Genetics

Myriad Genetics Partners with Epic Systems to Make Test Results Available in EMR – GenomeWeb

NEW YORK Myriad Genetics on Thursday said that through a partnership with Epic Systems doctors will be able to order its genetic tests and view patients' results directly within the electronic medical records platform hosted by the software company.

The integration, slated to go live later this year, "creates a seamless, end-to-end workflow solution for healthcare providers to order Myriad tests and review results directly within their everyday Epic platform without additional steps or manual ordering processes," Myriad said in a statement announcing the partnership.

Epic's EMR platform is used by 600,000 physicians to manage the records of 250 million patients. Healthcare providers have long expressed frustration with how difficult it is to access genomic test results within EMRs. Because the reports tend to exist as PDFs and not as discrete fields within the EMR, healthcare institutions cannot easily analyze patients' outcomes based on their genetic test results or build decision support to help doctors identify when patients need testing. However, a few years ago, Epic introduced a genomics module with the goal of allowing healthcare providers to integrate genetic test results directly into the EMR.

At the same time, Epic has been inking partnerships with genetic testing labs like Myriad. For example, last year Epic announced a similar arrangement to make results from Foundation Medicine's comprehensive genomic profiling tests accessible through its EMR platform.

Salt Lake City-based Myriad, meanwhile, is in the midst of a strategic shift to focus its testing business on key indications such as cancer, pharmacogenomics, and prenatal testing, and make it easier for doctors to order tests and receive results through online interfaces. Earlier this year the company launched an integrated offering with Intermountain Healthcare, called Precise Oncology Solutions, through which doctors can order germline cancer risk assessments, companion tests, and somatic tumor profiling with a single order and receive tests via a unified online portal.

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Myriad Genetics Partners with Epic Systems to Make Test Results Available in EMR - GenomeWeb

Genetics

Obesity and genetics: Expert shares insights – Hindustan Times

Obesity is a health condition which involves accumulation of a large amount of fat. Unlike what we think, Obesity is not just a cosmetic condition. It, in fact, involves and increases the risk of a lot of other disorders such as heart disease, diabetes, high blood pressure and even certain types of cancers. Obesity is caused by a range of factors it usually involves eating a lot of calories and not burning enough of them which causes the fat to accumulate. Genetics is also one of the causes of obesity. Speaking to HT Lifestyle, Yash Vardhan Swami, Nutritionist, Health and Fitness Expert said, To gain weight we need to eat more calories than we burn (over time) and to lose weight, we need to eat lesser calories. To control this equation, we can eat more or fewer calories, or we can burn more or fewer calories. We can also do a bit of both.

Yash Vardhan Swami further added that this formula applies to everyone irrespective of the genetic makeup that they are a part of. Can our genes make it harder to lose weight? Certain gene variants can make it easier for us to gain weight by making it easier for us to eat more calories than what we burn over time which would lead to weight gain by increasing drive to eat (hunger and cravings) or reducing drive to move/burn calories (in simple terms, making us lazier).

ALSO READ: Health tips for adolescents: 5 problems due to obesity, ways to lose weight

The nutritionist further referred to the presence of the FTO Gene also known as the obesity gene, FTO gene is Fat Mass and Obesity Associated Gene which raises the risk of obesity. Referring to the part played by the FTO gene, the expert added, If you have one copy of gene (one parent), there would be a difference of 1.5kgs only (on an average). If you have two copies of the gene (both parents), there would be a difference of 3kgs only (on an average). So, if we are up to 3kgs up, we can blame our genetics. If it's more, genetics are not to be blamed. The expert recommended regular exercise which can reduce and slash the effect of the FTO gene and can prevent obesity.

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Obesity and genetics: Expert shares insights - Hindustan Times

Genetics

"Founder events" that reduced genetic diversity found to be common throughout human history – News-Medical.Net

Human populations have waxed and waned over the millennia, with some cultures exploding and migrating to new areas or new continents, others dropping to such low numbers that their genetic diversity plummeted. In some small populations, inbreeding causes once rare genetic diseases to become common, despite their deleterious effects.

A new analysis of more than 4,000 ancient and contemporary human genomes shows how common such "founder events" were in our history. A founder event is when a small number of ancestral individuals gives rise to a large fraction of the population, often because war, famine or disease drastically reduced the population, but also because of geographic isolation -; on islands, for example -; or cultural practices, as among Ashkenazi Jews or the Amish.

More than half of the 460 groups represented by these individuals had experienced a population bottleneck somewhere in their past that decreased their genetic diversity and likely increased the incidence of recessive hereditary diseases.

