Anticancer drug may reduce mortality and speed up recovery for severe COVID-19 patients – News-Medical.Net

Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020. On average, blood oxygen levels, body temperature and inflammatory markers significantly improved in patients treated with a single dose of bevacizumab in addition to standard care. The research is published in Nature Communications.

To reduce COVID-19 mortality, we aim to develop an effective therapeutic paradigm for treating patients with severe COVID-19. Our findings suggest that bevacizumab plus standard care is highly beneficial for patients with severe COVID-19 and should be considered as a potential first-line therapeutic regimen for this group."

Yihai Cao, Corresponding Author, Professor of Vascular Biology, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet

Bevacizumab is a medication that has been used to treat various types of cancer since 2004. It works by slowing the formation of new blood vessels by inhibiting a growth factor known as VEGF. Many patients with severe COVID-19 have elevated levels of VEGF as well as symptoms associated with this marker, including excess fluid and disorganized blood vessels in the lungs. Against this background, the researchers designed a clinical trial to investigate the effect of combining bevacizumab with standard care for treating patients with severe COVID-19.

Twenty-six patients were recruited from two hospitals in China and Italy between mid-February and early April in 2020. The patients had confirmed COVID-19 and symptoms such as difficulty breathing, low blood oxygen levels and pneumonia. They were retrospectively matched with 26 patients of similar characteristics who received standard care at the same hospitals in roughly the same time period and thus served as the control group.

The recruits received standard care plus a single low dose of about 7.5 mg/kg bevacizumab, which markedly improved blood oxygen levels within 24 hours compared to the control group. By the end of the 28-day follow-up period, 92 percent of the bevacizumab-treated patients no longer needed the same level of oxygen support as before the trial began, compared with an improvement rate of 62 percent for the controls.

None of the bevacizumab-treated patients died and 17 (65 percent) improved so much that they were able to leave the hospital within the follow-up period. In the control group, three died and only 46 percent were discharged within 28 days. Bevacizumab also shortened the duration of oxygen-support to a median of nine days compared with 20 for the standard care group.

Other interesting findings include reduction in fever, an increase in white blood cells and a sharp decrease of c-reactive protein (CRP) levels, an inflammatory marker. No severe safety concerns were detected.

"Many patients with severe COVID-19 require significant oxygen support during long hospital stays, which pose global challenges to medical supplies," Yihai Cao says. "Our study shows that bevacizumab could help reduce the need for oxygen support and reduce days in hospital, thus improving the outcome for the individual patient while easing pressure on medical resources."

The limitations of the study include the non-randomized nature of the trial, the short-term follow-up and the small size of the cohort.

The next step will be to design randomized and placebo-controlled trials by recruiting a large number of patients, allowing further assessment of the potential benefits of bevacizumab both in and of itself and in combination with other therapies such as antivirals and anti-inflammatory drugs.

Source:

Journal reference:

Pang, J., et al. (2021) Efficacy and tolerability of bevacizumab in patients with severe Covid-19. Nature Communications. doi.org/10.1038/s41467-021-21085-8.

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USC scientist Ya-Wen Chen receives American Lung Association grant to advance stem cell-based lung therapies – India Education Diary

USC Stem Cell scientist Ya-Wen Chen hopes to pioneer a new approach to regenerating damaged lung tissue, with support from a Catalyst Grant from the American Lung Association (ALA). The award provides $50,000 year for up to two years.

For many patients with chronic lung diseases, the only available treatment is transplantationa difficult, dangerous surgery that involves challenges ranging from the severe shortage of donor organs to immune rejection, said Chen, who is an assistant professor of medicine, and stem cell biology and regenerative medicine at USC. Even patients who are lucky enough to receive donor organs only have a 10 to 20 percent survival rate at 10 years. If we can encourage these patients own cells to repair damage and heal their lungs, we could dramatically improve this prognosis.

With this goal in mind, Chen is using human stem cells to generate rudimentary lung-like structures known as lung bud organoids. Within these organoids, Chens group will probe how a specific population of cells repairs the tiny gas-exchange interfaces called alveoli in damaged lungs.

Specifically, Chen is interested in a population of cells known as distal small airway epithelial progenitors or SAEPs, which could have the potential to improve lung function in patients with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD). A group of lung diseases that includes chronic bronchitis and emphysema, COPD affects at least 16 million Americans and is the third leading cause of death in the U.S. An additional 200,000 Americans are living with IPF, a progressive, incurable and often deadly disease that, for unknown reasons, causes scar tissue to form in the lungs, impeding breathing.

