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U of T researchers help lead national effort to explore role of genes in COVID-19 – News@UofT

The global spread of COVID-19 has forced us to become familiar with terminology from contact tracing to social distancing most of us didnt know a few months ago. Now, if the hunch of many scientists is correct, we are about to hear a lot about genome sequencing, too.

In search of a genetic explanation for why the novel coronavirus affects some people much more severely than others, the federal government has invested $20 million into a national project to sequence and analyze the genomes of 10,000 Canadians who have had COVID-19.

The project, part of a larger $40 million investment in the Canadian COVID Genomics Network, will be managed by CGEn, a federally funded national platform for genome sequencing, a complex process that, among other things, can help spot DNA mutations in individuals or groups that predispose them to certain illnesses.

There seems to be a genetic component to this virus. You can see that in the individuals who have had the same level of exposure to the virus but respond very differently, says Lisa Strug, associate director of The Centre for Applied Genomics (TCAG) at The Hospital for Sick Children (SickKids) and an associate professor in the department of statistical sciences in the University of Torontos Faculty of Arts & Science.

That points to this idea that our genetics could impact our response to the virus and how some people can fight it off and some cant. So, we need to know what are the genetic variations that are determining this variable response?

Strug, who is scientific lead of the CGEn sequencing project, says published studies have already examined so-called heritability.

Researchers have looked at whether some of the symptoms being seen with COVID-19 run in families, she says. Some families are experiencing the virus in the same way they all have mild symptoms, or all have very severe experiences. So it appears that there is some hereditary component. And thats another piece of evidence pointing to genetics.

Strug will work with scientists at CGEn nodes at U of T and SickKids, McGill University and at the University of British Columbia. CGEn will collect blood samples from 10,000 patients from across the country, of all ages and genders, who have COVID-19. The researchers will then extract the DNA from the samples, sequence and analyze it with sophisticated computing and statistical techniques and put all the clinical and genetic information in a protected database so researchers around the world can use it in their COVID-19 projects. A similar project is being conducted in the United Kingdom, which will involve about 20,000 patients.

The large sample size is essential because there are likely different factors that contribute to the response to COVID-19 infection in different individuals and at different ages, and the more data we have, the greater the ability researchers will have to identify these, says Strug. There is a huge benefit in not just looking at one patient at a time, but across the population and across all genes.

How will this information benefit research into the novel coronavirus? Strug says the results will be useful in identifying who is the most susceptible to COVID-19 and in understanding which genes scientists should be targeting when developing drugs to treat the virus and, ideally, a vaccine that will help control it.

There is also another major benefit of starting this massive, two year-long project immediately: data that can be used to protect ourselves from future illnesses.

U of Ts StephenScherer,the lead principal investigator of CGEn,says the genetic information gleaned from the project can be used to help guard against future outbreaks (photo courtesy of SickKids)

This is Canadas first time doing a large-scale project like this, says Stephen Scherer, TCAGs director and a University Professor of molecular genetics at U of T. When global society moves past the COVID-19 pandemic, there will be another one. All this genetic information will be extremely useful for that point in the future.

Were about to get an excellent genetic cross-section of the Canadian population. This virus has been destructive, but it is also forcing us to create new knowledge that we will be able to leverage for years to come.

For example, knowledge gained from the SARS epidemic of the early 2000s has been useful during the current outbreak, according to Strug and Scherer. Thats because of the similarities between the two coronaviruses.

That has helped the global research community be able to respond quickly to this new virus, says Strug.

That said, genetic sequencing must deal with a huge amount of data. The numbers are staggering the human genome contains three billion base chemical units that code for about 25,000 to 35,000 genes, and this project will sequence 10,000 genomes.

This is very big data analysis, Strug says.

Both scientists note that computing technology used for sequencing is far more advanced than even a decade ago. The technology has become so sophisticated and affordable that we can propose to look at entire DNA sequences, says Scherer. In 2003, for SARS 1, we couldnt do this.

Scherer, who is the lead principal investigator of CGEn, a senior scientist at SickKids and director of U of Ts McLaughlin Centre, says hes impressed with how the global research community has pivoted to focus on solving the COVID-19 puzzle.

Its amazing how scientists around the world have come together on this, he says. Just at U of T, there are researchers working on COVID-19 who I would have never predicted would be. I would say that 75 per cent of the people Im talking with every day, now, are not the same people I was talking with eight weeks ago. But they have a specific technology or some useful knowledge that links in.

Thats how scientific research needs to work to be effective: By bringing in a wide breadth of perspectives and specialists, cracking COVID-19 could become this generations moonshot.

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U of T researchers help lead national effort to explore role of genes in COVID-19 - News@UofT

Chitosan Market Size Worth $28.93 Billion by 2027 | CAGR 24.7%: Grand View Research, Inc. – PRNewswire

SAN FRANCISCO, May 25, 2020 /PRNewswire/ -- The global chitosan marketsize is projected to reach USD 28.93 billion by 2027, according to a new report by Grand View Research, Inc. It is expected to expand at a revenue-based CAGR of 24.7% during the forecast period. Increasing consumption of bio-derived products in water treatment, cosmetics, food and beverage, and pharmaceutical industries is likely to derive the growth.

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Read 102 page research report with ToC on "Chitosan Market Size, Share & Trends Analysis Report By Application (Pharmaceutical & Biomedical, Water Treatment, Cosmetics, Food & Beverage), By Region (APAC, North America, Europe, MEA), And Segment Forecasts, 2020 - 2027" at: https://www.grandviewresearch.com/industry-analysis/global-chitosan-market

Chitosan is marketed under various grades, such as industrial, pharmaceutical, and food depending upon the purity of the product. In the pharmaceutical industry, it is used as diluents for tablets, a binder in wet granulations, dis-integrant, drug carrier, and absorption enhancer. In addition, chitosan and its derivatives can easily penetrate the plasmatic membrane of microorganisms and kill bacteria, fungi, and other parasites. Hence, is used for treating infections in orthopedic, neurological, gynecological, and cardiovascular surgical procedures.

