Mapping the terra incognita of our brains – Pursuit

The most evolutionarily ancient part of our brain is the part that we know the least about.

The human subcortex is located deep in the brains centre and processes everything from our basic senses to long-term memories.

Dysfunction of the subcortex is associated with numerous brain and mental health disorders, including Huntingtons and Parkinsons diseases, schizophrenia and depression.

Our new research, published in Nature Neuroscience, unveils a new brain atlas of the human subcortex, revealing an astoundingly complex hierarchical structure and 27 new subcortical regions.

Brain cartography is the age-old science of map-making for the brain.

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Since the 19th century, brain cartographers have mostly focussed on mapping the territories, regions and networks of the outermost layer of the human brain, known as the cerebral cortex.

This has left the subcortex as an uncharted terra incognita.

As a result of this scarcity of subcortical atlases, many attempts to derive a wiring diagram for the brain, known as the human connectome, often exclude the subcortex.

Furthermore, selecting the best location for focal therapies targeting the subcortex like deep brain stimulation (DBS) requires detailed subcortical atlases to enable accurate targeting.

This involves implanting electrodes into a patients brain and electrically stimulating subcortical targets to treat the symptoms of Parkinsons disease, epilepsy and several neuropsychiatric disorders.

Identifying stimulation targets can be challenging without an atlas.

Our team used high-resolution functional magnetic resonance imaging (MRI) scans of more than 1000 people to map the most detailed subcortical atlas to date.

Our research team discovered 27 new territories of the human subcortex, each demarcated by distinct borders and associated with a distinct function.

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But our new atlas reveals an astoundingly complex organisational architecture that stretches across four hierarchical levels.

Amazingly, the borders separating some of the areas shifted when people were asked to engage in cognitively demanding tasks during the brain scan.

It means that these territories and regions of the subcortex are dynamic and can reorganise depending on an individuals actions and thoughts.

The new atlas represents several years of work to map the functional areas of one of the remaining unchartered territories of the human brain.

The atlas, which was made possible by the high-quality brain scans provided by the Human Connectome Project, was initially mapped using brain scans from a 3 Tesla MRI scanner this is the type of scanner typically found in most hospital radiology departments.

Our research used a high-field strength 7 Tesla scanner to reproduce the atlas revealing new areas in unprecedented detail.

Crucially, the subcortical atlas provides neuroscientists with new opportunities to study the function of the brains subcortex in health and disease.

Just as atlases of the world were vital to the circumnavigators of the past, atlases of the brain are also vital to neurosurgeons navigating the subcortex to implant electrodes for deep brain stimulation (DBS) and other targeted treatments.

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Whereas circumnavigators relied on sextants and hand-drawn maps, modern brain cartography utilises brain MRI scans and advanced computational techniques.

That said, the basic principles are more or less the same and involve drawing boundaries at locations of abrupt change in brain structure and patterns of connectivity.

The unprecedented resolution of the new subcortical atlas can assist delivery of targeted treatments to highly specific subcortical territories.

The atlas is currently used to identify treatment targets in our ongoing clinical trial of a novel transcranial magnetic stimulation (TMS) therapy for obsessive-compulsive disorder (OCD).

OCD is associated with brain changes in a key region of our atlas that is called the striatum, and so we aim to target TMS therapy to cortical regions that are strongly connected to this region.

Without an accurate map, targeting of TMS and other precision therapies can be challenging, if not impossible.

Notably, the subcortex is the brains central gatekeeper, modulating input and output information between the outer layers of the brain and the rest of the body.

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Our atlas reveals how specific regions and territories of the subcortex are connected to the rest of the brain and form brain-wide networks that orchestrate everything from cognitive function to sensory and motor processing.

While the subcortex is spatially distant from the outer layers of the brain, we found that each of the 27 newly-discovered subcortical territories display patterns of activity that are highly synchronised with specific parts of the cerebral cortex.

It demonstrates the extent to which different parts of the brain are interconnected to form networks.

Our new atlas maps an important and previously unchartered part of the human brain in unprecedented detail, but it also reveals just how much we have yet to learn about the complexities of our brains.

Banner: Erasmus Wilson/Wellcome Trust

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Mapping the terra incognita of our brains - Pursuit

Brain Machine Interfaces and Neuromodulation Market will touch a new level in upcoming year with Top Key Players like Advanced Bionics, Advanced Brain…

Brain Machine Interfaces and Neuromodulation Market research is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Brain Machine Interfaces and Neuromodulation Market is growing at a High CAGR during the forecast period 2020-2026. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

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Advanced Bionics, Advanced Brain Monitoring, BIOS, Bitbrain, BrainCo, Cochlear Limited, Cognixion, Dreem, Emotiv, Flow Neuroscience, Halo Neuroscience, InteraXon, MED-EL, Neurable, Neuralink, NeuroPace, Neuros Medical, NeuroSky, Nextmind, Paradromics, Synchron, Thync, Versus

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Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Brain Machine Interfaces and Neuromodulation market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Brain Machine Interfaces and Neuromodulation markets trajectory between forecast periods.

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Global Brain Machine Interfaces and Neuromodulation Market Research Report 2020 2026

Chapter 1 Brain Machine Interfaces and Neuromodulation Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Brain Machine Interfaces and Neuromodulation Market Forecast

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Area 32 How the Brain Balances Emotion and Reason – SciTechDaily

Area 32 balances activity from cognitive and emotional brain areas in primates.

Navigating through life requires balancing emotion and reason, a feat accomplished by the brain region area 32 of the anterior cingulate cortex. The area maintains emotional equilibrium by relaying information between cognitive and emotional brain regions, according to new research in monkeys published inJNeurosci.

