Physiology

Op-Ed: Central Bucks should rethink Growth & Development lesson format – The Intelligencer

By Taura Kilroy| The Intelligencer

Last year, the Central Bucks School District offered the following Growth & Development lesson options: girls lesson, boys lesson, private viewing of materials or opt out.

When a transgender or non-binary student asked if they could attend the single-sex lesson of their choosing, they were told that they must learn the lesson that coincides with their physical form and not their gender identity.

This, at its core, isnt necessarily wrong. It is very important to not skip the content that pertains to ones personal organs. There is a strong case to be made that our LGBTQ+ population of students would benefit from receiving both lesson contents. But it is a sensitive topic and needs to be handled with sensitivity. The district needs to take a closer look at its policy and offerings. The way we approach this lesson needs an update to fit our ever-changing student body population.

I believe that our children should be given the option to choose the safest and most comfortable learning environment for their personal needs. What we need to do is ensure that there are enough options to accomplish the learning objective and also respect each choice.

So if a female-born student says they prefer a girls-only lesson, we need to respect that and give them a lesson with only students with the same physiology. Now if one of those students is born female and identifies as a male and this is common knowledge, they belong there. They are 100% welcome and included. And I will go far out of my way to make it known that we accept them and they deserve to be here just as much as the other female organ students in the room. The way I approach this encourages acceptance of differences.

So let's look at a more reasonable list of offerings. I would suggest:

Coed viewing of the educational video and then break-out groups for Q&A. For the breakout groups offer a coed option with one male and one female instructor, plus female only and male only options.

Private viewing of the video followed by a Q&A with a safe adult.

An opt-out option with a parent's signature that clearly states that the parent is expected to cover the topic in some form. This form would include checkboxes with reasoning for opting out and their intended method of delivery of information.

For the opt-out version, I suggest parents can check two different boxes.

1.) They can handle this topic privately at home and use a packet provided by the school as an educational guide. I would consider a follow-up call to check in and ask how it went. Ask if there was anything that they felt they didnt know how to answer that you could offer assistance with. This shows that you care and that you are holding them to their promise. It is protecting the childs right to information and promoting an encouraging environment.

2.) They can speak with a medical professional to better address specific physical needs. This option is not just reasonable for trans students but also for disabled students, students with other 504 MDE needs, or students with underlying health issues that none of us is aware of in their private life. Recognizing that some cases are very specific and may be better handled outside of the school with a professional specialist is also important.

The form should be set up with a space for the student to select their preferred lesson style first and then sent home for the parent to view and discuss which option the parent would prefer. They can change their choice at home but I believe the child's choice should be selected first so that they feel heard. The parent then signs off and returns the permission slip.

These options cover a wider variety of individual needs. The companies that produce these educational materials provide three versions of the material. They always produce both single-sex videos and a coed video of age appropriate material.

By ensuring that all students view the coed video we are sure they are all getting the same basic content. Allowing the students to choose their peer group for the Q&A is protecting their rights to privacy and providing them with options for a safe and caring environment that fits their needs.

I think these offerings protect our students' right to privacy and create a more conducive environment for learning, acceptance, sensitivity, and safety.

Taura Kilroy lives in Chalfont and is the mother of two elementary school students in the Central Bucks School District. She also 12 years experience as an Elementary Health & PE Teacher in Great Valley School District in Delaware County.

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Op-Ed: Central Bucks should rethink Growth & Development lesson format - The Intelligencer

Physiology

Brewing with Hemp: A Budding New Ingredient and a Different Kind of Haze – Craft Beer & Brewing

From esteemed brewing professional Ross Koenigs comes Brewing with Hemp: The Essential Guide, the latest release from Brewers Publications, now available at your favorite book retailers.

Brewing with Hemp by Ross Koenigs, the companion book to Brewing with Cannabis: Using THC and CBD in Beer by Keith Villa Ph.D., explores the Cannabis sativa plant from a brewers perspective, focusing on how hemp (which contains less than 0.3 percent THC), hemp flavors, and cannabinoids play in beer.

Koenigs leads readers through the history, legal considerations, physiology, and ecology of hemp, while helping professional brewers and homebrewers alike understand the science of cannabis and how to best utilize the popular plant in beer.

There are many cannabis consumers who also enjoy craft beer, and Im looking forward to sharing my vision for how hemp can be additive to an already innovative industry, said Koenigs. Through Brewing with Hemp: The Essential Guide, Ill not only take readers through the process and experimentation, but Ill also share recipes and tinctures and my experience of bringing these beers to market.

