Are Organic Foods More Nutritious? – American Council on Science and Health

Plants are autotrophic, utilizing the basic elements of minerals, carbon dioxide, water, energized by sunlight through photosynthesis, to create the wide gamut of molecules they need to support their growth, including all vitamins. A crops' vitamin content is based upon the plant's genetics and the conditions it is grown in. If the growing conditions are the same, and soil composition equivalent, a tomato's nutrient content will be the same whether grown "organically" or conventionally.

Crop production specialists have several tools at their disposal to make sure that the soil is appropriately managed and the growing conditions are optimal. This management process includes soil testing and fertilization when necessary to ensure the soil has adequate minerals to grow a crop and obtain sufficient yields per acre and quality of produce. Farming operations routinely conduct a soil test to evaluate soil conditions and to amend whatever is needed. Additionally, they perform a plant tissue petiole test, which examines the plant's tissue to make sure the plant is healthy and taking up the appropriate nutrients from the soil. In the absence of adequate minerals, there would be very noticeable changes in both the plant and the produce's physical structure. As an example, below is an image of a tomato grown in calcium-deficient soil and cauliflower grown in boron deficient soil.

Appropriate mineral composition of the soil can be readily achieved; there is nothing magical about the organic methods. The tomato plant's root system will just as readily absorb and utilize synthetic minerals from fertilizers as it would minerals from manure or other forms of compost. An easily understood analogy would be an individual with iron deficiency anemia a low red blood count because of iron deficiency in their diet. Does the treating physician prescribe large amounts of red meat, an organic source of iron, or a synthetic source of iron in the form of a supplement? Our small intestines will not differentiate between the two sources of iron. The absorptive surface area of the small intestine, as the absorptive surface area of the tomato's roots, will readily absorb either source because the structure of the needed molecule, in this case, iron, is the same. The tomato root system is looking for a specified structure, not its source.

This basic plant physiology is why all well-controlled studies, utilizing identical growing conditions, will never find any significant nutrient differences that would contribute to one's health between organics and conventionally grown crops. As an example, some organics may have slightly higher levels of various antioxidant phytochemicals. This results from the organic crops' higher stress levels during growth, initiating greater antioxidant protection from oxidizing molecules due to less crop protection methods used by conventional farming. However, does this slightly higher antioxidant level equate to better health for the consumer? For a brief review of this point, see the past article on this issue.

Let's say theoretically that an organically grown orange contained 10% more vitamin C than a conventionally grown one. A large orange contains roughly 97 mg of vitamin C, more than enough to maintain the maximum storage capacity of vitamin C of 1500 mg. Our theoretical organic orange would have 10% more than this, roughly 107mg. However, as pointed out here, vitamin C intake above 100mg would result in an enhanced secretion due to the body's inability to utilize it or store it. Even if, theoretically, the organic orange contained more vitamin C than the conventionally grown one, would it make any impact on your health? The obvious answer is no. It would be analogous to having a full fuel tank and then continuing to attempt to add more. More is not better; it's just more. Just as your vehicle normally runs on a quarter tank of fuel, your physiological needs for any nutrient are met from far below maximum storage levels. Maximum storage only reflects what the body can safely store and draw upon during periods of lower intakes, prior to the nutrient being excreted or potentially toxic. Maximum storage is not equivalent to maximum health.

"From a systematic review of the currently available published literature, evidence is lacking for nutrition-related health effects that result from the consumption of organically produced foodstuffs." American Journal of Clinical Nutrition [1]

The Danish Research Centre for Organic Farming funded a study to determine the nutritional value of organics versus conventional foods by the Department of Human Nutrition at the University of Copenhagen. The study's purpose was to determine if there were any differentiation between the resulting major and trace element content of the two cultivation methods. They studied five different crops, carrots, kale, mature peas, apples, and potatoes. All were cultivated organically and conventionally under the same conditions. As the study leader, Dr. Susanne Bugel, states, they were "No systematic differences between the crops." [2] The study did not support the belief that organically grown produce is nutritionally superior.

[1] Nutrition-related health effects of organic foods: a systematic review American Journal of Clinical Nutrition DOI: 10.3945/ajcn.2010.29269

[2] S. Bugel, et al. Effect of plant cultivation methods on content of major and trace elements in foodstuffs and retention in rats. Journal of the Science of Food and Agriculture (2008), Vol. 88, pp. 2161-72. https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.3328

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Are Organic Foods More Nutritious? - American Council on Science and Health

Princess the Reindeer Gets Royal Treatment at Good Zoo – Wheeling Intelligencer

WHEELING For the fourth straight year, the public has the opportunity this holiday season to meet one of Santas reindeer and the zookeepers who train it during a unique 30-minute Reindeer Encounter at the Oglebay Good Zoo.

Good Zoo Director Joe Greathouse said while the Reindeer Encounter experience is offered year-round, it is obviously extremely popular throughout the Christmas season. He said the zoo typically averages between 125 to 150 sessions just over the holiday season.

About 50 percent of the guests are from here in the Ohio Valley region and about 50 percent come in and are staying at the resort, Greathouse explained.

Greathouse said the zoo offers the Reindeer Encounter year-round because its good for the reindeer to have that continued interaction with guests. The zoo is currently booked up with appointments through Christmas Day.

The vast majority that we book are typically at the beginning of the Festival of Lights through the end of Festival of Lights, Greathouse said.

While all patrons have the option of viewing the reindeer Princess at the outdoor exhibit, which includes a small sheltered area, signing up for the actual encounter includes a 30-minute small group session in which separate rates apply.

Those signing up for the encounter not only have the opportunity to learn about reindeer in general, they also have the opportunity to do some hands-on activities with the reindeer, such as feeding her as zoo employees offer assistance.

The zookeeper leading the experience will talk about the physical characteristics of reindeer and talk about their natural habitats.

Reindeer, also known as caribou, are a member of the deer family.

In addition to North America they are native to the arctic, tundra, evergreen forests of northern Europe and Asia. They are the only species of deer in which the male and female both possess antlers.

Good Zoo Senior Program Keeper Courtney Snyder, who leads all education programs at the zoo said the Reindeer Experience has been very popular with all ages.

Everyone loves reindeer, Snyder commented. She said while young children are most in awe of the reindeer, its surprising how adults are very interested in the physiology and stories behind the animal.

