Cerebral and systemic physiological effects of wearing face masks in young adults – pnas.org

Abstract

The COVID-19 pandemic led to widespread mandates requiring the wearing of face masks, which led to debates on their benefits and possible adverse effects. To that end, the physiological effects at the systemic and at the brain level are of interest. We have investigated the effect of commonly available face masks (FFP2 and surgical) on cerebral hemodynamics and oxygenation, particularly microvascular cerebral blood flow (CBF) and blood/tissue oxygen saturation (StO2), measured by transcranial hybrid near-infrared spectroscopies and on systemic physiology in 13 healthy adults (ages: 23 to 33 y). The results indicate small but significant changes in cerebral hemodynamics while wearing a mask. However, these changes are comparable to those of daily life activities. This platform and the protocol provides the basis for large or targeted studies of the effects of mask wearing in different populations and while performing critical tasks.

Many governments have mandated the wearing of face masks in response to the coronavirus disease 2019 (COVID-19) pandemic in order to mitigate the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. The effectiveness of this measure is currently being evaluated (1). This has led to ongoing discussions about possible adverse effects of mask wearing (e.g., dizziness, headaches, fainting), especially within the elderly, during long-term continuous mask usage and during physical activity. Chan et al. (2) reported that the arterial oxygenation (SpO2) did not change in elderly subjects after 1 h, while Law et al. (3) reported a significant effect on baseline cerebral hemodynamics and end-tidal carbon dioxide pressure (EtCO2) using functional MRI (fMRI) on middle-aged adults. No task-induced hemodynamic changes were found in this study. The bulk of these concerns arise due to potential hypercapnic effects of carbon dioxide rebreathing, which has not yet been evaluated in a thorough manner. Also, the brain function was evaluated only at the level of a surrogate of oxygen consumption. Noninvasive functional near-infrared spectroscopy (fNIRS) and functional diffuse correlation spectroscopy (fDCS) use near-infrared light to measure microvascular cerebral hemodynamics without the constraints of the fMRI scanners. When combined together, they allow us to relate cerebral blood/tissue oxygen saturation and blood flow to the cerebral oxygen metabolism. Their main disadvantage is the potential signal contamination due to the extracerebral tissues and the limited penetration depth. Nevertheless, the advantage of studying mask effects on brain function in realistic settings merits their uses for a thorough study to look at the physiology in a holistic manner.

To this end, we have investigated the effect of mask wearing (FFP2 [European Union standard, similar to N95 in North America and KN95 in China] versus surgical) on cerebral hemodynamics, blood/tissue oxygenation, and oxygen metabolism as well as the systemic physiology with a multimodal platform of custom near-infrared spectroscopies and commercial physiological monitors in healthy young adults.

Thirteen volunteers (median age: 27.0 y [23 to 33 y], six females) took part in the study. Fig. 1 summarizes the findings. Small but significant changes in cerebral blood flow (CBF) and cerebral blood oxygen saturation (StO2) were detected for both mask types: 1) CBF increased by 6.5% (95% CI: 2.6, 10.5%) for the FFP2 mask and 6.2% (95% CI: 2.4, 9.9%) for the surgical mask; 2) StO2 increased by 0.9% (95% CI: 0.2, 1.7%) for the FFP2 mask and also 0.9% (95% CI: 0.1, 1.6%) for the surgical mask; 3) total hemoglobin concentration (tHb) increased significantly only for the FFP2 mask by 0.9 M (95% CI: 0.3, 1.5 M). Changes in oxygen extraction fraction (OEF) and cerebral metabolism (CMRO2) (defined in SI Appendix) were not statistically significant: 1) OEF decreased by 1.7% (85% CI: 4.1, 0.8) for the FFP2 mask and by 2.4% (95% CI: 4.7, 0.0) for the surgical mask; 2) CMRO2 increased by 4.5% (95% CI: 1.3, 10.4%) for the FFP2 mask and by 3.6% (95% CI: 1.7, 9.0%) for the surgical mask. None of these changes were statistically significantly different between the two mask types.