North America is expected to emerge as one of the major markets for chitosan during the forecasted period, registering a CAGR of 19.2% in terms of volume, between 2020 to 2027. The region has experienced a growing demand for chitosan products owing to increasing biobased industries. Manufacturers are heavily investing in R&D activities to develop the pure grade of chitosan. However, high production cost owing to the irregular supply of the raw material is anticipated to hamper market growth over the forecast period.

The market is highly fragmented in nature owing to the presence of a large number of small-scale players, especially in countries including Japan, China, Thailand, and South Korea. These countries have favorable government regulations to promote growth of their fishery industry. Hence, several companies such as Qingdao Yunzhou Biochemistry Co., Kyowa Technos Co., Ltd., Dainichiseika Color & Chemicals Mfg. Co. Ltd., and KIMICA Corporation have manufacturing as well as distribution channels present in the region.

Grand View Research has segmented the global chitosan market on the basis of application and region:

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Chitosan Market Size Worth $28.93 Billion by 2027 | CAGR 24.7%: Grand View Research, Inc. - PRNewswire

Research Roundup: Emerging Viral Diseases and More – BioSpace

Every week there are numerous scientific studies published. Heres a look at some of the more interesting ones.

More Worries About Emerging Viral Diseases

If the current COVID-19 pandemic is teaching the world anything, its that viral diseases can be extremely dangerous and disruptive. Researchers with the University of Colorado Anschutz Medical Campus released a new study calling attention to the emergence of mosquito-borne viral outbreaks in West Africa, including dengue (DNV), chikungunya (CHIKV) and Zika (ZIKV) viruses. They published their research in Acta Tropica.

The study reviewed 50 years of literature on arboviruses in West Africa. The goal was to define evidence of DENV, ZIKV and CHIKV and the distribution of their Aedes mosquito vectors in the region. They found strong evidence that transmission of these diseases is occurring in urban areas of West Africa, which is distinct from the rural transmission of yellow fever virus that has been historically present in the region. They found evidence that the epidemiology of arboviral disease in West Africa has shifted and that rapid urbanization and climate change could increase risk of outbreaks in the future.

Large arboviral outbreaks will occur around the world, said Elizabeth Carlton, assistant professor of environmental and occupational health at the Colorado School of Public Health and co-author of the study. Building awareness and surveillance capacity before the outbreaks occur can help detect outbreaks early and enable prompt and effective response to reduce health impacts.

Research lead Andrea Buchwald, a postdoctoral fellow, said, Emerging viruses are at the forefront of everyones attention due to the COVID-19 pandemic. It has underscored the importance of preparing for and preventing large viral outbreaks that can have massive public health and economic consequences. We hope our research will prompt the development of early warning systems and adoption of control measures to prevent infectious outbreaks in West Africa. This will greatly impact the spread and severity of future outbreaks.

Vaccine Design Leveraging Artificial Proteins

Investigators at Ecole Polytechnique Federale de Lausanne in France developed a computational approach to create artificial proteins, which they believe could be used to create safer and more effective vaccines. They note that when vaccines dont work, theres a tendency to think its because the antibodies produced arent protective, but usually its because the immune system is making the wrong type of antibodies. The new method was able to design artificial proteins that could precisely instruct the bodys immune system which antibodies to produce.

New Genetic Link for NASH Identified

Non-alcoholic steatohepatitis is a fatty liver disease similar to cirrhosis of the liver but in people who drink little or no alcohol. Researchers at German Diabetes Center, German Institute of Human Nutrition Potsdam-Rehbrucke (DlfE), and Helmholtz Zentrum Munchen, discovered new genes that play a role in fatty liver disease. The genes are IRGM, Ifgga2 and Ifgga4. They are responsible for the production of regulatory proteins of the family of immunity-related GTPases that counteract fat accumulation in the liver. A genetic variation causes formation of fewer of these proteins.

University of Waterloo researchers studying the 3D structure of the COVID-19 protein believe a specific class of diabetes drugs could potentially be used to treat COVID-19. The study has not yet been peer-reviewed, but they found evidence that dipeptidyl peptidase 4 inhibitors (DPP4 inhibitors) could bind to the protein. They are continuing research and hope to scale up to clinical trials. Common DPP4 inhibitors include AstraZenecas Onglyza (saxagliptin), Mercks Januvia (sitagliptin), Takedas Nesina (alogliptin) and Boehringer Ingelheims Tradjenta (linagliptin).

How Triglyceride is Made

Triglycerides are a type of dietary fat that are associated with increased risk of heart disease, diabetes, obesity and fatty liver disease. Researchers at Baylor College of Medicine identified a 3D structure and mode of action of an enzyme, acylglycerol O-acyltransferase-1 (DGAT1) that synthesizes triglycerides. It is also required for human dietary fat absorption and storage. DGAT1 is a known target for treating diabetes and metabolic diseases, so understanding the mechanism of action may lead to better interventions. The research was published in the journal Nature.

DGAT1 is a particularly interesting enzyme because it synthesizes triglycerides, which are the main component of hard fat, the type of fat usually found in the belly or midsection in our body, said co-corresponding author Ming Zhou, Ruth McLean Bowman Bowers Professor in Biochemistry in the Department of Biochemistry and Molecular Biology at Baylor. Triglycerides also are part of the particles that transport cholesterol high-density lipoproteins (HDL, or good cholesterol), and low-density and very-low-density lipoproteins (LDL and VLDLD, or bad cholesterols). Learning to regulate this enzyme can help regulate fat synthesis and potentially manage related conditions.

Accumulated Neuron Damage as We Age

Researchers at Massachusetts Institute of Technology (MIT) identified an enzyme called HDAC1 that is critical for repairing age-related DNA damage in genes associated with memory and cognition. In Alzheimers patients, as well as in normally aging adults, HDAC1 is often found in lower amounts. Their research suggests that restoring the enzyme could have benefits for both groups. The research was published in the journal Nature Communications.

