All posts by medical

To Better Understand COVID-19, Researchers Review Aging, Immune Response to Viral Infections – University of Michigan Health System News

Information about the new COVID-19 infection is constantly evolving based on what clinicians see firsthand. One constant, so far, is that the older population tends to fare worse than younger folks with this disease.

A team led by Daniel Goldstein, M.D., already studies aging and the influenza viral infection, and took this spring away from their lab to figure out if any of their other research, and other research they regularly read, could be helpful in the fight against COVID-19.

Influenza is of course a different pathogen, but it may give some catalyst for research with the current SARS-CoV2 infection, says Goldstein, of the Michigan Medicine Frankel Cardiovascular Center. Goldstein, with Judy Chen, a doctoral student, and William Kelley, a postdoctoral research fellow, published a new review in the Journal of Immunology.

We believe some of the phenomena that were seeing with the current pandemic are similar to what weve seen in our research with aging, Goldstein says. There seems to be a higher mortality because of dysregulated inflammation more than impaired viral control.

Additionally, increasing activation of neutrophils is reported in the current COVID-19 pandemic, which the authors have reported in their flu models. And how aging affects the immune system prior to infection is the same, and also potentially applicable in understanding the population afflicted by COVID-19, the authors say.

However, there are certainly some unique things about this virus were still learning, Goldstein says.

Paper cited: Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19, Journal of Immunology. DOI:10.4049/jimmunol.2000380

SEE ALSO: Why Are the Elderly More Likely to Catch Flu? Mouse Study Investigates

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To Better Understand COVID-19, Researchers Review Aging, Immune Response to Viral Infections - University of Michigan Health System News

Letter to the editor: Cautious behavior is necessary – Suburbanite

SaturdayJun6,2020at12:01AM

Todays DR front page (June 2) shows young folks who are not masked or socially distanced. Other articles showed adults in three group photos doing no better.

Our other paper, the Wall Street Journal, has a section today, "Values Arent Optional." It poses, "What do we keep from our heritage that still serves us well?" And "Even worse that having poor values is sending a double message of this is good for everyone else, but were special."

The WSJs focus is money management but applies more broadly. It affirms how values inculcated long ago influence who I am as spouse, dad, friend, doctor, community member.

I thought back to the DRs photos.

Ive not driven once in 52-plus years without seatbelt. Not once have I benefited from those seatbelts. But my good fortune doesnt mean that cautious behavior was "unnecessary."

Before dermatology, I was a CDC epidemiologist in its pre-political era. I did an immunology fellowship after residency. Im saddened that thousands have died because our country dismantled preparations put in place to prepare for diseases such as H1N1, MERS, and SARS and Ebola. And that our leaders failed to do what other advanced countries have done to reduce deaths in their populations. But, those horses are out of the barn.

Now, we are beginning to venture out into a minefield with no sensors to protect us. Masks and distancing are the best we can do. But those measures help only if there is shared trust and respect within our community.

Violations of basic virus safety endanger others more than do drivers without seatbelts or motorcyclists without helmets ("kidney donors," in medical lingo). It is like abolishing drunk driving laws and regulation of trucks brakes, then asking me to drive on the interstate.

Our economy needs us to get back into the swing of things as best we can. It hurts businesses and those who need jobs if many of us are held back by the machismo of others. And it hurts our kids if the grown-ups they see dont manifest decency and common sense.

Jay Klemme

Wooster

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Letter to the editor: Cautious behavior is necessary - Suburbanite

Depression May Increase Airway Compromise in Children With Asthma Who Are Overweight/Obese – Pulmonology Advisor

In children with asthma who are overweight or obese, depressive symptoms may enhance airway compromise, according to a study published in the Journal of Allergy and Clinical Immunology Practice.

A total of 250 children with asthma between the ages of 7 and 17 years were included in this study. Patients were classified based on their body mass index (BMI) as having normal weight (mean BMI, 18.5; n=110; mean age, 11.5 years) or being overweight/obese (mean BMI, 27.5; n=140; mean age, 11.2 years). The Child Depression Inventory was used to assess the presence of depression. Among children without depression, 79 had normal weight (71.8%) and 109 were overweight/obese (77.9%). Among children with depression, 31 children had normal weight (28.2%) and 31 were overweight/obese (22.1%).

Pulmonary function was evaluated by measuring forced expiratory volume in 1 second (FEV1), and asthma severity was assessed according to the National Asthma Education and Prevention Program Expert Panel Report 3 criteria. The movie E.T. The Extra-Terrestrial was shown to participants to evoke emotional/stress and arousal. Airway resistance (Rint) was measured before and after film to identify airway function changes associated with emotional states triggered by the viewing. Parasympathetic/vagal and sympathetic reactivities were measured during the movie to assess autonomic nervous system reactivity.

In children who were overweight/obese vs normal weight, symptoms of depression were found to be associated with lower FEV1 at baseline (P =.008). Additionally, higher depression scores predicted greater vagal bias under emotion stress/arousal (P =.009), and greater vagal bias was associated with increased Rint in the overweight/obese group (P =.023).

A limitation of this study was the inclusion of patients who were mostly from minority backgrounds, which may reduce the generalizability of the findings.

Comorbid obesity and depression should be identified by clinicians for children with asthma. Treatment of these risk factors and/or anticholinergic inhaled medication as adjunct therapy may offer benefit in children with asthma, obesity, and depression, concluded the study authors.