While they are booked through Christmas, encounters are offered daily throughout the Festival of Lights season at 1 p.m., 2 p.m., 3 p.m., 5 p.m., and 6 p.m.

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Using computational models for better thermoregulation in the ICU – Advanced Science News

Models that can predict and help us to understand the body's thermal state could help optimize temperature management strategies in a clinical setting.

Image credit: Markus Spiske on Unsplash

Regulation of body temperature or thermoregulation is an important function and is vital for maintaining health. In mammals, various temperature-controlling biological mechanisms are crucial for sustaining thermal equilibrium, i.e., the balance between the rate of heat production and the rate of heat loss, for which countless organisms have evolved characteristically flexible mechanisms and behavioural adaptations.

Deviations from normal core body temperatures are in general harmful, but there are also circumstances in which they can be beneficial. For instance, an elevated body temperature during fever can help fight off pathogens. In a clinical setting, the precise regulation of body temperature in the form of targeted temperature management is an instrumental part of hospital intensive care. Lowering the bodys core temperature to 32-34 C (mild hypothermia) to counteract severe hyperthermia that develops after successful resuscitation from cardiac arrest, for example, has been a part of therapeutic guidelines for almost two decades and has helped save many lives. Mortality rates improve with thermoregulation in these patients. The therapies also provide better neurological outcomes by protecting the brain against lack of oxygen and reduced perfusion.

While potentially lifesaving, inducing changes in body temperature in a clinical environment is difficult and associated with many secondary changes in physiology that can be detrimental, such as a profound lowering of the heart rate, increased urine output, and changes in electrolyte concentrations. With temperature management also come numerous additional therapeutic and diagnostic procedures (e.g., emergency coronary catheterization, CT scans, insertion of vascular catheters), all of which are time sensitive.

Additional challenges arise from variability in patient response as well as the fact that a variety of different methods to achieve temperature reduction exist, such as intravenous infusion of cold fluids, cooling blankets, endovascular cooling catheters, among others. Each of these has its benefits as well as drawbacks but predicting how a patient will respond and what the best course of action is can be difficult to predict. Therefore, it is of utmost importance to find new and even better temperature management techniques.

In recent years, computational bioheat models have been proposed to better understand the underlying bio-thermal processes and to predict changes in a patients thermal state. In these models, the human body is typically represented by two interacting systems of thermoregulation: the controlling active system, which represents the human bodys regulatory responses (e.g., vasoconstriction, vasodilation, shivering, sweating, and metabolic heat production) and the controlled passive system (e.g., thermal interactions between the body and the environment).

Many models available today are based on a composite model of the human body that consists of several cylinders representing the head, the corpus, and the upper and lower extremities. Heat exchange occurs between different body segments via blood flow and also within the segments by means of different heat transfer processes between the core, skin and blood.

Biothermal models of the human body are becoming increasingly comprehensive and an ambitious goal would be to combine a real-time and easy-to-use measuring device with a computational thermal model that is tailored to individual patients and can be used to predict and precisely regulate patients temperature changes during a hospital stay. The hope is that they will also aid in the design of special-purpose devices to control the delivery of thermal energy to targeted regions and to improve the treatment of diseases such as the delivery of therapeutics in cancer patients. This method is also known under the name temperature-controlled drug release.

One potential and promising example is the release of molecules from mesoporous silica nanoparticles that can be intravenously administered and react to an external heat stimulus (e.g., magnetic field). Especially in combination with advances in smart bio-measurement technologies, such interdisciplinary approaches have great potential for optimizing temperature management strategies in a variety of clinical settings. This is another example of how interdisciplinary endeavors at the interface of physiology, clinical research, biometrics, and biophysical modelling can lead to novel and innovative solutions.

Written by:

Kristijan Skok, General Hospital Graz II, Location West, Institute of Pathology, Gstinger Strae 22, 8020 Graz, Austria and University of Maribor, Faculty of Medicine, Taborska ulica 8, 2000 Maribor, Slovenia

Maja Duh, University of Maribor, Faculty of Natural Sciences and Mathematics, Koroka cesta 160, 2000 Maribor, Slovenia

Andra Stoer, University of Maribor, Faculty of Medicine, Taborska ulica 8, 2000 Maribor, Slovenia

Andrej Markota, University of Maribor, Faculty of Medicine, Taborska ulica 8, 2000 Maribor, Slovenia and University Medical Centre Maribor, Medical Intensive Care Unit, Ljubljanska 5, 2000 Maribor, Slovenia

Marko Gosak, University of Maribor, Faculty of Natural Sciences and Mathematics, Koroka cesta 160, 2000, Maribor, Slovenia and University of Maribor, Faculty of Medicine, Taborska ulica 8, 2000 Maribor, Slovenia

Reference: Kristijan Skok et al., A Journey from Physiology to Computational Models and the Intensive Care Unit, WIREs Systems Biology and Medicine (2020). DOI: 10.1002/wsbm.1513

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Using computational models for better thermoregulation in the ICU - Advanced Science News

Are sports hurting the climate? (And other awkward questions) – Stuff.co.nz

Professor Jim Cotter stops to think carefully about what hes going to say.

He wants it to come across the right way. Plus, its tricky asking tough questions about sport, the sacred cow of New Zealand society.

But its time: I don't really don't want to put blame anywhere because in many ways they're trying to do the right thing, says the Otago University environmental exercise physiologist.

Yet when Cotter was asked to deliver a keynote address at the Sports and Exercise Science Conference last month, he found there was only one thing he wanted to talk about: climate change.

Specifically, are high performance sports hurting the very conditions we rely on for a healthy life? And for those sitting on the couch watching from home, are our sedentary lifestyles leaving us more vulnerable as the planet warms up?

READ MORE:* New Transport Minister promises to 'get moving quickly' to cut emissions* Round the Bays: How not to go backwards in your training this festive period* New Zealanders are fat and in denial about it, says survey

It seems counterintuitive to have a dig at sports. After all, when people think of sports, they often think of being outside in the fresh air, wild and free, running around at a park: what could be better for the environment?

But Cotter says, whoa, hold on a second theres a lot more to it than that.

In elite sport, there are things which have become accepted norms that he thinks need seriously reconsidering: altitude training and overseas competitions, for instance.

Even in kids sports: do parents really need to be dropping their kids off for lengthy warm-ups?

