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SXSW 2020 Interview: Maria Finitzo on Identifying the Anatomy of Gender Inequality in The Dilemma of Desire – The Moveable Fest

At the start of making The Dilemma of Desire, Maria Finitzo and her producers has convened a meeting of the minds in Chicago, bringing together dozens of women from all walks of life to openly talk about what had long been a societal taboo their clitoris. The filmmaker had already been filming with Sophia Wallace, a multidisciplinary artist who had been trailblazing in fostering this conversation at large with her project Cliteracy, providing basic knowledge on female genitalia where sex ed had long failed, but when it took until 1998 for scientists even to be able to present a full structure of the clit since no proper study had been done before, Finitzo had to wonder whether the subject was still so obscure even amongst women that it might not be meaningful to address with a full feature film.

At one point, one of the women in the room said, I have hungered for this conversation. We never talk about this, recalls Finitzo. And it was quite wonderful because it validated my hunch that this was a film that would resonate with a wide audience.

In The Dilemma of Desire, Finitzo channels the energy of that conversation into a brisk, entertaining and edifying cultural history of the clitoris, making the convincing case that its absence in the public discourse, woefully underrepresented, if at all, in scientific research studies in relation to its male counterpart and largely made to feel as if its too private to talk about, has stymied the progress towards achieving full equality for women. Although the joke has always been that men cant find the clitoris, the punchline has been particularly cruel to women as Finitzo illustrates when in the opening moments of her film, Dr. Stacey Dutton, an assistant professor of biology at Agnes Scott College, has trouble locating it as she flips through the pages of Grays Anatomy, lamenting Its almost like they wiped womanhood out of the text.

Finitzo puts a face to how damaging this slight has been to society as a whole, following the work of Dr. Dutton; Dr. Lisa Diamond, a professor of psychology and gender studies at the University of Utah, Ti Chang, the co-founder of the female-driven sex toy manufacturer Crave, and Wallace, whose efforts can seem provocative merely when presenting basic facts, but widens her scope to include a collection of young women for whom more knowledge about sex at an early age wouldve changed their lives radically. The Dilemma of Desire introduces audiences to Coriama, Jasmine, Becca, Unmia and Sunny, all of whom can be seen speaking confidently to the camera now about their experiences, but describe how undermined theyve been throughout the years by being misinformed or outright misled about how their bodies work and the ripple effect that uncertainty has had on attaining personal and career goals.

The Dilemma of Desire can be seen bringing light to how knowledge is power in any number of ways, with effervescent subjects competing with neon-lit signs projecting Wallaces 100 Natural Laws throughout for what shines brightest, and Finitzo is able to acknowledge the awkwardness around the subject with good humor while never diminishing its importance. Although the films premiere was postponed when its intended bow at SXSW was cancelled as a result of the coronavirus, The Dilemma of Desire just cant be denied and in that spirit, Finitzo and I spoke about how she was inspired to make the film, bringing abstract concepts about patriarchal society and female empowerment into focus and why the subject seems more relevant than ever.

How did this come about?

It came from a lot of different places. I have two kids and one of them is a daughter and I remember when she was in high school, being appalled at the dangerous landscape she was navigating. I wasnt somebody that thought, Oh, my daughter has to wait until she gets married to have sex or any of that Im pretty pragmatic about that, but I was stumped by the fact that we tell girls and women that they can go out and hook up when in fact they really cant because the patriarchal system that punishes them for behaving how men are still behaving is still in place. And I remember reading a book in 2012 called The Science of Female Sexual Desire, What Do Women Want, written by a really great journalist Daniel Bergner. He had gone all over the country interviewing scientists who were studying female desire with women as subjects, which in itself was unusual, and at the end of the book, the scientists all said, Women have as robust a sex drive as men. Theyre simply told lies about it to reinforce patriarchal culture.

That really struck me as a starting point for a film about all the things that get in the way of women having agency over their desire and how that looks in their own life. I found Sophia Wallace because her work Cliteracy Under Natural Laws just blew me away because it was all so true and it was very eye-opening. I remember thinking that she was the woke person I had ever met and she remains the most woke person I ever met so we initially started filming with [her], Stacey Dutton, and Lisa Diamond, three of the experts, and Gordon Quinn, whos the creative director of Kartemquin Films, said to me, you need to find women who are just everyday women, who are not scientists or artists who are really ensconced in this topic because these women easily discuss sex. You need to find everyday women to see how what theyre studying resonates in their everyday life.

You really notice the racial and cultural diversity in the group that you find. Were you looking for certain experiences to follow?

What youre looking for when you go to put everyday people in your film is people for whom the experience of being in the film will be one they enjoy, and I believe that if I as a filmmaker set up the right environment, then everyone has a story and if Im a good filmmaker, everyones story will be powerful. And I didnt want this to just be a film about white, heterosexual, middle class women who have bad sex. I wanted it to really try as much as you can in one film to really include a wide range of voices, so thats what I went looking for and it worked out really well. [For instance] Coriama [a self-described queer African-American pleasure priestess], I went out to a number of people and said, Give me the names of some women that work in this space and bringing her into the film was a wonderful experience, for both the film and also for me in getting to know her and the work that she does in communities of color and the LGBTQ community, so it was important to me to have a wide range of voices.

One of the things that was also really helpful was to have Sophia Wallaces work, The 100 Natural Laws as a thematic ladder upon which I could pull together all of these different scenes. Because a lot of Sophias work is text, I wanted that text to come alive because its a film and it was really exciting to see how the laws are grounded in the real experience of women. Thats why I think they work so well throughout the film, and it was really fun working with the editors and some of the designers to say Okay, if the law emotionally punctuates the end of this scene, how does it do that? Its always an emotional punctuation, so it either has to reinforce something very serious or give you a reason to smile and laugh, like [the law] Can you draw a clitoris? And [the women in the film are] all laughing and it makes people [in the audience] laugh. So I really loved bringing that element into the film.