(Left) Changes in the different parameters are shown for FFP2 masks (red) and surgical masks (blue). denotes a difference and r is a ratio. The arrow indicates a significant change (P < 0.05) whose direction is an increase or a decrease. Additionally, for cerebral hemodynamics, we have reported (green) changes during typical tasks such as basic cognitive, visual, or motor tasks (4, 8) for comparison. (Right) Time series of the population mean of all parameters are shown for both mask types (same color code). Time 0 is the time when the mask was placed and the shaded area indicates the time taken for placing the mask, which was excluded from the analysis. Data to the Right of the 3-min mark (magenta) were used for analysis to allow the physiology to stabilize after placing the mask. The data were normalized to 300 s prior to the mask placement.

EtCO2 showed a significant change but was discarded since the probe was affected by the air trapped within the mask. Transcutaneous carbon dioxide partial pressure (TcCO2) and SpO2 did not significantly change due to wearing a mask, while mean arterial pressure (MAP) and heart rate (HR) increased significantly for the surgical mask by 4.1 mmHg (95% CI: 0.5, 7.6 mmHg) and 2.0 beats/min (95% CI: 1.0, 3.1 beats/min), respectively. Respiratory rate (RR) decreased significantly for the FFP2 mask by 3.2 breaths/min (95% CI: 5.4, 1.1 breaths/min). A significant difference in HR between mask types of 1.2 beats/min (95% CI: 0.0, 2.4 beats/min) was detected.

Our findings show that wearing a face mask leads to statistically significant changes in the cerebral hemodynamics and oxygenation (CBF and StO2) in healthy young subjects at rest, even for this first relatively short period of mask usage. However, the changes observed are minimal and are comparable to those typically observed during daily life (4). Within the limitations of the study, we cannot claim any concerns for mask use during daily life activities for healthy, young individuals. In order to draw a stronger conclusion, the duration of mask wearing could have been longer (harder to disentangle its effects from other physiological variables such as fatigue), the study population should be more heterogeneous representing the society in general, and the sample sizes can be increased. Another limitation is the fact that the order of the masks was fixed, therefore one should be critical about the results regarding differences in the mask types and additional differences may be revealed in the future. The noticeable differences in variance of the time traces are related to the intersubject variability, which may be related to the fit of the mask, mask types, and the individuals physiology.

Furthermore, we did not observe significant changes in TcCO2 and SpO2. The increase in MAP and HR for the surgical mask may have been caused by the discomfort of probes, placement of masks, and the order of studies. Here, we did not account for these stressors as potential confounding effects, since they are also part of daily life. This observation is further strengthened since TcCO2 did not change, i.e., the hypothesized hypercapnic effect was not observed. We stress that in the literature mainly EtCO2 is utilized as a surrogate of blood carbon dioxide levels, which, however, is influenced by the trapped carbon dioxide under the mask with standard equipment (5). TcCO2 provides insights as a better surrogate for the partial pressure of carbon dioxide.

Overall, our study provides a holistic view of understanding the potential effects of mask wearing in healthy, young adults by a thorough characterization of both the systemic physiology, the presumed driving biomarker of carbon dioxide rebreathing effect, and cerebral hemodynamics. The large intersubject variability while wearing a mask suggests that individuals may have differing responses and the platform/protocol that we introduce here could be utilized on elderly subjects or those with preexisting respiratory or cerebrovascular problems. These populations may behave differently. Finally, the potential effect of mask wearing on individuals performing critical tasks needs to be studied with future investigations. Investigations of these effects are important for policy making in order to maintain quality of life for individuals and for minimizing risks in persons carrying out critical tasks.

The study protocol was approved by the ethical committee of Hospital Clinic Barcelona and all participants signed informed consent. Young healthy adults (range for inclusion: 20 to 35 y of age) were recruited. Participants sat in a chair and read a scientific text during the experiments. The experimental paradigm involved two 10-min periods: 1) without wearing a mask and 2) with a mask. A commonly used three-layer surgical mask and a FFP2 mask (RM101 FFP2 NR, Zhejiang Yinghua Technology Co. Ltd.) were tested. Cerebral blood flow, oxygenation, and oxygen metabolism were measured bilaterally over the prefrontal cortex using transcranial diffuse correlation spectroscopy (DCS) and time-resolved near-infrared spectroscopy (TR-NIRS) (6). Changes in CBF, StO2, and tHb were determined. MAP, HR, SpO2, RR, EtCO2, and TcCO2 were monitored. Signal processing was performed with Matlab (R2019a, MathWorks) and statistical analysis (R, v4.0.3) was applied to determine whether mask wearing was leading to a significant change in the signals. Raw DCS and TR-NIRS data were fitted using the analytical solution. Artifacts were manually removed, the data were smoothed (30-s window), and the changes were averaged over both hemispheres since no difference between them was detected (P >> 0.5, paired Wilcoxon test). For further details see SI Appendix.