Emotional balance goes haywire in mood disorders like depression, leading to unchecked negative emotions and an inability to break out of rumination. In fact, people with depression often have an overactive area 25, a region involved in emotional expression. Healthy emotional regulation requires communication between cognitive regions, like the dorsolateral prefrontal cortex (DLPFC), and emotion regions, like area 25, also known as the subgenual cortex. But because these two areas are weakly connected, there must be a middleman involved.

Superficial layer neurons from the DLPFC send feedforward projections to the deep layers of A32. A32 sends projections to A25 originating in superficial and deep layers of A32. By predominantly targeting disinhibitory neurons in the superficial layers, pathways from A32 to the superficial layers of A25 may allow excitatory signals to propagate through the local circuitry. By predominantly targeting PV neurons in the deep layers, A32 engages a stronger inhibitory system and likely has a stronger ability to dampen activity in the local circuitry. Credit: Joyce et al., JNeurosci 2020

Joyce et al. used bidirectional neuron tracers to visualize the connections between the DLPFC, area 25, and area 32, a potential middleman, in rhesus monkeys. The DLPFC connects to the deepest layers of area 32, where the strongest inhibitory neurons reside. Area 32 connects to every layer of area 25, positioning it as a powerful regulator of area 25 activity. In healthy brains, the DLPFC signals to area 32 to balance area 25 activity, allowing emotional equilibrium. But in depression, silence from the DLPFC results in too much area 25 activity and out-of-control emotional processing.

Reference: Serial Prefrontal Pathways Are Positioned To Balance Cognition and Emotion in Primates 28 September 2020, Journal of Neuroscience.DOI: 10.1523/JNEUROSCI.0860-20.2020

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Area 32 How the Brain Balances Emotion and Reason - SciTechDaily

COVID-19 Ushers in the Future of Conferences – The Scientist

The Society for Mathematical Biology and the European Society for Mathematical and Theoretical Biology had planned to hold a joint conference this August in Heidelberg, Germany. But by the time spring rolled around, and the pandemic took firm hold of global travel, that was looking less and less likely. On May 9, the organizers postponed the in-person meeting until 2021. Amber Smith, a mathematical biologist at the University of Tennessee Health Science Center, and her fellow conference organizers stepped in to put together a virtual conference to give researchers a chance to share the research still advancing worldwide.

We were really trying to have a meeting that was as close to an in-person meeting as we could possibly have, Smith tells The Scientist. They found Sococo, a platform that allows users to create an online building. The organizers worked closely with virtual event coordinators at MathDept.org to design the Sococo virtual space so it would provide for socializing, networking, and mentoring, as well as hearing talks, seeing posters, and visiting the meetings corporate sponsors.

The goal, according to Smith, was to build an experience that was more than sitting on a Zoom call watching talk after talk. Participants, represented by little colored dots, entered a room by clicking on it and socialized using a feature that finds and pings colleagues for a video chat within the Sococo platform. Via Zoom and webinar integration, all the people in a virtual presentation space attended the same talks and could ask questions by chat, audio, or video.

We got a ton of feedback from people saying that they absolutely loved it, Smith says. Plus, the roughly 1,800 attendees represented more than 90 different countriestwo to three times as many as at previous in-person Society for Mathematical Biology meetings. The organizers plan to incorporate some virtual components into future conferences, even post-pandemic, she adds.

If we could do it for coronavirus, then we can do it for the climate crisis, too.

Abraham Palmer, University of California, San Diego

Plenty of meetings have gone virtualor been canceled all togethersince the beginning of the COVID-19 pandemic. Proponents of online conferences point to reduced carbon emissions and increased accessibility as they make the case for making many of the pandemic-induced changes to meetings permanent. It remains to be seen whether connections made online will support science in the same way as those made in person, but researchers around the world are trying out strategies to make virtual interactions a success.

Even before the pandemic forced the issue, scientists had been thinking about ways to reduce their carbon footprints, often by cutting back on air travel.

Between the record number of hurricanes in the Atlantic and fires in the western US, there is an urgent climate emergency, Abraham Palmer, a geneticist at the University of California, San Diego, tells The Scientist. He and Chloe Jordan of the National Institute on Drug Abuse wrote an editorial published on September 16 touting the climate benefits of virtual meetings and exhorting scientists to act. In a comment published August 13, Palmer and Jordan describe how well an online planning meeting for the annual American College of Neuropsychopharmacology conference worked, while detailing the high costboth in finances and CO2 emissionsof flying everyone to previous planning sessions.

Participants video chatting in the Sococo platform at the Society for Mathematical Biology meeting held online in August

AMBER SMITH

Meeting online, whether its for a conference, study section, or worldwide lab gathering, works better than people expect, and its more convenient and economical, Palmer says. When colleagues talk about missing the in-person stuffdinners, drinks, and chance meetings when sharing a cab to or from an airporthe reminds them of the climate, financial, and time burden of all of those things that theyre missing and of the benefits of changing things up.

I really do hope that were going to look back in five or ten years and this will really have been a turning point where a lot of the things that we had leading up to COVID are never going to get rebuilt the same way they were, he says. If we could do it for coronavirus, then we can do it for the climate crisis, too.

Another benefit of meeting virtually is how many more people can access the conferences. Researchers with caregiving responsibilities, disabilities, travel restrictions, scheduling conflicts, or limited funds are more likely to be able to attend a meeting online, says Sarvenaz Sarabipour, a computational biologist at Johns Hopkins University. She and an international group of other early-career researchers posted a preprint on bioRxiv in April in which they curated a database of more than 270 past in-person conferences across scientific disciplines and evaluated them for inclusivity and sustainability.

