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Researchers Investigate How COVID-19 Impacts the Brain – UANews

The coronavirus is well known for attacking the lungs and causing coughing fits, difficulty breathing, fever and even deadly pneumonia. But what does it do to the brain?

A University of Arizona-led study aims to find out.

Lee Ryan, professor and head of the Department of Psychology in the College of Science, is the study's principal investigator.

Earlier coronaviruses, Ryan said, have been shown to make their way from the lungs and nose where the viruses live and breed and into the brain through nerves that connect to the brainstem or directly to the brain.

But scientists are "still guessing" at whether the new coronavirus has the same effects, she said. Some COVID-19 patients have shown neurological symptoms such as nausea, vomiting, headache and a loss of taste and smell. The Centers for Disease Control and Prevention recently added the latter two to its list of symptoms of the coronavirus.

"This is kind of, in a way, an opportunity for us to actually follow people from the time we know they've had exposure to the coronavirus and follow them to see how they do cognitively," said Ryan, who studies the aging brain and risk factors for Alzheimer's disease and other types of dementia.

The study involves finding 2,000 people who have had COVID-19 or have recently shown symptoms of the virus. Luckily, Ryan and her team already have a mechanism to do this a pool of about 50,000 people participating in an existing research project.

In 2014, Ryan and Matthew Huentelman, a research associate professor at the College of Medicine Phoenix and a professor in the neurogenomics division of the Translational Genomics Research Institute, launched the MindCrowd research project in an effort to better understand the risk factors for Alzheimer's disease.

About 140,000 people have participated in an online memory test on the MindCrowd website. Of those, roughly 50,000 have completed a battery of cognitive tests related to memory and processing speed and have agreed to remain in contact with the researchers for additional studies.

Those 50,000 participants will now receive surveys asking whether they've had COVID-19 symptoms over the past several months, been diagnosed with the virus or tested negative for it. Researchers expect to send the surveys sometime this month, Ryan said.

"That was part of the idea behind MindCrowd, was that not only would we get the one-time testing, but we would really make a relationship with a really large group of people who we could go back to and ask new questions of," she said.

The 2,000 participants with the highest likelihood of having had the virus will be asked to complete cognitive tests that check aspects of their memory, executive functions, processing speed and more. They will also receive a test kit to obtain a blood sample from a finger prick, which will then be mailed back to the researchers. That collection process, scientists hope, could be completed in four to six months.

Once the blood samples have been sent back to the researchers, scientists with the Translational Genomics Research Institute, or TGen, will test them for antibodies at the company's lab at Northern Arizona University. The presence of antibodies in blood samples will tell researchers who has been exposed to the coronavirus.

Researchers expect that of the 2,000 participants, about 500 will test positive for previous exposure to the coronavirus. The others will serve as controls, or subjects to which they can make comparisons.

The UArizona Center for Innovation in Brain Science is funding the project with a $60,000 grant.

"Drs. Ryan and Huentelman's innovative MindCrowd platform is perfectly positioned for rapid global deployment to investigate the impact of COVID-19 on brain function and risk of Alzheimer's disease. The Center for Innovation in Brain Science is proud to support this critical endeavor," said Roberta Diaz Brinton, the center's director.

Though MindCrowd came about long before the age of physical distancing, it's conveniently compatible with today's circumstances.

"The great thing about doing this in MindCrowd is that we can do this right now without doing any face-to-face," Ryan said. "We've done this for other studies, and so we know that people will participate in these things by mail."

In addition to Ryan and Huentelman, the study also involves researchers Meredith Hay, a professor of physiology and member of the university's BIO5 Institute and John Altin, an assistant professor in TGen's pathogen and microbiome division.

"This is really fundamental research that will apply precision medicine to our understanding of cognitive aging," Hay said. "With enough data from the participants involved in the MindCrowd study, now also including COVID-19 diagnoses, we hope to be able to create individualized tools that can intervene where needed and preserve high cognitive function across the lifespan."

The researchers hope to be able to provide the test results to participants, and TGen is working through a certification process to be able to do that, Ryan said.

The study, researchers hope, would be the start of a more comprehensive investigation of the effects of coronavirus on the brain, which requires following subjects over several years to study changes as they age, Ryan said. There's growing federal interest in that type of work, she added.

"This would be an amazing cohort that would be well-characterized, would have baseline testing and that we could put in that pipeline to start following over a longer timeframe," Ryan said.

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Researchers Investigate How COVID-19 Impacts the Brain - UANews

Automatic Biochemistry Analyzers Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 – Cole of Duty

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Automatic Biochemistry Analyzers Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 - Cole of Duty

Team of Biochemists and Virologists Discover Potential Targets for COVID-19 Therapy – SciTechDaily

A team of biochemists and virologists at Goethe University and the Frankfurt University Hospital were able to observe how human cells change upon infection with SARS-CoV-2, the virus causing COVID-19 in people. The scientists tested a series of compounds in laboratory models and found some which slowed down or stopped virus reproduction. These results now enable the search for an active substance to be narrowed down to a small number of already approved drugs.

Based on these findings, a US company reports that it is preparing clinical trials. A Canadian company is also starting a clinical study with a different substance.

Professor Jindrich Cintal. Credit: University Hospital Frankfurt

Since the start of February, the Medical Virology of the Frankfurt University Hospital has been in possession of a SARS-CoV-2 infection cell culture system. The Frankfurt scientists in Professor Sandra Cieseks team succeeded in cultivating the virus in colon cells from swabs taken from two infected individuals returning from Wuhan (Hoehlet al.NEJM2020).

Using a technique developed at the Institute for Biochemistry II at Goethe University Frankfurt, researchers from both institutions were together able to show how a SARS-CoV-2 infection changes the human host cells. The scientists used a particular form of mass spectrometry called the mePROD method, which they had developed only a few months previously. This method makes it possible to determine the amount and synthesis rate of thousands of proteins within a cell.