This work was funded by la Fundaci La Marat de TV3 (201709.31, 201724.31); Fundaci CELLEX Barcelona; Agencia Estatal de Investigacin (PHOTOMETABO, PID2019-106481RB-C31, PRE2018-085082); the Severo Ochoa (CEX2019-000910-S); laCaixa (LlumMedBcn); Instituci Centres de Recerca de Catalunya (CERCA), Agncia de Gesti d'Ajuts Universitaris i de Recerca (AGAUR)-Generalitat (2017SGR1380); RIS3CAT (CECH, 001-P-001682); LASERLAB-EUROPE V and EU Horizon 2020 (BitMap 675332, VASCOVID 101016087, LUCA 688303, TinyBrains 101017113).

Author contributions: J.B.F., L.K.F., F.S., R.D.-M., M.M., and T.D. designed research; J.B.F. and L.K.F. performed research; J.B.F. and L.K.F. analyzed data; J.B.F., F.S., and T.D. wrote the paper; J.B.F., L.K.F., F.S., R.D.-M., M.M., and T.D. interpreted data; F.S., M.M., and T.D. provided supervision; and R.D.-M. and T.D. provided administrative, technical, and material support.

Competing interest statement: T.D. and J.B.F. are inventors on relevant patents. Institut de Cincies Fotniques (ICFO) has equity ownership in the spin-off company HemoPhotonics S.L. Potential financial conflicts of interest and objectivity of research have been monitored by ICFOs Knowledge and Technology Transfer Department.

This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.2109111118/-/DCSupplemental.

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Cerebral and systemic physiological effects of wearing face masks in young adults - pnas.org

2021 Nobel Prize in Physiology or Medicine goes to two researchers for their discovery of receptors for temperature and touch – Chemical &…

2021 Nobel Prize in Physiology or Medicine goes to two researchers for their discovery of receptors for temperature and touch  Chemical & Engineering News

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2021 Nobel Prize in Physiology or Medicine goes to two researchers for their discovery of receptors for temperature and touch - Chemical &...

2 US scientists win Nobel Prize in medicine for showing how we react to heat, touch – Fox17

Two American scientists have won the Nobel Prize in physiology or medicine for their discovery of receptors for temperature and touch.

The Nobel Assembly at Karolinska Institutet announced Monday morning that its awarding the honor to David Julius and Ardem Patapoutian.

Peter Barreras/Peter Barreras/Invision/AP

The Nobel Prize organization says Julius and Patapoutian solved how nerve impulses are initiated so that temperate and pressure can be perceived.

Julius utilized capsaicin, a pungent compound from chili peppers that induces a burning sensation, to identify a sensor in the nerve endings of the skin that responds to heat, according to the organization.

And Patapoutian reportedly used pressure-sensitive cells to discover a novel class of sensors that respond to mechanical stimuli in the skin and internal organs.

These discoveries launched research activities that officials say led to a rapid increase in our understanding of how the human nervous system senses heat, cold, and mechanical stimuli.

The laureates identified critical missing links in our understanding of the complex interplay between our senses and the environment, said the organization.

Julius, 65, is a physiologist who works as a professor at the University of California, San Francisco, while Patapoutian is a molecular biologist and neuroscientist at Scripps Research in La Jolla, California.

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2 US scientists win Nobel Prize in medicine for showing how we react to heat, touch - Fox17

Why are males still the default subjects in medical research? – The Conversation AU

Women and girls account for 50% of the population, yet most health and physiology research is conducted in males.

This is especially true for fundamental research (which builds knowledge but doesnt have an application yet) and pre-clinical (animal) research. These types of research often only focus on male humans, animals and even cells.

In our discipline of exercise physiology, 6% of research studies include female-only participant groups.

So why do so many scientists seem oblivious to the existence of half of the worlds population?

Read more: Equal but not the same: a male bias reigns in medical research

Firstly, its important to understand key terminology in society and research. As referred to throughout this article, male and female are categories of sex, defined by a set of biological attributes associated with physical and physiological characteristics.

In comparison, men, women and non-binary people are categories of gender: a societal construct that encompasses behaviours, power relationships, roles and identities.

