Neuroscience

Columbia Banking System Welcomes Laura Alvarez Schrag And Tracy Mack-Askew To Its Board Of Directors – PRNewswire

"We are pleased to welcome Ms. Alvarez Schrag and Ms. Mack-Askew to Columbia and look forward to benefiting from their expertise in the areas of organizational development, governance and operations," said Craig Eerkes, Chairman of the Board. "Both directors have a strong history of business and community leadership in the Northwest, and their appointment honors Columbia's tradition of naming community-based directors."

Laura Alvarez Schragis the President of Pondera Consulting and has extensive experience providing human resources, organizational and leadership development expertise to companies and nonprofits. In her prior role as Human Resources Manager at Hewlett-Packard, she implemented a comprehensive Talent Management system for global business units, led HR due-diligence for international acquisitions and developed diversity plans for global business units. Ms. Alvarez Schrag currently serves on the Board of Directors of Catholic Charities of Idaho, Bishop Kelly High School Governance Board and St. Alphonsus Community Board. She is a past board member of Human Resources Association of Treasure Valley and is a past president of Hispanic Cultural Center of Idaho and St. Paul's Catholic School Board. In 2014, she earned recognition as Idaho Young Mother of the Year from American Mothers Inc. and was named a Woman of the Year honoree in the Idaho Business Review. Ms. Alvarez Schrag is a resident of Nampa, Idaho and holds a Bachelor of Arts in Management and Organizational Leadership from George Fox University, an Associate of Applied Sciences in Business Administration from Lamson Business College, an applied Neuroscience and Brain Health Certification from the Neuroscience Academy and is an ACC Certified Executive Coach from the International Coaching Federation.

Tracy Mack-Askewis the General Manager-HD Vocational Platform Development of Daimler Trucks North America and has a depth of operations executive experience providing direction and oversight to cross-functional teams while increasing market share, reducing product complexity and ensuring excellence in design. Ms. Mack-Askew currently serves as a Finance Committee member on the Governing Board of Ronald McDonald House Charities of Oregon and Southwest Washington. She is Executive Sponsor of the Daimler African American Employee Resource Group and National Chair for the Policies and Procedures Committee of Jack and Jill of America Inc. In 2016, she was honored with an award for leadership in business and philanthropy from the Triad Business Journal's Women in Business Awards. Ms. Mack-Askew is a resident of Portland, Oregon and holds a Bachelor of Science in Mechanical Engineering from Rensselaer Polytechnic Institute, a Master of Science in Mechanical Engineering from Purdue University, a Master of Arts in Management from Harvard University and a Mergers and Acquisitions certificate from Harvard Business School.

About Columbia Headquartered in Tacoma, Washington, Columbia Banking System, Inc. (NASDAQ: COLB) is the holding company of Columbia Bank, a Washington state-chartered full-service commercial bank with locations throughout Washington, Oregon and Idaho. The bank has been named one of Puget Sound Business Journal's "Washington's Best Workplaces," more than 10 times and was recently honored as #1 in Customer Satisfaction with Retail Banking in the Northwest region by J.D. Power in the 2020 U.S. Retail Banking Satisfaction Study. Columbia was named the #1 bank in the Northwest on the Forbes 2020 list of "America's Best Banks" marking nearly 10 consecutive years on the publication's list of top financial institutions. More information about Columbia can be found on its website at http://www.columbiabank.com.

Columbia Bank received the highest score in the Northwest region of the J.D. Power 2020 U.S. Retail Banking Satisfaction Study of customer satisfaction with their own retail bank. Visit jdpower.com/awards.

Investor Relations Contact: [emailprotected]253-305-1921

Media Contact: Moira Conlon Financial Profiles, Inc. 310-622-8220 [emailprotected]

SOURCE Columbia Banking System Inc

http://www.columbiabank.com

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Columbia Banking System Welcomes Laura Alvarez Schrag And Tracy Mack-Askew To Its Board Of Directors - PRNewswire

Neuroscience

Make the Grade: Teens of the Month nominees – Akron Beacon Journal

Akron Beacon Journal

Andrew Greenwald,Stow-Munroe Falls City Schools, Stow-Munroe FallsHigh School, senior in culinary arts

Andrew is passionate about culinary arts and works extra hard to make sure that he excels in both lab and in theory.He just completed a project forhis capstonein which he created an entree to be served during lunch and for the school'stakeout menu.He arrived early in the morning and stayedto the end of the day to manage all aspects of the entree. At home, he works on furthering hisskills bypracticing culinary skills. He goes above and beyond to make culinary arts a program to be proud of.He is planning on attending a culinary arts college upon graduation.

Katelyn Vazquez, Akron Public Schools, Ellet Community Learning Center, senior

Katelyn selected the Criminal Justice Pathway/Community Health andSafety Academy while attending the University of Akron college credit plus program.Her strong work ethic and perseverancehaveenabled her to overcome many obstacles.She is an active participant in jazz band and drama productions. She serves as a student ambassador, belongs to the National Honor Society and is a member of the tennis team.