The findings paint a picture of the progression of a SARS-CoV-2 infection: whilst many viruses shut down the hosts protein production to the benefit of viral proteins, SARS-CoV-2 only slightly influences the protein production of the host cell, with the viral proteins appearing to be produced in competition to host cell proteins. Instead, a SARS-CoV-2 infection leads to an increased protein synthesis machinery in the cell. The researchers suspected this was a weak spot of the virus and were indeed able to significantly reduce virus reproduction using something known as translation inhibitors, which shut down protein production.

Twenty-four hours after infection, the virus causes distinct changes to the composition of the host proteome: while cholesterol metabolism is reduced, activities in carbohydrate metabolism and in modification of RNA as protein precursors increase. In line with this, the scientists were successful in stopping virus reproduction in cultivated cells by applying inhibitors of these processes. Similar success was achieved by using a substance that inhibits the production of building blocks for the viral genome.

Dr. Christian Mnch. Credit: Uwe Dettmer, Goethe University Frankfurt

The findings have already created a stir on the other side of the Atlantic: in keeping with common practice since the beginning of the corona crisis, the Frankfurt researchers made these findings immediately available on a preprint server and on the website of the Institute for Biochemistry II. Professor Ivan Dikic, Director of the Institute, comments: Both the culture of open science, in which we share our scientific findings as quickly as possible, and the interdisciplinary collaboration between biochemists and virologists contributed to this success. This project started not even three months ago, and has already revealed new therapeutic approaches to COVID-19.

Professor Sandra Ciesek, Director of the Institute for Medical Virology at the University Hospital Frankfurt, explains: In a unique situation like this we also have to take new paths in research. An already existing cooperation between the Cinatl and Mnch laboratories made it possible to quickly focus the research on SARS-CoV-2. The findings so far are a wonderful affirmation of this approach of cross-disciplinary collaborations.

Among the substances that stopped viral reproduction in the cell culture system was 2-Deoxy-D-Glucose (2-DG), which interferes directly with the carbohydrate metabolism necessary for viral reproduction. The US company Moleculin Biotech possesses a substance called WP1122, a prodrug similar to 2-DG. Recently, Moleculin Biotech announced that they are preparing a clinical trial with this substance based on theresults from Frankfurt.

Based on another one of the substances tested in Frankfurt, Ribavirin, the Canadian company Bausch Health Americas is starting a clinical study with 50 participants.

Dr. Christian Mnch, Head of the Protein Quality Control Group at the Institute for Biochemistry II and lead author, comments: Thanks to the mePROD-technology we developed, we were for the first time able to trace the cellular changes upon infection over time and with high detail in our laboratory. We were obviously aware of the potential scope of our findings. However, they are based on a cell culture system and require further testing. The fact that our findings may now immediately trigger further in vivo studies with the purpose of drug development is definitely a great stroke of luck. Beyond this, there are also other potentially interesting candidates among the inhibitors tested, says Mnch, some of which have already been approved for other indications.

Professor Jindrich Cinatl from the Institute of Medical Virology and lead author explains: The successful use of substances that are components of already approved drugs to combat SARS-CoV-2 is a great opportunity in the fight against the virus. These substances are already well characterised, and we know how they are tolerated by patients. This is why there is currently a global search for these types of substances. In the race against time, our work can now make an important contribution as to which directions promise the fastest success.

Reference: SARS-CoV-2 infected host cell proteomics reveal potential therapy targets by Denisa Bojkova, Kevin Klann, Benjamin Koch, Marek Widera, David Krause, Sandra Ciesek, Jindrich Cinatl, Christian Mnch, 14 May 2020, Nature.DOI: 10.1038/s41586-020-2332-7

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Team of Biochemists and Virologists Discover Potential Targets for COVID-19 Therapy - SciTechDaily

Greg Phillips and Heeyoung Tai receive Excellence in Advising Award – The Miami Student

By Kristal Humphrey, university news and communications

Excellence in Academic Advising awards were presented to Greg Phillips in music and Heeyoung Tai in chemistry and biochemistry. Both are chief departmental advisers.

The award recognizes faculty and staff members who spend a significant portion of their time providing exemplary academic advising services to undergraduate students and have exhibited exceptional leadership in advancing academic advising at Miami. Nominees must also provide outstanding support for and accessibility to students.

Phillips, associate professor of music, has been at Miami for nearly 30 years and has been a chief departmental adviser for more than 10 years.

His nominators say Phillips, who is affectionately known as GP, is widely praised by students and faculty alike and both turn to him for guidance.

One nominator said if people had the opportunity to ask any student in music about GP, they would learn that he is not only respected and valued, but beloved. This is because they know he is there for them, and that he will do whatever is necessary to ensure their success.

Mentioning the complexity of the music department curriculum, one nominator says, Greg helps to shepherd students through this maze of requirements with a steady hand and generous heart. Im not sure a single student graduates with a degree in music without having engaged with Greg on at least one occasion.

In addition to being the chief departmental adviser for chemistry and biochemistry, Tai is also a senior lecturer, faculty adviser for the pre-med academic scholars program, faculty adviser to the Korean Student Association, and faculty associate for the Mallory-Wilson Center for Healthcare Education.

She was recognized for her work as an individual adviser through the Mallory-Wilson Center when she received its Pre-Health Education Center Faculty Recognition Award in 2015.

Nominators praise Tai for her commitment to students and not only mentoring majors in her own department, but also pre-medical studies co-majors from other departments.

In appointments with Tai, a student not only learns about academic rules and requirements but also learns to use critical thinking skills to break goals down into achievable tasks, one nominator said.

