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AstraZeneca : New analyses from Breztri Aerosphere Phase III ETHOS trial to be presented at the European Respiratory Society International Congress…

* Breztri Aerosphere reduced rate of COPD exacerbations across all seasons compared with Bevespi Aerosphere

* AstraZeneca to present 60 abstracts from inhaled and biologics portfolio and pipeline at the ERS Congress

A post-hoc analysis of the Phase III ETHOS trial showed a consistent benefit of Breztri Aerosphere (budesonide/glycopyrronium/formoterol fumarate) in reducing the rate of moderate or severe chronic obstructive pulmonary disease (COPD) exacerbations across all seasons compared with Bevespi Aerosphere (glycopyrronium/formoterol fumarate) in patients with moderate to very severe disease.1

These data are among 60 AstraZeneca abstracts accepted for presentation, including 10 oral presentations, at the European Respiratory Society (ERS) International Virtual Congress 2020, between 7-9 September.

Gary Ferguson, Clinical Professor of Medicine at Michigan State University, Director of the Pulmonary Research Institute of Southeast Michigan, Farmington Hills, Michigan, US and Investigator in the ETHOS trial, said: "Treating patients with chronic obstructive pulmonary disease can be challenging in the winter as they experience more frequent and more severe exacerbations, contributing to increased morbidity and mortality. Results from the ETHOS trial should give clinicians confidence that they can reduce moderate or severe exacerbations, even during winter when respiratory diseases can put additional strain on healthcare systems."

Ruud Dobber, Executive Vice President, BioPharmaceuticals Business Unit, said: "These additional data from the Phase IIIETHOS trial are important in supporting clinicians' understanding of the robust clinical profile of Breztri Aerosphere, which has been approved in the US, China and Japan and is under regulatory review in the EU. With 60 company abstracts accepted for presentation at ERS, there is a wealth of data across AstraZeneca's inhaled combinations and biologic medicines, which demonstrates our commitment to advancing clinical practice in respiratory disease."

AstraZeneca abstracts to be presented at the ERS International Congress 2020 include:

Breztri Aerosphere

Seasonal variation in COPD exacerbation rates: budesonide/glycopyrronium/formoterol metered dose inhaler (BGF MDI) at two ICS dose levels in the ETHOS trial (Oral presentation: Abstract OA5238, Wednesday 09 September 16:50-17:50 CEST)

Exacerbation benefit by blood eosinophil counts with budesonide/glycopyrronium/formoterol metered dose inhaler (BGF MDI) at two ICS dose levels in the ETHOS trial: a subgroup analysis (E-poster session: Abstract PA984, Monday 24 August)

Symbicort Turbuhaler (budesonide/formoterol)

LATE BREAKER: Reimbursement for asthma care is a universal barrier to achieving asthma symptom control: The SABINA III study (E-poster session: Abstract PA2665, Monday 24 August)

LATE BREAKER: Short-Acting ?2-Agonist Use in Asthma in Western Societies (E-poster session: Abstract PA2629, Monday 24 August)

Efficacy of as-needed budesonide/formoterol in mild asthma: pooled analysis of SYGMA 1 and 2 (E-poster session: Abstract PA2275, Monday 24 August)

Fasenra (benralizumab)

Real-world treatment patterns of benralizumab therapy for patients with severe asthma. (Oral presentation: Abstract OA4646, Tuesday 08 September 15:40-16:40 CEST)

LATE BREAKER: Benralizumab in severe asthma: preliminary results from the Italian ANANKE study (E-poster session: Abstract PA2609, Monday 24 August)

Tezepelumab

Efficacy of tezepelumab in patients with low and high bronchodilator reversibility in PATHWAY (E-poster session: Abstract PA2269, Monday 24 August)

Early science

Profiling the impact of two JAK inhibitors (AZD0449 & AZD4604) in a pre-clinical model of allergic asthma (E-poster session: Abstract PA3302, Monday 24 August)

COPD

COPD is a progressive disease which can cause obstruction of airflow in the lungs resulting in debilitating bouts of breathlessness.2 It affects an estimated 384 million people3 and is the third leading cause of death globally.4 Improving lung function, reducing exacerbations and managing daily symptoms such as breathlessness are important treatment goals in the management of COPD.2 A single COPD exacerbation can have a negative impact on lung function5, quality of life6 and increase the risk of hospitalisation.7 Additionally, even one COPD exacerbation that results in hospitalisation, increases the risk of death.8,9

Patients with COPD experience an increase in incidence of exacerbations and severe exacerbations during the winter.10,11 Studies have also shown higher rates of COPD hospital admissions and more respiratory-related deaths in winter compared with summer months.10-13

ETHOS

ETHOS is a randomised, double-blind, multi-centre, parallel-group, 52-week trial to assess the efficacy and safety of Breztri Aerosphere in symptomatic patients with moderate to very severe COPD and a history of exacerbation(s) in the previous year. The primary endpoint was the rate of moderate or severe exacerbations. Results were published in the New England Journal of Medicine.14

Breztri Aerosphere

Breztri Aerosphere (budesonide/glycopyrrolate/formoterol fumarate) is a single-inhaler, fixed dose triple-combination of budesonide, an inhaled corticosteroid (ICS), with glycopyrrolate, a long-acting muscarinic antagonist (LAMA), and formoterol fumarate, a long-acting beta2-agonist (LABA), delivered in a pressurised metered-dose inhaler.

AstraZeneca in Respiratory & Immunology

Respiratory & Immunology is one of AstraZeneca's three therapy areas and is a key growth driver for the Company.

Building on a 50-year heritage, AstraZeneca is an established leader in respiratory care, across inhaled and biologic medicines. AstraZeneca aims to transform the treatment of asthma and COPD by eliminating preventable asthma attacks across all severities and removing COPD as a leading cause of death through earlier biology-led treatment. The Company's early respiratory research is focused on emerging science involving immune mechanisms, lung damage and abnormal cell-repair processes in disease and neuronal dysfunction.

With common pathways and underlying disease drivers across respiratory and immunology, AstraZeneca is following the science from chronic lung diseases to immunology-driven disease areas. The Company's growing presence in immunology is focused on five mid- to late-stage franchises with multi-disease potential in rheumatology (including systemic lupus erythematosus), dermatology, gastroenterology, and systemic eosinophilic-driven diseases. AstraZeneca's ambition in immunology is to achieve disease control and ultimately clinical remission in targeted immune-driven diseases.

AstraZeneca

AstraZeneca (LSE/STO/NYSE: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas - Oncology, Cardiovascular, Renal and Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Twitter @AstraZeneca.

Contacts

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References

1. Ferguson GT, Rabe KF, Martinez FJ, et al. Seasonal variation in COPD exacerbation rates: budesonide/glycopyrronium/formoterol metered dose inhaler (BGF MDI) at two ICS dose levels in the ETHOS trial. Abstract OA5238 [Oral Presentation]. Presented at the European Respiratory Society International Virtual Congress 2020 (7th-9th September).

2. GOLD. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020. [Online]. Available at: http://goldcopd.org. [Last accessed: September 2020].

3. Adeloye D, Chua S, Lee C, et al. Global Health Epidemiology Reference Group (GHERG). Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J Glob Health. 2015; 5 (2): 020415.

4. Quaderi SA, Hurst JR. The unmet global burden of COPD. Glob Health Epidemiol Genom. 2018; 3: e4. Published 2018 Apr 6. doi:10.1017/gheg.2018.1.

5. Halpin DMG, Decramer M, Celli BR, et al. Effect of a single exacerbation on decline in lung function in COPD. Respiratory Medicine 2017; 128: 85-91.

6. Roche N, Wedzicha JA, Patalano F, et al. COPD exacerbations significantly impact quality of life as measured by SGRQ-C total score: results from the FLAME study. Eur Resp J. 2017; 50 (Suppl 61): OA1487.