Our ultimate goal is to leverage patients existing stem and progenitor cells to promote healing through a non-surgical, regenerative approach, said Chen, a member of the USC Hastings Center for Pulmonary Research, as well as USCs stem cell research center.

Chen is one of 98 scientists to receive research support from the ALA, which has committed $11.55 million total to support scientific investigations aimed at reducing the burden of lung disease.

Despite the fact that the pandemic poses significant economic challenges, said ALA President and CEO Harold Wimmer, the American Lung Association is prioritizing research and significantly increasing award funding to help improve the lung health of all Americans.

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Grey’s Anatomy: 5 Most Shameless Things Owen Ever Did (& 5 He Should Be Proud Of) – Screen Rant

Owen Hunt has been around for years on Grey's Anatomy, and he has several shameless actions under his belt - and others he should be proud of too!

Owen Hunt might not be a raging fan-favorite in the long-running hit medical drama Greys Anatomy but he has been one of the main characters since the shows 5th season.

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He started out as the quick-witted, striking trauma surgeon who had served in the military, althoughhis arc over the years has mostly been romantic, as he gotinvolved with several doctors like Cristina, Amelia, and Teddy. Like everyone else on the show, Owen has done a few things he should be proud of, and others, not so much.

Owen and Cristina were together for a long time, the second lead couple of the series after Derek and Meredith. However, although they did truly love one another, their romance went through several ups and downs and finallyhit a rocky patch that eventually led to their divorce.

Cristina went ahead with the abortion against Owen's wishes, and although she had every right to do so, it did hurt Owen deeply. The damage to their relationship became almost irreparable, and Owen went and cheated on Cristina with a random woman at a bar. While this was uncharacteristic of him, it was pretty low to somehow take revenge on Cristina by being unfaithful to her.

Owen is, of course, a world-class trauma surgeon and had served as a military doctor for several years before joining Seattle Grace.

Owen helped a lot of his comrades while serving in Iraq, and was shown to have been there for his dying friend, an incident that contributed to his post-traumatic stress disorder (PTSD). As a veteran doctor, Owen most definitely has a past to be proud of.

Owen let the doctors headed to Boise get into a chopper from a dubious charter company.

RELATED:13 Most Shocking TV Deaths of All Time

Although this was purely a mistake, Owens negligence was most certainly somewhat responsible for the doctors including Meredith, Cristina, Derek, going through that horrifying tragedy. Neither Lexie nor Mark survived the crash, Arizona lost a leg and the tragedy left an indelible mark on the others forever.

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Grey's Anatomy: 5 Most Shameless Things Owen Ever Did (& 5 He Should Be Proud Of) - Screen Rant

Grey’s Anatomy: 10 Ways Bailey And Warren Are Relationship Goals On The Show – Screen Rant

Everyone believes that Meredith and Derek are Grey's Anatomy's best couple when, in reality, it is Ben and Bailey. They define relationship goals!

Grey's Anatomy features many outstanding friendships and relationships. But so many of the relationships on the show are fought with strife, or fizzle out after explosive beginnings. However, there is one relationship that has managed to stand the testament of time: Miranda Bailey and Ben Warren.

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These two headstrong characters form an unbeatable team that defines the term "relationship goals" in the Grey's Anatomy universe. With many cute moments between them, and other moments that show the depth and strength of their relationship, here are some ways in which they personify the phrase "relationship goals."

Ben Warren was probably the first person to take on Miranda in such a fashion. He stops her from just making assumptions on his behalf and very straightforwardly tells her to ask questions, which will be answered by him. They make their boundaries clear, and their plans and intentions clear as well.

When Bailey is afraid that this might lead to them just ending up as friends, Ben makes it clear that they won't. The clarity of their conversation and the communication between them lay a strong foundation for their relationship. Their first kiss is therefore reflective of all this, while also being filled with intense chemistry.

It is very clear that Tuck is of utmost priority to Miranda. So the fact that Ben was able to connect to him, and actually bond so well with him was something that meant a lot to Bailey. The three of them formed a very cute family unit and they were family goals as well. Ben fits into the dynamic between Bailey and her son quite well and this is a very important factor that makes their relationship so strong.

It is such an adorable moment when both these parents freak out when Tuck says that he has a "thing" with someone and puts his arm around a girl. They both discuss their plan of action and make the decision together that Ben would give the 'talk' to Tuck.

RELATED: 10 Most Questionable Parenting Choices In Grey's Anatomy

This incident beautifully portrays their ability to be an incredible team and the strength of their relationship. And it's also a funny moment to see them both freak out in this manner.