Commenting on Tais ability to establish rapport with students, a nominator said, Many students continue to share their accomplishments with Heeyoung long after graduation because they know she will celebrate their successes as she did when she was their academic adviser on campus.

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Greg Phillips and Heeyoung Tai receive Excellence in Advising Award - The Miami Student

What is the ACE2 receptor, how is it connected to coronavirus and why might it be key to treating COVID-19? The experts explain – Midland Daily News

(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)

Krishna Sriram, University of California San Diego; Paul Insel, University of California San Diego, and Rohit Loomba, University of California San Diego

(THE CONVERSATION) In the search for treatments for COVID-19, many researchers are focusing their attention on a specific protein that allows the virus to infect human cells. Called the angiotensin-converting enzyme 2, or ACE2 receptor, the protein provides the entry point for the coronavirus to hook into and infect a wide range of human cells. Might this be central in how to treat this disease?

We are scientists with expertise in pharmacology, molecular biology and biochemistry, with a strong commitment to applying these skills to the discovery of novel therapies for human disease. In particular, all three authors have experience studying angiotensin signaling in various disease settings, a biochemical pathway that appears to be central in COVID-19. Here are some of the key issues to understand about why theres so much focus on this protein.

What is the ACE2 receptor?

ACE2 is a protein on the surface of many cell types. It is an enzyme that generates small proteins by cutting up the larger protein angiotensinogen that then go on to regulate functions in the cell.

Using the spike-like protein on its surface, the SARS-CoV-2 virus binds to ACE2 like a key being inserted into a lock prior to entry and infection of cells. Hence, ACE2 acts as a cellular doorway a receptor for the virus that causes COVID-19.

Where in the body is it found?

ACE2 is present in many cell types and tissues including the lungs, heart, blood vessels, kidneys, liver and gastrointestinal tract. It is present in epithelial cells, which line certain tissues and create protective barriers.

The exchange of oxygen and carbon dioxide between the lungs and blood vessels occurs across this epithelial lining in the lung. ACE2 is present in epithelium in the nose, mouth and lungs. In the lungs, ACE2 is highly abundant on type 2 pneumocytes, an important cell type present in chambers within the lung called alveoli, where oxygen is absorbed and waste carbon dioxide is released.

What is the normal role ACE2 plays in the body?

ACE2 is a vital element in a biochemical pathway that is critical to regulating processes such as blood pressure, wound healing and inflammation, called the renin-angiotensin-aldosterone system (RAAS) pathway.

ACE2 helps modulate the many activities of a protein called angiotensin II (ANG II) that increases blood pressure and inflammation, increasing damage to blood vessel linings and various types of tissue injury. ACE2 converts ANG II to other molecules that counteract the effects of ANG II.

Of greatest relevance to COVID-19, ANG II can increase inflammation and the death of cells in the alveoli which are critical for bringing oxygen into the body; these harmful effects of ANG II are reduced by ACE2.

When the SARS-CoV-2 virus binds to ACE2, it prevents ACE2 from performing its normal function to regulate ANG II signaling. Thus, ACE2 action is inhibited, removing the brakes from ANG II signaling and making more ANG II available to injure tissues. This decreased braking likely contributes to injury, especially to the lungs and heart, in COVID-19 patients.

Does everyone have the same number of ACE2 on their cells?

No. ACE2 is present in all people but the quantity can vary among individuals and in different tissues and cells. Some evidence suggests that ACE2 may be higher in patients with hypertension, diabetes and coronary heart disease. Studies have found that a lack of ACE2 (in mice) is associated with severe tissue injury in the heart, lungs and other tissue types.

Does the quantity of receptors determine whether someone gets more or less sick?

This is unclear. The SARS-CoV-2 virus requires ACE2 to infect cells but the precise relationship between ACE2 levels, viral infectivity and severity of infection are not well understood.

Even so, aside from its ability to bind the SARS-CoV-2 virus, ACE2 has protective effects against tissue injury, by mitigating the pathological effects of ANG II.

When the amount of ACE2 is reduced because the virus is occupying the receptor, individuals may be more susceptible to severe illness from COVID-19. That is because enough ACE2 is available to facilitate viral entry but the decrease in available ACE2 contributes to more ANG II-mediated injury. In particular, reducing ACE2 will increase susceptibility to inflammation, cell death and organ failure, especially in the heart and the lung.

Which organs are most severely damaged by SARS-CoV-2?

The lungs are the primary site of injury by SARS-CoV-2 infection, which causes COVID-19. The virus reaches the lungs after entry in the nose or mouth.

ANG II drives lung injury. If there is a decrease in ACE2 activity (because the virus is binding to it), then ACE2 cant break down the ANG II protein, which means there is more of it to cause inflammation and damage in the body.

The virus also impacts other tissues that express ACE2, including the heart, where damage and inflammation (myocarditis) can occur. The kidneys, liver and digestive tract can also be injured. Blood vessels may also be a site for damage.

In a recent research paper, we argued that a key factor that determines severity of damage in patients with COVID-19 is abnormally high ANG II activity.

What are ACE inhibitors? Are they a possible treatment or prophylactic for SARS-CoV-2?

Angiotensin converting enzyme (ACE, aka ACE1) is another protein, also found in tissues such as the lung and heart, where ACE2 is present. Drugs that inhibit the actions of ACE1 are called ACE inhibitors. Examples of these drugs are ramipril, lisinopril, and enalapril. These drugs block the actions of ACE1 but not ACE2. ACE1 drives the production of ANG II. In effect, ACE1 and ACE2 have a yin-yang relationship; ACE1 increases the amount of ANG II, whereas ACE2 reduces ANG II.

By inhibiting ACE1, ACE inhibitors reduce the levels of ANG II and its ability to increase blood pressure and tissue injury. ACE inhibitors are commonly prescribed for patients with hypertension, heart failure and kidney disease.