And, as a society, he says, its time to think about how the way we live is diminishing our ability to cope with climate change.

In the process of us making a built, protected environment were making the real environment more extreme, and we're also making ourselves less resilient, says Cotter.

We're going towards a train wreck, and we know it's happening.

Supplied

A Cotter family adventure at Mt Titiroa, with Professor Jim Cotter's children Lucy, Hamish, and Grace. Cotter grew up on the West Coast, where he developed a love for the outdoors.

You could say that Cotter's connection to the environment is coursing in his veins. He grew up in Rotomanu, in the wilds of the West Coast; a childhood filled with grazed knees from scrambling through the bush and wet hair from floating down the river on tractor tyre inner tubes.

We were free to explore, which was acutely dangerous, probably, but it gives you a capability, mentally as much as anything. You just relish in that freedom, and your parents literally didnt know where you were as long as you were home for dinner.

Cotter studied for a science degree at Otago, majoring in physiology and physical education, before completing a doctorate in environmental physiology at the University of Wollongong. He landed a job at the Australian Defence Science and Technology Organisation where he investigated how people cope with adverse environmental conditions, a field of research he has kept up for the past two decades.

Cotter has been back at Otago University for almost 20 years, during which time hes also sustained his love of the outdoors and competing himself. He was an original at the first Kepler Challenge, a 60 km mountain race over the Great Walk in Fiordland, and fondly remembers early Coast to Coast races, just for the adventure of it.

Other favourite outdoor memories include taking on traverses of the Southern Alps, especially being a useful part of a small, well-functioning group negotiating through some pretty amazing places.

Supplied

Cotter's daughter, Grace, on a family adventure at Ball Pass, Aoraki. For the past few decades he has studied how humans cope in extreme environments.

For someone who has enjoyed a life of fitness, then, you can sense a tinge of sadness from Cotter about the decline in the countrys fitness levels. He cites figures from the Dunedin longitudinal multidisciplinary study that show how much fitness has slipped. Fathers are about 20 per cent fitter than their sons, and mothers are about 35 per cent fitter than their daughters that's one generation.

As well as the health impacts of declining fitness and increasing weight (at the moment, theres one person in the world dying every eight seconds from Covid-19 theres one person every six seconds dying from Type Two diabetes alone), he worries about how we are becoming less conditioned to cope with climate change.

There are physical benefits of fitness your body is more efficient at coping with heat, for instance but theres a mental benefit too.

Fitter people have more mental resilience, he says. In one study of this, endurance athletes, team sport players and sedentary people held their arms in ice-cold water to see how long they could last.

After two minutes, 90 per cent of the endurance athletes still had their arms in the water, whereas only half of the other two groups did. That either tells you endurance athletes are stupid or theyre stubborn, he laughs, or theyre mentally resilient. Cotter believes its the third option.

James Allan/Getty Images

Jim Cotter says fitness helps build mental resilience.

And resilience is going to come in handy as climate change unfolds with fitness, youve got the capacity to tolerate more.

How do we build resilience? Choosing to bike to work or not turning the air conditioner on. Its not only our physical capabilities its what were prepared to put up with.

Meanwhile, the environment weve built for ourselves is not helping us in our ability to react and adapt.

Our constructed environment insidiously removes transiently useful stresses. What does he mean by this? By making things too easy for our bodies, they dont learn how to deal with the stresses of heat, for instance.

We don't have thermal stress because if it gets hot, we turn the air conditioner on, if it gets cold, we put a heater on. We don't expend physiological costs to move against gravity because we make the remote controls open our doors.

We make it easy for us and in the process, it decays what we are.

Scott Heavey/Getty Images

Sports teams travel the world for competitions but is all that flying the right thing to do?

In his speech to the conference, his early slides made their way through those impacts of fitness and mental resilience topics where, in the most part, there are choices to be made for individuals.

Then it came to the touchier topic: how high performance sport is coping with, and impacting, climate change.

Again, as he speaks, he emphasises he doesnt want to put the boot in, like some thuggish oaf on the rugby field. His preference is to start a conversation, not blow the whistle.

After all, there is plenty at stake for sports themselves. Already, scientists are warning about the impact of climate change on cricket, for instance not just because of increasing temperatures, or loss of topsoil, but raising the question whether increased pressure on resources will lead to conflict in some regions. You cant play a test match in a warzone.

Ryan Pierse/Getty Images

Scientists are already warning about the impact of climate change on the future of sports, including cricket.

Sports organisations, Cotter says, talk about sustainability, but Im asking them to think about whether theyre prioritising this stuff enough.

Were living in the age of decadence. And sport, I think, is part of that decadence.

International competition, for instance, has teams flying around the world, stomping large carbon bootprints around the planet. Again, its not about blame academics are just as bad. We travel the world, and we dont necessarily need to.

But hes calling on sports to reconsider their priorities. Covid taught sports that it was possible to have virtual races, for instance, athletes competing in their home countries and comparing results. Its not the same as racing side-by-side, no, but maybe every second championship could be virtual and then youve immediately halved your footprint.

And when it comes to flying teams around the world, maybe they need to reconsider how big a squad they take, including support staff. Saving just one flight would make a significant reduction in the cost to the environment.

But Cotter is not interested in lecturing sports and their administrators. As a member of the sports science community, he says, he and his colleagues are here to help.

If he has a plea, its that sports listen to the science.

Doug Pensinger/Getty Images

Many endurance athletes head to high altitude areas to try to help their bodies boost their oxygen-carrying capacity but is that a good idea?

Take altitude training, for instance. For decades, athletes in endurance sports have put great stock on going to high altitudes for training camps to gain the benefits of boosting the oxygen-carrying capacity of their blood.

And yet, says Cotter, studies have established that many athletes dont get any benefit from being at altitude its a gene response issue and there are tests that can be done at sea level to see who will or wont gain from being in the mountains.

Weve known this for 20 years, and we still dont even do the basic testing before we send a whole team off to the other side of the world. Its destructive in two respects: ones on the planet, and ones on the individuals adaptability.

If teams want the benefit of being in camp, why not send them to Whngarei instead of Europe or Colorado?

Besides, he says, in a paper published this year scientists showed it was possible to get the same blood-boosting effect without having to go to altitude: by micro-dosing with carbon monoxide.

Before people react to carbon monoxide, Cotter points out, if we live in a city, we have carbon monoxide in our blood.