When Bailey was struggling with her mental health, she asks to take a break from their relationship, wondering if it was Ben's job that was the thing giving her anxiety. But even when they were on a break, Bailey was constantly missing him and wanting him.

And even Ben couldn't stay away and boarded up the windows to their house when he knew about the snowstorm coming. Even when they are not technically together, they cannot but help but be concerned about each other.

The incredibly talented Miranda Bailey ends up being the first-ever female chief of the hospital. She is hardworking, persistent, and reaches heights that no one else had reached before.

Even though they had their fair share of highs and lows, Bailey excelled at her job and Ben was incredibly supportive of his high-achieving wife. They were quite the power couple with Ben being as ambitious as Bailey, albeit in different ways and in different trajectories of their career path as well.

The only issue Ben had with the situation was the fact that Bailey hadn't discussed the matter with him beforehand. Ben very quickly came to terms with it but they decide to never make big decisions without asking each other.

RELATED: Grey's Anatomy: 10 Couples That Shouldn't Have Worked, But Did

Both of these are very reflective of the strength of the relationship. And the very small fight they have with Ben sleeping on the couch, and the manner in which they make up so quickly and so well shows what a strong but also goodcouple they were.

Nothing goes to plan on their wedding day, with Bailey deciding to perform emergency surgery on Adele and leaving Ben waiting. But, unlike her earlier experiences with her ex-husband, Ben is completely understanding of the situation and is in no way even mildly annoyed by the delay.

The immense amount of respect they have for each other is quite evident here with Bailey's belief in doing her work, and Ben's belief in her priorities as well. And even though their wedding ends up happening quite late, it is still an incredibly enjoyable occasion and the love they share was celebrated.

The way in which the proposal played out was incredibly typical of this couple. Ben had taken so much time to pull off a very cute surprise proposal, but because of Bailey rushing out to surgery before finishing breakfast, it had fallen quite flat.

When Bailey finds out that she had sort of spoiled Ben's proposal, she pulls off her own version of a proposal which is quite extreme as well. They both ended up proposing to each other and it was a very funny thing to have happened to this resolute couple.

After their engagement, Ben has moved to California making their relationship a long-distance one. So whenever Ben is in town, they are constantly spending every waking moment together in the hospital - to the point that they become the talk of the hospital.

RELATED: 10 Funniest Grey's Anatomy Relationship Memes That Will Make Fans Laugh And Sob

Especially amongst the new set of interns who have seen this version of Bailey in their first year, they start referring to her as Booty Call Bailey. Despite the unruly nickname they gave her, it was incredibly sweet to learn how happy and so in love they are with each other.

Bailey and Warren's relationship is not very simple or dreamlike. It takes genuine work and commitment to keep it going. There have been many highs and lows in their relationship, with Ben changing his field, moving away, becoming a firefighter, Miranda's difficulty with mental health, and so on.

But despite it all, they chose to be with each other every single time and that is what makes their relationship quite amazing. They have both survived it all and they still love each otherbutthat's what makes them relationship goals on the show.

NEXT: Grey's Anatomy: Why Miranda Bailey Is Actually The Show's Main Character

Next Gilmore Girls: 10 Times Luke Said Everything Fans Were Thinking

Vandana is a twenty-something student from Kerala studying in Chennai, India pursuing her Masters in English Studies. She prefers writing because she's no good at the talking business. You can read some of her other rants at : http://wheneverhoweverwhatever.blogspot.com

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Anatomy of . . . snowboarder Katie Ormerod | Sport | The Sunday Times – The Times

The British snowboard slopestyle World Cup champion missed the 2018 Winter Olympics through injury but will be a medal hope at Beijing Games a year from now.

Balancing actOrmerod has been training on balance boards since she started snowboarding aged five. As a result, she has great influence over her own centre of gravity. Balance is one of the key ways to mitigate against injury but also one of the keys to success on the board

Brought to heelOrmerod broke her heel in two places in February 2018, only three days before she was set to compete in the Winter Olympics in Pyeongchang. The injury was so bad it took over an hour for her boot to be removed. Seven operations later, including

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Anatomy of . . . snowboarder Katie Ormerod | Sport | The Sunday Times - The Times

Military Metaphors in Health Care Are Harmful — Especially During the… – Truthout

As the COVID-19 outbreak continues to sweep through the U.S., many have noticed the coupling of military and health. Theres been an ongoing conversation amongst oncologists for years about the use of war metaphors in cancer research and treatment. In fact, many public health concerns are framed in these terms war on drugs or war on poverty, for example. Its argued the use of these metaphors help make it easier for our society to better understand health. But herein lies a follow-up question: why?