CassidyKarakis, Coventry Local Schools, Coventry High School, senior

Cassidy embodies the role of being a student athlete. She is athree-sportstandout in volleyball, basketballand softball. She has a 4.20 cumulative GPA while taking AP courses and CCP classes through the University of Akron. She also displays high character and isa leader and role model in the school and community. She has been an active member in Key Club and strives to make Coventry High School a special place for everyone. After graduation, she plans to attend Ohio State University and major in neuroscience.

Leslie Richard, Stow-Munroe Falls City Schools,Stow-Munroe Falls High School, senior in culinary arts

Leslieis a senior in culinary arts.Not only is she dedicated to the program, but she is an outstanding student who excels in baking, which is her passion.For her capstone, she is working with a culinary arts graduate on preparing cupcakes for her wedding.Leslie has earned herServSafeManager Certification and is also a student ambassador.Upon graduation, she planson furthering her education and focusing on baking and pastry.

Alaina Davis, Norton City Schools,Norton High School, senior

Alaina is an amazing young lady with such talent in so many realms. She is an outstanding athlete on the soccer field and is captain of the team, but her efforts go beyond her athletic talents. She was also elected the president of her senior class by her peers. In addition, Alaina is a dedicated student. She was chosen to be the president of Norton's Chapter of the National Honor Society. She also has a talent for the stage as she is the vice president for drama club. She is also the president of the speech and debate team. Although she is undecided on a college or major, school officials have no doubt that Alain will achieve anything she wants.

Michael Fuller, Springfield Local Schools, Springfield Junior/Senior High School, junior

Who wouldn't want a student like Michael Fuller in theclassroom? He's a pleasant 11th grade student enrolled in government, weight training, advanced chemistry, pre-calculus, advanced Englishand Spanish 4 with a GPA of 4.48 for the first nine weeks.Michael makes being a teacher an easy job. He has made the transition to remote learning seamless. He always attends Zoom sessions, turns in quality work, participates in discussions, and keeps up withall ofhis assignments. He has also navigated being an athlete during thepandemic andstill remainscompetitive. The Spartans are proud to call Michael quarterback on the football field and guard on the basketball court. Keep up the good work, Michael!

Victoria Fields, Springfield Local Schools, Springfield Junior/Senior High, junior

Springfield High School couldn't bemore proudof Tori Fields. She is a junior taking an exceedingly difficult load of classes and is excelling. Tori is enrolled in college-level English composition, government and politics, and medical terminology. In addition to those classes, she also takes advanced chemistry and pre-calculus. Her GPA for the first quarter is an impressive 4.5 and she maintains a cumulative GPA of 4.13 forall ofher high school career,As if Tori's academic accomplishments aren't enough, she is also an excellent athlete. She is a member of thegirlsgolf team andgirls basketballteam. School officialsare proud to call her a Spartan!

Modesty Jett-Casteel, Barberton City Schools, Barberton High School, student

Modesty Jett-Casteel is an outstanding young woman who is going above and beyond at Barberton High School. She excels in her classes and has made great strides in her academics. She maintains above a 3.5 GPA consistently and puts her all into her classwork. Modesty is also the first female captain of the BHS Overwatch Esports team and is one of our most skilled players. She recently was accepted to Kent State University where she intends to further her education, as well as continue participating in esports. School officials say she is one of the kindest teens they have met and she always works to make others feel welcome and accepted. Her positivity and willingness to work helpfoster a positive environment around her. Modesty also works with the Sparkle Effect, Barberton's Inclusive Cheer Squad, which works to bring together students with and without disabilities to practice and perform. She also volunteers to help manage the esports space at Barberton Public Library.

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Make the Grade: Teens of the Month nominees - Akron Beacon Journal

Neuroscience

Numerous Indian American STEM Researchers Named Fellows of American Association for the Advancement of Sciences – India West

The American Association for the Advancement of Sciences recently announced its group of 2020 AAAS Fellows, which included several Indian Americans and South Asian Americans.

Nearly 500 AAAS members earned the lifetime distinction, according to the associations news release.

AAAS Fellowsare elected each year by their peers serving on theCouncil of AAAS, the organizations member-run governing body. The title recognizes important contributions to STEM disciplines, including pioneering research, leadership within a given field, teaching and mentoring, fostering collaborations and advancing public understanding of science, the release said.

Among the Fellows were ShailajaK.Mani of theBaylor College of Medicinefor distinguished contributions to molecular and cellular neuroscience focused on molecular transcriptional regulation of steroid hormone receptors, signal transduction pathways and role of the microbiome; K. RajaReddyof Mississippi State Universityfor distinguished contributions to the field environmental plant physiology and agricultural systems modeling and applications; and SureshK.Alahariof Louisiana State University Health Sciences Center School of Medicine for distinguished contributions in cancer research and teaching, with a focus on signal transduction.