The second book in the cannabis series is perfect for homebrewers, professional brewers, enthusiasts, and appreciators of the hop plants dank cousin.

Brewing with Hemp is a book for a brewing and beverage industry audience; some hemp ingredients can be added to beer, but marijuana ingredients cannot be legally added. Learn more about the legal limitations, history of cannabis, and more with expertly researched chapters covering:

Order Brewing with Hemp: The Essential Guide directly from the publisher or your favorite independent bookseller.

Ross Koenigs is the owner of Second Dawn Brewing in Aurora, Colorado. Previously, he was the brewing innovations manager for New Belgium Brewing in Fort Collins, Colorado, where he spearheaded the research and development of using hemp in beer when New Belgium introduced The Hemperor HPA.

Brewers Publications supports the mission of the Brewers Association by publishing books of enduring value for amateur and professional brewers, as well as titles that promote understanding and appreciation of American craft beer. With more than 65 titles to choose from, Brewers Publications is the leading publisher of contemporary and relevant brewing literature for today's craft brewers, homebrewers, and beer enthusiasts.

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Brewing with Hemp: A Budding New Ingredient and a Different Kind of Haze - Craft Beer & Brewing

Physiology

ESIC Recruitment 2022: Check Posts, Eligibility and Walk-in Interview Details Here – StudyCafe

ESIC Recruitment 2022: Check Posts, Eligibility and Walk-in Interview Details Here

ESIC Recruitment 2022: Employees State Insurance Corporation (ESIC), Bengaluru has invited the Candidates with duly complete Applications and other documents Eligible for Appointment to the Posts of Senior Residents/Tutors (Anatomy/Physiology/Pharmacology/Forensic Medicine/Community Medicine) on 03-Years Contractual Basis. The Candidates fulfilling the Eligibility Criteria for the Post of Senior Resident(s) deem themselves Eligible for the Post, may fill up the Applications in the Specimen Application Proforma and report in the ESIC-Medical College Post-Graduate Institute of Medical Science and Research and Medical Hospital to attend Personal Interview and Document Verification. The Candidates may download the Specimen Application Format available on the Website.

There are 15 Vacancies for the Post of Senior Resident under different Branches mentioned in ESIC Recruitment 2022 *Note: Such Candidates who have already served under the Three-Years Senior Residency Scheme are NOT Eligible to reapply. The End Date for appearing in Walk-in Interviews befalls 26th August 2022.

ESIC Interview 2022: The ESIC Medical College PG Institute of Medical Science shall host on 26th August 2022 Walk-in Interviews for the Candidates within the ESIC Complex. The Candidates must carry with them duly completed Applications and other documents. The Candidates should carry with them the essential Documents while appearing for the Walk-in-Interview include, are Xerox of the Certificates and Documents; viz. i) Application Form, ii) 02 Most Recent Passport-size Photographs; iii) Matriculate Certificate (claiming the Date of Birth), iv) Masters (Post Graduation) Degree, PG Diploma; v) KMC/MCI Registration Certificate; vi) Caste-Community Certificate.

Service Tenure: Appointment to the Post of Senior Residents in ESIC Medical College and Post Graduate Institute of Medical Science and Research Bangalore (ESI-PGIMSR) Model College will remain for 03-Years under the Senior Residency Scheme. Such Candidates who have already served under Three-Years Senior Residency Scheme will NOT be considered Eligible for Re-appointment. However, those who already served for One Year will be appointed for only 02 Years.

Check the Details about ESIC Senior Resident/Tutors Recruitment 2022

Name of the Organization: Employees State Insurance Corporation: 15 Vacancies

Name of the Post: Senior Resident (Anatomy/Physiology/Pharmacology/Forensic Medicine/Community Medicine) on Contractual Basis (As On 26.08.2022)

Pay Emolument: Pay Band Level-11 of Rs.67700 Plus Other Allowances As Applicable under the Government of India.

01) Senior Resident (Anatomy): 03 Vacancies

02) Senior Resident (Physiology): 03 Vacancies

03) Senior Resident (Pharmacology): 03 Vacancies

04) Senior Resident (Forensic Medicine): 02 Vacancies

05) Senior Resident (Community Medicine): 04 Vacancies

Upper Age Limit: i) General Category Candidate should not exceed (Maximum) 45 Years.ii) Relaxation in Upper Age Limit for Reserved Community Candidates.

Educational Qualification: The Applicant should have in possession Post-Graduate Diploma/DNB/MD Or M.Sc. (Medical) in the concerned Specialty for Senior Resident.

