Sensei Biotherapeutics Reports Early Data from Phase 1/2 Clinical Trial of SNS-301 in Combination with Pembrolizumab in Advanced Head and Neck Cancer…

DetailsCategory: DNA RNA and CellsPublished on Sunday, 20 September 2020 11:04Hits: 162

SNS-301 demonstrated early signals of anti-tumor activity correlated with immune response and tumor infiltration

BOSTON, MA & GAITHERSBURG, MD, USA I September 18, 2020 I Sensei Biotherapeutics, Inc., a clinical-stage biopharmaceutical company developing personalized yet off the shelf immunotherapies for cancer and infectious diseases, announced today results from the Phase 1/2 clinical trial evaluating the safety, efficacy, and immunogenicity of SNS301, a first-in-class bio-engineered, inactivated bacteriophage, in patients with Locally Advanced Unresectable or Metastatic/Recurrent Squamous Cell Carcinoma of the Head and Neck (SCCHN). The data were presented in a poster discussion session at the European Society for Medical Oncology (ESMO) Virtual Congress 2020.

Patients with SCCHN often present with immune desert or excluded tumors and only 13-16% of the patients respond to anti PD-1/PDL-1 therapy. Data from the KEYNOTE-012 clinical trial demonstrated that SCCHN patients receiving pembrolizumab alone as 2nd line treatment or later have an objective response rate of 18%, median overall survival of 8 months, and progression-free survival of 2 months. Only 6% of patients with PD-L1 negative disease achieve an objective response to pembrolizumab.

The efficacy of anti-PD-1/PD-L1 is attributed to the presence of infiltrating antigen-specific CD8+ T-cells. Combining anti-PD-1/PD-L1 with agents that generate or expand anti-tumor T-cells, such as vaccines, is critical to increase overall survival of SCCHN patients, said Marie-Louise Fjaellskog, M.D., Ph.D., Chief Medical Officer of Sensei Biotherapeutics. To date, we have observed promising clinical activity that is correlated with immune response for SNS-301, including a partial response in a patient with PD-L1-negative disease. This initial data from 9 patients provides us with the rationale to continue exploring its safety and efficacy in 1st and 2nd line SCCHN patients.

We are excited by the emerging translational data for SNS-301, including - in a patient with a confirmed response - a clear conversion from a poorly inflamed tumor into an inflamed microenvironment, characterized by significant T cell infiltration, and upregulation of PD-L1, said Robert Pierce, M.D., Chief Scientific Officer of Sensei Biotherapeutics. Based on these early promising results, we plan to expand our Immunophage platform to include additional tumor associated antigens and to combine these into bespoke vaccine cocktails based on a patient tumors genetic profile.

The ongoing multi-center Phase 1/2 clinical trial of SNS-301 in combination pembrolizumab is designed to assess the safety, efficacy and immunogenicity of SNS-301 in SCCHN patients that had received anti-PD1/PD-L1 therapy for at least 3 months prior to enrollment with stable disease or unconfirmed progressive disease as their best response upon entry into the study.

Highlights of the Safety, Efficacy and Immunogenicity Data as of July 23, 2020 include:

Based on these data, Sensei plans to enroll all 30 patients for this study. An additional study in neoadjuvant SCCHN patients is planned to begin early next year in combination with Imfimzi (durvalumab).

About SNS-301

SNS-301 is a first-in-class cancer immunotherapy designed to overcome immune tolerance and induce robust and durable antigen-specific humoral and cellular responses. It is a bio-engineered, inactivated bacteriophage virus expressing a fusion protein of native bacteriophage GPD (Glyceraldehyde-3-phosphate dehydrogenase) protein and a selected domain of aspartate -hydroxylase (ASPH). Expression of ASPH is uniquely upregulated in more than 20 different types of cancer and expression levels in various tumors are generally inversely correlated with disease prognosis ASPH signaling is related to cancer cell growth, cell motility and invasiveness, occurs through the Notch pathway, and is implicated in the epithelial to mesenchymal transition (EMT).

About Sensei Biotherapeutics

Sensei Biotherapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development and delivery of precision immunotherapies. The company has developed a unique phage-based platform, ImmunoPhage, that enables the generation of immune activating agents that fully engage the immune system. Its most advanced program, SNS-301, is currently enrolling patients in Phase 2 clinical trials. The company brings together scientific leaders in biology, immunology, and oncology along with a highly experienced management team and scientific advisors. For more information, please visit http://www.senseibio.com.

SOURCE: Sensei Biotherapeutics

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Sensei Biotherapeutics Reports Early Data from Phase 1/2 Clinical Trial of SNS-301 in Combination with Pembrolizumab in Advanced Head and Neck Cancer...

From Bike Blockers to Street Medics: The Anatomy of an N.Y.C. Protest – The New York Times

Only a few weeks after the first of what would become near-daily Black Lives Matter protests in New York City, Justina Heckard found herself on her bicycle in Brooklyn, leading a march in loose formation with other cyclists. An altercation with a driver left a protester injured, and Ms. Heckard and her fellow demonstrators decided they would need to sharpen their tactics.