They found that nearly 860,000 people spent more than $1.288 billion and generated upwards of 2 million tons of CO2 attending these conferences between 2016 and 2020. And for the most part, the gatherings had no public diversity or gender equity policies and didnt offer childcare or formal accommodations for nursing a baby. The authors propose several alternatives, including taking things online and putting emphasis on regional conferences or coordinating several hubs of one larger conference, so less air travel would be required to attend, an idea that Palmer favors as well.

One of the main objections that people make to virtual meetings is the loss of networking time, especially for early-career researchers looking for jobs. That criticism is unfounded, according to Sarabipour, who says that the websites of scientific journals, Twitter, and, more recently, massive Slack communities of early-career scientists have been more consistent sources for jobseekers than once-yearly scientific meetings. And despite the objections, the widespread adoption of online interactions during the pandemic begs the question of why we had to get to this point to do something this good. Sarabipour says.

Even before the pandemic, some researchers were working on making meetings better. Last summer, Dan Goodman, a computational neuroscientist at Imperial College London, was involved in discussions with various colleagues about how to reduce the climate impact of conferences. People were saying we should make them online, and I was very skeptical of that, because I understood that the point of conferences is not just to look at the talks, its to meet people and to make new connections, he tells The Scientist. I wasnt really convinced that it would work online.

One of the main objections that people make to virtual meetings is the loss of networking time, especially for early-career researchers looking for jobs.

Then, in September 2019, Goodman headed to the Conference on Cognitive Computational Neuroscience in Berlin, where he participated in a so-called mind matching session. Participants provided three abstracts representative of their research and were matched by an algorithm with up to six other scientists, with whom they had 15-minute conversations.

My mind was absolutely blown by it, because I sat down, and I met six people that Id never met before. Two of them were working on exactly the same problem that I was working on, and Id never heard of them, Goodman says. I thought, Okay, if you have something as powerful as this, maybe you can get rid of in-person conferences because you can replace that social element, which is the point of the whole thing.

Goodman got in touch with University of Pennsylvania computational neuroscientist Konrad Kording and Titipat Achakulvisut, a graduate student in Kordings group who led the development of the algorithm behind the mind matching. It works by analyzing the text supplied by each person, as well as people they already know and people they hope to meet, and using those analyses to create a matrix of compatibility from which they pull possible matches. They use a similar strategy for matching jobseekers with job listings at meetings.

Along with some other colleagues, Goodman, Kording, and Achakulvisut started to plan an online computational neuroscience unconference called neuromatch that, in addition to having live talks via Crowdcast, would offer attendees six suggestions of people to speak to. When things started to shut down due to COVID-19, they quickly planned to hold the first neuromatch in March. It was free, and 3,000 people attended.

In a point-of-view published in eLifein April, the organizers explain their strategies for running the online unconference. In May, they held neuromatch 2.0, also attended by about 3,000 people, and theyre planning neuromatch 3.0 for October. For the first time, at neuromatch 3.0, the organizers are charging a $25 registration fee that anyone can waive, no questions asked, and have opened the unconference to all neuroscientists, not just those interested in computational neuro.

Achakulvisut predicts that both online and in-person conferences will exist in the future, but that many neuromatch attendees will probably keep coming to online conferences. We have people from all over the world that typically cant show up if the conference is somewhere hard to get tobecause of visa restrictions, distance, expense, or something else.

The sort of reach that a conference like neuromatch offers is just the beginning of what Mike Morrison, a web developerturnedMichigan State University PhD student in work psychology, would like to see for science. In a commentary published September 3, he and his coauthors propose that scientific conferences, especially now that so many are taking place virtually, could be venues to update the whole world about the progress of science, not just the attendees.

Making all conference productstalks, posters, and abstractsavailable as YouTube videos, images via FigShare, and preprints, they argue, could be a way to accelerate the pace of discovery by reaching everyone who might possibly contribute. Conference administrators want this bigger impact for their attendees, Morrison says. Im really looking forward to hearing from a scientific conference to see if they want to try it.

Another democratizing strategy Morrison and colleagues propose is the #TwitterPoster, a threetofiveslide PowerPoint presentation optimized to be shared as a GIF on Twittera tool that could also work in poster sessions at virtual meetings. Sharing information in this flipbook-like style was so successful for a group of psychology grad students at University College Dublin earlier this year that their hashtag #GIFsFromYourGaff started trending.

Michigan State University PhD student Mike Morrison introduces the #TwitterPoster, a strategy for sharing science quickly on Twitter.

MIKE MOrrison

On the internet, it is the nature of content to be freely available, spread widely, and permanent, Morrison tells The Scientist. In science, our content is still locked-down, kept to ourselves, andespecially in the case of conference contentephemeral. What I want for the future is for science to close the gap with modern publishing methods, so it can be as available and easy to access as the rest of humanitys content.

The Transforming Vaccinology meeting originally planned for March was canceled, but the organizers and facilitating nonprofit Keystone Symposia regrouped to offer a COVID-19specific vaccinology conference online in June. In the context of a pandemic, it was perhaps even more critical to have so many researchersincluding keynote speaker Anthony Fauci, director of the National Institute of Allergy and Infectious Diseasesable to come together and trade ideas.

The meeting got tremendous interest, and a lot of unpublished data was shared, says Thale Jarvis, Keystone Symposias chief scientific officer. The organizers commented on the amazing . . . democratization of the access to science.

Participants from more than 60 countries engaged in extensive Q&A sessions with speakers via chat and video, and session moderators moved unanswered questions over to the public forum for further discussion. We have a variety of different ways that we try to try to connect people and, obviously, its never going to quite replicate those random interactions that happen at a face-to-face meeting, where you strike up a conversation on the way over to breakfast and end up discovering you have something in common scientifically, she says, but the sort of kneejerk reaction that because its a virtual format it wont give a satisfying outcome is a bit unfair.