One of the difficult balancing acts of the film seems to be making this fun but not trivial, which you get across as early as the first scene of the film. Was that a challenge?

It was very hard because this wasnt a film that was like a typical narrative film, [where like] a scrappy underdog sports team makes it to the playoffs and you follow that story and they have the ups and the downs and then they finally either win or learn a bigger, important life lesson. Thats an easy narrative to follow and this film is an essay about female desire and its relationship to womens equality. Still, I think humor is really important in a movie, so some of the scenes have some humor in it, but theyre also dealing with really fundamental issues to personhood and citizenship, so I didnt want to trivialize that. So much of what happens [in popular culture representation] around female desire and pleasure is embarrassment, so people giggle or they laugh and I really didnt want that to be the experience that people had.

We start off telling you this is what the clitoris looks like and by the middle of the film, Sophia Wallace tells you its a symbol, a metaphor for inclusion, that all bodies are entitled to the pleasure theyre capable of and it belongs to everyone, and then it becomes a symbol for liberation, so thats the arc that the clitoris has to travel and I wanted that sense of empowerment, so while I want you to enjoy my film, I dont want you to leave the film bummed out because we deal with some very serious issues. I wanted you to come away with a sense of joy and a sense of potential for what our world might look like if all of us were entitled to live our lives within whatever capability we could. This isnt really a film about the clitoris, its about power and how power is easily taken when the lie is replaced with the truth, so when you deny women the knowledge of their bodies, youre cutting them off from a vibrant source of power in their lives.

You include some brief snippets of footage from the Brett Kavanaugh Supreme Court confirmation hearings was it interesting to be putting this together at a time when the inequality between men and women was made so clear?

Yeah, I started the film in 2016 before Trump was elected, and while we were all walking around a little worried, none of us couldve imagined what would happen. After 2016, it became how can you make this film during this time without acknowledging what is going on I wanted to do that, but I also did not want to make it a film about Donald Trump. So we had it in there at various times in different ways and then everybody said, No, take it out, take it out, and when it is finally mentioned [in the film now], its only enough for you to understand the context of the times.

What became clear to me as a filmmaker is how much more urgent the film seemed. I grew up in the 60s and 70s during womens liberation and I also grew up before Roe V. Wade and who wouldve thought we would now at this point be at a time in our lives where all of the reproductive rights that women had gained are now being taken away? To me that felt more and more urgent that we had gone backwards in time. Its not enough to say to young women, sure, you can sleep with whoever you want. Thats not really empowering. Thats just setting them up to get clobbered. If we really want to change the world, we have to find a way to dismantle a patriarchal system that is meant to be violent, and as Coriama says towards the end of the film, the only way to get out of it is to get rid of the fucking system.

The films premiere, scheduled to be at SXSW, has been put on hold because of the coronavirus, but when youve worked on this project for so long, whats it like to get to the finish line?

It felt great getting to the finish line because Ive had this film in my head visually for about six years, so finally when it all comes together and you work with a team of really talented people the composer and the editors and all the people who do your color correcting, its beautiful to finally see it. What Im missing right now is the experience of showing the film with an audience live because thats also a whole other incredible experience. It just changes everything, so Im really, really hoping to at some point in the future to be able to share this film with an audience.

The Dilemma of Desire does not yet have U.S. distribution. A schedule of future screenings is here.

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SXSW 2020 Interview: Maria Finitzo on Identifying the Anatomy of Gender Inequality in The Dilemma of Desire - The Moveable Fest

Grey’s Anatomy Spoilers: Will the Truth Come Out? – TV Fanatic

The doctors are away and ready to play.

That is what the promo for Grey's Anatomy Season 16 Episode 19 teases, and we are so ready for it.

ABC also dropped a press release to give fans a taste of what's to come.

"Love of My Life" - Richard preps to present his PATH pen at the LA Surgical Innovation Conference but becomes distracted by his issues with Catherine.

Maggie and Teddy run into people from their past at the same conference, while Hayes relives moments from when he met his late wife, on an all-new episode of "Grey's Anatomy," THURSDAY, MARCH 26 (9:00-10:01 p.m. EDT), on ABC. (TV-14, DS)

Episodes can also be viewed the next day on demand and on Hulu. "Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Chandra Wilson as Miranda Bailey, James Pickens Jr. as Richard Webber, Kevin McKidd as Owen Hunt, Jesse Williams as Jackson Avery, Caterina Scorsone as Amelia Shepherd, Camilla Luddington as Jo Wilson, Kelly McCreary as Maggie Pierce, Kim Raver as Teddy Altman, Giacomo Gianniotti as Andrew DeLuca, Greg Germann as Tom Koracick, Chris Carmack as Atticus "Link" Lincoln and Jake Borelli as Levi Schmitt.

Guest starring is Debbie Allen as Catherine Fox and Richard Flood as Cormac Hayes.

"Love of My Life"was written by Kiley Donovan and Andy Reaser, and directed by Alison Liddi-Brown.

It sounds like another bottle episode is on the horizon, and there's nothing wrong with that, so long as it benefits the arcs of the respective characters.

Richard and Catherine's issues taking center stage should allow them to finally move on with their lives. There's a slim chance they could get back together, but it seems the love between them has fizzled out.

Maggie and Teddy being out of town and meeting people from their past should present some fun moments for both characters.

Maggie recently broke up with Jackson, and based on the official trailer for the episode, she will find someone new to cosy up to.

As for Teddy, she's been cheating on Owen with Tom and feels terrible about it. Something is bound to happen on the trip that will make her come clean to Owen about her infidelity.

Whether that will result in the implosion of their relationship, we don't know, but we need some movement on that front.

Hayes opening up about his past could be exciting.

We've heard him talk about his wife to Meredith, but whether he will be opening up to her or another character is not something that has been confirmed.

That being said, it does seem like Meredith is not on the trip.