These metaphors are not as unconscious as wed think. Anthropologists have studied the ways immunological functioning is encased in war imagery. Emily Martin powerfully illustrates how our categorical and systemic understanding of immunology represents a police state. Invasions of foreign bodies and immunological cells coming to the defense mimic the kind of warfare we might see on TV. Here, scientific empiricism becomes a mere farce, and it is apparent many concepts are actually influenced by the larger socio-political sphere. Thus, the endless metaphorical wars begin to make more sense.

In a post-colonial world, militaries help secure borders and the interests of the global ruling class. Although always present, after September 11, there was a noted increase in the militarization of U.S. society as we moved to normalize the further militarization of police forces, the creation of new war technology and surveillance structures, justified under the guise of national security. The ongoing normalization of these frameworks has seeped into many facets of society, including health care. This past year, the co-option of military jargon to name health care workers as frontline soldiers thrusted them on a pedestal of heroism and honor. Moreover, National Guard soldiers were also deployed to assist with COVID-19 testing in predominantly working-class communities across several states when infection rates reached new heights in 2020.

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While this conflation appears benign, its contradictions are relentless. For one, it functions to obfuscate a dire reality, presenting a facade of order and control. Where language tells us health care workers were frontline soldiers, reality tells us individuals were scapegoated and thrust into battles with little help or support from the ones handing out proverbial medals. Where language tells us vaccine rollouts combatively coined Operation Warp Speed will bring an end to our viral misery, reality also illustrates a patchy distribution scheme and a lack of political will displayed by our state to enact the structural change we actually need to remedy the larger socio-political issues that led to the spread of COVID-19.

The marriage of health and military is also an ironic endeavor. While the National Guard was deployed to help with COVID-19 testing across the nation, it was simultaneously deployed on behalf of the state to support local police forces in quelling Black Lives Matter protests. National Guard members stood protecting government property, intimidating members of the public with large guns in their hands, while local police tear-gassed the protesting crowds. Its important to note many experts, including the American Thoracic Society, denounced the use of tear gas, specifically because of the increased ability for COVID-19 transmission with its use.

Furthermore, consider the countless images and videos circulated this past year of law enforcement gathering and handling crowds sans face masks, functioning in direct contradiction to Centers for Disease Control and Prevention guidelines and local state mandates. In addition, the rampant spread of COVID-19 in jails and prisons across the country was also linked to local authorities intransigence on offering prisoners proper protections and the inherent racism of our carceral system. Even budding concerns around safety protocols for those detained at Guantnamo Bay were inadvertently silenced by the state.

We must also consider the militarys hand in the surveillance of communities of color. From policies like Countering Violent Extremism programs, the Patriot Act and the monitoring of undocumented people by Immigration and Customs Enforcement, the consequences of these programs remain dire for communities of color across the country. We cannot ignore the harm potentially authorized by placing the responsibility of health care in the same institutions that rely on these dehumanizing structures.

Why are we so apt to allow the same institutions that harm and police our communities the room to conduct work that might serve to heal them? While the situation maintains complexity, there is no denying our compliance with this framework stems from societys inability to imagine a world without violence, even in terms of health and healing. From the staunch hierarchies fostered by these frameworks that warrant health care workers and generationally marginalized members of our society disposable for the supposed greater good, to the larger contradictions present on a global scale, its evident the normalization of this framework confirms our desensitization to the cost of human life.

If we are to begin reimagining a new world, it must include the undoing of these frameworks. At a time where we need deep healing, it becomes evident the marriage of military and health serves more to protect the interests of the state and less of our communities. We must begin critically engaging with how we teach about health and illness and who we are deeming as the authority on these initiatives. The collision of warfare and health blurs the lines between humanity and violence; it dehumanizes and distorts. An institution designed to police and destroy will never be our salve. We must reimagine new systems of health and healing for ourselves and our future generations ones that steer the structural change we need and dont require endless human sacrifice nor offer our oppressors the title of humanitarian.

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Pueblo Community College names its 2020 employees of the year – Pueblo Chieftain

Joe McQueen|The Pueblo Chieftain

Pueblo Community College has named four of itsstaff the school's 2020 employees of the year.

The faculty were given the award during PCC's virtual spring semester kickoff event. According to a news release, they were selected based on their professional excellence.

