OU Professor Barbara Oakley named one of ’35 Highly Influential Women in Engineering’ – 2021 – School of Engineering and Computer Science – News – OU…

Oakland University Professor Barbara Oakley has been selected as one of the 35 Highly Influential Women in Engineering Today by AcademicInfluence.com.

It was very much a surprise to be honored as one of the highly influential women in engineering, said Oakley, a distinguished professor of engineering at OU. All I can say is that Oakland University has clearly been a great intellectual home for me, allowing me to look with fresh, interdisciplinary perspectives at the best of what science, and especially neuroscience, has to help us reseat education on a solid scientific foundation.

The list also includes groundbreaking roboticists, founders of high-tech companies, CEOs, astronauts, medical experts, and pioneers in engineering sub-disciplines like computer science and electrical engineering, as well as revolutionary thinkers in areas like nano-medicine and nuclear power.

Engineering has a reputation as a mostly male profession, said Dr. Jed Macosko, academic director of AcademicInfluence.com and professor of physics at Wake Forest University. We want to set the record straight and let more people know that women engineers are not only growing in number; but are also driving the field forward in new and creative ways. They bring innovative thinking and bold solutions that make their professions better; and more people need to know who they are and see why they are the vanguard of a new era in engineering.

Professor Oakley is both a revolutionary and true innovator in the area of pedagogy and is recognized as one of the worlds leading experts in learning, especially in the STEM (Science, Technology, Engineering and Mathematics) disciplines, and in the design of high-quality online pedagogical materials.

Since joining Oakland University in 1998, she has made significant contributions as a productive scholar in the areas of STEM pedagogy, neuroscience and social behavior. Her books have been translated into over 20 different languages around the world.

She has also pioneered important work that has significantly helped the Academy understand what impacts a persons interest in subject matter, along with what affects their ability to master mentally difficult material. Of the 10,000 MOOCs (Massive Open Online Courses) currently available worldwide, her course,Learning How to Learn, is one of the worlds most popular with over 3 million registered learners from over 200 countries.

My goal is to open career doors for all students when it comes to engineering, especially those coming from disadvantaged backgrounds, Oakley said.

In recognition of her exemplary course materials and approach, Oakley was honored as Courseras Inaugural Innovation Instructor in 2015, is the recipient of the IEEE William E. Sayle II Award for Achievement in Education, the Theo C. Pilkington Award for Biomedical Engineering Education, Michigan Distinguished Professor of the Year, and the Oakland University Teaching Excellence Award. She was appointed to the rank of distinguished professor in February 2021.

For more information about this years 35 Highly Influential Women in Engineering Today, visit academicinfluence.com/rankings/people/influential-women-engineers.

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OU Professor Barbara Oakley named one of '35 Highly Influential Women in Engineering' - 2021 - School of Engineering and Computer Science - News - OU...

UCI Podcast: The perils and benefits of dream incubation – UCI News

It sounds too crazy to be true: Corporations and scientists using sounds and smells to influence peoples dreams. But targeted dream incubation is not limited to the realm of science fiction. Scientists use the method to help patients overcome addictions such as smoking, and corporations have launched advertising campaigns that encourage willing participants to participate in having their dreams shaped.

Sara Mednick, a professor of cognitive neuroscience at UCI, is worried about the potential misuse of dream incubation and recently joined about 40 other sleep and dream scientists in signing an open letter voicing their concerns. In this episode of the UCI Podcast, Professor Mednick discusses how dream incubation works, and how sleep keeps people healthy.

In this episode:

Sara Mednick, professor of cognitive neurosciences

Sleep and Cognition Lab, Professor Sara Mednicks lab

Advertising in Dreams is Coming: Now What? an open letter signed by about 40 sleep and dream scientists raising concerns about dream incubation, as used for advertising

Spend Saturday Night Dreaming With Zayn Malik, a press release from February 2021 announcing an advertising campaign by Molson Coors to encourage people to participate in targeted dream incubation

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AARON ORLOWSKI, HOST

When the sleeping mind hears certain sounds or smells certain odors, the landscape of dreams shifts. Some memories are reinforced, while others grow dim. By manipulating sounds and smells, scientists and corporations are able to influence our dreams and thus our waking lives.

What are the dangers and benefits of this kind of targeted dream incubation? And how do our dreaming hours keep us healthy?

From the University of California, Irvine, Im Aaron Orlowski and youre listening to the UCI Podcast. Today, Im speaking with Sara Mednick, a professor of cognitive neuroscience at UCI.

Professor Mednick, thank you for joining me today on the UCI Podcast.

SARA MEDNICK

Thanks for having me, Aaron

ORLOWSKI

So you, along with about 40 other sleep and dream scientists, recently signed an open letter raising some alarms about a new type of advertising called targeted dream incubation. Listeners might have heard of this because Molson Coors, the beer company, generated a lot of headlines about this back in January and February when they announced a plan to use this advertising method around the Super Bowl. So I want to ask you: What is dream incubation and how does it work?

MEDNICK

The first thing to kind of understand is that sleep is a time when we are processing our recent experiences and were folding them away and putting them into long-term storage areas where they can be safe and not overwritten by the next days experiences. The idea that you could kind of interfere with this memory processing time or this sleep time has been talked about for a century, at least. But it wasnt until about 15 years ago, 10 years ago, when researchers realized that if you pair the thing that you want to remember with a specific sound while youre trying to learn it.

So if youre trying to learn the position of a lot of different objects and where they go in a puzzle and each puzzle piece has an objects face on it like a cat or a tea kettle or a dog or a car. And all of these objects have a specific sound. The cat sounds like a meow and the dog sounds like a ruff, right? And every time you place that cat puzzle piece in the specific position it goes into the puzzle, you hear the meow sound. So you tie that sound to that position in the puzzle. When you then go to sleep, you play the meow sound, right? And you play say, maybe theres a hundred puzzle pieces. Maybe you play only 50 of those puzzle pieces. And then you wake up the next day and you see how many of those puzzle pieces do you remember their location? It turns out that those sounds that you played in the middle of the night, biased that memory processing to actually only focus on the puzzle pieces that had the sound played. It reactivated specific memories, and it made the memory process focus on only those memories.