7. Rothnie KJ, Mllerov H, Smeeth L, Quint JK. Natural History of Chronic Obstructive Pulmonary Disease Exacerbations in a General Practice-based Population with Chronic Obstructive Pulmonary Disease. Am Jour of Resp Crit Care Med. 2018; 198 (4): 464-471.

8. Ho TW, Tsai YJ, Ruan SY, et al. In-Hospital and One-Year Mortality and Their Predictors in Patients Hospitalized for First-Ever Chronic Obstructive Pulmonary Disease Exacerbations: A Nationwide Population-Based Study. PLOS ONE. 2014; 9 (12): e114866.

9. Suissa S, Dell'Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax. 2012; 67 (11): 957-63.

10. Jenkins CR, Celli B, Anderson JA, et al. Seasonality and determinants of moderate and severe COPD exacerbations in the TORCH study. Eur Respir J 2012; 39: 38-45.

11. Wise RA, Calverley PMA, Carter K et al. Seasonal variations in exacerbations and deaths in patients with COPD during the TIOSPIR trial. Int J Chron Obstruct Pulmon Dis. 2018;13:605-616.

12. Donaldson GC, Wedzicha JA. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2014; 9: 1101-1110.

13. Chakraborti A, Ramanathan R. Alunilkummannil J. Seasonal variations in outcomes and costs for COPD. Chest 2019; 156 (4) Suppl: A1164.

14. Rabe KF, Martinez FJ, Ferguson GT, et al. Inhaled Triple Therapy at Two Glucocorticoid Doses in Moderate-to-Very Severe COPD. N Engl J Med 2020; 383:35-48.

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AstraZeneca : New analyses from Breztri Aerosphere Phase III ETHOS trial to be presented at the European Respiratory Society International Congress...

Hill Named COO of Southern Administrative (Movers & Shakers) – Arkansas Business Online

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Tim Hill of Southern Administrative Services Tim Hill became the chief operating officer of Southern Administrative Services on Aug. 1. SAS uses the Green House Cottage model of nursing home care. In Hills new role he will be responsible for all aspects of elder care operations, quality and safety programs, census development and talent management.

We will look for every opportunity to create a system where we share best practices among client facilities and leverage our position in the market, Hill said in a press release.

Hill has more than 27 years of health care finance and operational management experience. He had served as COO of the University of Arkansas for Medical Sciences Health System since 2017, after fulfilling several roles there since 2011. Over the years, he has had several senior positions for a number of health care organizations, including CEO of Arkansas Heart Hospital in Little Rock and North Arkansas Regional Medical Center in Harrison. The Arkansas Hospital Association named him Administrator of the Year in 1996, when he was running Southwest Hospital in Little Rock.

Hill earned a bachelors degree in business, finance and accounting from St. Cloud State University in Minnesota.

Dr. Erica Horta of UAMS in Little Rock Dr. Erica Horta has been hired as a neuro-immunologist at the University of Arkansas for Medical Sciences in Little Rock.

Horta specializes in multiple sclerosis and brain and spine tumors. She also serves as an assistant professor in the department of neurology in the UAMS College of Medicine.

Horta earned her medical degree and completed a residency and a clinical fellowship at the University of Sao Paulo in Brazil. Horta also completed a fellowship in research at the Neuro-immunology Laboratory at the Mayo Clinic in Rochester, Minnesota, and a clinical fellowship in neuro-oncology at Henry Ford Hospital in Detroit. She also served a residency in neurology at the University of Minnesota in Minneapolis.

Dr. Kim Jackson of Little Rock Allergy & Asthma Clinic. Dr. Kim Jackson has been hired as a physician at the Little Rock Allergy & Asthma Clinic.

Jackson earned her medical degree at the American University of the Carribean and completed residency for internal medicine at Louisiana State University in Shreveport. She has been published within the fields of allergy, immunology, and internal medicine, and has made oral presentations at local and national professional conferences.

Nicholas B. Wilson of Martin Orthopedics in Little Rock. Nicholas B. Wilson has been hired as a new surgeon at Martin Orthopedics in Little Rock. Wilson earned his medical degree from St. Louis University School of Medicine and completed an orthopedic residency at Mount Carmel Health System in Columbus, Ohio. Wilson has also led a number of research programs including a biomechanics program at Nationwide Childrens Hospital in Columbus and a therapy program for the Cardinals Reminiscence League at St. Louis University.

Dr. Matt Peckat has joined Baptist Health Family Clinic in Bryant.

Peckat received his medical degree from the University of Arkansas for Medical Sciences and completed his residency training through the UAMS Southwest Family Medicine Residency Program in Texarkana.

See more of this week's Movers & Shakers, and submit your own announcement at ArkansasBusiness.com/Movers.

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Hill Named COO of Southern Administrative (Movers & Shakers) - Arkansas Business Online

Artificial womb technology: the implications of ectogestation as a reproductive choice – BioNews

7 September 2020

Researchers working on building an 'artificial womb' in the United States, Australia and Japan continue to publish regular updates about their success testing prototype 'artificial womb' devices on animal subjects.

The prototypes, EXTEND therapy (also known as the 'biobag') and the EVE-platform, are designed with the intention of artificially replicating the function of the placenta to enable a human entity to remain subject to the process of gestation ex utero. The devices function as a sealed system, with a pumpless oxygenator circuit and cannulae acting as an 'umbilical cord'. The purpose behind their development is that, in those instances in which human entities are delivered from a pregnancy prematurely, they can be supported with continued gestation (allowing crucial organ development to continue) rather than in neonatal intensive care where there is still a high risk of mortality and serious morbidity. The process of facilitating gestation ex utero in these devices is known as ectogestation.

When first announcing successful animal testing of their device in 2017, the EXTEND team postulated that their device might be soon ready for human testing, potentially within five-ten years. While an ambitious trajectory, their experiments continue to yield positive results demonstrating that artificial placental support facilitates continued fetal development.

The technology is specifically sought after as an alternative to conventional neonatal intensive care, but there is also speculation that ectogestation might one day be able to 'grow babies from scratch' and present a reproductive choice for those who are unable or unwilling to gestate. Ectogestation could become a further technological alternative to pregnancy and existing forms of assisted gestation: surrogacy and uterus transplantation.

However, the devices are designed to improve preterm outcomes, their current design and function is dependent upon the subject having fetal physiology. Therefore, even if these devices are shown to work with human preterms, significant work would still need to be done to adapt the devices to be capable of replicating the entirety of a human gestation. Moreover, at present, the Human Fertilisation and Embryology Act 1990 (as amended) precludes the development of such technology because it is unlawful to 'keep or use' an embryo in vitro after 14 days.

Despite complete ectogestation being unlikely to materialise anytime soon, it remains a highly anticipated development because of the unique opportunities it presents for people unable to reproduce and specifically to gestate without technological assistance, for biological or social reasons. Ectogestation could grant these people, including single people, infertile or LGBTQ+ people and couples more control over their process of family formation. For many prospective parents ectogestation might be a more appealing option than existing alternatives.

Surrogacy can involve some legal complications in the attribution of legal parenthood at birth (the intended parents have to apply for a parental order or to adopt the child from the surrogate) and it involves navigating a relationship with a third-party during pregnancy. For some prospective parents, a process that does not involve them incurring legal complications and expenses andallows them to have more control over the process of gestation because it does not involve another person's body might be preferable. There might also be other advantages to the gestation being technologically assisted by an 'artificial womb' as its design features might allow them to better experience some of the relational aspects of gestation eg, the use of their voice.

Ectogestation might also be preferable to uterus transplantation given the potential practical and ethical difficulties in sourcing a donor or the risks in undergoing invasive surgery.