Here we discuss research on specific sexes, but further consideration of gender-diverse groups, such as transgender people, also remains a gap in science.

The main reasoning is that females are a more complicated model organism than males.

The physiological changes associated with the menstrual cycle add a whole lot of complexities when it comes to understanding how the body may respond to an external stimulus, such as taking a drug or performing a specific type of exercise.

Read more: From energy levels to metabolism: understanding your menstrual cycle can be key to achieving exercise goals

Some females use contraception, and those who do use different types. This adds to the variability between them.

Females also undergo menopause around the age of 50, another physiological change that fundamentally impacts the way the body functions and adapts.

Even when research with females is performed properly, the findings may not apply to all females. This includes whether a female individual is cisgender or gender nonconforming.

Altogether, this makes female research more time-consuming and expensive and research is nearly always limited by time and money.

Yes, because males and females are physiologically different.

This does not only involve visually obvious differences (the so-called primary sex characteristics, such as body shape or genitals), but also a whole range of hidden differences in hormones and genetics.

Theres also emerging evidence from our research team that sex differences impact epigenetics: how your behaviours and environment affect the expression of your genes.

Conducting health and physiology research in males exclusively disregards these differences. So our knowledge of the human body, which is mostly inferred from what is observed in males, may not always hold true for females.

Some diseases, such as cardiovascular (heart) disease, present differently in males and females.

Read more: Women who have heart attacks receive poorer care than men

Males and females may also metabolise drugs in a different way, meaning they may need different quantities or formulations. These drugs can have sex-specific side effects.

This may have major consequences in the way we treat diseases or the preferred drugs we use in the clinic.

Take COVID-19, for example. The severity and death rates of COVID-19 are higher in males than females. Sex differences in immunity and hormonal pathways may explain this, therefore researchers are advocating for sex-specific research to aid viral treatment.

No matter the cost or added complexity, research should be for everyone and apply to everyone. International medical research bodies are now starting to acknowledge this.

A March 2021 statement from the Endocrine Society, the international body for doctors and researchers who study hormones and treat associated problems, recognises:

Before mechanisms behind sex differences in physiology and disease can be elucidated, a fundamental understanding of sex differences that exist at baseline, is needed.

The National Institutes of Health (NIH), the largest medical research board in the United States, recently called for researchers to account for sex as a biological variable.

Unless a strong case can be made to study only one sex, studying both sexes is now a requirement to receive NIH research funding.

The Australian equivalent, the National Health and Medical Research Council (NHMRC), indirectly recommends the collection and analysis of sex-specific data in animals and humans.

However the inclusion of both sexes is not yet a requirement to receive funding in Australia.

Because sex matters, we created a freely available infographic based on our research that aims at making female health and physiology research easier to design.

It presents as a simple flow through diagram that researchers can use before starting their project and prompts them to consider questions such as:

is the phenomenon I am investigating influenced by female hormones?

should all females in my cohort use the same contraception?

on which day of the menstrual cycle should I test my participants for the most reliable result?

Depending on the answers, our infographic proposes strategies (that can be practical such as who to recruit and when or statistical) to design research that takes into account the complexity of the female body.

Its easy to follow and accessible to all. And, while initially designed for exercise physiology research, it can be applied to any type of female health and physiology research.

Read more: Medicine's gender revolution: how women stopped being treated as 'small men'

Based on our infographics, we designed a female-only, four-year research project to map the process of muscle ageing in females. Females live longer than males but, paradoxically, are more susceptible to some of the consequences of ageing. Despite lots of ageing research in males, we still know very little about the female-specific characteristics at play.

So yes, the future is female so is our research. And we hope to inspire health and physiology researchers all over the world to do the same.

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Why are males still the default subjects in medical research? - The Conversation AU

Environment and Human Behavior | Applied Social Psychology …

What is the relationship between the environment and human behavior? Environmental psychologists study this question in particular, by seeking to understand how the physical environment affects our behavior and well-being, and how our behavior affects the environment (Schneider, Gruman, and Coutts, 2012).For example, pollution, a component of the physical environment, absolutely can affect our well-being and health. Ozone pollution can have unfavorableeffects on humans including shortness of breath, coughing, damage to the airways, damaging the lungs, and making lungs more susceptible to infection (U.S. Environmental Protection Agency [EPA], 2016). Meanwhile, us taking the action to recycle affects the quality of our environment. Recycling and using recycled products saves a substantial amount of energy considering it takes less energy to recycle products, than it would to create new materials entirely. In turn, the action of recycling helps battle climate change, one of the biggest threats our planet faces.