And so what happens is your performance for just the memories that you reactivated during sleep. Well, Coors decided that they could use this idea in order to make you have an association between the Coors beer and very specific sounds that were the sounds of a mountain stream or birds chirping or beautiful like very refreshing feelings and sounds. And then when they went to sleep, the subjects were played those sounds again, and woken up, right after they were probably dreaming for awhile with those sounds in their heads. And they asked them, well, what were you dreaming about? And they were dreaming about Coors.

ORLOWSKI

Wow. So this could work for any variety of objects or subjects or ?

MEDNICK

Yeah, anything you can pair a sound to. But it doesnt just have to be a sound. It could be a smell. If there was a specific thing that you wanted somebody to associate, we could use targeted memory reactivation, where we target specific memories to be reactivated during sleep. And we can increase peoples memories. But its also been shown that we can actually make people forget certain memories by doing this targeted memory reactivation. So its like a targeted forgetting, very similar to the Spotless Mind movie, where people were trying to take out memories of long lost loves that they missed, their heartbreaks. And you could actually take out that memory. Well, this is exactly that idea that you can actually during sleep, instead of remember things more, you can actually delete things.

ORLOWSKI

That is crazy. And the movie Eternal Sunshine of the Spotless Mind was quite trippy. And if I remember the characters wanted to reverse their forgetting in the end.

MEDNICK

Yeah. Its, I mean, theres just a whole bunch of potential things that it can be used for, that some of them are really great. Theres beautiful research looking at people who are smokers who want to stop smoking. And during sleep, they send in the smell of cigarette smoke into the noses of the sleeping subjects. And at the same time, they pair that smoke with the smell of rotting fish. And what they find is that that creates a negative association with the smoking. And when people wake up in the morning, they dont want to smoke.

ORLOWSKI

So this sort of dream manipulation and memory adjustment, can be used for different purposes, helping an addict overcome their smoking addiction. But also we just talked about Coors using it to encourage people to want to drink more beer. So why are you concerned about this method being used by corporations?

MEDNICK

You know, back in the day before we knew about subliminal messaging manipulating people unconsciously to buy products, there was a lot of advertisements that were sent very quickly through films and you couldnt even see them and suddenly youve got the urge to drink Coke, you know, or eat more popcorn, or whatever it was. And that was outlawed because its unfair. Its unfair that people unconsciously are being driven to do things that they dont even realize that theyre being manipulated to do. So thats, thats that thats been regulated by this point. And those rules only really actually applied to waking experience. And the thing about the law is that you need to actually be very specific or people will get around it. You need to really say, okay, you cant do the subliminal messaging, either in wake or sleep.

And particularly because sleep, youre actually even more vulnerable to messaging than you are during wake, because youre sleeping. You dont remember anything. Subjects never remember that they had sounds played or smells played. And so you have no sense of when youre being manipulated or not. The Nest system has an algorithm that knows when people are sleeping in that room. And if thats the case, then they could also play music, they can play whatever sounds that they want. And so its not a far shot to say that if you know when someones asleep, you can add information into their sleep that would be unbeknownst to them.

ORLOWSKI

Well, so weve been talking a lot about the potential nefarious uses of this type of messaging in peoples dreams, but maybe we can talk a little bit more about why people dream in the first place. What function does it serve for people to have dreams?

MEDNICK

Its a great question. And if you find out the answer, I hope Im the first person that you tell. Nobody knows. Weve been trying to figure out this question for centuries. And its one of the earliest questions known to man and woman, because weve always dreamed. Evolution hasnt pushed it away and we still dream. And we still dont know why. Theres many hypotheses. You know, Im a cognitive scientist, so I look, maybe those dreams that are helping you rehearse the information that you just learned during the day. And that may help you with that long-term storage mechanism I was talking about.

You know, dreams also have emotional content to them. And so theres an idea that while youre dreaming, youre actually rehearsing and playing out certain kinds of scenarios. Maybe youre saying, well, what would I do if an ax murderer was running after me? Like, hmm, let me see that again you know, like these recurring nightmares. Like, what would I do in this case where somebody dumps me or whatever it is. And so you have these kinds of recurrent scenarios in your mind to see, like, what are different potential strategies and outcomes that I could choose?

At the neuroscience level, the idea is that with emotional experiences, we are uncoupling the emotional areas of the brain from the memory areas. And over time, these experiences that are at first rather really emotional actually become less emotionally charged and more kind of cognitively charged, where we can start to think about them a little more rationally over time. And thats a very natural process that happens with emotional experiences and it requires sleep to have a natural progression such that, you know, eventually that breakup that you thought youd never recover from in a month, youre like, yeah, all right, well, I did this wrong or, you know, she did that wrong, or whatever it was that you want to say.

ORLOWSKI

Yeah. Unless youre in Eternal Sunshine of the Spotless Mind, in which case you just regret it eternally,

MEDNICK

And then you just keep making the same mistakes over and over and over.

ORLOWSKI

Yeah. Well, so it sounds like sleeping and dreaming essentially helps us heal. So how does our mood change after weve slept or after weve dreamed?

MEDNICK

Theres obviously the idea of sleep on it youll feel better in the morning. And it turns out that sleep may help you feel worse in the short term and better in the long-term. And you could imagine why, right? If something happened to you while you were walking home, you know, you decided to take the darker route home, and something happened to you, you dont want to just forget that thing. Its actually really protective to have a strong, emotional response to a negative experience. And what has happened is you actually have a stronger emotional response right after you wake up in those first few days. Youre really living inside that emotional response. And then over time that emotional response starts to waiver or just decrease. And what you get is this stronger and stronger cognitive response. Those are really natural protective mechanisms that teach us not to do these things that didnt work out anymore.

ORLOWSKI

Yeah. Well, you mentioned earlier that we are especially vulnerable to messaging while were asleep and, and more so than when were waking. And I guess on one level that seems kind of intuitive, but can you tell us more about why thats the case?