Another commonly prescribed class of drugs, angiotensin receptor blockers (ARBs, e.g., losartan, valsartan, etc.) have similar effects to ACE inhibitors and may also be useful in treating COVID-19.

Evidence for a protective effect of ACE inhibitors and angiotensin receptor blockers in patients with COVID-19 was shown in recent work co-authored by one of us - Dr. Loomba.

No evidence exists to suggest prophylactic use of these drugs; we do not advise readers to take these drugs in the hopes that they will prevent COVID-19. We wish to emphasize that patients should only take these drugs as instructed by their health care provider.

New clinical trial tests ACE inhibitor against SARS-CoV-2

In collaboration with a multidisciplinary group of investigators, Dr. Loomba has initiated a multicenter (randomized, double-blinded, placebo-controlled) clinical trial to examine the efficacy of ramipril - an ACE inhibitor - compared to a placebo in reducing mortality, ICU admission or need for mechanical ventilation in patients with COVID-19.

[Get facts about coronavirus and the latest research. Sign up for The Conversations newsletter.]

This article is republished from The Conversation under a Creative Commons license. Read the original article here: https://theconversation.com/what-is-the-ace2-receptor-how-is-it-connected-to-coronavirus-and-why-might-it-be-key-to-treating-covid-19-the-experts-explain-136928.

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What is the ACE2 receptor, how is it connected to coronavirus and why might it be key to treating COVID-19? The experts explain - Midland Daily News

Evensen, Kasl named winners of campus Herfurth-Kubly Awards – University of Wisconsin-Madison

UWMadison graduating seniors Claire Evensen and Patrick Kasl have been named 2020 winners of Herfurth-Kubly Awards for Comprehensive Undergraduate Excellence, among the oldest and most prestigious honors on campus.

The awards of $2,000 each are given annually to seniors who have made the most effective use of their time at UWMadison.

Claire Evenson

A committee comprised of faculty and staff, a former award recipient, and a representative of the donors family selects recipients based on high academic achievement, effective communication skills, leadership in significant extra-curricular activities, financial self-support and personal initiative.

This year, 311 students were nominated by faculty and staff. The committee selected thirteen finalists and made two awards, with two honorable mentions.

The award is made possible through the generosity of Theodore Herfurth, a member of the class of 1894, and his daughter, Theodora (Teddy) Kubly.

Evensen, of Verona, Wisconsin, is the winner of the 2020 Teddy Kubly Award for Comprehensive Undergraduate Excellence. She earned a bachelors degree this month in biochemistry and mathematics, with comprehensive honors in biochemistry and the liberal arts.

Evensens research on the mechanisms of prokaryotic transcription initiation led to a Goldwater Scholarship and an Astronaut Scholarship. She served as president of UWMadisons chapter of the American Society for Biochemistry and Molecular Biology, and was an active member of the clarinet studio and university wind ensemble.

Evensen was a finalist this academic year for a Rhodes Scholarship and received the Marshall Scholarship. At the University of Oxford, she will pursue a masters degree in mathematical modelling and scientific computing.

Patrick Kasl

Kasl, of Wyoming, Minnesota, is the winner of the 2020 Theodore Herfurth Award for Comprehensive Undergraduate Excellence. He earned a bachelors degree this month in biomedical engineering. He has spent time researching in three labs at UWMadison. His projects have been diverse, although a unifying theme has been the development of cellularly inspired therapeutics. He was an offensive lineman for the football team on a full-ride scholarship for two years and a peer mentor through the Engineering Department. This fall, he will be attending the University of California-San Diego to pursue a Ph.D. in bioengineering.

Honorable mentions this year went to Christopher Gitter (pharmacology and toxicology, with certificates in environmental studies and global health) and Joseph Kern (materials science and engineering and computer science). Each received a $500 award.

The following students were finalists: Shiloah Coley (journalism, with certificates in studio art and African American studies); Kevin Crosby (nutritional sciences, with a certificate in environmental studies); Kenneth Fiala (biochemistry); Kristina Geiger (biomedical engineering, with certificates in business and biology in engineering); Michael Gui (microbiology and neurobiology); Helen Heo (molecular biology and neurobiology, with a certificate in stem cell sciences); Maura McDonagh (biomedical engineering and communication arts); Anusha Naik (molecular biology, anthropology, and African studies); and Luquant Singh (applied math, engineering, and physics).

A member of the Herfurth family has been involved with the awards since the establishment of the Theodore Herfurth Award in 1928. (The Teddy Herfurth Kubly Award followed in 1943.) Beth Kubly, granddaughter of Theodore Herfurth and daughter of Teddy Herfurth Kubly, currently serves on the selection committee.

My mother used to tell me how her father would return home from the award dinner enthusiastic, impressed, and pleased, says Beth Kubly. For him to witness the levels to which students could rise was both inspiring and invigorating. Some winnersbecame life-long friends. As my parents becameincreasingly involved they were equally impressed by the remarkable finalists. And now I, the third generation of the family to be engaged with these awards, remain likewise amazed by your accomplishments.

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Evensen, Kasl named winners of campus Herfurth-Kubly Awards - University of Wisconsin-Madison

It’s Just Not the Same, Part 3 Southwestern University – Southern Newsroom

Read part 1 and part 2.

As they prepared faculty for the transition to remote learning, one reassuring message Julie Sievers, director of the Center for Teaching, Learning, and Scholarship, and Melanie Hoag, instructional technologist, wanted to convey to professors was that this isnt really a time for innovation, as Sievers says. Most faculty and students were already susceptible to stress and anxiety having to learn and get comfortable with new online toolsthink, for instance, of how many of us have fumbled with just making sure microphones were turned on during a Google or Zoom meeting. Melanie and I have been urging people to adopt the simplest tools and strategies possible to reduce the cognitive load both for themselves and for their students, Sievers remarks.