The producers really need to make Richard Flood are more permanent cast member because Hayes one of the best on the show. There is a lot of potential for his character.

Have a look at the full trailer for "Love of My Life," and hit the comments with your thoughts on it.

Grey's Anatomy airs Thursdays at 9/8c on ABC.

Remember you can watch Grey's Anatomy online right here via TV Fanatic.

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Paul Dailly is the Associate Editor for TV Fanatic. Follow him on Twitter.

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Grey's Anatomy Spoilers: Will the Truth Come Out? - TV Fanatic

Friends? The Office? Grey’s Anatomy? Watch them all on MENA’S STARZPLAY! – Startup MGZN

The entertainment fiesta never stops on STARZPLAY, the leading subscription video on demand (SVOD) service in the MENA region, which continues to provide its million-plus subscribers with premium content. With people spending more time at home now, this is the perfect opportunity to binge-watch your favorite shows. From full box sets of the best shows to the latest must-watch Hollywood blockbusters as well as continuing hit titles, there is something for everyone.

Watch the cult classic sitcom,The Big Bang Theory, which remains a top choice for comedy fans, and especially popular among STARZPLAY subscribers, who had the chance of watching the series finale on the platform at the same time it aired in the US last May. So, it may be time for fans to re-visit their favorite scientist pals (and Penny!) and enjoy all 12 seasons of the Golden Globe and Emmy awards winning series, only on STARZPLAY.

STARZPLAY is also home to the much-loved American sitcomThe Office, the mockumentary on a group of typical office workers where the workday consists of ego clashes, inappropriate behavior, and boredom. Fans can watch all the nine-seasons of the hilarious documentary-style TV series that tells stories about contemporary work culture in the most hysterical way.

Fans of the epic historical dramaVikings can watch every new episode of the sixth and final season of the epic action-adventure, that has turned into a worldwide phenomenon,exclusively on STARZPLAY. And for those who are yet to delve into the shows fascinating world, all previous 5 seasons are currently available on the platform.

While the world celebrated the 25thanniversary of the launch ofFriendslast year, the show remains one of the most beloved and popular sitcoms in TV history, STARZPLAY subscribers can binge-watch all ten seasons of the classic comedy through the platform anytime, anywhere and from any device, and share this joyful experience with their own friends.

Fans of the American television medical dramaGreys Anatomycan watch every new episode of the fifteenth season starting March 28 on STARZPLAY. Watch how surgical interns and their supervisors embark on a medical journey where they become part of heart-wrenching stories and make life-changing decisions in order to become the finest doctors.

Available in 20 countries across the Middle East, North Africa and Pakistan, with more than 10,000 hours of content including premium movies, exclusive and Arabic series, STARZPLAY has also secured its place as the number one player in the MENA region.

As shared in a press release.

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Friends? The Office? Grey's Anatomy? Watch them all on MENA'S STARZPLAY! - Startup MGZN

From 15 years of heroin addiction to becoming a neuroscience lecturer – The Irish Times

Every morning psychology lecturer and author Brian Pennie wakes up very early and does five things: meditation, affirmation, visualisation, inner child work and gratitude. It makes up an acronym mavig and he swears by it. He does these things every morning, he says, whether itsWorld War III orthe coronavirus.

Seven years ago, when he was in the throes of a serious heroin addiction, Pennies mornings looked quite different. He would awake to an overly loud alarm playing In the Morning by Razorlight, after which a couple of benzos and some gear would get him out of bed. I had no emotional world. I had no spiritual world. That was all gone . . . My brother, who I lived with, says he still gets shivers when he hears that song.

Pennies memoir, Bonus Time, tells the story of his journey through a 15-year heroin addiction on to a post-recovery career as a speaker, neuroscience lecturer and PhD student.

All addiction, Pennie says, has its roots in trauma. His own trauma, he now believes, stems from an operation he had as a baby. In those days, operations on infants were misguidedly carried out without anaesthetic and, with what he knows now about psychology, Pennie reckons this might explain the feelings of unease and anxiety he carried with him through his childhood and into adulthood.

I still have weird feelings around bodily sensations, he says. Thats my Everest. If you said to me, Ill give you a million euros, Brian, if you can feel your pulse for a minute, Id probably do it for a million quid but I stillhave negative associations around my heartbeat and my pulse. He rubs his side. Im rubbing my scar as I talk about it . . . I imagine for the first year of my life I had horrible bodily sensations; I imagine that as a baby I could feel my heartbeat, I could feel the pulse and I associated that with pain.

Throughout his childhood he was restless and agitated. I had sirens in my head, he says. I was just such a worrier. I worried about my parents dying. I had huge fear of death and a huge fear of losing people close to me.

Drugs offered him relief from this. His first drug, he says, was a cigarette. He remembers it very clearly. All my friends were smoking and I remember thinking they were idiots . . . but something just shifted one day and one of my mates said, I love the head buzz you get off that and that piqued my interest. And within weeks I was smoking hash.

Pennie grew up in working-class Ladyswell in Blanchardstown, but went to a posher school than many of his friends, St Declans in Cabra. He never felt he fitted in there, he says, and in an attempt to do so he styled himself as a drug dealer. They called me Penpusher. I was such a mediocre drug dealer. I wasnt hard enough to be a drug dealer in [Ladyswell], but I was hard enough for St Declans. He laughs. Which is pathetic and I see that now.

He wanted to be cool. He and his best friends were obsessed with the music and poetry of Jim Morrison. Jim was into a drug called Peyote so we thought we have to do as much acid as we can to be like Jim Morrison and expand our minds.

Did it expand their minds? He laughs. I was completely deluding myself. I just liked the idea of expanding my mind . . . We were into Kurt Cobain as well . . . We wanted to join the 27 Club [musicians who died at the young age of 27], me and my friend Barry. Wed actually say that to each other . . . Were going to burn out, not fade out. Losers fade out. It was just a rationalisation to do more drugs.

