Dihydropyridine (DHP) Market Insights 2022 And Analysis By Top Keyplayers Shenzhen Simeiquan Biotechnology, Boc Sciences, Weifang Union Biochemistry,…

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Study of Competitive Landscape

It starts with an overview of the supplier landscape followed by industry concentration analysis and ranking of the major players in the global Dihydropyridine (DHP) market. In the competitive scenario, our analysis shed light on the following topics.

LeadingDihydropyridine (DHP) Market Players are as followed:

Global Dihydropyridine (DHP) Market segmentation :

Dihydropyridine (DHP) Market Segment by Type :

Dihydropyridine (DHP) Market Segment by Application :

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Dihydropyridine (DHP) Market Report Scope

Regional market analysis Dihydropyridine (DHP) can be represented as follows:

This part of the report assesses key regional and country-level markets on the basis of market size by type and application, key players, and market forecast.

The base of geography, the world market of, Dihydropyridine (DHP) has segmented as follows:

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Scientists unravel the neuronal metabolism in learning and memory – News-Medical.Net

Exploring the predictive properties of neuronal metabolism can contribute to our understanding of how humans learn and remember. This key finding from a consideration of molecular mechanisms of learning and memory conducted by scientists from Russia and the U.S. has been published in Neuroscience & Biobehavioral Reviews.

The emerging trend in neuroscience is to consider the work of neurons as anticipatory and future-oriented, although this approach is not yet mainstream and features in just a few publications. In a paper entitled 'Neuronal metabolism in learning and memory: The anticipatory activity perspective,' Yuri I. Alexandrov, HSE Professor and Head of the V.B. Shvyrkov Laboratory of Psychophysiology at the Russian Academy of Sciences Institute of Psychology, and Mikhail V. Pletnikov, Professor of the Department of Physiology at the State University of New York, University at Buffalo, argue that neurons behave proactively because they strive to survive-; just as all living organisms. Neurons use microenvironmental metabolites as 'food', and neuronal impulse activity is aimed at obtaining these metabolites. Rather than responding to an incoming signal, neurons proactively trigger an influx of needed substances to the cell, such as neurotransmitters.

When a specialized set of our neurons fire together, we act to obtain a behavioral outcome, while the neurons also obtain their own micro-outcome in the form of needed metabolites. This process can be described as metabolic cooperation of cells, involving not only neurons but also glial, somatic, glandular, muscle and other cells throughout the body. This principle of how cells work is central to learning, which essentially means creating systemwide groups of metabolically cooperating cells that drive human behavior."

Yuri Alexandrov, Professor at HSE School of Psychology

The researchers note that for a long time, the 'stimulus-response' paradigm was dominant in the study of molecular mechanisms of learning and memory; it was assumed that just as the entire human body responds to environmental stimuli, neurons respond to incoming impulses which cause excitation of certain parts of the neuron's membrane. The neuron either fires or does not fire, depending on whether or not the excitation reaches a certain threshold.

Back in 1930s1970s, the Russian physiologist Peter Anokhin developed his theory of functional systems, including the concept of 'integrative activity of neurons', according to which a neuron's excitation causes intraneuronal chemical processes-; rather than a summation of local excitations on the membrane. These chemical processes lead to a neuronal spike.

Building on Anokhin's theory, his student Vyacheslav Shvyrkov and colleagues developed a systems-oriented approach to the study of neurons. However, Anokhin's understanding of the sequence of events was traditional: excitation of a neuron comes first, followed by a response.

'An important recent step in understanding how neurons work has been the idea that a neuron's anticipatory activity, rather than an external impulse, is what comes first. The neuron does not respond to incoming excitation but proactively triggers an influx of activity,' Alexandrov explains.

The authors argue that exploring systemwide intercellular metabolic cooperation as a learning mechanism could be a promising area of focus for further experimental research.

This approach, they believe, could lead to breakthroughs in studying the behavior of malignant cells and in developing new cancer treatments.

'Malignancies consist of cells that metabolically cooperate not only with their immediate environment but also with other cells in the body. We plan to conduct experimental studies to explore tumor cell responses to diametrically opposed individual behaviors, such as striving towards a desirable event or avoiding an undesirable or dangerous one. This can give us insight into how various systemwide cellular integrations impact tumor cells' survival. As a result, we hope to propose an effective approach to influencing tumor cells through human behavior, Alexandrov concludes.

Source:

Journal reference:

Alexandrov, Y.I., et al. (2022) Neuronal metabolism in learning and memory: The anticipatory activity perspective. Neuroscience & Biobehavioral Reviews. doi.org/10.1016/j.neubiorev.2022.104664.

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Scientists unravel the neuronal metabolism in learning and memory - News-Medical.Net

How to be less judgmental on social media and in real life – Vox.com

Casting judgment on others has never been so easy. Social media gives onlookers the opportunity to scoff at a persons every choice, from how they dress to what they feed their children. How people have behaved during the pandemic has inspired plenty of judgment in its own right: At the height of restrictions, adherence or lack thereof to masking and social distancing measures practically became barometers of peoples characters, indicating a lack of personal responsibility and empathy or an abundance of hysteria and over-caution, depending on your views.