Reference

Hsu CY, Lehman HK, Wood BL, et al. Comorbid obesity and depressive symptoms in childhood asthma: A harmful synergy [published online April 15, 2020]. J Allergy Clin Immunol Pract. doi: 10.1016/j.jaip.2020.03.036

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Depression May Increase Airway Compromise in Children With Asthma Who Are Overweight/Obese - Pulmonology Advisor

What Is Immunotherapy? How It Works, What Types of Cancer It Treats – Parade

In a perfect world, our immune system would work seamlesslyable to sense and recognize infectious organisms and foreign invaders (called antigens) and fight off disease with powerful and protective antibodies. But sometimes, it malfunctions.

Enter immunotherapy.

Although immunotherapy is a relatively new therapy, the medical establishment has been working to mobilize the immune system to fight disease for years, says Dale Shepard, M.D., a medical oncologist at Cleveland Clinic. In fact, William B. Coley, M.D. (now called the Father of Immunology) experimented with it back in the late 1800s when he was frustrated with surgerys failure to treat a patient with cancer. Coley injected his patient with bacteriaand it worked. The discoveries of chemotherapy and radiation overshadowed Coleys finding, and it would be years before immunotherapy reemerged as a respected and effective way to treat many cancers.

Also known as biologic therapy or immune-oncology, immunotherapy is a triple-whammy treatment: It trains the immune system to seek out and attack certain cancer cells, it boosts immune cells to eliminate cancer and it boosts the bodys immune response. And, unlike chemotherapy, which is unable to distinguish between healthy cells and cancer cells, this revolutionary treatment spares healthy cells.

Although immunotherapy can be a powerful foe against cancer, it cant treat every single type of cancer (there are more than 100), nor is it for everyone, says Shepard. Though used for more than 20 cancer types, most commonly, we use it for head and neck cancers, melanoma, lymphoma, bladder, kidney and some lung cancers, he says.

Related:Heres the Latest on Skin Cancer Treatment, Including Immunotherapy

One of the most famous people who has benefitted from immunotherapy is former president Jimmy Carter. Diagnosed in 2015 with metastatic melanoma that had spread to his brain and liver, Carter was treated with surgery and radiation and given an immunotherapy drug that had been approved for advanced melanoma by the FDA just the year before.

Carter, then 91 years old, was declared cancer-free just four months after his surgery, radiation and immunotherapy treatments. Experts feel confident that his immune system will continue to protect him against his cancer.

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Given by injection in a doctors office, the immunotherapy drug Carter took is also used for small cell lung cancer, head and neck cancers, Hodgkin lymphoma, advanced stomach cancer and various other types. This year, it was approved to treat inoperable triple-negative breast cancer, for which chemotherapy had been the only treatment option.

Research continues to expand the number of people who can benefit from immunotherapy, and the future looks promising, says Shepard. Immunotherapy has opened up treatment options for a lot of people who didnt have them in the past.

Related:Jimmy Carters Medical Miracle

Scientists are working hard in the fight against COVID-19 (SARS-CoV-2), the greatest global public health crisis many of us have ever witnessed. Vaccines are a form of immunotherapy too, and the race is on to find potential treatments and a vaccine for the virus.

We need to understand the basic mechanisms of how the virus interacts with our immune system, says Thaddeus Stappenbeck, M.D., Ph.D., chair of the Department of Inflammation and Immunity at Cleveland Clinics Lerner Research Institute. The good news is that immunologists from around the world are developing tools to uncover this vital information. The Father of Immunology would be very proud.

Next,Research Is the Reason Im Alive: Lung Cancer Survivors Share Their Heart-Wrenching Cancer Journeys

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What Is Immunotherapy? How It Works, What Types of Cancer It Treats - Parade

AstraZenecas cancer drug shows early signs of promise in treating severe Covid cases – ThePrint

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New Delhi: Calquence, a blood cancer drug manufactured by the British-Swedish pharmaceutical company AstraZeneca, has shown initial positive results in the treatment of severe Covid-19 patients, according to a preliminary study.

Published in the science journal Science Immunology Friday, the study was conducted on 19 Covid patients who were started on a 10-14 day course of calquence, whose generic name is acalabrutinib. Eleven of these patients were on oxygen. Nine of them were discharged.

The oxygenation and clinical status of most patients on supplemental oxygen improved relatively rapidly following acalabrutinib initiation, the study said.

Also read:WHO changes guidelines on masks, says wear them when social distancing not possible

The US-based study was conducted on severe Covid-19 patients between 20 March and 10 April. Of the 19, 11 patients were receiving supplemental oxygen and the remaining eight were on the ventilator.

In the first cohort that was receiving supplemental oxygen, five were on other medication including steroids and/or hydroxychloroquine (HCQ). All eight patients on the ventilator were on concomitant drugs, which included steroid and/or HCQ.

Following the calquence treatment, nine of the 11 patients in the supplemental oxygen cohort were discharged. Of the remaining two in this group, one remained hospitalised and the other died.

In the second cohort that was receiving ventilation, three patients were discharged, one discharged to rehabilitation while the remaining four died.

In all, 12 patients achieved normal oxygenation on room air (2 more that at our formal data cutoff) and none have had a recurrence, the study noted.

So far, research has indicated that mortality among severe Covid-19 patients is caused by excess production of a type of protein known as cytokine by the immune system. In the study on the effectiveness of calquence, researchers found that the drug was successful in suppressing the particular protein the IL-6 protein that causes a cytokine storm.

