Susana Alcantara, senior research scientist and neuroscience program leader at Sartorius, discusses her positive experience of presenting a webinar withSelectScience andher pride that the webinar later won a covetedBest in Digital Marketing Awardat Neuroscience 2019.
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Live-cell analysis in neuroscience research: An award winning webinar - SelectScience
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Latest Approach on Neuroscience Antibodies Assays Market 2019 | Growth, Demand, Scope & Forecast by 2025 | Top Key Players: Thermo Fisher...
Neuroscience research at the University of Sheffield has been recognized by Her Majesty The Queen for delivering real benefits in improving patient outcomes for people living with some of the most devastating neurodegenerative diseases.
The Sheffield Institute for Translational Neuroscience (SITraN) based at the University of Sheffield was awarded a Queen's Anniversary Prize today (21 November 2019) at St James's Palace.
The prize awarded to SITraN is unique in the honors system and only bestowed upon a UK college or university which demonstrates new and innovative approaches to its research and development that have delivered benefits to the public at local, national and global levels.
SITraN's vision is to harness the rapidly emerging, exciting developments in neuroscience to translate into new treatments and improved quality of life for patients with neurodegenerative disorders such as Parkinson's Disease, Motor Neurone Disease (MND), Dementia and Alzheimer's Disease and Multiple Sclerosis (MS).
Achievements highlighted by the award include:
Professor Dame Pamela Shaw, Director of SITraN, said: "Receiving this award is a great honor. It gives recognition to our research teams who have made enormous scientific progress in treating some of the most devastating neurological diseases, making a real difference to patients' lives.
"We hope that this award will inspire confidence for patients and their families, research partners and donors as we continue to make discoveries that deepen the understanding of neurological diseases and open up the potential for new treatments and therapies."
SITraN - which will celebrate its 10th anniversary in 2020 - is considered a world-leader in neuroscience research. Its work forms part of the University of Sheffield's Neuroscience Institute, which aims to bring academics together from across varied specialties to translate scientific discoveries from the lab into pioneering treatments that will benefit people living with neurodegenerative diseases.
Professor Koen Lamberts, President and Vice-Chancellor of the University of Sheffield, said: "It's wonderful to see the Queen's Anniversary Award recognizing the University of Sheffield as a center for excellence in neuroscience research and teaching which has the power to transform people's lives.
"As well as making life-changing discoveries today, SITraN is nurturing the next generation of talented neuroscience students, whose research will lead to pioneering treatments for those living with neurological diseases in the future."
Chair of the Royal Anniversary Trust, Sir Damon Buffini, said: "The prizes are granted every two years by the Queen and are the most prestigious national honor awarded to UK universities and colleges for their work.
"Entries in the scheme are invited in any subject area and are subjected to rigorous independent assessment in a process managed by the Royal Anniversary Trust. Recommendations for the Queen's approval are made on the Prime Minister's advice.
"The criteria are demanding and look for outstanding excellence in the chosen field, for innovation and for evidence of real public benefit. Competition is strong and the award is a mark of high quality in education and training which is widely recognized internationally as well as in the UK."
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University of Sheffield receives Queen's Anniversary Prize for innovation in neuroscience - News-Medical.net
Oksana Zinchenko, Research Fellow at the Institute of Cognitive Neuroscience, HSE University, has conducted a meta-analysis of 17 articles to find out which areas of the brain are involved decision-making for rendering social punishment. It would appear that in case of both victims of violations as well as witnesses, punishment decisions activate the brain regions responsible for focusing one's attention, processing information, and responding effectively to social interaction. The findings of the study were published in Scientific Reports.
Social punishment is necessary in order to maintain order and cooperation in society. In their everyday lives, people who have committed wrongdoings may face reprimand or rejection. A decision to invoke punishment may be implemented by a person who was affected because of such a violation of norms ('second-party punishment'), or by a neutral person, who nevertheless knows about the norm violation ('third-party punishment'). It used to be a known fact that certain brain areas activate in victims of violations as well as in witnesses in response to different forms of social punishment. However, it was not entirely clear to date which areas were activated in particular.