Additionally, SwathiArurof The University of Texas MD Anderson Cancer Center for discovery of Dicer1 phosphorylation by RAS/ERK signaling in Caenorhabditis elegans and implications for human fertility and cancer metastasis;

HitenD.Madhaniof U.C. San Francisco for distinguished contributions to the fields of molecular biology and genetics, particularly for developing fungal systems to uncover mechanisms of chromatin modifications and RNA splicing; TuliMukhopadhyayof Indiana University for distinguished contributions to the field of virology, particularly in structure and assembly of arthropod-borne viruses; RamaNatarajanof the City of Hope National Medical Center for distinguished contributions to the field of diabetes and its vascular complications, particularly for studies showing the roles of epigenetics and non-coding RNAs; and P. HemachandraReddyof Texas Tech University Health Sciences Center For pioneering contributions to the fields of Alzheimer's disease and mitochondrial neurobiology, particularly in discovering key role of mitochondria in neurodegenerative diseases and their treatment, were among the newly elected members

Additional members elected included RohitBhargavaof the University of Illinois at Urbana-Champaignfor pioneering contributions to chemical imaging, including infrared spectroscopic imaging theory, development of instrumentation, and its applications to realize all-digital cancer pathology; VishvaDixitof Genentech Inc.for pioneering studies defining the biochemical framework illuminating many of the key components of the cell death pathway; PrashantK.Jain of theUniversity of Illinois at Urbana-Champaign for distinguished contributions to the field of nanomaterial chemistry leading to atomistic understanding of artificial photosynthesis, multielectron transfer, catalysis and phase transitions; ManishChhowallaof the University of Cambridge (United Kingdom) for distinguished contributions to the field of two-dimensional materials, particularly using phase engineering to study their electronic, electrocatalytic and energy storage properties; VistaspM.Karbhariof TheUniversity of Texas at Arlington for distinguished contributions to the field of composites in civil infrastructure particularly in low-cost processing, durability and damage tolerance, rehabilitation and multi-threat mitigation; and SanjayKumarof U.C. Berkeley for distinguished contributions to the field of bioengineering, particularly the development of biomaterial and single-cell technologies to investigate mechanobiological signaling in health and disease.

SudipK.Mazumderof the University of Illinois at Chicago,for distinguished contributions to the field of multi-scale control and analysis of power-electronic systems; UdayB.Palof Boston University,for pioneering work providing novel materials-based solutions in the field of green engineering as applied to energy conversion and primary production of materials; HrideshRajanof Iowa State University,for distinguished contributions to data driven science, particularly to modularity and modular reasoning in computer software and the development of the Boa language and infrastructure; SureshK.Bhargavaof RMIT University (Australia),for an exceptional contribution to the fields of industrial chemistry and technology, particularly for molecular engineering, catalysis and nanotechnology bringing innovative solutions to the industries; MunindarP.Singhof North Carolina State University, for distinguished contributions to the field of computer science, particularly to foundations of multiagent systems and their applications in service-oriented computing, sociotechnical systems and governance; AnujSrivastavaof Florida State University,for distinguished contributions to the field of statistical pattern recognition, particularly for development of differential geometric approaches to statistical shape analysis; and SenduraiManiof The University of Texas MD Anderson Cancer Center,for demonstrating that cancer can make its own cancer stem cells and promote plasticity, resulting in metastasis and chemoresistance by activating latent embryonic epithelial-mesenchymal transition, were among the newly elected members.

Also named were D.NageshwarReddyof the Asian Institute of Gastroenterology (India),for pioneering work in gastroenterology, particularly advances in therapeutic pancreatic biliary endoscopy and innovations in transgastric endoscopic surgery; and for service to international gastroenterology societies; Debomoy (Deb)K.Lahiriof Indiana University, for distinguished contributions to the field of molecular and translational neuroscience, particularly roles of epigenetics and microRNA on neuronal physiology and eventually treating human neurodegenerative diseases; NiraoM.Shahof Stanford University,for exceptional contributions to the field of behavioral neuroscience, particularly the dissection of neural circuits and transcriptomics controlling social behaviors.

Also named Fellows were M.N.V.RaviKumarof Texas A&M University,for distinguished contributions to the field of drug delivery, particularly the next-generation polyesters and non-competitive targeting strategies are of profound significance to the human health; and BulbulChakrabortyof Brandeis University, for important theoretical contributions to diverse areas of condensed matter physics, particularly disordered systems including frustrated magnets and granular materials.