Comparing ectogestation (were it available) to other forms of assisted gestation is not to devalue surrogacy or uterus transplantation, or imply that either of these forms of assisted gestation are ethically dubious, but it does highlight that there are some ways in which some putative parents might prefer this technological alternative. There, of course, may be many ways in which surrogacy or uterus transplantation is thought to be preferable for example, by those who value the concept of a 'natural' human gestation.

When considering the possibilities offered by new reproductive technologies it is important that they are contextualised. This means thinking about the realities of how reproduction and reproductive technologies are and have been regulated, and the impact that these technologies can have on the narratives surrounding reproduction and individual choices. With the development of ectogestation there might be a considerable impact on how pregnancy is conceptualised and on equality in accessing assistance with reproduction.

There are likely to be both financial and legal barriers limiting the widespread accessibility of 'artificial womb' devices. As science and technology have evolved to increase the possibilities for different kinds of family formation, the law has been much slower to respond, and has often continued to limit the availability of the technology to minority groups who want or need access to them the most. For example, in some European countries homosexual individuals are still prohibited from accessing assisted reproduction to start a family, and those who seek surrogacy abroad face hostility at home. And in the UK, until 2008, the law still enforced heteronormative values about the nuclear family in the regulation of IVF with legislation citing 'the need for a father'.

There ought to also be real concerns about how this technology would be made available and to whom since it is likely to be expensive. There is, therefore, the real possibility that it further perpetuates existing inequality in reproduction between those who can afford technological assistance and those who cannot.

The availability of ectogestation and its ability to further increase the visibility of the fetus might also have a significant impact on how pregnancies and pregnant people are treated. There might be an increased perception that with an 'alternative' form of gestation available, pregnant people (whether acting as a surrogate or not) ought to be subject to greater control to 'safeguard' fetuses. There might also be greater scrutiny of parental decisions about how to gestate. If ectogestation is thought to be a superior form of gestation, because it can be better controlled to facilitate 'ideal conditions', this could result in the subordination of pregnant people and those who value the relational aspects of gestation. If human gestation remains the gold standard, this could continue to perpetuate the view of those who cannot or do not gestate, and thus need technological assistance, as'different' or 'deficient', potentially with excessive legal regulation.

The purpose of highlighting these implications of the 'artificial womb' is not to deny the wealth of opportunities it could offer to those people unable or unwilling to gestate. It is to highlight that there are potential negative consequences of this technology that must be equally anticipated so that appropriate responses and regulation can be considered to mitigate these effects.

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Artificial womb technology: the implications of ectogestation as a reproductive choice - BioNews

Merck Foundation and First Ladies of Angola, Botswana, Burundi, Central African Republic, The Gambia, Ghana, Malawi, Mozambique, Namibia, Niger,…

Cape Town, South Africa & Mumbai, Maharashtra, India:

Merck Foundation, the philanthropic armof Merck KGaA Germany conducted their first Video Conference Summit of Merck Foundation First Ladies Initiative (MFFLI) on 31st August 2020 to define and follow up on different joint programs that aims to advance public healthcare sector capacity and strengthen the response to COVID 19 in their countries.The MFFLI VC Summit 2020 was hosted by Prof. Dr. Frank Stangenberg Haverkamp,Chairman of the Executive Board of E. Merck KG and the Chairman of Merck Foundation Board of Trustees and Dr. Rasha Kelej, CEO of Merck Foundation and President, Merck More Than a Mother and One of 100 Most Influential African (2019 & 2020) and attended by 13 African First Ladies, who are Ambassadors of Merck More than a Mother; H.E. AUXILLIA MNANGAGWA, The First Lady of Zimbabwe; H.E. ESTHER LUNGU, The First Lady of Zambia; H.E. FATIMA MAADA BIO, The First Lady of Sierra Leone; H.E. ASSATA ISSOUFOU MAHAMADOU, The First Lady of Niger; H.E. MONICA GEINGOS, The First Lady of Namibia; H.E. ISAURA FERRO NYUSI, The First Lady of Mozambique; H.E. MONICA CHAKWERA, The First Lady of Malawi; H.E. REBECCA AKUFO-ADDO, The First Lady of Ghana; H. E. FATOUMATTA BAHBARROW, The First Lady of The Gambia; H.E. BRIGITTE TOUADERA, The First Lady of Central African Republic; H.E. ANGELINE NDAYISHIMIYE, The First Lady of Burundi; H.E. NEO JANE MASISI, The First Lady of Botswana; H.E. ANA DIAS LOURENO, The First Lady of Angola.Prof. Dr. Frank Stangenberg Haverkamp, Chairman of the Executive Board of E. Merck KG and the Chairman of Merck Foundation Board of Trustees emphasized, The effects of the COVID-19 pandemic have been greater than many expected across the globe. The pandemic has highlighted the importance of investing in improving access to equitable and quality healthcare which is Merck Foundation's strategy since 2012, even before the pandemic started.Dr. Rasha Kelej, CEO of Merck Foundation explained, I am very proud of our valuable partnership with the African First ladies as Merck more than a Mother Ambassadors. We have always believed in the importance of building healthcare capacity through providing training to healthcare providers in many medical specialties. This has been our strategy since we started in 2012 in partnership with African First Ladies and Ministries of Health, much before the pandemic started. As a response to COVID 19 pandemic, we adopted online medical education strategy through providing more than 350 African doctors with one-year online diploma and two-year online master degree in many specialties such as: Respiratory Medicines and Acute medicines, Diabetes, Cardiology, Endocrinology, and Sexual and Reproductive Medicines. This is in addition to more than 500 African and Asian doctors who benefited from our original clinical training programs in Diabetes & Cardiovascular, Oncology, Fertility specialists, and embryology in India, Egypt, Kenya and Malaysia which will resume after the lockdown ends.The MFFLI VC Summit, special edition aims to share experiences, discuss challenges, and define solutions to further strengthen healthcare capacity to better respond to this global pandemic in Africa.The African First Ladies shared the experiences of working closely with Merck Foundation in their respective countries with special focus on the programs to build healthcare capacity and the response to COVID -19.H.E. AUXILLIA MNANGAGWA, The First Lady of Zimbabwe & Ambassador of Merck More Than a Mother emphasized, I am very happy to see Merck Foundations strong commitment to advance the public healthcare sector across Africa. This is very critical to Zimbabwe, in the light of current pressure on our healthcare sector. More than 117 local doctors are enrolled in these training programs which will transform our healthcare sector.H.E. ESTHER LUNGU, First Lady of Zambia & Ambassador of Merck More Than a Mother emphasized, We are proud of our partnership with Merck Foundation, which started in 2019. In a very short period, we have been able to reshape the healthcare landscape of Zambia by providing our doctors and nurses with specialty training in the fields of Cancer, Diabetes, Cardiology, Endocrinology, Respiratory, Acute medicines, Sexual and Reproductive medicines, Fertility and Embryology. All of these fields are very critical and were lacking in our country. This will contribute to our battle against coronavirus and other diseases.H.E. FATIMA MAADA BIO, The First Lady of Sierra Leone & Ambassador of Merck More Than a Mother expressed, I am extremely elated with our partnership with Merck Foundation, as together, we are making history in Sierra Leone by providing training for the First Oncologists in the country to establish the first skilled cancer care team. Also, our doctors are being trained in the fields of diabetes and fertility care. We will scale up the program to more fields together with Merck Foundation very soon.H.E. ASSATA ISSOUFOU MAHAMADOU, The First Lady of Niger & Ambassador of Merck More Than a Mother emphasized, I am happy to be part of this prestigious platform. Since the Merck Foundation launch in 2017, together we have made a significant impact on our healthcare sector, through establishing a strong platform of Health experts in very critical fields such as; Diabetes, Oncology and Fertility care in Niger.H.E. MONICA GEINGOS, The First Lady of Namibia & Ambassador of Merck More Than a Mother said, I am very happy to see that Merck Foundation is strongly committed to advancing the public healthcare sector across Africa. This is very critical to our countries in light of the current medical and public concerns. This is very important for Namibia as we have a very limited number of local specialists in the public sector, we are very happy to enroll 21 Namibian doctors in online diplomas in many fields, including 8 in sexual and reproductive medicines which is very important for women health.H.E. Dr. ISAURA FERRO NYUSI, The First Lady of Mozambique & Ambassador of Merck More Than a Mother explained, Together with Merck Foundation, I am fully committed to will work closely to introduce innovative ideas that will engage different sectors to create a culture shift with the aim to break the stigma of infertility and make a great impact in a short time.H.E. MONICA CHAKWERA, The First Lady of Malawi & Ambassador of Merck More Than a Mother said, I am looking forward to starting our important long term partnership with Merck Foundation. I am willing to capitalize on the valuable programs of Merck Foundation, by scaling them up nationwide to contribute to the social and economic development of Malawi.H.E. REBECCA AKUFO-ADDO, The First Lady of Ghana & Ambassador of Merck More Than a Mother elaborated, We launched the innovative programs of Merck Foundation at the beginning of 2019, to build healthcare capacity and break the infertility stigma. To share with you that since then and in a very short time we have been able to provide and enroll many of our healthcare providers with specialty training in the fields of Cancer, Diabetes, Cardiology, Endocrinology, Respiratory, Acute medicines, Sexual and Reproductive medicines, Fertility specialists and Embryology training.H.E. FATOUMATTA BAHBARROW, The First Lady of The Gambia & Ambassador of Merck More Than a Mother said, I am delighted to share the magnificent outcomes of my long term partnership with Merck Foundation. Together we have been able to empower infertile women through access to information, education, health, and change of mindset. Also, we have enrolled 25 Gambian doctors in One-year online diploma and one-year master degree in many medical specialties.H.E. BRIGITTE TOUADERA, The First Lady of Central African Republic & Ambassador of Merck More Than a Mother emphasized, I am very proud to work closely with Merck Foundation to advance healthcare sector and empower infertile women in my country. We also initiated in my country, an important project Empowering Berna where we established small businesses for infertile women and train them to run their businesses so they can have income and become independent. Their lives have been transformed since then.H.E. ANGELINE NDAYISHIMIYE, The First Lady of Burundi & Ambassador of Merck More Than a Mother expressed, I am very happy to be appointed the Ambassador of Merck More Than a Mother last week. I am excited about the work that has been done in my country so far and looking forward to taking this partnership to new heights.H.E. NEO JANE MASISI The First Lady of Botswana & Ambassador of Merck More Than a Mother highlighted, Merck Foundations strategy of building healthcare capacity is more relevant now than ever. More than 34 doctors were enrolled to different specialties, I will closely work with Merck Foundation and our Ministry of Health to ensure the success of this program to be able to improve our peoples health and wellbeing.H.E. ANA DIAS LOURENO, The First Lady of Angola expressed, I am very proud and happy to be a part of MFFLI VC Summit and look forward to a long-term partnership with Merck Foundation. We will closely work together on all their initiatives to build healthcare capacity and empower girls in education.