A typical game for the study of social punishment is the Ultimatum where one test subject makes a decision about how much of the amount given to him or her will be given to another subject. The participant is free to divide it up as he or she likes, even keeping the entire amount. If the second participant finds the decision unfair, they can punish the offender (for example, reject the proposed division), i.e. execute 'second party punishment'. Alternatively, the punishment can be invoked by the third test subject, the witness of the transaction, which will constitute third-party punishment.
Oksana Zinchenko employed activation likelihood estimation (ALE) to analyze data on the brain activity of 383 participants of 17 studies devoted to the subject of social punishment. The participants were either playing the Ultimatum game or were engaged in other types of strategic games simulating norm-violating events that would result in a social punishment. While the participants were performing these tasks, the researchers applied functional Magnetic Resonance Imaging (fMRI) to record their brain activity.
The analysis revealed that such areas of the brain as the bilateral claustrum (upon activation, spreading to the insular cortex), the left superior frontal and right interior frontal gyri were always activated for social punishment tasks. These areas related to either the salience network or central-executive network of the brain. These neuron systems are responsible for focusing attention, detecting errors, and processing contextual information - all essential components for punishment decision-making. The right interior frontal gyrus is regarded as a key region in the brain's 'emotional empathy network', required for adequate responses to various social interactions. As for the left superior frontal gyrus, its main function is believed to store information in the working memory during decision-making processes.
However, the meta-analysis revealed no concordant activation in other brain regions, including those corresponding with the mentalizing network, which operate in a different way with respect to second-party and third-party punishments. This network is responsible for evaluating a wrongdoer's intentions. Some regions of this network may be triggered differently, depending on the type of punishment under consideration.
The researchers have yet to perform a more in-depth analysis of the differences in the brain's responses to various types of social punishment. Meanwhile, we can better understand what mechanisms underlie social control and people's ability to cooperate by studying the similarities in information processing related to social punishment.
Reference: Zinchenko, O. (2019). Brain responses to social punishment: a meta-analysis. Scientific Reports, 9(1), 18. https://doi.org/10.1038/s41598-019-49239-1
This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.
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Which Areas of the Brain Decide Punishment? - Technology Networks
BOCA RATON, Fla., Nov. 23, 2019 /PRNewswire/ -- Florida Atlantic University faculty, staff and students came together with local officials and community partners today to celebrate the 20th anniversary of FAU's John D. MacArthur Campus at Jupiter with a ceremonial groundbreaking for the new FAU Neuroscience Building and a new residence hall.
"I can't think of a better way to commemorate the 20th anniversary of our Jupiter campus than with a celebration marking the construction of two new state-of-the-art buildings," said FAU President John Kelly. "Our Jupiter campus is the only place on earth where Scripps and Max Planck sit next to each other, and FAU is working to ensure this incredible synergy is leveraged to create a unique learning laboratory where exemplary students can shine."
The university will construct the 58,000-square-foot FAU Neuroscience Building to enhance collaborative research with Scripps Research and Max Planck Florida Institute for Neuroscience (MPFI). The building will increase shared research and office space for new STEM faculty and provide the additional teaching and instructional space needed to support projected enrollment growth, especially in specific areas such as neuroscience, biotechnology, bioengineering, bioinformatics/data science and chemistry. The structure will also support increasing FAU intellectual property licensing activity and "spinout" companies. The $35 million transformative research space represents a significant investment by the state of Florida, FAU and its research partners. Construction is expected to start in the summer of 2020.
The $17.1 million, 165-bed residence hall will provide a total of 435 beds for the Jupiter campus that is currently at max capacity. Construction will begin in spring 2020 with completion set for summer 2021. Residential students living in the new hall will enjoy a fitness area, study rooms, laundry on each floor, computer lab and a rooftop patio.
These two new structures build on FAU's aggressive moves to ramp up its research footprint and academic offerings at the Jupiter campus. In November 2018, FAU expanded on existing graduate and undergraduate opportunities with the announcement of the FAU-Max Planck Academy, the only academic program in the world that will allow the brightest STEM high school students to work side-by-side with preeminent scientists at one of the world's leading neuroscience research institutions. FAU, MPFI and the Germany-based Max Planck Society will welcome the academy's first class in the fall 2020 semester.