Hoag agrees. But, she adds, they have both observed innovation and creativity [in] what the faculty have done and are continuing to do to provide the best experiences for their students. The faculty have also demonstrated their signature commitment to helping students connect across disciplines, beyond the classroom, and to the local and global community.

In her Advanced Biochemistry Lab, for example, Maha Zewail-Footes students were in the midst of an independent project and could not complete their research in the lab once stay-at-home orders went into effect. So, she explains, I created assignments that still taught the students how to design experiments, troubleshoot, and summarize data, but I also wanted students to use this opportunity to make a difference during this difficult time.

For one such project, students were given the freedom to come up with a project that would help others, such as tutoring students who were now being homeschooled or producing videos to teach children science while they are at home, including the myths and truths about the novel coronavirus. In her Biochemistry of Nucleic Acids, meanwhile, the students switched gears by learning about the biochemistry of SARS-CoV-2 (the virus) and COVID-19 (the disease), compiling as many questions as they could conjure: How is it transmitted? How does it recognize a receptor? How does the virus replicate? What biochemical tests, vaccines, and therapeutics might there be for the disease? The students researched answers in the current scholarship, just as they would when conducting a literature review for any scientific question, and shared their discoveries with one another.

As it has been for faculty teaching science labs, making the shift to online learning poses particular challenges to those teaching studio art. Ron Geibel, a creative in that hes an assistant professor of art who specializes in ceramics and design, had to get even more creative with how he was facilitating his studio courses given the issue of access to materials for drawing, painting, and sculpturealthough the same would apply, he adds, even if I was teaching a design course. His more advanced students are familiar with how to set up a safe work environment, and a few of his seniors were able to take clays home with them and continue to work, but younger students might not be as versed in, for example, how to properly ventilate their spaces to avoid the noxious fumes wafting from the solvents used to dilute oil paint or clean brushes. And even advanced students might not have the resources to create safe home studios, nor did Geibel want to put extra pressure on any of his students by asking them to continue making at home with so many limitations.

Still, he says, they could still be learning about form and color, even though the main componentthe materialis missing. So his beginning Ceramics: Hand-Forming class is posting asynchronous responses to excerpts of documentaries that hes curated about how different cultures across the world and throughout history have approached and appreciated ceramics. His senior seminar, meanwhile, is meeting weekly to discuss assigned readings on materiality and crafts theory as well as videos produced by the Ceramic Materials Workshop that introduce viewers to the properties and engineering of clays and glazes. Both groups have been invited to join Geibel in sharing relevant images of artwork on Instagram group chatsbecause, he explains, its a platform that has changed art significantly in the past 10 years, but also because its a good way for me to see what theyre looking at, and I wanted to use social media in a way that theyre already doing so it doesnt feel like extra work.

In addition, Geibels seniors are researching and writing proposals for art projects and exhibitions that they unfortunately will not get to makeat least not until they again have access to studios, even if that means sometime after graduation. Nevertheless, articulating the objectives, plans, and significance of their visions and designs is an important skill for artists to practice considering that proposals are crucial in applying for funding or for exhibition space. So although his students arent necessarily creating in the sense of making art, they are engaging in significant creative projects as well as really great conversations and even heated debates about the creative arts.

Associate Professor of History Jess Hower had to reimagine an assignment in her History of the British Isles since 1688 course that she looks forward to every time the seminar is offered: an in-class debate, worth 10% of each students final grade, in which her students recreate parliamentary arguments made in spring 1886 for and against the First Home Rule Bill, a proposed law granting Ireland self-autonomy and independence from the United Kingdom. Students are assigned to one team or the other, prepare by reading numerous primary and secondary sources on each side of the debate, and then spend a class period engaged in fierce formal debate before closing with a postmortem in which they discuss which side they truly thought had the strongest argument.

Hower says that the event is so energetic and is such an exciting moment, and its also a crucial piece of students understanding of the history of Irelands role in the British Islesits an opportunity for students to embody and empathize with history, she explains. She also couldnt bear to disappoint the students who enrolled in the seminar partly because of this particular assignment. So when Southwestern converted to distance learning, she knew she couldnt replicate the debate environment, but she also couldnt just omit the experience entirely. She asked her students to prepare as they normally would, but instead of an in-class dialogue, the students would engage in an asynchronous debate in Google Docs, asserting and rebutting claims during a 48-hour period. All 25 students participated, eventually creating a 32-page single-spaced document. It was sophisticated, it was scholarly, and they were engaging with the material. It was awesome! she recalls proudly. That was also the Monday we started virtual teaching, so I thought, Maybe we can get through this.

It was sophisticated, it was scholarly, and they were engaging with the material. It was awesome!

Although current students at Southwestern are part of the multigenerational group known as digital natives, not all have found the transition to remote learning easy. Its not that students struggle so much with navigating videoconferences or Moodlemany, after all, are more comfortable with the technology than their professors are. Rather, for many SU students, getting and maintaining access to high-quality Internet service has been a strugglea concern one might expect from those living in rural areas but has nevertheless been echoed by those living in urban and suburban neighborhoods, where many household members at a time might be competing for bandwidth and large populations of people working from home are experiencing areawide outages thanks to overwhelmed service providers.

Some of them are struggling with access to technology, Associate Professor of Psychology Erin Crockett 05 shares. One of her students, for instance, has a dial-up connection, so whenever Zoom freezes up during a class session, the student has to call in. Others are working on computers that are not equipped with cameras, so they, too, have been calling into classes and using their smartphones to share their screens.

