Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts – Science

1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.

2Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.

4Biological and Medical Informatics Graduate Program, University of California, San Francisco, San Francisco, CA, USA.

5Integrative Program in Quantitative Biology, University of California, San Francisco, San Francisco, CA, USA.

6Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.

Follow this link:
Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts - Science

Artificial Photosynthesis Market SWOT Analysis, by Key Players: Department of Genetics, Cell Biology, and Development, University of Minnesota,…

A new Artificial Photosynthesis market research report highlighting quintessential facets of the market such as impact of the global pandemic and followed by a tentative profit generation graph to suit reader interests and justify future centric business decisions has been recently compiled in the growing data archive. Further in the report progression graph this well-conceived report highlighting vital milestones of the market also critically focuses on novel ways for current opportunity enhancement, besides unravelling novel ways to identify untapped ones. Thorough research initiatives directed by seasoned in-house researchers as well as business specialists suggest that Artificial Photosynthesis market like its previous growth performance in the historical timespan is likely to continue its growth strides, registering a hefty y-o-y growth valuation of xx% through the market assessment time span, 2020-25, suggesting optimistic revenue streams through the end of the assessment duration.

Request a sample of this report @ https://www.orbisresearch.com/contacts/request-sample/5250231?utm_source=vkpatil

Besides identifying viable growth opportunities, this section of the report also gauges into prevalent market manacles and hindrances that interfere with normal functionality. The report also comprises of in-depth assessment of trends and novel business strategies honed by leading players representing competition terrain.

The Artificial Photosynthesis market report is a highly advanced and dependable guide to understand market limitations in terms of challenges and restraints, besides also highlighting potent drivers and growth propellants that enable growth maximization and revenue stability.

Manufacturer Detail:

Department of Genetics, Cell Biology, and Development, University of MinnesotaDepartment of Chemistry, University of Illinois Urbana-ChampaignDepartment of Chemistry, University of CambridgeDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial MicrobiologyUniversity of Bordeaux, CNRS, Centre de Recherche Paul PascalInstitut Universitaire de FranceResearch Center for Solar Energy Chemistry, and Division of Chemical Engineering, Graduate School of Engineering Science, Osaka UniversityEnergy Materials Laboratory, Korea Institute of Energy ResearchJoint Center for Artificial Photosynthesis, Lawrence Berkeley National LaboratoryTechnical Chemistry, Department of Chemistry, Chemical-Biological Centre, Ume UniversityCatalysis Division, National Chemical Laboratory

Read complete report at @ https://www.orbisresearch.com/reports/index/global-artificial-photosynthesis-market-report-2020?utm_source=vkpatil

Vendor Profiling Guide

The pricing mix and the sales caliber of each of the product has been gauged minutely.

The competition hierarchy, highlighting astute players in the space have been optimally discussed in the report.

The application scope of the products and thorough alterations of the products aligning with industry needs have been highlighted.

Major regions with country specific demonstration of manufacturing activities as well as promotional activities have also been inscribed in the report.

By Type

Suspended Nanopowder PhotocatalystsPhotovoltaic Cell-driven ElectrolysersPhotoelectrochemical Cells (PECs)

By Application

IndustrialMachinery & EquipmentAutomotiveAerospace & Defense

Segment Classification: Global Artificial Photosynthesis Market

This well composed, balanced and unbiased representation of global Artificial Photosynthesis market documentation nurtures core developments across local, national and regional connotations to unravel every growth aspect.

Distinct information representing total revenue generation, growth rate determination, prevalent across specific growth hubs have been discussed meticulously to understand performance across borders through the assessment time frame.The products and product-based application have been represented in segment stratification section of the report, also denoting pricing strategies, aligning with buyer potential and industry specificities.

The products mentioned in the segmentation section of the report also take into account other vital points such as sales pattern and application scope.

Research initiatives also suggest that in the coming times, the Artificial Photosynthesis market is also likely to show optimistic signs of growth restoration, emerging from detrimental aftermath of COVID-19 impact.

Make an enquiry of this report @ https://www.orbisresearch.com/contacts/enquiry-before-buying/5250231?utm_source=vkpatil

About Us :

Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements. We have vast database of reports from the leading publishers and authors across the globe. We specialize in delivering customized reports as per the requirements of our clients. We have complete information about our publishers and hence are sure about the accuracy of the industries and verticals of their specialization. This helps our clients to map their needs and we produce the perfect required market research study for our clients.

Contact Us :

Read the original here:
Artificial Photosynthesis Market SWOT Analysis, by Key Players: Department of Genetics, Cell Biology, and Development, University of Minnesota,...

Global Regenerative Medicine Market Insights, Overview, Analysis and Forecast 2022 NeighborWebSJ – NeighborWebSJ

Regenerative Medicine Market Major Players:

Players active in the global regenerative medicine market include Osiris Therapeutics, Cook Biotech, Organogenesis, Baxter International, Inc., Stryker and RTI surgical, LifeSciences, CryoLife, Advanced Cell Technology, Sanofi, BioMimetic Therapeutics, Medtronic, StemCellsInc, and LifeCell Kinetic Concepts, among others.

ALSO READ :https://sapanas.tumblr.com/post/631130245458739200/regenerative-medicine-market-competitive-analysis

Regenerative Medicine Market Outlook

Global regenerative medicine market is growing continually, witnessing a massive uptake. Market growth primarily attributes to the increasing advancement in healthcare technology and the growing prevalence of chronic diseases. Besides, improvements in the field of regenerative medicine and stem cell technology drive the growth of the market excellently.

Moreover, the rising uptake of therapeutics such as stem cell biology, cellular therapy, tissue engineering in applications, including cord blood, oncology, urology, orthopedics, neurology, dermatology, and others accelerate the market growth. According to Market Research Future (MRFR), the global regenerative medicine market is poised to grow at 25.4% CAGR throughout the forecast period (2016 2022).