Especially for innovators, being physically close at some point is, as far as the research indicates, pretty important.

Maria Roche, Harvard Business School

Since early in the pandemic, Gautam Dey, a postdoc at University College London, has co-organized an online seminar series called pombeTalks that draws around 150 fission yeast researchers to Zoom every other week. He and organizers of other virtual seminar series published a perspective in the Journal of Cell Science on August 1, giving tips for starting and supporting such a community.

The online formats, whether its a virtual conference format or a seminar series format, are extremely good at broadly disseminating information . . . and to make that as inclusive and effectively carbon neutral as possible, he says. But the thing that I anecdotally observe in those interactions is that they are, with some exceptions, built upon preexisting, real-world relationships between people that have built up over years, he adds. To me, it seems very difficult to de novo generate new scientific connections between people through these virtual formats, whatever they are.

Deys concern is neither uncommon nor unfounded. Maria Roche, who studies knowledge production and innovation at Harvard Business School, tells The Scientist that studies have shown that colocationeven temporary colocation at an in-person conferencecan have an effect on the rate and quality of scientific collaborations. Especially for innovators, being physically close at some point is, as far as the research indicates, pretty important, she says.

Psychologist Anne Frenzel and chronobiologist Martha Merrow, both of Ludwig Maximilian University of Munich, have collaborated to study participant experiences in virtual conferences created to reduce carbon emissions. In the first iteration, some participants gathered at regional hubs to cut down on travel and others participated fully online.

The researchers have been exploring whether conference participants experience different levels of subjective satisfaction of the three basic psychological needs of relatedness (feeling connected with the other conference attendees), competence (feeling capable, effective, and proficient), and autonomy (having a sense of choice) when attending virtual versus live conferences, Frenzel writes in an email to The Scientist.The relatedness factor seems the one which is most at stake with virtual formats.

According to Frenzel, preliminary and poorly statistically powered analyses so far indicate that virtual attendance, as compared to live attendance at the hubs, did not substantially affect psychological experiences of basic need satisfaction. But she cautions that she is reluctant to interpret those findings in a way that suggests virtual conferences work just as well as live conferences from a psychological perspective. Psychological research addressing the impact of digitally-based versus in-person interaction is fairly limited, she adds, but this striking research gap . . . is certainly currently being addressed in many ongoing projects inspired by the COVID crisis.

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COVID-19 Ushers in the Future of Conferences - The Scientist

Want to Decode the Human Brain? There’s a New System for That, and It’s Pretty Wild – Singularity Hub

Even for high-tech California, the man strolling around UCLA was a curious sight.

His motion capture suit, sensor-embedded gloves, and virtual reality eyewear were already enough to turn heads. But what stopped people in their tracks and made them stare was a bizarre headgear, tightly strapped to his head through a swimming cap-like device embedded with circular electrode connectors. Several springy wires sprouted from the headgearpicture a portable hard drive hooked up to a police siren enclosureand disappeared into a backpack. The half-cyborg look teetered between sci-fi futurism and hardware Mad Libs.

Meet Mo-DBRS, a setup that could fundamentally change how we decode the human brain.

The entire platform is a technological chimera that synchronizes brain recordings, biomarkers, motion capture, eye tracking, and AR/VR visuals. Most of the processing components are stuffed into a backpack, so that the wearer isnt tethered to a landline computer. Instead, they can freely move around and exploreeither in the real world or in VRsomething not usually possible with brain scanning technology like MRI.

Movement may seem like a trivial addition to brain scanning, but its a game changer. Many of our treasured neural capabilitiesmemory, decision-makingare honed as we explore the world around us. Mo-DBRS provides a window into those brain processes in a natural setting, one where the person isnt told to hold still while a giant magnet clicks and clangs around their head. Despite its non-conventional look, Mo-DBRS opens the door to analyzing brain signals in humans in environments close to the real world, while also having the ability to alter those brain signals wirelessly with a few taps on a tablet.

All custom software powering Mo-DBRS is open-sourced, so neuroscientists can immediately play with and contribute to the platform. However, because the setup relies on volunteers with implanted electrodes into the brain, its currently only tested in a small number of people with epilepsy who already have neural implants to help diagnose and prevent their seizures.

Published in Neuron last week, the response from the neuroscience community on Twitter was a unanimous Wow! Fantastic work, wrote Dr. Michael Okun, Medical Director at the Parkinsons Foundation. Very impressive setup, tweeted Dr. Klaus Gramann, a researcher in mobile brain-body imaging at Technische Universitt Berlin.

Dreamt since grad school of 1-day being able to record from deep brain regions (like hippocampus) in humans during spatial navigation & learning/memory in naturalistic experiences, tweeted lead author Dr. Nanthia Suthana at UCLA. My lab team has made that dream come true!

Mo-DBRS isnt as sleek as Neuralinks brain implant. Its also restricted to people with electrodes already in their brains. So whats the big deal?

Everything. Those sci-fi dreams of restoring memory, reversing paralysis, battling depression, erasing fear, and solving consciousness? They all depend on capturing and understanding the human brains neural codethat is, how do electrical firings turn into memories, emotions, and behavior? Since the beginning of modern neuroscience, this has been done using electrodes implanted into mice or other experimental animals.

Take memory, a brain capability that lays the foundation of who you are.

Until now, memory research has mostly relied on rodents scurrying around mazes looking for tasty treats. Rough translation? Those experiments simulate us finding our cars in a parking lot, and identify the brain waves behind that spatial memory. By recording signals from the mices hippocampi, a seahorse-shaped structure buried deep inside the brain, scientists have set up a framework of how our memory workshow a single experience is tied to a time and space, and how a precious memory is linked to our emotions and reinforced.

The obvious problem? Humans arent mice.