But one of the most difficult obstacles that their students are having to overcome are the rollercoaster of emotions this semester has elicited: the shock of having to suddenly move out of the residence halls; the sadness of not having more frequent interaction with friends; the stress of losing on- or off-campus jobs or knowing that loved ones have been furloughed or laid off; the annoyance or frustration of readjusting to living with ones family after months or years of independence at college (or else the strain of enduring toxic family environments or unstable living arrangements); the frustration of trying to homeschool or help homeschool children or younger siblings; the boredom of not having internships, jobs, athletics, or other cocurricular activities to fill their evenings and weekends; and the fear of the unknown in the face of a worldwide public-health crisis that is anxiety provoking enough in the abstract but downright traumatic when a loved one has been infected with the virus, is on a ventilator in an ICU, or has lost their life to COVID-19.

Many students, however, have adapted as well as they canwith successand their professors are grateful. To be honest, none of this would have been remotely possible without these two particular groups, Hower says of the students in her History of the British Isles and Witches, Nuns, Prostitutes, Wives, and Queens seminars. Its like I hand-picked the perfect combination of students who could not only face the challenges that were dealing with but also embrace them and commit to doing their best. If they werent gameif they werent willing or responsive to methen Id be lost. My groups are amazing, and that has been the key to all of it.

Crockett describes her students as doing brilliantly, and shes proud of what theyre accomplishing in the midst of such challenging circumstances. Nobody wanted this, no one asked for this, [and] most of us didnt even expect this, so getting to a place where we can say, But given this is what it is, how can we move forward? has been a productive conversation to have with them. She adds that for especially SU seniors, shes collaborating with colleagues to brainstorm some sort of online celebration that will provide the closure they need and deserve. Its important to have that time to say goodbye and mark an ending to something that was really meaningful for them, she says.

Zewail-Foote sees her students resilience as evidence of a Southwestern education. Change can be difficult, but learning how to adapt will be a lesson we all take away from this situation, she argues. This is a scary time, but this is also a learning moment on so many levels. A liberal-arts education is not just about learning course content. Now, more than ever, is the time to learn how to handle difficult situations, how to grow as individuals, and how to move forward.

In the concluding installment of this series, SU professors will reflect on the highs and lows of remote teaching this spring as well as the potential impacts of this experience on their face-to-face courses later this fall.

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It's Just Not the Same, Part 3 Southwestern University - Southern Newsroom

COVID19 Impact: Global Veterinary biochemistry analyzers Market Trend, Strengths, Threats, Research Report and Forecast (2020 To 2027) – Azizsalon…

The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report.

A new informative research report on the global Veterinary biochemistry analyzers market has been recently added by Million Dollar Research to its database. It covers different business parameters such as global market trends, market shares, market size, drivers, restraints and various geographies across the world. The primary and secondary research methodologies have been used to analyze the global market research terminologies.

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The Top Key Players include: Abaxis Europe, AMS Alliance, Biochemical Systems International, BPC BioSed, Carolina Liquid Chemistries, Crony Instruments, DiaSys Diagnostic Systems, Eurolyser Diagnostica, Gesan Production, Heska, I.

The study presents detailed market analysis with inputs derived from industry professionals across the value chain. A special focus has been made on key countries such as U.S., Canada, Mexico, U.K., Germany, Spain, France, Italy, China, Brazil, Saudi Arabia and South Africa. The market data is gathered from extensive primary interviews and secondary research. The market size is calculated based on the revenue generated through sales from all the given segments and sub-segments in the research scope. The market sizing analysis includes both top-down and bottom-up approaches for data validation and accuracy measures. The report provides data tables, includes charts and graphs for visual analysis.

The study assesses factors such as segmentation, description, and applications of Veterinary biochemistry analyzers industries. It derives accurate insights to give a holistic view of the dynamic features of the business, including shares, profit generation, thereby directing focus on the critical aspects of the business. Moreover, it explains the most important aspects of the businesses which help to drive the business flow successfully. An exploration of drivers helps out to clarify the businesss growing factor over the forecast period.

Global Veterinary biochemistry analyzers Market Key Segments:

For product type segment, this report listed main product type of Veterinary Biochemistry Analyzers market in global. Automatic Semi-automatic

For end use/application segment, this report focuses on the status and outlook for key applications. End users are also listed. Pet Hospital Veterinary Station Other

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This industry report analyses the market estimates and forecasts of all the given segments on a global as well as regional levels. The study provides historical market data for 2015, 2016 revenue estimations are presented for 2017 and forecasts from 2018 to 2027. The study focuses on market trends, leading players, supply chain trends, technological innovations, key developments, and future strategies. With comprehensive market assessment across the major geographies such as North America, Europe, Asia Pacific, Middle East, Latin America and Rest of the world the report is a valuable asset for the existing players, new entrants and the future investors.

Following questions are addressed through this global research report:

Table of Content (TOC)

Global Veterinary biochemistry analyzers Market Research Report

Chapter 1 Global Veterinary biochemistry analyzers Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export

Chapter 6 Production, Revenue (Value), Price Trend by Type

Chapter 7 Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Market Forecast

For More Information: http://www.milliondollarresearch.com/global-veterinary-biochemistry-analyzers-market/8736/

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COVID19 Impact: Global Veterinary biochemistry analyzers Market Trend, Strengths, Threats, Research Report and Forecast (2020 To 2027) - Azizsalon...

Outlook into the Worldwide Companion Animal Diagnostics Industry to 2027 – Demand for Advanced Technologies to Improve Disease Diagnosis -…

Dublin, May 14, 2020 (GLOBE NEWSWIRE) -- The "Companion Animal Diagnostics Market Forecast to 2027 - COVID-19 Impact and Global Analysis by Technology; Application; Animal Type; End User;and Geography" report has been added to ResearchAndMarkets.com's offering.

The companion animal diagnostics market was valued at US$ 2,031.62 Mn in 2019 and is projected to reach US$ 2,684.86 Mn by 2027; it is expected to grow at a CAGR of 4.1% from 2020 to 2027.