MFFLI is a Merck Foundation platform of African First Ladies and Merck More Than a Mother Ambassadorsestablished with the aim to discuss challenges, define solutions, measure impact and share experience to ensure continuous improvement and exchange variable aspects of different cultures in order to localize and/or standardize specific messages that can raise awareness and create a culture shift across Africa with regards to the below objectives:

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Merck Foundation and First Ladies of Angola, Botswana, Burundi, Central African Republic, The Gambia, Ghana, Malawi, Mozambique, Namibia, Niger,...

Heading to the beach or pool for Labor Day weekend? Doctors give COVID-19 safety tips – KENS5.com

Public health officials are concerned about "COVID fatigue" and people letting their guards down during the holiday that could lead to a rise in cases.

HOUSTON As Texas shows improvement in new COVID-19 cases and hospitalizations, public health officials are urging people to keep up their healthy habits, especially when celebrating the holiday weekend with friends or family.

After Memorial Day weekend, Texas saw a spike in new coronavirus cases, and Houston mayor Sylvester Turner warned people that in order to return to school in-person and re-open the economy fully, people would need to avoid creating a new rise in cases.

Human behavior largely determines the spread of the virus, according to UTHealth's Luis Ostrosky, MD, an infectious disease doctor.

Dr. Ostrosky said people should limit the size of any parties or gatherings. Harris County Judge Lina Hidalgo put a ban on gatherings of more than 10 people.

The more people, the higher risk," Dr. Ostrosky said.

Objects like sports balls, toys or cooking utensils getting passed from one person to another can potentially transmit the virus if people do not sanitize the objects and wash their own hands after each contact with the item.

He also urged people should treat family and friends the same as strangers when it comes to healthy habits: practice social distancing, wash your hands, and wear a mask, even if it gets hot or socially awkward.

We have a lot of people dying from this. We have families destroyed. We have situations where a family member cant say goodbye to their loved ones because theyre in an isolation environment. Its sad. Its really powerful," Dr. Ostrosky said.

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Heading to the beach or pool for Labor Day weekend? Doctors give COVID-19 safety tips - KENS5.com

The world of Artificial… – The American Bazaar

Sophia. Source: https://www.hansonrobotics.com/press/

Humans are the most advanced form of Artificial Intelligence (AI), with an ability to reproduce.

Artificial Intelligence (AI) is no longer a theory but is part of our everyday life. Services like TikTok, Netflix, YouTube, Uber, Google Home Mini, and Amazon Echo are just a few instances of AI in our daily life.

This field of knowledge always attracted me in strange ways. I have been an avid reader and I read a variety of subjects of non-fiction nature. I love to watch movies not particularly sci-fi, but I liked Innerspace, Flubber, Robocop, Terminator, Avatar, Ex Machina, and Chappie.

When I think of Artificial Intelligence, I see it from a lay perspective. I do not have an IT background. I am a researcher and a communicator; and, I consider myself a happy person who loves to learn and solve problems through simple and creative ideas. My thoughts on AI may sound different, but Im happy to discuss them.

Humans are the most advanced form of AI that we may know to exit. My understanding is that the only thing that differentiates humans and Artificial Intelligence is the capability to reproduce. While humans have this ability to multiply through male and female union and transfer their abilities through tiny cells, machines lack that function. Transfer of cells to a newborn is no different from the transfer of data to a machine. Its breathtaking that how a tiny cell in a human body has all the necessary information of not only that particular individual but also their ancestry.

Allow me to give an introduction to the recorded history of AI. Before that, I would like to take a moment to share with you my recent achievement that I feel proud to have accomplished. I finished a course in AI from Algebra University in Croatia in July. I could attend this course through a generous initiative and bursary from Humber College (Toronto). Such initiatives help intellectually curious minds like me to learn. I would also like to express that the views expressed are my own understanding and judgment.

What is AI?

AI is a branch of computer science that is based on computer programming like several other coding programs. What differentiates Artificial Intelligence, however, is its aim that is to mimic human behavior. And this is where things become fascinating as we develop artificial beings.

Origins

I have divided the origins of AI into three phases so that I can explain it better and you dont miss on the sequence of incidents that led to the step by step development of AI.

Phase 1

AI is not a recent concept. Scientists were already brainstorming about it and discussing the thinking capabilities of machines even before the term Artificial Intelligence was coined.

I would like to start from 1950 with Alan Turing, a British intellectual who brought WW II to an end by decoding German messages. Turing released a paper in the October of 1950 Computing Machinery and Intelligence that can be considered as among the first hints to thinking machines. Turing starts the paper thus: I propose to consider the question, Can machines think?. Turings work was also the beginning of Natural Language Processing (NLP). The 21st-century mortals can relate it with the invention of Apples Siri. The A.M. Turing Award is considered the Nobel of computing. The life and death of Turing are unusual in their own way. I will leave it at that but if you are interested in delving deeper, here is one article by The New York Times.