ALSO READ :https://yarabook.com/read-blog/138540

Additionally, the rising uptake of stem cell & tissue engineering processes in the treatment of health issues ranging from orthopedics, musculoskeletal & spine, dental, and skin/integumentary to cancer, neurology, and cardiology substantiate the market growth. Furthermore, the increasing rate of road accidents, injuries, and trauma cases drive the market exponentially, driving the demand for transplants & surgical reconstruction procedures.

On the other hand, factors such as the lack of awareness, skilled professionals, and stringent regulatory policies are projected to act as significant impeders for market growth. Nevertheless, funding support for the development of regenerative medicines would support the growth of the market throughout the predicted period. Also, widening application areas of regenerative medicines in the field of stem cell reconstructive and skin grafting would increase the market growth.

Global Regenerative Medicine Market Segments

The analysis is segmented into four dynamics;

By Material: Synthetic Materials, Genetically Engineered Materials, Pharmaceuticals, and others.

By Therapy: Stem Cell Biology, Cellular Therapy, Tissue Engineering, and others.

By Application: Cord Blood, Oncology, Urology, Orthopedics, Neurology, Dermatology, and others.

ALSO READ :http://www.marketwatch.com/press-release/fram-market-2021-industrytrends-opportunities-market-volume-competitive-landscape-possible-challenges-and-forecast-to-2025-2021-01-06

By Regions: Americas, Europe, Asia Pacific, Middle East & Africa, and Rest-of-the-World.

Regenerative Medicine Market Regional Analysis

North America is projected to continue dominating the globalregenerative medicine marketthroughout the forecast period. In 2015, North America accounted for more than 44% of the overall market share. This huge market growth attributes to the presence of a large number of major players and pharma & biotechnology companies. Moreover, huge investments made by public & private organizations drive the regenerative medicine industry in the region.

Besides, the rising prevalence of chronic diseases and orthopedic issues and increasing clinical trials to evaluate the therapeutic potential of products foster regional market growth. Also, the well-spread awareness towards the therapeutic potency of regenerative medicines impacts the market growth positively. The North American regenerative medicine market is expected to grow at a robust CAGR of 22.3% over the review period.

Europe stands second in the global regenerative medicine market. Factors such as the increasing per capita healthcare expenses and penetration of healthcare sectors in the region boost the market growth. Additionally, the rising government support and R&D funding in the life science developments substantiate the regional market growth. Markets in the UK, Germany, and France, contribute to the regional market majorly. The European regenerative medicine market is estimated to grow at 22.5% CAGR during the assessment period.

ALSO READ :http://www.marketwatch.com/press-release/m2m-communication-market-demand-to-rise-amid-industrial-automation-industry-analysis-with-business-trends-covid19-outbreak-competitor-strategyforecast-to-2023-2021-01-05

The Asia Pacific regenerative medicine market has emerged as a rapidly growing market. Factors such as the large advances in biotechnology and increasing government support for R&D are fostering the growth of the regional market. Regenerative medicine markets in highly populated countries such as China, India, and Japan support the regional market growth excellently, heading with huge technological advances. The APAC Regenerative Medicine market is predicted to demonstrate huge growth potential.

Global Regenerative Medicine Market Competitive Analysis

The well-established regenerative medicine market appears to be highly competitive with the presence of several notable players. To gain a larger competitive advantage, market players incorporate strategic initiatives such as mergers & acquisitions, expansions, and product/technology launch. Also, they make substantial investments to drive R&D to develop their capabilities and to expand their global footprints. Simultaneously, R&D funding programs initiated by the governments to enhance regenerative medicine capabilities are offering high growth potential. This is further going to attract several new entrants to the market and intensify the market competition further.

Regenerative Medicine Industry/Innovations/Related News:

March 15, 2020 - Research team at the University of Sheffield published their study on stem cell mutations that could improve regenerative medicine in the magazine Stem Cell Reports. Their study gives new insights into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring. It also suggests ways to reduce the likelihood of variations occurring in these cells when cultured. There is considerable interest in using Pluripotent stem cells to produce cells that can replace diseased or damaged tissues in applications referred to as regenerative medicine.

ALSO READ :http://www.marketwatch.com/press-release/waste-to-energy-market-share-size-key-players-regional-study-and-forecast-2024-2020-12-30

https://neighborwebsj.com/

See the original post:
Global Regenerative Medicine Market Insights, Overview, Analysis and Forecast 2022 NeighborWebSJ - NeighborWebSJ

Global Live Cell Imaging Market Size is Expected to reach USD 3529.26 Million by 2025 and Registeri – PharmiWeb.com

GlobalLive Cell ImagingMarket Research Report and Forecast 2020-2025is the latest report byFior Marketswhich is the fastest growing market research company. The report provides a comprehensive scope of the market which includes future supply and demand scenarios, changing market trends, high growth opportunities, and in-depth analysis of the future market prospects. The report features real-time developments in the globalLive Cell Imagingmarket encompasses a highly structured and comprehensive outlook of the market. It shows market types and applications that are categorized as ideal market segments. The report covers the competitive data analysis of the emerging and prominent players of the market. Along with this, it provides comprehensive data analysis on the risk factors, challenges, and possible new market avenues.

The report has viewed the current top players and the forthcoming contenders. Business procedures of the vital participants and the new entering market ventures are concentrated in detail in this report. The report also encompasses SWOT investigation, income offer, and contact data. The report throws light on specific drivers, restraints, opportunities, challenges, and other determinants that tremendously favor and oppose normal growth in the globalLive Cell Imagingmarket. It also covers the product pricing factors, growth, emerging and dominant trends, overall market dynamics, and market size. The report includes a wide spectrum of the market to provide insightful data for the forecast period 2020-2025.