It seems that HDAX1 is really an anti-aging molecule, said Li-Huei Tsai, director of MITs Picower Institute for Learning and Memory, and senior author of the research. I think this is a very broadly applicable basic biology finding, because nearly all of the human neurodegenerative diseases only happen during aging. I would speculate that activating HDAC1 is beneficial in many conditions.

In 2013, the same group published two papers linking HDAC1 to DNA repair in brain cells. The new research studied what happens when HDAC1-mediated repair didnt happen. They worked with mice engineered to not produce HDAC1 in neurons and another type of brain cell, astrocytes. At first there was no noticeable difference in DNA damage levels or behavior, but as the mice aged, DNA damage began to accumulate in the HDAC1-deficient mice and lost some of their brain plasticity and problems in memory and spatial navigation. The loss of HDAC1 was associated with a specific type of DNA damage called 8-oxo-guanine lesions.

Link:
Research Roundup: Emerging Viral Diseases and More - BioSpace

Neuroscience Antibodies & Assays Market 2020 Global Overview, Growth, Size, Opportunities, Trends, Leading Company Analysis and Forecast to 2026 -…

Abcam

All of the product type and application segments of the Neuroscience Antibodies & Assays market included in the report are deeply analyzed based on CAGR, market size, and other crucial factors. The segmentation study provided by the report authors could help players and investors to make the right decisions when looking to invest in certain market segments.

The Essential Content Covered in the Neuroscience Antibodies & Assays Market Report :

* Top Key Company Profiles.* Main Business and Rival Information* SWOT Analysis and PESTEL Analysis* Production, Sales, Revenue, Price and Gross Margin* Market Share and Size

The report is a compilation of different studies, including regional analysis where leading regional Neuroscience Antibodies & Assays markets are comprehensive studied by market experts. Both developed and developing regions and countries are covered in the report for a 360-degree geographic analysis of the Neuroscience Antibodies & Assays market. The regional analysis section helps readers to become familiar with the growth patterns of important regional Neuroscience Antibodies & Assays markets. It also provides information on lucrative opportunities available in key regional Neuroscience Antibodies & Assays markets.

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Table of Content

1 Introduction of Neuroscience Antibodies & Assays Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Neuroscience Antibodies & Assays Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Neuroscience Antibodies & Assays Market, By Deployment Model

5.1 Overview

6 Neuroscience Antibodies & Assays Market, By Solution

6.1 Overview

7 Neuroscience Antibodies & Assays Market, By Vertical

7.1 Overview

8 Neuroscience Antibodies & Assays Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Neuroscience Antibodies & Assays Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Why do opposites attract, and can we change our political leanings as we grow older? Neuroscience has the answers – The Canberra Times