When he was 16, Pennie tried methadone. He didnt even know that it was a heroin substitute, he says, though after I wrote the book the friend that I did it with said, You f***ing did know, you mad thing. Memories are crazy.

When he was 17, he did heroin. It was amazing, he says. Even talking about it now I feel a sense of calm. I got a lovely stillness in me . . . It was amazingly powerful and beautiful. I revered it like a god from the heavens.

Since getting clean, he says, he has discovered he can conjure up a purer less artificial version of that still and timeless feeling he got from heroin from meditation. At the time, however, he and his friend Barry (not his real name) fell into serious addictions. Barry, he tells me, is still in addiction and is homeless.

Pennie never saw himself as a real addict. He managed to keep a job in the graphics department of a printing company, and to keep a veneer of a functionality for 15 years while maintaining a serious addiction and a second job as a not particularly competent drug dealer. I wasnt as unusual as I thought I was. People stereotype the addict as someone on the dole, but a lot of people turn up [at methadone clinics] in vans and have jobs.

The fact Pennie managed to keep his job for so long feels miraculous given the reality of his addiction. He was liked by his colleagues and good at his job when he did it, he says, and he thinks some of them mistook his issues for a more socially acceptable addiction to alcohol. But his problems were increasingly obvious.

He describes his typical workday: I would wake up in the morning and there was always stress from the night before. I owed out money. I didnt get paid. I didnt have enough drugs for the day. I would always have a little bit of something to keep me out of the sickness, so I wouldnt be overly anxious at work. Id be frantically making phone calls during the day, and I would probably make up some story to say I had to go to thecredit union or something . . . I had a lot of bulls**t happening to give me excuses to get out of place and go and score some gear. Id come back and smoke it in the industrial estate, come back into the job. Id be looking a lot better now, because I wasnt struggling with anxiety anymore, but I would look stoned. I would probably goof off, on the chair.

He regularly fell asleep at work. After work Id go and try to collect some money, pay the dealers. In the earlier stages, it would have been just about getting more heroin, more benzos just to get nicely stoned. But in the latter years, no matter how many drugs I did, it just brought me to baseline or below baseline.

When the heroin stopped giving him a high, he formulated a plan to move to Afghanistan where he thought it would be stronger. Seriously. I was looking up flights and all, he says. From a neuroscience perspective my body was just in a state of agitation, my nerve endings were always agitated. I just wanted to ease the agitation that was in my body but the more drugs I did, the more agitated I became. I was like a snake trying to eat its own tail.

When his mother discovered piles of old methadone bottles under his bed, he managed to convince everyone he was nearly recovered from addiction rather than supplementing a long-standing methadone prescription with heroin and tablets. He likens himself to a chameleon, changing to fit whatever world he was in. At one point he might play golf with colleagues. At another he might watch a man who had just extracted heroin from his rectum, hand it to him with his faeces-covered hands. I thought, this is not who I am. I dont belong here. Hes a dirt ball, Im not a dirt ball.

It was only when he was finally suspended from work that he sought help. He was told by his doctor that he needed to wean himself off benzodiazepine before hed be allowed into a heroin detox centre and, against all advice, he decided to stop taking the tablets overnight. This is not recommended by the experts for good reason.

After a trip to AA with his sister I fell asleep on her shoulder, smelling of vodka he returned to his flat where, a few nights later, he had a withdrawal related seizure. He bit his tongue down the middle and ended up in hospital. That was the moment when the world completely changed. I was never really going to get clean until I had a seizure . . . My self identity was, I cant cope with anxiety, I need to take heroin. The seizure cracked that shell, and it just opened the door to look at the world in another way. It just broke me mentally, emotionally and physically. It was like I was dead inside afterwards. There was nothing inside of me.

He didnt even have the strength to score drugs at that point, which meant that several weeks later, the benzodiazepine was out of his system and he was in a detox centre coming off heroin and methadone. While there he began reading about mindfulness and psychology and eastern philosophy. He kept a diary, and wrote several overly earnest letters to his family. I genuinely believe the most clarity I ever had in my life was when I was in detox, he says.

This was difficult for some members of his long-suffering family to take. The addict mind kicked in and I thought I was a sage, he says. I told my sister, I have a secret. Ill tell you about when I get out, not realising that I had put them through torture for years. A few weeks after they thought I was dead Im sending them letters [saying things like], eat strawberries and really feel the strawberry.

Nonetheless, he embraced learning and never let go of it. From a neuroscience perspective, if we have that dopamine hit drug, drug, drug, drug, drug and you get clean and dont hook that little dopamine hit on to something else, you are going to feel crap. And what do you do when you feel like crap? You use drugs. I think what saved me was I hooked my dopamine receptors on to a new drug and that drug was learning. I think its really important to try to find what is the positive new drug for someone, and over time help them find balance. Ive never found balance. Im still obsessed about learning. Thats okay. We call it drive. We dont call it addiction anymore.

Since then, Pennie has completed a degree in psychology in NUI Maynooth, is studying for a fully-funded PhD at the institute of neuroscience in TCD, and slowly building a reputation as a speaker and a lecturer. Hes interested in the space where eastern philosophies of mind intersect with western psychology, and over the course of our chat, he quotes thinkers like Anthony de Mello, Eckhart Tolle and Viktor Frankl.

Things havent always gone smoothly, he says, but he insists that hes the happiest person I know. He is very close with his family. He has come up with 200 tools for life, at first to help himself, but which he now imparts to clients in one-on-one sessions and to rooms full of people as a speaker. He lectures in the neuroscience of mindfulness at UCD and the neuroscience of addiction in TCD. In his spare time, he has been interviewing business leaders and public figures about their own strategies for life, and is hoping to turn his findings into another book.

He talks about the importance of affirming your own values (his include boldness, connection, open mindedness), and visualising the things you want to achieve. When he got a box of his books from the publisher, he tells me he was so excited he hurt his hand opening the box. Ive been as honest as I could. My main mantra in life is, be true to your wonderfully weird self. I just let the truth out.