Global live cell imaging market is expected to reach USD 3,529.26 Million by 2025, at a CAGR of 8.97% from 2018 to 2025

NOTE:Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post the COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

DOWNLOAD FREE SAMPLE REPORT:https://www.fiormarkets.com/report-detail/386014/request-sample

The report gives the market segments that have been fragmented into sub-segments. The study gives a transparent view of the global market and includes a thorough competitive scenario and portfolio of the key players functioning in it. The report offers fundamental opinions regarding the market landscape, emerging and high-growth sections of the globalLive Cell Imagingmarket, high-growth regions, and market drivers, restraints, and also market chances. It targets estimating the current market size and growth potential of the global market across sections such as also applications and representatives.

Competitive Analysis:

Te report accurately profiles key vendors and players functioning in the globalLive Cell Imagingmarket, in terms of their ranking and core competencies, together with determining the competitive landscape. It also studies competitive developments such as partnerships and collaborations, mergers, and acquisitions (M&A), research and development (R&D) activities, product developments, and expansions in the global market.

The top key players profiled in this report are:Danaher Corporation, Carl Zeiss AG, Nikon Corporation, Olympus Corporation, PerkinElmer, Inc., GE Healthcare, Bruker Corporation, Thermo Fisher Scientific Inc., Sartorius AG, BioTek Instruments, Etaluma, Inc., CytoSMART Technologies, NanoEnTek Inc., Leica Microsystems, Dickinson and Company, Becton, Sigma-Aldrich Corporation, Molecular Devices, LLC

Other Segment Analysis:

Segment classification of the market structure has been encouraged by our research experts to allow readers to comprehend the versatility of the market in terms of product and service variation. The market has been examined with vital market-specific developments across segment categories. Market segments such as type and application are also determined by quantitative and qualitative review. Type market size bifurcated into its product typeInstruments, Consumables, Software, Servicesin terms of Volume (K Units) and Value (USD Million). Market segment by application, split into:Cell Biology, Stem Cells, Developmental Biology, Drug Discovery

Request forCustomization:https://www.fiormarkets.com/enquiry/request-customization/386014

Country-Wise Assessment:

The report presents an understanding of the regional, country, and even local developments. Overview of globalLive Cell Imaging market dynamics such as industry outlook, value chain developments, SWOT and PESTEL assessment as well as Porters Five Point analysis. The report also encompasses crucial analytical reviews on key elements, trends, current, and future perspectives. By regional analysis, the report covers:North America, Europe, Asia Pacific, South America, and the Middle East and Africa.

ACCESS FULL REPORT:https://www.fiormarkets.com/report/live-cell-imaging-market-by-product-instruments-consumables-386014.html

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team (sales@fiormarkets.com), who will ensure that you get a report that suits your needs.

Contact UsMark StonePhone:+1-201-465-4211Email:sales@fiormarkets.comWeb:www.fiormarkets.com

This content has been distributed via CDN Newswire press release distribution service. For press release enquires please mail us at contact@cdnnewswire.com.

Originally posted here:
Global Live Cell Imaging Market Size is Expected to reach USD 3529.26 Million by 2025 and Registeri - PharmiWeb.com

Trabecular bone organoid model for studying the regulation of localized bone remodeling – Science Advances

Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone remodeling by means of tightly localized regulation. The molecular and cellular processes that regulate localized bone remodeling are poorly understood because of a lack of relevant experimental models. A tissue-engineered model is described here that reproduces bone tissue complexity and bone remodeling processes with high fidelity and control. An osteoid-inspired biomaterialdemineralized bone paperdirects osteoblasts to deposit structural mineralized bone tissue and subsequently acquire the resting-state bone lining cell phenotype. These cells activate and shift their secretory profile to induce osteoclastogenesis in response to chemical stimulation. Quantitative spatial mapping of cellular activities in resting and activated bone surface coculture showed that the resting-state bone lining cell network actively directs localized bone remodeling by means of paracrine signaling and cell-to-cell contact. This model may facilitate further investigation of trabecular bone niche biology.

Read the original:
Trabecular bone organoid model for studying the regulation of localized bone remodeling - Science Advances

Aging Starts at 30 In Your Body. Here’s What to Do About it – The Beet

You know how every decade your body loses muscle mass, and adds more fat, in what is considered an inevitable downward spiral into aging? This process is called sarcopenia and "sad to say, it starts inyour 30s," according to Susan Vannucci, RD, Ph.D. Asyour body's lean muscle mass decreases, "we not only lose strength but our basal metabolic rate or the amount of energy or calories your body needs every day becomes reduced." And that means weight gain! This process accelerates with age, making it more and more difficult to even maintain, much less lose, weight.

Well, there is a way you can fight it. But first, you have to acknowledge that the changes that happen over time don't just pop up one day, but rather are insipient and gradual, and they have everything to do with the choices you make at the table and in your workout routine.Here's the good news: You can control all that.

Just as the beauty industry has taught young people to wear sunscreen at the beach when they don't have a wrinkle in sight, so does the nutritionist savvy authorities (not the food industry, but theprofessionals who you pay to give you smart nutrition advice), want you to think about eating the healthiest foods and doing resistance traininglike burpees, kettlebells, weights, and HIIT workouts) that put your muscles under stresson a regular basis.

The only debate is: What are the right foods to eat? And how can you harness the powers of antioxidants to spring your cells into action, to fight off inflammation, repair their own cellular infrastructure, andfunction optimally, as they do in a young person, for decades to come?

"Aging is not a disease. There are diseases of aging, but it doesn't mean they are inevitable," says Vannucci, RD, Ph.D. a wellness expert in New YorkCity who provides individual wellness counseling in-person and online for individuals age 45 and up nationwide. Su, as her patients call her, has a strong academic and medical background, having gotten her degree in cellular biology, as well as training in nutrition. She is currently working on a book, Age Strong, Live Long with her kick-ass trainer, Antoinette Vo, who has her doing 60-pound deadlifts at the age of 71.

"I ran my last marathon for my sixtieth birthday, and it was my fastest," Vannucci explains. She retired her running shoes to save her back, after a few issues, but her current workouts of strength training, Pilates and power walking, and what she calls "heavy lifting" have made her stronger than she was decades ago. "My attitude is that you can forestall aging, and by and large, unless you have a genetic condition, all of the diseases related to aging are not inevitable. Loss of muscle mass and body fat are not inevitable. You just have to work at it."