life-style, books,

We all know at least one couple who just make no sense, a perplexing pairing that irks and boggles us. One of them might be vivacious, gregarious, classically attractive and yet the other is a little freeze ray of misery and seems to despise socialising. So why, oh why, are they together? Neuroscience, according to Dr Hannah Critchlow, may have the answer to this eternal question, and plenty more - why we get more opinionated and closed minded as we age, how our political leanings are formed, why some couples don't even seem to like each other much. Critchlow, a British researcher, writer and broadcaster who has been described as "the female Brian Cox", lays out in her brain-bending book - The Science of Fate - just some of the recent research into determinism and the theory that we don't so much make our own decisions as inherit them. The fast-moving field of modern neuroscience will, she believes, "one day be considered as profound as Darwin's Theory of Evolution". So, what can the brain tell us about the laws of opposite attraction? Well, there's a lot more to love than what meets our eyes, and it may well involve senses we didn't know we were even using. "Scientists used to believe we only had five senses, but we're finding more and more we didn't know we had, through experiments, all the time," explains Critchlow, who found herself "happily stuck" in Noosa by the coronavirus lockdown while on an Australian book tour. One fascinating trial, carried out at the Zoological Institute at Bern University and later replicated in the US, showed that women may actually be turning the smell of potential male partners into complex information. Researchers asked men to wear the same T-shirt for a few days without washing, deodorising or eating smelly foods. A group of women were then given the appetising task of sniffing the shirts and rating them for attractiveness. The results clearly showed that women would choose the odour of men whose immune systems were highly differentiated from their own. Finding a mate with different gene variations from your own produces the strongest possible offspring; a child with the greatest resistance to a wide range of infections, and thus the best chance of survival. Just how women were able to detect their biological ideal man using optimum genetics via the smell of a stinky armpit is "quite mysterious", as Critchlow understates it. "But we are, at some level, just animals, driven by the single desire to interact in a way that will pass on our genetic material," she says. "Love, it seems, is largely a by-product of the brain circuitry that prioritises reproduction and the survival of the species." Interestingly, the sniff test does not work with men, but boys are not without their own mysteries. A study of thousands of lap dances in the US found that strippers would make almost twice as much in tips on the few days when they were at the most fertile point of their menstrual cycle. Somehow, the men just found them more attractive on those days, without having any idea why. "When it comes to sex, it seems that a choice that may feel highly personal and deeply intimate is, to a large extent, the behavioural result of our brains' coding to seek maximum opportunities for our genes to be passed on," Critchlow says. Like many of her colleagues, she has come to accept that many of the choices we make are hugely influenced by the genes given to us by our parents, and our grandparents' parents. Even the foods we like are choices driven by what our ancestors were eating, and enjoying. "Basically, we are designed to eat food when we can get it, because there might not be any around tomorrow, but now we live in a world where many of us can have whatever we want, whenever we want it, which obviously leads to obesity," she says. "Genetic mutations to encourage eating less weren't passed on because food was scarce and there was no advantage in that. Mutations that made us eat as much as possible in case there was no more are a problem now that we live in abundance. "Evolution has not caught up with Uber Eats." The reassuring sense we have that we are making our own choices is "just our brains messing with us", in much the same way that we like to perceive the sun as "rising" and "setting", when we know, scientifically, that it is just the world turning. "There is always scope for changing your mind, this is the basis for consciousness, but it's not as big as we perceive it - that scope to change is limited based on the genetics we've been given," Critchlow says. "Remember that our brains use 20 per cent of our daily energy quota to fuel this enormous circuit board, and to save energy your brain filters a lot of information, and makes assumptions, based on past experience. "Judging people in the first few minutes that we meet them is all about saving energy. "With friendship groups, or clans, people look for individuals with a similar outlook and who have similar genetics as well (unlike the way they look for sexual partners). "You are drawn to people, friends, who are genetically similar to you, so you are more likely to see the world in the same way and have the same biases. "You're saving energy because you don't have to explain things." Speaking of biases, just think how reassuring it would be to discover that people who hold political views that strike you as unjustifiable were just born that way. As Critchlow puts it, understanding that people believe in certain things, like religion or politics, because their brains were built that way, "might have massive consequences for reducing conflict at every level - as we discover more about the neurobiology of belief formation and prejudice, we might be able to boost our openness to new ideas". She quotes the work of Jonas Kaplan, Professor of Psychology at USC's Brain and Creativity Institute, who has found that activity in the amygdala, and the size of people's anterior cingulate cortex, can be used to predict whether they are liberal or conservative. His researchers were able to use brain scans to predict the political leanings of American test subjects - whether they voted Republican or Democrat - "with high sensitivity and accuracy". "It's quite incredible and it does help me to understand people a little bit more, because those who are more liberal have a less-sensitive amygdala are more able to think about collaborations and partnerships for the future, rather than being scared in the moment," Critchlow says. "Conservative types have a more reactive amygdala, and that gives them a heightened reactivity to fear. They assess risks and react conservatively. "But the fact is, both types of people are really important for our survival as a species. If we were all one type it would be a disaster, we wouldn't have moved forward as a species." This, of course, raises the interesting quote most often wrongly attributed to Winston Churchill: "if you're not a liberal when you're 25, you have no heart , if you're not a conservative by the time you're 35, you have no brain." Why would people's leanings change as they age? "There's been some research at Oxford into that, following people from the 1960s to see whether they got more conservative as they got older, and it showed a 20-point increase in conservatism by the time they were 80 years old," Critchlow says. "As you get older, you rely on more tried and tested routes within your mind, there is slightly less potential for plasticity, so you might become more risk averse. "You also start to weigh how you process information differently; you place less weight on signals from the outside world, and more weight on the internal capacity of your mind - the information you have stored there. "In a way, older people are not really listening to new ideas, because they take too much energy. They're relying on their own, refined information. Or what we think of as wisdom." Kaplan, from USC, provides the quote in The Science of Fate that most neatly sums up the way most neuroscientists now see the world, which sounds radical to most people but is, Critchlow says, very much the accepted wisdom in her academic milieu. "I don't believe in free will. The universe is deterministic,'' Kaplan says. "We aren't the authors of our own actions, because everything is caused by something prior." He is aware, however, that unlike scientists, many people would find this idea hard to live with, and adds: "Decisions are partially controlled by our emotional state, and most people find it depressing to believe that they have little or no free will, so there is a lot of value in believing in it." Critchlow says abandoning the idea of free will can actually be quite relaxing. She says she frets less about the way she parents her young son, because she's not sure there's much point worrying about it. "I tend to forget that most people don't think this way and I was chatting with my agent recently and she said 'So hang on, you really think we're really just like machines?' And I was like, 'oh yeah, that's what all of the people in my little bubble of neuroscientists think'," she says. "But I think it's an idea that will become more accepted, and it's starting to happen. "Don't forget that Darwin's theories were pretty radical there for a while."

https://nnimgt-a.akamaihd.net/transform/v1/crop/frm/9gmjQxX8MpSQh6J68NHMnY/97fc079b-a059-4a2f-a1e9-c7ff49cbd985.jpg/r74_0_5021_2795_w1200_h678_fmax.jpg

We all know at least one couple who just make no sense, a perplexing pairing that irks and boggles us. One of them might be vivacious, gregarious, classically attractive and yet the other is a little freeze ray of misery and seems to despise socialising. So why, oh why, are they together?

Neuroscience, according to Dr Hannah Critchlow, may have the answer to this eternal question, and plenty more - why we get more opinionated and closed minded as we age, how our political leanings are formed, why some couples don't even seem to like each other much.

Critchlow, a British researcher, writer and broadcaster who has been described as "the female Brian Cox", lays out in her brain-bending book - The Science of Fate - just some of the recent research into determinism and the theory that we don't so much make our own decisions as inherit them. The fast-moving field of modern neuroscience will, she believes, "one day be considered as profound as Darwin's Theory of Evolution".

So, what can the brain tell us about the laws of opposite attraction? Well, there's a lot more to love than what meets our eyes, and it may well involve senses we didn't know we were even using.

"Scientists used to believe we only had five senses, but we're finding more and more we didn't know we had, through experiments, all the time," explains Critchlow, who found herself "happily stuck" in Noosa by the coronavirus lockdown while on an Australian book tour.

One fascinating trial, carried out at the Zoological Institute at Bern University and later replicated in the US, showed that women may actually be turning the smell of potential male partners into complex information.

Researchers asked men to wear the same T-shirt for a few days without washing, deodorising or eating smelly foods. A group of women were then given the appetising task of sniffing the shirts and rating them for attractiveness.

The results clearly showed that women would choose the odour of men whose immune systems were highly differentiated from their own. Finding a mate with different gene variations from your own produces the strongest possible offspring; a child with the greatest resistance to a wide range of infections, and thus the best chance of survival.

Dr Hannah Critchlow, author of The Science of Fate. Picture: Simon Weller

Just how women were able to detect their biological ideal man using optimum genetics via the smell of a stinky armpit is "quite mysterious", as Critchlow understates it.