Continued here:
From 15 years of heroin addiction to becoming a neuroscience lecturer - The Irish Times

A New Drug May Be Able to Ease the Side Effects of Medication Against Severe Depression – Technology Networks

About one in five Danes are affected by depression at some point in their lives. The severe depressions may be treated with the so-called tricyclic antidepressants, an antidepressant drug that is more effective than the drugs used for mild and moderate depressions.

But unfortunately, the tricyclic antidepressants also have a downside: significantly more and more serious side effects. So serious that many people stop taking the drug and thus receive no treatment for their depression.

Now, researchers from the Faculty of Health and Medical Sciences at the University of Copenhagen, in collaboration with Lundbeck A/S and the National Institutes of Health in Baltimore, have discovered a substance that may solve that problem.

We have discovered a substance, Lu AF60097, that works in a different way from the ones presently in use. If the new substance works, it may help the existing drugs get rid of the serious side effects, says Professor at the Department of Neuroscience at the Faculty of Health and Medical Sciences, Claus Juul Lland.

Therapeutic effect without side effects

Serotonin is a so-called neurotransmitter, a chemical substance found in the brain. In a person with severe depression, the level of serotonin is very low. Antidepressant drugs make adjustments to get a higher level of active serotonin.

The antidepressants we use today work by going in and binding to the same site as serotonin on the serotonin transporter (SERT). The antidepressants block the return transport of serotonin and thereby also the removal of the active serotonin. But such blockage requires a relatively large dose of the antidepressant substance. And with the tricyclic antidepressants, that causes some serious side effects, says Claus Juul Lland.

The side effects can be anything from life-threatening heart problems to severely dry mouth, visual disorders, development of mania, weight problems and digestive challenges.

The substance discovered by the researchers binds to another site on SERT: the allosteric site. When a substance binds to the allosteric site rather than the same site as serotonin, it is possible to regulate the function of the serotonin transporter instead of completely blocking it.

In this case, we have shown that when we bind this substance to the allosteric site while giving the tricyclic antidepressant, we can amplify the binding of the antidepressant substance. Therefore, we can use a much smaller concentration of the antidepressant substance. It might cause fewer side effects, but have the same therapeutic effect, says Claus Juul Lland.

From concept to drug

The researchers have, over a long period of time and in several rounds, screened a number of substances from Lundbecks drug library to find a substance that had a sufficiently strong link to the allosteric site to make it possible to study the pharmacological effect. With Lu AF60097, they finally succeeded.

But there is still a long way to go before the substance can be used as an actual drug. The researchers have shown that a substance that binds to the allosteric site can have this pronounced, pharmacological effect in cells and in rats. From here, it is up to the pharmaceutical companies to develop substances that may have the same effect in humans.

We have taken the first step. But perhaps also the biggest. We have shown that the concept works. If it also works in practice, hopefully in the future it can be used to treat people with severe depression.The study The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter has been published in Nature Communications.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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A New Drug May Be Able to Ease the Side Effects of Medication Against Severe Depression - Technology Networks

Neuroscience Antibodies & Assays Market Trends, Strong Application Scope, Key Players, Growth Overview and Forecast by 2027 – Jewish Life News

The latest Neuroscience Antibodies & Assays market study offers an all-inclusive analysis of the major strategies, corporate models, and market shares of the most noticeable players in this market. The study offers a thorough analysis of the key persuading factors, market figures in terms of revenues, segmental data, regional data, and country-wise data. This study can be described as most wide-ranging documentation that comprises all the aspects of the evolving Neuroscience Antibodies & Assays market.

The research report provides deep insights into the global market revenue, parent market trends, macro-economic indicators, and governing factors, along with market attractiveness per market segment. The report provides an overview of the growth rate of Neuroscience Antibodies & Assays market during the forecast period, i.e., 20202027. Most importantly, the report further identifies the qualitative impact of various market factors on market segments and geographies. The research segments the market on the basis of product type, application, technology, and region. To offer more clarity regarding the industry, the report takes a closer look at the current status of various factors including but not limited to supply chain management, niche markets, distribution channel, trade, supply, and demand and production capability across different countries.

To get sample Copy of the report, along with the TOC, Statistics, and Tables please visit @https://www.theinsightpartners.com/sample/TIPBT00002234/

Neuroscience involves the study of nervous system, where the research is completely relies on assays and antibodies. These antibodies and assays are specific that helps to identify and examine reactions on the cellular, biochemical and molecular level. Antibody-based approaches are used for the localization, isolation and characterization of targeted proteins that majorly used in the cellular and molecular neuroscience. On the other hand, the use of assays provide an efficient, valuable solution for determination of critical targets that are involved in synaptic signaling, neural development and neurodegeneration.

MARKET DYNAMICS

The global neuroscience antibodies & assays market is anticipated to grow with a significant rate in the coming years, owing to the increasing incidence of neurological disorders, growing pharmaceutical & biotechnology industries and increasing investments in neuroscience research. On the other hand, increasing research & development activities are projected to offer novel growth opportunities for the players operating in the neuroscience antibodies & assays market, in the coming years

Key Players

The research provides answers to the following key questions:

The study conducts SWOT analysis to evaluate strengths and weaknesses of the key players in the Neuroscience Antibodies & Assays market. Further, the report conducts an intricate examination of drivers and restraints operating in the market. The report also evaluates the trends observed in the parent market, along with the macro-economic indicators, prevailing factors, and market appeal according to different segments. The report also predicts the influence of different industry aspects on the Neuroscience Antibodies & Assays market segments and regions.

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It is extremely vital to have an impartial understanding of market opinions for a strategy. Our insights provide a keen view on the market sentiment. We keep this reconnaissance by engaging with Key Opinion Leaders of a value chain of each industry we track.

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Our research ranks investment centers of market by considering their future demands, returns, and profit margins. Our clients can focus on most prominent investment centers by procuring our market research.