"I'm very appreciative and honored. My colleagues are the ones who nominated me for the award. It's really just an amazing group of people I work with," PCC academic excellence administrator Bonnie Housh, one of the award recipients, said. "Everybody helps everyone, it's been a good run."

MORE: Pueblo Pro Bono Mental Wellness program celebrates its 10th anniversary

Housh has worked at PCC for30 years, 22 of them as a part-time instructor in the science department. She said she enjoyed teaching during her time as a part-time instructor since her schedule worked out with raising a family.

"When you see the lightbulb go on for students when you're explaining anatomy and physiology and when they understand what you're talking about, that's just a great feeling," she said.

Health information technology program coordinator and faculty memberMarianne Horvath also was named an employee of the year. She has been with PCC for four years and received the award for her dedication to student success.

MORE: State hospital staff in Pueblo fear for safety with new policing plan

"It's a really amazing honor and certainly something I did not expect. Getting this award is kind of unbelievable," Horvath said.

She said she enjoys everything about the school andhow everyone rallies around the students to provide them the best education.

"Providing top-notch current content that they need to know to be successful in the workforce. PCC has assembled an arsenal of tools to help students with just about any need that comes up," she said.

The other award recipients included administrative assistant for Pueblo Corporate College Debbie Clement and mathematics instructor Nancy Hunt.

Chieftain Education Reporter Joe McQueen can be reached at jmcqueen@gannett.com or on Twitter @jmcqueennews

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Pueblo Community College names its 2020 employees of the year - Pueblo Chieftain

Ga. Parents Of Transgender Athletes React To New ‘Female-Only Sports’ Bill | 90.1 FM WABE – WABE 90.1 FM

Georgia LGBTQ advocacy groups are criticizing new legislation that they say discriminates against transgender youth.

Republican state Rep. Philip Singleton announced House Bill 276 on Thursday, along with 36 other House members who have already co-signed the legislation.

Singleton announced the bill would stop state public schools and universities from allowing biological males to participate in girl-only sports. If passed, HB 276 would also allow students to sue schools that deprive them of athletic opportunities, as a result of violating the law.

No one here is concerned with how any person chooses to identify their gender, Singleton said during a press conference in the Georgia Capitol building, alongside his family and other young, female athletes lined up behind him.

We believe every single athlete should have the opportunity to compete, and there is no place for identity politics, or discrimination of any type, in sports.

Singleton then introduced his 10-year-old daughter Emma and put her in front of the mic, saying the bill is about biology and physiology, not psychology or sociology.

I dont think it is fair for girls who are playing in girls-only sports to have to play against boys, she said.

The boys are naturally born stronger and can usually beat girls.

But one former Georgia politician is joining in with critics of the bill who say its a discriminatory, shameful attack on Georgias transgender youth and young adults.

Jen Slipakoff ran to represent Georgias State House District 36 in 2018. She said her daughter a young, transgender athlete in a conservative Georgia district would be devastated if the bill passes.

I havent told her. I havent told her because I dont know what to tell her, Slipakoff said in response to a question about her daughters reaction to HB 276.

What do you say to that? Theres some lawmaker who has never met a transgender person, probably, who thinks that you should not play? Who has never met you, and thinks you shouldnt play lacrosse with your friends? What a heartbreaking conversation.

The bill would force state universities to disregard NCAA guidance on transgender athlete inclusion.

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Ga. Parents Of Transgender Athletes React To New 'Female-Only Sports' Bill | 90.1 FM WABE - WABE 90.1 FM

Novel hybrid device to boost research on metastatic process of breast cancer cells – News-Medical.Net

European researchers are working on a novel hybrid device to better understand the metastatic process of cancer cells traveling from breast to bone and fast screen new drugs against it.

The spread of cancer cells to other parts of the body, known as metastasis, is the main cause of cancer-related deaths. According to the US National Cancer Institute, in 2018 there were 9.5 million deaths caused by cancer worldwide, and a high percentage of those involved tumors that had spread across the body.

However the metastatic process remains one of the most enigmatic aspects of the disease. To understand it, we have to take a step back and look at the biology of the primary tumor.

Roger Gomis, head of the group growth control and cancer metastasis at the Institute for Research in Biomedicine, in Barcelona, explains: "Essentially what you have in a tumor is an original cell or a small group of cells that receive oncogenic signals, such as tobacco or UV light. Those inputs induce alterations known as mutations, which make the cells start proliferating in a dysregulated manner. The tumor mass starts growing and expanding and, in order not to run out of supplies and collapse, some cancer cells spread to other organs. Cancer cells spread not because they are encoded to the metastasis but just because it's crowded."