TalatShahnazRahmanUniversity of Central Florida, for distinguished contributions to computational and theoretical nanoscience, in predictions of chemical, vibrational, and structural properties of low-dimensional systems, together with diversity in STEM; NandiniTrivediof The Ohio State University,for her contributions to the theoretical understanding of quantum matter, characterized by innovative use of quantum Monte Carlo techniques and close experimental collaborations; RamananLaxminarayanof the Center for Disease Dynamics, Economics & Policy/Princeton University,for distinguished contributions to the field of economic epidemiology, with particular reference to the spread and control of antimicrobial resistance; and SudiptoBanerjeeof UCLA,for innovative contributions to Bayesian methodology with focus on spatially indexed information, for high-impact applications, for educational and mentoring excellence, professional service and academic administration were named.

A virtual induction ceremony for the 489 newly elected Fellows will take place on Feb. 13, 2021, the Saturday following the AAAS Annual Meeting.

The honorees will receive official certificates and rosette pins in gold and blue, colors symbolizing science and engineering, by mail.

The tradition of electing AAAS Fellows began in 1874. Since then, the recognition has gone to thousands of distinguished scientists, such as inventor Thomas Edison, elected in 1878, sociologist W. E. B. Du Bois (1905), anthropologist Margaret Mead (1934), computer scientist Grace Hopper (1963), physicist Steven Chu (2000), and astronaut Ellen Ochoa (2012). The 2020 group contains members of each ofAAASs 24 sections, the release notes.

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Numerous Indian American STEM Researchers Named Fellows of American Association for the Advancement of Sciences - India West

Neuroscience

Neuroscience Market 2020: COVID19 Impact on Industry Growth, Trends, Top Manufacturer, Regional Analysis and Forecast to 2027 – The Monitor

New Jersey, United States,- The in-depth research report on Neuroscience Market added to its huge repository by Verified Market Research provides brilliant and comprehensive market research. The report offers an in-depth study of key market dynamics including growth drivers, restraints, and opportunities. It mainly focuses on current and historical market scenarios. It includes market competition, segmentation, geographic expansion, regional growth, market size, and other factors. The Neuroscience research study is sure to benefit investors, market players and other market players. You will gain an in-depth understanding of the global market and industry.

This report focuses on Neuroscience market trends, future forecast, growth opportunities, key end-user industries and market players. The aim of the study is to present the most important developments of the market in the world.

the Global Neuroscience Market was valued at USD 27.27 Billion in 2019 and is projected to reach USD 36.65 Billion by 2027, growing at a CAGR of 3.74% from 2020 to 2027.

The following Manufacturers are covered in this report:

Neuroscience Market Report Contains:

Market Scenario Growth, Constraints, Trends, and opportunities Segments by value and volume Status of supply and demand Competitive analysis Technological innovations Analysis of the value chain and investments

This is an up-to-date report covering the current impact of COVID-19 on the market. The coronavirus pandemic (COVID-19) has affected all aspects of life around the world. This resulted in several changes in market conditions. The rapidly changing market scenario along with the initial and future assessment of the impact is covered in the report. The report discusses all major aspects of the market with expert opinions on the current state of the market as well as historical data. This market report is a detailed study of growth, investment opportunities, market statistics, growing competitive analysis, key players, industry facts, key figures, sales, prices, revenue, gross margins, market share, business strategies, major regions, demand and developments.

The report further studies the segmentation of the market based on product types offered in the market and their end-use/applications.

Global Neuroscience Market by Type

Global Neuroscience Market by Application

Furthermore, the market research industry provides a detailed analysis of the Neuroscience market for the estimated forecast period. The market research provides in-depth insights into the various market segments based on end-use, types, and geography. One of the most important characteristics of a report is the geographic segmentation of the market which includes all the key regions. This section mainly focuses on various developments in the region including the main development and how these developments will affect the market. Regional analysis provides in-depth knowledge of business opportunities, market status and forecast, possibility of generating sales, regional market by different end-users along with future types and forecast for the coming years.

Geographic Segmentation

The report offers an exhaustive assessment of different region-wise and country-wise Neuroscience markets such as the U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc. Key regions covered in the report are North America, Europe, Asia-Pacific, Latin America, and the Middle East and Africa.

The report includes:

Market overview Complete market analysis Analysis of the latest market developments Events of the market scenario in recent years Emerging and regional markets Segmentations up to the second and/or third level Historical, current and estimated market size in terms of value and volume Competitive analysis with an overview of the company, products, sales, and strategies. impartial market assessment Strategic recommendations to increase the presence in the business market

The study analyzes numerous factors influencing supply and demand in the Neuroscience market and further assesses market dynamics that boost the market growth during the forecast period. Furthermore, the Neuroscience market report offers a comprehensive analysis of the SWOT and PEST tools for all major regions such as North America, Europe, Asia Pacific, Middle East and Africa. The report offers regional expansion of the industry with product analysis, market share, and brand specifications. Furthermore, the Neuroscience market research provides a comprehensive analysis of the political, economic, and technological factors which are driving the market growth in these economies.