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Neuroscience Antibodies & Assays Market Segmented by Region/Country: North America, Europe, Asia Pacific, Middle East & Africa, and Central & South America

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The Insight Partnersis a one stop industry research provider of actionable intelligence. We help our clients in getting solutions to their research requirements through our syndicated and consulting research services. We are committed to provide highest quality research and consulting services to our customers. We help our clients understand the key market trends, identify opportunities, and make informed decisions with our market research offerings at an affordable cost.

We understand syndicated reports may not meet precise research requirements of all our clients. We offer our clients multiple ways to customize research as per their specific needs and budget

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Neuroscience Antibodies & Assays Market Trends, Strong Application Scope, Key Players, Growth Overview and Forecast by 2027 - Jewish Life News

IMMERSION NEUROSCIENCE INDEX REVEALS THE PUBLIC CRAVES DIRECTION FROM ITS ELECTED LEADERS, NOT CELEBRITIES, DURING A CRISIS – Broadcasting & Cable

Immersion Neuroscience, the worlds most advanced predictive software company unlocking neuroscience to measure what people love, recently announced a new Immersion Index revealing people's reaction to celebrities vs. elected officials communications about the current COVID-19 pandemic.

Immersion researched the most effective way to share information with the public about coronavirus. This new study compares celebrities and their social media messages with elected officials.

The best way to determine if communication is effective is to measure how well it "sticks" in the brain. Science has established that when the brain is immersed in information, it is remembered, shared with others, and acted on. Highly immersive information is what will reduce the spread of the coronavirus and save lives, said Dr. Paul J. Zak, Founder of Immersion.

The research study: Immersion asked participants to turn on their Apple watches or other wearable sensors and emailed them six videos to view online. The videos ran for one-and-a-half to two minutes and featured President Trump; Vice President Pence, who leads the White House Coronavirus Task Force; Dr. Anthony Fauci, who leads the National Institute of Allergy and Infectious Diseases and is a member of the Coronavirus Task Force; Georgia Governor Brian Kemp; singer Cardi B; and actor and former governor of California Arnold Schwarzenegger, all speaking about the coronavirus outbreak.

The study revealed that communication about coronavirus by government leaders is significantly more effective than a celebrity rant or an offbeat video with miniature horses, for example.

The Immersion platform aggregated neurologic responses and returned an average Immersion value from 1-10 for each video.

Immersion Index results for communication effectiveness are:

Vice President Pence generated neurologic immersion that was 48% higher than the next most immersive speakers, a tie between President Trump and Governor Kemp. Dr. Fauci was a close third at 53% less immersive, while Arnold and Cardi B were at the bottom of the list at 61% and 64% less immersive than Mr. Pence.

The results show that fact-based videos from elected officials, delivered without theatrics were significantly more immersive, meaning these are more likely to motivate actions by citizens.

We salute celebrities for reminding the public to be safe. But, when times are tough, this study shows that brains know that experts provide the most valuable information. If you ask people which videos they "like" or find "entertaining," they will choose the stars over the experts. Extensive research has shown that "liking" has no relationship to what people do. In this time of crisis, action is what matters. That is why measuring neurologic immersion is so important, said Immersion CEO Scott Brown.

Fifteen years of peer-reviewed research has proven that when the brain produces a specific set of unconscious responses called "immersion," it identifies an experience as valuable.

Immersions proprietary solution and software is the world's most accurate way to measure the brain's unconscious emotional responses to virtually any type of content whether its video, music, live events, training, educational resources and more. Developed by distinguished research scientists, Immersions simple to use and scalable predictive SaaS platform democratizes neuroscience so that anyone can measure what people love at scale.

The Immersion platform is unique in its ability to perform distributed neuroscience which becomes essential at a time when the world is sheltering in place. Immersion measures brain responses any place that people are using a mobile app that sends data to cloud servers. Algorithms developed by Immersion scientists infer brain activity from a small wearable sensor.

To learn more about Immersion, visit http://www.getimmersion.com.

For more information, contact:

Andrew Laszacs

Bob Gold & Associates

310-320-2010

immersion@bobgoldpr.com

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IMMERSION NEUROSCIENCE INDEX REVEALS THE PUBLIC CRAVES DIRECTION FROM ITS ELECTED LEADERS, NOT CELEBRITIES, DURING A CRISIS - Broadcasting & Cable

Ahead of switch to online classes, the future of hands-on curricula remains unclear – The Daily Northwestern

Following University President Morton Schapiros email announcing the switch to online classes until further notice, many students with hands-on majors said they were confused as to how the transition will take place.

Unlike lectures for humanities classes, which can be held more easily over Zoom, the lesson plans for many music, theater, dance and art classes, as well as STEM classes requiring labs, remain unclear. Few students said they have received concrete plans from their schools and professors yet.

Bienen, Communications students have to get creative

Bienen sophomore Josh Kuhn said he wasnt surprised by the Universitys choice but he was disappointed with their decision to cancel classes. For Kuhn, a voice major, online instruction poses a major problem.

All of us voice majors, instrumentalists, orchestra, band we are all here for the specific lessons with professional teachers and were here for the ensemble, said Kuhn. We cant take those online.

The Bienen School of Music announced the cancelation of all concerts and chamber music activities scheduled through April 27 on their coronavirus site. However, individual lessons will be taught remotely through Zoom, according to the website. If the University decides to allow students to return to campus for the later portion of Spring Quarter, the major ensembles will offer one concert each, as currently scheduled.

Still, Kuhn said the decision to host individual lessons concerns him.

You cant hear the sounds correctly for individual lessons it just isnt going to work out, Kuhn said.

Moving onward, Kuhn said he is going to talk to his parents over Spring Break about what to do but that he is considering taking a quarter off school and then re-enrolling during the summer.

Kuhn is not alone in his confusion. Other students taking Art Theory and Practice studio classes will also have to content with new online learning requirements.