As protest organizers learned to handle everything from physical confrontations to dehydration, they developed strategies and clearly defined roles designed to keep marches on track and participants safe.

Some of these tactics, however, can put protesters in direct confrontation with both the police and bystanders.

Heres a breakdown of some of the most common roles.

At a demonstration last month, Larry Malcolm Smith Jr., noticed a female protester quarreling with a photographer. She had told the man that she didnt want to be photographed, Mr. Smith recalled. Although he had a right to photograph in public, the photographer seemed to be unusually aggressive.

As a marshal, Mr. Smith, 21, was there to make sure that the demonstration ran smoothly. He intervened in the argument and told the photographer to move away from the woman.

Mr. Smith said he tries to pay attention the needs of Black women. There needs to be more Black men that come out and show up for Black women, he said.

Marshals tend to be scattered throughout a march often equipped with bullhorns and are there to answer questions and keep the energy alive in the middle and back end of a protest.

Born in Jamaica, Queens, Mr. Smith began protesting at age 8, after Sean Bell, an unarmed Black man, was shot by plainclothes officers in Mr. Smiths neighborhood.

I dont feel like I chose activism, he said. Activism chose me.

In early June, Justina Heckard, who works as a music manager, took her bike to demonstrations as a social distancing measure. She said she was soon asked to help divert traffic along with other bike protesters.

At a march on June 6 in Crown Heights, Brooklyn, Ms. Heckard, 32, and a dozen other cyclists pedaled ahead to clear a route. It was there, she said, that they crossed paths with a motorist who refused to take another street and threatened to drive through the incoming marchers.

With their fellow protesters approaching, the cyclists didnt know how to respond. One stood in front of the car, as shown in a video of the incident, and another tried to jump on the cars roof.

A few seconds later, Ms. Heckard said, the driver accelerated, injuring one protester. That night, demonstrators realized bicyclists needed to be better prepared if they were going to be the first line of defense against motorists.

Now, bike blockers work to de-escalate tensions when they meet uncooperative motorists and form tight lines to block traffic.

This tactic, however, is technically not allowed without a permit, which most protests lack. For the safety of all New Yorkers, we cannot support any blocking of traffic that is not authorized by a government agency, said a spokeswoman for the Police Department.

The danger posed by bike blocking doesnt concern Brandon English, 31, a visual artist. Growing up in Cobb County, Ga., Mr. English recalled being heckled and verbally threatened by white drivers on his way home from school.

Thats something thats been understood for me as a Black person in the United States, Mr. English said. Whether Im protesting or not, my life can be in danger.

Robert Thorne was volunteering at the medical tent at Occupy City Hall in July when he heard that a protester on the Brooklyn Bridge had sustained a head injury after falling off a bike. Mr. Thorne, 33, who has a background as an emergency medical technician, got to the bridge before the ambulance and tended the protesters wounds.

Now, along with his wife, Laney Thorne, 31, he joins protests across the city as a street medic, walking along the edges of the march, ready to treat wounds and help people exposed to pepper spray.

Street medics carry backpacks, usually marked with red crosses, stuffed with first-aid supplies.

Mr. Thorne and his wife came to New York from their home in Elkhart, Ind., after they both lost their jobs because of the pandemic.

Mr. Thorne said his commitment against police brutality had intensified after helping as a street medic: If this goes on in the wintertime, Ill be out there, said Mr. Thorne. I have no intention of stopping any time soon.

Kevin Mora, a lab technician, joined protests as a street medic in May. But in early June, while helping a protester who was exposed to pepper spray, Mr. Mora searched through his backpack only to realize he didnt have any water with him. As he began to panic, a protester from a supply crew rushed over with a bottle of water.

Mr. Mora, 23, said it made him realize there was work to be done at protests aside from moments of crisis, and led him to start Your Fight Too, a mobile bodega that provides supplies everything from masks, food and water to feminine hygiene products.

Mr. Mora, who is Ecuadorean and bisexual, grew up in a culturally homogeneous town Easton, Conn., said his participation in the protests had made him question what it means to be an ally: Ive been re-evaluating the word..

He used to be more concerned, he said, with how others were being allies for him.

Now he asks himself: How have I been an ally in return?

At a demonstration in August, Erica Johnson, who attended as a legal observer, watched as officers approached two protesters who were driving behind the march to help control traffic. She started recording the interaction in her notebook. One of the officers who had approached the car noticed Ms. Johnson and then walked away.

Legal observers attend demonstrations to document interactions between protesters and police officers. They also connect protesters to legal representation and help those who are arrested.

Civilian observers are allowed, according to the New York Police Departments Patrol Guide.

We welcome legal observers and encourage their coordination, a police spokeswoman said in an email. Still, legal observers are subject to arrest: At a June 4 demonstration, nine legal observers were arrested.

Later that month, the police commissioner, Dermot Shea, defended the arrests during testimony before New Yorks attorney general, Letitia James.

Having a shirt or a hat that says legal observer doesnt mean theyre an attorney, Mr. Shea said, or theyre actually performing any legal functions.