If humans can have direct effects on the environment, are we responsible for climate change? A lot of hard evidence suggests, yes. Every once in awhile, our planet warms from natural causes. This can occur from events like volcanic activity, or a change in solar output. However, recent evidence shows climate change is occurring too drastically to be solely explained through natural means. Humans have made remarkable advancements in technology by creating more automobiles, machines, factories, etc. But this revolution is not all positive. We have seen a rapid increase in greenhouse gas emissions over the last century. Sources of greenhouse gasses include automobiles, planes, factory farming and agriculture, electricity, and industrial production. The issue with greenhouse gasses is that they absorb and emit heat. Abundant greenhouse gases in our atmosphere include carbon dioxide, methane, nitrous oxide, and fluorinated gases (EPA, 2017). When thereare large quantities of greenhouse gasses in the atmosphere, the planet is going to get gradually warmer.

What happens as a result of climate change? Believe it or not, we are already experiencing some very damaging effects of climate change. Heat waves, floods, droughts, wildfires, and loss of sea ice just to name a few (National Aeronautics and Space Administration [NASA], 2017). Scientists predict we will begin to experience even more harmful effects of climate change in the future. At the current rate we are going, the Arctic sea ice is expected to disappear entirely by the end of the century. The current effects we are seeing are also expected to intensify. An even greater problem is the fact that plants and animals are unable to adapt to the quickly changing environment, and are dying off. As a result of climate change, animals habitats are becoming completely inhabitable. We are seeing a rapid loss of species which will inevitably effect the natural flow of the biosphere and the individual ecosystems it is composed of.

What can we do to slow down the effects of climate change? The first, and most simple response is we need to recognize climate change is a real threat to our planet, and even our existence. Given the recent political shift that has occurred in the United States, climate change and environmental issues do not appear to be a prime concern to some individuals. The blunt truth is we do not have time to wait. Climate change has already startedto take its toll on the planet, and ignoring it is no help to anyone. As I stated above, human behavior has the potential to make dramatic changes to the environment. Practicing beneficial behaviors such as engaging in environmental activism, recycling, conserving energy, decreasing water use, and decreasing the frequency of automobile use,are all useful measures to take regarding this issue. You can also research ways to reduce your carbon footprint. As a vegan, I always advise people to cut down on meat, dairy, and egg consumption given the large toll agriculture takes on water loss and the environment in general.If we collectively work to battle this giant threat to our environment, we may be able to slow, and even reverse the effects of climate change.

References

National Aeronautics and Space Administration (NASA)., (2017, January 31). Consequences of Climate Change. Retrieved February 2, 2017, from http://www.nasa.gov

Schneider, F. W., Gruman, J. A., & Coutts, L. M. (2012). Applied social psychology: understanding and addressing social and practical problems. Los Angeles: Sage.

U.S. Environmental Protection Agency (EPA)., (2016, March 4).Health Effects of Ozone Pollution. Retrieved February 2, 2017, from http://www.epa.gov

U.S. Environmental Protection Agency (EPA)., (2017, January 20). Overview of Greenhouse Gases. Retrieved February 2, 2017, from http://www.epa.gov

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Are humans obsessed with status? Will Storrs The Status Game makes the case. – Vox.com

Are you obsessed with status?

Id love to tell you that I dont care about status, but thats a lie. I do care about it, even though I know I shouldnt. When I publish an article or a podcast or when I drop a half-clever tweet, I still find myself waiting for the little ping on my phone. I still get disappointed when something doesnt land the way I hoped. And its ridiculous. None of it matters.

I just read a book about all this, and I cant stop thinking about it. Its called The Status Game, and the author is Will Storr, a journalist and writer from the UK. His thesis is that everyones playing a status game, sometimes multiple status games, and if youre not aware of that, you may not understand why you do what you do or why you dont do what you wish you would.

I reached out to him for this weeks episode of Vox Conversations to talk about the evolution of status in human life and all the ways it distorts and defines our behavior, as individuals and societies. It challenged the way I think about the role of status in my own life and in some ways it made me feel less terrible about some of my unhealthy fixations. If you find yourself needlessly worried about status, it might do the same for you.