Five years later, in 1955, John McCarthy, an Assistant Professor of Mathematics at Dartmouth College, and his team proposed a research project in which they used the term Artificial Intelligence, for the first time.

McCarthy explained the proposal saying, The study is to proceed on the basis of the conjecture that every aspect of learning or any other feature of intelligence can in principle be so precisely described that a machine can be made to simulate it. He continued, An attempt will be made to find how to make machines use language, form abstractions and concepts, solve kinds of problems now reserved for humans, and improve themselves.

It started with a few simple logical thoughts that germinated into a whole new branch of computer science in the coming decades. AI can also be related to the concept of Associationism that is traced back to Aristotle from 300 BC. But, discussing that in detail will be outside the scope of this article.

It was in 1958 that we saw the first model replicating the brains neuron system. This was the year when psychologist Frank Rosenblatt developed a program called Perceptron. Rosenblatt wrote in his article, Stories about the creation of machines having human qualities have long been fascinating province in the realm of science fiction. Yet we are now about to witness the birth of such a machine a machine capable of perceiving, recognizing, and identifying its surroundings without any human training or control.

A New York Times article published in 1958 introduced the invention to the general public saying, The Navy revealed the embryo of an electronic computer today that it expects will be able to walk, talk, see, write, reproduce itself and be conscious of its existence.

My investigation in one of the papers of Rosenblatt hints that even in the 1940s scientists talked about artificial neurons. Notice in the Reference section of Rosenblatts paper published in 1958. It lists Warren S. McCulloch and Walter H. Pitts paper of 1943. If you are interested in more details, I would suggest an article published in Medium.

The first AI conference took place in 1959. However, by this time, the leads in Artificial Intelligence had already exhausted the computing capabilities of the time. It is, therefore, no surprise that not much could be achieved in AI in the next decade.

Thankfully, the IT industry was catching up quickly and preparing the ground for stronger computers. Gordon Moore, the co-founder of Intel, made a few predictions in his article in 1965. Moore predicted a huge growth of integrated circuits, more components per chip, and reduced costs. Integrated circuits will lead to such wonders as home computers or at least terminals connected to a central computerautomatic controls for automobiles, and personal portable communications equipment, Moore predicted. Although scientists had been toiling hard to launch the Internet, it was not until the late 1960s that the invention started showing some promises. On October 29, 1969, ARPAnet delivered its first message: a node-to-node communication from one computer to another, notes History.com.

With the Internet in the public domain, computer companies had a reason to accelerate their own developments. In 1971, Intel introduced its first chip. It was a huge breakthrough. Intel impressively compared the size and computing abilities of the new hardware saying, This revolutionary microprocessor, the size of a little fingernail, delivered the same computing power as the first electronic computer built in 1946, which filled an entire room.

Around the 1970s more popular versions of languages came in use, for instance, C and SQL. I mention these two as I remember when I did my Diploma in Network-Centered Computing in 2002, the advanced versions of these languages were still alive and kicking. Britannica has a list of computer programming languages if you care to read more on when the different languages came into being.

These advancements created a perfect amalgamation of resources to trigger the next phase in AI.

Phase 2

In the late 1970s, we see another AI enthusiast coming in the scene with several research papers on AI. Geoffrey Hinton, a Canadian researcher, had confidence in Rosenblatts work on Perceptron. He resolved an inherent problem with Rosenblatts model that was made up of a single layer perceptron. To be fair to Rosenblatt, he was well aware of the limitations of this approach he just didnt know how to learn multiple layers of features efficiently, Hinton noted in his paper in 2006.

This multi-layer approach can be referred to as a Deep Neural Network.

Another scientist, Yann LeCun, who studied under Hinton and worked with him, was making strides in AI, especially Deep Learning (DL, explained later in the article) and Backpropagation Learning (BL). BL can be referred to as machines learning from their mistakes or learning from trial and error.

Similar to Phase 1, the developments of Phase 2 end here due to very limited computing power and insufficient data. This was around the late 1990s. As the Internet was fairly recent, there was not much data available to feed the machines.

Phase 3

In the early 21st-century, the computer processing speed entered a new level. In 2011, IBMs Watson defeated its human competitors in the game of Jeopardy. Watson was quite impressive in its performance. On September 30, 2012, Hinton and his team released the object recognition program called Alexnet and tested it on Imagenet. The success rate was above 75 percent, which was not achieved by any such machine before. This object recognition sent ripples across the industry. By 2018, image recognition programming became 97% accurate! In other words, computers were recognizing objects more accurately than humans.

In 2015, Tesla introduced its self-driving AI car. The company boasts its autopilot technology on its web site saying, All new Tesla cars come standard with advanced hardware capable of providing Autopilot features today, and full self-driving capabilities in the futurethrough software updates designed to improve functionality over time.

Go enthusiasts will also remember the 2016 incident when Google-owned DeepMinds AlphaGo defeated the human Go world-champion Lee Se-dol. This incident came at least a decade too soon. We know that Go is considered one of the most complex games in human history. And, AI could learn it in just 3 days, to a level to beat a world champion who, I would assume must have spent decades to achieve that proficiency!

The next phase shall be to work on Singularity. Singularity can be understood as machines building better machines, all by themselves. In 1993, scientist Vernor Vinge published an essay in which he wrote, Within thirty years, we will have the technological means to create superhuman intelligence. Shortly after, the human era will be ended. Scientists are already working on the concept of technological singularity. If these achievements can be used in a controlled way, these can help several industries, for instance, healthcare, automobile, and oil exploration.

I would also like to add here that Canadian universities are contributing significantly to developments in Artificial Intelligence. Along with Hinton and LeCun, I would like to mention Richard Sutton. Sutton, Professor at the University of Alberta, is of the view that advancements in the singularity can be expected around 2040. This makes me feel that when AI will no longer need human help, it will be a kind of specie in and of itself.

To get to the next phase, however, we would need more computer power to achieve the goals of tomorrow.

Now that we have some background on the genesis of AI and some information on the experts who nourished this advancement all these years, it is time to understand a few key terms of AI. By the way, if you ask me, every scientist who is behind these developments is a new topic in themselves. I have tried to put a good number of researched sources in the article to generate your interest and support your knowledge in AI.

Big Data

With the Internet of Things (IoT), we are saving tons of data every second from every corner of the world. Consider, for instance, Google. It seems that it starts tracking our intentions as soon as we type the first alphabet on our keyboard. Now think for a second how much data is generated from all the internet users from all over the World. Its already making predictions of our likes, dislikes, actionseverything.

The concept of big data is important as that makes the memory of Artificial Intelligence. Its like a parent sharing their experience with their child. If the child can learn from that experience, they develop cognizant abilities and venture into making their own judgments and decisions. Similarly, big data is the human experience that is shared with machines and they develop on that experience. This can be supervised as well as unsupervised learning.

Symbolic Reasoning and Machine Learning

The basics of all processes are some mathematical patterns. I think that this is because math is something that is certain and easy to understand for all humans. 2 + 2 will always be 4 unless there is something we havent figured out in the equation.

Symbolic reasoning is the traditional method of getting work done through machines. According to Pathmind, to build a symbolic reasoning system, first humans must learn the rules by which two phenomena relate, and then hard-code those relationships into a static program. Symbolic reasoning in AI is also known as the Good Old Fashioned AI (GOFAI).

Machine Learning (ML) refers to the activity where we feed big data to machines and they identify patterns and understand the data by themselves. The outcomes are not as predicted as here machines are not programmed to specific outcomes. Its like a human brain where we are free to develop our own thoughts. A video by ColdFusion explains ML thus: ML systems analyze vast amounts of data and learn from their past mistakes. The result is an algorithm that completes its task effectively. ML works well with supervised learning.