While it gets a bad rap, in pre-modern times, judgment helped keep people safe. Judgments were alarm bells allowing humans to distinguish between toxic and harmless food, trustworthy and untrustworthy tribe members, and hardworking and lazy kinspeople, explains psychologist Carla Marie Manly, author of Joy From Fear: Create the Life of Your Dreams by Making Fear Your Friend.

Judgment is also a signal that someones behavior is unusual or out of context to your particular in-group, says Adam Moore, lecturer of psychology at the University of Edinburgh, who studies judgment and decision making. The role that automatic judgment plays, Moore says, is social signaling, social norm reinforcing.

But in todays mobile, digitally facilitated world, judgment can take on new, toxic forms, Moore says. When you silently cast judgment on someone from afar based on an Instagram story, you dont get feedback from other people or even the subject of your judgment and you dont learn how to make comments or critiques in a constructive way. Normally in a social situation, you judge somebodys behavior, and their response to you helps to calibrate your interaction with them, and also the responses of other people around you, Moore says. Because so much of our lives are disconnected from each other we dont perceive that body language and we dont perceive that social feedback anymore.

Digital platforms also incite and prioritize outrage and conflict, making it easy to look down on others from your moral high horse. When people are constantly sneering at others on public platforms, the perception of what normal social judgments should look like is skewed. In normal communities and in normal, functional families, passing judgment on other peoples behavior, it functions very well, Moore says. Families rarely break up because somebody says, Hey, youre acting like a jerk at a Fourth of July party.

While judgments help signal social norms and allow us to identify our people, mean-spirited critiques are unproductive. Discernment, on the other hand, can help you identify unhealthy and toxic behaviors, Manly says. In todays polarized world, its important to detect when someones attitudes and beliefs pose a threat to others rights and well-being. Unless someones behavior is actively harming themselves or others (in which case, you should name the behavior, tell the other person how youre feeling, and set boundaries on how youd like them to act moving forward), learning to curb petty moral righteousness is possible, but requires slowing down your thoughts and having some empathy.

If youre motivated to stop hurtful critiques, you have to evaluate their source. When you feel a twang of annoyance when a friend impulsively books a vacation despite constantly complaining about money, ask yourself why youre upset by this behavior or what purpose your anger or annoyance serves in this instance. Anger is often a signal that another person isnt taking your well-being into consideration or theres a conflict, Moore explains. Does your friends last-minute trip conflict with upcoming plans the two of you have or is it simply something you wouldnt personally do?

Do I have any reason to demand that other people in this situation care more about me than whatever signal theyre trying to send? Moore says. Even if the answer to that question is yes, having to stop and think about it often turns the volume down on things.

In order to reframe judgmental thoughts, you need to catch them in the act. We have to pull back and go, Im being judgy, I dont really want to do that, Manly says. If you find yourself whispering a snide remark to your friend about a strangers shoes, try to reframe the judgment by complimenting the persons confidence, for instance. Just as being judgmental is a practiced habit, so is stopping thought patterns that lead to hurtful observations and assumptions. If we come to notice were doing something that is unhealthy and pause and stop it, then we are far less likely to go down that path, Manly says. Thats why I like compensating because if I do catch myself doing something thats comparative, rather than just noticing, I give myself other positive hits [like] look at their beautiful smile.

Manly also suggests looking back on previous moments of judgment and thinking about what you could do better next time. Recall a moment you made a judgmental remark. What was the response? Would the statement make someone feel better about themselves if they heard it? Do you feel better about yourself having remembered it? If not, allow these reflections to guide you so the next time you see someone talking on speaker phone on the subway, for example, you can instead internally marvel at their interesting phone case instead of scoffing at having to hear their entire conversation.

When people buck social conventions, those casting judgments are often quick to be offended before considering a reason why someone else is engaging in that behavior. Say your colleague is quitting their job before landing a new one and youre outraged at their irresponsibility. Instead of jumping to conclusions, get curious and ask them about their reasons for resigning or what they hope to accomplish during their time off. Curiosity is the antidote for judgment, Manly says. Manly suggests meeting those youre unjustly judging with compassion: hoping theyre happy and doing well.

When it comes to differences of opinion, it can be easy to assume that someone who doesnt share your beliefs is evil or stupid, Moore says. Instead of reacting aggressively in an attempt to change their mind, Moore suggests thinking of a good-faith reason why someone would think this way as a means to slow down the judgment process. What does the person youre judging know about their behavior or beliefs that you dont know?

For example, when it comes to relatives with differing political opinions, Moore suggests thinking about how the loved one ended up believing what they believe: the media they consume, the people they surround themselves with. I find that helps me to not make toxic judgments about other peoples motivations, he says. Its really, really easy and very, very tempting to assume that people who disagree with you about something that you believe in very strongly or have very strong beliefs about are evil or stupid.

Of course, you should never compromise on important moral and social issues, Moore says. Relationships with people whose views are antithetical to your own will have to be renegotiated and youll need to decide how to move forward if you want to maintain contact. But you can control your initial assumptions of them based on their beliefs. What function is expressing those judgments serving right now? Moore says. Am I trying to build consensus about an issue or am I just trying to wave my flag and say Im of the red tribe or the blue tribe or the green tribe?