What we observe in cancer is an accelerated process of evolutionary species, trying to leave one site to grow on foreign soil. The site where tumor cells metastasize is not random, it rather follows a specific tissue pattern based on the Darwinian theory of evolution.

Gomis uses the Galapagos Islands as an example to explain. "You have a population of birds that have flown from Ecuador. They reach the islands and they adapt to the conditions of each island, forming new bird species. Why did birds colonize the Galapagos Islands and not dogs or reptiles? Because they could fly! So the genetics made them the candidates. But then, there is a process of adaptation that is imposed by the characteristics of the destination; for example the latitudes and where the food is," he says.

In terms of metastasis, it is the same. The fact that metastatic cells metastasize on a particular site depends on the genetics of the cells, the characteristics of the metastatic tissue and the ability of the tumour cells to adapt to and grow in the new environment. A great example of this is breast cancer.

The bones are the most common place where metastatic breast cancer cells tend to go. Although the research on tumors has exponentially grown in the past years, the major hurdle to decreasing mortality is to find out where the cancer cells will spread. To understand the process, scientists need relevant cancer models, which are lacking.

The main reason why it has been so difficult to translate the findings into the clinical settings is that the models of the laboratory sometimes do not factor in everything we have in the clinics. The laboratory mice, in terms of metastasis, do not always recapitulate what we see in the patients. For example, the breast cancer that we generate in the mouse tends to metastasize to the lung but it's rare to see it in the bones."

Roger Gomis, Institute for Research in Biomedicine, Barcelona

Providing better models to shed light on the bone metastatic process is the aim of the B2B project, supported by the EU Future and Emerging Technologies (FET) programme. Its interdisciplinary consortium are creating a cutting-edge device that mimics the spontaneous metastasis process from the breast to the bone.

Their innovative technology includes a patient-derived breast cancer lesion connected to a reconstructed bone via a complex vascular network. "The fluidic system mimics the features of human blood vessels feeding and connecting living tumour cells from breast cancer to the target metastatic tissue, which is the bone," explains Silvia Scaglione, group leader of the CNR-IEIIT Bioengineering laboratory of Genoa, and coordinator of the project.

The level of physiological complexity of the project is really high but this is necessary if we are to capture all the key elements of the metastatic process. "Usually cancer is studied either using in vitro static models or in vivo animal models. However, both approaches fail to recapitulate the metastatic process for different reasons. The static model can't mimic the fluidic connections between the breast cancer and the metastatic side, while the animal model doesn't resemble the spontaneous breast metastatic onset," she says.

If successful, the B2B device will be an in vitro alternative that features three new complementary technologies. The first is clinically relevant-sized organoids that are able to resemble what is happening in vivo. "If you miniaturize too much the cancer tissue, as in some other in vitro approaches, you lose some biochemical and molecular features such a hypoxic core within the tumor tissue," Scaglione explains.

The second is the generation of the ossicle, the bone tissue containing the target of metastasis, in vitro. "We started using mice models to make the ossicle, since it is impossible with our knowledge in the world to create the bone marrow, which is the target of the metastatic cancer cells. In parallel, the partner involved in this task is working on a novel in vitro approach using patient-derived stem cells to create bone tissue and thus by passing completely the animal step," says Scaglione.

The third is the fluidic system that connects the breast and bone tissues, which is entirely based on human physiology. The system consists of a micro-vascular capillary network, which is formed spontaneously around the tumour tissue, connected to a functional bioprinted macro-vascular tree.

Scaglione sees a future whereby any crosstalk between organs can be studied using the B2B platform, reducing the need for animal models and supporting scientists in advancing knowledge on tumors. "We have selected the breast metastasis as a case study but, of course, our platform will be adapted for many other diseases," she says, "Not necessary for cancer, but, for instance, fibrosis or other cases where you have an interaction between different tissues that are vascularised and fluidically connected. Also, the platform will be useful for studying the pharmacokinetics of any type of drugs."

Scaglione also believes that this technology will accelerate the identification of metastasis-suppressing therapies for breast cancer patients and will help pre-screen novel personalized cancer therapies, which will ultimately have a high impact for oncological patients.

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Groping in the Dark for Answers: An Interview with Femi Kayode – Los Angeles Review of Books – lareviewofbooks

FEBRUARY 4, 2021

MY CONVERSATIONS WITH Femi Kayode that have taken place in the past few months have been via the virtual world WhatsApp, Zoom, email, etc. but Femis fizzing positive energy cannot be contained by a screen. He is the old friend you didnt know you had, and it was my pleasure to interview him for his debut novel, Lightseekers.