MEDNICK

Many people wake up and they have no idea what they dreamed, right? Your hippocampus is a brain area that takes in new information. And sometimes its, its on, a of the times its on during sleep, but the part of the brain that really connects to the long-term memory and to really storage and to holding on the information, is also the frontal cortex. And the frontal cortex when youre sleeping is totally turned off. So you may have this connections to what recently happened and then what happened 10 years ago to you, and you have these dreams that are making wild connections between all these different experiences and that recent thing that just happened to you.

But when you wake up in the morning, you dont remember any of these things. And thats probably a good idea, right? Because you really want to focus on the things that are real. And the dream time may be some subconscious practice that youre getting through, some process that youre working through. But you dont want to hold onto your dreams per se, more than your waking life. So its actually sort of evolutionarily better to not necessarily be carrying your dreams around all day, but that also means that you dont know what happened to you in the middle of the night, if your dreams were suddenly full of Coors commercials.

ORLOWSKI

Yeah. You might not know how that got there, how those arrived.

MEDNICK

Yeah, you definitely wouldnt.

ORLOWSKI

Yeah, well, and I want to ask you one final thing. If I just want to get good sleep, what steps should I take? Youve studied many people or many components of sleeping and how to increase quality sleep. So what are the best actions to take?

MEDNICK

Theres so many different things that can be done. And theres a whole list of any website will tell you what sleep hygiene tips to take. But some of the ones that dont necessarily get recommended, but I recommend is getting to sleep early. Because the sleep that you get in the first part of the night is different than the sleep that you get in the morning. So the idea that you can get to sleep late and then sleep a little bit later in the morning, youre not actually getting the sleep thats the really good sleep. Whats called slow-wave sleep happens in the first part of the night. And thats the stuff that does all the clearance of toxins from the brain. And when people get older, they have less and less slow-wave sleep and more and more buildup of these toxins that can lead to the plaques that develop with Alzheimers. And also a lot of this memory consolidation stuff that weve been talking about all happens during slow-wave sleep. So really getting to sleep early, Im talking like 10 p.m., is very important for getting that early deep sleep that is the most restorative that we have.

Another thing is to make sure that when you wake up in the morning, you go outside and you get some sun. We are rhythmic animals and the sun is the strongest whats called entrainer, basically. Its the downbeat for our day. And when you get bright light early in the morning, that sets you up to actually be ready for sleep at night. And if you dont have bright light, maybe its the winter time and youre on the East Coast or something, get one of these really strong all spectrum lights and just have it for 15 minutes on while youre having your breakfast in the morning. I could go on and on, but reduce blue screens after 6 p.m. The blue light is really strong inhibitors of melatonin, which is a sleep hormone. And so you want to make sure that after 6 p.m., youre really trying not to get in front of any fluorescent lights or any lights that dont have some filters on them.

ORLOWSKI

Professor Mednick, thank you so much for joining me today on the UCI Podcast.

MEDNICK

Thanks for having me. It was super fun.

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UCI Podcast: The perils and benefits of dream incubation - UCI News

A new class of memory cells discovered in the brain – Tech Explorist

How the brain recognizes the faces of familiar individuals has been important throughout the history of neuroscience. But the proposed cells that link visual processing to person memory are not found yet.

A new study reported the discovery of such cells in the brains temporal pole region that links face perception to long-term memory. Scientists from the Rockefeller University have a new class of memory cells that collectively remembers faces.

Scientists used fMRI as a guide to zoom in on the TP regions of two rhesus monkeys. They then recorded the electrical signals of TP neurons as the macaques watched images of familiar faces and unfamiliar faces that they had only seen virtually on a screen.

When subjects had seen familiar faces, their neurons in the TP region were highly selective. After processing the image, these neurons found to fastdiscriminating between known and unknown faces.

Strangely, these cells responded threefold more strongly to familiar over unfamiliar faces despite the fact that the subjects had seen the unfamiliar many times on screens.

Neuroscientist Sofia Landi, first author on the paper, said, This signifies the importance of knowing someone in person. Given the tendency nowadays to go virtual, it is important to note that faces that we have seen on a screen may not evoke the same neuronal activity as faces that we meet in person.

Winrich Freiwald, professor of neurosciences and behavior at The Rockefeller University, said,The cells of the TP region behave like sensory cells, with reliable and fast responses to visual stimuli. But they also act like memory cells that respond only to stimuli that the brain has seen beforein this case, familiar individualsreflecting a change in the brain due to past encounters. Theyre these very visual, very sensory cellsbut like memory cells. We have discovered a connection between the sensory and memory domains.

The discovery of the TP region at the heart of facial recognition means that we can soon start investigating how those cells encode familiar faces. We can now ask how this region is connected to the other parts of the brain and what happens when a new face appears. And of course, we can begin exploring how it works in the human brain.

In the future, the findings may also have clinical implications for people suffering from prosopagnosia, or face blindness, a socially isolating condition that affects about one percent of the population. Face-blind people often suffer from depression. It can be debilitating because in the worst cases, they cannot even recognize close relatives.

This discovery could one day help us devise strategies to help them.

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A new class of memory cells discovered in the brain - Tech Explorist

There’s A Simple Way To Feel Happier, According To The New Science Of Emotion : Shots – Health News – NPR

Back in the fall, Michelle Shiota noticed she wasn't feeling like herself. Her mind felt trapped. "I don't know if you've ever worn a corset, but I had this very tight, straining feeling in my mind," she says. "My mind had shrunk."

Shiota is a psychologist at Arizona State University and an expert on emotions. When the COVID-19 crisis struck, she began working from home and doing one activity, over and over again, all day long.

"I will be honest, for the past 14 months, I have spent most of my waking hours looking at a screen, either my laptop, my phone or a TV screen," she says, often from the same sofa, in the same room in her San Francisco home. All that isolation and screen time had taken a toll on Shiota.

During the pandemic, many people have felt their mental health decline. The problem has hit essential workers and young adults, ages 18 to 24, the worst, the Kaiser Family Foundation reported in May. The percentage of adults with signs of anxiety or depression has grown threefold, from about 10% to 30%.