Selection Process: Selection to the Post of Senior Resident will be based on the Candidates Performance in Walk-in-Interview coupled with Document Verification to the desired Eligibility Benchmark.

Service Tenure: Post-Selection Appointment to Senior Residents Tenure remains 03 Years. The Incumbent will have to deposit Non-Interest Rs. 1.25 Lac in favor of ESIC Fund A/c No.1)

Interview Details:

ESIC Medical College And PG Institute of Medical Science & Research and Model HospitalAcademic Block, Rajajinagar, Bangalore 560 010

1. Visit ESIC-MC PGIMSR Website http://www.esic.nic.in.

2. Download the Specimen Application Proforma and other Annexures. Take a Printout and Fill up the Typewritten Application,

Click Here to Read Employees State Insurance Corporations Official Notification-2022

Disclaimer: The Recruitment Information provided above is for informational purposes only. We do not provide any Recruitment guarantee. Recruitment is to be done as per the official recruitment process of the company or organization posted the recruitment Vacancy. We dont charge any fee for providing this Job Information. Neither the Author nor Studycafe nor its Affiliate(s) accepts any liabilities for any loss or damage of any kind arising out of any information in this article nor for any actions taken in reliance thereon.

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ESIC Recruitment 2022: Check Posts, Eligibility and Walk-in Interview Details Here - StudyCafe

Physiology

How to find the right athletics coach for you | PERFORMANCE – World Athletics

Finding the right athletics coach for you is important, ensuring they provide advice that fits your needs and lifestyle, and help to create a positive, sustainable relationship with the sport.

But how to go about it? Heres our quick guide on finding the right coach for you.

Different coaches will be valuable for different people, so finding a coach who matches your needs will help get the most out of your athletics journey.

Some coaches may foster a group with a focus on making sessions as fun as possible. These coaches can be great when first finding your way into the sport, encouraging you to learn its disciplines and make you want to keep coming back.

If part of the reason you are taking up athletics is for the social interactions it creates, these coaches may be the best place to start.

Other coaches may have more of a focus on the performance side of athletics and be more appropriate for those who feel they already have an understanding of the sport and want further guidance on particular aspects of their event.

For those doing multiple disciplines, some may even choose to have more than one coach, with specialists guiding them for jumps, sprints and throws, though there are multi-discipline coaches that focus on all the events.

These performance-focused coaches can take many different forms, from experienced coaches to former athletes as well as those with a science-focused physiology background. Think of what sort of advice you would see as valuable and select your coach accordingly.

To gain a sense of the types of sessions run by coaches, take a look on social media as well as on club and coach websites, or even ask if you can do a trial session.

Many national athletics federations have a list of qualifications available to coaches on their websites.

See if the coach you hope to work with has any of these, as it will be a good indicator of the experience they have gained.

As well as these qualifications, World Athletics offers aneLearning platform, which provides educational courses and webinars for people within the sport, including those in key stakeholder groups such as technical officials, coaches and medical professionals. Further information can be found here.

Like people in everyday life, coaches will have different personalities. Some people like working with enthusiastic and loud coaches, valuing the support and clear instructions. Others prefer a softly-softly approach, with less-frequent but nonetheless valuable feedback.

Think about what you require in a coach.Speak to current group members already guided by your potential coach to gauge their personality and contemplate whether that would work for you.

Ensuring you are both on the same page will create a more positive, long-lasting and sustainable relationship for athlete and coach.

Appraise yourself honestly and think about what sort of role you see athletics playing in your life. If family, work and other life commitments may affect your training, make sure you find a coach that understands that. Be honest and up front with that coach when it comes to how you see the relationship working.

A good indicator of this will be finding a coach who works with other athletes with a similar lifestyle to you, and a good way of finding this out will be heading down to the track and trying out a few sessions for yourself.

For tips on finding the right athletics club for you and getting into track running, check out the advice here.

George Mallett for World Athletics

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How to find the right athletics coach for you | PERFORMANCE - World Athletics

Physiology

A novel method for monitoring the ‘engine’ of pregnancy | Penn Today – Penn Today

A study published in Nature Biomedical Engineering details a novel method for imaging the placenta in pregnant patients as well as the results of a pilot clinical study. By combining optical measurements with ultrasound, the findings show how oxygen levels can be monitored noninvasively and provides a new way to generate a better understanding of this complex, crucial organ. This research was the result of a collaboration of the groups of the University of Pennsylvanias Arjun Yodh and Nadav Schwartz with colleagues from the Childrens Hospital of Philadelphia (CHOP) and was led by postdoc Lin Wang.