"I am incredibly proud of the strides that FAU and the world-class research institutes located on its campus have made in building a robust life science ecosystem in Palm Beach County," said State Rep. MaryLynn Magar. "I am honored to carry that message to Tallahassee and encourage my fellow legislators to continue the state's investment in the unprecedented educational programs and groundbreaking research partnerships that are taking place here in Jupiter."
Other 20th anniversary celebratory events include a ribbon cutting on May 11, 2020 when FAU and MPFI officials open the FAU-Max Planck Academy building.
Named after businessman and philanthropist John D. MacArthur, FAU's Jupiter campus opened on 135 acres of land donated by the John D. and Catherine T. MacArthur Foundation in the fall of 1999. The campus established the nationally ranked Harriet L. Wilkes Honors College, the first public honors institution to be built from the ground up in the United States. FAU's Jupiter campus was built into the master plan of the Abacoa community to help engage local residents and to serve the people of Palm Beach and Martin counties. In 2005, FAU welcomed Scripps Research faculty and staff to its Jupiter campus and a groundbreaking for the MPFI building was held in 2010.
In addition to being home to Scripps Research and MPFI, FAU Jupiter is home to the faculty labs of the Charles E. Schmidt College of Science. Recognized as a center of scientific activity, the campus also serves as the headquarters for two of FAU's primary research organizations, the Brain Institute and the Institute for Human Health and Disease Intervention (I-HEALTH). The College of Education also hosts the Academy for Community Inclusion and the community-centered Center for Autism and Related Disabilities (CARD) program on the Jupiter campus. The Osher Lifelong Learning Institute, housed in the Elinor Bernon Rosenthal Lifelong Learning Complex on the Jupiter campus, is the largest membership organization of its kind in the country delivering personal enrichment courses covering a broad range of stimulating topics that are taught by leading experts.
- FAU -
About Florida Atlantic University: Florida Atlantic University, established in 1961, officially opened its doors in 1964 as the fifth public university in Florida. Today, the University, with an annual economic impact of $6.3 billion, serves more than 30,000 undergraduate and graduate students at sites throughout its six-county service region in southeast Florida. FAU's world-class teaching and research faculty serves students through 10 colleges: the Dorothy F. Schmidt College of Arts and Letters, the College of Business, the College for Design and Social Inquiry, the College of Education, the College of Engineering and Computer Science, the Graduate College, the Harriet L. Wilkes Honors College, the Charles E. Schmidt College of Medicine, the Christine E. Lynn College of Nursing and the Charles E. Schmidt College of Science. FAU is ranked as a High Research Activity institution by the Carnegie Foundation for the Advancement of Teaching. The University is placing special focus on the rapid development of critical areas that form the basis of its strategic plan: Healthy aging, biotech, coastal and marine issues, neuroscience, regenerative medicine, informatics, lifespan and the environment. These areas provide opportunities for faculty and students to build upon FAU's existing strengths in research and scholarship. For more information, visit http://www.fau.edu.
This news release was issued on behalf of Newswise. For more information, visit http://www.newswise.com.
Media Contacts: Lynda RysavyLFigueredo@fau.eduPhone: 561-475-0960
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SOURCE Florida Atlantic University
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Groundbreaking for Neuroscience Building and Residence Hall Mark 20th Anniversary Of FAU's John D. MacArthur Campus - BioSpace
Finding it difficult to convince prospective clients that something really bad might happen to them?
What you are up against is the normal brain function for four-tenths of the general population and the fact that people still smoke is one clue, a speaker suggested Monday at the Top Broker Summit.
Keynote speaker Tali Sharot showed the summit a slide with a photo of a cigarette package warning the buyer that smoking kills.
Threats and warnings like this only have limited impact because people say, Yes, smoking kills but mostly it kills the other guy, said Sharot, a professor of cognitive neuroscience at University College in London, England.