There are very few things you can do to convince people your way of thinking and living is ideal. Save for the occasions where someones behavior is dangerous and harmful, Manly says to focus only on what you can control. We can only control our behaviors, our thoughts, and our actions.

Many human behaviors are actions signaling to others what kind of person you are or what groups you belong to, Moore says. Instead of criticizing your aunt for constantly sharing bizarre Minion memes on Facebook, consider shes just vocalizing her membership in the coalition of Minion-lovers. Understanding actions underlying meanings can help you avoid pointless arguments trying to sway someone to your side of an issue.

Instead of judging and attacking and hoping others see your way, sympathize with others reasoning for their actions, dont feed into toxic thoughts, and lead by example.

You cant make somebody value the things that you value, Moore says. All you can do is try to gently demonstrate that valuing the things that you value makes the world around you better and people will want to move there in some intellectual or moral sense.

Even Better is here to offer deeply sourced, actionable advice for helping you live a better life. Do you have a question on money and work; friends, family, and community; or personal growth and health? Send us your question by filling out this form. We might turn it into a story.

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Top Virus Expert Warns Boosted People to Do This "As Soon as" They Can – Best Life

If you've felt like COVID's stronghold on the U.S. has loosened over the last few months, you're hardly alone. In fact, most Americans now say that their lives are looking more and more like they did pre-pandemic. According to a poll from the Associated Press-NORC Center for Public Affairs Research and the SCAN Foundation, 54 percent of adults feel their lives are somewhat the same as before and 12 percent feel that their lives are exactly the same today as they were before the pandemic hit. COVID cases are falling at the moment, with the Centers for Disease Control and Prevention (CDC) reporting a more than 5 percent decrease in new daily infections this week compared to last.

READ THIS NEXT: Dr. Fauci Just Said Virus Experts Are "Very Concerned" About This.

But the coronavirus is far from eradicated. Many virus experts have warned about a potential surge later this year, as the fall and winter seasons have already proved to be the most dangerous times for COVID's spread. Thomas Campbell, MD, an internal medicine physician who ran clinical trials for COVID vaccines, told UCHealth in Aurora, Colorado, that it's "important to plan for another wave in the fall and winter because there's a good probability that it will happen," as COVID will likely continue to spread due to a variety of factors.

"Both vaccine-induced immunity and immunity from natural infection wane over time. We have a virus that's still here along with waning immunity. And human behavior changes in the fall," Campbell explained. "Kids will go back to school. The weather will be colder. The daylight hours will be shorter, so people will be indoors more and having more contact with other people. Then, we'll have Thanksgiving, Christmas, and New Year's, and travel associated with the holidays We have all the ingredients necessary to create a new wave."

The continued emergence of new Omicron subvariants is also likely to aid a future COVID surge, which is why vaccine manufacturers like Pfizer and Moderna have started to "create new, tailored versions of their booster shots that will better combat Omicron variants," according to UCHealth. On June 30, an advisory committee for the U.S. Food and Drug Administration (FDA) recommended approval for these new Omicron-specific booster vaccine formulas.

"The original vaccines and boosters did not specifically fight these Omicron variants because they hadn't developed yet," UCHealth further explained. "The vaccine makers have pledged to deliver the new doses by fall."

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But the likelihood of new booster shots has some people questioning when they should be getting their additional doses. Everyone over the age of 5 is eligible for a singular booster shot at least five months after their primary vaccine series, according to the CDC.A second booster is also available to adults who are 50 and older, as well as those 12 and older who are moderately or severely immunocompromised, once it has been at least four months since they received their first boost.

The CDC reports that nearly half of those fully vaccinated have gotten their first booster shot so far, but vaccination rates for the second booster are much lower. This may be partly because some people are unsure if they should be waiting for this additional dose, whether to better time it with the expected fall COVID surge or to get the new Omicron-specific booster formula. If you're holding out for one of these reasons, virus experts have a clear warning: Don't wait to get the second booster.ae0fcc31ae342fd3a1346ebb1f342fcb

"There is a high level of community transmission right now, so it's better to get it as soon as you are eligible to allow time to build up antibodies," Hannah Newman, MPH, the director of infection prevention at Lenox Hill Hospital in New York City, told WebMD. According toAmesh Adalja, MD, an assistant professor at the Bloomberg School of Public Health at Johns Hopkins University, it takes "probably seven days or so until you reach the peak protection for the immune system to have reacted."

Campbell also advised against waiting for a second booster, urging boosted individuals to get it as soon as possible as new variants continue to spread and vaccine-based immunity wanes further. "With the Omicron variant, after the first booster dose, the protection starts to really drop off by about six months," he said.