The analysis by population geneticists at the University of California, Berkeley, is the first comprehensive look at founder events across a broad swath of human populations over the past 10,000 years or so of human history and pinpoints when these events occurred.

According to the authors, the findings will be useful not only to archeologists and historians tracking the movement and mixing of populations around the world, but also to scientists and doctors studying human genetic variation. The genetic diseases of inbred populations have helped scientists find many disease-causing mutations in the human genome and discover the causes of numerous genetic and inherited diseases.

Genomic data is really powerful because it not only tells us about where we come from, it tells us about our history at various different time scales, and you can look at how closely related different individuals are to each other. But also, it tells us about bits of DNA that are functionally important and can cause diseases. So, they become quite important to study from a biomedical perspective."

Priya Moorjani, senior author, assistant professor of molecular and cell biology, UC Berkeley

Many of the populations represented by individuals in the sample were or are much more inbred than ethnic Ashkenazi Jews, who some scientists have estimated once dwindled to a population of less than a couple of thousand individuals about 1,000 years ago. The Onge, a group in the Andaman Islands of the Indian Ocean, underwent a population bottleneck 10 times more extreme than that of Ashkenazi Jews, and today it numbers only about 100 individuals.

The researchers found that many Native American populations and groups from Oceania and South Asia also suffered severe population bottlenecks. Some coincide with known historical events -; for instance, the residents of Rapa Nui (Easter Island) underwent a founder event about 260 years ago, coincident with the migration of Europeans to the island.

Others correlate well with the known movement of peoples into an area and with changing cultural artifacts and practices. For example, Anatolian farmers and Eurasian steppe pastoralists moved into Europe between about 4,000 and 10,000 years ago, and the groups intermingled with existing European hunter-gatherers.

"The first surprise was that over half the groups we surveyed had evidence for founder events," Moorjani said. "So, it's not just Ashkenazi Jews or Finns that have a unique history, but many populations living today have had strong founder events -; in fact, stronger founder events than these two groups, like several contemporary South Asian groups, hunter-gatherers or populations living on islands. And many of these groups would be really important for prioritizing functional studies. We have learned so much about genetic variation from groups like Ashkenazi Jews and Finns that the potential for discovery is really high if we can expand these studies to other worldwide populations."

Moorjani, former UC Berkeley undergraduate Gillian Chu and first author Rmi Tournebize, now a postdoctoral fellow at the Instituto Gulbenkian de Cincia in Oeiras, Portugal, published their findings today (June 23) in the journal PLOS Genetics.

The analysis was made possible by a genomics analysis program called ASCEND (Allele Sharing Correlation for the Estimation of Non-equilibrium Demography), which was created by Tournebize and Moorjani specifically to analyze partial genome sequences -; in particular, ancient DNA. This DNA is generally sequenced from bones or teeth that are hundreds to thousands of years old and represent not only our Homo sapiens ancestors, but other human groups, like Neanderthals and Denisovans.

Such DNA is typically damaged so that only a portion of the individual's genome can be sequenced. But since human genomes contain about 3 billion base pairs of DNA, even a mere 100,000 base pairs can provide information about that person's heritage, Moorjani said. Many genome analysis programs today work only with nearly complete genome sequences, primarily from contemporaneous peoples.

"While ancient DNA is really powerful, one of the challenges is that it has much lower quality compared to data from living people, because once an individual dies, the DNA starts degrading, and it's very hard to recover very high quality data compared to present-day individuals," Moorjani said. "But the majority of the demographic inference methods are built thinking that you can get large numbers of samples from populations and high-quality data across the genome. Our methods were developed to leverage this low-coverage, highly degraded DNA to really understand our evolutionary history."

ASCEND measures the sharing of DNA between individuals within and across populations. When a population undergoes a founder event, its size dwindles to a few individuals. The offspring of these founder individuals, in turn, share long blocks in their genome that are inherited "identical by descent" from these few ancestors. As time passes, these blocks will become smaller due to crossover events that occur during meiosis, when chromosomes duplicate and mix before segregating to egg and sperm cells. The rate of crossovers is well characterized and provides a kind of molecular clock. The ASCEND program compares how large the shared blocks are within individuals in a population to infer when the individuals might have shared a common ancestor, i.e., when a founder event occurred in the population's history. A large-scale, pair-wise statistical comparison of genomic DNA allows an estimation of when and how intense the bottleneck was.