This happens as a result of the drug targeting the Brutons tyrosine kinase (BTK), an enzyme which plays a role in the excess production of IL-6. In keeping with these findings, blood IL6 levels in Covid-19 patients on our clinical study decreased during acalabrutinib treatment, the study concluded.

According to reports, the results were promising enough for AstraZeneca to launch the second phase of the trial, which will involve 200 patients.

Acalabrutinib, a US Food and Drug Administration-approved drug, is a particular type of kinase inhibitor a substance that blocks a certain enzyme known as kinases. Certain kinases are active in cancerous cells, and blocking them using inhibitors prevents their growth.

The drug is used to treat certain types of cancer including mantle cell lymphoma, small lymphocytic lymphoma and chronic lymphocytic leukemia.

Side effects of this medication, however, could lead to headache, diarrhea, low blood count, fatigue and, in rare cases, irregular heart rhythm (known as arrhythmia).

Also read:Covid patients with high blood pressure face double risk of death, says Chinese study

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AstraZenecas cancer drug shows early signs of promise in treating severe Covid cases - ThePrint

Drug used to treat blood cancers might help reduce COVID-19 severity in patients: Study – Deccan Herald

Scientists have observed that a drug which is already approved to treat several blood cancers, is associated with reduced respiratory distress and a reduction in the overactive immune response in COVID-19 patients, an advance that may lead to a potential therapeutic for novel coronavirus infection.

According to the researchers, including those from the National Cancer Institute in the US, the cancer drug acalabrutinib blocked the protein Bruton tyrosine kinase (BTK) in COVID-19 patients, and provided clinical benefit to a small group of them.

The study, published in the journal Science Immunology, noted that the findings should not be considered clinical advice, and remain to be tested in a randomised, controlled clinical trial.

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The BTK protein, according to the scientists, plays an important role in the immune system, including in macrophages which are immune cells that can cause inflammation by producing proteins known as cytokines.

These proteins, the researchers said, act as chemical messengers that help to stimulate and direct the immune response.

In some patients with severe COVID-19, the study said a large amount of cytokines are released in the body all at once, causing the immune system to damage the function of organs such as the lungs -- a process known as a "cytokine storm."

The current study involved 19 patients with a confirmed COVID-19 diagnosis that required hospitalisation, as well as with low blood-oxygen levels and evidence of inflammation.

According to the scientists, 11 of the 19 patients had been receiving supplemental oxygen for a median of two days, and eight others had been on ventilators for a median of 1.5 days.

The study noted that within one to three days after they began receiving the cancer drug, majority of patients in the supplemental oxygen group experienced a substantial drop in inflammation, and their breathing improved.

It said eight of the 11 patients were able to come off supplemental oxygen, and were discharged from the hospital.

Although the benefit of acalabrutinib was reported to be less dramatic in patients on ventilators, the scientists said four of the eight patients were able to come off the ventilator, two of whom were eventually discharged.

According to the scientists, the ventilator patient group was extremely clinically diverse and included patients who had been on a ventilator for prolonged periods of time and had major organ dysfunction.

Two of the patients in this group died, they said.

An analysis of blood samples from the patients revealed that the levels of interleukin-6 (IL-6), a major cytokine associated with hyperinflammation in severe COVID-19, decreased after treatment with acalabrutinib.

The scientists said counts of lymphocytes, an immune cell type associated with worse outcome in COVID-19 patients, also rapidly improved in most patients.

When the researchers tested blood cells from patients with severe COVID-19, who were not in the study, and compared it with samples from healthy volunteers, they found that the patients with severe COVID-19 had higher activity of the BTK protein and greater production of IL-6.

Based on these findings, they suggested that acalabrutinib may have been effective since its target, BTK, is hyperactive in severe COVID-19 immune cells.

However, in a note of caution, the scientists also mentioned in the study that the most common adverse events associated with long-term acalabrutinib therapy included "low-grade headache, diarrhea, pyrexia and upper respiratory tract infections."

They said the safety profile of acalabrutinib in patients with severe COVID-19 needs to be confirmed in a prospective clinical trial.

"Further correlative studies will be needed to understand the basis for response or resistance to BTK inhibition in patients with such advanced disease," the scientists wrote in the study.

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Drug used to treat blood cancers might help reduce COVID-19 severity in patients: Study - Deccan Herald

Carl Watner: The Tragedy of Political Government | Op-Ed Bitcoin News – Bitcoin News

What is tragic about political government? you might ask. Let us return to that question once we have examined the nature of political government and the State. In order to distinguish between government and other institutions in society we must look at the ways human behavior can be organized and human needs and desires satisfied.

There are only two ways: peacefully or coercively. There are no other alternatives. If people rely on peaceful cooperation, they must necessarily offer products or services for which other people are willing to trade. If people use coercion or fraud, we call it obtaining goods or services under false pretenses, robbery, or larceny. However we label it, the basic contrast remains the same: one relies on voluntaryism or one relies on force.

A stranger knocks at your door and, upon opening it, he requests money He represents the March of Dimes, and is asking for donations to support its activities. Unless you feel generous, you dismiss him. You have no particular obligation to support his cause, and the fact is you have already contributed to other charities, such as the United Way. Unless the stranger is a blatant thief, he leaves. He doesnt deal with you by using force, or its threat, to collect the money he is soliciting.

Compare this to what happens every April 15th in the United States. Granted, most good citizens send in their tax payments to the Internal Revenue Service. The IRS does not need to send out a representative to collect the tax; and if there is any need to do so, he generally neednt carry a gun or make any direct display of force.