Ms. Johnson is a brand manager at a marketing company and has been volunteering with the National Lawyers Guild for nearly a decade. She said she had noticed a greater demand for legal observers at protests in recent months.

Especially when its my own community, I feel like I have to show up a lot more, she said. I feel like I cant do enough.

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From Bike Blockers to Street Medics: The Anatomy of an N.Y.C. Protest - The New York Times

Anatomy of a powerhouse: Expectations at Ohio State now go beyond the Big Ten and Rose Bowl – Suburbanite

Editors note: How did Ohio State football become a Buckeye Nation of true believers? In a 14-part series, we explore aspects that shaped OSUs evolution from Saturday afternoon diversion to near-religious experience. Today: Chase

Not even two Heisman Trophies can bookend the regret that slides off the shelf of Archie Griffins most painful Pasadena memory, when undefeated Ohio State lost to underdog UCLA in the 1976 Rose Bowl, costing the Buckeyes a national championship.

"Thats the one that haunts me," Griffin said, grimacing more from the recollection of that 23-10 loss than from the sore back that now hampers his golf game.

The Buckeyes were ranked No. 1 in both the Associated Press and United Press International polls, had defeated the Bruins 41-20 in the Los Angeles Coliseum earlier in the season and entered the New Years Day game as two-touchdown favorites.

Yet despite coming up short again Griffin finished 1-3 in Rose Bowls, with two lost chances at national titles the former tailback would not describe 1975 as a failed season just because the Buckeyes were not voted No. 1.

"It cant be national championship or bust," he said.

It cant? Try telling that to Ohio State fans too young to recall when a successful season could be defined by a win over Michigan and playing in the Rose Bowl. These days, anything short of a College Football Playoff appearance, culminating in a national championship, leaves many fans, players and coaches feeling frustrated.

Before the Big Ten reinstituted football on Wednesday, Ohio State coach Ryan Day tweeted " we still have an opportunity to give our young men what they have worked so hard for: a chance to safely compete for a national championship this fall."

Woody Hayes did not think that way. The former OSU coach considered a national championship the outcome of a special season not the goal. Win the Big Ten and Rose Bowl and the chances of being voted poll champions were pretty good.

But there were no guarantees, which explains why Hayes and the next two Buckeyes coaches, Earle Bruce and John Cooper, focused their attention more on winning the conference than winning a national championship that was decided by media and coaches poll voters. During Hayes time, and before, voting to determine the "national champion" took place before the bowl games were played.

As Griffin explained it, "You could win your bowl game and might win the national championship, but it in the end it was still up to the voters."

Cooper learned that the hard way in 1996 the penultimate season before the Bowl Championship Series began when the Buckeyes lone blemish was a 13-9 loss to Michigan in The Slip game. Ohio State dropped from No. 2 to No. 4 in the polls, then defeated No. 2-ranked Arizona State 20-17 in the Rose Bowl.

Cooper hoped voters would bump the Buckeyes to No. 1, but OSU finished No. 2 to Florida after the Gators defeated No. 1 Florida State 52-20 in the Sugar Bowl.

"Im envious of the (playoff) system," the 83-year-old Cooper said. "I had a couple teams that, Im not saying they would have won it but they would have played for the national championship."

Cooper admitted, however, that such wishful thinking fails to consider context and a changing win-at-all-cost culture.

"Times have changed," he said. "The goal back then seemed like it was win your games, beat Michigan and go to the Rose Bowl. It used to be you win the Big Ten, youre going to play in the Rose Bowl.

"I coached at Oregon State and UCLA, and even out there the goal was to go to the Rose Bowl. Bowls were a reward for a good season. Later on, it became you had to win the Rose Bowl."

The BCS changed everything when it arrived in 1998, pitting No. 1 vs. No. 2 in a championship game that removed some subjectivity from the equation. Schools still had to be voted into the top two spots, but the title was decided on the field.

By the time Ben Hartsock arrived at Ohio State, in 1999, the tight end already had put most of the Rose Bowl mystique in his rearview mirror. He grew up listening to his father rave about "The Granddaddy of them All," but as a player, Hartsock knew there were bigger fish to fry.

"The importance of the Rose Bowl felt to me like something my dad focused on," Hartsock said. "I knew how big it was because I was raised in a house that taught that curriculum, but I transitioned away from it."

When Jim Tressel arrived at Ohio State in 2001, he immediately replaced "Rose Bowl" with "national title."

"When Tressel came in, the main focus was Michigan. It starts with beating Michigan, then winning the Big Ten and the national title," Hartsock said. "And winning the Big Ten was the only way to get to the national title. You could argue thats not the case today."

A team now can fail to win its regular-season conference championship and still win a national title, as Alabama did in 2011 (BCS) and 2017 (College Football Playoff). The playoff selection committee emphasizes that its only mission is to choose the four best teams.

Left unsaid is the reality that any team outside the top four and any bowl outside the two semifinals and championship game becomes an afterthought.

Its now all about making the playoff. Ohio State coach Urban Meyer in 2014 even gave a name to the quest: The Chase.