The genome data came from the Allen Ancient DNA Resource, a database created by David Reich and collaborators at Harvard University, with whom Moorjani earned her Ph.D. The public database currently includes available present-day and ancient genomes from more than 14,000 individuals and more than a million common mutations or variants -; single nucleotide polymorphisms, or SNPs -; within those DNA sequences. At the time Moorjani started her study, the database held fewer ancient and modern genomes. She and Tournebize focused on the genomes of 2,310 present-day individuals from 184 groups, then expanded their study to look at an additional 1,947 individuals representing 164 worldwide ancient populations.

"Applying this method, we uncovered founder events that had not been identified previously, for instance, in populations from ancient Morocco or Siberia," Tournebize said. "As a French guy, I was really surprised to discover a founder event in Basque people, dated around the 1st century BCE and possibly related to Roman colonization of this region. We'll need more genetic data, especially from ancient samples, and collaboration with social scientists to understand the detailed historical events that might be associated with this bottleneck."

To test the ASCEND program in other species, Moorjani and Tournebize turned to dogs. The genome sequences of about 40 modern dog breeds are available, so the researchers ran them through the program to determine how long ago founder events occurred in breeds ranging from African village dogs -; the least inbred -; to breeds like boxers, dobermans and rottweilers, the most inbred. Consistent with the establishment of many dog breeds during Victorian times, they confirmed extreme founder events in most breeds within the last 25 generations, that is, 75 to 125 years.

"Dogs are so interesting that it was exciting to expand the analysis to another species, but it was really sad to see how strong the founder events are," she said. "Most dogs these days have so many more problems than village dogs. Their rates of cancers and congenital diseases are pretty high. And that's largely because of these very severe founder events in their history during breed formation."

In another recent paper, Moorjani and her colleagues described a different genomics analysis program that analyzes a single individual's genome, whether complete or partial, and estimates the amount of admixture of other populations over time. The researchers used this program, called DATES (Distribution of Ancestry Tracts of Evolutionary Signals), to analyze about 1,100 ancient genomes and reconstruct major gene flow events in Europe since about 10,000 BCE.

One surprising finding was that the genomes of Anatolian farmers, who lived in what is today Turkey, show admixture of genes from Iranian Neolithic farmers long before the advent of agriculture in Anatolia. This suggests that farming did not originate in Anatolia, as many archeologists have suggested.

"We had samples of Anatolian hunter-gatherers who don't have Iranian ancestry and samples of Anatolian early farmers who have Iranian ancestry, but we didn't know when this mixture occurred," she said. "In our case, we were able to actually figure out the key time point when this group formed, which predates agriculture in the region. And based on that, we are able to tell that farming must have spread through cultural diffusion, rather than having originated in Anatolia."

Another discovery was the timing for the formation of Bronze Age steppe pastoralists. These groups made a large impact, both genetically and demographically, in Eurasia during the Bronze Age and, according to some studies, are responsible for the spread of Indo-European languages. Archeological studies suggest these groups inhabited regions of the steppe in present day Russia and Ukraine from 3,300 to 2,600 BCE. Using the genetic dating method, the researchers found these groups were genetically formed between 4,400 and 4,000 BCE, predating previous findings by over a half a millennium.

"Our study emphasizes the power of dating population mixtures and formation, rather than just using temporal sampling and tracking the presence or absence of a particular ancestry in ancient samples, which is highly dependent on sampling choice and density," said UC Berkeley postdoctoral fellow Manjusha Chintalapati, first author of the paper.

Moorjani plans to use ASCEND and DATES to take a closer look at many ancient populations, in particular those in India, that have strong founder events that suggest the possibility of many unrecognized recessive diseases that could help to reduce disease burden in the group and shed light on the basic functions of human genes.

"In our analysis, we find that 64% of South Asian populations have very strong founder events, so we are trying to do targeted sample collection in these groups to characterize some of the deleterious variants due to the founder events," she said.

DATES, for example, suggests that each isolated population in South Asia has admixtures of local indigenous hunter-gatherers, Near Eastern farmers and Steppe pastoralists or herders, but in different proportions that remained the same for many hundreds of generations. Strikingly, most European populations also derive ancestry from similar three groups, though the groups have continued to freely mix with each other after the initial mixture.

"It's really exciting to do this work at Berkeley, where Allan Wilson's lab came up with the idea of a molecular clock, and to continue on his path to use genomic data for learning about the timing of different evolutionary events," Moorjani said, referring to the late biochemist and pioneer of molecular evolution, who died in 1991.

The two studies were funded by the Burroughs Wellcome Fund, a Sloan Research Fellowship and the National Institutes of Health (R35GM142978).

