ABC Shakes Up Thursday Lineup: 'Million Little Things' Out, 'Rebel' In Plus, 'Grey's Anatomy' Return Delayed Report Door
Physiology: What it takes to run a two-hour marathon – AW – Athletics Weekly
Study highlights the physiological demands linked to breaking the fabled barrier
Elite marathon runners need a specific blend of physiological traits to stand a chance of breaking two hours in the marathon, according to a study from the University of Exeter published in the Journal of Applied Physiology.
Eliud Kipchoge was one of the athletes tested by Andy Jones, professor of applied physiology at Exeter and the study author, along with 16 others who took part in the selection stage of the ambitious Nike Breaking2 project of 2017. Kipchoge was to record 1:59:40.2 in the INEOS 1:59 challenge after the trial had finished.
READ MORE: Eliud Kipchoge runs sub-two-hour marathon
Jones reported that a perfect balance of a high VO2 max (maximal oxygen uptake) and high lactate turn point (the percentage of someones VO2 max that can be sustained before anaerobic respiration, and fatigue, set in) were also necessary attributes of potential sub-two-hour runners.
His findings showed that a 59kg runner would need to take in about four litres of oxygen per minute (or 67ml per kg of weight per minute) to maintain two-hour marathon pace (21.1km/hr) meaning they take in oxygen during a marathon at double the speed a normal person of the same age would while sprinting flat out.
Some of the results particularly the VO2 max were not actually as high as we expected, Jones says. But these runners possess a perfect balance of characteristics for marathon performance.
Supreme efficiency of movement or an effective running action were also a requirement, to enable the body to use oxygen efficiently.
Of the athletes studied, 15 were from East Africa and, says Jones, seemed to know intuitively how to run just below their critical speed, close to the lactate turn point but never exceeding it.
Across the board, they displayed remarkable fatigue resistance.
Jones says: The requirements of a two-hour marathon have been extensively debated, but the actual physiological demands have never been reported before now.
This article was first published in the November 2020 edition of AW magazine, which is available to order online in print hereandread digitally here
See AW magazine each month for the latest performance news
For more on the latest athletics news, athletics events coverage and athletics updates, check out theAW homepageand our social media channels onTwitter,FacebookandInstagram
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Physiology: What it takes to run a two-hour marathon - AW - Athletics Weekly
Senior Lecturer in Physiology job with ULSTER UNIVERSITY | 242508 – Times Higher Education (THE)
Faculty of Life and Health SciencesSchool of MedicineSenior Lecturer in Physiology Salary 52,590 - 60,939 pa Closing date: 31 January 202Campus: Magee Ref 003402
As Northern Irelands civic University, Ulster is grounded in the heart of the community and strives to make a lasting contribution to society. Renowned for its world-class teaching, Ulster aims to transform lives, stretch minds and develop the skills required by a growing economy.
This is an exciting time for the University as we develop our new School of Medicine: our aim is to deliver Graduate Entry Medical Education as a means of widening access to medicine in Northern Ireland, seeking to produce doctors who are locally focussed, globally ambitious change agents who will work in and lead teams to improve the health of their patients and the wider community.
The creation of the new School offers a unique opportunity for the successful candidate to join a team of like-minded medical educators. The post is a key early appointment to the School allowing the successful applicant to play a pivotal part in shaping our educational delivery. We are seeking capable team players who are willing to explore new ways of delivery and who are enthused by the prospect of being involved in establishing a new School.
The successful candidate will work closely with the Foundation Dean and Director of Education to design, develop and deliver an imaginative and integrated approach to the learning of Physiology for medical students.
The focus of the School is educational excellence and, as such, will require partnership working with colleagues throughout the University and with a wide range of clinical stakeholders. The University has a global research profile to complement its strong educational achievements and maintenance of research activity is also supported and encouraged.
We prefer to issue and receive applications via our on-line recruitment website by clicking Apply.
Hard copy applications can be obtained by telephoning 028 7012 4072
The University is an equal opportunities employer and welcomes applicants from all sections of the community, particularly from those with disabilities.Appointment will be made on merit.
