now one of the worlds leading Alzheimers disease researchers. He is a professor and chairman of UConn Healths Department of Neuroscience, leading discovery efforts at UConns School of Medicine. Yan came to UConn from the Cleveland Clinic in 2018. He established the first research program focused on studying Alzheimers and other forms of neurodegenerative disease in hopes of potentially discovering effective treatments.

Yans arrival at UConn also ushered in a host of research collaboration opportunities across the School of Medicine and its departments of neurology, neurosurgery, psychiatry, neurobiology, the Center on Aging, and brain investigators at the University, as well as with the Jackson Laboratory for Genomic Medicine on UConn Healths campus.

Cutting-Edge Alzheimers Research

Now a preeminent scholar in the field, Yan didnt start out doing Alzheimers research. At the beginning of his independent research career, Yan was studying inflammation in lung diseases for global pharmaceutical company Pharmacia & Upjohn. When the companys priorities changed, Yan shifted over to Alzheimers research. The neurodegenerative disease that affects an estimated 5.5 million Americans has no known cure.

I ended up in Alzheimers research by accident, Yan says. It was a very exciting time because we had so many unknown questions about Alzheimers disease to explore.

That accident turned out to be extremely productive. One year after making the switch, Yan made a breakthrough discovery.

In 1999, Yan and several other groups of researchers simultaneously discovered that an enzyme known as BACE1 plays a crucial role in the processes that lead to the onset of Alzheimers disease. BACE1 cleaves amyloid precursor proteins which give rise to beta amyloid. This peptide is the main component of plaques on brain cells, one of the culprits for causing Alzheimers disease.

From there, researchers from multiple pharmaceutical and biotech companies began developing trials of BACE1 inhibitors in hopes of stopping the effects of BACE1s activity. However, all these trials failed. While these failures were frustrating, they taught scientists an important lesson about this key enzyme; not only does BACE1 activity lead to Alzheimers disease, it is also responsible for ensuring parts of normal neural activity. By blocking it completely, the treatments did more harm than good.

Things Are Not So Simple

We still dont have a drug, Yan says, 20 years after the original discovery. These early trials with BACE1 failed because if you simply inhibit it, it interferes with necessary brain functioning. Its challenging.

Yan reflects that this is one of the most challenging aspects of his research. The human body is not simple, and neither are the diseases that afflict it. Before we can develop an effective treatment for Alzheimers disease, we need to understand how it works at a basic molecular level.

Many times, you will find out things are not so simple, Yan says. We need to understand the biology before we can have an effective drug.

Most recently, Yan published a paper in the Journal of Experimental Medicine about the role of CX3CL1, a transmembrane protein, on Alzheimers disease. Yan found that CX3CL1 is cleaved by BACE1. He also found that an overexpression of the C-terminal fragment of CX3CL1 can reduce amyloid deposition and neuron loss in mice with Alzheimers disease. This is the first time its been shown that the C-terminal CX3CL1 can aid adult neurogenesis which directly combats the neurodegeneration of Alzheimers disease.

This development of knowledge underscores the role of academic researchers in eventual drug discovery, Yan says. Developing knowledge about diseases and the workings of the human body is the foundation for future drugs.

Were in academia. Our main focus is to understand the molecule first before we try to develop a compound, Yan says.

If researchers or pharmaceutical companies go into drug trials without this critical understanding, they could encounter many harmful side effects. With a better understanding of the science behind the disease, such side effects could be better anticipated and even avoided.

Yan says researchers can help pharmaceutical companies develop more effective drugs by working in tandem with industry partners.

We may not be able to compete with the pharmaceutical companies directly in some cases, but we can do something to help the companies develop better drugs, Yan says. And thats whats more important to us.

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FDA-approved drug to prevent organ rejection may slow skin aging – News-Medical.net

The search for youthfulness typically turns to lotions, supplements, serums and diets, but there may soon be a new option joining the fray. Rapamycin, a FDA-approved drug normally used to prevent organ rejection after transplant surgery, may also slow aging in human skin, according to a study from Drexel University College of Medicine researchers published in Geroscience.

Basic science studies have previously used the drug to slow aging in mice, flies, and worms, but the current study is the first to show an effect on aging in human tissue, specifically skin - in which signs of aging were reduced. Changes include decreases in wrinkles, reduced sagging and more even skin tone -- when delivered topically to humans.

As researchers continue to seek out the elusive 'fountain of youth' and ways to live longer, we're seeing growing potential for use of this drug. So, we said, let's try skin. It's a complex organism with immune, nerve cells, stem cells - you can learn a lot about the biology of a drug and the aging process by looking at skin."