Below is an edited excerpt from our conversation. As always, theres much more in the full podcast, so subscribe to Vox Conversations on Apple Podcasts, Google Podcasts, Spotify, Stitcher, or wherever you listen to podcasts.

You have a pretty provocative claim in the book. You offer a definition of tyranny as something that happens when status games go bad or wrong. You write that, We must accept that tyranny isnt a left thing or a right thing. Its a human thing. It doesnt arrive goose-stepping down the streets. It seduces us with stories.

I used to study ideologies and how they transformed into political religions. The question that always vexed me, particularly about a case like Nazi Germany, is how does one of the most sophisticated, developed, and well-educated societies on the planet become so deranged?

Your answer seems to be that they were playing a status game that went disastrously wrong. Thats not to obviate or diminish the role of ideology or racism or whatever. Those are all real, and they matter. But its also true that our beliefs are often props for much deeper psychological drives. However insane Nazi Germany appeared from the outside, and it was indeed insane, for lots of people inside, they were just jockeying for position within a social hierarchy. That has a way of blinding our moral intuitions in really disturbing ways.

So this was one of the big revelations for me, really. Being brought up in the UK, we were obsessively taught about the Nazis and the Second World War. Its very recent in our shared history. But the question, exactly as you put it, is how can this incredibly sophisticated nation fall so hard and so badly? The answer that I came to in The Status Game was that actually, the sophistication of that nation is part of the reason why it fell so badly.

Earlier in the book, I talk about individual killers, whether its terrorists or incel spree killers or serial killers like Ed Kemper. Men are much more likely for evolutionary reasons to restore what they perceive as their lost status with violence. They were all humiliated. All of those men were serially humiliated throughout their childhoods, and suffered from the perception that they were extremely low-status. It wasnt just one event. They were dragged through it in quite barbaric ways.

But also, and I think essentially, they all started off very high. All of those people were narcissistic. I cant say that they were narcissists in the clinical sense, because Im not qualified to say that. In the book, I use the word grandiose. I argue that this is a really deadly combination. If you take a narcissistic man and chronically humiliate them, theres a likelihood that theyre going to become violent.

I talk in detail about this guy, Elliot Rodger, the incel guy. [He was] completely grandiose and entitled and unpleasant in his worldview, found it impossible to make friends and girlfriends as he became an adolescent, and became obsessed with the fact that girls didnt like him and with all the misogyny that that suggests. He ends up, at the age of 17, having this kind of crazy ideology which basically said that sex should be abolished, because he said the reason the world is terrible, its all the fault of women. Because women always choose the jocks, the violent, aggressive jocks to procreate with, so they have all these jock, violent babies.

So its all the fault of women. So what we need to do is exterminate the women, apart from a few which will be artificially inseminated in laboratories, to keep the human race going. Then that will be a kind of utopia. You read that, and you just think, My god, this guy is sick. That is a sick ideology. Surely, this guy is mad. Hes crazy. Certainly, his actions he did a spree killing in Santa Barbara [County] would suggest that that would be true.

But then you look at what happened in Germany in the 1930s, and you see almost exactly that happening, but on the level of the nation. Germany pre-World War I was a pretty grandiose nation, and for lots of good reasons. They were the most successful nation in Continental Europe, probably all of Europe, including the UK at that point. Then, famously after the First World War, they felt completely humiliated. Not only were they taken out of the war when they felt that they were going to win, the Treaty of Versailles was designed to humiliate them, and they were dragged down into a state of absolute national distress and humiliation.

Mainstream historians agree that the main thing the Germans wanted was the restoration of what they saw as Germanys rightful place at the top. Anti-Semitism was widespread in Europe. It was a major issue, but the main thing they were focused on was the restoration of what they saw as Germanys place at the top of the status game.

What Hitler did, and what all the anti-Semites did, was do exactly what Elliot Rodger did. They weaved this terrible story, which in its outlines is no different to the story that Elliot Rodger told about women. Its just that they were about the Jewish people, with the result being the Holocaust. Suddenly, when you look at what happened through the lens of status, it suddenly becomes explicable. You see these patterns of behavior in individuals. You also see them in nations.

You have a chapter in the book where you call the humiliated male the games most lethal player. You quote a proverb that I had never encountered before that goes, The child who is not embraced by the village will burn it down to feel its warmth.