Ulster University holds a Bronze Athena SWAN award in recognition of our commitment to advancing gender equality in higher education. Read more on our website https://www.ulster.ac.uk/peopleandculture/employee-benefits/equality-diversity/athena-swan. The University has a range of initiatives to support a family friendly working environment, including flexible working.
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Senior Lecturer in Physiology job with ULSTER UNIVERSITY | 242508 - Times Higher Education (THE)
Conservation physiology and the COVID-19 pandemic – DocWire News
This article was originally published here
Conserv Physiol. 2021 Jan 12;9(1):coaa139. doi: 10.1093/conphys/coaa139. eCollection 2021.
ABSTRACT
The COVID-19 pandemic and associated public health measures have had unanticipated effects on ecosystems and biodiversity. Conservation physiology and its mechanistic underpinnings are well positioned to generate robust data to inform the extent to which the Anthropause has benefited biodiversity through alterations in disturbance-, pollution- and climate change-related emissions. The conservation physiology toolbox includes sensitive biomarkers and tools that can be used both retroactively (e.g. to reconstruct stress in wildlife before, during and after lockdown measures) and proactively (e.g. future viral waves) to understand the physiological consequences of the pandemic. The pandemic has also created new risks to ecosystems and biodiversity through extensive use of various antimicrobial products (e.g. hand cleansers, sprays) and plastic medical waste. Conservation physiology can be used to identify regulatory thresholds for those products. Moreover, given that COVID-19 is zoonotic, there is also opportunity for conservation physiologists to work closely with experts in conservation medicine and human health on strategies that will reduce the likelihood of future pandemics (e.g. what conditions enable disease development and pathogen transfer) while embracing the One Health concept. The conservation physiology community has also been impacted directly by COVID-19 with interruptions in research, training and networking (e.g. conferences). Because this is a nascent discipline, it will be particularly important to support early career researchers and ensure that there are recruitment pathways for the next generation of conservation physiologists while creating a diverse and inclusive community. We remain hopeful for the future and in particular the ability of the conservation physiology community to deliver relevant, solutions-oriented science to guide decision makers particularly during the important post-COVID transition and economic recovery.
PMID:33469469 | PMC:PMC7805516 | DOI:10.1093/conphys/coaa139
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Conservation physiology and the COVID-19 pandemic - DocWire News
Application of Nanotechnology in the COVID-19 Pandemic | IJN – Dove Medical Press
Dongki Yang
Department of Physiology, College of Medicine, Gachon University, Incheon, 21999, South Korea
Correspondence: Dongki YangDepartment of Physiology, College of Medicine, Gachon University, Incheon 21999, South KoreaTel +82-32-899-6072Fax +82-32-899-6588Email dkyang@gachon.ac.kr
Abstract: COVID-19, caused by SARS-CoV-2 infection, has been prevalent worldwide for almost a year. In early 2000, there was an outbreak of SARS-CoV, and in early 2010, a similar dissemination of infection by MERS-CoV occurred. However, no clear explanation for the spread of SARS-CoV-2 and a massive increase in the number of infections has yet been proposed. The best solution to overcome this pandemic is the development of suitable and effective vaccines and therapeutics. Fortunately, for SARS-CoV-2, the genome sequence and protein structure have been published in a short period, making research and development for prevention and treatment relatively easy. In addition, intranasal drug delivery has proven to be an effective method of administration for treating viral lung diseases. In recent years, nanotechnology-based drug delivery systems have been applied to intranasal drug delivery to overcome various limitations that occur during mucosal administration, and advances have been made to the stage where effective drug delivery is possible. This review describes the accumulated knowledge of the previous SARS-CoV and MERS-CoV infections and aims to help understand the newly emerged SARS-CoV-2 infection. Furthermore, it elucidates the achievements in developing COVID-19 vaccines and therapeutics to date through existing approaches. Finally, the applicable nanotechnology approach is described in detail, and vaccines and therapeutic drugs developed based on nanomedicine, which are currently undergoing clinical trials, have presented the potential to become innovative alternatives for overcoming COVID-19.