Because she started her career asa scientist her patients are likelier to listen to her. So when her patients askher the mechanisms of how something works and why, if she doesn't know the answer she will find it out.The questions we asked her today are simple: How can you eat and workout to reverse the clock, or at least slow the hands of time, to make sure when you hit your 60th or 70th birthday your body is as fit or fitter than it was at half that age?

Susan Vannucci: The thing about food is it definitely impacts aging.If you want to forestall the process of aging, you need to reduce systemic inflammation. Because it's reallythe same thing. Inflammation causes aging, on a cellular level. So first you have to get everything out of your body that causes inflammation. That is red processed meat, chemicals, added sugar, and anything that is processed.

Years ago, Time magazine did a big cover story on inflammation, calling it the Silent Killer. Inside the writer calls it"Inflam-aging." It is such a great term! You think about inflammation, such as when you cut yourself or bruise yourself, but that is a momentary stream of helpful fluid to repair a site. The concept we are talking about is not that temporary state of cell repair. It's more like a flood-state that suppresses all cellular functions. When you have systemic inflammation in your bodythatis chronic, thatis one of the biggest contributors to aging.

Susan Vannucci: I tell clients: The biggest problem is junk food and added sugar in the diet.The fact that people don't even know how big the basket of junk food is. They might think they are eating healthy but even if it is vegetarian or vegan, just because it is lacking animal product does not mean it's healthy! it may be so processed that it's junk food. Read the label. Most packages foods are so full of chemicals.

In the effort to lower inflammation, eat more plant-based foods.But eat them in their whole form. potato chips and corn chips are still plant-based.

Susan Vannucci: When my daughter was a teenager, said she wanted to go vegetarian. I worried that to her, that meant a diet high in potato chips. I made a deal with her. She was a competitive athlete, a sprinter, and hurdler, a competitive horsewoman and I made a deal with her: You heed a healthy diet, and I will totally support you. You have to be able to eatall the beans and legumes and plant-based proteins that are whole foods and recognize what makes a complete protein.

She and I were always going to write this book together on what to do when your child announces they want to go vegetarian or vegan. She stuck with it until she married a guy who likes meat, then she got pregnant and so now the way she eats is thatany meat in her diet is more of a condiment than the main part of the meal.

Susan Vannucci: The first thing is we talk about what they are already doing to get a sense of where they arein this journeybecause I always say I don't put people in diets. We don't talk about being "good" or "bad," and I don't weigh anybody. I provide the information they need and assume we are all responsible adults and if you want to do this, you can.

Susan Vannucci: Get rid of all the white stuff. Things that are processed. Most things that come in bags, boxes, or containers of any kind can sit on a truck or a shelf for a long time ... the chemicals in it are the problem. Get rid of that stuff. Flip to whole grains, whole foods, lots of water, and move more! That should not be so hard to do.

When people start to read the labels of boxes that hold the food they are about to eat, thinking they are healthy foods, like whole wheat crackers, they can be horrified. How many names do we have for sugar? Not uncommonly if you look on a label there will be three to five kinds of sugar in there.

Susan Vannucci:If someone isreally hungry (not bored or in need of a diversion) cut-up vegetables. carrots, celery with a little bit of hummus, or some edamame is a really good snack. A lot people come to me with the same complaint. When they worked all day in an office and get to the end of the day, and leave to go home,by the time they get home, they are starving. They walk in the front door and eat everything in sight. While waiting for dinner. Usually, that sets their cravings up. Now when we work from home it's constant snacking.

If you know you're a snacker keep healthy ones on hand: Rice cakes, hummus, and make avocado slices. Rice cakes can be healthy but not the caramel corn ones loaded with sugar. Just basically talking about whole grain rice cakes. They keep! And also keep nuts around.

Susan Vannucci: As for eating plant-based, of course, most people should eat more vegetables, fruits, nuts, seeds, and whole grains. But that doesn't mean that just because you're vegan or avoiding animal products that you're eating healthy. You have to avoid all processed foods. I am an advocate for healthy foods and what works best for people is not all the same.

For the planet, and because I absolutely hate, loathe, and detest the food industry, I would saychoosing a diet of mostlyplant-based eating is smart. But I know people like my husband who especially don't do as well on a solely plant-based diet.

Susan Vannucci:Normally, people are worried about protein but unless you are over 80 a lack of protein is unlikely to be your biggest problem. People who are older can sometimes be deficient because they don't eat enough calories in general. But if you're not in that category it's not something to worry about.

Susan Vannucci:For keeping muscle mass and not gaining fat you need to put your muscles into a state of stress. I enjoy heavy lifting. As you get older and by that, I mean anyone over 30, with the awareness that this aging process of losing muscle mass starts in your 30s, you have to do resistance training, and it has to be heavy.

For the most part, women are not going to bulk up. The way I started this was when I stopped marathon running I just felt I was losing my strength, so I got a trainer who got me into kettlebells, and it's been fabulous. I am stronger than ever at 71, and I am pretty strong. I have my cadre of kettlebells and I can deadlift 100 pounds.

The idea is not to lose muscle mass, so you need to add in resistance training several days a week. and go heavy. I can swing a kettlebell that is 40 pounds, and lift 60, but not over my head (that's dangerous). I will lift 18 pounds over my head.This is how women, especially can maintain muscle mass. The reason we lose it is that the equilibrium in our body between muscle synthesis and muscle breakdown starts to shift as we get older. So you breakdown more than you build back up. And slowly over time, you lose your muscle mass. That's what causes aches, pains, falls, and lack of balance. The stronger the body, the less you age.

Susan Vannucci: Vitamin D3 is absolutely important.Almost no one gets enough D3 naturally. And Omega-3 is important, either from algae or fish oil. We have come to learn that vitamin D is essential in so many pathways. Way beyond just bone health. It's vital in fighting cancer, MS, and more. And because of sunscreen, and working indoors, staying out of the sun, people are vitamin D deficient. Yes, cases of COVID-19 have been worse for those who are D deficient, so taking D is a good idea to strengthen your ability to fight viruses.