Why dont people dismiss the IRS in the same manner as they would the solicitor who is collecting for a private cause? Many would, except they know that there is a big difference between the March of Dimes and the IRS. The March of Dimes organization is a group of private individuals assembled together for the common purpose of overcoming polio, muscular dystrophy, and birth defects. They do not use force, or the threat of force, to accomplish their goals. Should they, we would have no hesitation in calling the March of Dimes, and its solicitation agents, criminal.

The IRS, on the other hand, represents the government, which when all else fails uses force to accomplish its goals. If you do not voluntarily pay your taxes, your property is confiscated, or you are jailed. The amazing thing about our government in the United States is that it rarely has to resort to force. There are tax resisters, but they form a small percentage of the population. Except for these few people, no one calls IRS agents criminals even when they brandish guns, confiscate property, or put people in jail. Despite the fact that they engage in the same type of behavior as the private thief or kidnapper, its seldom that their behavior is called criminal. Why is this so?

Government is the only institution in our civilized society that is able to cover its coercion (and its use of threats) in a shroud of mystique and legitimacy There are other individuals and groups in society that use force: individual criminals (the lone burglar, rapist, etc.), and groups of criminals (the Mafia or gangs of thieves, etc.). But none of these claim their activities are proper and useful. Government is the only one of these coercive groups that claims its use of force is legitimate and necessary to everybodys wellbeing.

Government is the institutionalization of conquest over the people and property in a certain territory The stated purpose of government is protection. In reality it is exploitation: to extract resources which otherwise would not be voluntarily handed over to the governors. Governments excel in the use of force and threat the political means of survival by combining military conquest and ideology. Though throughout history, governments have been of many different types, their reason for being and modus operandi have never changed. Governing requires that those who govern authorize or commit criminal acts, actions which, if used by any but the agents of the government, would be deemed criminal.

Governments seek the voluntary obedience of their populace. The continual use of physical force is not only expensive, but often of uncertain results. If the governors can get the governed to accept their conquest as being consistent with widely accepted norms and standards, there is little need to use raw force to continually compel submission. The primary tools which governments use to establish their legitimacy are:

The truth of the matter is that governments use every means at their command to insure their control over society. Other methods include support of special interest groups with legislation and subsidies, celebration of national holidays, frequent elections, use of the secret ballot, sustaining foreign enemies to help maintain internal control, and the full panoply of patriotism.

The main tragedy of political government is that few people realize it is an immoral and impractical institution. Nor do they realize that the power of any government is dependent on the cooperation of the people it governs, and that government power varies inversely with the noncooperation of the people. They have been conditioned to accept government as a natural part of their environment. After being raised in a culture in which politics is the norm, and after attending years of public school and being taught that political government is a necessary component of society, most people place government in the same category as the weather something they complain about, but cant change. As people accept the structural trap called politics, they fail to realize that their actions support and undergird the State. Their demand for government services from Social Security benefits to police protection is what fuels the State.

Most people are capable of high values and responsible behavior, but once they enter the seductive garden of politics, they no longer notice that its wonders cannot be reconciled with individual responsibility and their own personal moral values of honesty and hard work. It is not usually apparent that what they are doing or supporting is vicious and would not pass the test of ordinary decency. So long as the criminality is veiled by the political process, most people accept it because they do not see that it conflicts with their basic values.

The main tragedy of political government is not only that the voters are the ones pointing the gun, but, most importantly, that the indecency of this act is concealed from them by the political process. It is the concealment that is the tragedy. The concealment is not the result of some conspiracy by some distant elite: it is inherent in the political process.

Perhaps the tragedy can be made more plain. Look at the daily news. At least half of every days news consists of accounts of one pressure group or another noisily appealing to the government for greater support of its special agenda. The tragedy is that the people making the demands do not perceive that its their own neighbors from whom they are stealing and sacrificing in order to support their special programs.

The political process -purposefully- is an impersonal one. The secret ballot and the use of majority vote obscure the fact that it is the struggling family next door or the bachelor down the street who are being threatened at gunpoint if they do not fill the governments coffers or follow its mandates. The resources for every government program come from hundreds of millions of people across the United States most of them personally unknown to those who campaign for these programs. Few people would directly confront their neighbors with such demands (Your money or your life!), but the structure of politics permits this to be done anonymously, and allows the supporters and perpetrators to conceal even from themselves the evil nature of what they are doing. Such is the tragedy of political government.

What do you think about Carl Watners essay? Let us know what you think about this subject in the comments below.

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Carl Watner: The Tragedy of Political Government | Op-Ed Bitcoin News - Bitcoin News

Technology Can Help Organizations Reduce Racism, But Will It? – Forbes

Ironically, the same innovations we tend to regard as creepy (e.g., AI, algorithms, and Big Data) may help leaders make their workplace more inclusive. But there are reasons to be skeptical.

Racism in technology concept.

I dont consider myself a techno-enthusiast, and Im definitely not optimistic by nature. So, NO, this isnt another overhyped post on how AI will save the world, or how Big Data (does anyone still use the term?) will make our world better by eliminating racism from society. Sadly, the only way to achieve that would be to eliminate humans, too. Indeed, if we were fully replaced by algorithms, racism would go extinct, much like if we replaced all human drivers with self-driving cars, traffic accidents would be rare - they would still happen, primarily due the unpredictability of human pedestrians.