Schwartz describes the placenta as the engine of pregnancy, an organ that plays a crucial role in delivering nutrients and oxygen to the fetus. Placental dysfunction can lead to complications such as fetal growth restriction, preeclampsia, and stillbirth. To increase knowledge about this crucial organ, the National Institute of Child Health and Human Development launched the Human Placenta Project in 2014. One focus of the program is to develop tools to assess human placental structure and function in real time, including optical devices.

For three years, the researchers optimized the design of their instrument and tested it in preclinical settings. The process involved integrating optical fibers with ultrasound probes, exploring various ultrasound transducers, and improving the multimodal technology so that measurements were stable, accurate, and reproducible while collecting data at the bedside. The resulting instrumentation now enables researchers to study the anatomy of the placenta while also collecting detailed functional information about placenta blood flow and oxygenation, capabilities that existing commercially devices do not have, the researchers say.

Because the placenta is located far below the bodys surface, one of the key technical challenges addressed by Wang, a postdoc in Yodhs lab, was reducing background noise in the opto-electronic system. Light is scattered and absorbed when it travels through thick tissues, Yodh says, and the key for success was to reduce background interference so that the small amount of light that penetrates deep into the placenta and then returns is still large enough for a high-quality measurement.

Were sending a light signal that goes through the same deep tissues as the ultrasound. The extremely small amount of light that returns to the surface probe is then used to accurately assess tissue properties, which is only possible with very stable lasers, optics, and detectors, says Yodh. Lin had to overcome many barriers to improve the signal-to-noise ratio to the point where we trusted our data.

Notably, the paper also describes the results of a pilot study where 24 pregnant patients in their third trimester were given supplemental oxygen for a short time period, creating placental hyperoxia. Using the device, the team collected measurements of the placentas oxygenated and deoxygenated blood concentrations before and during hyperoxia; the results demonstrated that the device could be used to study placental function in real time. The research also provided new insights into the relationship between blood flow and maternal vascular malperfusion, which occurs when blood flow into the placenta is impeded.

Not only do we show that oxygen levels go up when you give the mom oxygen, but when we analyze the data, both for clinical outcomes and pathology, patients with maternal vascular malperfusion did not have as much of an increase in oxygen compared to patients with normal placentas, says Schwartz. What was exciting is that, not only did we get an instrument to probe deeper than commercial devices, but we also obtained an early signal that hyperoxygenation experiments can differentiate a healthy placenta from a diseased placenta.

While the device is still in development, the researchers are currently refining their instrument to make it more user-friendly and to allow it to collect data faster. The team is also currently working on larger studies, including recently data from patients during their second trimester, and they are also interested in studying different regions of the placenta. From an instrumentation perspective, we want to make the operation more user-friendly, and then we want to carry out more clinical studies, Wang says about the future of this work. We have lots of interesting ideas.

And because there are many unanswered clinical questions about the placenta, for Schwartz the biggest potential of this work is in providing a way to start answering those questions. Without being able to study the placenta directly, we are relying on very indirect science, he says. This is a tool that helps us study the underlying physiology of pregnancy so we can more strategically study interventions that can help support good pregnancy outcomes.

The authors are Lin Wang, Jeffrey M. Cochran, Kenneth Abramson, Lian He, Venki Kavuri, Samuel Parry, Arjun G. Yodh, and Nadav Schwartz from Penn; Tiffany Ko, Wesley B. Baker, and Rebecca L. Linn from the Childrens Hospital of Philadelphia, and David R. Busch, previously a research associate at Penn and now at the University of Texas Southwestern Medical School.

Arjun Yodh is the James M. Skinner Professor of Science in the Department of Physics and Astronomy in the School of Arts & Sciences at the University of Pennsylvania.

Nadav Schwartz is an Associate Professor in the Department of Obstetrics and Gynecology in Penns Perelman School of Medicine.

Lin Wang is a postdoc in the Department of Physics and Astronomy in Penns School of Arts & Sciences.

This research was supported by National Institutes of Health grants F31HD085731, R01NS113945, R01NS060653, P41EB015893, P41EB015893, T32HL007915, and U01HD087180.

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A novel method for monitoring the 'engine' of pregnancy | Penn Today - Penn Today

Cell Biology

Illumina Supports Enhanced Genomics-Enabled Discovery and Training Programs at UC San Diego – University of California San Diego

New laboratory automation technology will advance marine biomedical research, preparing students for biotech workforce

The Illumina Laboratory in Scholander Hall is one of two new automation Hubbs on the Scripps Oceanography campus. Photos by Erik Jepsen/University Communications.