So, whats he saying, instead of heading for the hills, go sit in traffic?

Cotter laughs. You might say, micro-dosing with carbon monoxide is not ethical. But is this ethical, flying to the other side of the world? Especially when many athletes will get no physiological benefit.

Look, I dont know the answers to these things. But he thinks its important to ask the questions, and think about them.

Otherwise, we just go along with the accepted norms, even when theyre unproven.

This sets Cotter off on another example: warm-ups. Teams and individual athletes build up their warm-up routines which can often take an hour or more.

Supplied

Professor Jim Cotter encourages New Zealanders to get out in the wild outdoors to not only build fitness but to build empathy for the natural environment.

But Cotter says, as far as the body is concerned, this is unnecessary. We've been doing studies on muscle temperature response to exercise and it takes about two minutes to warm a muscle up. We think even for very high intensity using all energy systems at maximum you probably need about six minutes.

Six minutes. Think about that next time you have to be at a ground an hour-and-a-half before kick-off to drop someone off.

Cotter points out this causes fuel pollution and road congestion. As the driver, you dont want to sit there and wait for an hour-and-a-half, so you go away and come back.

Coaches will say, but hang on, players need to get their heads in the game, too thats a part of warm-up. But is that because youve created the expectation that you need to spend an hour warming up? says Cotter.

In the meantime, he says, players unnecessarily burn fuel their muscles will need during the match or race, and kill their enthusiasm.

Joseph Johnson/Stuff

Town planners can create environments that make it easier for people to choose to exercise.

Cotter is conscious of killing peoples enthusiasm. Its why he doesnt want to turn people away from the problems of climate change by bashing their heads over it.

And why he thinks that, as a country, we need to find ways for people to become fitter, and to exercise and compete in a way that has a lower environmental impact.

We have to do something that works with the environment and utilises it, doesnt damage it, and develops empathy for it.

To that end, he says, its not coaches, athletes or scientists who will have the biggest impact.

The most important people are the people who create an environment where people will exercise: so that's city planners.

We can't afford not to prioritise active lifestyles because we simply won't have the health budget to deal with what's coming, and we have climate change we have to engage.

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Are sports hurting the climate? (And other awkward questions) - Stuff.co.nz

Tips for staying healthy and managing stress over the holidays – William & Mary News

by Adrienne Berard | December 18, 2020

As we head into the holidays, W&M News spoke with Dr. Elizabeth De Falcon to learn about ways relieve stress and practice self-care over winter break, to strengthen our collective immune systems. Dr. De Falcon is a practicing physician with William & Marys Health Services. She is a licensed pediatrician and Fellow of the American Academy of Pediatrics.

In the simplest terms, stress is just your body's reaction to any change that requires response. So, it could be anything: a mental strain, a physical strain or even an emotional strain. Honestly, it's different for every person. What stresses me out may not stress you out, but if were talking about physiology, then our stress response would be mostly the same.

Without going into the specific names of all the different parts of your brain, it's just that your brain perceives stress or danger or threat. Then it sends out a signal from what is essentially the command center of your brain to the rest of your body, through the nervous system. Then the nervous system starts acting on a fight or flight response and all these different neurotransmitters and hormones get released. All these different substances start flowing through your body just to get you prepared to respond to that stressor.

A lot of times, you're not even aware of it. Most of the time the threat comes and goes, and as the threat goes away, the stress response decreases. Think of a car whizzing past you on the street. Its stressful for a second, but the feeling is very short-lived. Its important to understand that not all stress is bad. It serves an important biological purpose. The stress response has been vital to our survival and evolution. When the saber-toothed tigers were hunting us down, our bodies learned how to respond to that.

If you translate that to now, lets say you're taking a test and you feel a little bit stressed. You're supposed to have a certain level of stress, because its your bodys way of motivating you to focus on something important. After the test is done, theres this sigh of relief because that stress is gone and your body just goes back to a kind of homeostasis where it's feeling ok.

But sometimes that stress hangs around for a little while. Thats when you start running into problems. You may find that even though the threat is gone, youre not feeling better. You may be experiencing increased heart rate and breathing or generally feeling edgy all the time. Thats a sign that you're bumping over into a low-level, acute stress or chronic stress state.

Thats when we start to think about cortisol. Youve probably heard about cortisol as a stress hormone. In the moment, it actually helps your body boost its immune system and decrease inflammation, but if it's there for a long time, then you start to get into different problems.

I always tell people to seek medical help if they start seeing signs of chronic stress. Some of the red flags would be that you feel in a low mood all the time. You may stop hanging out with your friends or your family. You're just kind of retreating and not interested in the things you used to be interested in. You may be sleeping too much or too little. Some people experience physical symptoms. They have an upset stomach or heartburn or headaches, because their blood pressure is up. They might feel a knot in their chest. All of those things could be signs that you're experiencing anxiety, so you would definitely want to see your doctor at that point.

It comes down to the basics of general healthy living. For example, if youve not been on a good sleep schedule over the semester, you really need to prioritize getting on a healthy sleep scheduleand make it a realistic schedule that you can keep doing once we get back on campus. If you were not addressing your dietary needs during the semester, start to incorporate healthy, nutrient-dense types of foods into your diet.

Also, exercise is super important. Just from a perspective of improving your cardiovascular health and improving your circulation, regular exercise will help get all those immune cells pumped around your body. You don't want to smoke and try to minimize your alcohol intake.

Then, of course, what weve all been focused on over these last nine month is taking steps to minimize infections. So, being very diligent about washing your hands, keeping your distance from pretty much anyone who doesn't live in your house, and wearing a mask if you have to go out and about.

When you have a healthy immune system, when it's functional, you don't even know it's there. It's protecting you from things that are trying to kill you, viruses and bacterial infections, but you arent even aware of it.

But just like a car runs out of gas when left idling, if you are not fully addressing the things that boost your immune system, eventually that car will run out of gas and then that leads to a whole host of problems. You might start noticing that you're getting more colds or struggling to get over minor illnesses. Thats really just because when your stress response is revved up all the time, it has the opposite effect on your health and it starts down-regulating your immune system.

This is something I always recommend to my patients: practice gratitude. Its such a simple, easy thing that anyone can do. It doesn't have to be complicated. Just get a little notebook, or even make mental notes, and focus on three things that you're grateful for in a day. No matter how crummy the day is, there's always something that we can find that we can be grateful for.