I swear, man, that quote is still kind of washing over me.

Its incredible, isnt it?

It really is, and it just kind of distills all of this.

Men are really violent compared to women, and there are of course differences. On the killing, its very much tied to humiliation, the humiliation of the family. In some cultures, women are very implicated in honor killings. So, Im not weaving my own simplistic story of men bad, women good. Thats not true at all. Women have got their dominance techniques ostracization, bullying, group attacks on other people the kind we see on social media, for example. Its not accurate to say thats toxic femininity or anything like that. Men and women do that, but theres no shortage of women using that form of aggression, that kind of way of achieving status through dominance.

You say that the experience of humiliation is essentially the annihilation of the self. And you can look at extreme, disgusting cases like Rodger, and be tempted into thinking that the rest of us are exempt from that, but that is a kind of self-deception. These impulses live in all of us, and to forget that is to be vulnerable to the worst manifestations of it.

I forget the precise numbers, but in that chapter, I talk about a major study that talked about men and women, about the last time they fantasized about killing somebody. For both genders, a large chunk of that was about status. It was about being humiliated. It triggers these homicidal fantasies in a large number of people, across the genders.

So, yeah, Im sure we can all admit in ourselves that some of the times weve behaved, weve been at our worst, not only the most in pain, because humiliation is acutely painful. Because status is so important to us, when its removed from us in such a complete way, its extremely painful.

But then some of the times when weve acted out, and weve been at our worst, are the times when we have felt humiliated. For me personally, I know that when I become most irrational in my head is when Im dividing the world into heroes and villains, and telling this nasty moral story about goodies and baddies. It tends to be when Im feeling my status is under threat by people or groups.

I want to go back to something you said earlier about social media. Is the internet and social media the greatest or the most powerful status-generating machine in all of human history?

Religion is a status-generating machine. The nation is a status-generating machine. So its quite difficult to judge them in that sense, but certainly thats what social media is. In the book, I talk about the first social media site as we know it, which was called The Well. It was back in the mid-80s, back in the time when we were still putting our phones on modems and dialing in and all that stuff. Even then, it was extraordinary to look at the history The Well.

It was a bit like Reddit. It was just people, most of them on the West Coast of the US with things in common, who would gather in groups and discuss them. If you were into wine, youd talk about wine. Im sure there was lots of showing off and stuff about what you knew about wine.

Then, when it got to about 500, this person arrived who I describe as the worlds first internet troll, and he basically just started attacking everyone. He really hated men, and he let them know it, and he called them all racists and perverts and destroyers. He completely maddened them. They just canceled this person. They mobbed up against him, kicked him out, deleted lots of his entries. ... He was somebody that was sort of non-gendered but [used] male pronouns.

They were having all these arguments about pronouns that were still having today. They were making those stupid jokes about If you identify as you want, then I want to identify as the King Poobah. Its everything that happens on social media today, and it was happening on the first website back in the 80s, where the population was around 500.

So Facebook and Twitter havent helped, but theyre not responsible for all this. They havent invented from the ground up what happens on social media. In my last book, Selfie, I write about the selfie camera. Its exactly the same story. At the time, people were saying, Oh, the selfie camera has made us all narcissists, but the selfie camera was not dreamt of by Silicon Valley as a selfie camera. It was supposed to be a business meeting thing, like Zoom.

They thought thats what youre going to be doing. They didnt think we were going to be taking pictures of ourselves and uploading billions of them a day. Its the same with social media. Social media has by instinct worked out how we play status games, and kind of wrapped itself around status games and encouraged them with the follow accounts and blue badges and all that stuff. So yeah, like capitalism, it encourages it, it worsens it, but it didnt create it.

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Are humans obsessed with status? Will Storrs The Status Game makes the case. - Vox.com

Carl Jung on Psychosis and Schizophrenia – PsychCentral.com

Carl Jung made many contributions to the field of psychology but many dont realize that his thoughts on psychosis came from his own experiences.

Pioneering psychiatrist and psychoanalyst Carl Jung and founder of analytical psychology is well-known for his insights on human behavior, personality, and unconscious thought.

Jungs own symptoms of psychosis inspired him to delve deeper into the unconscious mind, though his experience was not schizophrenia as we know it today.

Carl Jungs impact on the field of psychology isnt fully defined but its certainly far reaching.