Although some people are starting to test the waters of public life again, planning vacations and socializing more, others may still have lingering signs of what psychologists call languishing. They may feel an emptiness or dissatisfaction in day-to-day life. Or feel like they're stuck in weariness or stagnation.

Luckily, an emerging area of brain science has a new way to help lift yourself out of languishing and bring more joy into your life. It worked for Shiota.

"I had to expand my consciousness," she says. And she did it by intentionally cultivating a particular emotion.

Explore ways to cultivate well-being with NPR's Joy Generator.

For thousands of years, there's been a common belief in Western culture about emotions that they are hard-wired and reflexive, psychologist Lisa Feldman Barrett writes in the book How Emotions Are Made: The Secret Life of the Brain. "When something happens in the world ... our emotions come on fast and uncontrollable, as if somebody flipped a switch," she writes.

But when researchers look at what's going on inside the brain and inside the body during specific emotional states, the theory doesn't hold up.

Over the past decade, neuroscientists have begun to shift how they think emotions arise. Rather than being inevitable, hard-coded experiences, researchers now think emotions are malleable, and people have more influence over them than previously thought.

Say for example, you're walking in the woods, and you see a grizzly bear, says neuroscientist Anil Seth at the University of Sussex. "You recognize it's a bear," he says, "and then what happens?"

Previously researchers thought the emotion comes first. "You see a bear and then you feel afraid," Seth says. "Because you're afraid, your brain then jacks up your adrenaline levels."

Your heart rate rises. Your breath quickens. Your pupils dilate. And blood rushes to your skeletal muscles. The old theory was that "the fear sets in train all kinds of flight and fight responses so that you are well-prepared to run away and live another day," he adds. In other words, the emotion (i.e., fear) triggers the physiological responses (i.e., an adrenaline rush).

But according to the latest research, the human body probably works the other way around, Seth says. "The brain registers a grizzly bear, and that perception sets in train all the physiological responses." You get an adrenaline rush. Your heart rate goes up. You start breathing faster. Blood rushes to your muscles. And then the emotion comes.

The brain senses these physiological changes and decides which emotion to conjure up. The emotion is an interpretation of what's going on both inside the body (the adrenaline rush) and the outside of the body (the sight of the bear). "The brain has to figure out what caused the sensory signals," Seth says.

The chosen emotion not only helps the brain make sense of these signals, but it also helps the brain predict better the immediate future and how to handle the situation at hand. Which emotion would be most useful? Which emotion will help me survive?

To figure that all out, Seth says, the brain uses one more piece of information and this part is key. The brain takes into account your past experiences, your memories.

Let's return back to that encounter with the grizzly bear. If your past experiences with bears come largely through news reports of attacks and maulings, then your brain will likely interpret your bodily sensations raised heart rate, raised blood pressure, sweaty palms as fear. Lots of fear! And this emotion will help drive you away from the bear. "So you can live another day," Seth says.

But what if your family hunts for a living? And your past encounters with a bear ended in a wonderful feast for you and your neighbors. Then your brain may interpret the adrenaline rush the heavy breathing and raised heart rate as excitement. This positive emotion will help drive you forward toward the bear, while all the physiological changes help you bring home dinner.

"Your brain uses memories from the past in order to create the present," says Barrett, who also does neuroscience research. "It's bringing knowledge from the past to make sense of the immediate future, which then becomes your present."

Neuroscientists call this "the predictive brain." Understanding how these predictions work is "very powerful knowledge," Barrett says. It means that emotions aren't hard-wired reactions to particular situations, which are out of your control (i.e., you see a bear and therefore you must feel afraid). But rather it's the opposite. "You can, in fact, modify what you feel in very direct ways," she says.

It's not about trying to force a happier or less fearful feeling in the moment, Barrett says. But rather, it's all about planning ahead. You can stack the deck in favor of your brain, choosing positive, uplifting emotions in two major ways, she says.

The first one is a no-brainer: You can take care of your body physically. According to this new theory, the brain constructs emotions based largely on physiological signals and other sensations from your body. So by boosting your physical health, you can decrease the chance your body will send unpleasant signals to your brain and, in turn, increase the chance, your brain will construct positive emotions instead of negative ones. "You can get more sleep. You can eat properly and exercise," she says.

The second approach to influencing your emotions may be less familiar but likely just as impactful: You can "cultivate" the emotions you want to have in the future.

"If you know that your brain uses your past in order to make sense [of] and create the present, then you can practice cultivating [positive] emotions today so that your brain can automatically use that knowledge when it's making emotions tomorrow," Barrett says.

By practicing particular emotions, you can "rewire" your brain, she says. "Your brain grows new connections that make it easier for you to automatically cultivate these emotions in the future." So when you start to feel a negative emotion, such as sadness or frustration, you can more easily swap that negative feeling for a positive one, such as awe or gratitude.

"For example, when I am video chatting with somebody in China, I can feel irritated very easily when the connection isn't very good," Barrett says. "Or I can feel awe at the fact that someone can be halfway around the world, and I can see their face and hear their voice, even if it is imperfect, and I can be grateful for that ability."

In this way, emotions are a bit like muscle memory. If you practice the finger patterns for a chord on the piano, a few minutes each day, eventually your fingers can play those chords with little thought. The chords become second nature.

The same goes for emotions. To help pull out of the pandemic blues, it's time to start "practicing" positive emotions and it won't take as much as learning all the chords.

All you need is about five to 10 minutes, says psychologist Belinda Campos at the University of California, Irvine. "Hopefully it wouldn't take people as much effort as it does to eat healthier or to exercise," she says. "Positive emotions feel good. I think people will find them rewarding enough to return to them and keep doing them."

Scientists say this practice is helpful to prevent or work with everyday doldrums and weariness. It isn't intended as a replacement for treatments, such as counseling and medication, for serious mood disorders or anyone going through intense or prolonged bouts of depression.

A few decades ago, scientists used to lump together all kinds of positive emotions into one concept: happiness. Since then, a group of psychologists, including Campos and Shiota, figured that there is a whole "family tree" of positive emotions, including pride, nurturant love, contentment, nostalgia, flow, gratitude and awe.