Scripps Institution of Oceanography at the University of California San Diego announced today that Illumina, a global leader in development and application of genomic technology to improve human and environmental health, has provided researchers at the Center for Marine Biotechnology and Biomedicine at Scripps new scientific equipment to build genomics and laboratory automation-enabled discovery and training programs. Additionally, the Illumina Corporate Foundation donated $973,000 for additional materials to bring the equipment into operation and set up two laboratories on the Scripps Oceanography campus.

The Center for Marine Biotechnology and Biomedicine (CMBB) at Scripps focuses on research at the intersection of ocean sciences and human health. This support from Illumina will be used in the development of an automation hub to enable advanced synthetic biology, marine drug compound library curation, microbiome science, marine model organism cell biology and more. It will also become a training tool for students as they prepare to enter the biotechnology and genomics workforce.

Illumina is dedicated to creating opportunities to invite innovation and work collaboratively to unlock the potential of genomics, said Ashley Van Zeeland, vice president and head of Open Innovation at Illumina. With this equipment transfer, we hope to enable the acceleration of discoveries in marine biology that could improve both human and planetary health. We are also thrilled to get this automated technology into the hands of future scientists who will drive the next era of discovery at a scale we can hardly imagine today.

In the Illumina Lab in Scholander Hall, PhD student Kayla Wilson operates a new bulk reagent dispenser, which can rapidly fill well plates with two different liquids. Postdoctoral scholar Timothy Fallon programs a liquid handling robot.

This technology provided to Scripps Oceanography includes high-throughput screening equipment such as robotic liquid handlers, imaging processing stations, robotic arms for microplate handling, and more. The equipment will allow researchers to screen thousands of cells a day, observe protein evolutions, analyze DNA isolation for microbiome studies, characterize gene expression patterns during early development, determine the effects of toxicants on developing embryos, and more. High-capacity computing equipment and a new liquid-chromatography mass spectrometry system that enables rapid analysis was also included.

The two new laboratories will be operated by professors Bradley Moore and Amro Hamdoun. Moore is a marine chemical biologist and director of CMBB whose lab is focused on the discovery of drug leads and toxins from marine organisms and the development of biosynthetic cellular factories to make sustainable products. Hamdoun is a marine biologist working to generate new, genetically-enabled marine cell biological model organisms useful for ongoing biomedical research. Hamdoun Lab graduate students Yoon Lee, Evan Tjeerdema, and Nathan Chang are also examining how different environmental stressors and harmful chemicalssuch as persistent organic pollutants like flame retardants and legacy pesticidesinteract during early life stages of embryo development in sea urchins. These interactions have implications for understanding the health impacts of in utero chemical exposures for humans.

The use of genomics can aid the two Scripps labs in understanding chemical interactions between microorganisms and their chemical signals, thus enabling researchers to better understand human health and develop bio-based sustainable solutions.

A pipetting robot dilutes samples into a plate for imaging in the Illumina Laboratory in Hubbs Hall.

Much of this research requires individually analyzing hundreds of samples, a process that was pretty labor intensive and slow, said Hamdoun. This new equipment will allow researchers in his lab to image and process thousands of samples a week when they were previously limited to a couple hundred. The potential gains from this are substantial, and Hamdoun emphasizes that these tools will supercharge our work over the next few years. In particular, the new image processing station will allow the team to examine subcellular structures and expression patterns, allowing them to better understand how genes are patterned during embryonic development and how they change throughout this development.

Moore predicts that this equipment will allow for the discovery of even more new molecules with life-saving potential.

This support allows us to dream big, added Moore. It allows us to do experiments that we thought were going to be too difficult, too hard, or too expensive to do by allowing us to miniaturize the way we look at things, and be able to access so many more samples than we can do right now.

The equipment will also provide immense training opportunities for students, giving them experience in genomics and laboratory automation that is critical in todays life science and biotechnology workforce. The life science industry in San Diego is significant, supporting 175,000 jobs and generating about $41 billion in economic activity, according to Biocom, the California life sciences trade group.

We are thrilled to create opportunities that connect local university scientists to industry, said Sharon Vidal, senior director of corporate social responsibility at Illumina. Preparing our future workforce with access to the latest innovation in life science is a win win for all.

Moore Lab National Institutes of Health (NIH) Postdoctoral Fellow Timothy Fallon agrees.