"But we are, at some level, just animals, driven by the single desire to interact in a way that will pass on our genetic material," she says.

We are, at some level, just animals, driven by the single desire to interact in a way that will pass on our genetic material.

"Love, it seems, is largely a by-product of the brain circuitry that prioritises reproduction and the survival of the species."

Interestingly, the sniff test does not work with men, but boys are not without their own mysteries. A study of thousands of lap dances in the US found that strippers would make almost twice as much in tips on the few days when they were at the most fertile point of their menstrual cycle. Somehow, the men just found them more attractive on those days, without having any idea why.

"When it comes to sex, it seems that a choice that may feel highly personal and deeply intimate is, to a large extent, the behavioural result of our brains' coding to seek maximum opportunities for our genes to be passed on," Critchlow says.

Like many of her colleagues, she has come to accept that many of the choices we make are hugely influenced by the genes given to us by our parents, and our grandparents' parents. Even the foods we like are choices driven by what our ancestors were eating, and enjoying.

"Basically, we are designed to eat food when we can get it, because there might not be any around tomorrow, but now we live in a world where many of us can have whatever we want, whenever we want it, which obviously leads to obesity," she says.

"Genetic mutations to encourage eating less weren't passed on because food was scarce and there was no advantage in that. Mutations that made us eat as much as possible in case there was no more are a problem now that we live in abundance.

"Evolution has not caught up with Uber Eats."

The reassuring sense we have that we are making our own choices is "just our brains messing with us", in much the same way that we like to perceive the sun as "rising" and "setting", when we know, scientifically, that it is just the world turning.

"There is always scope for changing your mind, this is the basis for consciousness, but it's not as big as we perceive it - that scope to change is limited based on the genetics we've been given," Critchlow says.

"Remember that our brains use 20 per cent of our daily energy quota to fuel this enormous circuit board, and to save energy your brain filters a lot of information, and makes assumptions, based on past experience.

"Judging people in the first few minutes that we meet them is all about saving energy.

Abandoning the idea of free will, and leaving everything to fate, can actually be quite relaxing. Picture: Shutterstock

"With friendship groups, or clans, people look for individuals with a similar outlook and who have similar genetics as well (unlike the way they look for sexual partners).

"You are drawn to people, friends, who are genetically similar to you, so you are more likely to see the world in the same way and have the same biases.

"You're saving energy because you don't have to explain things."

Speaking of biases, just think how reassuring it would be to discover that people who hold political views that strike you as unjustifiable were just born that way.

As Critchlow puts it, understanding that people believe in certain things, like religion or politics, because their brains were built that way, "might have massive consequences for reducing conflict at every level - as we discover more about the neurobiology of belief formation and prejudice, we might be able to boost our openness to new ideas".

She quotes the work of Jonas Kaplan, Professor of Psychology at USC's Brain and Creativity Institute, who has found that activity in the amygdala, and the size of people's anterior cingulate cortex, can be used to predict whether they are liberal or conservative.

His researchers were able to use brain scans to predict the political leanings of American test subjects - whether they voted Republican or Democrat - "with high sensitivity and accuracy".

"It's quite incredible and it does help me to understand people a little bit more, because those who are more liberal have a less-sensitive amygdala are more able to think about collaborations and partnerships for the future, rather than being scared in the moment," Critchlow says.

"Conservative types have a more reactive amygdala, and that gives them a heightened reactivity to fear. They assess risks and react conservatively.

"But the fact is, both types of people are really important for our survival as a species. If we were all one type it would be a disaster, we wouldn't have moved forward as a species."

This, of course, raises the interesting quote most often wrongly attributed to Winston Churchill: "if you're not a liberal when you're 25, you have no heart , if you're not a conservative by the time you're 35, you have no brain." Why would people's leanings change as they age?

"There's been some research at Oxford into that, following people from the 1960s to see whether they got more conservative as they got older, and it showed a 20-point increase in conservatism by the time they were 80 years old," Critchlow says.

"As you get older, you rely on more tried and tested routes within your mind, there is slightly less potential for plasticity, so you might become more risk averse.

"You also start to weigh how you process information differently; you place less weight on signals from the outside world, and more weight on the internal capacity of your mind - the information you have stored there.

"In a way, older people are not really listening to new ideas, because they take too much energy. They're relying on their own, refined information. Or what we think of as wisdom."

Kaplan, from USC, provides the quote in The Science of Fate that most neatly sums up the way most neuroscientists now see the world, which sounds radical to most people but is, Critchlow says, very much the accepted wisdom in her academic milieu.

"I don't believe in free will. The universe is deterministic,'' Kaplan says.

"We aren't the authors of our own actions, because everything is caused by something prior."

He is aware, however, that unlike scientists, many people would find this idea hard to live with, and adds: "Decisions are partially controlled by our emotional state, and most people find it depressing to believe that they have little or no free will, so there is a lot of value in believing in it."

Critchlow says abandoning the idea of free will can actually be quite relaxing. She says she frets less about the way she parents her young son, because she's not sure there's much point worrying about it.

"I tend to forget that most people don't think this way and I was chatting with my agent recently and she said 'So hang on, you really think we're really just like machines?' And I was like, 'oh yeah, that's what all of the people in my little bubble of neuroscientists think'," she says.

"But I think it's an idea that will become more accepted, and it's starting to happen.

"Don't forget that Darwin's theories were pretty radical there for a while."

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Why do opposites attract, and can we change our political leanings as we grow older? Neuroscience has the answers - The Canberra Times

Harpurs Ferry members continue their work at home – Binghamton University

By Sophia Cavalluzzi

May 18, 2020

A volunteer, student-run ambulance service, Harpurs Ferry has been a crucial asset to Binghamton University since the 1970s. Since the transition to virtual learning, many of its members have gone back to their hometowns but they didnt leave their volunteer work in Binghamton.