One reason these emotions often make us feel good is they shift our focus away from the self that is "me and my problems" and onto others, Campos says. "They help put the self in its balanced place, of not being absolutely the highest thing on the to-do list. They help us focus on the joys that relationships can bring."

She adds, "In this way, positive emotions are part of what helps you to put others before the self." And helping others often makes people feel good. "So, for example, people report levels of higher well-being when they're giving to others, and it can feel better to be on the giving end rather than the receiving end," she says. "I think that's more evidence that focusing on others can be really good for us."

The idea of cultivating positive emotions is pretty simple. Choose one of these emotions and then do a specific action regularly that helps evoke it. Psychologists have devised suggestions for how to get started, but it can be as simple as taking time to notice and appreciate the small things around you that uplift you. (Read three tips to get started at the end of this piece.)

Over time, your brain will start to use these emotions more often and turn to negative emotions less frequently.

Take, for instance, gratitude.

For the past year and a half, Dr. Sriram Shamasunder has been on the front lines of the COVID-19 pandemic. Shamasunder is a physician at the University of California, San Francisco, and he spends about half his time in low-income communities around the world.

To help bring more "light" into his life, Shamasunder started to keep a gratitude journal. It was part of a project for the Greater Good Science Center at the University of California, Berkeley.

Each day, Shamasunder simply jotted down things around him for which he was grateful. "So not necessarily spending a whole lot of time racking my mind, but just everyday occurrences that were powerful or meaningful or just simple and beautiful," Shamasunder told The Science of Happiness podcast. He jotted down the doctors and nurses working on Sunday, "the unseen hands who created a vaccine," "the evening light, magical and orange and blue," and a tree outside that provides refuge to birds, ants and squirrels.

By intentionally cultivating gratitude, for even a short period each day, Shamasunder found it easier to evoke positive feelings throughout the day. "The act of naming the gratitudes carried into the next day and the next, where I became more aware of things in my life that I should cherish in the moment, or I need to cherish."

Back in the fall, when Shiota, the Arizona State psychologist, felt her mind shrinking, she knew exactly which emotion she needed to cultivate.

She got up off the couch, drove West from her San Francisco home and ended up at the edge of the ocean. "I am trying to reconnect with the vast natural world, with the universe beyond my professional and personal responsibilities, and beyond this moment in time," Shiota writes in the Annals of the New York Academy of Sciences. "I am searching for awe."

Shiota is a world expert on awe. She says the emotion is difficult to define, "but I think that what we are dealing with is a change that happens in our mind and in our bodies and in our feelings when we encounter something so extraordinary that we can't explain it."

That encounter can be with something grand, such as a panoramic view of a red sun dipping into the Pacific Ocean. It can be with something minuscule, such as the black spots on a ladybug. (How did they get so perfectly round?) It can be a scent, a taste or sound. "It can be a very complex and powerful song that you've never heard before or even a scene in a TV show," Shiota says.

Whatever it is, the extraordinariness of the event makes you pause, for a bit, Shiota says, and try to figure it out. How does a rose smell like a lemon? Why does a perfectly ripened peach taste so good? "We simply slow down our body, slow down," Shiota says.

And this pause calms your body. "I've found evidence that the activation of our fight-flight sympathetic nervous system dials back a little bit."

The feeling of awe also widens your perspective, she says which Shiota desperately needed after spending so much time looking at screens. "I had to consciously force myself to look further away. I had to let my senses my sight, my sound, take in a broader scope of what was going on around me."

In addition to going to the beach, Shiota also simply walked around her neighborhood, looking for unexpected and inspiring things.

"There was this amazingly elaborate, chalk drawing in recognition of somebody's birthday. There was a couple, in which one person was clearly helping the other learn to roller-skate on the San Francisco hills. And they're clinging on to each other for dear life," she says with a chuckle. "Then the flowers! If you look closely at flowers, in a way that you never take the time to do, you'll see how incredibly intricate they are.

"So the opportunities for awe are there," she says. "Look for what moves you, what pushes your sense of boundaries of what is out there in the world."

It took a little time and patience Shiota says, but eventually these "awe walks" helped her recover from her pandemic funk. Practicing awe released her mind from that constraining "corset."

"Then my mind was able to spread out and take up the space that it needs to take to feel OK," she says. And once her mind released, her body followed. "When you take off the corset, your whole body goes, 'Oh, oh! That's much better.' "

Psychologists say you can improve your well-being if you recognize moments of positive feelings, value them and seek them out more often. Below, find a few other ideas for cultivating positive emotions and turning happiness into a habit. To explore more ideas, check out NPR's Joy Generator.

1) Share some appreciation: Campos recommends this simple practice. Get together with some friends and write out on cards three things that you're grateful for in the other person. Then share the cards with each other.

"We're using this task right now in my laboratory, and it seems to be very evocative of positive emotion," she says. And though the data is preliminary, she says, "what we see so far is that people enjoy writing what they appreciate in others, and they enjoy sharing it with the other person. It seems to be affirming bonds." Sometimes it even ends in hugs.

2) Take an awe walk: Take a five-minute walk outside each day where you intentionally shift your thoughts outward. Turn off your cellphone or even better don't bring it with you. "Focus your attention on small details of the world around you," psychologist Piercarlo Valdesolo at Claremont McKenna College suggests. Look for things that are unexpected, hard to explain and delightful.

For example, take a moment and find a crack in the sidewalk, where a weed is poking out, Barrett says. And let yourself feel awe at the power of nature. "Practice that feeling over and over again," she says. "Practice feeling awe at colorful clouds, an intricate pattern on a flower or the sight of a full moon."

3) Listen to a calm concert: A recent meta-analysis from the University of Michigan found that sounds of nature, including birdsongs and water sounds, lower stress, promote calmness and improve mood. Find a bench in your neighborhood under a tree or near water. Sit down, close your eyes and consciously listen to the natural sounds around you. Listen for birdsongs, rustling wind or trickling water. Try sitting for at least five minutes whenever you get a chance. Allow and enjoy calm to wash over you.