That doesnt mean coaches minimize conference championships. Meyer stressed in 2014 that "we wake up every day to compete for championships in November." But those conference titles are more a means to an end than the ultimate goal. In Ohio States case, the first job is to win the Big Ten East Division, which gets you into the conference championship game, then win in Indianapolis to hopefully earn a playoff berth.

As for the players, todays Buckeyes are more aware of the drive for a national championship than their predecessors. With 24/7 sports media, tuning out the playoff noise is impossible.

Of course, some things never change, no matter the ultimate goal.

In early August, when the Big Ten was adjusting its schedules to eliminate nonconference games during the coronavirus pandemic, OSU quarterback Justin Fields tweeted, "I dont care when we play Michigan, I just want to play them and beat the brakes off them."

roller@dispatch.com

@rollerCD

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Anatomy of a powerhouse: Expectations at Ohio State now go beyond the Big Ten and Rose Bowl - Suburbanite

Anatomy of . . . Tottenham’s double World Cup winner Alex Morgan – The Times

Age 31Height 5ft 7inClub Tottenham HotspurNationality AmericanTwitter followers 3.9 millionInstagram followers 9.2 million

Team honoursWomens World Cup 2015, 2019SheBelieves Cup 2016, 2018Champions League 2017Olympic gold 2012

Individual honoursSheBelieves Cup Golden Ball and Golden Boot 2016US Soccer athlete of the year 2012, 2018ESPY Award Best female athlete 2019

GaitAt the beginning of Morgans career, team-mates nicknamed her Baby Horse, a name derived from her youth and equine-like gait. Years later her USA team-mate Megan Rapinoe would describe her as full-on stallion. Morgan has turned into a complete striker, equally capable of outmuscling and out-thinking her opponents

DietAfter winning the World Cup with the USA in the summer of 2019, as

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Anatomy of . . . Tottenham's double World Cup winner Alex Morgan - The Times

Grey’s Anatomy and Station 19 Prepare for Another Crossover Event in This Exclusive Teaser Trailer – TV Guide

Grey's Anatomywill be returning on the same night as Station 19 with a two-hour premiere and an epic crossover event on Thursday, Nov. 12, and TV Guide has an exclusive teaser of these COVID-19 episodes. Respective series stars Ellen Pompeo and Jaina Lee Ortiz provide the voiceover for the teaser trailer that will officially premiere Sunday night during the 72nd Primetime Emmy Awards. While there's no new footage from the respective shows in the clip, the actresses emphasize how doctors and first responders have been on the front lines of the pandemic and tease, "Sometimes, we all need saving," which is the tagline for Grey's Anatomy Season 17. It sounds like we need to be worried.

When we last left off with both crews, Andy (Ortiz) had just found out on Station 19 that her mom hadn't actually died when she was a little girl, but had instead left her and her father. Meanwhile on Grey's, Meredith had managed to save Richard (James Pickens Jr.) thanks to a miraculous last-minute diagnosis from DeLuca (Giacomo Gianniotti), but it spurred him to admit something was wrong. That's not to mention all the Teddy (Kim Raver) and Owen (Kevin McKidd) drama... We have a lot to figure out when these shows return. Luckily, it's only a few weeks away!

The Station 19 and Grey's Anatomy crossover event begins Thursday, Nov. 12 at 8/7c.

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Grey's Anatomy and Station 19 Prepare for Another Crossover Event in This Exclusive Teaser Trailer - TV Guide

Anatomy of the New Supercapacitor Industry Revealed by IDTechEx Research – PRNewswire

BOSTON, Sept. 17, 2020 /PRNewswire/ -- Surprises abound in the new IDTechEx Research report, "Supercapacitor Markets, Technology Roadmap, Opportunities 2021-2041". In 2010, there were no Chinese manufacturers in the top ten supercapacitor manufacturers. In 2020, 40% of them are Chinese. This has been achieved by world-class R&D, being in one of the largest markets globally, strong investment and government support including protective trading. However, China is not leading in capacitor-supercapacitor hybrids where the USA saw a $7 million follow on order recently.

Raghu Das, CEO of IDTechEx advises, "Supercapacitor manufacturers used to be divided into those making small ones for electronics and those that also made similar flat or cylindrical formats for electrical engineering such as the archetypal 2.7V 3000F cylinder. No longer. A considerable market for even large supercapacitors is rapidly emerging. The first big success with large ones is boxed car stop-starters at around 20Wh, with over five million sold. The number of automakers going for that fit-and-forget, grab more electricity, waste less electricity proposition still increases. The natural extension of this logic is the newly committed adoption of larger supercapacitors for peak-shaving and acceleration boosting at 30-100Wh across the batteries in mild hybrid cars then full hybrid then totally replacing the lithium-ion battery if pure electric cars have not destroyed the hybrid car business by then."