For a brain function as intimate as memory, its incredibly difficult to extrapolate from rodent brain recordings. While traditional brain imaging methods for humans, such as functional MRI (fMRI) or magnetoencephalography (MEG) can paint a stationary image of the brain as it remembers a placeoften played on a video screenthe setup is far from normal in that the person is completely immobile.

Mo-DBRS goes after a whole wish list of brain decoding needs: reading and writing from the human brain in real time, wirelessly, while the person walks around, and combining neural recordings with heart rate, breathing, and other biomarker sensors.

The inspiration came from patients with epilepsy and other neurological disorders who already have electrodes implanted into their brains and go about their normal lives. There are over 2,000 individuals with chronic sensing and stimulation deviceswith the number expected to increase as additional invasive treatments are proven successful, the team wrote. These devices are implanted into deep regions of the brainthose controlling memory, emotion, and movement. With careful planning to avoid interfering with their treatment, the authors reasoned, its possible to tap into these neural recordings to directly decode the human brains activity in a real-life setting, rather than relying on rodent studies or MRI-style immobile brain imaging.

The heart of Mo-DBRSs brain recording and stimulation setup is a medical device called NeuroPace, which is often implanted inside the skull to help epilepsy patients control their seizures. Think of NeuroPace as a pacemaker for the brain. It can both read the brains electrical signals and write into the brainusing short electrical pulses to prevent a seizure electrical storm from occurring. However, like a radio, many brain processes rely on a certain frequency. By skirting the frequencies that help control seizures, the team was able to listen in and control other brain processes, such as electrical signals that form as people explore new environments. Data from the implanted device is wirelessly transferred to a custom-built wand (the weird hard drive-police siren-looking thing) strapped to the outside of the head.

Using a Raspberry PI computer and a tabletboth stored inside a backpackthat are connected to the wand, the team was able to wirelessly program the neural implant to deliver electrical pulses into the brain. At the same time, the team also added scalp EEG, which measures the brains electrical waves through electrodes embedded in a cap thats worn on the head like a swim cap. This technological tag-team provides an explosion of neural data, from both inside and outside the brain.

Moving beyond the brain, the team further equipped volunteers with a chest strap that senses heart rate, breathing, and sweating. These biomarkers capture the emotional responses around a specific memory, which could help better understand how emotionally-charged memories tend to stick around. To synchronize all the data, the team added an artificial marking signala strange-looking electrical patterninto brain recordings to denote the start of an experiment.

The whole system weighs about nine pounds, with most of the processing components tucked inside a backpack. A lighter version weighing about a pound, called Mo-DBRS Lite is also ready to go, the team explained, but comes with the caveat of decreased efficiency on synchronization with a higher delay in reading from the brain.

As a proof-of-concept, Mo-DIBS was tested on seven volunteers already implanted with the NeuroPace system. One person easily walked around a room to look at a wall-mounted sign while having his eyes, brain activity, and other biomarkers tracked without a hitch. Add in a component of VR, and its completely possible to recreate the classic memory experiment of navigating a mazeonly this time, rather than rodents, scientists are recording directly from the human brain, with the potential to disrupt those signals and play with memory.

Although Mo-DBRS is built using NeuroPace, the platform can be integrated with other existing neural implants, the team said. The entire software code is open-sourced for researchers to collaborate and expand on.

Theres a lot of potential here with the platform to start asking questions that we havent been able to do before in neuroscience, because weve been limited by the immobility of our participants, said Suthana. We can start to explore novel therapies that involve neurostimulation and [understand] the neural mechanisms that are involved in these types of treatments.

Image Credit: christitzeimaging.com/Shutterstock.com

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Want to Decode the Human Brain? There's a New System for That, and It's Pretty Wild - Singularity Hub

Physiology of Handcycling: A Current Sports Perspective – DocWire News

This article was originally published here

Scand J Med Sci Sports. 2020 Sep 23. doi: 10.1111/sms.13835. Online ahead of print.

ABSTRACT

Handcycling is a mode of mobility, and sport format within Para-cycling, for those with a lower limb impairment. The exercise modality has been researched extensively in the rehabilitation setting. However, there is an emerging body of evidence detailing the physiological responses to handcycling in the competitive sport domain. Competitive handcyclists utilise equipment that is vastly disparate to that used for rehabilitation or recreation. Furthermore, the transferability of findings from early handcycling research to current international athletes regarding physiological profiles is severely limited. This narrative review aims to map the landscape within handcycling research and document the growing interest at the elite end of the exercise spectrum. From 58 experimental/case studies and four doctoral theses we: provide accounts of the aerobic capacity of handcyclists and the influence training status plays; present research regarding the physiological responses to handcycling performance, including tests of sprint performance; discuss the finite information on handcyclists training habits and efficacy of bespoke interventions. Furthermore, given the wide variety of protocols employed and participants recruited previously, we present considerations for the interpretation of existing research and recommendations for future work, all with a focus on competitive sport. The majority of studies (n=21) reported aerobic capacity, detailing peak rates of oxygen uptake and power output, with values >3.0 Lmin-1 and 240 W shown in trained, male H3-H4 classification athletes. Knowledge, though, is lacking for other classifications and female athletes. Similarly, little research is available concerning sprint performance with only one from eight studies recruiting athletes with an impairment.

PMID:32969103 | DOI:10.1111/sms.13835

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Physiology of Handcycling: A Current Sports Perspective - DocWire News

A Parent’s Touch Can Reduce Pain Signaling in the Baby Brain – Technology Networks

Being held by a parent with skin-to-skin contact reduces how strongly a newborn baby's brain responds to a painful medical jab, finds a new study led by researchers at UCL and York University, Canada.