Source:

Journal reference:

Tournebize, R.,et al.(2022) Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals.PLOS Genetics. doi.org/10.1371/journal.pgen.1010243.

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"Founder events" that reduced genetic diversity found to be common throughout human history - News-Medical.Net

Genetics

Where science meets fiction: the dark history of eugenics – The Guardian

Its a quirk of history that the foundations of modern biology and as a consequence, some of the worst atrocities of the 20th century should rely so heavily on peas. Cast your mind back to school biology, and Gregor Mendel, whose 200th birthday we mark next month. Though Mendel is invariably described as a friar, his formidable legacy is not in Augustinian theology, but in the mainstream science of genetics.

In the middle of the 19th century, Mendel (whose real name was Johann Gregor was his Augustinian appellation) bred more than 28,000 pea plants, crossing tall with short, wrinkly seeds with smooth, and purple flowers with white. What he found in that forest of pea plants was that these traits segregated in the offspring, and did not blend, but re-emerged in predictable ratios. What Mendel had discovered were the rules of inheritance. Characteristics were inherited in discrete units what we now call genes and the way these units flowed through pedigrees followed neat mathematical patterns.

These rules are taught in every secondary school as a core part of how we understand fundamental biology genes, DNA and evolution. We also teach this history, for it is a good story. Mendels work, published in 1866, was being done at the same time as Darwin was carving out his greatest idea. But this genius Moravian friar was ignored until both men were dead, only to be rediscovered at the beginning of the new century, which resolved Darwinian evolution with Mendelian genetics, midwifing the modern era of biology.

But theres a lesser-known story that shaped the course of the 20th century in a different way. The origins of genetics are inextricably wedded to eugenics. Since Plato suggested the pairing of high-quality parents, and Plutarch described Spartan infanticide, the principles of population control have been in place, probably in all cultures. But in the time of Victorian industrialisation, with an ever-expanding working class, and in the wake of Darwinian evolution, Darwins half-cousin, Francis Galton, added a scientific and statistical sheen to the deliberate sculpting of society, and he named it eugenics. It was a political ideology that co-opted the very new and immature science of evolution, and came to be one of the defining and most deadly ideas of the 20th century.

The UK came within a whisker of having involuntary sterilisation of undesirables as legislation, something that Churchill robustly campaigned for in his years in the Asquith government, but which the MP Josiah Wedgwood successfully resisted. In the US though, eugenics policies were enacted from 1907 and over most of the next century in 31 states, an estimated 80,000 people were sterilised by the state in the name of purification.

American eugenics was faithfully married to Mendels laws though Mendel himself had nothing to do with these policies. Led by Charles Davenport a biologist and Galton devotee the Eugenics Record Office in Cold Spring Harbor, New York, set out in 1910 to promote a racist, ableist ideology, and to harvest the pedigrees of Americans. With this data, Davenport figured, they could establish the inheritance of traits both desirable and defective, and thus purify the American people. Thus they could fight the imagined threat of great replacement theory facing white America: undesirable people, with their unruly fecundity, will spread inferior genes, and the ruling classes will be erased.

Pedigrees were a major part of the US eugenics movement, and Davenport had feverishly latched on to Mendelian inheritance to explain all manner of human foibles: alcoholism, criminality, feeblemindedness (and, weirdly, a tendency to seafaring). Heredity, he wrote in 1910, stands as the one great hope of the human race; its saviour from imbecility, poverty, disease, immorality, and like all of the enthusiastic eugenicists, he attributed the inheritance of these complex traits to genes nature over nurture. It is from Davenport that we have the first genetic studies of Huntingtons disease, which strictly obeys a Mendelian inheritance, and of eye colour, which, despite what we still teach in schools, does not.

One particular tale from this era stands out. The psychologist Henry Goddard had been studying a girl with the pseudonym Deborah Kallikak in his New Jersey clinic since she was eight. He described her as a high-grade feeble-minded person, the moron, the delinquent, the kind of girl or woman that fills our reformatories. In order to trace the origin of her troubles, Goddard produced a detailed pedigree of the Kallikaks. He identified as the founder of this bloodline Martin Kallikak, who stopped off en route home from the war of independence to his genteel Quaker wife to impregnate a feeble-minded but attractive barmaid, with whom he had no further contact.

In Goddards influential 1912 book, The Kallikak Family: A Study in the Heredity of Feeble-Mindedness, he traced a perfect pattern of Mendelian inheritance for traits good and bad. The legitimate family was eminently successful, whereas his bastard progeny produced a clan of criminals and disabled defectives, eventually concluding with Deborah. With this, Goddard concluded that the feeble-mindedness of the Kallikaks was encoded in a gene, a single unit of defective inheritance passed down from generation to generation, just like in Mendels peas.