The new large versions appear in trains at 1kWh and 1MWh appears as hospital and data center uninterruptable power supplies that double for peak shaving. It is a long way from small supercapacitors usually made to standards, easy to make and mostly commoditized at prices of 1 cent/F or less. IDTechEx counts 89% of supercapacitor manufacturers making them though Panasonic recently exited. 37% of these are in China because it exports them strongly, its share of the supercapacitor value demand being only 27% because of its giveaway pricing and lateness into car stop-start.

An exception to the commoditization is small supercapacitors in the form of battery-supercapacitor hybrids BSH, aerospace and military ones working at 150C, capacitor-supercapacitor hybrids beating tantalum electrolytics on ripple and one fifth to one tenth of the size and weight and ones in odd formats such as to go in a watch or smart card. Those working at 85C, -40C and 3V as single cells are less common and in demand.

Battery-supercapacitor hybrids (BSH) are almost always lithium-ion capacitors. They offer higher energy density often with effectively infinite cycle life and better charge retention than pure supercapacitors. Energy density several times that of pure EDLC supercapacitors. There is almost always confined to small units for electronics. IDTechEx measures that 24% of supercapacitor manufacturers now have a BSH range and of those 32% are made in China, where they are most successful commercially. China leads the world here, partly because they have so many large BSHs.

Several companies declare their supercapacitors to be "graphene" as a badge of honor. It can mean non-flammable, relatively non-toxic, no use of the volatile, toxic carcinogen acetonitrile, valuably improved series resistance, better voltage and energy density in a pure EDLC all good things justifying a higher price.

Raghu Das adds, "IDTechEx measures that 8.75% of supercapacitor manufacturers now offer graphene versions, up from zero ten years ago. 43% of the manufacturers using graphene are in China so they are ahead in numbers, though certainly not in graphene supercapacitor research, much of which is aimed at the massive emerging market for replacing lithium-ion and lead-acid batteries with highest energy density of 100Wh/kg or more. In research, this is usually achieved by boosted pseudocapacitance though some perfect the technology of the newly commercial 100 Wh/kg lithium-ion supercapacitors. 33% of supercapacitor material research graphene-centric followed by carbon nanotubes then metal organic frameworks."

Large supercapacitors are more difficult to make, more profitable and represent the majority of the addressable market 2021-2041. Unlike small ones, they typically come with integral power electronics for optimal safe operation, microprocessors for intelligent response, often cooling systems. 47.5% of supercapacitor manufacturers now claim to make them, up from few in the past. However, many of those are barely in the business, their web entries being more of a wish list that reality. 34% of these are in China no dominance though it is coming up fast in this respect. This is assisted by the fact that a disproportionate amount of the demand for large supercapacitors is in China with the Government requesting that all parts of trains, buses etc. be made in China. On the other hand, China is badly behind in researching supercapacitor bodywork, smart skin and other radical advances scoped in the IDTechEx Research report, "Supercapacitor Materials and Formats 2020-2040".

Raghu Das predicts, "Acquisitions and mergers will continue. One billion dollar supercapacitor businesses may be created by 2045. If the addressable markets we have analyzed are strongly penetrated, then it will be much earlier. Given past disappointments, our upside forecast currently stands at $7 billion in 2041."

For more information on this report, please visit http://www.IDTechEx.com/supercaps or for the full portfolio of research available from IDTechEx please visit http://www.IDTechEx.com/Research.

IDTechEx guides your strategic business decisions through its Research, Consultancy and Event products, helping you profit from emerging technologies. For more information on IDTechEx Research and Consultancy, contact [emailprotected] or visit http://www.IDTechEx.com.

Media Contact:

Natalie Moreton Digital Marketing Manager [emailprotected] +44(0)1223 812300

SOURCE IDTechEx

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Anatomy of the New Supercapacitor Industry Revealed by IDTechEx Research - PRNewswire