Members of Harpurs Ferry are serving as EMS staff in their respective hometowns, responding to COVID-19 patients. Sophomore integrative neuroscience major Kristen Coletti went home to Long Island, but has been working in New York City, the epicenter of the pandemic.

Im currently working at a hotel in Times Square that houses homeless COVID-19 positive patients, Coletti said. Its been a very humbling experience that has allowed me to reflect on my own life and things I take for granted each day.

Jared Frick left his home in Albany to provide aid in Rockland County. Image Credit: Provided.

The struggles I face working here are nothing compared to what the community is facing, Frick said. The situation is leaving certain populations, like the elderly, with an incredibly difficult decision to make that, for many, is ending up in a death sentence.

While healing patients and worrying about their own personal health, members of Harpurs Ferry are also managing to stay on top of their schoolwork during the final weeks of the semester.

Im taking 22 credits at Binghamton this semester, so my course load was already a bit heavy, but not overwhelming, Frick said. The faculty here have been incredibly understanding of my situation, and I cant express my appreciation for them enough.

Lexis Rosenberg has been working in Rockland County, her hometown area. Image Credit: Provided.

When we were transporting a patient from the hospital to a rehab center after fighting COVID-19, the hospital played Fight Song as we were leaving and a bunch of nurses and doctors lined up and were cheering for the patient, she said. I know for the patient and me that it felt amazing; that there is hope.

Logan Strobing is working in Merrick, Long Island, feeling lucky to be getting through all of this with amazing coworkers.

Experiencing this with them has definitely made us closer, said Strobing. Additionally, its extremely rewarding when you know you made a positive impact on someones day. First responders have been getting so much love from everyone right now, and it definitely makes a difference.

Coletti is also realizing her part in the bigger picture.

The biggest reward is realizing that Im part of something bigger than myself, she said. When I commute into Manhattan and I see all of the other essential workers heading to their jobs, I find myself thinking about the millions of people that are putting themselves at risk every day for the health of our country.

Harpurs Ferry students, risking their own health to help their communities, are doing it all, and doing it well.

If youre worried or feeling stressed during this time, take it from Strobing: There is a light at the end of the tunnel; we just have to endure this together!

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Harpurs Ferry members continue their work at home - Binghamton University

UA scientists discover new role for protein involved in neurodegeneration – Arizona Daily Wildcat

Researchers in the lab of Martha Bhattacharya, an assistant professor of neuroscience at the University of Arizona, have linked a gene involved in axon degeneration to the itch sensation in mice, attracting interest from the agribusiness industry.

A recent faculty transfer from Washington University in St. Louis, Ill., Bhattacharya heads a lab that studies the communication between neurons, the cells responsible for sending electrical signals throughout our bodies, and non-neuronal cells during the progression of neurodegenerative diseases in fruit flies and mice. Her research is supported by the National Institutes of Health.

The majority of our lab is still focused on the TMEM184B gene, Bhattacharya said. Now, we are using fruit flies to look at this gene's effect on synapses and signaling too.

Bhattacharyas most recent publication, now available on bioRxiv, linked TMEM184B to the initiation of developmental signals critical to the specification of pruriceptive, or itch sensing, neurons in mice.

In future studies, Bhattacharya hopes to characterize the role of this gene in the maintenance of these itch-sensing pathways and synapses in adults, linking TMEM184B's newly discovered function in itch sensation to its ability to promote apoptosis or neuron degeneration.

Beyond TMEM184B, Bhattacharya is also utilizing fruit flies to identify new genes involved in the communication between neurons and astrocytes, a support cell that regulates neuronal signals, during the progression of various neurodegeneration diseases such as Alzheimers and Parkinsons disease. Once identified, Bhattacharya plans to purse these genes roles in the nervous system as she has done with TMEM184B.

In addition to a hardworking team of graduate students and research technicians, Bhattacharya also places a focus on mentoring undergraduate students on projects in her lab.

I want my undergraduate students to learn how to ask questions that are testable and controllable, Bhattacharya said. From my own personal experience, having a group of people grappling with unknown questions in a lab is a really exciting place to be.

Beyond their individual projects, Bhattacharya hopes she can inspire the next generation of scientists by providing students an environment to see science in action and realize that all of the chapters in their textbooks are still being written; there is still so much to contribute.

Hannah Hart, a neuroscience and cognitive science junior, has worked as an undergraduate researcher in the Bhattacharya lab for the last year.

"Dr. Bhattacharya has been an amazing mentor and friend," Hart said. "She encourages me to step outside of the box, be risky and learn from any mistakes. She always supports any achievements and inspires me continuously to try as hard as I can."

The focus on undergraduate research and mentorship in the Neuroscience and Cognitive Science Department at the UA was a big reason Bhattacharya moved her lab to Tucson.

Outside of her research, Bhattacharya also designed and teaches a course exploring neurodevelopment, or in other terms, what it takes an organism or potentially a scientist to build a brain from scratch.

Teaching an upper-division course, I do not have to worry about whether or not I covered all the necessary topics for my students to take the MCAT, Bhattacharya said. I make sure the topics I cover are interesting not only to me but are linked to health and medicine.

Bhattacharyas interest in neuroscience began with a sensory neuroscience course in college and flourished when she attended graduate school at the University of California, San Francisco researching neurodevelopment and the molecular mechanisms of the sense of touch.

According to Bhattacharya, many of the molecular pathways linked to the neurodegenerative diseases she now studies were first discovered and characterized in the context of neurodevelopment. Adding a neurodevelopment course to the UA's schedule was a must, Bhattacharya said.

For example, Bhattacharya's own lab primarily studies neurodegeneration, but her research on the functions of TMEM184B within the nervous system led her research back to her neurodevelopment roots and the itch sensation of mice.

Throughout her career, Bhattacharya married and started a family. She now has two kids.