Christian Sell, PhD, senior author and associate professor of Biochemistry and Molecular Biology at the College of Medicine

In the current Drexel-led study, 13 participants over age 40 applied rapamycin cream every 1-2 days to one hand and a placebo to the other hand for eight months. The researchers checked on subjects after two, four, six and eight months, including conducting a blood test and a biopsy at the six- or eight-month mark.

After eight months, the majority of the rapamycin hands showed increases in collagen protein, and statistically significant lower levels of p16 protein, a key marker of skin cell aging. Skin that has lower levels of p16 has fewer senescent cells, which are associated with skin wrinkles. Beyond cosmetic effects, higher levels of p16 can lead to dermal atrophy, a common condition in seniors, which is associated with fragile skin that tears easily, slow healing after cuts and increased risk of infection or complications after an injury.

So how does rapamycin work? Rapamycin blocks the appropriately named "target of rapamycin" (TOR), a protein that acts as a mediator in metabolism, growth and aging of human cells. The capability for rapamycin to improve human health beyond outward appearance is further illuminated when looking deeper at p16 protein, which is a stress response that human cells undergo when damaged, but is also a way of preventing cancer. When cells have a mutation that would have otherwise created a tumor, this response helps prevent the tumor by slowing the cell cycle process. Instead of creating a tumor, it contributes to the aging process.

"When cells age, they become detrimental and create inflammation," said Sell. "That's part of aging. These cells that have undergone stress are now pumping out inflammatory markers."

In addition to its current use to prevent organ rejection, rapamycin is currently prescribed (in higher doses than used in the current study) for the rare lung disease lymphangioleiomyomatosis, and as an anti-cancer drug. The current Drexel study shows a second life for the drug in low doses, including new applications for studying rapamycin to increase human lifespan or improve human performance.

Rapamycin -- first discovered in the 1970s in bacteria found in the soil of Easter Island - also reduces stress in the cell by attacking cancer-causing free radicals in the mitochondria.

In previous studies, the team used rapamycin in cell cultures, which reportedly improved cell function and slowed aging.

In 1996, a study in Cell of yeast cultures which used rapamycin to block TOR proteins in yeast, made the yeast cells smaller, but increased their lifespan.

"If you ramp the pathway down you get a smaller phenotype," said Sell. "When you slow growth, you seem to extend lifespan and help the body repair itself - at least in mice. This is similar to what is seen in calorie restriction."

The researchers note that, as this is early research, many more questions remain about how to harness this drug. Future studies will look at how to apply the drug in clinical settings, and find applications in other diseases. During the current study, the researchers confirmed that none of the rapamycin was absorbed in the bloodstream of participants.

There are two pending patents on this technology, both of which have been licensed to Boinca Therapeutics LLC., of which Sell, Ibiyonu Lawrence, MD, an associate professor of Internal Medicine in the College of Medicine, are shareholders.

Source:

Journal reference:

Chung, C.L., et al. (2019) Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. Geroscience. doi.org/10.1007/s11357-019-00113-y.

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The promise of terpenoids for human health – Varsity

Mangoes contain high quantities of Vitamin A, which is a type of terpenoid. BRIGITTE TOHM/UNSPLASH | IMAGE HAS BEEN CROPPED

The word terpenoid is not only limited to rhyming with words such as meteoroid, avoid, and steroid it also symbolizes organic compounds produced by plants that offer significant medicinal and pharmacological benefits to humans.

In a review paper, U of T scientists explored the vast role that these chemicals play in our everyday lives.

Co-authors Dr. Michael Phillips, an assistant professor at UTMs Department of Biology; and Matthew Bergman, a graduate student at the same department, discussed thefindings of this review with The Varsity.

Relevance of terpenoids

The presence of terpenoids can be found all around us. Vitamin A is an example, along with the chemical that is key to the unique smell of pine.

The review explained that terpenoids can attract pollinators, repel herbivores, or attract herbivore predators. This has broad impacts on fields such as agriculture.

Terpenoids also feature heavily in cannabis. Specialized terpenoids include well-known compounds such as cannabidiol also known as CBD and tetrahydrocannabinol THC.The compounds have been used for their psychoactive, anxiolytic and anesthetic effects for thousands of years, according to the co-authors.

The ability to make these terpenoids evolved as a result of selective pressures imposed by animals on plants. A great sense of irony lies in the fact that these chemical compounds, which often serve as plant defence compounds against herbivorous insects, possess fortuitous uses in medicine.

The reason that these compounds are biologically active in humans is in part due to the fact that our proteins are made up of exactly the same amino acids as the plant proteins, noted Phillips.

Applications of the review

Phillips hopes to use his review partly as a teaching tool but also [to] summarize the literature that is important for [his] field.

Bergman also spoke aboutthe implications that his research would have on non-specialists in biology. Theres a lot of interest right now in medicinal plants and theres a lot of confusion surrounding what are the active constituents, he said.