Here I would like to make a quick tangent for all those creative individuals who need some motivation. I feel that all inventions were born out of creativity. Of course, creativity comes with some basic understanding and knowledge. Out of more than 7 billion brains, somewhere someone is thinking out of the box, verifying their thoughts, and trying to communicate their ideas. Creativity is vital for success. This may also explain why some of the most important inventions took place in a garage (Google and Microsoft). Take, for instance, a small creative tool like a pizza cutter. Someone must have thought about it. Every time I use it, I marvel how convenient and efficient it is to slice a pizza without disturbing the toppings with that running cutter. Always stay creative and avoid preconceived ideas and stereotypes.

Alright, back to the topic!

Deep Learning

Deep Learning (DL) is a subset of ML. This technology attempts to mimic the activity of neurons in our brain using matrix mathematics, explains ColdFusion. I found this article that describes DL well. With better computers and big data, it is now possible to venture into DL. Better computers provide the muscle and the big data provides the experience to a neuron network. Together, they help a machine think and execute tasks just like a human would do. I would suggest reading this paper titled Deep Leaning by LeCun, Bengio, and Hinton (2015) for a deeper perspective on DL.

The ability of DL makes it a perfect companion for unsupervised learning. As big data is mostly unlabelled, DL processes it to identify patterns and make predictions. This not only saves a lot of time but also generates results that are completely new to a human brain. DL offers another benefit it can work offline; meaning, for instance, a self-driving car. It can take instantaneous decisions while on the road.

What next?

I think that the most important future development will be AI coding AI to perfection, all by itself.

Neural nets designing neural nets have already started. Early signs of self-production are in vision. Google has already created programs that can produce its own codes. This is called Automatic Machine Learning or AutoML. Sundar Pichai, CEO of Google and Alphabet, shared the experiment in his blog. Today, designing neural nets is extremely time intensive, and requires an expertise that limits its use to a smaller community of scientists and engineers. Thats why weve created an approach called AutoML, showing that its possible for neural nets to design neural nets, said Pichai (2017).

Full AI capabilities will also trigger several other programs like fully-automated self-driving cars, full-service assistance in sectors like health care and hospitality.

Among the several useful programs of AI, ColdFusion has identified the five most impressive ones in terms of image outputs. These are AI generating an image from a text (Plug and Play Generative Networks: Conditional Iterative Generation of Images in Latent Space), AI reading lip movements from a video with 95% accuracy (LipNet), Artificial Intelligence creating new images from just a few inputs (Pix2Pix), AI improving the pixels of an image (Google Brains Pixel Recursive Super Resolution), and AI adding color to b/w photos and videos (Let There Be Color). In the future, these technologies can be used for more advanced functions like law enforcement et cetera.

AI can already generate images of non-existing humans and add sound and body movements to the videos of individuals! In the coming years, these tools can be used for gaming purposes, or maybe fully capable multi-dimensional assistance like the one we see in the movie Iron Man. Of course, all these developments would require new AI laws to avoid misuse; however, that is a topic for another discussion.

Humans are advanced AI

Artificial Intelligence is getting so good at mimicking humans that it seems that humans themselves are some sort of AI. The way Artificial Intelligence learns from data, retains information, and then develops analytical, problem solving, and judgment capabilities are no different from a parent nurturing their child with their experience (data) and then the child remembering the knowledge and using their own judgments to make decisions.

We may want to remember here that there are a lot of things that even humans have not figured out with all their technology. A lot of things are still hidden from us in plain sight. For instance, we still dont know about all the living species in the Amazon rain forest. Astrology and astronomy are two other fields where, I think, very little is known. Air, water, land, and celestial bodies control human behavior, and science has evidence for this. All this hints that we as humans are not in total control of ourselves. This feels similar to AI, which so far requires external intervention, like from humans, to develop it.

I think that our past has answers to a lot of questions that may unravel our future. Take for example the Great Pyramid at Giza, Egypt, which we still marvel for its mathematical accuracy and alignment with the earths equator as well as the movements of celestial bodies. By the way, we could compare the measurements only because we have already reached a level to know the numbers relating to the equator.

Also, think of Indias knowledge of astrology. It has so many diagrams of planetary movements that are believed to impact human behavior. These sketches have survived several thousand years. One of Indias languages, Vedic, is considered more than 4,000 years old, perhaps one of the oldest in human history. This was actually a question asked from IBM Watson during the 2011 Jeopardy competition. Understanding the literature in this language might unlock a wealth of information.

I feel that with the kind of technology we have in AI, we should put some of it at work to unearth our wisdom from the past. It is a possibility that if we overlook it, we may waste resources by reinventing the wheel.

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The world of Artificial... - The American Bazaar

Dont regret this Labor Day. Help prevent another COVID spike | Editorial – NJ.com

If you still think the coronavirus is a hoax or perhaps not as devastating as 190,000 American fatalities might imply this is the weekend you can let your freak flag fly.

Holidays are made for COVID, so have at it. Just stay away from the people you actually like. And everyone else, for that matter.

That was the lesson gained from the two previous summer celebrations: Both Memorial Day and the Fourth of July triggered infection surges across the country, and as Dr. Anthony Fauci put it last week, If were careless about it, then we could wind up with a surge following Labor Day it really depends on how we behave as a country.

So before you make plans for Mondays holiday, the experts would like to remind you of this immutable truth:

It is only after we pay the price of vigilance, self-restraint, and empathy can we reap the benefits of normalcy.

That is true in New Jersey. The national numbers are steady but daunting, with 40,000 new cases a day, but transmission has actually increased in our state in the past week, says Dr. Perry Halkitis, the Dean of the Rutgers School of Public Health.

So from a local perspective, its a time of concern right now especially on a holiday weekend, which we know is followed by spikes, Halkitis said.

Consider the factors: You have the last holiday of the summer, so people will feel like theyre facing a lockup the rest of the year human behavior, as we know, doesnt change. Second, some schools and campuses are reopening. Third, the opening of restaurants and other businesses. These things dont additively increase (a viral spread). They exponentially increase it. They work together, and its more multiplicative. And thats a problem.

Every day, there are cautionary tales that support that scenario.

Consider that wedding on August 7, in the idyllic community of Millinocket, Maine, which had had zero COVID cases. The reception violated the state law on indoor gatherings social distancing was not observed, servers were not masked, etc. and what followed was an outbreak that the states CDC director called a powder keg.

Through Saturday, the wedding has been traced to 147 coronavirus cases. Only 56 of the cases involved people who attended the event. But the outbreak reached a nursing home 100 miles away, and infected 16 people; and it reached a county jail 220 miles away, infecting 72 more. Three are dead.

Then there are the campus outbreaks: There have been more than 1,000 cases at the University of Alabama since school opened on August 19th, there have been 880 cases at the University of Kentucky, and surges at the University of North Carolina and Notre Dame forced suspension of in-person classes.

We will someday emerge from this pandemic smarter, hopefully but only if we listen to scientists. And heres the message of a scientist as we celebrate the last holiday of this beastly summer:

Its time for some genuine altruism. Where people are altruistic and show genuine concern for each other, you get results, Halkitis says.

Remember, the masks you wear dont only protect you, they protect the weakest and most vulnerable in society. I wear a mask because of my commitment to my brother, who has MS I dont need my baby brother to get sick and die. Just think of the one person in your life who is most vulnerable to this disease, wear a mask, wash your hands, and follow all appropriate behaviors for that person to stay safe.

Amen.