Leaving aside these unlikely scenarios, and you can decide for yourself if they are more utopian or dystopian, it may be useful to understand a few of the more realistic ways in which technology could, if we truly wanted, help us keep racism in check, at work and beyond. After all, we have entered an age in which leaders willingness to reduce racism appears to have surpassed their ability to do so. So, if we want to move from condemnation to intervention, from criticism to solutions, we have to leverage every resource we have, and be open to new solutions, not least since traditional interventions have enjoyed limited success. Just look at the conclusion of a comprehensive academic reviews on the subject: Of the hundreds of studies we examine, a small fraction speak convincingly to the questions of whether, why, and under what conditions a given type of intervention works. We conclude that the causal effects of many widespread prejudice-reduction interventions, such as workplace diversity training and media campaigns, remain unknown.

There are at least four obvious ways in which technology, especially data-driven approaches to managing employees, could help us reduce workplace racism:

(1) Analyzing e-mail and messaging metadata (the context and social networks of communications): Without intruding in peoples privacy or reading what people say in their work-related communications, which in itself would not be illegal, algorithms can be trained to map the social networks in a team or organization, identifying individuals who are excluded from social interactions. Overlaying that data to demographic information on diversity (race or otherwise), could help organizations model inclusion digitally, using passive and non-invasive measures. Imagine a leader or HR professional, like a Chief Diversity Officer, who can access group-level data to assess whether race (or being part of any minority group or protected class) is statistically related to being left out, ignored, or ostracized from the team or organizational network. This granular level of evidence is likely to reveal exclusion where self-reports do not. People are not always aware of their unfair treatment of others, rationalizing their own actions to construct a benevolent self-concept, which is why the vast majority of people see themselves as nice, even when others dont. And when they are, they are pretty good at disguising it, which is why the number of people who answer yes to the question are you a racist?, is far lower than the number of actual racists.

(2) Analyzing the actual content of communications (Natural Language Processing and red flags): Without getting bosses, or any human, to spend any time snooping on employees communications, AI could certainly be trained to reliably monitor the words people use when they interact in any digital medium. Of course, we did not need AI to deter people from misbehaving in traceable or recorded communications, and cautious employees have always found ways to keep offensive comments (including prejudiced and racist jokes) offline. But with an unprecedented level of work exchanges now happening online or in virtual environments, only AI could keep an eye on all the possible toxic, antisocial, or counterproductive comments. With rapid advances in Natural Language Processing, software that translates patterns of word usage into a psychological profile of the individual, including their potential level of prejudice, anger, and aggression, it is easier than ever for organizations to detect and sanction racist behavior. What happens offline tends to stay offline, but what happens online is recorded for posterity. Note the application of this technology to reducing racism could be twofold: you can check for actual offenses, which is what humans would do in the case of reported behaviors, or if they are actually spending their time reading everything people say; or you could check for potential, which means identifying signals that predispose or increase someones probability to misbehave in the future. The latter is ethically more questionable, but also enables prevention; whereas the former is mostly helpful for sanctioning behaviors after they happened.

(3) Mining the digital footprint of external job candidates, particularly for leadership roles (reducing selection bias): One of the best ways to reduce racism is to avoid hiring racist employees, particularly to be in charge. An inclusive culture is best harnessed top-down, with teams and organizations that are led by ethical, open-minded, altruistic, and compassionate individuals who show uncompromising commitment to equality and fairness, practice what they preach, and put their money where their mouth is. Throughout most of our human history, we lived in small groups where everybody knew each other well, and our models for understanding and predicting others were bullet-proof: if you systematically misbehaved, you just ended up with a terrible reputation. Fast forward thousands of years, to the typical demands of modern work, where we are forced to make high-stakes decisions about hiring, promoting, trusting, and following others who we barely know. Such are the complexities and ambiguities of work today that we have no way to know whether the person we have in front of us is truly the person we think we see. We do know that you cannot judge a book by its cover, so the only way to make seemingly logical evaluations of others with the rather limited information we have on them - for example, during a one-off job interview, is to rely heavily on our intuition, which is how we end up making prejudiced and racist decisions in the first place, even when we try to avoid it or persuade ourselves that that isnt the case.

Imagine, instead, if we could access a candidates entire online footprint, consisting of everything they have done online in the past. The process would not be manual, of course, but algorithms could be trained to translate peoples digital history into a quantitative estimate of their open-mindedness, tolerance, authoritarianism, and empathy, etc. In some instances, you wouldnt even need algorithms to detect whether someone could have a prejudiced profile, because their behaviors would just signal racism; as when human recruiters run a google search on a potential CEO candidate to gauge their reputation and assess fit. They may not be explicitly looking at indicators of prejudice, but may still want to exclude candidates, or at least one would hope, who dont seem to have a strong reputation for integrity or ethics. As one would expect, there is a booming business for online reputation management, but these digital spin doctors are focused on helping you fool human assessors rather than machine-learning algorithms. And while prejudiced individuals may always find a way to fool both humans and computers, academic research suggests that if a well-trained AI were to access our complete digital footprint - everything from our Uber ratings to our Netflix and Hulu choices, our Facebook Likes, and of course our Twitter and Whatsapp exchanges - it would be able to predict with great accuracy whether we are likely to display any kind of prejudice or discrimination at work and beyond, and with what frequency. This could and should be deployed in an ethical way, asking candidates to opt in and put their data to the test. In fact, it may even be useful developmental feedback for them to find out whether they resemble more or less prejudiced individuals, which the algorithm could report.