Video: ‘The Devil All the Time’ | Anatomy of a Scene – The New York Times

NARRATOR: Hi, Im Antonio Campos, and Im the director of The Devil All the Time. So were about 2/3 of the way into the movie, were entering the third act. And Arvin has been spying on this preacher and has figured out that he did something to his stepsister. And so he is coming to get revenge. And one of the things I wanted to convey in this scene is that Arvin isnt a killer. He comes in with the intent of killing him, and in the moment when hes going to shoot, he gets nervous and he sits down, and hes got to muster up the courage to go through with the act. Hes a violent kid, but hes not a killer yet. And so what I wanted to do is I wanted to try and give you two perspectives in this scene, one from the perspective of Teagardin talking to this young man thats come in. You got time for a sinner? Who wants to confess, get something off his chest, and the other, in close up on Arvins face, where we are with Arvin, where were with him, were seeing that hes nervous, and that hes a little anxious. Ive done lustful acts. So we get this angle here, this close-up angle, and thats where were in it with him, and we get to see into his eyes. And then theres the frontal angle, and the frontal, were withholding his eyes. Were seeing it the way that Teagardin sees him. The other thing there is this little technical thing is Teagardin has seen Arvin in church with his grandmother and with his stepsister, but with his hat on, and the angle that hes looking at him, he cant quite identify him. So thats the other reason why this wardrobe was really important for the scene. This is, by far, my favorite scene in the whole movie. And I was so excited for these two characters to come together. And for this force of good and this force of evil to finally meet. And its the beginning of what becomes Arvin coming up against a lot of different evil forces in the story. Its a very long scene, so we really wanted you to feel every single beat. And so this scene took about I think we edited this scene on and off for about nine months. One day I got this girl in my truck and I drove her out to the sticks, and I had my way with her. [SIGHS] She put up a fight? No. And it was really about trying to capture every single detail that these two great actors gave us. I really think that Tom Holland is the greatest actor of his generation. And I think hes so natural, and he conveys such a wonderful humanity, but still manages to capture this kind of danger. And that Rob Pattinson is this kind of mad genius, and you dont know what hes going to give you on the day. And so I had this wonderful footage to work with. And it was really about trying to nail every little micro expression, every gesture. And by doing that, we create this kind of we start building up the tension to the point where then Arvin stands up and, with standing up, he reveals his eyes and reveals his identity to Teagardin. Ive been watching your every move for the last couple weeks. You cant get enough of that Reaster girl, can you? Is that how you did my Lenora, too? And this kind of face off, here, was really this is where it kind of, like, really finely tuned the editing to make sure that every little gesture, once the gun revealed itself, is dangerous for Teagardin. Dont do anything youll regret, son. Why dont you put the gun down, and we can talk all about it? So we really wanted to highlight each beat, and feel every time that Tom gets worked up and Teagardin gets scared. In the sound design, here, you really hear the rattle of the gun. It was just like this this Reaster girl. You get the shake of Arvins hand through the sound of the gun rattling, which is one of these things that we didnt plan on, but when we got into the mix, you really kind of you realize you needed a sound to convey that sort of nervousness, to heighten the nervousness. soul too? Look, I I didnt have nothing to do with that. And then you get this sort of, like, this anger building up. So now Arvin, who came into the scene so, so nervous to go through with the act, is now getting angrier and angrier and angrier. And hes building up the courage to either shoot or not shoot. We dont know yet. We dont know if hes going to change his mind, if Teagardins going to manage to talk his way out of it. I aint going to take the blame for no bastard child. It would ruin me, man. My wife is the editor, Sophia Subercaseaux. She and I always loved every one of Robs deliveries here. She was delusional. Shes crazy. Thats it. Or she was just lonely.

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Video: 'The Devil All the Time' | Anatomy of a Scene - The New York Times

X-Men Anatomy: The 5 Weirdest Things About Storm’s Body, Explained – CBR – Comic Book Resources

Marvel's iconic X-Men leader Storm is an Omega-Level mutant, and she can do so much more with her weather-controlling powers making it rain.

To put it mildly, X-Men comics have a tendency to make the backstories of Marvel's mutants intricately complicated, with multiple points that hinge on odd points of continuity and twists of fate. Decades of story twists and turns compound with sci-fi and fantasy mythology to make characters far more deeply complex than you might imagine, and there's no better example of that than Ororo Monroe, the weather-controlling mutant and X-Men leader known as Storm.

While she might just appear to have some control over localized weather patterns, Storm has evolved into a far deeper, stranger character since she was created by Len Wein and Dave Cockrum in 1975's Giant-Size X-Men #1, and her powers have changed along with her.

RELATED:A Powerful X-Men Villain Has Returned... As A Talk Show Host!?

Storm's ability to control the weather is certainly considerable, and it usually puts her in the top tier of most any given X-Men squad she serves on. Controlling all of that power can be difficult, but aiding her in the task is an extension of her mutant abilities that is not quite as obvious as hurling lightning or whipping up rainstorms: she feels an almost spiritual connection with the planet and its weather cycles, physically perceiving them as energy patterns.

Storm's senses allow her to predict the weather even when she does not influence it and sense any abnormalities in its rhythm. This can have the side effect of inflicting discomfort on her when the Earth is in pain, but she never views her connection as a hindrance. Her claustrophobia is in part so traumatic because it cuts her off from the world around her, so it's understandable why losing such a connection would be anxiety-inducing.

Even with her connection to the planet, Storm's powers don't just work exclusively on Earth. Her powers have been accessible on other worlds, in the vacuum of space and even on the astral plane. The environment very seldom negates Storm's capacity to produce weather phenomena on a whim, although it can prove a limiting factor where she is not as powerful as usual.

This means that Storm maintains her ability to hurl lightning even while underground or to create billowing rainstorms within the constricted confines of an indoor environment. She frequently makes storm clouds just small enough to water her plants, a convenient trick for an avid gardener like Ororo.

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X-Men Anatomy: The 5 Weirdest Things About Storm's Body, Explained - CBR - Comic Book Resources

Anatomy of a record handle year at Scioto Downs – Harness Racing Update

How the rookie team of Joe Morris, Jason Roth and Gabe Prewitt helped post a record handle of $55.3 million at the Columbus, OH track an increase of more than $35 million (and 184 per cent) from 2019.

by Bob Roberts

It almost figures. In a year in which only a sprinkling of fans were on hand to watch the Hambletonian and none will be allowed to take in the Little Brown Jug, another track in central Ohio first with no fans in the stands and then with just a handful of them shattered every wagering record in its 62-year history.