The growing prevalence of chronic diseases in pet animals and the increasing adoption of pets for companionship are the major factors driving the growth of the companion animal diagnostics market. However, increasing pet care costs and extended pet lifespan are expected to restrain the growth of the market during the forecast period.

The companion animal diagnostics market offerings deal with the epidemiology and pathogenesis of domestic animals and facilitate the prevention of further complications with the health of pets and their owners.

The global companion animal diagnostics market is segmented into technology, animal type, application, and end-user. Based on technology, the companion animal diagnostics market is further segmented into immunodiagnostics, clinical biochemistry, hematology, urinalysis, molecular diagnostics, and others. The immunodiagnostics segment held the largest share of the market in 2019. However, the clinical biochemistry segment is anticipated to register a higher CAGR in the market during the forecast period.

A few essential primary and secondary sources included in the report areAnimal & Plant Health Agency, American Veterinary Medical Association, and the Canadian Centre for Veterinary Biologics.

Reasons to Buy

Key Topics Covered:

1. Introduction

2. Companion Animal Diagnostic Market - Key Takeaways

3. Research Methodology3.1 Coverage3.2 Secondary Research3.3 Primary Research

4. Global Companion Animal Diagnostics Market- Market Landscape4.1 Overview4.2 PEST Analysis4.2.1 North America4.2.2 Europe4.2.3 Asia Pacific4.2.4 Middle East & Africa4.2.5 South & Central America4.3 Expert Opinion

5. Global Companion Animal Diagnostics Market- Key Market Dynamics5.1 Key Drivers5.1.1 Growing Prevalence of Chronic Diseases in Pet Animals5.1.2 Increasing Adoption of Pets for Companionship5.2 Key Restraints5.2.1 Increasing Pet Care Costs and Extended Pet Lifespan5.3 Opportunities5.3.1 Demand for Advanced Technologies to Improve Disease Diagnosis5.4 Trends5.4.1 Escalating Number of Product Launches5.5 Impact Analysis

6. Companion Animal Diagnostics Market- Global Analysis6.1 Global Companion Animal Diagnostics Market Revenue Forecast And Analysis6.2 Global Companion Animal Diagnostics Market, By Geography - Forecast And Analysis6.3 Market Positioning of Key Players

7. Companion Animal Diagnostics Market Analysis - By Technology7.1 Overview7.2 Companion Animal Diagnostics Market Share, by Technology, 2019 and 2027 (%)7.3 Immunodiagnostics7.3.1 Overview7.3.2 Immunodiagnostics: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.3.3 Lateral Flow Assays7.3.3.1 Overview7.3.3.2 Lateral Flow Assays: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.3.4 ELISA Tests7.3.4.1 Overview7.3.4.2 ELISA Tests: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.3.5 Allergen-Specific Immunodiagnostic Tests7.3.5.1 Overview7.3.5.2 Allergen-Specific Immunodiagnostic Tests: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.3.6 Immunoassay Analyzers7.3.6.1 Overview7.3.6.2 Immunoassay Analyzers: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.4 Clinical Biochemistry7.4.1 Overview7.4.2 Clinical Biochemistry: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.4.3 Clinical Chemistry Analysis7.4.3.1 Overview7.4.3.2 Clinical Chemistry Analysis: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.4.4 Glucose Monitoring7.4.4.1 Overview7.4.4.2 Glucose Monitoring: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.4.5 Blood Gas Electrolyte Analysis7.4.5.1 Overview7.4.5.2 Blood Gas Electrolyte Analysis: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.5 Hematology7.5.1 Overview7.5.2 Hematology: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.6 Urinalysis7.6.1 Overview7.6.2 Urinalysis: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.7 Molecular Diagnostics7.7.1 Overview7.7.2 Molecular Diagnostics: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)7.8 Others7.8.1 Overview7.8.2 Others: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)

8. Companion Animal Diagnostics Market Analysis - By Application8.1 Overview8.2 Companion Animal Diagnostics Market Share, by Application, 2019 and 2027 (%)8.3 Bacteriology8.3.1 Overview8.3.2 Bacteriology: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)8.4 Clinical Pathology8.4.1 Overview8.4.2 Clinical Pathology: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)8.5 Virology8.5.1 Overview8.5.2 Virology: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)8.6 Parasitology8.6.1 Overview8.6.2 Parasitology: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)8.7 Others8.7.1 Overview8.7.2 Others: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)

9. Companion Animal Diagnostics Market Analysis - By Animal Type9.1 Overview9.2 Companion Animal Diagnostics Market Share, by Animal Type, 2019 and 2027 (%)9.3 Dogs9.3.1 Overview9.3.2 Dogs: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)9.4 Cats9.4.1 Overview9.4.2 Cats: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)9.5 Horses9.5.1 Overview9.5.2 Horses: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)9.6 Others9.6.1 Overview9.6.2 Others: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)

10. Companion Animal Diagnostics Market Analysis - By End User10.1 Overview10.2 Companion Animal Diagnostics Market Share, by End User, 2019 and 2027 (%)10.3 Diagnostic Laboratories10.3.1 Overview10.3.2 Diagnostic Laboratories: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)10.4 Veterinary Hospitals and Clinics10.4.1 Overview10.4.2 Veterinary Hospitals and Clinics: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)10.5 Research Institutes and Universities10.5.1 Overview10.5.2 Research Institutes and Universities: Companion Animal Diagnostics Market- Revenue and Forecast to 2027 (US$ Million)

11. Companion Animal Diagnostics Market- Geographic Analysis11.1 North America: Companion Animal Diagnostics Market11.2 Europe: Companion Animal Diagnostics Market11.3 Asia Pacific: Companion Animal Diagnostics Market11.4 Middle East and Africa: Companion Animal Diagnostics Market11.5 South and Central America: Companion Animal Diagnostics Market