(4) Exposing bias in performance ratings (eliminating the politics and nepotism in promotions and performance management systems): The most pervasive form of bias and discrimination people suffer at work, and one of the hardest to detect, is being unfairly evaluated and rated for their performance, whether consciously or not. This bias occurs even in well-meaning organizations, including ethical companies with mature diversity and inclusion policies, and meritocratic talent management intentions. Interestingly, this is an area where AI has attracted a great deal of popular criticism. For instance, when companies attempt to train AI to predict whether an employee is likely to be promoted, or algorithms are used to rank order internal candidates for potential, the likely result is that certain profiles, such as middle-aged White male engineers, over-index, while others, such as Black, Latino, or female, are underrepresented. However, in these examples, the problem is neither the algorithms nor the data scientists who develop them. If you train algorithms to predict an outcome that is itself influenced by systemic bias or prejudice, it will not just reproduce human bias, but also augment it. In other words, middle-aged White male engineers got promoted before AI was trained to reveal this, and they will continue to get promoted even if AI is not used.

Unlike humans, computers dont really care about your race, gender, or religion: they dont have a fragile self-esteem they need to boost by bringing other people down, and they dont need to bond with other computers by stigmatizing certain classes or groups of humans (or computers). One thing they can do, however, and usually rather well, is to imitate the prejudiced preferences of humans. And yet, they can also be trained to not imitate them. Artificial intelligence may never match the breadth and scope of human intelligence, but it can certainly avoid replicating the vast collection of biases encapsulated in human stupidity.

If organizations are able to measure employees job performance objectively, then AI will not only predict it better than humans, it will also identify any distortion or interference introduced by bias. For instance, an Uber driver can be judged on the basis of (a) how many trips she makes, (b) how much money she brings in, (c) how many car accidents she has, and (d) what customer ratings she gets, all relative to other drivers working in the same location, and all done through AI. If two drivers with identical performance scores on (a), (b), and (c) differed significantly on (d), then a simple analysis would suffice to reveal whether the drivers demographic background - e.g., white vs. black - inflated or depressed their scores on (d). So, if businesses, and particularly managers, were able to quantify output (what an employee actually contributes to the team and organization), and there was a formula to predict what someone is likely to produce, then algorithms wont just be better than humans at applying this formula, they will also be better than humans at ignoring the wide range of extraneous variables (including race) that distract human managers from focusing on that formula. In judgments of talent, humans are not great at paying attention to the stuff that matters, or ignoring the stuff that doesnt.

OK, so if all this sounds that simple, then whats stopping organizations from adopting these measures? After all, technology keeps getting cheaper and cheaper, they are sitting on a growing volume of data (just think about the last 3-months of videoconferencing data), and theres no shortage of data scientists who can help with this.

Three things, which do warrant a reasonable degree of skepticism, or at least a non-trivial amount of realistic pessimism.

The first is the double standards that make most people adopt the highest moral principles when they judge AI (or any new tech), while being much more lenient, and morally relaxed, when they judge humans. No technology will ever be perfect in predicting or detecting any form of human behavior, whether good or evil. Thats not the point. The point is that technology could be more accurate - and less biased - than humans, or at least that it could help humans be less biased. So, if we are comfortable understanding that even the latest, most advanced, tech will get things wrong, then lets focus on what really matters, which is whether that tech can at least minimize human bias and discrimination, even by 1%. Given humanitys historical record here, it is safe to say that the bar is pretty low, and that even rudimentary technologies may represent a hopeful improvement over the status-quo: pervasive prejudice and ubiquitous bias, courtesy of the human mind.

The second is that diagnosing or detecting the problem is necessary, but not sufficient, to fix it. So, suppose that some of the emerging technologies mentioned here reveal racism, or any other form of discrimination in a team or organization; what next then? Will leaders genuinely act on these data to sanction it, especially if it creates conflict or leads to negative short-term outcomes, particularly for themselves? Will they change the rules, the system, and those who oversee it, in order to improve progress and create a fairer, more meritocratic system? In general, people have little incentive to change the status quo when they are part of it. How comfortable will they be acknowledging that the status quo was rigged? Clearly, many leaders may prefer to avoid any new technology if it has the potential to expose the hitherto invisible toxic forces that govern the power dynamics in their teams and organizations. And AI, not just in HR but in any other area of application, is like a powerful X-ray machine that can reveal unwanted forces and socially undesirable phenomena: like opening a can of worms. It is always painful to make the implicit explicit, and the foundational grammar of any culture - both in companies and societies - is largely made of silent and subliminal rules, which makes them resistant to change. One of the disadvantages of living in a liberal world is that domination is rarely explicitly asserted, but hidden under the pretext of equality.

The third is that employers must be realistic about what can probably be achieved. Discussions on race and inclusion often focus on bias and prejudice, but it may be unrealistic to change the way people think, especially if they are part of a non-conformist minority, and how ethical would this be anyway? Crucially, peoples attitudes or beliefs are surprisingly weak as predictors of actual behavior. This means that discrimination - the behavioral side of prejudice - often happens in the absence of strong corresponding beliefs (conscious or not). Likewise, most of the people who are prejudiced - and hold derogatory attitudes towards individuals because of their race, gender, etc. - will rarely engage in overt discriminatory behavior. In short, we should focus less on changing peoples views, and more on ensuring that they behave in respectful and civil ways. Containing the expressed and public manifestations of racism at scale may be the best leaders can hope for, for they will not be able to change the way people think and feel.