A contemporary geneticist will frown at this, for multiple reasons. The first is the terminology feeble-minded, which was a vague, pseudopsychiatric bucket diagnosis that we presume included a wide range of todays clinical conditions. We might also reject his Mendelian conclusion on the grounds that complex psychiatric disorders rarely have a single genetic root, and are always profoundly influenced by the environment. The presence of a particular gene will not determine the outcome of a trait, though it may well contribute to the probability of it.

This is a modern understanding of the extreme complexity of the human genome, probably the richest dataset in the known universe. But a meticulous contemporary analysis is not even required in the case of the Kallikaks, because the barmaid never existed.

Martin Kallikaks legitimate family was indeed packed with celebrated achievers men of medicine, the law and the clergy. But Goddard had invented the illegitimate branch, by misidentifying an unrelated man called John Wolverton as Kallikaks bastard son, and dreaming up his barmaid mother. There were people with disabilities among Wolvertons descendants, but the photos in Goddards book show some of the children with facial characteristics that are associated with foetal alcohol syndrome, a condition that is entirely determined not by genetic inheritance, but by exposure to high levels of alcohol in utero. Despite the family tree being completely false, this case study remained in psychology textbooks until the 1950s as a model of human inheritance, and a justification for enforced sterilisation. The Kallikaks had become the founding myth of American eugenics.

The German eugenics movement had also begun at the beginning of the 20th century, and grown steadily through the years of the Weimar Republic. By the time of the rise of the Third Reich, principles such as Lebensunwertes Leben life unworthy of life were a core part of the national eugenics ideology for purifying the Nordic stock of German people. One of the first pieces of legislation to be passed after Hitler seized power in 1933 was the Law for the Prevention of Genetically Diseased Offspring, which required sterilisation of people with schizophrenia, deafness, blindness, epilepsy, Huntingtons disease, and other conditions that were deemed clearly genetic. As with the Americans tenacious but fallacious grip on heredity, most of these conditions are not straightforwardly Mendelian, and in one case where it is Huntingtons the disease takes effect after reproductive age. Sterilisation had no effect on its inheritance.

The development of the Nazis eugenics programmes was supported intellectually and financially by the American eugenicists, erroneously obsessed as they were with finding single Mendelian genes for complex traits, and plotting them on pedigrees. In 1935, a short propaganda film called Das Erbe (The Inheritance) was released in Germany. In it, a young scientist observes a couple of stag beetles rutting. Confused, she consults her professor, who sits her down to explain the Darwinian struggles for life and shows her a film of a cat hunting a bird, cocks sparring. Suddenly she gets it, and exclaims, to roars of laughter: Animals pursue their own racial policies!

The muddled propaganda is clear: nature purges the weak, and so must we.

The film then shows a pedigree of a hunting dog, just the type that you might get from the Kennel Club today. And then, up comes an animation of the family tree of the Kallikaks, on one side Erbgesunde Frau and on the other, Erbkranke Frau genetically healthy and hereditarily defective women. On the diseased side, the positions of all of the miscreants and deviants pulse to show the flow of undesirable people through the generations, as the voiceover explains. Das Erbe was a film to promote public acceptance of the Nazi eugenics laws, and what follows the entirely fictional Kallikak family tree is its asserted legacy: shock images of seriously disabled people in sanatoriums, followed by healthy marching Nazis, and a message from Hitler: He who is physically and mentally not healthy and worthy, may not perpetuate his suffering in the body of his child. Approximately 400,000 people were sterilised under this policy. A scientific lie had become a pillar of genocide in just 20 years.

Science has and will always be politicised. People turn to the authority of science to justify their ideologies. Today, we see the same pattern, but with new genetics. After the supermarket shootings in Buffalo in May, there was heated discussion in genetics communities, as the murderer had cited specific academic work in his deranged manifesto, legitimate papers on the genetics of intelligence and the genetic basis of Jewish ancestry, coupled with the persistent pseudoscience of the great replacement.

Science strives to be apolitical, to rise above the grubby worlds of politics and the psychological biases that we are encumbered with. But all new scientific discoveries exist within the culture into which they are born, and are always susceptible to abuse. This does not mean we should shrug and accept that our scientific endeavours are imperfect and can be bastardised with nefarious purpose, nor does it mean we should censor academic research.