From left to right, Hamdoun Lab graduate students Yoon Lee, Nathan Chang, and Evan Tjeerdema work in the new Illumina Laboratory in Hubbs Hall.

Todays students need to be familiar with solving biological problems at these huge scales, and that simply cant be done without the use of laboratory automation and big data experimental design and informatics, said Fallon, who helped spearhead the effort to develop the automation hub. This is why the support is so exciting. It allows us to build the facilities and coursework to both teach these cutting-edge topics, and to apply them in our research.

Hamdoun says that a significant portion of Scripps students end up pursuing careers in biotech, and these new systems will enable them to gain exposure to equipment that is commonplace in the industry much earlier in their education.

This allows students to come out of Scripps and UC San Diego better equipped to work and compete in the modern life sciences industry, says Hamdoun. This has always been very central to usto best prepare our students for positions in industry and increase the diversity of people working outside of academia.

For Moore Lab NIH Postdoctoral Fellow April Lukowski, the robotic liquid handlers are increasing her efficiency in X-ray crystallography, where she works to crystallize proteins to understand their structures. This process informs scientists how the proteins work so they can modify them into something that might be useful in drug development or manufacturing. She has gone from spending two hours manually pipetting 96 crystallization conditions to preparing the same amount of samples in only two minutes, dramatically speeding up the discovery process.

A new bulk reagent dispenser in the Illumina Lab in Scholander Hall can rapidly fill well plates with two different liquids. By increasing efficiency, this can speed up the discovery process.

While this equipment lives at UC San Diego, the automation hub at Scripps will benefit the broader research community, with access available for faculty and students from neighboring institutions such as San Diego State University.

With these significant contributions to Scripps, CMBB envisions the creation of a new facility that would become the Biomedical Automation Facility. This facility could become a state-of-the-art hub for high-throughput screening equipment and genomics-enabled discovery.

Illuminas support was a part of the Campaign for UC San Diego, a university-wide comprehensive fundraising effort that concluded June 30, 2022 and raised a total of $3.05 billion to continue the universitys nontraditional path toward revolutionary ideas, unexpected answers, lifesaving discoveries and planet-changing impact.

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Illumina Supports Enhanced Genomics-Enabled Discovery and Training Programs at UC San Diego - University of California San Diego

Cell Biology

Renewal Bio Acquires Breakthrough Stem Cell Technology With Applications in Infertility and Longevity – Benzinga

Renewal Bio, a newly formed biotechnology company focused on infertility and longevity, today announced it has acquired an exclusive license from Yeda Research and Development Co Ltd, the commercial arm of the Weizmann Institute of Science, to a newly developed synthetic embryo technology. The technology was spearheaded by Prof. Jacob Hanna, Ph.D., M.D., as recently published in Cell, and builds on his research published in Nature last year. Renewal Bio plans to develop a bio platform that combines biology, hardware, and software to drive advancements and develop therapies for infertility, genetic diseases, lab-grown organs, and blood system rejuvenation.

The Problem: Humanity is Getting Older and Sicker

Since the turn of the century, developed nations have seen a clear trend: declining birth rates and fast aging populations. With significant socioeconomic implications, this trend threatens to upend health systems, retirement programs, and workforces across the globe. At the beginning of life, this is shown by a 5-10% increase in infertility treatments by U.S. couples each year. Towards the end of life, these issues are manifesting in fast-aging populations that balloon healthcare costs. In the U.S., the aging population is driving national health expenditures to increase at a rate of 5.5% per year, and are expected to reach more than $6 trillion annually by 2027.

The Solution: A Bio Platform to Renew Humanity

To solve these complex and compounding issues, Renewal Bio aims to make humanity younger and healthier by leveraging the power of the new stem cell technology. The technology can be applied to a wide variety of human ailments including infertility, genetic diseases, and longevity.

Renewal Bio's founding team includes:

Anyone interested in joining the company's mission of making humanity younger and healthier can learn more at renewal.bio.

About Renewal Bio

Founded in 2022, Renewal Bio mission is to renew humanity - making us younger and healthier. The company was founded by Omri Amirav Drory and Jacob Hanna to develop therapies ranging from infertility treatments to lab-grown organs using novel stem cell technology developed at the Weizmann Institute of Science. Learn more at renewal.bio.