Studies show that if you practice gratitude, there are positive changes in your brain that actually change your outlook on things. Along those lines, the Wellness Center has all kinds of wonderful mindfulness, meditation and exercise resources available online. They make it really easy to access, so Id also recommend trying out some of those offerings.

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Tips for staying healthy and managing stress over the holidays - William & Mary News

Surrogacy and HFEA Update: December 2020 (Part 2) – Family Law Week

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In the second part of his surrogacy and HFEA update, Andrew Powell of 4PB analyses recent important judgments from Scotland and Northern Ireland.

Andrew Powell barrister, 4PB

For Part 1 of this article, covering judgments in the jurisdiction of England and Wales, please click here.

SB v University of Aberdeen [2020] CSIH 62

A Scottish decision in which the Inner House of the Court of Session granted a widow's petition to allow her to use her late husband's sperm for IVF treatment. The primary question was whether or not his will, together with forms signed consenting to the use of his sperm in inter alia intra uterine insemination (IUI), constituted the requisite consent for use in IVF under HFEA 1990, Sch. 3.

The parties (JB and SB) met and married. When JB's serious illness recurred, they agreed to commence fertility treatment, and were referred to a consultant by their GP. On medical advice JB had stored his sperm at the onset of his disease ten years previously and prior to meeting SB. Unfortunately however, JB's health deteriorated before treatment could begin.

It was discovered the day before he died, by which time he was unconscious, that the forms he had previously completed provided his consent only to the use of his sperm in inter alia IUI, and not IVF (which involves creation and storage of embryos).

Nonetheless, JB had discussed his wishes with his father, and a clause had been inserted into his will headed "Human Fertilisation and Embryology" and which directed his executors to ensure that "my donation of sperm will be for as long as possible and for as long as she may wish, available to [SB]."

SB petitioned the court asking it to exercise its powers under the nobile officium, and grant certain orders to allow her to use her late husband's stored sperm in IVF treatment. The issue before the court therefore was whether or not the will, either alone or in combination with the forms JB had signed giving consent to IUI, constituted consent by JB for the use of his sperm in IVF, as required in HFEA 1990, Sch. 3. Further, SB sought the storage of JB's gametes to be extended beyond the normal statutory period of ten years. The court concluded as follows (20-23):

"20. We proceed on the basis that the requirements of an effective consent to use of the deceased's gametes for IVF treatment are that:

(a) It must be in writing;

(b) It must be signed by the deceased;

(c) It must specify the purpose of use, and be clear that it encompasses consent to the creation of any embryo in vitro ;

(d) The individual must have been given a suitable opportunity to receive proper counselling about the implications of taking the proposed steps, and have been provided with such relevant information as is proper; and of the consequences in respect of the possibility of variation or withdrawal of consent as specified in schedule 4, paragraph 4 ; and

(e) It must not have been withdrawn.

In our view, the terms of the deceased's will constitute sufficient consent to meet these requirements. It is in writing, it is signed and it has not been withdrawn. The remaining two conditions for effective consent relate to the opportunity for counselling and whether the terms of the clause are sufficiently clear to provide consent for the specific form of treatment that is involved in IVF.

21. As to the first of these, it is clear that the deceased was, at the time of his first visit to the clinic at the start of his illness, provided with suitable and appropriate opportunities for counselling in respect of the steps which he was then undertaking. What is "a suitable opportunity to receive proper counselling", or provision of "such relevant information as is proper" is, as is accepted by the HFEA, situation specific. The context in which the deceased and the petitioner consulted their GP and were referred to the consultant and thus to the fertility clinic, was one in which they were investigating the possibility of having a child in the face of JB's impending death. It seems clear to us, taking together the affidavits of the consultant and the petitioner, that the terms of paragraph 3 of schedule 6 were adequately met before the deceased signed his will about two months after being seen by the GP and consultant. In addition, during their consultation with the consultant, the couple completed and signed a fertility clinic "Welfare of the Child" consent form. Under the heading "we have considered the following issues", they ticked a box stating "Our possible need for and the availability of independent counselling". The form was signed by both of them. The referral letter from the consultant to the clinic stated "The couple seem to have considered the difficult road ahead". The Authority accepts that treatment by IVF appears to have been in the contemplation of JB, and the affidavit of SB makes this clear. We consider therefore that there was a discussion, albeit limited, about IVF which was in the circumstances sufficient to meet the statutory requirements.

22. The remaining issue relates to the construction of the clause in the will. It is axiomatic that we should start by examining the plain meaning of the words in the context in which they occur. We regard the following features as important. First, it is a testamentary document in which JB was not only making disposition of his estate but, by this clause, expressing his wish for the future use of his stored gametes. Second, he and his wife had sought and been referred for treatment to en able them to have a child. Third, although it is expressed as a direction to his executors, in reality it is an expression of his wishes. For present purposes, we are not concerned with whether the clause could be given testamentary effect. The only question is whether it can be construed as granting the necessary consent. In our view there is no doubt that it can. It is the sort of provision that would only sensibly be made by a man contemplating his death in the near future, and seeking to make his wishes clear. The heading refers not merely to fertility but to "embryology". The clause itself is expressed unconditionally and in the widest terms. It specifies that the material be "available" to SB, in other words available for her unqualified use, thus covering the prospect of her treatment, given the known context, and meeting the terms of paragraphs 6(2) and 2(1)(b) of the schedule. All these factors point unerringly toward JB having given consent to IVF treatment. Consent to use of the gametes for the purpose of IVF must impliedly include consent for the storage of any embryos thereby created, thus meeting also the terms of paragraph 8 of the schedule .

23. Where it is desired to store gametes for a period in excess of ten years for the provision of treatment services there must be written consent of the donor and a medical opinion to the effect that that person was, or may have been likely to become, prematurely infertile ( Human Fertilisation and Embryology (Statutory Storage Period for Embryos and Gametes) Regulations 2009, regulation 4(3)(a) and 4(3)(b) ; and In re Warren [2015] Fam. 1). The clause in the deceased's will, specifying that the material be available to the petitioner for "as long as possible", together with the opinion of the treating oncologist as to the deceased's state of fertility, clearly meet these requirements."

The orders sought by SB were granted therefore, with the precise wording by consent and agreement of the parties (see 24).