But we should know our own history. We teach a version of genetics that is easily simplified to the point of being wrong. The laws in biology have a somewhat tricksy tendency to be beset by qualifications, complexities and caveats. Biology is inherently messy, and evolution preserves what works, not what is simple. In the simplicity of Mendels peas is a science which is easily co-opted, and marshalled into a racist, fascist ideology, as it was in the US, in Nazi Germany and in dozens of other countries. To know our history is to inoculate ourselves against it being repeated.

This article was amended on 20 June 2022. The mass shooting in Buffalo, US, in May 2022 was at a supermarket, not a school as an earlier version said.

Control: The Dark History and Troubling Present of Eugenics by Adam Rutherford is published by Weidenfeld & Nicolson (12.99). To support the Guardian and Observer order your copy at guardianbookshop.com. Delivery charges may apply

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Where science meets fiction: the dark history of eugenics - The Guardian

Genetics

Headaches and genetics: If migraines are hereditary, what are possible solutions? – Genetic Literacy Project

The GLP Needs Your Help

The biotechnology revolution in biomedicine, farming, and gene drives to eradicate pests has yielded enormous benefits, but future success is not assured. It is easier than ever for advocacy groups to spread disinformation on pressing science issues or for corporations to capture innovation for its own benefit. To inform the public about whats really going on, we present the facts and challenge those who don't. We cant do this without your help. Please support us a donation of as little as $10 a month helps support our vital myth-challenging efforts.

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Headaches and genetics: If migraines are hereditary, what are possible solutions? - Genetic Literacy Project

Genetics

Genetics Really Said Copy And Paste: People Are Amazed At How Similar This Woman Looks To Her Dad In These 5 Recreation Photos – Bored Panda

Fathers Day is celebrated on different days in various places around the world, but most of them honor their dads on the third Sunday in June. Somehow it is always so difficult to come up with an idea of what could be the best present to show our love to our dads as they rarely need anything, and actually, nothing seems good enough to express our gratitude.

But what it takes is just a little bit of creativity. This woman on TikTok decided that she could recreate some of her dads photos from his youth and make a cute video for him, showing how similar they actually look.

More info: TikTok

Image credits: lakynthrifts

TikToker lakynbowman, also known as Lakyn Bowman, is a 26-year-old woman from West Tennessee who has a business of transforming her thrift finds into home decor to promote sustainability.

She is also quite busy creating content on social media, especially on TikTok, where she shares her thrift finds for her home, her business and also shows what outfits can be composed of second-hand clothing.

Image credits: lakynthrifts

Image credits: lakynthrifts

Bored Panda has already talked about one of her videos that went viral with 8.8 million views a few months ago. In that video, Lakyn decided to recreate her grandmothers photos from when she was young as a gift for her birthday.

She wanted to surprise her grandma and did her hair and makeup exactly like in the pictures. The granddaughter also found some clothes that looked very similar and posed in the same way as her grandma did. If you would like to read more, you can follow this link.

Image credits: lakynbowman

This time we are looking at her latest photo recreation video that she dedicated to her dad in honor of Fathers Day. She again found similar-looking clothes and manipulated her hair to look like she had a short bob like her dad when he was a kid. She nailed the poses and the comparison shots are proof that these two people are definitely family.

Lakyn herself confessed in the text overlay in the video that she was a bit freaked out looking at her dads old photos and seeing how much the two of them look alike, and its fascinating to observe with the naked eye how genes work.

Image credits: lakynbowman

Image credits: lakynbowman

While seeing photos side by side is very satisfying, the best part about this gift was the dads reaction. Lakyn posted a video of her dad watching the montage for the first time and it made the dad quite emotional as he couldnt stop smiling.

The man recognized his jersey and his coat, praising his daughter for doing such a good job. Actually, he was so impressed that he wanted to see the video a couple of more times.

You can hear Lakyn asking her dad which of the recreations he liked the most and his answer was I like all of them! But he was especially happy about the one in which she was wearing a red jacket because it was the actual jacket he wore in that photo.

The dad also revealed a little bit of more context to the photo in which he was wearing a blue shirt. Apparently, he was a cheerleader for a while because he wasnt allowed to play more than 2 basketball games on a weekend, so he asked if he could participate in the game as a cheerleader.

Image credits: lakynbowman

Image credits: lakynbowman

The dad said that he remembered all of the photos and you could see the nostalgia in his eyes reminiscing about the times he did sports. He also said that he really misses his dark hair, as now it has silver strands in it.

He noticed that Lakyn even has his eyebags and they both agreed that Lakyn is definitely her fathers kid. Lakyn confessed that she was really excited to do this because couldnt grasp how her face could be so similar to her dads.