About Yeda

Yeda Research and Development Company Ltd. is the commercial arm of the Weizmann Institute of Science. Yeda currently manages approximately 500 unique patent families and has generated the highest income per researcher compared to any other academic technology transfer operation worldwide. Through the years, Yeda has contributed to the commercialization of a number of groundbreaking therapies, such as Copaxone, Rebif, Tookad, Erbitux, Vectibix, Protrazza, Humira, and the CAR-T cancer therapy Yescarta. For more information, visit http://www.yedarnd.com/.

About the Weizmann Institute of Science

The Weizmann Institute of Science in Israel is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, Weizmann Institute's scientists are advancing research on the human brain, artificial intelligence, computer science and encryption, astrophysics and particle physics, and are tackling diseases such as cancer, while also addressing climate change through environmental, ocean, and plant sciences.

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Renewal Bio Acquires Breakthrough Stem Cell Technology With Applications in Infertility and Longevity - Benzinga

Cell Biology

Will baldness soon be a thing of the past? – San Bernardino County Sun

Despair not, ye men and women with ever-thinning pates: The follicles on your bald, shiny scalps arent dead. Theyre just, sort of, sleeping.

Researchers at UC Irvine liken those follicles to a sea of 3D printers, just waiting for the command to power up. And theyve figured out how to issue that command, recently micro-injecting a protein that sounds a bit like Scooby Doo into mice.

Our results identify SCUBE3 as a hair-growth activator, says their paper, published recently in the journal Developmental Cell. When microinjected for 4 days recombinant human SCUBE3 induced significant hair growth in mouse back skin.

Not only did SCUBE3 wake up dormant follicles to grow mouse fur, it also worked to grow human hair that was grafted onto the mice. Given time, that human hair could grow (and grow, and grow) longer than the mouses own fur would grow; longer than the mouses body, longer than the mouses tail.

The results were very promising, said Yingzi Liu, one of the researchers.

If youre envisioning a mouse with a Farrah Fawcett do, youre not alone.More than 50 percent of women experience balding, according to the American Hair Loss Association, and by age 50 about 85 percent of men are balding as well.

There are but two medications that treat or stave off hair loss: finasteride (Propecia, Proscar) and minoxidil (Rogaine, Ioniten). It can take at least 6 months for either treatment to start showing results. Theres a long road ahead before SCUBE3 can be tested on people, but the researchers have applied for a patent and hope to get to clinical trials in the next five or so years.

Scientists really care not only that things work, but how they work, said Maksim Plikus, professor of developmental and cell biology and a study author. Right now, were focusing on a deep dive into the mechanisms. But we are excited to the level that we filed for a patent. And were thinking that it has potential for people.

The issue here is dysfunctional signaling, he said. Stem cells for hibernating follicles arent disappearing; theyre just extremely dormant because theyre not getting the message that they should perform.

Questions to be explored next include efficacy and safety. SCUBE3 is a naturally occurring molecule, Plikus said, but how much can be delivered without seeing side effects? How much is too much?

Plikus lab studies how complex tissues and organs regenerate under normal conditions and in response to injury or disease. It aims to understand the nature of stem cell regulatory networks and regenerative behavior in response to organ injury.

Our ongoing work shows that the regenerative abilities of adult mammalian skin are far greater than previously thought, the Plikus labs web site says. In the center of large skin wounds cells can acquire an embryonic-like state and develop new, fully functioning hair follicles. Collectively, regenerative events can be so efficient that several months after wounding, scar tissue can hardly be distinguished from the normal skin.

Further research will be conducted in the Plikus lab and at Amplifica Holdings Group Inc., a biotechnology company co-founded by Plikus.The study team included health professionals and academics from UCI, San Diego, China, Japan, Korea and Taiwan.

The work was supported by grants from the LEO Foundation, Chan Zuckerberg Initiative, W.M. Keck Foundation, National Science Foundation, National Institutes of Health, Simons Foundation, National Natural Science Foundation of China and Taiwans Ministry of Science and Technology.

And, in case youre wondering: Plikus and Liu have thick, healthy heads of hair!

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Will baldness soon be a thing of the past? - San Bernardino County Sun

Cell Biology

Stopping Moles from Turning into the Deadliest Type of Skin Cancer – Boston University

New research from BUs School of Medicine shows that activating particular set of genes helps prevent moles from mutating into melanoma

In a small patch of skin no bigger than an inch, there are millions of cells all performing various duties, like protecting us from bacteria and sensing temperature. A portion of them are melanocytes, a type of cell dedicated to producing melanin, the substance that gives our skin, eyes, and hair color. If triggered by UV light from the sun, melanocytes can form moles, or beauty marks.