12. Impact of COVID-19 Pandemic On Global Companion Animal Diagnostics Market12.1 North America: Impact Assessment of COVID-19 Pandemic12.2 Europe: Impact Assessment of COVID-19 Pandemic12.3 Asia-Pacific: Impact Assessment of COVID-19 Pandemic12.4 Rest of the World: Impact Assessment of COVID-19 Pandemic

13. Companion Animal Diagnostics Market -Industry Landscape13.1 Overview13.2 Growth Strategies in The Companion Animal Diagnostics Market, 2016-202013.3 Inorganic Growth Strategies13.3.1 Overview13.4 Organic Growth Strategies13.4.1 Overview

14. Companion Animal Diagnostics Market - Company Profiles14.1 Zoetis Inc.14.2 Thermo Fisher Scientific Inc14.3 Virbac14.4 Shenzhen Mindray Bio-Medical Electronics Co., Ltd.14.5 Randox Laboratories, Ltd.14.6 Idvet14.7 Idexx Laboratories, Inc.14.8 Heska Corporation14.9 Fujifilm Corporation14.10 Skyla Corporation

15. Appendix

For more information about this report visit https://www.researchandmarkets.com/r/ebe5jf

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Outlook into the Worldwide Companion Animal Diagnostics Industry to 2027 - Demand for Advanced Technologies to Improve Disease Diagnosis -...

Neuroscience MARKET (IMPACT OF COVID-19) SEGMENTATION, SWOT ANALYSIS, OPPORTUNITIES AND FORECAST TO 2025 | Siemens Healthineers, Noldus Information…

Neuroscience Market 2020: LatestAnalysis

Chicago, United States The Neuroscience market report [5 Years Forecast 2020-2025] focuses on the COVID19 Outbreak Impact analysis of key points influencing the growth of the market. Providing info like market competitive situation, product scope, market overview, opportunities, driving force and market risks. Profile the Top Key Players of Neuroscience, with sales, revenue and global market share of Neuroscience are analyzed emphatically by landscape contrast and speak to info. Upstream raw materials and instrumentation and downstream demand analysis is additionally administrated. The Neuroscience market business development trends and selling channels square measure analyzed. From a global perspective, It also represents overall industry size by analyzing qualitative insights and historical data.

Global Neuroscience market report presents a complete roadmap of the products and technologies to achieve the goals of the players in the industry. Research report also offers an in depth analysis about the Agreements, collaboration and partnership among different vendors across the globe to expand the business of global Neuroscience market. Report also covers the major trends, technological advancement, opportunities which may influence the growth of global Neuroscience market. Furthermore, report also covers the risks and challenges involved for the players which might hamper the growth of the market over the forecast period.

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>>>>>>This Report Covers Leading Companies Associated in Worldwide Neuroscience Market: :GE HealthcareSiemens HealthineersNoldus Information TechnologyMightex BioscienceThomas RECORDING GmbHBlackrock MicrosystemsTucker-Davis TechnologiesPlexonPhoenix Technology GroupNeuroNexusAlpha Omega

Report Scope: Neuroscience Market

The study predicts the growth of the Neuroscience Market based on market size, market share, demand, trends and gross sales. It also focuses on the positions of large companies in relation to the competitive landscape and their individual share in the world market. The report segments the industry by product type, application and end use. It shows the latest trends and technological developments in the industry that can influence the industry. The study provides a detailed perspective on the trends observed in the market, the contributing factors, the main players, the key companies and the main areas with growth potential.

Global Neuroscience Market by Type: Whole Brain ImagingNeuro-MicroscopyElectrophysiology TechnologiesNeuro-Cellular ManipulationStereotaxic SurgeriesAnimal BehaviorOthers

Global Neuroscience Market by Application: HospitalsDiagnostic LaboratoriesResearch InstitutesOthers

Regions and Countries:U.S, Canada, France, Germany, UK, Italy, Rest of Europe, India, China, Japan, Singapore, South Korea, Australia, Rest of APAC, Brazil, Mexico, Argentina, Rest of LATAM, Saudi Arabia, South Africa, UAE.

The analysis includes market size, upstream situation, market segmentation, market segmentation, price & cost and industry environment. In addition, the report outlines the factors driving industry growth and the description of market channels.The report begins from overview of industrial chain structure, and describes the upstream. Besides, the report analyses market size and forecast in different geographies, type and end-use segment, in addition, the report introduces market competition overview among the major companies and companies profiles, besides, market price and channel features are covered in the report.

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We offer state of the art critical reports with accurate information about the future of the market.

Our reports have been evaluated by some industry experts in the market, which makes them beneficial for the company to maximize their return on investment.

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The dynamics of supply and demand shown in the report offer a 360-degree view of the market.

Our report helps readers decipher the current and future constraints of the Process Filters for the Neuroscience market and formulate optimal business strategies to maximize market growth.

NOTE: Our team is studying Covid-19 impact analysis on various industry verticals and Country Level impact for a better analysis of markets and industries. The 2020 latest edition of this report is entitled to provide additional commentary on latest scenario, economic slowdown and COVID-19 impact on overall industry. Further it will also provide qualitative information about when industry could come back on track and what possible measures industry players are taking to deal with current situation.

Table of Contents:

Study Coverage:It includes study objectives, years considered for the research study, growth rate and Process Filters for the Neuroscience market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive summary:In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Process Filters for the Neuroscience market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Process Filters for the Neuroscience Market Size by Manufacturer:Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region:It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

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Neuroscience MARKET (IMPACT OF COVID-19) SEGMENTATION, SWOT ANALYSIS, OPPORTUNITIES AND FORECAST TO 2025 | Siemens Healthineers, Noldus Information...