Keywords: COVID-19, SARS-CoV-2, antiviral drug, vaccines, nanoparticles, nanotechnology
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
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Application of Nanotechnology in the COVID-19 Pandemic | IJN - Dove Medical Press
This Easy 7-Minute Workout Will Help You Burn Fat, Says Science | Eat This Not That – Eat This, Not That
In 2013, Chris Jordan, MS, CSCS, NSCA-CPT, ACSM EP-C/APT, an elite exercise physiologist with experience training armed forces who is currently the director of exercise physiology at the Johnson & Johnson Human Performance Institute, created a simple bodyweight exercise routine that instantly took the fitness world by storm. It was called the "7-Minute Workout," and the instructional app containing variations of the routinecomplete with videos of Jordan himself offering stern instruction and demonstrationswiftly became one of the most-downloaded fitness apps on the market.
The 7-Minute workout preached the benefits of a type of training that was quickly gaining in popularity at the time: high-intensity interval training, or doing short bursts of really intense exercise split up by short periods of rest. Though the mechanics of HIIT were actually nothing newelite athletes have been doing several versions of it since the 1930sthe routine promised something truly incredible to busy, working Americans everywhere: Yes, you can get fitter fasterin less than 10 minutes!and you can do so in any basement or hotel room, using only the weight of your body, a wall, and perhaps a chair. Jordan published the compelling findings of his research on the benefits of the 7-Minute Workout in the American College of Sports Medicine's Health & Fitness Journal, and a phenomenon was born.
For anyone who has tried the 7-Minute Workout and may have found it too difficult to complete, Jordan just released a newer and "gentler" variation of it: The Standing 7-Minute Workout. The idea behind this new version, as Jordan explained to The New York Times, is to make the 7-Minute Workout more accessible to as many people as possible, including "my triathlete elder brother and my 82-year-old mother."
RELATED: 15 Underrated Weight Loss Tips That Actually Work
In this version, as the name suggests, he eliminates all of the exercises that may cause strain on the person's body by having them drop to the floor, including more difficult moves such as planks, pushups, and crunches. "Like the original workout, the standing workout includes exercises for cardio fitness, the lower body, the upper body, and core musclesin that order," explains the Times. "Each exercise lasts just 30 seconds with just five seconds of rest in between. To get the most out of the workout, do each exercise at relatively high intensityabout a 7 or 8 on a scale of 1 to 10."
You can view a video of Jordan explaining and demonstrating the workout here.
If you have doubts that you can burn fat by exercising in such a short amount of time, Jordan has plenty of science to back him up. "When it comes to the immediate health benefits of this sort of high-intensity exercise, it's all about blood sugar," Timothy Church, Ph.D., a professor of preventive medicine at Louisiana State University, explained to Men's Journal. If you're jumping rope or running sprints, for example, your body instantly gets to processing your blood sugar, which aids in weight loss, and the stress on your muscles leads to greater conditioning. The benefits simply compound from there.
"As with other forms of exercise, when your muscles grow, they pull on your skeletal system, increasing your bone density," explains Men's Journal. "A lot of new research also shows that interval training triggers the release of macrophages and killer T cells, boosting the body's immune function for hours after your last pushup or pullup."
As your fitness grows, know that you can perform these exercises for longer periods of time than 7 minutesbut we're not talking about hours. Ten, 15, or 20 minutes is plenty of exercise, as LSU's Church told Men's Journal. After all, think of all of the weight lifters who do their sets, and then simply walk around the gym staring at the clock, their heads bobbing to music. "Most people are really doing hard work for only 15 to 20 minutes anyway," he said.
For more great weight loss advice, make sure you're aware of The One Workout That Drives 29 Percent More Fat Loss, According to Science.