Finally, we should not forget that not all leaders will be interested in reducing racism in their organizations, particularly if the process is slow and painful, and the ROI isnt clear. Such leaders may not just neglect the potential value of new technologies for reducing workplace discrimination, but use it to perpetuate existing practices, amplifying bias and prejudice. In the long run, every decision leaders make will shape the culture of their organizations, and employees and customers will gravitate towards those cultures and brands that best represent their own values and principles.

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Technology Can Help Organizations Reduce Racism, But Will It? - Forbes

COVID-19, smell and taste how is COVID-19 different from other respiratory diseases? – Kiowa County Press

A health worker carries out an olfactory test to monitor smell loss to a resident 65 km from Buenos Aires city, on May 24, 2020, amid the COVID-19 coronavirus pandemic. ALEJANDRO PAGNI/AFP via Getty Images

John E Hayes, Pennsylvania State University and Valentina Parma, Temple University

In March 2020, Google searches for phrases like "can't taste food" or "why can't I smell" spiked around the world, particularly in areas where COVID-19 hit hardest. Still, many of us have experienced a temporary change in the flavor of our food with a common cold or the flu (influenza). So, is COVID-19 - the disease caused by the SARS-CoV-2 virus - somehow special in the way it affects smell and taste?

We are researchers who study the relationships between human behavior and the sensations people experience from chemicals in daily life. Upon learning that COVID-19 might differentially affect taste and smell, we thought our expertise might be relevant, so we got to work.

When people "taste" food, they are experiencing input from three different sensory systems that are knitted together to form a singular unified sensation. Strictly speaking, taste describes the five qualities we sense on the tongue, including sweet, salty, bitter, sour and savory/umami. Savory, also known as umami, refers to the meatiness of broth, cheese, fish sauce, or a sundried tomato.

Taste involves more sensory systems than just your mouth. Tom Merton / Getty Images

Other sensations from food occur via our sense of smell, even though we experience them in the mouth. Volatile chemicals are released when we chew. These chemicals travel through the back of the throat to reach smell receptors found at the top of the nasal cavity, right behind the point where your eyeglasses rest on your nose.

The third sensory system involved in food flavor involves touch and temperature nerves that can also be activated by chemicals. This is known as chemesthesis. In the mouth, these sensations include the burn of chili peppers, the cooling of mouthwash or mints, the tingle of carbonation, or the vibrating buzz of Sichuan peppers. Together, these three chemosensory systems - taste, smell and chemesthesis - work to define our perceptual experiences from food.

Loss of smell is common with many viruses, including rhinoviruses, influenza, parainfluenza and coronaviruses, and it is normally attributed to nasal inflammation that restricts airflow.

If your nose is blocked, it is not surprising you are not able to smell much. Typically, the other two systems - taste and oral chemesthesis - are not affected, as a blocked nose does not alter our ability to taste sugar as sweet or feel the burn from a chili pepper. With time, most patients recover their senses of smell, but occasionally some do not. Causes vary, but in some individuals, inflammation from a viral illness appears to permanently damage key structures located around the smell receptors.

Since early spring 2020, firsthand reports have indicated that the SARS-CoV-2 virus, the novel coronavirus that causes COVID-19, might affect the mouth and nose more severely than the common cold or the flu. Not only were the reports of loss more frequent, but they also differed from what is normally seen.

One British surgeon with COVID-19 posted a video to Twitter showing that he had lost the ability to feel the burn of chilies. Others, like Penn State undergraduate Caela Camazine, reported losing their sense of smell and taste completely without any nasal congestion.

Dr. Whitehead has lost his ability to taste the burn of chili peppers. Screen grab

Based on the spike in Google searches, and these atypical accounts of chemosensory loss, more than 600 researchers, clinicians and patient advocates from 60 countries formed the Global Consortium for Chemosensory Research.

The Global Consortium for Chemosensory Research launched a global survey in 32 different languages to better understand what COVID-19 patients are experiencing. Initial results from our survey support the idea that COVID-19 related losses are not limited to smell, as many patients also report disruption of taste and chemesthesis.

Our understanding of how the SARS-CoV-2 virus can affect multiple sensory systems is still quite limited, but is advancing daily. Initial work suggests that smell disturbances in COVID-19 patients are caused by the disruption of cells that support olfactory neurons. In our noses, we have nerve cells called olfactory sensory neurons, which are covered with odor receptors tuned for certain volatile chemicals. When a chemical binds an odor receptor, the olfactory sensory neuron fires a signal to the brain which we perceive as a smell. Notably, it does not appear that the virus targets olfactory sensory neurons directly.

Instead, the virus seems to target specialized supporting cells that cradle the olfactory sensory neurons. These support cells are covered with a different receptor, the ACE2 receptor, which acts as an entry point for the virus. In contrast, the way SARS-CoV-2 might directly affect taste and chemesthesis remains unknown.

We just don't know yet whether COVID-19 patients will recover their sense of smell, taste and chemesthesis. Many patients have reported recovering completely within two or three weeks, while others report their sensory loss lasts for many weeks. To connect with other individuals who are experiencing smell and taste loss related to COVID-19, consider reaching out to organizations advocating on behalf of those who suffer from smell and taste loss, such as AbScent and FifthSense.

Because more data are needed, we are asking for your help in our research. If you know anyone who is (or recently has been) coughing and sniffling, invite them to complete the Global Consortium for Chemosensory Research survey, which takes about 10 minutes.