The scientists report in the European Journal of Pain that there was more activity in the brains of newborn babies in reaction to the pain when a parent was holding them through clothing, than without clothing.

Joint senior author, Dr Lorenzo Fabrizi (UCL Neuroscience, Physiology & Pharmacology) said: "We have found when a baby is held by their parent, with skin-on-skin contact, the higher-level brain processing in response to pain is somewhat dampened. The baby's brain is also using a different pathway to process its response to pain.

"While we cannot confirm whether the baby actually feels less pain, our findings reinforce the important role of touch between parents and their newborn babies."

The study involved 27 infants, 0-96 days old and born premature or at term age, at University College London Hospitals. The researchers were measuring their response to a painful but clinically required heel lance (blood test). Brain activity was recorded with EEG (electroencephalography) electrodes placed on the scalp.

The babies were either held by their mother skin-to-skin (wearing a diaper, against their mother's chest), or held by their mother with clothing, or else lying in a cot or incubator (most of these babies were swaddled).

The researchers found that the initial brain response to the pain was the same, but as the heel lance elicited a series of four to five waves of brain activity, the later waves of activity were impacted by whether the baby was held skin-to-skin or with clothing.

Joint senior author, Professor Rebecca Pillai Riddell (Department of Psychology, York University, Canada) said: "The slightly delayed response was dampened if there was skin contact with their mother, which suggests that parental touch impacts the brain's higher level processing. The pain might be the same, but how the baby's brain processes and reacts to that pain depends on their contact with a parent.

"Our findings support the notion that holding a newborn baby against your skin is important to their development."

The brains of the babies that remained in the cot or incubator also reacted less strongly to the pain than those held in clothing, but the researchers say that may be because the babies were not disrupted by being picked up before the procedure, or else due to the success of the sensitive, individualised care they were provided.

The babies' behaviour was not significantly different between the groups, although the skin-to-skin group did exhibit slightly reduced responses in terms of facial expression and heart rate. Other studies have found that skin-to-skin contact with a parent does affect baby behaviour, and may reduce how strongly they react to pain, but those studies did not investigate the brain response.

In the current study, the babies' brain responses were not only dampened in the skin-to-skin group, but also followed a different neural pathway.

First author, Dr Laura Jones (UCL Neuroscience, Physiology & Pharmacology) said: "Newborn babies' brains have a high degree of plasticity, particularly those born preterm, and their development is highly dependent on interactions with their parents. Our findings may lend new insights into how babies learn to process threats, as they are particularly sensitive to maternal cues."

Co-author Dr Judith Meek (University College London Hospitals) said: "Parents and clinicians have known for many years how important skin to skin care is for babies in NICU. Now we have been able to demonstrate that this has a solid neurophysiological basis, which is an exciting discovery."

Reference: Jones L, LaudianoDray MP, Whitehead K, et al.The impact of parental contact upon cortical noxiousrelated activity in human neonates.Eur J Pain, 2020. doi: 10.1002/ejp.1656

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This is what happens to your body over months in isolation – CNN International

Being homebound for so long contorts the body, weakens the heart and lungs and even impairs brain function. The effects of life in isolation may stay with us beyond the pandemic's end (whenever that may be).

This is what half a year of isolation, staying home and staying sedentary can do to your body.

A week homebound, whether you're working, eating or sleeping, may feel comforting and necessary. But all the inactivity can undo hard-won progress.

That's because it can take months to build muscle and just one week to lose it. Humans, for all of our hardiness, also lose muscle more quickly the older we get, said Keith Baar, a professor of molecular exercise physiology at the University of California - Davis.

When you lose muscle, you're not necessarily losing bulk, but you are losing strength, which Baar said is one of the "strongest indicators" of how long you'll live.

"The stronger we stay, the easier it is for us to maintain our longevity."

If you're not exercising, you're not raising your heart rate. And when your heart isn't pumping as hard, it gets weaker, Baar said.

The same thing happens to your lungs when you're inactive, said Dr. Panagis Galiatsatos, a pulmonologist from Johns Hopkins Bayview Medical Center. He said many of his patients have felt their breathing function deteriorate because they're no longer conditioned to exercise.

People with poor lung health are already considered more susceptible to coronavirus because it's a respiratory illness, so they're likely staying home to reduce their risk of infection. But if they're not moving and increasing blood flow to their lungs, then their preexisting condition might harm them anyway.

Exercise is the only key to improve both heart and lung function -- "Not a single medication can do that," Galiatsatos said. If it's not safe to leave the house, Baar recommends dancing or finding household objects for home strength training -- think milk jug deadlifts.

If you're home all day, every day, you're likely feet away from your pantry. Depending on your perspective, that's either convenient or dangerous.

With such easy access, your "feeding" window, or the period of time during which you eat most of your meals, might widen from 10 or 12 hours every day to 15 hours a day-- more than half the day, which could cause your insulin levels to spike. Insulin encourages fat storage and converting other fat molecules to fat, said Giles Duffield, an associate professor of anatomy and physiology at the University of Notre Dame who studies circadian rhythms and metabolism, among other subjects.

Excessive eating is also an issue because, at the beginning of the pandemic, many people stocked up on nonperishable foods in case of supply shortages, Duffield said. Many nonperishable foods are highly processed and rich in sugars and starches.

Weight gain during periods of intense stress is normal, and 2020 has been unrelentingly stressful. Weight gain becomes dangerous, though, when it turns into obesity. Then, your body might start to resist insulin, and chronic health issues like metabolic illness or diabetes may develop, Duffield said.

We all have a seated position we subconsciously sink into -- slumped forward, shoulders hunched; spine curled, neck bent; on your chest, elbows up.

But sitting and lying down all day can seriously affect your posture and strain your back, neck, shoulders, hips and eyes, said Brandon Brown, an epidemiologist and associate professor in the Center for Healthy Communities at the University of California - Riverside.