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There's A Simple Way To Feel Happier, According To The New Science Of Emotion : Shots - Health News - NPR

Cancer and the Heart; COVID and Dx Delays; Not the Same Old Accelerated Approval? – MedPage Today

The European Society of Cardiology has launched a clinical trial to evaluate cardiac MRI during chemotherapy to prevent treatment-related heart failure in patients with cancer.

A large retrospective study showed that patients with heart failure had a significantly increased risk of developing cancer. (ESC Heart Failure)

The American Heart Association awarded $11 million in grants to support research into disparities in cardio-oncology.

Patients with relapsed/refractory large B-cell lymphoma had significantly better event-free survival if they received the CAR T-cell therapy axicabtagene ciloleucel (Yescarta) instead of chemotherapy plus stem cell transplantation, Kite announced.

More evidence that the COVID-19 pandemic led to delays in cancer diagnosis and cancer-related surgery. (Journal of the National Cancer Institute)

Patients with multiple myeloma had highly variable responses to two doses of mRNA COVID-19 vaccination. (Cancer Cell)

"There is no reason why people cannot do randomized studies to get the drugs approved," said Richard Pazdur, MD, of the FDA's Oncology Center of Excellence, during an advisory committee meeting, possibly signaling a change of direction for the agency's accelerated approval process for cancer drugs. (Endpoints News)

A type of laser surgery for early-stage bladder cancer may help reduce surgical complications and the risk of recurrence. (Cedars-Sinai Medical Center)

Exelixis and Ipsen announced that the combination of cabozantinib (Cabometyx) and atezolizumab (Tecentriq) significantly improved progression-free survival as first-line treatment for advanced liver cancer.

A phase III trial of the chemokine receptor antagonist balixafortide plus eribulin for previously treated advanced HER2-negative breast cancer showed no improvement in the co-primary endpoint of objective response rate or the key secondary endpoint of clinical benefit rate versus eribulin alone, Polyphor announced.

Historically, prostate cancer responds poorly to immunotherapy, but a new study suggests a fourth of prostate cancers have molecular characteristics favorable for treatment with immune checkpoint inhibitors. (Clinical Cancer Research)

Assisted reproduction techniques did not increase subsequent risk of cancer in children and young adults. (European Society of Human Reproduction and Embryology)

Puma Biotechnology announced expanded FDA approval of neratinib (Nerlynx) to include both early-stage and metastatic HER2-positive breast cancer.

Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. He joined MedPage Today in 2007. Follow

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Limits for human embryo research have been changed : This calls for public debate – Down To Earth Magazine

The new regulation makes it possible to conduct research on human embryos that are at more advanced stages of development

For 40 years, research into early human development has been guided by the principle that after 14 days, an embryo should not be used for research and must be destroyed. This rule has been part of the law of more than 12 countries. But new guidelines released by the International Society for Stem Cell Research have removed this rule. This makes it possible to conduct research on human embryos that are at more advanced stages of development.

Now, countries must revise their laws, policies and guidelines to reflect this change. But first, public debate is crucial to determine the limits of what sort of research should be allowed.

Over the decades human embryo research has allowed us to understand normal and abnormal human development, as well as early genetic diseases and disorders. Studying human embryos, as the earliest forms of human life, can give us insight into why miscarriages occur, and how our complex body systems develop. Human embryos are also important for stem cell research, where researchers try and create cell-based therapies to treat human diseases.

Often, extra embryos are created during in-vitro fertilisation procedures. These extra embryos may be donated for research. They are cultured (or grown) in a laboratory and can be studied until they reach day 14 post-creation.

The 14-day rule has served as an international standard since 1990 when it was included in the Human Fertilisation and Embryology Act in the United Kingdom. At the time that it was introduced, it was not possible to keep human embryos alive in a laboratory for more than a few days. However, scientists have been recently been able to keep embryos alive for longer periods, between 12 and 13 days. The ethical, legal and social consequences of such research were also important considerations.

The 14-day rule and the new guidelines

Although the 14-day rule has been criticised as being arbitrarily decided, there are a number of reasons for the time frame.

After an egg cell is fertilised by a sperm cell, the resulting embryo consists of a few identical cells. Most embryos will implant in the uterus after the 14th day. After this point, the primitive streak appears, which is the first sign of an embryos developing nervous system. The rule also identified the point at which the embryo shows signs of individuation, because it is no longer possible for the embryo to split into twins after 14 days. Some people reason that due to these events, it is at this stage that a moral being comes into existence, and it would not be ethical to perform research on embryos after this time.

There has been increasing pressure from some researchers to remove the 14-day rule, or at least extend it, as it prevents critical research from being undertaken. Extending the rule would allow important research into early human development to be done. The new guidelines make it possible to do research on embryos older than 14 days if the approval processes of the relevant ethics committees are followed.

A significant problem, however, is that there is no longer any limit on the time frame for research. Would it be permissible to do research on human embryos that are 20 days old or 40 days old? The guidelines specify no limit. The longer a human embryo is allowed to grow, the more recognisably human it becomes. At what point would we regard the research unethical, and at what point does the moral cost outweigh the benefits of research?

What the law says

Countries around the world take a variety of approaches to human embryo research. Some like Italy and Germany dont allow it at all. Others, like the UK, allow research to continue until the embryo is 14 days old, after which it must be destroyed. There are also some which permit embryo research without identifying a limit. Some, like the United States, do not have any law regulating it (but there are guidelines which contain reference to the 14-day rule).

In South Africa, reference to the rule is found in the National Health Act (2003), which states that human embryo research may only be done with permission of the minister, and that the embryos must not be older than 14 days.

International guidelines are not legally binding. But the effect of the revised guidelines is that the international standard for best practice in scientific research has now changed. This means that countries which have implemented the rule in their laws will need to revise them so that they are in line with best practice in science.

The future of human embryo research

Human embryo research is a sensitive topic because people are divided on the moral status of the human embryo. Some people believe that the embryo, as the earliest form of human life, should be protected and not subjected to research at all. Others believe that while an embryo has some moral status, it cannot be protected in the same way as humans are, and may be used for some important research which could ultimately benefit people.

The decision to discard the 14-rule appears to have been made without public input. That does not encourage the public to trust in science, and public engagement should have come before such an an important rule was changed.