Ms A and Ms R & Ors [2020] NIFam 6 A same-sex couple applied for a declaration of parentage in order to ensure that both of their names appear on the child's birth certificate. The court found itself unable to make a declaration of parentage, concluding that both s.42 and s.43 HFEA 2008 did not apply in the instant case. The court held it was also unable to make a declaration of parentage on the basis of social and psychological parentage; could not read s.42 to include couples in an "enduring relationship"; and refused to make a declaration of incompatibility with the ECHR Articles 8 and 14.

The decision involved a lesbian couple, R and A. They wished to co-parent a child, and sought a donor, P, who provided sperm with which in 2014 R conceived the child in question (C), who was born in the same year. A and R were not married or in a civil partnership at the time. R was listed on C's birth certificate as C's mother and only parent. P's name was not on the birth certificate, and crucially nor was A's.

The court had two key applications before it:

1.P's application for contact with C. The court noted that the role P was to play in C's life had not been definitively agreed between the parties. P contended he was to play some sort of part in C's life, including having at least one visit soon after C was born. R and A objected to this which in turn led to P making an application for contact. The court noted that:

"3. Regrettably there was never a written or agreed formulation of what role Mr P would play in C's life e.g. when he would see C, how often he would see C, how he would be introduced to him, how his children would be introduced to him or how he would be known to him. It is appalling that the planning between the adults for something so important and long lasting was so inadequate. People put more care into arranging a holiday than these three adults did for C. To the extent that there were discussions the outcome was incomplete and incoherent."

R and A challenged P's right to seek contact on the basis that he is not C's father in any way which should be recognised by the court. (Note that despite seeking contact, P did not seek to have his name added to C's birth certificate.)

2.A's application for a declaration of parentage under Article 31B of the Matrimonial and Family Proceedings (NI) Order 1989 ("the 1989 Order") naming her as C's second parent, and enabling her to be added to C's birth certificate. R and A subsequently entered a civil partnership, and wished for A to be added to C's birth certificate as a second mother. They argued P was not the natural father of C, and they were C's only natural parents. A sought to argue that a refusal to add A's name to C's birth certificate would be incompatible with her rights, and those of C and R, to family life pursuant to Article 8, and Article 14 insofar as she would be a victim of discrimination based on her status of being other than married or civil partnered. A, supported by R, argued that C was born when they were in an "enduring relationship" which should be officially recognised and respected as being equivalent to a civil partnership or marriage.

Further, A argued that she was a parent to C in the social and psychological sense recognised by Lady Hale in Re G [2006] UKHL 43, and the court should in the alternative make a finding of its own accord that a declaration of parentage is appropriate.

A sought that s.42 of the HFEA 2008 was to be read so as to apply to A even if she was not married to R or in a civil partnership because she was in an "enduring relationship". Alternatively, A sought a finding that s.42 was incompatible with the ECHR Articles 8 and 14, and also a finding that s.43 was incompatible because it required A to have received treatment services through a licensed clinic.

A argued it was not sufficient for her to benefit from any of the orders which might be made under the Children (NI) Order 1995 ("the 1995 Order), such as an order for parental responsibility or a joint residence order with R. Whilst these orders are of some value, A argued that they do not carry the permanence of registration as a legal parent on the birth certificate and are vulnerable to challenge as circumstances change. Nor would it be sufficient for her to become an adoptive parent. A argued she could only have her position recognised adequately if she was declared to be a parent.

The Department of Finance, the UK Secretary of State for Health and the Attorney General resisted these submissions, as did P.

The Law The court considered the HFEA 2008 in detail, including the provisions in ss.42 and 43 (10-22), and the provisions of the 1989 Order (4-5).

It concluded that if A fell within either s.42 or s.43 of the HFEA 2008 and was therefore "treated as a parent of the child" she would be entitled to a declaration of parentage under Article 31B of the Matrimonial and Family Proceedings (NI) Order 1989 ("the 1989 Order"), and in turn able to be registered on C's birth certificate as his second parent.

Sections 42 and 43 of HFEA 2008As A was not R's civil partner until C was born, s.42 did not apply (24).

Further, s. 43 did not apply either because R did not receive treatment from a licenced services provider, and the specified female parenthood conditions in s.43 had not been complied with in any way. This included the fact that A and R had not signed consent forms with a declaration acknowledging that they had received information about different options available, had been offered counselling, understood the implications of their consent, and was aware that the consent could be changed or withdrawn up to a certain point. The court noted that all of this was absent in this case and that "[t]hese consents are not incidental matters, they are fundamental to the process" (24).

ConclusionsThe court noted that:

"29. The 2008 legislation recognises married couples, couples in civil partnerships and unmarried couples in Sections 42 and 43 subject to certain conditions. None of those conditions is one which Ms A could not have complied with. Had she and Ms R entered a civil partnership earlier they would have come within Section 42. Alternatively they could have gone through a licensed clinic and met the demands of section 43. They chose not to do so and now seek to avoid the consequences of their deliberate decisions."

The court declined to read s.42 to include people in an "enduring relationship" as to do so would "open the door wider [] only ends the certainty which the legislation has sought to achieve in this complex and difficult area." (31)

In respect of A's submission that the court should make a declaration of legal parentage for the purpose of Article 31B of the 1989 Order on the basis of social and psychological parentage, the court followed Jackson J in Re G (Unregulated Artificial Conception) [2014] EWFC 1, where the court had concluded the existence or non-existence of psychological parenthood was not an apt subject for a declaration parenthood. In short, the court considered A was "asking much too much":

"32. Providing social or psychological parenting for a child is of enormous importance and value to a child as Lady Hale recognised. However, in my judgment, it is really quite different from what Article 31B contemplates and requires. At different times in a child's life one adult may leave the scene and another one arrive on it. That new adult might become central to the child's well-being and positive development on a long term basis. Wonderful as that is for the child it is not a basis for adding his or her name to the birth certificate."

The court ultimately concluded very strongly that:

"33. Ms A is not and cannot be the natural parent of C. Had she and Ms R taken one of the routes open to them they could have become the recognised legal parents. By failing to do so they have lost that opportunity, at least so far as Ms A is concerned."