When my kids were very young, that was the hardest window of time, Bhattacharya said. Being a faculty member means you are no longer in just the lab, you need a calendar for all your meetings and new work.

Bhattacharya attributes some of her success to maintaining passions outside of science, like biking and running, and a mindset that not everything will go right the first time. She said success is more hard work than perfection.

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UA scientists discover new role for protein involved in neurodegeneration - Arizona Daily Wildcat

Stroke Myths: Find Out the Facts – hellowoodlands.com

May is National Stroke Awareness Month. Did you know? Someone in the U.S. has a stroke every 40 seconds, and dies from stroke every four minutes. You can help combat this killer by arming yourself with the facts.

Memorial Hermann Mischer Neuroscience Associates, and UTHealth Neurosciences physicians affiliated with Memorial Hermann Mischer Neurosciences are setting the record straight on common stroke myths.

Read the answers; following are the myths:

While they share many of the same risk factors, a heart attack affects the heart, while a stroke affects the brain. A stroke occurs when blood flow to the brain is interrupted, depriving brain tissue of oxygen.

There are two major types of stroke; Hemorrhagic stroke occurs when a blood vessel in the brain bursts, resulting in bleeding in the surrounding tissue. Ischemic stroke occurs when a blood clot blocks a vessel carrying blood to the brain, cutting off blood supply to the brain.

While genetic factors can contribute to stroke risk, up to 80 percent of strokes are preventable by managing risk factors. To prevent stroke, maintain healthy blood pressure, cholesterol and blood sugar levels. Maintain a healthy body weight. Get regular exercise. And also, please dont smoke.

Ischemic stroke can be treated with a clot-busting drug called tissue plasminogen activator (tPA), which must be administered within 3 to 4.5 hours of the onset of stroke. Certain types of ischemic stroke can be treated by prescribing medication, surgically removing the blood clot or repairing the ruptured blood vessel.

A transient ischemic attack (TIA), is a medical emergency that occurs when stroke symptoms last less than 24 hours without treatment. A TIA is a very strong predictor of a stroke; a person who has suffered one or more TIAs is almost 10 times more likely to have a stroke.

Your risk for stroke increase with age, but a stroke can occur at any age. In fact, the rate of stroke among people between the ages of 18 and 65 is on the rise, given increases in obesity, elevated cholesterol, diabetes and high blood pressure among this population.

Strokes run in families, as many of the chronic diseases that put a person at a higher risk for strokeincluding hypertension, diabetes and obesityrun in families. In addition, certain genetic conditions can run in families, which increase the risk of forming blood clots that can lead to stroke.

While most of the healing takes place in the first few months after a stroke, recoverythrough physical therapy and other treatmentscan continue for years.

Aspirin is used to prevent ischemic strokes in people who have either already had a stroke, or who have risk factors for stroke. Aspirin can actually worsen a hemorrhagic stroke. If you experience stroke symptoms, avoid taking aspirin and call 911 immediately.

Both the Joint Commission and Det Norske Veritas (DNV) certify hospitals that meet certain standards for care of acute stroke, designating them as Comprehensive Stroke Centers (CSCs) and Primary Stroke Centers (PSCs). While both are advanced designations, CSCs are the most advanced.

For more information or to schedule an appointment with a neurologist in The Woodlands, visit memorialhermann.org/stroke or call 713.897.5900.

Source: Memorial Hermann Health System

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Plum High School teacher selected to be a part of state science committee – Plum – TribLIVE

Saturday, May 23, 2020 | 9:01 AM

Plum High School teacher Shubhada Bhamre was recently selected to be on a state Department of Education committee to update state science standards.

A Plum High School teacher has been selected to be on a state Department of Education committee examining new state science standards.

Biologist Shubhada Bhamre said shes excited to be on the 10-member panel called PA Academic Standards for Science and Technology, Environment and Ecology Content Committee.

I love biology, (and) my content knowledge is very good, she said. Im very much interested in furthering the education both of students and teachers.

In September 2019, the State Board of Education directed the state Education Department to begin the process of updating Pennsylvanias science standards to align them with current research and best practices, including a review of Next Generation Science Standards.

The committees work starts June 16.

Members will meet in six full-day virtual sessions. Their report is expected to be used in drafting science standards that provide educators across the state a guide for science-specific content needs.

These days the focus is not just on one specific content area, but of a cross-curricular nature, Bhamre said. When I look at the list (of committee members), there are people from universities. There are people from hardcore education backgrounds. Theres a mix of middle and high school teachers. There are general science as well as content area teachers. Its all the sciences.

Bhamre, of Oakmont has been with the district about 17 years.

She studied science in India and earned a doctorate in neuroscience with a sub-speciality in neurochemistry from the National Institute of Mental Health and Neurosciences in Bangalore, India. She also has a masters in developmental biology.

She migrated to the United States in 1994 and had post-doctorate fellowships at the University of Texas Health Science Center in San Antonio , at Hahnemann University Hospital in Philadelphia and at Childrens Hospital of Pittsburgh. She earned her teaching certification from the University of Pittsburgh.

This will be Bhamres first time on a state committee, but not the only time her input was used in potentially influencing science education in Pennsylvania.

Bhamre said she had submitted feedback and item analysis in the past to the Education Department and Data Recognition Corp. in regards to the Keystone exams.

Other committee members include:

Rebecca Thomas, assistant professor of park resource management at Slippery Rock University;

Rick Zilla, Greenville Area School District high school technology education teacher;

Sharon Brusic, professor at Millersville University of Pennsylvania;

Steve Kerlin, director of environmental education at Stroud Water Research Center;

Steve Wasiesky, environmental education coordinator at Millcreek Township School District;

Tarrea Potter, state education outreach coordinator at the Chesapeake Bay Foundation;

Timothy Dzurko, middle school technology education and STEM teacher at State College Area School District;

Travis Martin, middle school science teacher at Bellwood-Antis School District;

Tyler Love, assistant professor of education and director of the Capital Area Institute for Math and Science at Penn State Harrisburg.