Though harmless moles are extremely common, some keep growing and growing, and mutating, until they turn into melanoma, the most deadly type of skin cancer. While melanoma accounts for only about 1 percent of all skin cancers, it causes the majority of skin cancerrelated deaths, most commonly in people under the age of 30, especially women. Approximately 30 percent of melanomas begin in existing moles on the skin.

But why do some moles keep growing, while others dont? And can the same molecular function that stops regular moles from proliferating be applied to cancerous cells? A Boston Universityled team of researchers has some answersand their findings could lead to new drug targets for the successful treatment of cancer.

In a paper published in Nature Communications, they discovered that a signaling pathway that regulates growth in all cellscalled the Hippo tumor suppressor pathwayplays a significant role in preventing the transformation of moles into melanoma. The pathway regulates growth by modulating two proteins in the cell. When active, these proteins change gene expression within cells to growth state. When inactivated, which happens when an organ reaches its full size, for example, the gene expression will change to stop growth in cells.

The Hippo pathway can monitor how squished the cells are, which is basically how it knows that something is done growing, says Neil J. Ganem, a corresponding author on the paper and a BU School of Medicine associate professor of pharmacology and medicine who studies differences between cancer cells and normal cells.

We thought thats what could be happening in these moles, and that the Hippo pathway stops the continuing growth of a mole, Ganem adds. They looked at mice and human cells to see what happened when the Hippo pathway was turned on or off.

When activated, we show the Hippo pathway restrains the growth of melanocytes and helps prevent their transformation into melanoma, says Marc Vittoria (MED23), a fourth-year medical student at BU and lead author of the study. Similarly, we found that when the Hippo tumor suppressor pathway is suppressed in melanocytes, those cells rapidly go on to form melanoma in multiple experimental models.

The study was supported by a five-year grant from the Melanoma Research Alliance (MRA), called the Jackie King MRA Young Investigator Award, named after a 21-year-old who lost their life to melanoma. The MRA aims to bring young biologists with expertise in cancer cell biology into melanoma research.

Melanoma is one of these cancers that can affect young people, making it particularly devastating, Ganem says. If you find it early, its easy to treat, but when you catch it late, and [it becomes] invasive, that is most difficult to treat.

Doctors will often monitor moles that could be suspicious and opt to remove any that change over time. And discovering the mechanisms our cells employ to protect against tumor formation is key to identifying new drug targets for the successful treatment of cancer.

We hope our study highlights that targeted reactivation of the Hippo pathway is an attractive therapeutic possibility for the future treatment of melanoma, Ganem says. Though the research team focused on the role of the Hippo pathway in preventing moles from transforming into melanoma, they believe it may be acting similarly in other subtypes of cancer.

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Stopping Moles from Turning into the Deadliest Type of Skin Cancer - Boston University

Cell Biology

Research Fellow, Mechanobiology Institute job with NATIONAL UNIVERSITY OF SINGAPORE | 303772 – Times Higher Education

Job Description

We are looking for a Postdoctoral Fellow with research experiences in Cell Biology or related Biomedical Sciences field. Relevant research areas include cell-cell junctions, cell signalling, cytoskeletal dynamics or related areas in mechanobiology. The successful candidate will lead a research project on the application of optogenetics to study adhesion proteins and cytoskeletons using advanced microscopy and molecular cell biology techniques.

Our laboratory is based at the Mechanobiology Institute (MBI), National University of Singapore (NUS). We are well equipped with state-of-the-art equipment and integrated core facilities support (microscopy, micro/nano-fabrication, protein expression and cloning, IT) as well as a vibrant and highly collaborative environment based on an Open Lab concept.

Compensation is internationally competitive and commensurate with experiences.

For more information, please visit our lab web site athttps://www.nanoscalemechanobiology.org

Qualifications

Candidates must have a Ph.D. degree in biology or related biomedical fields and outstanding publication record in relevant topics. Proficiency in mammalian cell biology, molecular biology, biochemistry, and live-cell fluorescence microscopy are desirable.

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presence is required.

Taking into consideration the health and well-being of our staff and students and to better protect everyone in the campus, applicants are strongly encouraged to have themselves fully COVID-19 vaccinated to secure successful employment with NUS.

More Information

Location: Kent Ridge CampusOrganization: Mechanobiology InstituteDepartment : ResearchEmployee Referral Eligible: NoJob requisition ID : 16760

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Research Fellow, Mechanobiology Institute job with NATIONAL UNIVERSITY OF SINGAPORE | 303772 - Times Higher Education