In respect of the arguments raised by A regarding compatibility with the ECHR, the court held that whilst Article 8 is engaged and to an extent has been interfered with, the interference is "extremely limited" and justified because:i.As noted above, A had the opportunity to become a legal parent through the routes provided for by s.42 and 43 of the HFEA 2008: "It is not the law which denies second parentage to Ms A. On the contrary it is her failure to take any of the steps open to her by law." (34)

ii.While the interference is necessary to introduce certainty into the complex area of parental relationships, it is limited by the variety and combination of alternative orders which would be able to cement A's place in C's life (i.e. orders for parental responsibility and shared residence which, in the circumstances of this case, are likely to be long lasting in their effect as P was not seeking anything more than some form of contact) (34).

Further, in respect to the submissions that she had been discriminated against contrary to Article 14, the court found against A as the provisions in ss.42 and 43 allowed for recognition of a second parent of a woman who is in a marriage or civil partnership (s.42), or outside of a marriage or civil partnership (s.43). No comparator was found.

A declaration of parentage pursuant to Article 31B of the 1989 Order was declined. No declaration of incompatibility with Articles 8 and 14 of the ECHR were made either.

16/12/20

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Surrogacy and HFEA Update: December 2020 (Part 2) - Family Law Week

Novartis buys neuroscience company Cadent for up to $770 million – CNBC

Signage is displayed on the exterior of the Novartis AG Institutes for BioMedical Research building in Cambridge, Massachusetts, U.S., on Friday, Aug. 5, 2016.

Scott Eisen | Bloomberg | Getty Images

Novartis said on Thursday it would acquire U.S.-based neuroscience company Cadent for up to $770 million, gaining full rights to Cadent's portfolio.

"Cadent will receive a $210 million upfront payment and will be eligible for up to $560 million in milestone payments, for a total potential consideration of $770 million," Cadent said in a statement.

Novartis said the acquisition added two new clinical stage programs to its neuroscience portfolio, one for schizophrenia and the other for movement disorders.

It also includes a buyout of milestones and royalties for MIJ821, a clinical stage molecule that Novartis licensed exclusively from Cadent in 2015 and that it is actively developing for treatment resistant depression, Novartis said.

Cadent and Novartis said they expected the transaction to close in the first quarter of 2021. Closing of the transaction is subject to customary closing conditions.

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Novartis buys neuroscience company Cadent for up to $770 million - CNBC

Theranexus : THERANEXUS, LYON NEUROSCIENCE RESEARCH CENTER AND CERMEP ANNOUNCE THE CREATION AND FUNDING OF NEW JOINT PUBLIC/PRIVATE LABORATORY…

The laboratory obtained funding of350,000 from the French National Research Agency (ANR).

Lyon, 18 December 2020 Theranexus, a biopharmaceutical company innovating in the treatment of neurological diseases has announced the creation and funding of a new joint public/private laboratory in partnership with the BIORAN team from the Lyon Neuroscience Research Center (CRNL) and CERMEP (Hospices Civils de Lyon, Claude Bernard Lyon 1 University, INSERM, CNRS), the regional biomedical imaging core dedicated to clinical and basic research.

This laboratory, NeuroImaging for Drug Discovery(NI2D), aims to improve understanding of the cellular and molecular mechanisms of drug candidates developed by Theranexus in particular at the neuronal and astrocyte level using novel preclinical neuroimaging tools.

The approach taken by Theranexus calls for the development of novel neuroimaging tools and we are delighted to continue our successful collaboration with this company in connection with our joint NI2D laboratory explains Prof. Luc Zimmer, Director of CERMEP and the BIORAN team at the Lyon Neuroscience Research Center.

We are very happy to be given the opportunity to create this joint laboratory with the research teams at the cutting edge of innovation in neuroimaging from BIORAN and CERMEP and we would like to thank ANR for its funding. This laboratory will be dedicated to improving understanding of the neuronal and glial cell mechanisms of Theranexus drug candidates concludes Franck Mouthon, Chairman, CEO and co-founder of Theranexus.

This project is supported by funding of350,000 from the French National Research Agency, which comes in addition to the200,000 already obtained from the Auvergne-Rhne-Alpes Region1. The two partners are actively contributing through the provision of staff and equipment.

About Lyon Neuroscience Research Center (CRNL; supervisory authorities: Claude Bernard Lyon 1 University, INSERM, CNRS)

CRNL combines the expertise of 18 teams whose common aim is to develop multidisciplinary research in a bid to understand the complexity of brain function as well as certain dysfunctions in relation to neurologic or psychiatric conditions.

Within CRNL, the BIORAN team (Radiopharmaceutical and neurochemical biomarkers) brings together expertise in neurochemistry, neuropharmacology and neuroimaging with the aim of inventing novel probes and imaging protocols for investigating the biochemistry of the brain in diagnostic and therapeutic settings.

1https://www.theranexus.com/images/pdf/Theranexus_CP_Point_Actualite_Scientifique_VDEF.pdf

2020 ActusNews

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Theranexus : THERANEXUS, LYON NEUROSCIENCE RESEARCH CENTER AND CERMEP ANNOUNCE THE CREATION AND FUNDING OF NEW JOINT PUBLIC/PRIVATE LABORATORY...

Whether it’s 2020 or Baby Shark: Study offers clues on how to stop thinking about it – CU Boulder Today

Let it go. Think about something else. Clear your head.

In our attempts to de-clutter our busy minds and make room for new, often more productive thoughts, people tap an array of different approaches. Which works best, and how does each strategy distinctly impact the brain?

Researchers at the University of Colorado Boulder and the University of Texas at Austin have taken a first stab at answering this question, combining novel brain imaging with machine learning techniques to offer an unprecedented window into what happens in the brain when we try to stop thinking about something.

The findings, published this month in the journal Nature Communicationslend new insight into the basic building blocks of cognition and could inform new therapies for issues like post-traumatic stress disorder and obsessive compulsive disorder. They also provide clues on how to form better study habits or innovate at work.

We found that if you really want a new idea to come into your mind, you need to deliberately force yourself to stop thinking about the old one, said co-author Marie Banich, a professor of psychology and neuroscience at CU Boulder.

For the study, Banich teamed up with Jarrod Lewis-Peacock, a cognitive neuroscience at UT Austin, to examine brain activity in 60 volunteers as they tried to flush a thought from their working memory.

As Lewis-Peacock describes it, working memory is the scratch pad of the mind where we store thoughts temporarily to help us carry out tasks. But we can only keep three or four thoughts in working memory at a time. Like a sink full of dirty dishes, it must be cleaned out to make new ideas possible.