Optimism bias is the tendency to imagine the future as being more positive for people to over-estimate the likelihood of positive events and underestimate the likelihood of negative events.
When we renovate our house, we think about how lovely this house will be and we dont necessarily focus on that burst pipe or that tree that might fall into the roof, said Sharot, who has a PhD in psychology and neuroscience from New York University.
Top Broker Summit is produced by Canadian Underwriter magazine and is taking place Monday at the Ritz-Carlton across the road from Torontos Roy Thomson Hall.
Optimism bias is something developed over millions of years of primate evolution, suggested Sharot.
Overall its a good thing because if we expect the future to be bright, it reduces stress and anxiety. About four in ten people have somewhat of an optimism bias. Of the 20% who dont about half of them have clinical depression, said Sharot.
The downside is most people do not tend to take rational precautions.
If we underestimate our risk, we might not buy insurance when we should, said Sharot, author of The Optimism Bias: A Tour of the Irrationally Positive Brain.
So if you are focused on telling clients what horrible things might happen to them by accident, you might need to re-frame your message, suggested Sharot.
Highlight the gain instead of focusing on all the terrible things that can happen or the dangers out there, she said. You might say, Well, if you have this insurance, then you will be safe. There will be progress. Perhaps if you have it you will feel better.
Sharot has a lab where researchers study brain mechanisms that give rise to how people make decisions and how people think about the future. In an experiment, researchers found everyones brain did a good job of encoding good information but not as good of a job at encoding unexpected bad news.
A case in point is peoples perception of the risk their marriage will end.
Of every five couples walking down the aisle, approximately two end up splitting their assets but when you ask newlyweds about their own likelihood of divorce, they estimate it at about zero per cent and even divorce lawyers, who should know better, usually underestimate their own likelihood of divorce, said Sharot.
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Why 80% of the population may decline insurance they need - Canadian Underwriter
BOSTON--(BUSINESS WIRE)--Cerevel Therapeutics, a company dedicated to unraveling the mysteries of the brain to treat neuroscience diseases, will present new data from a Phase 1 dose-escalation clinical trial evaluating the safety, tolerability, and pharmacokinetics of multiple repeated doses of CVL-865 (formerly PF-06372865) in healthy volunteers. The readout will be presented at the 2019 American Epilepsy Society Meeting, taking place from December 6-10 in Baltimore, Maryland. CVL-865 is a novel 2/3/5-subtype selective GABAA receptor positive allosteric modulator that is being investigated for the treatment of epilepsy.
Details of the poster presentation are as follows:
Title: Safety, tolerability, and pharmacokinetics of multiple repeated doses of the 2/3/5-subtype selective GABAA positive allosteric modulator PF-06372865 in healthy volunteersAuthors: Rachel Gurrell, Mark Whitlock, Adam OgdenPoster Session #: 2.225Date/Time: Sunday, December 8, 2019 from 10:00AM 4:00PM ETLocation: The Baltimore Convention Center, Baltimore
About Cerevel TherapeuticsCerevel Therapeutics is dedicated to unraveling the mysteries of the brain to treat neuroscience diseases. The company seeks to unlock the science surrounding new treatment opportunities through understanding the neurocircuitry of neuroscience diseases and associated symptoms. Cerevel Therapeutics has a diversified pipeline comprising five clinical-stage investigational therapies and several preclinical compounds with the potential to treat a range of neuroscience diseases, including Parkinsons, epilepsy, schizophrenia and substance use disorders. Headquartered in Boston, Cerevel Therapeutics is advancing its current research and development programs while exploring new modalities through internal research efforts, external collaborations or potential acquisitions. For more information, visit http://www.cerevel.com.
Special Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements that are based on managements beliefs and assumptions and on information currently available to management. In some cases, you can identify forward-looking statements by the following words: may, will, could, would, should, expect, intend, plan, anticipate, believe, estimate, predict, project, potential, continue, ongoing or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Although we believe that we have a reasonable basis for each forward-looking statement contained in this press release, we caution you that these statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. Forward-looking statements in this press release include, but are not limited to, statements about the potential of our research and development programs and the potential attributes and benefits of our product candidates. We cannot assure you that the forward-looking statements in this press release will prove to be accurate. Furthermore, if the forward-looking statements prove to be inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time frame, or at all. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.