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This Easy 7-Minute Workout Will Help You Burn Fat, Says Science | Eat This Not That - Eat This, Not That
Methods of quantitative modeling revolutionize drug development – McGill Tribune
Mathematics and computer science are revolutionizing the way new drugs and treatments are tested and implemented. A new paper published in Chaosand written by U4 McGill Physiology and Math major Sofia Alfonso, postdoctoral researcher Adrianne L. Jenner, and Dr. Morgan Craig from the University of Montreals department of Math and Statistics, explores new alternatives to the challenges of using quantitative tools.
In the pharmaceutical industry, pre-clinical and clinical trials are challenging, time-consuming, and costly. Virtual drug trials allow researchers to better understand and treat complex diseases such as cancer, diabetes and depression. Conducted faster than conventional clinical trials, virtual drug trials also allow more efficient and affordable distribution of treatments to the public due to high recruitment rates, better compliance, and lower drop-out rates. The paper presents multiple case studies that test experimental medications using mathematical modelling.
Such studies are considered in silico, as they are conducted by a computer program and do not involve live patients, as an in vivotrial would. These simulations can predict the effect of a medication on virtual patients, leading to important insights about a drugs efficacy before investing time and money into human subject testing.
Alfonso and Craig say that the pharmaceutical industry is already using in silicomodels for research and emphasize the need for collaboration between experimentalists and clinicians in order to develop more accurate and effective models.
In drug development, for example, study of a novel drug delivery device for anti-HIV therapy contributed to its continued development and ongoing clinical trials of similar devices, Craig wrote in an email to The McGill Tribune.
One case study explored the potential of mathematical modeling in the development of treatments for infectious diseases, such as the Herpes Simplex virus (HSV) or the Human Immunodeficiency Virus (HIV). Based on data of viral shedding collected from real patients, an experimental drug was administered to a virtual patient infected with HSV. Researchers then optimized the drugs dose for clinical trials, paving the way for future studies of similar drugs for the antiviral treatment of HIV and HSV.
A big challenge is finding adequate parameters in the literature such that the model can be accurately calibrated, Alfonso wrote in an email to the Tribune, referring to the need for data from clinicians to construct accurate models. Thus, collaborative efforts that bridge quantitative approaches with experimental work can be integral to developing useful models.
The researchers are optimistic about the potential of virtual trials in the development of treatments more quickly and less invasively during public health crises such as COVID-19. Transitioning to remote trials could limit the risks of in-person contact, especially in medical settings.
Currently, we have been working with an interdisciplinary team on modelling COVID-19 in virtual patients, allowing us to simulate the mechanisms resulting in severe SARS-CoV-2 infection, Alfonso wrote. I am hopeful that as we gain more data, our model will provide further clinically relevant findings.
Given the importance of quantitative methods in physiology, Alfonso emphasizes the opportunities for future physiology students willing to delve into mathematics, physics, and computer science.
Craig also calls upon physiology students to maintain an open mind on these disciplines, noting that quantitative methods are already being implemented by the industry.
Many researchers have summer positions for undergraduates that provide hands-on training, Craig wrote. In fact, Sofia [Alfonso] started in my lab as a PHGY 461 student and has continued as a research assistant since.
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Methods of quantitative modeling revolutionize drug development - McGill Tribune
Study: Temperature Scanners of Limited Value in Detecting COVID-19 – Pharmacy Times
A new study published in Experimental Physiology suggests that taking temperature readings of a persons fingertip and eye would give a significantly better and more reliable reading and help identify those with fever compared to a full body scan.
"If scanners are not giving an accurate reading, we run the risk of falsely excluding people from places they may want, or need, to go, and we also risk allowing people with the virus to spread the undetected infection they have," said professor Mike Tipton, University of Portsmouth, in a press release.
The study discovered 4 key factors, including:
The researchers found that a significant proportion of those with COVID-19 do not have a fever, and fewer than half of those admitted to the hospital with suspected COVID-19 had a fever. Although the majority of positive cases go on to develop a high temperature after being admitted to the hospital, they were infectious before their temperature soared, according to the study authors.
"We think we can improve the identification of the presence of fever using the same kit but looking at the difference between eye and finger temperatureit's not perfect, but it is potentially better and more reliable, Tipton said in a press release.