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Top Virus Expert Warns Boosted People to Do This "As Soon as" They Can - Best Life

UST Strengthens Presence in the Health Tech Sector with Strategic Investment in Israeli SaaS Start-up Well-Beat – PR Newswire

Innovative new digital patient engagement solution allows for dynamic personalization and improved outcomes

TEL AVIV, Israel and ALISO VIEJO, Calif., July 6, 2022 /PRNewswire/ --UST,a leading digital transformation solutions company has announced that it will strengthen its presence in the healthcare technology market with a strategic investment inWell-Beat, a pioneering Israeli start-up that adds a human touch to healthcare through patient-centered behavioral AI. The investment in Well-Beat is the latest example of UST accelerating the adoption of emerging tech solutions in healthcare and transforming lives through the power of technology.

By investing in Well-Beat, UST is helping to bring one of the success stories of the innovative Israel start-up tech ecosystem to a wider global market. Combining the size and scale of UST with the agility of Well-Beat, this strategic investment will put digital transformation to work for patients at a time when healthcare delivery systems are strained and intelligent patient engagement is increasingly critical.

"At UST, we work with academia, innovators and entrepreneurs from across the global start-up community to bring the very best transformational solutions to market. However, we only directly invest in less than one percent of our partnerships those that represent the best of the best in emerging health tech. Well-Beat has earned its reputation as a successful innovator in the rapidly evolving HealthTech space, and we're thrilled to offer a platform which empowers them to continue their groundbreaking work," said Sunil Kanchi, Chief Information Officer & Chief Investment Officer, UST.

UST, together with Well-Beat, created a first-of-its-kind digital patient engagement Software as a Service (SaaS) solution that dynamically adapts to each individual patient over time, delivers personalized conversational guidelines to the clinician at the point of care, offers customized prompts that are shaped by the profile of each individual patient and helps deliver direct and indirect behaviorally guided motivational nudges to patients based on over 1,400 unique factors.

Utilizing information gathered through medical records, connected devices and short patient surveys, Well-Beat's technology dynamically adapts patient communication to provide intelligent interventions and highly customized experiences. Furthermore, this latest patient engagement solution designed in collaboration with UST is able to seamlessly operate within the existing health tech ecosystem of any healthcare delivery organization. This includes working with electronic health record (EHR) systems, public cloud providers, patient registries and existing wellness or care management applications.

Capable of operating without mandating changes to existing workflows or onboarding to a new platform, this dynamically personalized digital patient engagement solution is designed to help healthcare organizations achieve greater returns on their existing IT investments as well as achieve higher response rates and better engagement through their existing communication channels.

"As healthcare transitions outside the four walls of the hospital, the behavioral AI powered patient engagement solution that UST has built with Well-Beat enables healthcare organizations to effectively engage high-risk patients - resulting in improved care outcomes," saidRaj Gorla, Chief Executive Officer, UST ContineoHealth.

"Well-Beat is excited about strengthening our relationship with UST. The increased collaboration and ability to leverage UST's vast experience and resources will help us continue to deliver personalized patient outreach," saidRavit Ram Bar-Dea, Co-Founder & Chief Executive Officer, Well-Beat. "We feel that UST's leadership and expertise across the entire healthcare technology ecosystem and continuum is tailor-made to complement our strengths as we look to bring new products to market."

About UST:

For more than 22 years, UST has worked side by side with the world's best companies to make a real impact through transformation. Powered by technology, inspired by people, and led by our purpose, we partner with our clients from design to operation. Through our nimble approach, we identify their core challenges, and craft disruptive solutions that bring their vision to life. With deep domain expertise and a future-proof philosophy, we embed innovation and agility into our clients' organizationsdelivering measurable value and lasting change across industries, and around the world. Together, with over 30,000 employees in 30+ countries, we build for boundless impacttouching billions of lives in the process. Visit us atwww.UST.com

About Well-Beat:

Well-Beat providesa next-generation patient behavioral change solution, based on human behavior, expert understanding and proprietary data-driven technology. At its core, the solution empowers healthcare providers and organizations to dramatically increase patient engagement and treatment regime adherence.

The company's mission is to bring humanity to healthcare through raising the level of engagement and personal responsibility of patients to their health and wellness regime. By incorporating Well-Beat insights into their daily practices, healthcare providers can generate more effective face-to-face meetings with patients, along with digital intelligent interventions, to ultimately provide the most suitable wellness program and approach for each patient. Through adjustment of personalized interactions to every patient, Well-Beat enables healthcare organizations to boost their operational efficiency, increase revenues and reduce long-term healthcare costs, while maintaining the level of treatment. Learn more athttps://www.well-beat.com/

Media Contacts, UST:

Tinu Cherian Abraham+1 (949) 415-9857

Merrick Laravea+1 (949) 416-6212

Neha Misri+91-9972631264[emailprotected]

Media Contacts, U.S.:

S&C PR+1-646.941.9139[emailprotected]

Media Contacts, Australia:

Team Lewis[emailprotected]

Media Contacts, U.K.:

FTI Consulting[emailprotected]

Logo: https://mma.prnewswire.com/media/1422658/UST_Logo.jpg

SOURCE UST

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UST Strengthens Presence in the Health Tech Sector with Strategic Investment in Israeli SaaS Start-up Well-Beat - PR Newswire

Algorithm claims to predict crime in U.S. cities before it happens – SecurityInfoWatch

A new computer algorithm can now forecast crime in a big city near you apparently.