Some Points from Table of Content

1. Study coverage2. Summary3. Neuroscience Market Size by Manufacturer4. Production by region5. Consumption by region6.Neuroscience Market Size by Type7. Neuroscience Market size according to application8. Manufacturer profiles9. Production forecasts10. Consumption forecasts11. Analysis of customers upstream, industrial chain and downstream12. Opportunities and challenges, threats and influencing factors13. Main results14. Appendix

Verified Market Intelligence is a BI enabled database service with forecasted trends and accurate market insights on over 20,000+ tracked markets helping organizations globally with their market research needs. VMI provides a holistic overview and global competitive landscape with respect to Region, Country, Segment and Key players for emerging and niche markets.

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Our 250 Analysts and SMEs offer a high level of expertise in data collection and governance use industrial techniques to collect and analyze data on more than 15,000 high impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise, and years of collective experience to produce informative and accurate research.

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Neuroscience Market 2020: COVID19 Impact on Industry Growth, Trends, Top Manufacturer, Regional Analysis and Forecast to 2027 - The Monitor

Immunology

Assistant/Associate Professor in Immunology job with UNITED ARAB EMIRATES UNIVERSITY | 239789 – Times Higher Education (THE)

Job Description

The Department of Medical Microbiology & Immunology, College of Medicine and Health Sciences (CMHS), UAE University, seeks candidates for a faculty position at the rank of Assistant/Associate Professor in Immunology. Outstanding candidates working in all areas of immunology are invited to apply. We are particularly looking for an innovative investigator with a strong research productivity who has an established, or a clear potential to establish, an independent research program.

Candidates with experience in translational immunology research and with a strong background in computational and systems biology, genomics or bioinformatics will be preferred. Screening of applications will continue until the position is filled. The College of Medicine operates an internationally recognized, integrated, problem/team-based learning curriculum and provides excellent research facilities. English is the language of instruction. Areas of research within the Department include integrative immunology approaches to study cancer immunity and immunotherapy, mechanisms of autoimmune disorders, molecular epidemiology of human bacterial pathogens and antibiotic resistance, development of retroviral vectors for gene therapy, EBV and its role in the pathogenesis of human diseases and public health, neuroimmune regulatory pathways, and host-pathogen interactions.

Minimum Qualification

The successful candidate must have a PhD or MD/PhD from an accredited institution. The candidate should have a strong track record of research in immunology. It is expected that the appointee will also have experience in teaching medical and postgraduate students. Importantly, candidates must demonstrate the potential to establish an independent and sustained research program in their area of expertise and be able to obtain peer-reviewed internal and external funding.

Preferred Qualification

As above.

Division College of Medicine&Health Sciences

Department Microbiology - (CMHS)

Job Close Date open until filled

Job Category Academic - Faculty

Salary 30000-40000 UAE Dirhams per month, based on experience

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Assistant/Associate Professor in Immunology job with UNITED ARAB EMIRATES UNIVERSITY | 239789 - Times Higher Education (THE)

Immunology

Lasting immunity against Covid-19 found after mild or asymptomatic infection: Study – Hindustan Times

Scientists have found evidence of protective immunity against Covid-19 in people up to four months after mild or asymptomatic coronavirus infection, providing hope for the long-lasting efficacy of vaccines.

The researcher, including those from Queen Mary University of London analysed antibody and T cell responses in 136 healthcare workers in the UK, who had mild or asymptomatic Covid-19 infection dating back to March.

The study, published in the journal Science Immunology, found that 89 per cent of healthcare workers analysed carried neutralising antibodies 16-18 weeks after infection.

The team, also involving researchers Imperial College London and University College London, UK, found most workers also had T cells capable of recognising multiple different parts of the virus.

However, they noted that the two responses did not always persist in harmony, with some individuals showing T cell immunity but no evidence of antibodies, and vice versa.

Our study of SARS-CoV-2 infection in healthcare workers from London hospitals reveals that four months after infection, around 90 per cent of individuals have antibodies that block the virus, Joseph Gibbons, a Postdoctoral Research Assistant at Queen Mary, said.

Even more encouragingly, in 66 per cent of healthcare workers we see levels of these protective antibodies are high and that this robust antibody response is complemented by T cells which we see reacting to various parts of the virus, Gibbons said.

Describing the finding as good news, he explained that if someone has been infected with the coronavirus, there is a good chance that they will have developed antibodies and T cells that may provide some protection in case they encounter the virus again.

Much of the debate on protective immunity has focussed on the different roles of B cells, which make antibodies, and T cells, white blood cells which help protect from viruses, including direct killing.

The latest study found that while protective antibody responses were usually complemented by a T cell response, over half of the healthcare workers had different antibody and T cell responses.

The workers did not produce a T cell response specific to proteins found on the outer layer of the SARS-CoV-2 virus.

The research also found that T cell responses tended to be higher in those with the classic, defining symptoms of Covid-19, while asymptomatic infection resulted in a weaker T cell immunity than symptomatic infection, but equivalent neutralising antibody responses.

The new study also provides reassurance for vaccination efforts, suggesting that even following mild infection, individuals carry antibody and T cell immunity to many parts of the virus, known as epitopes.