A change in deep body temperature is a critical factor in diagnosing disease with as little as a 1-degree increase indicating a potential disease. The many methods of detecting deep body temperature are either expensive, invasive, or time-consuming to be widely used outside of the hospital setting, according to the study authors.
A previous study in 2005 that compared forehead temperatures with 3 different infrared thermometers gave different temperatures for 1000 people, ranging from 31 C to 35.6 C. The infrared thermometer measurements alone varied by as much as 2 C. Another study found that more than 80% of 500 people tested using infrared gave a false negative result.
Such differences in skin temperature could be due to multiple reasons, including whether the individual has recently exercised, has an infection, sunburn, how close an individual stands to a scanner, and even blood pressure, according to the study.
REFERENCETemperature scanners of limited value in detecting COVID-19. EurekAlert! https://www.eurekalert.org/pub_releases/2021-01/tps-tso011421.php. Published January 14, 2021. January 15, 2021.
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Study: Temperature Scanners of Limited Value in Detecting COVID-19 - Pharmacy Times
Marcus Neuroscience Institute’s Advanced Neuro-interventional Suite Provides State-of-the-Art Technology – Baptist Health South Florida
Marcus Neuroscience Institutes new advanced neuro-interventional suite has the first-in-the-nation distinction of featuring two state-of-the-art technologies at one location: Boca Raton Regional Hospital, part of Baptist Health South Florida.
The hospital is the first in the nation to feature both the highly sophisticated Siemens ARTIS Icono Biplane imaging equipment and Corindus CorPath GRX Robotic surgical system in one place.
For patients, the Institutes neuro-interventional suite provides the most advanced, minimally invasive treatments. They will benefit from speedier, more precise care when facing vascular and neurological conditions such as stroke and brain aneurysms.
(Watch video now: Hear from Brian Snelling, M.D., medical director of the Institutes Marilyn & Stanley Barry Center for Cerebrovascular Disease & Stroke, as he describes the state-of-the-art technologies at Marcus Neuroscience Institute. Video by Dylan Kyle.)
The new suite is part of an ongoing expansion of Marcus Neuroscience Institute.
Having both the Corindus CorPath GRX Robot, as well as the Siemens ARTIS Icono Biplane, quite simply allows us to deliver an unparalleled amount of technology to the treatment of stroke patients, explains vascular neurosurgeon Brian Snelling, M.D., medical director of the Institutes Marilyn & Stanley Barry Center for Cerebrovascular Disease & Stroke. This results in more precise maneuvers with devices within the blood vessels of the brain, faster times to treatment shorter recovery times and better outcomes for the patients in our community.
The Siemens ARTIS Icono Biplane is a sophisticated imaging system that offers physicians views of the brain on two different planes, which can be adjusted as needed. The system has a very wide range of potential positions and can switch effortlessly between 2D and 3D imaging. It offers faster, more precise cone beam CT images, even in challenging areas like the skull base.
In stroke diagnosis, the systems more advanced imaging saves time, helps physicians visualize collateral vessels and supports sounder treatment decisions before performing life-saving procedures. The system is also a key tool for brain aneurysm treatment and other conditions that require intricate device placement and excellent image quality.
We treat patients with all types of stroke, said Dr. Snelling. Stroke is a umbrella term that can mean many things. It could mean bleeds in the brain; it can also mean blockages of the brain. So, we treat things from blockages of brain arteries to brain aneurysms to arterial venous malformations of the brain in the suite. With a machine like this, we can deliver the highest quality care as quickly as possible, providing the best possible outcomes to our patients in our community.
The Corindus CorPath GRX Robotic System, meanwhile, allows physicians to perform incredibly complex vascular procedures, enabling millimeter by millimeter movement through a patients arteries in minimally invasive procedures. Seated in a radiation-protected cockpit, physicians use joystick controls to robotically advance catheters, balloons and stents to clear blockages and restore blood flow.