The algorithm, which was formulated by social scientists at the University of Chicago and touts 90% accuracy, divides cities into 1,000-square-foot tiles, according to a study published in Nature Human Behavior. Researchers used historical data on violent crimes and property crimes from Chicago to test the model, which detects patterns over time in these tiled areas and tries to predict future events. It performed just as well using data from other big cities, including Atlanta, Los Angeles and Philadelphia, the study showed.

The new tool contrasts with previous models for prediction, which depict crime as emerging from hotspots that spread to surrounding areas. Such an approach tends to miss the complex social environment of cities, as well as the nuanced relationship between crime and the effects of police enforcement, thus leaving room for bias, according to the report.

It is hard to argue that bias isnt there when people sit down and determine which patterns they will look at to predict crime because these patterns, by themselves, dont mean anything, said Ishanu Chattopadhyay, Assistant Professor of Medicine at the University of Chicago and senior author of the study. But now, you can ask the algorithm complex questions like: What happens to the rate of violent crime if property crimes go up?

But Emily M. Bender, professor of linguistics at the University of Washington, said in a series of tweets that the focus should be on targeting underlying inequities rather than on predictive policing, while also noting that the research appears to ignore securities fraud or environmental crimes.

And other crime prediction models previously used by law enforcers have been found to erroneously target certain people based on a narrower set of factors. In 2012, the Chicago Police Department along with academic researchers implemented the Crime and Victimization Risk Model that produced a list of so-called strategic subjects, or potential victims and perpetrators of shooting incidents determined by factors such as age and arrest history.

The model assigned a score that determined how urgently people on the list needed to be monitored, and a higher score meant they were more likely to be perceived as either a potential victim or perpetrator of a gun crime.

But after a lengthy legal battle, a Chicago Sun-Times investigation revealed in 2017 that nearly half of the people identified by the model as potential perpetrators had never been charged with illegal gun possession, while 13% had never been charged with a serious offense. In contrast, the tool designed by Chattopadhyay and his colleagues uses hundreds of thousands of sociological patterns to figure out the risk of crime at a particular time and space.

The study, Event-level Prediction of Urban Crime Reveals Signature of Enforcement Bias in U.S. Cities, was supported by the Defense Advanced Research Projects Agency and the Neubauer Collegium for Culture and Society.

___

2022 Bloomberg L.P. Visitbloomberg.com.Distributed by Tribune Content Agency, LLC.

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Pet of the Week: Smoot | Pet of the Week | thedaonline.com – The Daily Athenaeum – thedaonline

Meet Smoot! Smoot is a cute bearded dragon lizard who does a great rock impersonation. He loves to sit on his log under his heat lamp and observe his domain (the house and/or off the balcony). Nothing phases him... he is super chill and a great buddy for long car rides. Smoot is more judgmental of human behavior than any cat, always with his nose in the air. When he is feeling particularly energetic, all he wants to do is bolt around the house and/or outside while on his leash. Each time he does a spurt of running around somewhere, Smoot looks back at me to see if I'm still there. He loves to eat live bugs and the choicest fruits, but hates eating his vegetables. Smoot doesn't do any tricks, but he is (mostly) potty-trained, and everyone loves to watch him eat because he looks like a dinosaur. His favorite treat is bananas- he goes bananas for bananas. He also likes eating clover flowers and the bees that pollinate them.

Submitted by Catherine Smith.

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CISO priorities for the second half of 2022 – Cybersecurity Dive

Sometimes sticking to the basics is the best approach. Thats what CISOs say they will focus on as their priorities in the second half of 2022.

Regardless of everything else happening in the world, and all the latest shiny baubles in security, it's important to maintain the basics, said Jon Davis, CISO at Oomnitza.

Those basics include single sign-on, endpoint protection, proper patching, security awareness and training, encryption, and multifactor authentication.

The reason for making standard security best practices a priority is simple: when you take the easy stuff for granted, Davis said, it opens the door for risks.

In companies with 50-1,000 employees, CISOs considered security hygiene the most critical security priority according to a study by Forgepoint Capital.

The priority is born of resource constraints. These organizations typically lack the budgets to build layers of backups or failovers, according to the report.

This differed from the smallest organizations, which emphasize talent development and social engineering awareness. Enterprise-scale organizations have prioritized incident response and digital transformation.

Humans in SMBs play a much more vital role in the organizations overall security posture than they do in the enterprise. Smaller companies dont have the budgets available for some of the more sophisticated security systems that large companies bring in.

That puts the onus on human behavior to keep the network secure. That includes putting more emphasis on security hygiene, such as cyber awareness education to avoid phishing attacks, or encouraging regular use of MFA and better password management.

Cybersecurity leaders, like all business leaders, want to tackle priorities with an eye toward cost-saving measures. Meanwhile the threat landscape is constantly changing.

Right now, my team and I are sticking to basics and working to advance security without having to make more significant investments or add tooling, said Ryan Davis, CISO at NS1.

As the year progresses, we look at our roadmap about where the business operates and what is achievable given the overall economic climate, Davis said.