The researchers noted that while new variants are appearing, the changes to the virus dont necessarily occur within these epitopes so it is hoped the vast majority of immune recognition can likely continue unperturbed.

Our study in asymptomatic and mild cases gives a positive insight into the durability of immunity to SARS-CoV-2 after four months of infection, Corinna Pade, a Postdoctoral Research Scientist at Queen Mary, said.

The researchers noted that it is an important finding as mild or even no symptoms of Covid-19 are very common and representative of most infections in the community.

Such abundant immune responses also give hope for the long-lasting efficacy of vaccines, Pade added.

(This story has been published from a wire agency feed without modifications to the text.)

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Lasting immunity against Covid-19 found after mild or asymptomatic infection: Study - Hindustan Times

Immunology

Secondary Bloodstream Infections Associated With Severe COVID-19 and Worse Health Outcomes – SciTechDaily

People with severe COVID-19 who had secondary bloodstream infections were sicker, had longer hospital stays and worse health outcomes, Rutgers study finds.

People with severe COVID-19 and a secondary blood infection were significantly sicker upon hospital admission, had longer hospital stays, and poorer outcomes, according to a Rutgers study.

The study, published in the journal Clinical Infectious Diseases, is the first to assess the microbiology, risk factors, and outcomes in hospitalized patients with severe COVID-19 and secondary bloodstream infections.

The researchers looked at 375 patients diagnosed with severe COVID-19 from March to May 2020. Of that group, they sampled 128 cases that had secondary bloodstream infections, 92 percent of which were bacterial infections.

These patients were more likely to have altered mental status, lower percent oxygen saturation, septic shock and to be admitted to the intensive care unit compared to those without bloodstream infections, said co-lead author Pinki Bhatt, an assistant professor at Rutgers Robert Wood Johnson Medical Schools Division of Allergy, Immunology and Infectious Disease.

The researchers also found that patients who needed more advanced types of supplemental oxygen upon hospital admission had higher odds of secondary bloodstream infections.

The in-hospital mortality rate for these patients was more than 50 percent, but the study reported these deaths were associated with, not caused by, the condition.

According to the study, infections in COVID-19 patients may have contributed to the severity of illness or it may reflect other underlying physiological and immunological complications of COVID-19.

The study showed that the most common cause of secondary blood stream infections was unknown or not determined followed by central-line associated bloodstream infection as the most common presumed source.

The study found that 80 percent of all the patients in the study received antimicrobials at some point during hospitalization, including those who did not have bloodstream infections. This likely reflects clinicians inclination to administer antimicrobials given the limited information on the natural course of this novel disease, Bhatt said. She noted that further studies are needed to better understand when to suspect and treat empirically for secondary bloodstream infections in severe COVID-19.

Reference: Risk Factors and Outcomes of Hospitalized Patients With Severe Coronavirus Disease 2019 (COVID-19) and Secondary Bloodstream Infections: A Multicenter Case-Control Study by Pinki J Bhatt, Stephanie Shiau, Luigi Brunetti, Yingda Xie, Kinjal Solanki, Shaza Khalid, Sana Mohayya, Pak Ho Au, Christopher Pham, Priyanka Uprety, Ronald Nahass, Navaneeth Narayanan, 20 November 2020, Clinical Infectious Diseases.DOI: 10.1093/cid/ciaa1748

Other Rutgers authors include Stephanie Shiau, Luigi Brunetti, Yingda Xie, Kinjal Solanki, Shaza Khalid, Sana Mohayya, Pak Ho Au, Christopher Pham, Priyanka Uprety and Ronald Nahass.

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Secondary Bloodstream Infections Associated With Severe COVID-19 and Worse Health Outcomes - SciTechDaily

Immunology

Covid jab supply will be biggest cause of delay in Irish rollout as Pfizer dont have enough to go around, e – The Irish Sun

THE supply and availability of the Covid-19 vaccine will be the biggest cause of delays in Ireland's rollout, an immunologyexpert said.

Professor of Experimental Immunology at Trinity College Dublin, Kingston Mills, said Pfizer do not have enough of the jab to go around, and are cranking up manufacturing to meets countries' needs.

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Ireland's first doses of the jab will be administered this week at four hospitals, with a roll-out beginning nursing homes after.

Health Minister Stephen Donnelly has predicted that Ireland will see up to 20,000 people vaccinated a week from early January on.

Professor Mills said supply and availability of doses will be the largest challenge in Ireland's roll-out.

Speaking on Newstalk's Late Breakfastwith Mark Cagney, Prof Mills said: "I think what's going to delay the rollout is the supply and availability of vaccine.

We have currently got quite a small number of doses, only 10,000, so we are going to get through that quite quickly.

"So the delay in getting into health care workers and nursing homes is supply.

Pfizer just dont have enough of this vaccine to go around for all the countries that want it yet.