By conducting the review, Bergman hopes to eliminate some of this confusion.This is important because theres a connection between [our research] and what [consumers] find in the grocery store, added Phillips.

The future of terpenoid research

In many cases, terpenoid-based medications could hold promise in health care, by virtue of the fact of how much common ancestry we share with herbivores that terpenoids evolved to affect, noted Phillips.

While many terpenoids represent potentially beneficial compounds for humans, the testing process is painstaking and resource intensive, according to the review. This process is further obstructed by the fact that many [terpenoids] are produced in small amounts, and only in response to elicitation.

Additionally, while the amount of plant terpenoids that can be screened for therapeutic applications is still unknown, it likely surpasses over 100,000 variants, according to the co-authors. With a review of terpenoids completed, researchers now have a tool to develop plans for further research in the field of plant biochemistry.

Tags: Biochemistry, botany, Chemistry, medicine, organic chemistry, Science

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The promise of terpenoids for human health - Varsity

Rapid genetic test traces spread of fungus that kills frogs, reveals new strain in Southeast Asia – Mongabay.com

Protecting frogs against the invisible killer called chytrid was never going to be easy. The fungus has already wiped out more species than any other known disease. But a recent study of the worldwide spread of the fungus shows that the task will be even harder than scientists expected.

The study is the first to use skin swabs from amphibians to identify the major strains of the fungus. Researchers found regions where strains could combine into deadly hybrids. They also found a previously unknown variant in Southeast Asia, which has not yet spread globally.

The findings, published Sept. 23 in the Proceedings of the National Academy of Sciences, show that ecologists will need to track these distinct fungal variants to protect frogs more fully. Mutations in the fungus make it a moving target in much the same way as the ever-shifting influenza virus.

There [are] amazing, last vestiges of really diverse amphibian communities, said environmental scientist Erica Bree Rosenblum of the University of California, Berkeley, senior author of the study. If we can protect them from having a really deadly chytrid strain, that would be great.

Chytrid infects the thin, moist skin frogs use to absorb water and balance their levels of sodium, chloride and potassium. An infected frog, unable to maintain a steady heartbeat, will die of a heart attack. The fungus then releases spores into the water to infect the next frog. This deadly cycle is responsible for the decline of more than 500 amphibian species. About 90 species have gone extinct in the past 50 years, ecologists believe, including Australias Mount Glorious torrent frog (Taudactylus diurnus), last seen in 1979.

Some chytrid variants are deadlier than others. However, most genetic tests only reveal whether any fungus is present. The current way to identify the lineage of a fungus is to sequence its entire genome, a time-consuming step.

Rosenblums team, including first author Allison Byrne at UC Berkeley, devised a less laborious approach: a genetic test that works on small amounts of low-quality DNA. They tested 222 frog skin swabs from six continents and 24 countries. The massive international collaboration mobilized 30 co-authors.

The tests uncovered a new variant in China, Indonesia and the Philippines, which fits scientists understanding that the disease probably started in Asia. Researchers also found variants in unexpected places. For example, a lineage previously reported in Europe and Africa also turned up on frogs in Latin America.

This paper has been a long time coming, said evolutionary biologist Timothy James of the University of Michigan, who was not involved in the study. It validates some hypotheses and shows the way forward.

Many regions hosted multiple strains of the fungus. In some cases, frogs with different variants lived within meters of each other. That proximity worries Rosenblum. Strains could form deadlier hybrids in places like Brazil, where American bullfrogs (Lithobates catesbeianus) are farmed as pets and food. The new skin swab genetic test could allow officials to screen shipments of frogs before they go overseas, Rosenblum has proposed.

The teams approach could also help scientists learn how chytrid became so deadly to begin with. Museum samples have shown that the fungus existed on frogs collected in the early 1900s. However, mass die-offs didnt begin until the 1970s. Museum archives, examined with the new test, could identify what changed: from tweaks in the genetics of the fungus to the rise of international amphibian trade and global travel.

The effects of globalization for disease transmission around the world are so palpable, Rosenblum said. If were worried about moving diseases around the world for our own species, then we should also be worried about moving diseases around the world for other species.

Citation

Byrne, A. Q., et al. (2019). Cryptic diversity of a widespread global pathogen reveals expanded threats to amphibian conservation.Proceedings of the National Academy of Sciences,116(41), 20382-20387. https://doi.org/10.1073/pnas.1908289116

Jonathan Wosen (@JonathanWosen) is a graduate student in the Science Communication Program at the University of California, Santa Cruz. Other Mongabay stories produced by UCSC students can be found at https://news.mongabay.com/list/ucsc/

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Rapid genetic test traces spread of fungus that kills frogs, reveals new strain in Southeast Asia - Mongabay.com