As the world continues to adjust to life with COVID-19, more companies are requiring their employees to return to the office, at least part time.

The return dates for many of the largest organizations have been fluid, shifting as positive cases rise and fall. Securing the hybrid workforce is an issue that CISOs are prioritizing, especially as they see this as a long-term, if not permanent, work model.

While many companies are turning to zero trust as a way to offer security for a hybrid workforce, Jason Lee, CISO at Zoom, admitted there is no one-true definition of zero trust. So CISOs are charged with finding the zero trust solution that will work for them.

Lees approach is to protect the person and their devices, no matter where they are. Its an end user security strategy that I want to reinforce, said Lee.

In tandem, one of Lees priorities as a CISO is to come up with ways to better enable his business to work in this new environment.

One security solution he is pursuing is getting rid of passwords. No one likes passwords, and they open up the company to too many risks. Lees favorite approach is to leverage a hard token combined with a biometric, which will offer a secure MFA option (and gives users no choice but to use a second authentication tool) no matter where the user is located.

More than 60% of security leaders dont believe their efforts are fully supported by their organizations board of directors, according to research by Encore. The same study also found that C-suite leadership doesnt like to talk about cybersecurity until a data breach occurs. Bringing this leadership on board with cybersecurity issues is a top priority for CISOs as 2022 continues.

The good news, said Davis, is that leadership is being very responsive to security findings and prioritizing them appropriately. They are investing wisely into security and security products.

The government might be pushing this relationship building higher on the priority list. An Executive Order from the Biden administration directs government agencies and all organizations to improve information sharing and take steps to become more cyber resilient. This will require better communication between leadership and CISOs.

At Zoom, Lee is already working on this priority. His company has formed a cyber committee within the board. Lee engages with this committee with a 90-minute meeting quarterly and has regular ad hoc meetings to discuss the latest threats and other security-related concerns.

Having security priority goals may help CISOs plan their strategies, but if everyone in the company doesnt buy in, they likely wont succeed. Thats why encouraging a proactive partnership for company-wide security is a top goal for Davis.

To achieve this goal, communication with staff may need to be reframed as security needs your help to succeed rather than security is here to stop you from making mistakes.

This kind of communication is critical to make sure everyone in the company understands their role in achieving our security goals, said Davis.

The goal of security priorities is to protect the business from risk. CISOs may set the priorities, but it is up to everyone, from the board of directors to the front-desk receptionist, to make sure those priorities are achieved to meet the No. 1 goal: a successful business.

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CISO priorities for the second half of 2022 - Cybersecurity Dive

Public awareness campaigns appear to lessen human-caused fires in Utah – The Daily Universe – Universe.byu.edu

A human-caused wildfire burns on the mountains in Centerville on July 4. State officials hope to limit human-caused fires through public awareness campaigns. (Centerville Police Department via Facebook)

Utahns, it appears, are on fire in the sense theyre doing a great job making sure their state isnt.

Despite extreme drought, state fire officials are optimistic about how Utahs wildfire season is shaping up this summer and it may be thanks to public awareness campaigns.

After a record-breaking year of wildfires in 2020, the Utah Division of Forestry, Fire and State Lands launched Fire Sense to combat human-caused fires, which accounted for most of the fires in 2020. In 2021 Utah had 922 fewer human-caused fires.

Karl Hunt from Forestry, Fire and State Lands said the organization has seen a 50% decrease in human-caused fires this year. Hunt credits Fire Sense, a public awareness campaign focused on preventing human-caused fires. Thanks to that public awareness, Hunt said this years wildfire numbers are still trending downward. Fire experts and professionals have a positive outlook to support these numbers.

It seems to me that its been working, said battalion chief at Provo fire station 21 Crag Olson about public awareness campaigns like Fire Sense. Ive seen less in the last year or two than in previous years, I think people are being more cautious.

State Fire Marshal Ted Black agreed. I think all in all the citizens of Utah have stepped up and are trying to be safe, he said.

This year to date, Hunt said Utah has had 384 wildfires which have burned 6,000 acres. Around 250 of those fires are human-caused. Thats a number that is always up there for the cause of wildfires, he said.

Campaigns such as Hot Rod, Hot Sparks, Happy Campers Douse Fires and Ready, Aim No Fire promote awareness for common culprits of wildfires: cars, campers and even guns.

Olson said the Fourth of July weekend proved public behavior is changing for the better. I was pleasantly surprised at how few fire calls we had, he said. People did a lot better job.

The state often uses fire as a land management tool but it can quickly become a problem when unplanned and unnatural fires start popping up.

We can use fire to increase the health of the forest, Black said. But if all of our resources are out on fires we cant do that.

Thanks to a significant reduction in the amount of human-caused fires, Black said the Forest Service and other divisions of the Department of Natural Resources are able to put resources toward fighting more natural fires this year.

The resource drain from fighting human-caused fires is a potential issue with most of Utah in an extreme drought. Black said so far, the drought has primarily affected how fast and how far fires burn but could become a bigger issue if water reserves start to run out.

Weve had plenty of water to fight fire, but if we start having lakes go dry then thats going to be an issue, he said.