"They are going to be cranking up the manufacturing now and hopefully that will be solved in the weeks and months ahead.

According to Prof Mills, transparency is key in the vaccine roll-our in order to ensure successful uptake.

He said: There are huge benefits that is the thing that has to be said with these vaccines.

90 per cent of people 95 per cent in the cases of Pfizer will not get Covid if they are vaccinated. That is what the clinical trials show so that is a huge, huge benefit.

There were some side-effects. People got some injection site reactions; some people got a slight fever. These are all transient events that are often association with vaccination.

They need to be spelled out to the public and transparency is key to all of this.

"Making sure that everyone knows about any potential issues and then if people get a slight reaction, they will know that was common enough based on the clinical trial and it shouldnt be a problem.

Meanwhile, Tanaiste Leo Varadkar has said Covid-19 restrictions over the coming weeks must be "sustainable" and may be in place for a "long period".

TheFine Gaelleader explained that the availability of the vaccine has "changed things" in regards to reopening the country.

And he said restrictions should be in place until the vulnerable are vaccinated.

Varadkar told RTE Radio One's Morning Ireland: "The availability of the vaccine does change things now.

"We can actually now foresee the point in which well have vaccinated those most at risk, the very elderly, people in residential care and healthcare workers.

"I think there is a case for saying that restrictions that are in place should stay in place until thats done.

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"But that also, needs to then be reflected in the kind of restrictions we put in place because they need to be sustainable for a long period.

"Theyre not just for three or four weeks."

Varadkar said that the Cabinet plan to review the restrictions on January 12 and that has not changed.

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Covid jab supply will be biggest cause of delay in Irish rollout as Pfizer dont have enough to go around, e - The Irish Sun

Anatomy

Anatomy of Jayson Tatums missed game winner vs. Pacers – Celtics Blog

If youve become a fan of Brad Stevens after timeout wizardry, you know that so much happens before the inbounds pass. Al Horfords game winner in Game 3 against the 76ers in 2018 is the perfect example.

For Stevens, its not just about getting the ball in your best shooters hands at the end of the game. He tries to leverage everything against an opponents defense: tendencies, switching schemes, footwork, misdirection, etc. On Sunday night against the Pacers, Stevens had another chance to draw up something special.

Coming out of the timeout, you can see Pacers head coach Nate Bjorkgren motion to Malcolm Brogdon to switch the coverage. Initially, Indiana had Doug McDermott on Marcus Smart, but Bjorkgren calls for Aaron the tougher and rangier Justin Holiday to cover Smart and the less athletic McDermott to stick Payton Pritchard. For lack of a better word, if Smart is part of the inbound action, its going to be funky. Best to have one of your better defenders involved.

Theres a fun little wrinkle right before referee Kane Fitzgerald gives Grant Williams the ball. Check out the weak side with Pritchard and Jaylen Brown in the corner. A moment before starting the five-second count, Brown takes a few steps to his left, drawing the attention of T.J. Warren and McDermott. Its a tiny adjustment that means nothing, but it draws the attention of the defenders and that could be enough to show their hand on what kind of coverage theyre running or provide a small crack to take advantage of.

Heres the meat of the play. In his post game presser, Stevens said, we were looking for a little bit of action off of an entry where they were denying and it went to Tatum at the top.

Bjorkgren guessed right. The outcome of the play was Tatum flashing between the circles after a Marcus Smart down screen, but I dont think that was the first option. The little bit of action that Stevens is referencing is the two-man game between Smart and Tatum. Even before Grant touches the ball, Smart is telegraphing down screen the entire time. My guess is that Stevens and the Celtics were hoping for a switch with Holiday trailing Tatum to midcourt. If that had happened, Smart would have had Brogdon sealed on his back in the low post. Indiana was in the penalty and Smart has a knack of drawing contact on the block. Smart could have also cleared a driving lane for Tatum, too.

Unfortunately, Brogdon decides to fight through the screen and Domantas Sabonis does a great job pushing the action away from the basket. Smart is so far away from the restricted area and with the taller Holiday on him, its far from an advantageous mismatch.

Instead, Tatum took the same step back 3 that won the opener over Giannis Antetokounmpo with a different result.

We had that as an option (Tatum in isolation) and then Grant slipped out of that thing and Tatum got separation, but thats obviously a tough shot. But, he made it the other day, Steven said of the final shot, but frankly, he sounded resigned with the analysis. One of our best players and certainly one of the guys you want to have the ball with the game on the line in the league had the ball so that was a positive, I guess.

Tatum shouldered much of the responsibility for the loss. Thats a shot I take a lot and can hit, but you want to put pressure on the refs and defense in that situation, he admitted. It wasnt the exact play we drew up, but I should have put more pressure on them. Thats on me in that situation. I take full blame.

Sure, Tatum could have driven the ball and forced the issue. Its what stars do in that situation. However, by all indications, this was a busted play that just didnt break right in the end. Theyll get another crack against the Pacers on Tuesday night.