Why Omega 3 because what's happened is we need all the omegas, the Omega-3s the Omega-6s, and the Omega-9s. But because of the food industry, ourdiets lack Omega-3. They have taken out the Omega-3 from foods, and increase the Omega-6 to increase things like shelf life. So for most people, the ratio is way out of balance. And what happens is our cell membranes are made of fat. They have a lipid bilayer and they are constantly turned over, like most things in the body, so if you have too much Omega-6 in your body, that gets overrepresented in your cell membranes, and then when anything happens, like internal stress and those Omega-6s get broken down, and they are pro-inflammatory. So you need to supplement with Omega-3 to keep your cell membranes healthy and intact.

Susan Vannucci: So that is why people are living with this internal fire.Inflammation is a precursor of a lot of diseases, and this is inflammation is something you can't see because it's going on inside of you on a cellular level. You can see the effects, like high blood pressure or you can take a blood test and test for what's called C-reactive protein.

That can be tested for, andthat's probably the easiest and most common marker for people. C-reactive protein is a marker that indicates there is inflammation in the body, and if yours is elevated it can be a signthat there's inflammation in the arteries of the heart, and that you are at risk for heart attack or stroke.High blood pressure is another sure sign of inflammation. If there should be an impetus to go to a plant-based diet it's hypertension. I tell people that the DASH. diet works which are mostly made up of plant foods.

To connect with Susan Vannucci, visit her website, Wellnesswith Susan Vannucci, Ph.D.

1. How old are you?20 or less = 0; 21-30 = 1; 31-40 = 2; 41-50 = 3; 51-60 = 4, >60 = 5

2. Have you had a heart attack or stroke? Yes = 5; No = 0

3. Do you have high blood pressure (>140/90), or high cholesterol ( >220; HDL<35)? Yes = 5; No = 0

4. Do you currently smoke?Yes = 5, go to question 5; No = 0, skip to 6

5. Do you smoke more than 10 cigarettes a day?Yes = 5, go to question 7; No = 0, go to question 7

6. Have you ever smoked regularly?No, never = 0; quit more than 10 years ago = 1; 5-10 years ago = 2; quit within the past 5 years = 3

7. Do you have diabetes- either type 1 or type 2? Yes = 5; No = 0

8. Do you have periodontitis (severe gum disease)? Yes = 3; No = 0

9. Do you have medical complaints but doctors cant find anything wrong? Yes = 3; No = 0

10. Are you often fatigued, even after a good night sleep? Yes = 5; No = 0

11. Do you have trouble falling asleep and/or wake up too early and cant go back to

sleep?Yes = 3; No = 0

12. What is your Body Mass Index (BMI)? Weight (lbs) x 704.5 / height (in)2 < 25 = 0; 25 29.9 = 3; >30 = 5

13. Do you feel depressed or sad most of the time? Yes = 3; No = 0

14. On an average day, how much pain do you have?No pain = 0; minor aches, nothing serious = 1; annoying pain = 2; sometimes a lot of pain, depends on the day = 3; usually in pain = 4

15. How often do you eat fish/ take omega-3 supplements/week? None = 3; 1 or 2 = 0; >3 = -3

16. How many servings of fruits and vegetables do you eat/day? None = 5; 1-3 = 3; 3-7 = 0; >7 = -5

17. What is the population size of where you live?> 1 million = 5; 500,000 1 million = 3; < 500,000 = 0

18. What fuel do you use for home heating?Kerosene burner/wood stove = 5; oil or gas furnace = 3; heat pump or electric = 0

19. How often do you use heavy-duty cleaning products (bleach, ammonia, bath, and shower cleaners, mildew removers, etc) in your home?

Never, only use natural cleaners = 0; rarely = 1; often = 2; daily = 4 20. Do you regularly use air fresheners, either spray or plug in? Yes = 2; No = 0

21. How often do you feel stressed?

Rarely = 0; About average = 1; Often = 2; Always = 5

22. How often do you exercise?

Never = 5; rarely (1x week or less) = 4; 1-2/week = 1; regularly,

3 or more/week = -523. Do you regularly take steroids either by prescription or performance- enhancing?

Yes = 5, No = 024. Do you take aspirin, ibuprofen, or other NSAIDs, or statin medication?

Yes = -5; No = 025. Are you exposed to pesticides?

Frequently = 5; Sometimes = 3; Never = 0 Total Inflammation Score =

Max = 98, Lowest = 18Your Score: 50- 98: High inflammation risk. Dont panic!! This only means you have a higher than average risk of developing the disease- but there are things you can do! Talk to your doctor ask about testing your C-reactive protein (CRP). And follow guidelines to reduce your risk score.Your Score: 20-49: Moderate inflammation risk. Look for areas where you scored the highest and plan ways to change those risk factors, especially with increased age.Your Score: < 20: Congratulations!! This is a great place to start towards a lifetime of wellness and disease prevention. Pay attention to areas that will increase risk in the future!

See the rest here:
Aging Starts at 30 In Your Body. Here's What to Do About it - The Beet

Brain Cells That Help Drive Bodily Reaction to Fear, Anxiety Identified Neuroscience Breakthrough Could Lead to Mental Health Treatments -…

Pnoc neurons in the BNST shown in green. Credit: Hiroshi Nomura, PhD

A feat of basic neuroscience co-led by UNC School of Medicine scientists, the discovery of a set of arousal-related neurons could help scientists develop better treatments for anxiety disorders, psychiatric illnesses.

Strong emotions such as fear and anxiety tend to be accompanied and reinforced by measurable bodily changes including increased blood pressure, heart rate and respiration, and dilation of the eyes pupils. These so-called physiological arousal responses are often abnormally high or low in psychiatric illnesses such as anxiety disorders and depression. Now scientists at the UNC School of Medicine have identified a population of brain cells whose activity appears to drive such arousal responses.