Until this spring, the futuristic-looking Scioto Downs, which opened in 1959 and lost a photo-finish to the St. Lawrence Seaway as a nominee for Outstanding Civil Engineering Achievement, has been a perennial also-ran in the race for North American simulcast dollars.

That all changed when the first-year team of senior vice-president of racing Joe Morris, racing secretary Jason Roth and director of racing Gabe Prewitt put their heads together and turned Scioto Downs into a major player in the signal export business.

In 2019, Scioto Downs totaled $19.5 million in wagering dollars over 90 race dates for an average of $216,666 a program.

This year, it took in $55.3 million over 82 days and nights of betting for an average of $674,390.What made for such a dramatic increase?

Were a new team and we went through things and tried to do whats best for the horsemen and the horseplayer, said Prewitt. Of course, we were lucky to get the jump on the competition.

Scioto Downs COVID-19-delayed opening on May 22 made the south Columbus oval the first track in North America to welcome back pari-mutuel racing.

It allowed us to get our product out there, especially to people that had not previous seen Scioto racing, said Prewitt. It also helped that everybody wanted to enter and race with us. We had a seven to 10 day jump on the competition.

Scioto Downs took full advantage of their calendar advantage by opening with 12 consecutive handles of over $1 million.

Prewitt employed another and rather unique yardstick for measuring success.

I knew we were making an impact when I heard 15 different pronunciations of Scioto the first week of the meeting. There were a lot of new players.

He said that in Morris giving him the green light to try new things, and with Roth putting together attractive racing cards that bettors embraced, the season was off and pacing.

Gabe is a bright guy, Morris told Harness Racing Update. Hes already established a substantial audience for our racing product.

Prewitt focused on managing post times, constructing a wagering menu that attracted fire power, and staying on top of social media.

Scioto Downs kicked off the season with free past performances and live video on its website, as well as placing some of its races on the TVG network.

When the first weekend of racing was over, Scioto had posted its second, third and fourth highest handles in track history.

We revamped the betting menu, completely. We created several carryover opportunities for players, said Prewitt. And my thing is the scheduling of races. Its very important to get your races in the right spots.

Prewitt said he would position himself in a room he called the dungeon (actually the basement tote room) where he would monitor the signals from up to 12 different tracks.

I did everything I could to stay off major signals, he said. I was always looking for a good spot for us, even thinking three or four races down the card. Its like playing poker every night. Youre zigging and zagging to position your races. I learned by watching Dave Bianconi (vice-president of racing at Northfield Park). Hes the best at it.

Sciotos all-time single card betting record ($1.2 million in 1996) fell twice this past season, first with a handle of $1.6 million on May 28, and then $2.09 million seven days later. On the year, there were 15 $1 million handles.

The season was so great that it took Scioto Downs only 17 programs to top the $19.5 million it collected in wagers in all of 2019.

Prewitt pounded the Twitter world each racing night when betting updates and carryover teasers under the banner of #Senditin Army.

He also paired with track announcer Barry Vicroy to handicap the races, not only giving selections, pointing out hot (or cold) drivers and trainers, and studying the odds board for underlays and overlays.

We tried to add to the broadcast, offering horseplayers what they couldnt find on the program pages, said Prewitt. Barry has been around long time. He knows Scioto and its horsemen.

Prewitt knows the pressure will be on next year to maintain or increase Scioto Downs numbers.

Hopefully, well have a few tricks up our sleeves, he said. I think we should do a half-million every time we turn on the lights and race. So, if we race 90 nights, thats a $45 million. And well build on it from there, as we grow the brand.

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Anatomy of a record handle year at Scioto Downs - Harness Racing Update

Forget the GreeksIs This the World’s Oldest Anatomical Text? – Daily Beast

If you were to take a class on anatomy in med school you would probably be told that the history of anatomy really begins in the Renaissance, when doctors and other luminaries like Leonardo da Vinci first started dissecting human bodies and documenting their findings. You might also learn that prior to this point, doctors worked with the anatomical theories of the ancient Greeks and Romans, whose knowledge was gleaned mostly from the bodies of animals and external observation. The ancient Egyptians, who are well known for cutting up dead bodies, might get a look in, but that would likely be it.

But, now, a new study claims that an ancient manuscript unearthed in a tomb in Southern China may well be the worlds oldest anatomical atlas. The article not only promises to revolutionize our understanding of the history of medicine, it also sheds light on the history and scientific foundations of acupuncture.

In an article inThe Anatomical Record, Vivien Shaw and Isabelle Winder of Bangor University, UK, and Rui Diogo of Howard University published their findings about the Mawangdui manuscripts, a collection of philosophical and medical texts from Changsha in the Hunan province of South Central China. The texts are written on silk and were placed in the tomb of Chancellor Li Cang and his family before it was sealed in 168 BCE. They were rediscovered in the 1970s, but the previously unknown medical texts were somewhat overshadowed by the presence of other important discoveries, like the oldest copy of the I Ching. Because of this, Shaw, Winder, and Diogo are the first to treat these medical texts as evidence of ancient anatomy.