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Anatomy of Jayson Tatums missed game winner vs. Pacers - Celtics Blog

Anatomy

The Anatomy of a Wild Finish – DolphinMaven

Ryan Fitzpatrick's "no-look pass" that helped the Miami Dolphins pull out their incredible victory at Las Vegas will go down as one of the most memorable plays in franchise history.

It's a play that deserves a deeper look, particularly considering all the layers involved, including an officiating mistake, a pre-planned strategy by the Dolphins, a controversial Raiders decision and, of course, help from a baffled Raiders secondary.

The record will show a 34-yard completion from Fitzpatrick to Mack Hollins plus a 15-yard facemask penalty on defensive end Arden Key that moved the ball from the Dolphins 25-yard line to the Raiders 26 and set up Jason Sanders' 44-yard game-winning field goal to secure Miami's 26-25 victory.

The Dolphins had the ball at their 25-yard line down by two with 19 seconds left and no timeouts remaining, and ESPN gave the Raiders a 99.9 percent win probability before "The Pass."

It was the 5,053th regular season pass of Fitzpatrick's NFL career and he said after the game his might have been the biggest of his career and we'll forgive him if he became a prisoner of the moment.

"I think the odds were pretty low there of us to be able to complete something with the proper yardage and not have to throw a Hail Mary but actually kick a field goal," Fitzpatrick said. "I didnt know that it was complete. As you guys saw, my facemask was getting pulled and my head was getting ripped off. I turned around to say, Hey, facemask, just to make sure they saw it. I think Jesse Davis, or maybe Myles (Gaskin) had to tell me that it was complete, but I didnt know that we completed it.

But before that play happened, there were a lot of interesting things that set the stage.

Of course, the Dolphins needed the miracle largely because of a fringe defensive pass interference penalty on cornerback Byron Jones. While, yes, Jones made contact with wide receiver Nelson Agholor, he hardly impeded his ability to make the catch, and it also was not as much contact as when Agholor pushed off on his 85-yard touchdown a few minutes earlier.

And that's not just us saying it.

That call put the Raiders in position to take the lead after they trailed 23-22 because kicker Daniel Carlson missed an extra-point attempt after Agholor's long touchdown.

And this is where we get to more interesting stuff.

We'll start with the officiating error.

On the first play after the two-minute warning, Josh Jacobs rushed for 2 yards to make it third-and-1 at the Dolphins 13-yard line. Miami called their second timeout on the play, though Raiders tackle Trent Brown was injured during the play and trainers came out to tend to him.

This is where the officiating mistake came in because the Dolphins should have gotten their timeout back because of the injury on the play, and it's the Raiders who should haven been charged with a timeout.

That extra timeout the Dolphins should have had would have made a big difference in the end and would have changed the way both teams played at the end of that possession.

Because the Dolphins were out of timeouts, the Raiders focused more on killing as much of the clock as possible even if it meant settling for a field goal and a two-point lead instead of trying to score a touchdown that would have made it 28-23 and would have led to a two-point conversion attempt.

The reason Raiders coach Jon Gruden chose that route is because he had flashbacks of Patrick Mahomes driving down the field for a game-winning touchdown after he left him too much time on the clock.

Again, would Gruden have gone for the touchdown if not for the missed PAT because then a simple extra point would have given them a seven-point lead?

In any event, the Dolphins were aware of what the Raiders were trying to do, which is why you saw defenders getting out of the way of Jacobs on the second-and-goal run from the 6. Jacobs, though, didn't want to score, which is why he slid at the 1-yard line.

"They were trying not to score, (and) yeah, we were trying to let them score," head coach Brian Flores. "At the end of the day, they were OK with taking the lead with 19 seconds, which obviously theres a high probability of winning given that situation, and we made a play at the end, a couple plays at the end. And again, like games in this league, they come down to one or two plays, but strategy-wise, I understand why they did what they did.

In essence, the Raiders preferred being up two with 19 seconds left instead of, say, being up six or seven with around a minute left.

Again, if not for the timeout mistake, it's almost certain the Raiders would have gone for the touchdown instead of opting to go up by two with around a minute left.

That obviously would have presented a different challenge for the Dolphins, who would have needed to drive 75 yards for a game-winning or game-tying touchdown depending on the two-point conversion attempt.

As it was, the Dolphins already were facing what seemed to be an insurmountable task.

Getting his facemask yanked from the side made it a pretty impressive throw by Fitzpatrick, whose pass wasn't necessarily a work of art but still got to a wide open Hollins near the sideline because the Raiders secondary somehow failed to account for him.

Even though Hollins rushed to get out of bounds, that became unnecessary because of the penalty called on the Raiders.

On the other end, Fitzpatrick had just added to the legend of "FitzMagic."

Even the king of the no-look pass had to acknowledge the brilliance of the moment.

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The Anatomy of a Wild Finish - DolphinMaven