The scientists, whose study is published in Cell Reports, found that artificially forcing the activity of these brain cells in mice produced an arousal response in the form of dilated pupils and faster heart rate, and worsened anxiety-like behaviors.

The finding helps illuminate the neural roots of emotions, and point to the possibility that the human-brain counterpart of the newly identified population of arousal-related neurons might be a target of future treatments for anxiety disorders and other illnesses involving abnormal arousal responses.

Focusing on arousal responses might offer a new way to intervene in psychiatric disorders, said first author Jose Rodrguez-Romaguera, PhD, assistant professor in the UNC Department of Psychiatry and member of the UNC Neuroscience Center, and co-director of the Carolina Stress Initiative at the UNC School of Medicine.

Rodrguez-Romaguera and co-first author Randall Ung, PhD, an MD-PhD student and adjunct assistant professor in the Department of Psychiatry, led this study when they were members of the UNC laboratory of Garret Stuber, PhD, who is now at the University of Washington.

This work not only identifies a new population of neurons implicated in arousal and anxiety, but also opens the door for future experiments to systematically examine how molecularly defined cell types contribute to complex emotional and physiological states, Stuber said. This will be critical going forward for developing new treatments for neuropsychiatric disorders.

Anxiety disorders, depression, and other disorders featuring abnormally high or low arousal responses affect a large fraction of the human population, including tens of millions of adults in the United States alone. Treatments may alleviate symptoms, but many have adverse side effects, and the root causes of these disorders generally remain obscure.

Untangling these roots amid the complexity of the brain has been an enormous challenge, one that laboratory technology has only recently begun to surmount.

Rodrguez-Romaguera, Ung, Stuber and colleagues examined a brain region within the amygdala called the BNST (bed nucleus of the stria terminalis), which has been linked in prior research to fear and anxiety-like behaviors in mice. Increasingly, scientists view this region as a promising target for future psychiatric drugs. In this case, the researchers zeroed in on a set of BNST neurons that express a neurotransmitter gene, Pnoc, known to be linked to pain sensitivity and more recently to motivation.

The team used a relatively new technique called two-photon microscopy to directly image BNST Pnoc neurons in the brains of mice while the mice were presented with noxious or appealing odors stimuli that reliably induce fear/anxiety and reward behaviors, respectively, along with the appropriate arousal responses. In this way, the scientists found that activity in these neurons tended to be accompanied by the rapid dilation of the pupils of the mice when the animals were presented with either of these odor stimuli.

The researchers then used another advanced technique called optogenetics using light to control genetically engineered cells to artificially drive the activity of the BNST Pnoc neurons. They found that spurring on BNST Pnoc activity triggered a pupillary response, as well as increased heart rate. Optogenetically driving the neurons while the mice underwent an anxiety-inducing maze test (traditionally used to assess anxiety drugs) increased the animals signs of anxiety, while optogenetically quieting the neurons had the opposite effect.

Essentially we found that activating these BNST Pnoc neurons drives arousal responses and worsens anxiety-like states, Rodrguez-Romaguera said.

The discovery is mainly a feat of basic neuroscience. But it also suggests that targeting arousal-driving neurons such as BNST Pnoc neurons with future drugs might be a good way to reduce abnormally strong responses to negative stimuli in anxiety disorders, for example, and to boost abnormally weak responses to positive stimuli in depression.

The study uncovered evidence that BNST Pnoc neurons are not all the same but differ in their responses to positive or negative stimuli, and the researchers are now cataloguing these BNST Pnoc neuron sub-groups.

Even this small part of the amygdala is a complex system with different types of neurons, Ung said. Teasing this apart will help us understand better how this system works.

Reference: Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli by Jose Rodriguez-Romaguera, Randall L. Ung, Hiroshi Nomura, James M. Otis, Marcus L. Basiri, Vijay M.K. Namboodiri, Xueqi Zhu, J. Elliott Robinson, Hanna E. van den Munkhof, Jenna A. McHenry, Louisa E.H. Eckman, Oksana Kosyk, Thomas C. Jhou, Thomas L. Kash, Michael R. Bruchas and Garret D. Stuber, 10 November 2020, Cell Reports.DOI: 10.1016/j.celrep.2020.108362

The other co-authors of the study were Hiroshi Nomura, James Otis, Marcus Basiri, Vijay Namboodiri, Xueqi Zhu, Elliott Robinson, Hanna van den Munkhof, Jenna McHenry, Louisa Eckman, Oksana Kosyk, Thomas Jhou, Thomas Kash, and Michael Bruchas.

The research was supported by the National Institute of Mental Health (F32-MH113327, F30-MH115693, K99-MH118422, T32-MH093315, K99-MH115165, R01-MH112355), the National Institute of Neurological Disorders and Stroke (T32-NS007431), the National Heart, Lung, and Blood Institute (R01-HL150836), the National Institute on Drug Abuse (F32-DA041184, R37-DA032750 & R01-DA038168), the Childrens Tumor Foundation, the Brain and Behavior Research Foundation, and the Yang Biomedical Scholars Award.

View post:
Brain Cells That Help Drive Bodily Reaction to Fear, Anxiety Identified Neuroscience Breakthrough Could Lead to Mental Health Treatments -...

Nevada ENDURE seeks to improve diversity in neuroscience – Nevada Today

Neuroscience has a representation problem. Fewer students from underrepresented backgrounds pursue higher education in the field which leads to a less diverse group of neuroscience researchers, teachers and professionals. The Nevada ENDURE (Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences) program, launched in January by Professors Mariann Weierich, Marian Berryhill and Dennis Mathew hopes to help break this cycle. The program provides undergraduate students from diverse backgrounds including ethnic and racial minorities, first-generation college students, students with disabilities, and economically disadvantaged students who plan to pursue doctoral training in neuroscience with intensive research training experience. The program facilitates intellectual development and removes some of the barriers to the pursuit of graduate training.