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Plum High School teacher selected to be a part of state science committee - Plum - TribLIVE

Marcus A. Henry Award past winners: Where are they now? – Newsday

2014: JOE PERCIVAL,St. Anthonys

Joe Percival has experienced unfathomable turmoil, but hes seemed to have found his true calling.

In November 2013, after captaining the defense for St. Anthonys state championship football team, his mother Valerie was scheduled for brain surgery for the removal of two benign tumors. But she had a severe allergic reaction to an antibiotic she was given designed to prevent meningitis, and was in a coma for six months.

Percival found a way to push forward and struck the balance of being a two-sport athlete (football and track), diligent student and an exceptional citizen all the while caring for his mother.

The Melville native was the inaugural recipient of the Marcus A. Henry Award.

It meant so much to me. It was such a turbulent time in my life and there was so much uncertainty, Percival said. I was forced to keep trekking.

Percival played football at Princeton and graduated from in 2019 with a bachelors degree in psychology. He continued his studies last fall, enrolling in a two-year post-baccalaureate program at Hofstra. The 24-year-old is on pace to graduate in May 2021 and plans on attending medical school. He will be applying to Hofstra, NYU, Columbia, Cornell, Harvard and Yale.

I would come back home every single week to take care of her, during my time at Princeton. It was really five years of me going back and forth, taking her to doctors and seeing how they cared for her, Percival said. It motivated me to be one of those people that can help someone elses mom one day.

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PETER KERSICH

Thomas Cutinella was known to his teammates as a selfless, hard-working leader. He put himself before others and always thought of those around him first.

Those were some of the qualities that the Shoreham-Wading River football and lacrosse player embodied that helped him win the 2015 Marcus A. Henry Award.

Cutinella, who died Oct. 1, 2014 after an injury he suffered playing football, never got an opportunity to attend the U.S. Military Academy and ultimately serve his country like he had dreamed.

But his legacy lives on.

He was just such a personable, outgoing and upbeat person, Shoreham-Wading River athletic director Mark Passamonte said. I was relatively new to the job but I had felt like I knew him my whole life.

The football field at SWR was renamed in his honor and there is a life-sized bust of Cutinella that was created as part of an Eagle Scout project.

His family has set up the Thomas Cutinella Memorial Foundation, which raises money for scholarships. The Suffolk football coaches association has awarded the Thomas Cutinella Memorial Leadership award every year since 2014 and Section XI implemented the Tommy Tough standards for football in hopes of changes that will protect the integrity of the game, minimize risk and allow for positive growth.

GENE MORRIS

Livingstone Harriott Jr. has always been something of a Renaissance man.

An academic and athletic standout at Central Islip, he won this award two years before his sister did. Now, Harriotts resume is as jam-packed as ever, and hes graduating from Brown University with a degree in economics.

Harriott played four years of football at Brown, and this season caught 27 passes for 464 yards and three touchdowns. Through football, Harriott gave back to the community as his team frequently spent time working with students at the nearby Vartan Gregorian elementary school.

During his freshman and sophomore years, Harriott was part of Athletes in Action, a Christian fellowship group for athletes at Brown. He also participated in student government, serving as the Chair of Academic Affairs this year, which he said allowed him to be a voice for students.

Harriott said he hopes to apply to law school. He has had a handful of internships in the field, including working with the United States Attorneys office out of the Eastern District last summer.

-LAURA AMATO

Kelsi King continues to let her love of science influence those around her. She has completed her junior year at Duke where she is studying neuroscience,

Ive gotten involved in research and the application of neuroscience outside the medical setting, like how can neuroscience be applied to business, King said. And how I can use research to better understand how we make decisions and how that can affect finance and things like that.

Some of Kings work focused on cognition and aging and how that affects motivation and an individuals decision-making skills and peoples everyday choices.

King, who was a captain in field hockey and lacrosse at Baldwin, plays on the Duke club lacrosse team. She also joined a club at Duke that encourages and works with womeninterested in science.

She is undecided about possible medical school or graduate school.

Id like to keep pursuing something that allows me to stay involved in research, King said. But Im really open to wherever that leads me.

OWEN OBRIEN

Its all adding up for Alexandrea Harriott.

Central Islips valedictorian in 2018, Harriott has studied applied mathematics at Harvard University, with a focus on economics as well as global health and health policy.

Harriott also has worked with the Phillips Brooks House Association, a student-run organization. With the group, Harriott participated in Y2Y Harvard Square, which provides a safe environment for young adults experiencing homelessness. Shes helped with first-weekend cleanups, getting elementary and middle schools in the Boston-area ready for the school year, as well as a mentoring program.

Harriott has served as the treasurer of the Harvard Caribbean Club and, next year, will be the clubs vice president. Shes also a member of the Kuumba Singers of Harvard College, which she called one of the greatest things I do on campus.

And this year, Harriottjoined the crew team.

I was like, I really want to get back in shape, I want to join a team again, Harriott said. Its such great energy when youre on a team.

LAURA AMATO

Kenneth Wei, a multi-event track and field state high school champion, is studying bioengineering at MIT.

Theres a saying at MIT that getting an education at MIT is like trying to get a drink of water out of a fire hose, Wei said. Thats definitely true here. Everything just comes at you at once.

Wei was a six-time track and field state champion and a three-time All American in his senior indoor and outdoor seasons. During his time at Mount Sinai, he was senior class president, was named an All-County flautist, and interned in the biology department at Brookhaven National Laboratories in Upton.

Wei runs track at MIT, and this year was named All-New England in hurdles. He also qualified for the NCAA Division III National Championships in the 60-meter hurdles, long jumpand triple jump before the meet was cancelled due to the COVID-19 outbreak.

Its been a lot of fun, Wei said. Ive made a lot of friends and met a lot of people.

JORDAN LAUTERBACH

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Marcus A. Henry Award past winners: Where are they now? - Newsday