Brown suggests getting up from your seat once an hour, walking around and stretching for a moment. You might even lie on the floor and "let your back readjust," he said.

At least half of all Americans are skimping on vitamin D, which sustains bone density and keeps fatigue at bay. You're definitely one of them if you spend most of your day at home, curtains drawn, Duffield said.

Getting enough sunlight in the morning helps synchronize your body's circadian rhythm, Duffield said. So if you're shut in all week or working in the dark, your sleep might suffer, too.

Brown said as long as you're going on walks or exercising, doing yard work or other activities that drag you outside for a bit, you won't need to worry about getting enough sunlight. If you're unable to get out of the house or the weather won't permit you to, an artificial bright light can help your body retune in the morning, Duffield said, as can avoiding blue lights at night.

A sedentary lifestyle can slow your brain, too.

Exercise produces certain chemicals in the brain that break down toxins in the blood and even prevent them from going to the brain, where they can kill brain cells, Baar said.

Not exercising means you won't as efficiently break down amino acid byproducts that wind up as neurotoxins in the brain.

The effects of isolation are insidious -- like the pandemic, the physical symptoms after months of seclusion often aren't obvious until they become harmful or extreme.

It's possible, too, to stave off those symptoms before they set in for good.

Prioritizing your mental and physical health while staying home requires some work, but it's a healthier coping mechanism for uncertainty than staying stationary until Covid-19 is no longer a threat, health experts say. And when it's safe to live fully again, you'll be prepared.

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This is what happens to your body over months in isolation - CNN International

A Conversation With Professor Josef Penninger on the Journey to a COVID-19 Therapeutic – Technology Networks

Professor Josef Penninger. Credit: Paul Joseph for LSI.

Angiotensin-converting enzyme 2 (ACE2) the receptor used by the SARS-CoV-2 virus as a gateway to enter and infect host cells has garnered significant attention for the wrong reasons over recent months. But could it also point towards an exit route out of this pandemic? In an interview with Technology Networks, the renowned immunologist Professor Josef Penninger nicknamed "Mr ACE2" explains why he thinks so, and discusses the latest clinical data obtained from testing the soluble ACE2 receptor, APN01.

Before the Nature paper was published, the researchers discovered that ACE2 was also expressed in the lung, a curious finding which "didn't make any sense".1 They wanted to get to the bottom of it. "All of my postdocs worked on models for intensive care units for mice so that we could study acute lung injury. At that time, between 20002003, there were maybe two or three groups on the planet which did this. The reason being it was difficult to create stable and reproducible models. My postdocs worked for many years to get the model going and then we studied ACE2 using it. We found that when we delete ACE2 in animal models the lung injury got much worse. The reninangiotensin unit is a critical component of lung injury."2

What role does ACE2 play in the body?In 2020, thanks to the contribution of Penninger and others, we now have a more thorough understanding of the role ACE2 plays in human physiology. ACE2 is an enzyme that is expressed on the membranes of cells, located in several places throughout the body, including the heart, lungs, arteries, kidneys and intestines. It is a critical component of a biochemical pathway known as the reninangiotensin system. In this pathway, ACE2 helps to modulate a protein called angiotensin II which increases blood pressure and inflammation, causing damage to blood vessels and other tissue injuries. ACE2 catalyzes the hydrolysis of angiotensin II into other molecules that counteract its harmful effects.3

However, in 2005, the World Health Organization (WHO) declared that SARS was contained. "Of course, now everyone was saying who cares. It's beautiful work but it has no relevance because there is no SARS," Penninger recalls. Fast-forward to 2020, the novel coronavirus SARS-CoV-2 has brought life to a screeching halt, and the irony of this research being declared "irrelevant" leaves a sour taste.

I asked Penninger what his initial thoughts were when the news broke of the novel coronavirus outbreak. He recalls: "It immediately clicked in my brain that ACE2 must be the target receptor for SARS-CoV-2 because of the similarities between the Spike protein of SARS and SARS-CoV-2." Sure enough, he was right. As the number of COVID-19 fatalities began to rapidly climb, scientists, industry leaders and global authorities assembled to search for an effective therapeutic against the virus.In April 2020, Apeiron announced it had received regulatory approvals in Austria, Germany and Denmark to initiate a Phase II clinical trial of APN01 in 200 severely infected COVID-19 patients. The announcement followed preclinical testing of APN01 in SARS-CoV-2 cell models and human-derived organoids. Often referred to as "mini-organs", organoids are three-dimensional cell cultures that can recapitulate, to a certain degree, the complexity of an organ.

How does APN01 work in the context of SARS-CoV-2?As APN01 imitates the ACE2 receptor, SARS-CoV-2 binds to it instead of the human form of the receptor. Consequently, the virus cannot enter and infect cells, so APN01 acts as a neutralizing agent and decoy. In parallel, APN01 reduces the inflammatory reactions in the lungs and protects against ARDS.

The preclinical data, published in Cell, reports that APN01 can "reduce viral growth in Vero E6 cells by a factor of 1,0005,000" and that "human blood vessel organoids and kidney organoids can be readily infected with SARS-CoV-2, which can be "significantly inhibited by human recombinant ACE2 at the early stage of infection."6Penninger believes that APN01 is probably "one of the most rational therapies you can think of" which goes beyond antibody therapies that work to neutralize the virus. In a press release, Professor Henning Bundgaard, principal investigator of the clinical trial and professor at the Faculty of Health and Medical Sciences at the University of Copenhagen said: We are eager to participate in this very promising and critical study. APN01 is an advanced drug candidate with a very strong dual rationale that may provide an important therapeutic contribution to fight the COVID-19 pandemic."