Within the School of Communication, students in their second and third years of study are required to take a two-year acting sequence classes that are expected to be particularly impacted by the transition. The school has yet to announce a detailed contingency plan on their coronavirus website.

Communication junior Saidie Stone is registered to take the final class in that theater sequence. However, she said she doesnt know how students are going to put any of their skills into practice.

Stone explained that her concerns largely depend on whether students are coming back for the second half of the quarter a decision that wont be reassessed by administrators until April 17.

From my perspective as an actor, I can work by myself its not like I wont be able to grow or learn new things but I think the process would be stunted and not as efficient, Stone said.

Previously, Stone had spent Fall and Winter Quarters studying Greek plays and Shakespeare productions, and she said she was supposed to focus on works by Russian playwright Anton Chekhov during the spring.

I think well gain an analytical background but its impossible to get the same thing out if were having the entire quarter online, Stone said.

In order to address the concerns of theater students, the acting faculty have asked students to email their professors stating whether they can access certain technologies or have the space to move around while remote so they can formulate remote learning plans, according to the School of Communication coronavirus website.

Acting faculty will then use this information to create a learning plan, which will be emailed to students before Spring Break ends. However, some School of Communication professors have already started brainstorming ideas to deliver instruction and performance feedback online.

I think the camera work will be very exciting, especially since many of the available acting jobs will be on camera, wrote Theater Prof. Cindy Gold in a news release statement. Id say at least 50 percent of my own auditions in the last year were video submissions, so its terrific that our undergraduates will get early experience with this.

In regards to Checkohv, Gold also described her excitement of seeing intimacy and a focus on subtext closely on camera.

The STEM dilemma

The switch to online classes also poses specific challenges for students in STEM classes with labs as well.

In a Friday email to neuroscience majors, Director of Undergraduate Studies in Neurobiology Valerie Kilman said all spring neuroscience classes will operate online, with the exception of Neuroscience 399, a credit earned through independent research.

Faculty will be working busily over break to adapt their spring courses to online learning platforms, Kilman wrote. Expect to be contacted by your instructor(s) to explain how things will be run.

Still, Weinberg College of Arts and Sciences has yet to send out detailed information to students regarding the format of hands-on classes, despite launching a website dedicated to coronavirus information, and has left individual departments to make announcements.

Similarly, students participating in the final class in the Biology 222 laboratory sequence received notification from their professor Friday morning.

According to the email, students in the laboratory sequence will watch videos of the professor and the lab manager performing the initial steps of the experiments. If students return to campus, they can pick where the lab manager and professor left off, completing the experiments for themselves. The email did not include a contingency plan for the experimental portion of the course if students do not return to campus.

Medill students face in-person reporting restrictions

Specific reporting-based classes in Medill are also working toward overcoming the challenge of not being able to meet in person. Students in Winter Quarter reporting classes have already been impacted by the ban on all in-person reporting put forth by the school ahead of finals week.

This ban is expected to continue into Spring Quarter as classes transition to being conducted online.

In line with other schools, Medill dean Charles Whitaker said in a Tuesday email to The Daily, The faculty who will teach reporting classes in the spring are working as a group to develop a framework for conducting those classes and guidelines for acceptable reporting techniques that do not require face-to-face contact.

Despite these limitations, students will be expected to do reporting, according to the email.

We are in a field where the professionals are doing the same thing, Medill Professor Patti Wolter said. We are dealing with this in class but they are reporting in the world some places going out and putting reporters in hazmat suits; were not doing that.

Wolter explained that Medill had already been discussing digital learning before the University made their universal announcement and continues working on adapting to the situation at hand.

McCormick dean Julio Ottinos Saturday email to The Daily reiterated the theme of considering each class on an individual basis.

No single approach will work across the board, wrote Ottino. We all understand that some courses will provide unique challenges and we are working through those issues now.

Email: cbuchaniec@u.northwestern.eduTwitter: @caty_buchaniec

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Ahead of switch to online classes, the future of hands-on curricula remains unclear - The Daily Northwestern

New Insights to How the Brain Controls the Voice of Bats – Technology Networks

A particular neuronal circuit in the brains of bats controls their vocalisations. This was recently discovered by biologists at Goethe University Frankfurt. Based on the rhythm with which the circuit oscillated, the Frankfurt researchers were able to predict the kind of sounds the bats were about to make. These research results could contribute to a better understanding of human diseases in which language is impaired such as Parkinsons or Tourette syndrome.

Bats are famous for their sonar-based navigation. They use their extremely sensitive hearing for orientation, emitting ultrasound noises and receiving an image of their surroundings based on the echo. Sebas short-tailed bat (Carollia perspicillata), for example, finds the fruits that are its preferred food using this echolocation system. At the same time, bats also use their voices in a somewhat deeper frequency range to communicate with other members of their species. Sebas short-tailed bats employ a vocal range for this purpose that is otherwise only found among songbirds and humans. Like humans, they produce sound through the larynx.

Together with his team, neuroscientist Julio C. Hechavarria from the Institute for Cell Biology and Neuroscience at Goethe University investigated brain activity preceding vocalisation in Sebas short-tailed bats. The scientists were able to identify a group of nerve cells that create a circuitry from the frontal lobe to the corpus striatum in the interior of the brain. When this neural circuit fires off rhythmic signals, the bat emits a vocalisation about half a second later. The type of rhythm seemed to determine whether the bats were about to utter echolocation or communication vocalisations.

Since it is nearly impossible to make a prediction within half a second, the Frankfurt researchers trained a computer to test their hypothesis: The computer analysed the recorded sounds and the neural rhythm separately and attempted to make prognoses using the various rhythms. The result: in its predictions of echolocation versus communication vocalisations, the computer was correct about 80 percent of the time. Predictions were particularly accurate when considering signals from the frontal lobe, an area that in humans has been linked to action planning, among other functions.