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Cerevel Therapeutics to Present Safety, Tolerability, and Pharmacokinetics Results From Phase 1 Trial of CVL-865 - Business Wire
A study from McMaster University has shown that traditional ways of learning anatomy remain superior to those that rely on digital media.
The research suggests that virtual reality (VR) and mixed reality (MR) are inferior to traditional physical models of learning, and have major disadvantages in cost and functionality.
The findings also support the pivotal role of stereoscopic vision the ability to perceive depth using the slightly different view from each eye in efficient anatomy learning.
The study results were published today in the journal Anatomical Sciences Education.
These newer technologies promise to provide dynamic and vivid imagery that the user can interact with for an active and self-paced learning experience, without having to enter an anatomy laboratory. Surprisingly, the evidence for this apparent advantage over traditional instructional materials is scarce."
Bruce Wainman, first author and director of the education program in anatomy at McMaster
The study of human anatomy has traditionally included cadaveric dissection and the viewing of prosections, illustrations, photographs and physical models of anatomy.
Rapid advancements in computer technology have led to many different forms of digital anatomic simulations designed to supplement, and even replace, traditional instructional materials, said Wainman.
The McMaster study compared an MR model (Microsoft HoloLens) and a VR model (HTC VIVE) derived from a physical model to the actual model. The researchers focused on overall learning performance and the effects of stereopsis by using a strategy where the non-dominant eye was covered in one test condition.
Groups of 20 undergraduate students at McMaster with no prior anatomic training learned pelvic anatomy under seven conditions: physical model with and without stereo vision; MR with and without stereo vision; VR with and without stereo vision, and key views on a computer monitor. All were tested with a real human pelvis and a 15-item, short-answer recognition test. Students were not allowed to touch any of the physical models.
The results showed that, compared to the key views on a computer monitor, the physical model had a 70 per cent increase in accuracy; the VR a 25 per cent increase, and the MR a non-significant 2.5 per cent advantage.
"At the end of the day, there was little advantage to learning from virtual or mixed reality compared to a photo on a piece of paper, and they were much worse than a solid model," said Wainman.
"We found that that when you took away the stereo vision from the virtual reality headset tested, it was even worse than learning from a piece of paper. Promoters of this technology often say it is a superior way to learn, but our research shows that isn't true."
Geoff Norman, co-author of the paper and professor emeritus of health research methods, evidence, and impact at McMaster has spent the past 20 years focused on educational research, including the last decade working with Wainman on anatomical education best practices.
"There are claims about virtual reality being better, but then you find it is not just worse, but significantly worse, and a lot worse for segments of the population who have challenges already with their stereoscopic vision," said Norman.
"We encourage more quantitative research in this area to further assess mixed and virtual reality systems prior to implementation in anatomical education programs."
Prior to primary testing, 40 undergraduate students from McMaster were recruited to obtain qualitative data regarding the optimal environment for the MR and VR models.
"When we surveyed people about how long they were willing to learn in that virtual environment, no one indicated they were able to learn for more than 30 minutes," said Wainman. "Meanwhile, we have students who study in the anatomy lab six or seven hours a day looking at human material.
"We're not thinking about the technology so much as what is the best way to learn. We want technology to be in the service of education, and not the other way around."
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Traditional ways of learning anatomy remain superior than virtual and mixed reality models - News-Medical.net
As planned, Krug was driving the play from the back end, standard fare in 3-on-3 overtime hockey. OT turns hockey into a game of slingshot. And the Wild were about to be shot.
Im just trying to be open right away, said Bergeron, reciting how the play was designed. We had a play set up on that particular instance.
Per design, Krug was supposed to toss the puck to Bergeron, who in turn would bump it back to Krug, who in turn would laser a pass to Marchand breaking wide on the wing. Add a little travelin music ... and away we go.