In the weeks before July 24th, another holiday which usually involves fireworks, Olson said dry weather could make celebrations dangerous if people arent careful.

If we dont get any more rain between now and then well be a little worse off, he said.

As the summer continues to get hotter and drier, the responsibility for reducing human-caused fires falls to every Utahn camping, lighting fireworks and even driving.

We can make a significant difference in the health of our forest, in reducing loss, unnecessary loss due to fire, if we just be careful,Olson said.

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Public awareness campaigns appear to lessen human-caused fires in Utah - The Daily Universe - Universe.byu.edu

The Hidden Governance in AI – The Regulatory Review

Measurement modeling could further the governments understanding of AI policymaking tools.

Governments are increasingly using artificial intelligence (AI) systems to support policymaking, deliver public services, and manage internal people and processes. AI systems in public-facing services range from predictive machine-learning systems used in fraud and benefit determinations to chatbots used to communicate with the public about their rights and obligations across a range of settings.

The integration of AI into agency decision-making processes that affect the publics rights poses unique challenges for agencies.

System design decisions about training data, model design, thresholds, and interface design can set policythereby affecting the publics rights. Yet today many agencies acquire AI systems through a procurement process that lacks opportunities for public input on system design choices that embed policy, limits agencies access to information necessary for meaningful assessment, and lacks validation and other processes for rooting out biases that may unfairly, and at times illegally, affect the public.

Even where agencies develop AI systems in house, it is unclear given the lack of publicly available documentation whether the policy relevant design choices are identified and subject to rigorous internal scrutiny, and there are only a few examples of such policy relevant design choices being subject to public vetting.

AI systems can be opaque, making it difficult to fully understand the logic and processes underlying an output, therefore making it difficult to meet obligations that attach to individual decisions. Furthermore, automation bias and the interfaces and policies that shape agency use of AI tools can turn systems intended as decision support into decision displacement.

Some governments have begun to grapple with the use of AI systems in public service delivery, providing guidance to agencies about how to approach the embedded policy choices within AI.

Canada, for example, adopted new regulations to ensure agency use of AI in service delivery is compatible with core administrative law principles including transparency, rationality, accountability, and procedural fairness. In April 2021, the European Commission unveiled a proposed Artificial Intelligence Act which is currently wending its way through the complex EU trilogue process. If adopted, the European law will, among other things, set standards and impose an assessment process on AI systems used by governments to allocate public benefits or affect fundamental rights.

These efforts are important. Nevertheless, building the capacity of administrative agencies to identify technical choices that are policyand therefore ought to be subject to the technocratic and democratic requirements of administrative law regardless of whether AI systems are built or boughtrequires tools and guidance to assist with assessments of data suitability, model design choices, validation and monitoring techniques, and additional agency expertise.

There is a growing set of tools and methods for AI system documentation. Used at appropriate times in the development or procurement of an AI system, these tools can support collaborative interrogation of AI systems by domain experts and system designers.

One such method is measurement modeling. Part of routine practice in the quantitative social sciences, measurement modeling is the process of developing a statistical model that links unobservable theoretical constructs (what we would like to model) to data about the world (what we are left with). We have argued elsewhere that measurement modeling provides a useful framework for understanding theoretical constructs such as fairness in computational systems, including AI systems.

Here, we explain how measurement modeling, which requires clarifying the theoretical constructs to be measured and their operationalization, can assist agencies to understand the implications of AI systems, design models that reflect domain specific knowledge, and identify discrete design choices that should be subject to public scrutiny.

The measurement modeling process makes the assumptions that are baked into models explicit. Too often, the assumptions behind models are not clearly stated, making it difficult to identify how and why systems do not work as intended.

But these assumptions describe what is being measured by the systemwhat the domain-specific understanding of the system is, versus what is actually being implemented. This approach provides a key opportunity for domain experts to inform technical experts about the reasonableness of assumptionsboth assumptions about which intended domain specific understanding of a concept should be used, and assumptions about how that concept is being implemented.

Careful attention to the operationalization of the selected concept offers an additional opportunity to surface mismatches between technical and domain experts assumptions about the meaning of observable attributes used by the model.

The specific tools used to test measurement modeling assumptions are reliability and construct validity. Broadly, this entails asking questions such as: What does an assumption mean? Does the assumption make sense? Does it work and in the way we expect?

An easily overlooked yet crucial aspect of validity is consequential validity, which captures the understanding that defining a measure changes its meaning. This phenomenon includes Goodharts Law, which holds that once a measure is a target, it ceases to be a good measure. In other words, does putting forward a measurement change how we understand the system?

As Ken Alder has written, measures are more than a creation of society, they create society. This means that any evaluation of a measurement model cannot occur in isolation. As with policymaking more broadly, effectiveness must be considered in the context of how a model will then be used.

AI systems used to allocate benefits and services assign scores for purposes such as predicting a teachers or schools quality, ranking the best nursing homes for clinical care, and determining eligibility for social support programs. Those assigned scores can be used as inputs into a broader decision-making process, such as to allocate resources or decide which teachers to fire.