"We [are offering] students in northern Nevada the opportunity for outstanding research training in neuroscience. We anticipate increasing the competitiveness of UNR graduates from underrepresented backgrounds for doctoral training in neuroscience."

ENDURE programs are funded nationwide by the National Institute on Neurological Disorders and Stroke (NINDS). Professor Weierich joined the College of Science as the James K. and Lois Merritt Mikawa Distinguished Professor of Psychology in 2019 after leading an ENDURE program at the City University of New York Hunter College. Soon after arriving at the University of Nevada, Reno, she began the work to launch an ENDURE program here as well.

The University of Nevada, Reno represents an extension of the NIH/NINDS ENDURE network, through which we can offer to students in northern Nevada the opportunity for outstanding research training in neuroscience, Weierich said. We anticipate increasing the competitiveness of UNR graduates from underrepresented backgrounds for doctoral training in neuroscience. The program is brand new and were recruiting now! We plan to recruit from current TMCC and UNR neuroscience-related majors, including neuroscience, biology, and psychology (or TMCC equivalent). However, any eligible student with a plan to pursue doctoral training in neuroscience is welcome to apply. Both UNR and TMCC have a wealth of talented undergraduates from NIH-defined underrepresented backgrounds, and well ask the help of our academic communities to share information about this program.

The Nevada ENDURE Program complements Weierichs named position, the James K. and Lois Merritt Mikawa Distinguished Professor of Psychology, with a similar mission.

The Nevada ENDURE mission and the Mikawa mission overlap a bit and also complement each other, Weierich said. The Mikawa mission is to enhance ethnic and racial diversity in clinical psychology, including clinical neuroscience, and that mission encompasses training at the undergraduate and doctoral levels. Building diverse scholarly communities across research fields is key to students feeling supported and welcome, so interaction between initiatives is ideal.

Nevada ENDURE trainees begin the program in the summer before the junior year, during which they are paid to spend 40 hours per week for ten weeks ($13/hr) working in a neuroscience research lab at one of the programs summer partner institutions: UC Berkeley, UC Davis, the University of Michigan, or Stanford. During the summer before the senior year, trainees similarly conduct research at a second summer partner institution. During the junior and senior academic years, trainees are paid to work 15 hours per week ($13/hr) in a University of Nevada, Reno neuroscience research lab. They also attend a weekly seminar that provides additional training in topics including professional development, research ethics, and preparing research for presentation. Finally, trainees attend and present at research conferences including the annual Society for Neuroscience meeting. All conference expenses are paid, as are University of Nevada, Reno registration fees that remain after financial aid.

The Nevada ENDURE program provides the invitation to get engaged, smart, curious students into neuroscience labs and on the road to a career in neuroscience-related fields, Berryhill said. We know about teaching, nursing, plumbing, etc. from early on, but many careers are less familiar to us say being a neuroscientist. College is a time to learn about unfamiliar careers and to build career awareness into undergraduate training. This program gives people money and time to learn about neuroscience, which is a growth area for careers. Neuroscience has a representation problem. We need more people from underrepresented backgrounds at the table.

Along with the three program directors, Weierich, Berryhill and Mathew, there are thirteen faculty mentors with varied research interests ready to accept Nevada ENDURE students into their labs. Students will have the opportunity to explore the many niche research areas within the broader field of neuroscience. Between the directors alone, three areas of specialization are represented.

The Nevada ENDURE program is actively seeking student applicants for summer 2021. The application deadline is February 10, 2021.

I am looking forward to working together with Drs. Weierich and Berryhill, Mathew said. The three of us represent different areas of neuroscience. Dr. Weierich is an expert in clinical psychology, Dr. Berryhill comes from a cognitive neuroscience background, and I am a cellular and molecular neurobiologist. Together, we form an excellent team and will each be heavily involved in this programs success.

The Nevada ENDURE program is actively seeking applicants for the inaugural group who will spend summer 2021 engaged in neuroscience research training. Students in their sophomore year are encouraged to apply. Students interested should visit the Nevada ENDURE website and review the eligibility and application requirements. The application deadline is February 10, 2021.

More here:
Nevada ENDURE seeks to improve diversity in neuroscience - Nevada Today

BMP5/7 protein offers promising therapeutics that could halt the progression of Parkinson’s disease – News-Medical.Net

Ben-Gurion University of the Negev researchers have discovered that the protein BMP5/7 offers promising therapeutics that could slow down or halt the progression of Parkinson's disease.

The findings were published in the prestigious clinical neurology journal, Brain.

Parkinson's disease, which affects over one million people in U.S. and 10 million worldwide, causes tremors and severe movement impairment due to progressive degeneration of dopamine-producing brain cells. It is believed that the protein "alpha-synuclein," present in all human brains, misfolds and forms toxic clumps in these cells, which causes the disease.

While current Parkinson's disease therapies improve symptoms, they are not effective in advanced illness stages and, unfortunately, do not slow or cure the disease.

Dr. Claude Brodski, M.D., head of the BGU's Laboratory for Molecular Neuroscience, discovered that BMP5/7 signaling in neurons was significantly reduced in dopamine-producing brain cells, which could contribute to Parkinson's disease advancement.

Indeed, we found that BMP5/7 treatment can, in a Parkinson's disease mouse model, efficiently prevent movement impairments caused by the accumulation of alpha-synuclein and reverse the loss of dopamine-producing brain cells. These findings are very promising, since they suggest that BMP5/7 could slow or stop Parkinson's disease progression. Currently, we are focusing all our efforts on bringing our discovery closer to clinical application."

Dr Claude Brodski, M.D, Head of Laboratory for Molecular Neuroscience, Ben-Gurion University of the Negev

BGN Technologies, Ben-Gurion University's technology transfer company, has filed several patent applications covering this breakthrough discovery.

Dr. Galit Mazooz Perlmuter, senior vice president of business development, bio-pharma at BGN Technologies, notes, "There is a vast need for new therapies to treat Parkinson's disease, especially in advanced stages of the disease. Dr. Brodski's findings, although still in their early stages, offer a disease-modified drug target that will address this devastating condition. We are now seeking an industry partner for further development of this patent pending invention."