Its precisely that play that the Wilds three skaters anticipated in their man-to-man coverage. Zach Parise would force Krug to give it up near mid-ice, and the two back defenders, Brad Hunt on the right and Luke Kunin on the left, would pick up either Bergeron or Marchand.
If the play were covered properly, it might force a low-percentage shot from outside, or perhaps force Marchand to circle back out of the zone with the puck and try to generate a different entry, recreate the slingshot.
But a funny thing happened on the way to the forum. Parise eased off his coverage of Krug in the neutral zone, opening wide the center of the ice, with a Waze-like track there for Krug to follow straight down Broadway. Parise never had chance to recalculate.
Up on the ninth floor, in his customary perch, team president Cam Neely spotted the open path.
I was a little surprised by the two defenders, how wide they got, a diplomatic Neely said Sunday, following a World Trade Center event at which he unveiled the clubs new third sweater. Then I was thinking, I hope Torey sees the opening there. Thankfully, he did, and he turned on the jets. You always wonder, if theyre seeing at ice level what were seeing on the ninth floor, right? Its all a little slower when youre watching from up there.
Neely, not unlike the Wild defenders, was thinking, OK, Krugs going to pick it up and give it one of his wingers, March or Bergy, on the fly, so they can have speed on the entry.
Instead, Hunt and Kunin morphed into ... wait for it ... Laurel and Hardy, and Krug took all the space they offered. As he zipped down the slot, all three Wild skaters waved their extended sticks his way, with astonished goaltender Alex Stalock aware of the doom about to be dropped at his doorstep.
I mean, not often you go end to end, right? said Neely. Not even on 3-on-3, when you think you might be able to do a little bit more.
Krug read the play perfectly, as if he, too, were sitting in a comfy roller chair on the ninth floor. He was not near full flight as he left the defensive zone.
Came up the left side a little bit to mess with Parises gap, he recalled. Once I took a couple of hard strides I realized I could beat him, parting of the sea. Marchy and Bergy drew some attention as well, and all of a sudden I was in alone.
As Krug closed down the slot and angled toward the right post, Stalock dropped to his knees. Just as he neared the blue paint in the crease, Krug shoveled off a backhander and the puck squeezed through the tenders pads and bled over the line.
The clock frozen with 2:19 left in overtime. Krug wasnt aware hed won it until he curled out of the right offensive corner and saw his teammates spilling over the boards like schoolboys set free at the recess bell.
I heard the crowd,said Krug, who looked akin to drum major leading a marching band during his goal celebration. Then I heard Bergy and Marchy scream, so all of a sudden someone is off the bench and hugging me. Right there, when you score those goals, its just natural emotion and energy.
Somewhat overshadowed in the drama was that David Krejci, both times on velvety feeds from Bergeron, scored a pair of third-period goals in span of 48 seconds, erasing the Wilds 4-2 lead. On both strikes, the Bruins had pulled goalie Tuukka Rask for an extra attacker. On the 4-4 equalizer, which had the Bruins skating with a 6-on-4 advantage, Bergeron first had to race back to the bench to replace a broken stick. He returned and fed deep on the wing for Krejci to hammer home a one-time slapper from a sharp angle.
Combined, including the pair of Krejci strikes and then Krugs wizardry, the Bruins transformed standard-cut NHL hockey into what felt more like the stuff that is played on streets and ponds. It lacked only someone yelling, Car! or a black lab chasing down a puck that had skittered over a snowbank.
Everyone in the crowd of 17,850 should have been offered a cup of moms hot chocolate as they headed home.
Having the celebration after the [Krejci] goal that tied the game, those are great feelings, said Krug.
Those are moments that bring a team together throughout a season. That group of guys on the ice take a lot of pride in making things happen. To come back and celebrate on the bench with those guys, and see how excited they are, thats a special thing. Those are moments that bring a group together, and well try to embrace it.
Kevin Paul Dupont can be reached at kevin.dupont@ globe.com. Follow him on Twitter @GlobeKPD.
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Anatomy of a game-winner: How Torey Krug went off-script to lift the Bruins - The Boston Globe