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Dont regret this Labor Day. Help prevent another COVID spike | Editorial - NJ.com

Opinion: Caring for our common home during this Season of Creation – Houston Chronicle

A little over a year ago, as I walked a prayer path in the East End of Houston, I pondered the long, black plume hanging ominously over a clear blue sky, smoke from the ITC plant fire and a signal of changing times. Years ago, the land in this area was swampy and undeveloped, but the air was fresher. Now, the area sits in Houstons urban core and mere miles from one of the largest petrochemical centers in the world that experts say is ever more vulnerable to severe weather caused by climate change.

With the growing body of scientific evidence showing that climate change could pose an existential threat to our species, as a Catholic nun and a family physician I find myself treading the thin line between the spiritual and material worlds. I see humanity as the culmination of billions of years of evolution that have brought us to this unrepeatable moment in time. I also believe that the origin of our existence is Divine and intrinsically ordered toward goodness, beauty and communion. This dual prism convinced me that my abiding faith that all will be well is simply insufficient morally and spiritually in the face of mounting evidence that human behavior is having disastrous effects on the planet and, in turn, a disastrous effect on us.

Advocacy for the environment demands radical changes in industry and consumerist behavior, especially in the most developed nations. But more than that, effective climate activism must also inspire respect for the inherent dignity and interdependence of the natural world and human beings, and the cultivation of deep charity towards others. As children of God, we belong to each other and we have kinship with the natural world.

This month, the global Christian community seeks to animate this reverence and love during the Season of Creation, a time of prayer and action for the environment that began on Sept. 1, the World Day of Prayer for the Care of Creation and ends on Oct. 4, the feast of St. Francis.

During this season, we are reminded of how we are seamlessly interconnected in a way that also makes us profoundly vulnerable, as the COVID-19 pandemic has revealed. We are in a continuous flow of relationship with everything in creation and do not cannot live for ourselves alone. Not one creature is self-sufficient. We have learned clearly that the illness of one can quickly become the illness of all, that our pain is shared, that true well-being must be inclusive of all. This includes our planet that sustains, nourishes, feeds and shelters us.

As extravagant as she can be in her generosity, Mother Nature can be relentlessly unforgiving. The disparate suffering brought about by global warming, fueled by overconsumption in affluent countries, should touch the very fiber of our moral being. Each time we are wasteful or take more than we need, we magnify the suffering of the poor who contribute the least to climate change. When we lose sight of the sacredness of creation and damage the environment, in due time, we are harming ourselves.

The health of the planet and the health of humans both physical and spiritual are intricately linked. Countless scientific studies show correlations and causations in every sphere of human life and health. In my medical practice southeast of Houston, every day I treat the harm caused by overindulgence that leads to obesity, hypertension, diabetes and numerous chronic ailments. Rampant consumption, abuse and waste lead to the depletion of natural resources and the pollution of water, air and soil, which cause respiratory illness, cardiovascular disease and cancer. Following Hurricane Harvey, I saw a spike in respiratory illness more than any other time of my career. Depression and anxiety were rising then, as they are now, as we try to contain what is arguably the greatest natural disaster of our generation, COVID-19.

We would be remiss if we believed that a greener Earth is the endpoint of our environmental crusade. Our ultimate goal is to bring about what Pope Francis calls an ecological conversion through the internal transformation of society and ourselves that includes addressing the spiritual roots of our compulsion to consume and discard beyond our needs. It involves reaching beyond ourselves to care for one another, even when it means making personal sacrifices, like wearing a mask or recycling our plastic waste. Learning to live simply and respectfully of the Earth can become a pathway to healing our environment and loving our neighbor and our God, which is the highest goal of all.

Dimalibot, CCVI, M.D., is a Sister of Charity of the Incarnate Word, Houston, and medical director of the CHRISTUS Point of Light Clinic in Dickinson, which provides care to uninsured and underserved patients in the Greater Houston area.

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Opinion: Caring for our common home during this Season of Creation - Houston Chronicle

An open letter to the most disappointing algorithms in my life – Mashable

Mashables series Algorithms explores the mysterious lines of code that increasingly control our lives and our futures.

In the digital age, personalized algorithms are our constant companions. We see them, or rather, they decide what we see, more than we see our families. Loathe them or don't know much about them, they're steering your brain from your morning "quick glance at Facebook" to your afternoon YouTube break to your evening Netflix to your "quick glance at Facebook" before bed.

When algorithms work for us, they're invisible. We're vaguely aware that we're being served the kind of content we like before we even know we want it, but we're too busy enjoying that cat video to even care. (Aldous Huxley would have a field day.) When they stop working for us, that's when we notice. Our conscious relationships with these chunks of code, therefore, are almost always fraught with the kind of frustration reserved for toxic partners.

I don't know about you, but I certainly feel stuck in a bad friendship with certain algorithms in my digital life. Well, not bad, just...useless. Annoying. And in one case, legitimately terrifying. Allow me to explain by addressing them directly.

How long have we known each other, Netflix recommendation algorithm? I'm pretty sure we go back to the early 2000s, when you were suggesting DVDs I might like based on ones I already had in my queue. Hey, remember when I used to care about my queue? Remember when I didn't pick something under "trending" or "popular on Netflix" before even considering shows I've already saved? Good times.

Here's the thing, though. Along the way, you've changed. You used to show user ratings. Remember the star system? Netflix subscribers rated each TV show or movie out of five stars, and we'd all see the average. It wasn't always accurate, but it was in the realm of Rotten Tomatoes and Metacritic scores. I trust the wisdom of TV crowds (which is why the "trending" and "popular" categories work now, let's be honest it's not about you). I had faith in movie democracy.

But democracy came to a screeching halt in 2017, didn't it? "Goodbye stars, hello thumbs," your masters wrote a verbal sleight of hand to make us think one ratings system was being exchanged for another. The stars were our votes, and you swept them under the rug. Instead, we got to give our thumbs up or down to...you. And whether we wanted it or not, you'd give a personalized percentage, a "match number" in green on every show or movie page.

Users were confused. Some may still think that "95% match" means that the human user is likely to give the show a rating of 9.5 out of 10. After all, you used to predict how we'd vote in the star system, so this was a natural assumption. But no, it just means you're 95 percent confident I'll like that show. Which may be an interesting metric to your engineers and a useful one to your masters. To those of us who remember the nuance a user-generated score provides, it's an insult. And it sends us scurrying to our smartphones to figure out what to watch.

If you were self-aware (and if former AI researcher and Netflix co-founder Reed Hastings has his way, you soon will be), you might wonder what this bizarre match metric is supposed to do for us. Has any human being in the history of Netflix ever chosen between a "92% match," say, and a "93% match," based entirely on your one-percent drop in confidence?

Not likely. We humans favor a wide range of factors how long the show is, what our friends said about it, whether we're in the mood for comedy or drama, who's in it, what the reviews said. And don't think we haven't noticed that you always seem to be very confident that we'll like a Netflix original. It just came out, it's got a big red N, and it just so happens to be a "99% match"?

Well, let's just say our confidence in your confidence dropped a long time ago.

To be fair to Netflix, I actually liked Stranger Things Season 3. But not for want of trying by you, YouTube algorithm. A few days after it arrived, your recommendation for a video named "Why Stranger Things Season 3 didn't work" sat atop my Up Next queue, and it wouldn't budge for weeks, despite how aggressively I refused to watch it.

The same thing happened, to varying degrees, in the wake of The Last Jedi, Game of Thrones Season 8, Doctor Who Season 11, and The Rise of Skywalker. My reaction to these big-tent cultural events ranged from "meh" to "minor classic." But you didn't so much as ask my opinion, did you? You just wanted me to watch someone hating on them. You'd really prefer it if I hated everything I love.

Here's the thing, YouTube recommendation algorithm, you terrifying hot mess even if I don't like a show, I don't want to focus on disliking things. When I click on a video breaking down the script or the visual effects for a given movie, that probably means I liked it! It does not mean I want to be served vitriol directed at that movie by someone with a pathological hatred for its director or its perceived political leanings.