We want anyone who has had any upper respiratory illness (COVID-19 or not) recently so we can compare individuals with COVID-19 to individuals with the flu or the common cold. By volunteering for our study, or by spreading the word on this research study, you can contribute to better understand how COVID-19 is special in its ability to affect smell, taste and chemesthesis.

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John E Hayes, Associate Professor of Food Science, Pennsylvania State University and Valentina Parma, Research Assistant Professor, Temple University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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COVID-19, smell and taste how is COVID-19 different from other respiratory diseases? - Kiowa County Press

Why meat is no longer essential in the vegan-friendly Bay Area – San Francisco Chronicle

Heres something that seems to sum up the complicated relationship many of us have with animals: The San Francisco SPCA, a no-kill shelter, is an essential service, as are all animal shelters in the state. Also considered an essential service is the states meatpacking industry, whose sole purpose is to slaughter and butcher animals.

One animal is your friend and the other animal is your food. We can keep this equation very simple by keeping our pets (mostly cats and dogs) in the friend category and putting everything else in the food category. But few things are that simple during this pandemic as the Bay Area negotiates what is essential and what isnt, whats safe and what isnt. And the larger question of who bears the brunt of the coronavirus and who doesnt.

My husband and I have been vegetarians for decades. During E. coli outbreaks (the bacteria is less prevalent in produce although there is still a risk), the scares of mad cow disease (2005), swine flu (2009), bird flu (2015) and various other diseases, Ive always thought, Im so glad Im a vegetarian. Not in some holier than thou way, but in a one less thing to worry about way.

I have written previously about how I became a vegetarian. I could cite statistics showing the benefits of a vegetarian or vegan diet on everything from health to climate change. And certainly those things are important. But even if I take all that away, Im left with this: Alice conversing with a white rabbit in Alice in Wonderland. Mr. Toads glorious adventure in The Wind in the Willows. Or Peter Rabbit escaping Mr. McGregors garden in The Tale of Peter Rabbit. To put it another way: I cant seem to keep just cats and dogs in the friend category. Other animals hop in there, too rabbits, frogs, ducks. Animals simply are not food to me.

I know the animals in those books are an authors invention and perhaps more a commentary on human behavior than animal. But I also know there are people who refuse to acknowledge that animals can express emotions no joy or jealousy. Just try holding onto that belief the next time your dog sees you reach for the leash or the food bowl. Or the next time you spend time petting a friends dog while ignoring your own.

Everyone charts their own course to the dinner table, and for many that course seems to have gotten easier (lots of food and lots of ways to get it) and thornier (the footprint and economics of factory farming, which Merriam Webster defines as: a farm on which large numbers of livestock are raised indoors in conditions intended to maximize production at minimal cost).

A 2018 Gallup poll found 5% of U.S. adults call themselves vegetarian. Not a huge number, but showing signs of growing. Even before the novel coronavirus, plant-based foods were having a banner year with the popularity of Impossible Foods, Beyond Meat and the partnerships of Big Meat with plant-based or cultured meat companies. Retail sales of plant-based foods in 2019 reached $5 billion, according to the Good Food Institute, which supports companies focused on plant-based products. In 2019, People for the Ethical Treatment of Animals named San Francisco the No. 1 vegan-friendly city in the U.S. Thats no surprise to anyone who lives here; what did come as a surprise was Nashville at No. 8 and Tulsa, Okla., at No. 10.

In mid-March, when pandemic panic-buying made flour and yeast disappear, retail plant-based food sales surged, according to the Plant Based Foods Association. And its no wonder. The coronavirus has put a spotlight on essential slaughterhouses and their essential workers across the nation, and its a grim picture: workers shoulder to shoulder on production lines, and hot spots of COVID-19 contagion at plants throughout the country. In Vernon (Los Angeles County), workers at the Farmer John plant called for its shutdown last week after more than 150 employees had tested positive for the virus. Whos essential, and who bears the brunt? In a recent opinion piece, The End of Meat Is Here in the New York Times, author Jonathan Safran Foer takes on these issues of the meat industry.

Live-animal markets face similar scrutiny and present an equally hellish picture. Such markets in Wuhan, China, of course, have been cited in one theory of how the virus spread from bats to another animal to humans. But again, the equation is not quite that simple. An April story by Chronicle reporter Kurtis Alexander reported on a study by UC Davis researchers further connecting human intrusion into animal habitats and mutating viruses. Alexander quoted Chris K. Johnson, professor of epidemiology at the UC Davis School of Veterinary Medicine and lead author of the study: Viruses dont cross over the species boundary very easily. The spillover from animals to humans is the direct result of our actions. Its happening all over the world, and has for decades, as we modify the landscape in major ways.

Just last week, a bill that would ban live-animal markets in California passed its first committee hearing. The bill, SB1175, by state Sen. Henry Stern (D-Malibu), would ban imports and sales of live wild animals, such as turtles, bullfrogs and nonpoultry birds, at live markets.

Does being a vegetarian or vegan make any of this go away? Does it help meat-packers trying to pay their bills avoid a deadly virus? Or help Mr. Toad, who apparently is not joyriding around the English countryside in a waistcoat, and is not even sitting in his natural and shrinking habitat, but is crammed into a cage to become our dinner? I dont know.

But being a vegetarian helps me sleep a little better at night, curled up with my husband and my dog.

Bernadette Fay is a San Francisco Chronicle editor. Email: Bfay@sfchronicle.com

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Why meat is no longer essential in the vegan-friendly Bay Area - San Francisco Chronicle