Image credits: lakynbowman

Image credits: lakynbowman

Before surprising her dad with the video, Lakyn did one for her mom on Mothers Day as well. Lakyn isnt so sure that she has any physical similarities with her mom, but she has heard from some people that they do. With the power of makeup, clothes, poses and filters, it would be hard to think that the two women are strangers.

Moms reaction was as wholesome as the dads. She loved the result and told Lakyn that the swing picture in the park was actually taken by her, even though she didnt remember that because she was so little.

Image credits: lakynbowman

Its quite impressive how children can grow up looking so similar to their parents and even though its easily explained by science, its mesmerizing nonetheless.

Have you ever looked at your parents pictures from their youth and were surprised to discover you now look like them? Do you see the similarities between Lakyn and her dad in these pictures? Let us know in the comments!

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Genetics Really Said Copy And Paste: People Are Amazed At How Similar This Woman Looks To Her Dad In These 5 Recreation Photos - Bored Panda

Genetics

Dubrovnik Hosts International Conference on Anthropological Genetics and Forensics – Total Croatia News

June the 24th, 2022 - Dubrovnik hosts the 12th International Conference on Anthropological Genetics and Forensics, which saw 550 scientists, doctors and other experts from across Europe and the rest of the world descend on the Pearl of the Adriatic.

As Morski writes, the 12th International Conference on Anthropological Genetics and Forensics brought together the above-mentioned number of individuals from various prestigious European and international universities and institutions to discuss forensics and personalised medicine in Dubrovnik on Thursday.

The conference was organised by the International Society for Applied Biological Sciences ISABS, the American Mayo Clinic and the Sv Katarina (St. Catherine) Special Hospital. ISABS President Dragan Primorac pointed out that the congress will primarily answer what the medicine of the future will look like.

''First of all, I'm referring to the development of pharmacogenomics, gene cell therapy in the treatment of a number of degenerative diseases, as well as cancer. The future of medicine is to break out of the clichs of the medical tradition. The new concept is personalised medicine, and that means that the right therapy goes to the right patient at the right time, which we can find out more about by analysing glycomics, genomics, proteomics and epigenomics. Those who don't accept that will not be competitive on the global market,'' said Primorac.

Dubrovnik hosts many famous names, and this time three Nobel laureates also took part in the congress: Sir Richard Roberts, Thomas Sdhof and Aaron Ciechanover, and Primorac has announced that they will work with about 200 students from the USA, Europe and Croatia.

Minister of Science and Education Radovan Fuchs pointed out that, in addition to the level of scientific thought and new achievements, the congress opened up opportunities for students to network and gain some new experiences.

''It's very important for young people. I'd especially like to emphasise forensics, but personalised medicine is also becoming more and more popular across the world, and that is certainly the future,'' said Fuchs.

Minister of the Interior Davor Bozinovic noted that the Ivan Vucetic Police Academy and the Centre for Forensic Investigations, Research and Expertise are scientific institutions within the Ministry of the Interior (MUP).

''Perhaps it's less known that these organiaational units of the Ministry of the Interior have scientific licenses, and in terms of forensics, the Ivan Vucetic Centre has an important role to play. The chief is a member of the American Academy of Forensics. We're at the very top of the global scale and we're certainly a leader in this part of Europe,'' said Bozinovic.

In cooperation with the American Academy of Forensic Sciences, the conference discussed new forms of cancer treatment, pharmacogenomics, translational and personalised medicine, gene and molecular therapy and diagnostics, regenerative medicine and the use of stem cells in treatment, as well as other achievements of modern scientific research.

For more on conferences and congresses Dubrovnik hosts, make sure to check out our dedicated lifestyle section.

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Dubrovnik Hosts International Conference on Anthropological Genetics and Forensics - Total Croatia News

Genetics

Earlham woman loses weight with ChiroThin after her own doctor told her "genetics" wouldn’t allow that to happen | Paid Content – Local 5 -…

PAID CONTENT | Earlham's Judy Marshall went to her primary care physician for help with losing weight...he told her that "genetics" would not allow that to happen. Judy changed doctors looking for an answer...their answer was a bunch of pills. Judy decided to visit with Dr. Vince Hassel to see if the ChiroThin system would be the solution to her weight loss and health goals. The answer is a BIG YES! She lost 20-25 pounds on the program and is now even more focused on her own well-being and is ecstatic with the results! If you follow his advice and stick to the program, Dr. Hassel's plan WILL WORK where other's fail, period. LEARN MORE at http://www.weightlossindesmoines.com or call/text 515-423-8396

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Earlham woman loses weight with ChiroThin after her own doctor told her "genetics" wouldn't allow that to happen | Paid Content - Local 5 -...