Infusion of APN01 was correlated with a gradual reduction in the levels of several diseas relevant mediators over the nine-day period, in addition to a rapid loss of viremia, and a delayed reduction in viral titers from tracheal samples and nasopharyngeal swabs.

Furthermore, infusion of APN01 did not adversely impact the patient's adaptive immune response, which was a huge factor of consideration, as Penninger told Technology Networks: "You could argue that if our molecule binds to the virus, it could divert the virus somehow so that immunity cannot kick in, making the disease even worse. Now we know the answer to this question and it looks very good."

Of course this data is obtained from just one patient, which must be considered. However, it's a positive start, and the Phase II APN01 clinical trial is still recruiting.

Peter Llewellyn-Davies, CEO of APEIRON Biologics, said in a press release: "We are delighted our drug candidate APN01 may have helped this patient to overcome the life-threatening disease and are confident to confirm these positive results in our ongoing and progressing pivotal clinical Phase II trial. The further scientific validation by this renowned journal encourages us in our efforts to providing an efficacious therapy against COVID-19 for the benefit of patients and society."

When asked whether he feels optimistic about the future of APN01, Penninger immediately responds: "Absolutely. The science here, that me and other companies are doing, points in the same direction. It will be interesting to see how this [APN01] plays out, in terms of viral load and the protecting of organs. As we know COVID-19 has other long-term effects in tissues around the body. ACE2 explains this distribution."

Penninger sounds confident, but not arrogant. It is evident that he truly believes in the science behind APN01; after all, he has committed many years of his research career to exploring it, discounting critics along the way. But in the context of the global pandemic, the clinical data is everything.

"What we do not know is: What dose should we use? Which timing for therapy is right? Should we start earlier? The clinical trial is testing the drug in severe COVID-19 patients. Would it work better when tested in patients for which the disease is not severe? These are the questions we have, and that's why we do careful clinical testing," he says. "I am totally confident about the science, but the clinical outcome let's see what the data tells us."Josef Penninger was speaking to Molly Campbell, Science Writer for Technology Networks.References:

1. Crackower MA, Sarao R, Oudit GY, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417(6891):822-828. doi:10.1038/nature00786.

2. Imai Y, Kuba K, Rao S, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436(7047):112-116. doi:10.1038/nature03712.

3. Fountain JH, Lappin SL. Physiology, Renin Angiotensin System. Treasure Island (FL): StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK470410/. Accessed September 24, 2020.

4. Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426(6965):450-454. doi:10.1038/nature02145.

5. Khan A, Benthin C, Zeno B, et al. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Critical Care. 2017;21(1):234. doi:10.1186/s13054-017-1823-x

6. Monteil V, Kwon H, Prado P, et al. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE1. Cell. 2020;181(4):905-913.e7. doi:10.1016/j.cell.2020.04.004.

7. Zoufaly A, Poglitsch M, Aberle JH, et al. Human recombinant soluble ACE2 in severe COVID-19. The Lancet Respiratory Medicine. doi:10.1016/S2213-2600(20)30418-5

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A Conversation With Professor Josef Penninger on the Journey to a COVID-19 Therapeutic - Technology Networks

New research offers guidance on how often you should feed your cat – CTV News

Those piteous, all-day, I'm-so-hungry meows from your cat may not be the best guide to keeping it healthy, new research suggests.

A paper by animal health experts at the University of Guelph says cats do just fine when fed once a day -- and may even become healthier.

"I don't know why people are so set on cats having to eat multiple small meals a day," said co-author Adronie Verbrugghe.

After all, cats in the wild -- lions for example -- eat one large meal and then nothing for days.

"They're almost like dogs."

What would happen if Fluffy got her kibble in one go instead of several? Verbrugghe asked.

"There wasn't really any (research) out there that related to physiology or biochemistry."

So she and her colleagues kept careful track of eight healthy cats' activity and internal chemistry over 21 days. Four were fed once daily; the others four times. Both groups were given equal calories.

Verbrugghe found the one-meal cats had higher levels of hormones that are released when hunger has been satisfied.

"That could show they were more sated compared to the cats that were fed multiple meals," she said.

The one-meal cats also seemed to be burning more fat and showed higher levels of amino acids -- the building blocks of muscle -- than the multiple-meal cats.

The cats fed four times a day were more active, Verbrugghe said. But that doesn't mean they were burning more calories.

"When we looked at the energy expenditure, there was no difference."

Obesity is a big problem in house cats, Verbrugghe said. One meal a day could be one way of controlling that -- although she acknowledges that food plan wouldn't be acceptable to all cats.

"This is one extra tool," Verbrugghe said. "We cannot do cookie-cutter medicine. We have to create a plan for every individual animal."

But she added that demanding multiple meals is learned behaviour in some cats. It can be a way of getting attention from their owner.

"Many people are feeding multiple small meals because they want to show that they love their animals," said Verbrugghe. "I would definitely replace a meal with interacting with the animal -- giving them some cuddles, playing with them."

Cats love routine and frequent feeding may simply be part of that.

"That's how they're used to being served food," Verbrugghe said. "Other cats may have a natural grazer habit. I don't know what the reason is for that."

Sometimes, the problem behaviour is human. With many small meals, it's easy to lose track of how much food Fluffy is actually getting -- especially when children are doing the feeding.

"That could very quickly lead to weight gain."

Despite the long mutual history between humans and cats, Verbrugghe said there's still much to learn about feline physiology. People make assumptions about what their furry friends do and how they behave that aren't necessarily backed by science.

"There's still a lot of things we don't know yet. We still extrapolate a lot from other animals or humans."

This report by The Canadian Press was first published Sept. 23, 2020

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New research offers guidance on how often you should feed your cat - CTV News