In Lightseekers, Philip Taiwo is a psychologist who has returned to his native Nigeria. He is persuaded by a grieving father to investigate the necklace murders of three young men in a fictional community on the outskirts of Port Harcourt. The debut contains many of the elements that are the norm for crime fiction, while also addressing some of the complexities and challenges that communities in Nigeria face. Its an example of genre fiction that brings to light the cracks in our society and those individuals who fall through them.

OYINKAN BRAITHWAITE: As I read Lightseekers, I was drawn in by how particular mob justice is to Nigeria and climes like ours. Was there a specific incident that inspired this story?

FEMI KAYODE: The Aluu 4 incident, where four undergraduate students of the University of Port Harcourt were tortured and burnt to death, really stuck with me. By then, necklace killing, as it is known all over the world, was a common occurrence in Nigeria and several parts of the continent.

This one was different, though. Perhaps it was the very public nature of murders, with several people posting videos of the killing on social media. Or the fact that these boys could not have been strangers in the community where they were murdered after all, they were students of the very university that was the lifeblood of the town. Anyway, it really made me wonder: what could drive people to do this to another human being? I wondered how the parents of the students are feeling. It was one thing to know your child died, but to have graphic and on-the-loop evidence of how, must be unbearable. Then, of course, I thought of the mob: neighbors, friends, colleagues, fellow tribesmen, family, and more. How did they see themselves the next morning after the incident? Did they high-five each other and congratulate themselves on a killing well executed? Or did they pretend nothing happened and go about their businesses?

Most of all, the more I read about the Aluu 4 killings, the more I could see that the town itself was a kind of microcosm of the whole country, and that what happened in that university town could happen anywhere because, in essence, the same conditions applied: insecurity, poor infrastructure, failure of leadership, unregulated social media, outdated legal structures, poverty, and so much more. I think these questions and more were what inspired the story in the form that it is now and gave me the what if that is the premise of any work of fiction. Because in the final analysis, that is exactly what Lightseekers is, a work of fiction.

The protagonist in this case isnt a policeman or a detective (which his wife is quick to point out), but a psychologist. Why this profession?

As a student of psychology, I have always been fascinated by the why of human behavior. I didnt think a detective or police officer would shed more light on the story the way I wanted to tell it. Having a protagonist who had exactly the same kind of questions that I, as a writer, had helped me to explore and tell an authentic story that went beyond the classical procedural.

The fact that he is not a professional investigator also helped me to allow him to make the same kind of mistakes anyone would make in such a setting. I think it made him accessible, some kind of everyman with the most fundamental skill needed to be human: empathy.

At the heart of it all is the kind of psychologist Philip Taiwo is. He is an investigative psychologist and not a clinician this means while he might have insights into the human mind and its pathologies, he is not equipped to diagnose or treat. First and foremost, he is an expert at uncovering motivations, explaining a crime, and ensuring that the solving or investigation of such a crime is unbiased toward the innocent while being ethically fair to the guilty. He is really the kind of expert witness that either side of a criminal investigation can call on to shed more light on what appears to be obvious but defies understanding. This profession, to my mind, was the perfect one for my protagonist as it reflects my own need to understand a lot of what goes on in my country! Hence, I still say writing Lightseekers was a therapy of sorts for me.

Did your training as a clinical psychologist make it easier or harder to write this book? How much research did you do?

My training gave me the insights into what questions to ask, and the aspects of human behavior I wanted the protagonist to explore, but it didnt make it harder or easier to actually write. In front of the keyboard, I was merely a storyteller, armed with selective information that I was using to drive my point. Of all the skills and training that I had, I would say it is the screenwriting one that had the most impact on my writing I wanted to write an engaging and visual story that immersed the reader, and I knew the only way I could do that was to see the characters and their actions as visually as if I was watching or directing a movie.

I had a wonderful researcher in a good friend of mine who is also a writer and a lawyer. My research was essentially me reading tons of articles on the internet, then sending them to him to read with tons of questions around four systemic realms: political, economic, social, and technological. When I had questions regarding some of the psychological hypotheses I was toying with, I would of course share these with him to be sure they were plausible assumptions. The fact that he is a writer really helped because we could work fast speak in codes even and by the time I had the semblance of a story, he was able to highlight key elements that worked and those that wouldnt. When I was three-quarters into writing, I decided that the internet and email correspondence with my researcher was not enough, so I traveled to Port Harcourt. My researcher and I spent a wonderful week driving around, interviewing people, and just soaking in the sights and sounds of the region. It was the most effective piece of research I did, despite having decided early on to base my story on both a fictional town and university.