There are a number of approaches to working with the revised guidance. Bioethicist Franoise Baylis has suggested that project-specific time limits should be identified, based on the minimum amount of time required to address the stated research objectives. This would mean that some research would still be subject to the 14-day limit, while other studies would be permitted to exceed it. Another approach would be to keep the 14-day limit as the norm, and consider applications to exceed it case by case. Or the limit could be extended to 28 days.

The coming conversations surrounding embryo research will prove to be very important. The proverbial genie is out of the bottle, and public debate is crucial.

Sheetal Soni, Researcher, Lecturer, Attorney, University of KwaZulu-Natal

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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NPR’s Ina Jaffe Shared Her Breast Cancer Journey, Couple Moves Up Their Wedding After Cancer Diagnosis and More – Curetoday.com

NPR correspondent Ina Jaffe wrote about her journey with breast cancer.

Ina Jaffe, a correspondent for NPR, penned an essay about her journey with stage 4 metastatic breast cancer.

I've been keeping a secret. I've decided to tell it, she began.

Jaffe shared that she received her diagnosis two years ago and refrained from sharing it with friends or strangers because she was still in the hysterical stage.

Because, faced with an incurable cancer diagnosis, I did what any normal person would do: I stopped sleeping. I stopped eating. I sobbed a lot. I was grieving for my own life, she wrote.

Eventually, she told 50 of her closest friends and three editors at NPR who also kept the secret per her request. This past week, she decided to publicly share the news in hopes of helping others and expressing her outrage.

Up to 30% of women with early-stage breast cancer progress to stage 4, Jaffe said. I thought that you were more likely to get metastatic breast cancer if you'd been diagnosed with a more-advanced stage of breast cancer to begin with. Wrong again. It's not dependent on your stage at original diagnosis. I was stage 1B when I was first diagnosed in January 2012.

She also explained that she had a titanium rod implanted in her thigh to deal with a bone metastasis and brain radiation, among other treatments.

Carene and Cameron Hughes exchanged their vows on Sunday after moving up their wedding, which was originally scheduled for August. The couple had to push the wedding up because doctors found a tumor on Camerons pancreas, as well as two lesions on the liver. The cancer is stage 4.

I didnt want the memories of our wedding to be me rolling down the aisle in a wheelchair or something like that, I wanted it to be a memory she could have, and kids could have, even after Im gone, Cameron Hughes told WXII 12 News.

The Hughes and their four children still have hope that a clinical trial at Duke University could make a difference, but are taking the news one day at a time.

Dont take life for granted. You know, Im 51 and Ive lived a pretty good life. Theres things I want to see that I may not get to see, so live life, be happy, love, one love, Cameron Hughes said.

Children who are born through assisted reproductive technology (ART), such as in vitro fertilization, intracytoplasmic sperm injection and frozen embryo transfer, do not have an increased risk of cancer. The research was presented at the European Society of Human Reproduction and Embryology annual meeting this week.

The results are "quite reassuring, especially for children conceived by IVF, and are an important contribution to the current knowledge about health risks in ART-offspring," study author Dr. Mandy Spaan, of Amsterdam University Medical Center and the Netherlands Cancer Institute, told U.S. News.

The study may help doctors communicate better about any potential health risks for future children of patients who are considering fertility treatments. It will also provide gynecologists with "evidence-based information about the association between ART and cancer risk in children and adolescents," said Spaan in a news release.

Trey Mancini, a Baltimore Orioles player who missed the entirety of the 2020 season after a stage 3 colon cancer diagnosis, recently accepted an invitation from Major League Baseball to participate in the Home Run Derby.

This season was Mancinis return to baseball after undergoing treatment for the cancer. He is consistently among baseballs best in maximum exit velocity, according to ESPN.

Mancinis cancer was initially found just days after the spring training season had been shut down due to the COVID-19 pandemic. At 29, he never expected to receive the diagnosis his father, 58, had received a few years prior.

There were times early on when I wasnt entirely sure Id be playing baseball again, Mancini told MLB. I'd be lying if I'd say that was the first thing that came to mind. The whole time I just wanted to be healthy long-term and live a long life. And baseball definitely was on the back burner when I was going through all that.

For more news on cancer updates, research and education, dont forget tosubscribe to CUREs newsletters here.

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COVID Infection Unlikely to Jeopardize IVF Success, Small Study Suggests – MedPage Today

Women who were previously infected with COVID-19 did not have decreased chances of success with assisted reproduction treatment, according to a small observational study.

Among a cohort of 46 patients with prior SARS-CoV-2 infection, there were no significant differences in average anti-Mullerian hormone (AMH) levels before and after they got sick (1.73 vs 1.61 ng/ml, respectively), reported Maria Cruz Palomino, PhD, of the IVI Madrid fertility clinic.

For women with a normal ovarian reserve, AMH levels -- which indicate a woman's ovarian reserve status -- declined from 4.6 to 3.1 ng/ml. However, this decrease was unlikely to compromise a patient's ability to produce eggs for fertilization, said Palomino during her presentation at the European Society of Human Reproduction and Embryology annual meeting.

"Generally, the data showed no variation in AMH levels before and after SARS-CoV-2 infection," Palomino said in a press release. "We could assume that the chances of success in [patients'] fertility treatment remained intact."

Palomino added that while the researchers did observe a small drop in AMH levels among recovered COVID-19 patients with normal ovarian reserve, the decrease likely would not affect the chances of achieving pregnancy, and may not even be attributed to SARS-CoV-2 infection.

Albert Hsu, MD, an assistant professor of clinical ob/gyn at the University of Missouri in Columbia, who was not involved in this study, said that while these findings provide some information about SARS-CoV-2 and fertility, more data are needed before stating that COVID-19 infection does not impact chances of IVF success. Additionally, Hsu stated that AMH levels, which the study authors used to indicate ovarian reserve status, may not actually convey how likely it is for in vitro fertilization (IVF) patients to conceive.

"Anti-Mullerian hormone is a great predictor of how many eggs I am going to get when I stimulate a woman with IVF," Hsu told MedPage Today. "It very much does not predict pregnancy."