The Frankfurt scientists argue that the rhythms they observed in the bat brain are similar to neural rhythms often recorded from the human scalp, and concluded that brain rhythms could be linked to sound production in mammals in general.

Julio Hechavarria: For over 50 years, bats have served as an animal model for studying how the brain processes auditory stimuli and how human language develops. For the first time, we were able to show how distant brain regions in bats communicate with each other during vocalization. At the same time, we know that the corresponding brain networks are impaired in individuals who, for example, stutter as a result of Parkinsons disease or emit involuntary noises due to Tourette syndrome. We therefore hope that by continuing to study vocal behaviour in bats, we can contribute to a better understanding of these human diseases.

Reference:

Kristin Weineck, Francisco Garca-Rosales, Julio C. Hechavarra. Neural oscillations in the fronto-striatal network predict vocal output in bats. PLOS Biology, 2020; 18 (3): e3000658 DOI: 10.1371/journal.pbio.3000658

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New Insights to How the Brain Controls the Voice of Bats - Technology Networks

Gossamer Bio Announces Fourth Quarter and Full-Year 2019 Financial Results and Provides Business Update – BioSpace

SAN DIEGO--(BUSINESS WIRE)-- Gossamer Bio, Inc. (Nasdaq:GOSS), a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, today announced its financial results for the fourth quarter and year ended December 31, 2019 and provided a business update.

Our hearts are with the patients, families, caregivers and medical professionals suffering and sacrificing in the ongoing Covid-19 viral pandemic. We are monitoring the situation on a daily basis to understand the impact on Gossamer and our programs and are taking the necessary actions now to do what is best for our patients, employees and company, said Sheila Gujrathi, M.D., Co-Founder and Chief Executive Officer of Gossamer Bio.

2019 was a year of execution for Gossamer Bio, as we continued to advance all four of our clinical-stage product candidates in our target areas of immunology, inflammation and oncology. Notwithstanding the Covid-19 pandemic, we expect to continue our momentum in 2020, with data from all of our candidates expected this year. We are committed to advancing our product candidates and the field of medicine for the betterment of patients and their families, and we look forward to providing updates on these efforts throughout the year.

Clinical-Stage Product Candidate Updates

GB001: Oral DP2 Antagonist for Eosinophilic Asthma and Chronic Rhinosinusitis (CRS)

GB002: Inhaled PDGFR Inhibitor for Pulmonary Arterial Hypertension (PAH)

GB004: Oral HIF-1 Stabilizer for Inflammatory Bowel Disease

GB1275: Oral CD11b Modulator for Oncology Indications

Financial Results for Quarter and Full Year Ended December 31, 2019

About Gossamer Bio

Gossamer Bio is a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology. Its goal is to be an industry leader in each of these therapeutic areas and to enhance and extend the lives of patients suffering from such diseases.

Forward-Looking Statements

Gossamer cautions you that statements contained in this press release regarding matters that are not historical facts are forward-looking statements. These statements are based on the Companys current beliefs and expectations. Such forward-looking statements include, but are not limited to, statements regarding the anticipated timing of initiation and enrollment of clinical trials for our product candidates; plans to rapidly advance our product candidates; expectations on the timing of data readouts from our clinical studies; the potential clinical benefits of our product candidates; the indications we intend to pursue and our related business strategies; the expected timeframe for funding our operating plan with current cash, cash equivalents and marketable securities; and access to the Companys senior debt facility. The inclusion of forward-looking statements should not be regarded as a representation by Gossamer that any of its plans will be achieved. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in Gossamers business, including, without limitation: potential delays in the commencement, enrollment and completion of clinical trials; disruption to our operations from the recent global outbreak of the Covid-19 pandemic; the Companys dependence on third parties in connection with product manufacturing, research and preclinical and clinical testing; the success of Gossamers clinical trials and preclinical studies for its product candidates; regulatory developments in the United States and foreign countries; unexpected adverse side effects or inadequate efficacy of the Companys product candidates that may limit their development, regulatory approval and/or commercialization, or may result in recalls or product liability claims; Gossamers ability to obtain and maintain intellectual property protection for its product candidates; Gossamers ability to comply with its obligations in collaboration agreements with third parties or the agreements under which it licenses intellectual property rights from third parties; the risk that the funding under the senior debt facility may not be completed on the timeframe Gossamer expects, or at all, including as a result of Gossamer's failure to meet the conditions required for such funding or failure to comply with the affirmative and negative covenants under the credit facility; and other risks described in the Companys prior press releases and the Companys filings with the Securities and Exchange Commission (SEC), including under the heading Risk Factors in the Companys annual report on Form 10-K and any subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and Gossamer undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

GOSSAMER BIO, INC.

CONDENSED CONSOLIDATED FINANCIAL STATEMENT DATA

(UNAUDITED; IN THOUSANDS, EXCEPT SHARE AND PER SHARE DATA)

Three months ended December 31,

Year Ended December 31,

STATEMENTS OF OPERATIONS DATA:

2019

2018

2019

2018

Operating expenses:

Research and development

$

42,596

$

25,872

$

143,403

$

55,283

In process research and development

1,600

-

3,600

49,659

General and administrative

11,591

13,935

39,136

44,051

Total operating expenses

55,787

39,807

186,139

148,993

Loss from operations

(55,787

)

(39,807

)

(186,139

)

(148,993

)

Other income, net

1,089

1,013

5,832

2,024

Net loss

$

(54,698

)

$

(38,794

)

$

(180,307

)

$

(146,969

)

Net loss per share, basic and diluted

$

(0.89

)

$

(4.92

)

$

(3.29

)

$

(22.59

)

Weighted average common shares outstanding, basic and diluted

61,282,084

7,878,824

54,740,170

6,504,871

December 31,

BALANCE SHEET DATA:

2019

2018

Cash, cash equivalents, and marketable securities

$

401,829

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Gossamer Bio Announces Fourth Quarter and Full-Year 2019 Financial Results and Provides Business Update - BioSpace