Once were done using that information to answer an email or address some problem, we need to let it go so it doesnt clog up our mental resources to do the next thing, he said.

When we ruminate over something perhaps the fight we had with a friend or an offending text that can color new thoughts in a negative light. Such rumination is at the root of many mental health disorders, said Banich.

In obsessive compulsive disorder it could be the thought of as, If I dont wash my hands again I will get sick. In anxiety, it might be, This plane is going to crash.

A study subject has her brain scanned in an fMRI machine at CU Boulder.

To determine if people can truly purge a thought, and how, the team asked each volunteer to lay down inside a functional magnetic resonance imaging machine (fMRI) at the Intermountain Neuroimaging Center on the Boulder campus.

They were shown pictures of faces, fruits and scenes and asked to maintain the thought of them for 4 seconds. Meanwhile, researchers created individualized brain signatures showing precisely what each persons brain looked like when they thought of each picture.

Afterward, participants were told to: replace the thought (replace apple with mountain); clear all thoughts (akin to mindfulness meditation); or suppress the thought (focus on it and then deliberately try to stop thinking about it). In each case, the brain signature associated with the image visibly faded.

We were thrilled, said Banich. This is the first study to move beyond just asking someone, Did you stop thinking about that? Rather, you can actually look at a persons brain activity, see the pattern of the thought and then watch it fade as they remove it.

The researchers also found that replace, clear and suppress had very different impacts.

While replace and clear prompted the brain signature of the image to fade faster, it didnt fade completely, leaving a shadow in the background as new thoughts were introduced.

Suppress, on the other hand, took longer to prompt forgetting but was more complete in making room for a new thought.

Behavioral studies outside the scanner yielded similar results.

The bottom line is: If you want to get something out of your mind quickly use clear or replace, said Banich. But if you want to get something out of your mind so you can put in new information, suppress works best.

More research is necessary, but the findings suggest that students may want to pack up their algebra notes, take a break and deliberately try not to think about quadratic equations before moving on to study for physics.

Hit a wall on that report at work? Let it go for a while.

People often think, If I think about this harder I am going to solve this problem. But work by clinicians suggests it can actually give you tunnel vision and keep you in a loop that is hard to get out of, said Banich.

In a counseling setting, the findings suggest that to fully purge a problematic memory that keeps bubbling up, one might need to deliberately focus on it and then push it away.

Someday, the brain imaging technique could potentially be used during sessions as a sort of cognitive mirror to help people learn how to put destructive thoughts out of their minds.

Banich and Lewis-Peacock intend to study that next.

If we can get a sense of what their brain should look like if they are successfully suppressing a thought, then we can navigate them to a more effective strategy for doing that, said Lewis-Peacock. Its an exciting next step.

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Whether it's 2020 or Baby Shark: Study offers clues on how to stop thinking about it - CU Boulder Today

Individuals with high ADHD-traits are more vulnerable to insomnia – Newswise

Newswise Individuals with high ADHD-traits that do not meet the criteria for a diagnosis are less able to perform tasks involving attentional regulation or emotional control after a sleepless night than individuals with low ADHD-traits, a new study from Karolinska Institutet published inBiological Psychiatry: Cognitive Neuroscience and Neuroimagingreports.

While it can cause multiple cognitive impairments, there is considerable individual variation in sensitivity to the effects of insomnia. The reason for this variability has been an unresolved research question for long. In the present study, KI researchers investigated how sleep deprivation affects our executive functions, which is to say the central cognitive processes that govern our thoughts and actions. They also wanted to ascertain if people with ADHD tendencies are more sensitive to insomnia, with more severe functional impairments as a result.

ADHD (attention deficit hyperactivity disorder) is characterized by inattention, impulsiveness and hyperactivity; however, the symptoms vary from person to person and often also include emotional instability.

"You could say that many people have some subclinical ADHD-like symptoms but a diagnosis is only made once the symptoms become so prominent that they interfere with our everyday lives," says Predrag Petrovic, consultant and associate professor in psychiatry at the Department of Clinical Neuroscience at Karolinska Institutet, Sweden, who led the study along with Tina Sundelin and John Axelsson, both researchers at Karolinska Institutet and the Stress Research Institute at Stockholm University.

The study included 180 healthy participants between the ages of 17 and 45 without an ADHD diagnosis. Tendencies towards inattentiveness and emotional instability were assessed on the Brown Attention Deficit Disorder (B-ADD) scale.

The participants were randomly assigned to two groups, one that was allowed to sleep normally and one that was deprived of sleep for one night. They were then instructed to perform a test that measures executive functions and emotional control the following day (a Stroop test with neutral and emotional faces).

The researchers found that the sleep-deprived group showed worse performance in the experimental tasks (including more cognitive response variability). Moreover, people with high ADHD-traits were more vulnerable to sleep deprivation and showed greater impairment than those with low ADHD-traits.

The effects were also related to the most prominent type of subclinical ADHD-like symptom, in that after being deprived of sleep, the participants who displayed more everyday problems with emotional instability had larger problems with the cognitive task involving emotional regulation, and those who had more everyday inattention symptoms had larger problems with the non-emotional cognitive task.

"One of the reasons why these results are important is that we know that young people are getting much less sleep than they did just ten years ago," explains Dr Petrovic. "If young people with high ADHD-traits regularly get too little sleep they will perform worse cognitively and, what's more, their symptoms might even end up at a clinically significant level."

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The study was supported by grants from the Swedish Research Council, Forte (the Swedish Research Council for Health, Working Life and Welfare), Riksbankens Jubileumsfond, Karolinska Institutet, Region Stockholm, the Swedish Society of Medicine, the Sderstrm-Knigska Foundation and the Osher Centre for Integrative Medicine. The study is part of a doctoral project by Orestis Floros, who is also a psychiatrist specialising in ADHD.

Publication: "Vulnerability in executive functions to sleep deprivation is predicted by subclinical ADHD symptoms". Orestis Floros, John Axelsson, Rita Almeida, Lars Tigerstrm, Mats Lekander, Tina Sundelin, Predrag Petrovic.Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 17 December 2020, doi: 10.1016/j.bpsc.2020.09.019.

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Individuals with high ADHD-traits are more vulnerable to insomnia - Newswise