Source:

Journal reference:

Vitic, Z., et al. (2020) BMP5/7 protect dopaminergic neurons in an -synuclein mouse model of Parkinsons disease. Brain. doi.org/10.1093/brain/awaa368.

See the rest here:
BMP5/7 protein offers promising therapeutics that could halt the progression of Parkinson's disease - News-Medical.Net

Neuroscientists Find Thin Line Between Love and Hate in the Mouse Brain – SciTechDaily

Mounting behavior, that awkward thrusting motion dogs sometimes do against your leg, is usually associated with sexual arousal in animals, but this is not always the case. New research by Caltech neuroscientists that explores the motivations behind mounting behavior in mice finds that sometimes there is a thin line between love and hate (or anger) in the mouse brain.

The research, which appears in the journal Nature, was conducted in the lab of David Anderson, the Seymour Benzer Professor of Biology, Tianqiao and Chrissy Chen Institute for Neuroscience Leadership Chair, investigator with the Howard Hughes Medical Institute, and director of the Tianqiao and Chrissy Chen Institute for Neuroscience.

Our lab is interested in understanding how social behaviors and underlying emotional states are controlled by the brain, explains lead author Tomomi Karigo, a postdoctoral scholar at Caltech. While we were studying social behaviors in mice, we sometimes noticed that male mice would mount other males, in a way similar to how they would mount females, Karigo says.

It was unclear whether these male mice tried to mate with a male because they simply mistook it for a female or if they knew it was a male but intended to establish dominance over it. The researchers hoped to understand whether a male mouse mounting another male mouse reflects a different intent than a mouse mounting a female mouse, and how mounting behavior is regulated in the brain.

To find out, the researchers first recorded videos of males mounting both male and female mice. Using machine learning, a type of software that learns and adapts through experience, they analyzed the videos to see whether there was anything different in the mounting behavior that was exhibited toward a male versus that toward a female mouse. The machine-learning analysis revealed no obvious difference in the mechanics of the mounting behavior.

The researchers then looked for other clues in the mounting males behavior that might differentiate female-focused versus male-focused mounting.

One clue was that male mice appear to sing to females while mating with them. These songs, known as ultrasonic vocalizations, are too high-pitched for humans to hear, but can be picked up with a special microphone. Karigo and the team found that mounting mice sing only to female mice, not to males. In addition, when a male is mounting another male, the two animals usually end up fighting after a short period of mounting. This does not happen in the case of a female mounting partner.

These results suggested that mounting behavior toward a female has a different meaning than mounting behavior toward a male. Specifically, mounting toward a male is probably the expression of dominance or mild anger (aggressive mounting) and not a reproductive (or so-called affiliative) behavior.

Next, the researchers explored which brain regions are responsible for each type of mounting behavior.

When a male mouse mounted male or female mice, the researchers observed neural activity in an area of its brain called the hypothalamus, which controls, among other things, hunger, thirst, metabolism, and defensive behaviors. In particular, two regions of the hypothalamus seemed to be involved: the medial preoptic area (MPOA) and the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). The MPOA showed high levels of activity when the male mouse was mounting, and singing to, a female; conversely, the VMHvl showed high levels of activity when the male mouse was mounting, but not singing to, a male.

The team then took a closer look at the activity of individual neurons in the MPOA and VMHvl. They found that distinct groups of neurons were activated during reproductive mounting and aggressive mounting, in each brain region. In addition, the researchers discovered that they could train a computer to correctly predict whether the mounting was sexual or aggressive, based purely on the pattern of neuronal activity in these two regions.

The researchers then tested to see if those brain regions actually controlled the two mounting behaviors, or if activity in the regions was simply correlated with the behaviors. They did this using a technique called optogenetic stimulation, in which light is used to trigger the firing of neurons. By directing the light to specific areas of the brain, researchers can induce neuronal activity there, and thus induce behaviors.

When the researchers presented a female mouse to a male mouse, the male mouse began to sing and mate with a female. But when the researchers stimulated the males VMHvl, the male stopped singing and started to show aggressive mounting behavior toward the female. Conversely, if a male mouse was engaging in aggressive behaviors toward another male and the researchers stimulated its MPOA, the aggressive mouse would stop fighting, begin to sing, and attempt to mate with the other male.

Karigo and Anderson liken this to a seesaw of love and hate. Activity in the MPOA tilts the seesaw toward love, while activity in the VMHvl tilts it toward hate (or aggression).

In this study, we used mounting behavior as an entry point to understand the underlying neural mechanisms that control emotional or motivational states, Karigo says. She says their findings advance our understanding of how the mouse brain, and more broadly the mammalian brain, works to control emotions, and she adds that they may one day help us to better understand human behaviors.

The paper describing their findings, titled, Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice, was published online by Nature on December 2, 2020. Co-authors are Ann Kennedy, formerly of Caltech and now at the Feinberg School of Medicine at Northwestern University; neurobiology graduate students Bin Yang and Mengyu Liu of Caltech; Derek Tai, formerly a research assistant at Caltech and now at the Touro University Nevada College of Osteopathic Medicine; Iman A. Wahle (BS 20), a Schmidt Scholar at Caltech; and David J. Anderson.

Reference: Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice by Tomomi Karigo, Ann Kennedy, Bin Yang, Mengyu Liu, Derek Tai, Iman A. Wahle and David J. Anderson, 2 December 2020, Nature.DOI: 10.1038/s41586-020-2995-0CaltechAUTHORS: 20200909-142458487

Funding for the research was provided by the National Institutes of Health, the Simons Collaboration on the Global Brain Foundation, the Howard Hughes Medical Institute and the Tianqiao and Chrissy Chen Institute for Neuroscience, of which Anderson is the director.

Read the original here:
Neuroscientists Find Thin Line Between Love and Hate in the Mouse Brain - SciTechDaily