This Swiss psychologist and psychiatrist lived from 1875 to 1961. His legacy involves the interplay of spirituality with the human psyche.

He founded analytical psychology also known as Jungian psychology which focuses on symbolism in the human experience. His theories rest on the concepts of archetypes, the collective unconscious, and extraverted and introverted personalities.

Jung viewed consciousness as intertwined among all of humanity in a collective sense. He defined archetypes as shared patterns and themes that are central to the context of the human experience, like universal narratives, myths, and religious phenomena.

According to the International Association for Analytical Psychology, the four major archetypes, known as Jungian archetypes, are:

Jung used the terms psychosis and schizophrenia to describe some of his own experiences. However, he would not fit the criteria for a diagnosis today.

At 38 years old, Jung began hearing voices and having visions. He saw this as a gateway to the unconscious mind, so he actively pursued these visions and hallucinations to explore them further.

One important criterion for a modern diagnosis of schizophrenia is that it interrupts your daily life. However, Jung reported the ability to enter this state of mind as he pleased. That makes his experience of psychosis unlike that of people who receive a schizophrenia diagnosis today.

In his book, Memories, Dreams, and Reflections, Jung explains that he used active imagination to induce his hallucinations at will. According to Jung, in active imagination you latch onto a dream or fantasy image in your mind, which eventually leads to psychic processes taking over to animate it.

Between appointments, he would enter this state to better understand the unconscious mind. He explains, In order to grasp the fantasies in me underground, I knew that I had to let myself plummet down into them.

Jung believed he had to gain power over his hallucinations so he could better understand his patients.

The diagnostic process for schizophrenia today is different from what Jung thought in his day.

There are several causes for schizophrenia, including:

If you have schizophrenia, you may find it difficult to think clearly, regulate your emotions, and relate to others. The best way to receive a diagnosis for any condition is for a mental health professional to evaluate you.

To receive a diagnosis of schizophrenia, you must have had some of these symptoms affect your functioning for at least 6 months:

Jung saw schizophrenia as an abaissement du niveau mental a relaxed state of mind where the contents of your subconscious are more likely to rise to the surface. From the French, the term translates to lowering of the mental level, but some describe it as lowering of the level of consciousness.

He compared it to the experience that occurs in dreams. He used a word association test to dig deeper into the psyche of his patients because he believed every association belongs to some complex.

Mental health experts of that time referred to schizophrenia by the term dementia praecox. Jungs work focused on the similarities between dementia praecox, dreams, and the now outdated concept of hysteria.

Although Sigmund Freud and Jung worked together, their theories of the unconscious differ. Freud thought the origin of schizophrenia was a psychosexual disturbance, a phenomenon he outlined in his libido theory.

Meanwhile, Jung focused on what meaning could be derived from the symptoms his patients experienced.

Jung had theories about schizophrenia that were partly based on his own experiences he claimed he had learned to induce hallucinations at will.

However, the current definition, diagnosis, and treatments for schizophrenia have changed since then and do not match this experience or Jungs theories.

What set Jung apart from other psychiatrists is how he centered his work on schizophrenia around discovering the meanings behind the hallucinations that he and his patients experienced.

Jung brought an analytic approach to the hallucinations and delusions of his patients and sought to demonstrate that what they experienced was rich with meaning rooted in shared human experiences.

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Carl Jung on Psychosis and Schizophrenia - PsychCentral.com

Gallaher Edge Executive Team Releases New Book, The Missing Links: Launching a High Performing Company Culture – WFLA

Dr. Laura Gallaher, and Dr. Phillip Meade the co-owners of Gallaher Edge, a management consulting firm that applies the science of human behavior to create transformational change in businesses and the co-authors of the newly released book The Missing Links: Launching a High Performing Company Culture join Gayle Guyardo the host of the nationally syndicated health and wellness show Bloom to share more about their new book designed to create a better work environment.

Bloom airs in 40 more markets across the country, with a reach of approximately 36 million households, and in Puerto Rico, U.S. Virgin Islands and Madison, WI.

You can watch Bloom in the Tampa Bay Market weekdays at Noon on WTTA: Spectrum 1006; Frontier 514; DirecTV 38; Dish 38; Comcast 43, and look for Bloom early mornings on WFLA News Channel 8.

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Gallaher Edge Executive Team Releases New Book, The Missing Links: Launching a High Performing Company Culture - WFLA