Because SARS-CoV-2 binds to the ACE-2 receptor, which is widely expressed in the ovaries, some have raised concerns about how COVID-19 infection might affect ovarian reserve, Palomino's group stated. However, initial studies have shown no correlation between COVID-19 and loss of fertility in reproductive-age women.

In this study, Palomino and colleagues recruited patients from 11 clinics in Spain who had IVF between May and June of 2020. All 46 study participants had documented baseline hormone levels before receiving a positive test for COVID-19.

Researchers analyzed AMH levels as an indicator of their response to fertility treatment. Around 16 participants had a low ovarian reserve (AMH <1 ng/ml), and 30 had normal ovarian reserve status (AMH 1 ng/ml). The average age for patients with low and normal ovarian reserve was 39 and 35, respectively.

AMH levels remained stagnant in women with low ovarian reserve, from 0.8 ng/ml before infection to 0.7 ng/ml afterward.

Palomino and colleagues emphasized that this was a small study, and is not robust enough to inform public health recommendations. Additionally, because this is an observational study, results are limited by potential confounding.

Amanda D'Ambrosio is a reporter on MedPage Todays enterprise & investigative team. She covers obstetrics-gynecology and other clinical news, and writes features about the U.S. healthcare system. Follow

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Spatial Genomics & Transcriptomics Market Analysis by Size, Trends, Share, Key Country, Opportunities, Growth, Emerging Technologies, And Regional…

Technological advancements in sequencing technologies, increasing application of spatial genomics and transcriptomics in biomarker identification and drug discovery, and increasing funding to expand R&D activities are key factors driving revenue growth of market

Market Size USD 178.4 Million in 2020, Market Growth at a CAGR of 18.1%, Market Trends Increasing prevalence of genetic disorders globally

The Global Spatial Genomics & Transcriptomics Market size is expected to reach USD 675.34 Million by 2028 at a CAGR of 18.1% over the forecast period, according to the latest report by Reports and Data. Key factors driving market revenue growth include increasing prevalence of genetic disorders and chronic conditions such as cancers, neurological disorders, and rare diseases, which have boosted need for high-resolution multiplex assays and instruments, and this is expected to further drive developments in spatial-based technologies. Increasing application of spatial genomics and transcriptomics for drug discovery and biomarker identification is also a key factor expected to drive revenue growth of market over the forecast period. Significant funding to expand R&D activities in the field of spatial-based technology is expected to support market growth going ahead.

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Spatial transcriptomics covers methods specifically designed to assign cell types to their specific locations across tissue samples. It allows determination of subcellular localization of mRNA molecules. Data obtained about spatial distribution of mRNA molecules allows researchers to study cellular heterogeneity in tissues, tumors, and immune cells. Spatial-profiling based solutions allows analysis of tissue microenvironment, tumor biology, and tissues biomarkers. Spatial genomics and transcriptomics offers key insights in the fields of oncology, immunology, cell and gene therapy, histology, and embryology.

Spatial genomics and transcriptomics are novel research fields that aim to fill the knowledge gap about cellular machinery, spatial organization, differentiations, and localization that occurs at genomic and transcriptomics level within each cell and in tissues. These techniques have significant potential in managing chronic and rare diseases and rising burden of chronic disease such as cancers and diabetes across the globe have boosted their application in drug discovery and development. This is expected to fuel revenue growth of market over the forecast period. However, lack of skilled professionals and low awareness about advanced spatial-based technologies can restrain market growth to a significant extent over the forecast period.

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For the purpose of this report, Reports and Data has segmented the global spatial genomics & transcriptomics market based on technique, product application, end-use industry, and region:

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IU researchers developing noninvasive brain stimulation technique to treat neurological disorders – News-Medical.Net

Indiana University School of Medicine researchers are developing a new, noninvasive brain stimulation technique to treat neurological disorders, including pain, traumatic brain injury (TBI), epilepsy, Parkinson's disease, Alzheimer's disease and more.

Given the increasing use of brain stimulation in human brain study and treatment of neurological diseases, this research can make a big impact on physicians and their patients."

Xiaoming Jin, PhD, associate professor of anatomy, cell biology and physiology

When someone experiences a brain injury, nerve injury, or neurodegeneration, such as in epilepsy and TBI, there is damage to the brain which can lead to loss and damage of nerve or neurons and development of hyperexcitability that underlies some neurological disorders such as neuropathic pain and epilepsy.

"The conventional treatment is mainly to try to directly inhibit such hyperexcitability," Jin said, "but we found the initial damage of the brain or nerve system was caused by a loss of brain tissue, which causes the nervous system to compensate for loss of function by working harder, so we need to stimulate activity instead of inhibit it."

The technique, described in a newly published paper in Neurotherapeutics, uses a new type of magnetoelectric nanoparticles that can be delivered to a specific part of the brain using a magnetic field. After, a magnetic wave can be emitted to stimulate neural activity in that particular part of the brain. The method is noninvasive, good for stimulating deep brain function and is more efficient than traditional methods of brain stimulation, without the need for genetic manipulation.

"This is the only new type of nanoparticle that allows us to effectively stimulate the brain without doing any invasive procedures," Jin said. "We can inject the nanoparticle as a solution into the vein and then bring it to any part of the body. When you apply a magnet on the head, you can localize and deliver the nanoparticle to the targeted brain region."

The team has been working on the technique for five years in collaboration with the University of Miami and hopes to begin studying the method in humans in the next couple of years. The study has received funding from the Defense Advanced Research Projects Agency (DARPA) of the United States Department of Defense, National Science Foundation, as well as the Indiana Clinical and Translational Sciences Institute (CTSI), which helped provide funding for a medical neuroscience graduate student, Tyler Nguyen, to participate in the research. Read the full published paper in Neurotherapeutics.

Source:

Journal reference:

Nguyen, T., et al. (2021) In Vivo Wireless Brain Stimulation via Non-invasive and Targeted Delivery of Magnetoelectric Nanoparticles. Neurotherapeutics. doi.org/10.1007/s13311-021-01071-0.

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IU researchers developing noninvasive brain stimulation technique to treat neurological disorders - News-Medical.Net