Genetics

Science and genetics used to boost Fernside farm – New Zealand Herald

Fernside dairy farmer Julie Bradshaw is passionate about the ability of genetics to create the most efficient herd of cows. Photo / Supplied

A five-year irrigation study has helped Julie Bradshaw make science-based decisions on her Fernside dairy farm.

Bradshaw also uses genetics to improve her herd, as part of her goal to reduce her farm's environmental footprint.

Bradshaw took part in the National Institute of Water and Atmospheric Research (NIWA) co-innovation study from 2016 to 2021.

The study provided landowners with real-time data and forecasts to make science-based irrigation decisions.

This data included measured rainfall, soil moisture, soil temperature, drainage and estimated evaporation, as well as two, six and 15-day rainfall and weather forecasts.

The practical study gave each farmer a fantastic insight into their own land and irrigation practices, while also providing a broader picture of what was happening in the catchment, Bradshaw said.

Having access to precise data also helped Bradshaw and her neighbouring farmers to apply exactly the right amount of irrigation and fertiliser at the right time which aided in mitigating environmental impacts.

"It was amazing. We had so much data and information that we had never had before," she said.

"[This] has helped us make decisions about irrigation and fertiliser use ... backed up by facts and scientific data."

Having these records also made it easier for Farm Environment Plans and audits, Bradshaw said.

"We can show that we have been using our water resource correctly."

All farmers involved in the study were able to see each other's data and this high level of transparency helped the group understand what was happening in various parts of the catchment, Bradshaw said.

"We have always been very open - it's just information and data about water. Getting to know more about other farms is helpful because we are learning from each other along the way."

Although the study had ended, Bradshaw still logged in to the group's website most days to enable her to make accurate decisions about water allocation for the Cust Main Drain Water User's Group.

The group was established 25 years ago to manage water allocation during the irrigation season when water takes were restricted.

"It has been such a bonus to be able to see where everyone is sitting in terms of the moisture on their paddocks, as this helps me to allocate the water more accurately to where it is needed.

"Not only do you see today's moisture levels but you also get a future reading, so you can see where things are heading."

Last year Bradshaw and her husband Peter received the Sire Proving Scheme Farmers of the Year Award from the Livestock Improvement Corporation (LIC).

The couple had worked with LIC for 15 years and the award recognised their record-keeping and commitment to having their entire herd DNA-tested.

"We have a KiwiCross herd which is a cross between Holstein-Friesian and Jersey cows," she said.

"I am really passionate about the ability of genetics to improve your overall herd quality. Having 99 per cent of the ancestry of the cows recorded is an immense help when doing the breeding."

Bradshaw believed improving the overall quality of the herd meant, that if she needed to reduce her stock levels in the future, she knew exactly which animals had the best genetics to meet future farming limits.

She was committed to using science to reduce her impact on local waterways.

"Genetics and DNA testing are so helpful when you think about the possibility of reducing herd numbers in the future.

"We must think ahead and use science to help us make the best decisions both for our business operation and for the environment."

Bradshaw was also participating in a six-month farming project, which examined how the next generation of farmers used innovation to improve their practices.

Waimakariri Landcare Trust (WLT) and Waimakariri Irrigation Limited (WIL) have partnered with the Ministry for Primary Industries (MPI) for this project, with support from MPI's Sustainable Food and Fibre Futures fund, along with Environment Canterbury, Ballance, and DairyNZ.

Bradshaw aimed to learn more about genetics through the course of the MPI innovation project.

"We have three cows that LIC would like a bull calf out of, so that will be an interesting process to follow.

She was also keen to use the MPI innovation project to improve the quality of the grass throughout the farm.

"With the colder and wetter spring we had last year, followed by a cloudy and cooler summer, our grass didn't contain enough sugar and energy for the cows. We want to work on that throughout this project."

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Science and genetics used to boost Fernside farm - New Zealand Herald

Neuroscience

Neuroscience Undergraduate Major

Neuroscience is the multidisciplinary study of the nervous system. A major in Neuroscience provides a broad background in this highly interdisciplinary scientific field, ranging from Molecular/Cellular to Circuits/Systems and to Cognitive/Behavioral Neuroscience. The major is administered by the Program in Fundamental Neuroscience (PFN), with courses offered within the Major (NESC), as well as in Biology, Psychology, and other departments. Students are encouraged to perform independent research in laboratories across the grounds and to proceed to the Distinguished Majors Program.

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Neuroscience Undergraduate Major