Consider SASs Education Value-Added Assessment System (EVAAS), a standardized tool that claims to measure teacher quality and school district quality. Measurement modeling can help break down what EVAAS is doingthat is, what policies are being enforced, what values are being encoded, and what harms may come to pass as a result.

The EVAAS tool operationalizes the construct of teacher quality from a range of abstract ideals into a specific idea, a latent force that can be measured from differences in student test scores across years. To ensure that a measurement model is capturing what is intended, the designers of specific EVAAS tools need to consider the validity of the design choices involved.

For instance, does the operationalization of teacher quality fully capture the ideal (content validity) or match other agreed upon measures (convergent validity)? Cathy ONeil described examples where EVAAS scores were misaligned with teachers receiving teaching awards and support from the community.

We can further ask: Are the EVAAS teacher scores reliable across years? Again, ONeil has pointed to examples where a teacher could go from scoring six out of 100 to 96 out of 100 within one year. Teacher scores can further penalize students near the lower thresholds. Under-resourced school districts systematically result in lower teacher quality scores, which are much more likely a reflection of other social phenomena affecting the scores than teachers themselves (discriminant validity).

In addition, EVAAS tools literally encourage teaching to the testthat is, pedagogy that emphasizes test performanceat the expense of other educational priorities.

But even AI tools used for discovery are implicitly assigning scores, which are used to allocate agency attentionyet another decision.

Consider a federal government-wide comment analysis tool that surfaces relevant regulatory comments, identifies novel information and suppresses duplicate comments. What are those tools doing? Sorting comments by relevancebut that requires finding an implicit ranking, based on some understanding and measurement of what relevance means.

A measurement of relevance depends on defining or operationalizing relevance. So any system that sorts by relevance depends on this measurements. And these measurements are used to guide users action about what comments should be followed up on, or safely ignored, with what urgency, and so on.

All this means that the definition and operationalization of relevanceor any other conceptis governance. Even though one persons understanding of what is relevant might differ from another persons, there is now one understanding of relevance embedded in the AI modelout of sight and upstream. Human decisions that once informed policy are now tasks defined through design in upstream processes, possibly by third-party vendors rather than expert agency staff.

Previously visible and contestable decisions are now masked, and administrators have given this decision-making away. Unless of course, they have tools that help them retain it. That is where measurement modeling comes in.

Although even skilled experts cannot fully understand complex AI systems through code review, measurement modeling provides a way to clarify design goals, concepts to be measured, and their operationalization. Measurement models can facilitate the collaboration between technical and domain experts necessary for AI systems that reflect agency knowledge and policy.

The rigor imposed by measurement modeling is essential given that important social and political values that must guide agency action, such as fairness, are often ambiguous and contested and therefore exceedingly complex to operationalize. Moreover, the data that systems train and run on is imbued with historical biases, which makes choices about mappings between concepts and observable facts about the world fraught with possibilities for entrenching undesirable aspects of the past.

When the measurement modeling process surfaces the need to formalize concepts that are under-specified in law, it alerts agencies to latent policy choices that must be subject not only to appropriate expert judgment but to the political visibility that is necessary for the legitimate adoption of algorithmic systems.

Whether an agency is developing the AI system or procuring it, there are a range of methods for bringing the knowledge of outside experts and the general public into the deliberation about system design. These include notice-and-comment processes, more consultative processes, staged processes of expert review and public feedback, and co-design exercises. Measurement modeling can be used within them all.

Issues warranting public participation can include decisions about the specific definition of a concept to be modeled as well as its operationalization. For example, fairness has multiple context-dependent, and sometimes even conflicting, theoretical definitions and each definition is capable of different operationalizations.

Existing jurisprudence on the setting of formulas and numerical cutoffs, and the choices underlying methodologies, provides useful guidance for identifying aspects of AI systems that warrant public input. Agency decisions that translate ambiguous concepts such as what is classified as appropriate into a fixed number or establish preferences for false negatives or positives are clear candidates.

The introduction of AI systems into processes that affect the rights of members of the public demands urgent attention. Agencies need new ways to ensure that policy choices embedded in AI systems are developed through processes that satisfy administrative laws technocratic demands that policy decisions be the product of reasoned justifications informed by expertise.

Agencies also need guidance about how to adhere to transparency, reason giving, and nondiscrimination requirements when individual determinations are informed by AI-driven systems. Agencies also need new experts and new tools to validate and monitor AI systems to protect against poor or even illegal outcomes produced by forces ranging from automation bias, model drift, and strategic human behavior.

Without new approaches, the introduction of AI systems will inappropriately deny and award benefits and services to the public, diminish confidence in governments ability to use technical tools appropriately, and ultimately undermine the legitimacy of agencies and the market for AI tools more broadly.

Measurement modeling offers agencies and the public an opportunity to collectively shape AI tools before they shape society. It can help agencies clarify and justify the assumptions behind models they choose, expose and vet them with the public, and ensure that they are appropriately validated.

Abigail Z. Jacobs is an assistant professor of information and of complex systems at the University of Michigan.

This essay is part of a nine-part series entitledArtificial Intelligence and Procurement.

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The Hidden Governance in AI - The Regulatory Review