The Mawangduitexts, the authors argue, were written in the second-third century BCE and are roughly contemporaneous with now-lost Greek dissection-based anatomical texts. Of course, the approach taken in these Chinese texts is very different than the one we see in their Greek counterparts. Vivien Shaw said, they looked at the body from the viewpoint of traditional Chinese Medicine, which is based on the philosophical concept of complementary opposites of yin and yang, familiar to those in the west who follow eastern spiritualism.

The Mawangduitexts organize the body into eleven pathways, each of which has particular kinds of disease associated with it. Some of these, Isabel Winder said, map onto later acupuncture meridians, even though acupuncture and acupuncture points are nowhere mentioned. Historians had some evidence for the acupuncture meridians from other ancient Chinese texts, but those texts date to the third century CE and are, thus, roughly four hundred years younger than the ones from Mawangdui.

Their findings, said Shaw, not only re-write a key part of Chinese history and affirm that the Han dynasty was a period of widespread intellectual growth, they also provide medical foundations for acupuncture and change our understanding of how it originally worked.

We believe, she said, that our interpretation of the text challenges the widespread belief that there is no scientific foundation for the anatomy of acupuncture, by showing that the earliest physicians writing about meridians were in fact describing the physical body. Modern acupuncture, Shaw added, is grounded in the belief that it is the function of the meridian points thats important. Originally, however, it seems that Chinese anatomists were interested in mapping the structure of the body. In other words, and regardless of whether or not we think these descriptions of the body are accurate, they are scientific. This means that acupuncture, which is often dismissed as more spiritual than scientific, is grounded in a carefully worked out ancient map of the body that was based on scientific observation.

The reason that the Mawangdui texts have been overlooked as an anatomical resource is because they date from a period when the principles of Confucianism were very much in vogue. Han-era China was governed by Confucian law, which maintained stability and structure through the maintenance of a rigid social structure. One element of this social hierarchy was what is called filial piety, in which children must respect and honor their parents. Venerating ones ancestors did not include cutting up your dead parents. As Isabel Winder, one of the authors of the article, said Confucian cultural practices shunned dissection. However, [the evidence leads us to conclude] that dissection was involved and that the authors [of these texts] would have had access to the bodies of criminals.

This brings us to one of the grizzly secrets of the study of anatomy: to be any good at it you have to be examining actual human bodies. At the time, this was not just a Chinese practice. Herophilus of Chalcedon and his younger contemporary Erasistratus of Ceos, Greek-speaking doctors and medical authors working in Alexandria, Egypt in the first half of the third century BCE, were also dissecting cadavers on a routine basis. As in China (and, later, in 16th 19th century Britain), the bodies used for these experiments were those of criminals. Shortly after Herophilus and Erasistratus died, however, dissection fell into disuse. Though there were some rogue doctors who seem to have been dissecting bodies on the sly it wasnt until the 14th century, when the Italian Mondino de Luzzi publicly performed the first sanctioned dissection in a millennium, that it would begin again in earnest.

While dissection vastly improved medical sciences understanding of the workings of the human body, this doesnt mean that those performing these experiments always accurately described what was in front of them. Leonardo da Vincis scientific drawings of the human body are widely admired for their accuracy, but he sometimes followed tradition rather than the evidence, depicting, as Roy Porter has written in his book The Greatest Benefit to Mankind, a five lobed liver. The human liver only has four lobes; the five-lobe theory was based on the dissection of dogs and pigs and goes back to Hippocrates. We should not assume, therefore, that dissection always deepens and improves medical understanding. It took two hundred years and the creative vision of 16th century anatomist Andreas Vesalius for many ancient medical theories to be questioned and revised.

In between the 3rd century BCE and the rediscovery of dissection in the 14th, European doctors were reliant on the works of famous Greek-speaking doctors Aristotle and Galen, who had only dissected animals. Galen had experience treating gladiators and would have seen the kinds of wounds that would have afforded the opportunity peek inside the body, but there was nothing exhaustive about his exploration of the human body. As a result, all kinds of errorsthe five-lobed liver sketched by Da Vinci, for examplecrept into Western medicine. So, if youre thinking that Chinese medicine sounds unscientific and esoteric, bear in mind that for this 1200-year period of European history you may as well have been seeing a vet.

One of the major contributions of this study is the way that it challenges Eurocentric histories of science and medicine. Rui Diogo, whose lab helped perform the research, told The Daily Beast, that too often textbooks and scientific publications rehearse narratives in which white Europeans (from the Greeks and Romans onwards) make the big discoveries and non-European cultures contribute nothing more than translations of Greek texts or esoteric unscientific knowledge. Discoveries like this one show both that there was a vibrant scientific culture in places like India, China, and Persia and also that medical schemes often dismissed as esoteric have real scientific foundations.

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Forget the GreeksIs This the World's Oldest Anatomical Text? - Daily Beast