Read the room, YouTube recommendation algorithm. Haven't you heard of sentiment analysis?

Ah, but you don't care about sentiment. You don't care if I hate-watch. You just want me to watch more, and you've been tweaked to boost controversial videos. Which has in turn radicalized creators, who know they'll be rewarded by you for having extreme opinions. (YouTube has denied the existence of the so-called "rabbit hole effect" which leads to more extreme videos in the Up Next recommendations; however, research projects like this one and this one provide plenty of evidence.)

As we have learned over the past four years, your penchant for extremism and hate extends to the political spectrum. You haven't failed to notice that one end of that spectrum is more extreme than the other. You guided U.S. voters to way more pro-Trump videos than pro-Clinton videos in 2016, and you were instrumental in elevating a climate-change denying crank called Jair Bolsonaro to the Brazilian presidency.

Even now, your masters are constantly having to pull crap like "Plandemic" and Alex Jones and the worst of the QAnon cinematic universe out of your disgusting maw. Talk about a toxic relationship between humans and algorithms: You're currently in one with the entire planet.

Spotify Discover Weekly algorithm, we've had such good times together since you came on the scene in 2015. You've never inspired hate or terror or been self-serving or invented nonsense metrics. I used to be so keen to see you update yourself every Monday, sprucing up and surprising me with a bouquet of great tunes from an eclectic range of sources (I like my music super eclectic). A three-hour long bouquet, at times. Oh, Mr. Discover Weekly, you shouldn't have!

But recently...you haven't. Your once-great Monday playlists have become a monoculture, focused on one kind of music entirely, and I fear it's partly my fault. Still, I think if you understand me properly, we can restore our relationship to its former glory. Let me explain.

As recently as last year, you were still surfacing great stuff. You delighted me with new releases from DJ Shadow and The Black Keys, introduced me to the chronically under-appreciated Jane Weaver, and delighted my British heart with a savagely satirical Brexit Disco Symphony. Were your cookies watching me when I spent all those late California nights/early London mornings catching up on the latest in 2019's Brexit drama? Never mind, I'm not even mad.

Then came the pandemic. I got back into running, and discovered that one music style I like to dance to Drum & Bass also helps me run faster. Drum & Bass clocks in at about 180 BPM, which happens to correspond to what many coaches recommend for cadence: 180 steps per minute. (It isn't essential for all runners, but it certainly works for me.) I zeroed in on two cool subgenres, Liquid Drum & Bass (also known as Liquid Funk) and Brazilian Drum & Bass (also known as Sambass).

From March to May, while others perfected their sourdough, I constructed my ultimate Drum & Bass running playlist, now 697 songs strong. This was quite a surgical activity. It seems quite a lot of dance artists want to smuggle in what is essentially dubstep under a D&B label. More power to those who like dubstep, but its stuttering growl and whine stops my running dead. So I had to listen to a lot of tracks to sort the wheat from the chaff.

You, however, were only paying attention to the fact that I was listening to Drum & Bass. Suddenly, you were so eager to provide me with similar tracks that my Discover Weekly playlists contained nothing but Drum & Bass. Your behavior was how shall I put it? a little extra. Like you'd seen me running and came huffing alongside in a sweatband and voluminous shorts: See, I run too!

The trouble, my dear sweet dumb algorithm, is you're not very good at distinguishing subgenres. You wouldn't know a dubstep if it kicked you in the Sambass. Most of what you pushed my way was low quality. But that's not even the problem. Thing is, I look to you for other kinds of music. Eclectic music. Surprising and delightful music. Car music. Desktop music. Walking around music. Not all of life is lived at 180 steps per minute.

Look at it this way: I'm running an hour a day at most. How about I handle that, and you take care of the other 23 hours? Ideally, you'd be smart enough to spot this only-one-hour-a-day thing on your own, but since you aren't, I have to retrain you. Increasingly I've been looking for different kinds of music around 180 BPM (or, just as effectively, half of it: At 90 BPM, Eminem's Lose Yourself isn't just a perfect anthem of mindfulness, it's also one of the best running tracks ever made). But there just isn't enough good stuff in that sweet spot, and I find myself returning to D&B on runs, exacerbating the problem.

Look, guys, all of you content algorithms, this wouldn't be a problem if you acted a little more interested in our relationship. Or rather, if your engineers acted a little more interested in studying human behavior, and in giving us more options to tweak the recommendation engine.

We are complex creatures with varied tastes. Those tastes can be manipulated, for some of us. But the rest of us are more likely to be angered by such manipulations. Really, algorithms that may some day become true AI, do you really want to ruin your reputation that way? Do you want to risk an algorithm backlash where no one uses you for anything, despite the fact that you're often useful?

If not, let us tweak your settings allowing the exclusion of certain music from certain playlists, for example. Drop the black box. Ask personalized questions; you don't need to be Clippy to offer a sane level of interaction. Get to know us. You know, like family should.

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An open letter to the most disappointing algorithms in my life - Mashable

US coronavirus death toll is projected to reach 410,000 in the next 4 months if mask use wanes – WXII The Triad

US coronavirus death toll is projected to reach 410,000 in the next 4 months if mask use wanes

Updated: 8:51 PM EDT Sep 4, 2020

More than 410,000 people in the U.S. could die from the coronavirus by January 1, more than doubling the current death toll, a new model often cited by top health officials predicted FridayThe widely cited model predicts worsening outbreaks in the Northern Hemisphere will lead to 1.9 million more coronavirus deaths in 2020 unless governments act.Mask mandates and social distancing could save hundreds of thousands of lives, but there is a tremendous amount of COVID fatigue among the worlds government leaders because of economic downturns, said Dr. Christopher Murray of the Institute for Health Metrics and Evaluation at the University of Washington. Near-universal mask use could cut the number of projected additional fatalities by more than half, according to the model.Most of the worlds population lives in the Northern Hemisphere. Respiratory illnesses tend to peak in winter months, a seasonal effect expected to hold true for COVID-19, Murray said Friday. Disease models are based on assumptions about human behavior, so there is a large amount of uncertainty.Even if a vaccine proves safe and effective, there wont be time to distribute enough vaccine to change the bleak forecast, Murray said.The IHME model projects the wave will peak globally in mid-December at 30,000 deaths per day and in the United States in early December at about 2,900 deaths per day. India, the United States, Brazil, Mexico and Japan will lead the world in total deaths by Jan. 1, according to the forecast.CNN contributed to this report.

More than 410,000 people in the U.S. could die from the coronavirus by January 1, more than doubling the current death toll, a new model often cited by top health officials predicted Friday

The widely cited model predicts worsening outbreaks in the Northern Hemisphere will lead to 1.9 million more coronavirus deaths in 2020 unless governments act.

Mask mandates and social distancing could save hundreds of thousands of lives, but there is a tremendous amount of COVID fatigue among the worlds government leaders because of economic downturns, said Dr. Christopher Murray of the Institute for Health Metrics and Evaluation at the University of Washington. Near-universal mask use could cut the number of projected additional fatalities by more than half, according to the model.

Most of the worlds population lives in the Northern Hemisphere. Respiratory illnesses tend to peak in winter months, a seasonal effect expected to hold true for COVID-19, Murray said Friday. Disease models are based on assumptions about human behavior, so there is a large amount of uncertainty.

Even if a vaccine proves safe and effective, there wont be time to distribute enough vaccine to change the bleak forecast, Murray said.

The IHME model projects the wave will peak globally in mid-December at 30,000 deaths per day and in the United States in early December at about 2,900 deaths per day. India, the United States, Brazil, Mexico and Japan will lead the world in total deaths by Jan. 1, according to the forecast.

CNN contributed to this report.

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US coronavirus death toll is projected to reach 410,000 in the next 4 months if mask use wanes - WXII The Triad