I am not sure I do so well with research or what you can call a faithful adaptation of what really happened, like Capotes In Cold Blood. There was a time when the facts of the different necklace killings and what motivated them held me back. I was only able to really be free to imagine, and write what I wanted to write, when I decided to make the whole story a hundred percent fictional. When I took that route, research became almost anecdotal, and not as integral to the telling of the story.

You mentioned that your screenwriting skills were at play when you were writing your debut, and I can certainly see that at work in the novels four-act structure and in how easily I could picture the various scenes; so it comes as no surprise that your novel was recently optioned for film! Congratulations! Any thoughts on who you would like to play Philip Taiwo?

Maybe because I was studying in the UK at the time of writing, or because this particular actor was in a show that I found quite moving and profound at the time, but a British actor named Adrian Lester always resonated with me. I am a big fan of authenticity in storytelling and I do believe that with the rise in the diversity of the global film industry, it should not be hard to cast a show like this with Nigerian actors. David Oyelowo comes to mind. I once saw him imitate his (Yoruba) dad at a Q-and-A and I just cracked up. He will make a credible Philip Taiwo. Another character that is very strong in my mind is Chika, and the one person I see is the stupendously talented Nnamdi Asomugha.

Lightseekers is the title you chose for your debut, and at the beginning of each act is a statement about the behavior of light. Is it a metaphor for truth, or is there something more at play here?

Definitely a metaphor for truth. And knowledge. And how these can change color, shape, or even perspective depending on how light falls on them. Of all the parts of the book I am most proud of, it really is how readers get this almost instantaneously. There were many drafts of the book, but the two constant things were the title and those laws of light at the beginning of each act.

The mental fragmentation of the villain is also dramatized through the metaphor of light and dark. This is a reference to the broken system(s) that allow such a heinous crime (necklace killing) to be perpetrated with little or no consequence.

However, there is a much more localized nuance that I am hoping the Nigerian reader gets, and that is the idea of light to mean electricity. A significant portion of the action in the book happens during blackouts (which as you know, are quite the norm in the country). I tried to heighten the tension by literally dramatizing the frustration of groping in the dark for answers. I am hoping it works.

Which of your characters did you most enjoy writing and why?

My villain was really difficult because I had so much information on him in my head, but I could only use very little of that in the book. I think it was the part I fought the most for, and had to make work to keep. I was allowed a limited word count for him, and that meant every word needed to drive the story forward. So, writing him was quite challenging, and frankly fun.

I loved writing Philips wife, Folake. Her combination of strength and vulnerability fascinates me. There is also a wisdom and practicality to her that plays off Philip very well. There are several layers to her that are still unexplored, and I am going to enjoy writing more of her in the coming books.

But the most fun I had was writing the relationship between Philip and Chika. I really wanted to capture an authentic relationship between two very different men, and the evolution of a friendship that could only be fully realized through truth and openness.

Have you had any negative criticism/feedback, and if so, how do you handle it?

Heres how I see it: a writer who does not expect negative feedback is like a boxer who gets in the ring and does not want to get punched. I received tons of negative feedback from the second I placed early drafts in readers hands. I got it from agents when I was seeking presentation, from classmates, tutors, family, and friends. My wife especially did not mince her words. So, how do I deal with it? Like a boxer, I take the punch, retreat to my corner, and re-strategize how to get back in the ring, swinging.

Usually, if there is a common thread across the feedback from two or three readers, I take it very seriously. With the book published now, I cant fix anything, so a lot of the negative (constructive) feedback I am getting is affecting how I approach the sequel that I am working on now. Is there feedback that kicks you in the gut and make you feel like throwing in the towel? Absolutely. But those ones, literally aimed at your core competence, determined to destroy, are the very ones that you should shrug off. Any critique that does not aim at making me better is not, and should not, be worth my time or consideration.

What advice would you give aspiring authors?

Writers write. No one will know if youre any good unless there are actual words on a page to read.

Trust the writing process to make sense of the mess in your head. The power of words lies in their ability to simplify to effectively communicate. Use it.

Most of all, write in love. Love for the characters good or bad, and the story. Love for the reader, for the craft, for humanity. An unconditional compassion for the human condition is the one true gift I believe a writer can give the world.

Oyinkan Braithwaite is the author of My Sister, the Serial Killer.

See more here:
Groping in the Dark for Answers: An Interview with Femi Kayode - Los Angeles Review of Books - lareviewofbooks