We are incredibly proud to be the only hospital in the nation to have both of these advanced systems in one suite, said Lincoln Mendez, Boca Raton Regional Hospitals CEO. Our goal in all areas is always the highest level of precision medicine to benefit patients and save lives.
The advanced neuro-interventional suite was made possible by the generosity of Bernie and Billi Marcus and The Marcus Foundation. It is a component of the ongoing expansion at the Institute. Our level of gratitude simply cannot be measured we deeply value the steadfast support and belief that Mr. and Mrs. Marcus have in our future, said Frank D. Vrionis, M.D., director of Marcus Neuroscience Institute.
Saving and changing the lives of individuals with neurological disease or impairment has always been an important philanthropic focus for us, explains Bernie Marcus. We want the Marcus Neuroscience Institute to stay at the forefront of patient care and this new technology allows us to offer unparalleled clinical services in South Florida.
Tags: Boca Raton Regional Hospital, Marcus Neuroscience Institute
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How Will Global Neuroscience Market React from 2021 Onwards? KSU | The Sentinel Newspaper – KSU | The Sentinel Newspaper
The report by Zion Market Research titled How Will Global Neuroscience Market React from 2021 Onwards?Research Reportpresents a profound comprehension regarding the functioning and expansion of theNeuroscience Marketon a regional and global level. This analysis report is the collation of all the wide-ranging information relating to the market statistics during the recent years as well as forecasts for coming years. To begin with, the report comprises the major players actively participating and competing within the Neuroscience Market; it entails several companies, manufacturers, suppliers, organizations, and so on. Thus, the report will assist in understanding the initiatives and approaches implemented by these players to create and reinforce their market presence. The thorough analysis presents a wide-ranging comprehension of the global market in a knowledgeable way. The client can merely point out the steps of the firm by having details regarding their global revenue, market share, price, production & capacity, and recent developments during the forecast period.
Request Free Sample Report of Neuroscience Market Report @ https://www.zionmarketresearch.com/sample/neuroscience-market
Key players leveraging the business growth are
Alpha Omega, Axion Biosystems, Blackrock Microsystems LLC, Femtonics Ltd., Intan Technologies, LaVision Biotec GmbH, Mediso Medical Imaging Systems, Neuralynx Inc., NeuroNexus Technologies, Neurotar Ltd., Newport Corporation, Plexon Inc., Scientifica Ltd., Sutter Instrument Corporation, Thomas Recording GmbH, and Trifoil Imaging Inc.
The research report includes the outline of the global Neuroscience Market such as definition, classifications, and applications. Apart from this, it entails the comprehensive assessment of a number of factors like constraints, opportunities, drivers, challenges, and risk. Further, the global Neuroscience Market is bifurcated on the basis of diverse parameters into respective segments as well as sub-segments. The report also encompasses the existing, previous, and likely growth trends within the market for each segment and sub-segment[Product, Applications, End-Users, and Major Regions]. Additionally, the market is also segregated based on regions[North America, Europe, Asia-Pacific, Latin America, The Middle East & Africa].along with detailed evaluation of their growth, key developments & strategies, opportunities, and the key patterns influencing the market expansion in those regions. The report will further also entail a particular part putting forth the changes and of the ongoing COVID-19pandemic. It comprises-depth market analysis rooted in the predictions of post-COVID-19 market circumstances together with data on the existing impacts on the Neuroscience Marketof the pandemic.
Global Neuroscience Market: Regional Segment Analysis
The research report also highlights the wide array of tactical steps, such as the latest business deals, joint ventures, partnerships, M&As, technological developments, and the launch of new products taking place in the market. In addition, it scrutinizes several patterns of the global Neuroscience Market, entailing the rules, criteria, and policy deviations implemented by the private companies and government on the market over the last few years. As a final point, the analysis includes forecasts and historic data making it a beneficial asset for experts, industry executives, presentation, sales & product managers, consultants, and every other person or organization looking for essential market data and statistics.
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How Will Global Neuroscience Market React from 2021 Onwards? KSU | The Sentinel Newspaper - KSU | The Sentinel Newspaper