Letters to the editor: School start times and constraints on housing growth – The Almanac Online

School start times are only one factor in sleep deprivation

Pushing back school start times seems to be a solution to a symptom sleep deprivation rather than a solution to a problem, not going to sleep early enough the night before.

Researchers have found the hours of sleep we get before midnight make up the most powerful phase of sleep. During this first phase of sleep the body is replenished and rejuvenated, information we take in during the day gets reorganized, and adrenaline levels and stress are reduced. It is the qualities of our sleep during this early phase that is most important and not necessarily the quantity of sleep.

Why is this an issue now? The physiology of kids hasn't changed, has it? Sure, there are the occasional night owls, but a whole generation of night owls? No, that doesn't seem right. The root cause given in the Almanac article (the Aug. 12 issue story on school start times) is a phenomenon called circadian phase delay. The Mayo clinic defines circadian phase delay as a sleep disorder. Are we concluding that a whole generation has a sleep disorder? No, that doesn't seem right either. By definition, disorders are not common.

If a whole generation is finding it hard to fall asleep at a decent hour, there must be a ubiquitous cause. Are parents too permissive and not enforcing "bedtime?" Are kids on screens well into the night? Are today's kids not tired because they are generally less active than previous generations? Are kids being given too much homework to do at night? Any or all these causes could lead to sleep deprivation.

Increasing the length of kids' sleep by a few minutes in the morning may provide incremental benefits, but they are no substitute for all the benefits that would come from increasing the quality of their sleep by making lifestyle changes allowing kids to go to bed earlier.

Geoff Brosseau

Encina Avenue, Menlo Park

How much housing is too much?

Getting away from Bob Dickinson principal arguments about the Menlo Balance initiative (in his Aug. 12 guest opinion of The Almanac), which seem to be compelling on their face, I have questions: when is appropriate to seriously limit growth? When we need to drastically ration water? When we cannot move about our neighborhoods because of all the added traffic and congestion? When police and fire responders cannot arrive in a timely fashion? When the very reasons why we moved here cease to exist?

I was born in Glendale 81 years ago. To get to the beaches in Southern California then, you drove on roads that wound through orange grooves as there were no freeways. We have lost the reasons why my parents and others moved here, why I remain here, to massive development, to sprawling planned communities which have eliminated farmlands, to commute times which now are measured in hours; more of the same is not the answer.

We should be encouraging businesses to migrate to more remote rural areas, we should remove the tax incentives for homeownership and subsidize other forms of housing, and we must create criteria to be met before we allow more well-intentioned but thoughtless plans for new housing. For every new resident, two must be asked nicely to leave.

Jeff Colflesh

North Fair Oaks

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Christine Kasper named the new dean of the University of Pittsburgh School of Nursing – University of Pittsburgh

Christine E. Kasper, who served the past four years as dean of the University of New Mexicos College of Nursing, has been named the new dean of the University of Pittsburgh School of Nursing after a highly competitive national search.

On Jan. 1, 2023, Kasper will replace Jacqueline Dunbar-Jacob, dean and Distinguished Service Professor of Nursing, whose leadership and dedication over the last 21 years have positioned Pitt Nursing as one of the top nursing schools nationwide.

Dr. Kasper has been chosen from a pool of exceptionally qualified leaders identified through a national search, said Anantha Shekhar, senior vice chancellor for the health sciences and the John and Gertrude Petersen Dean of the School of Medicine. I believe Dr. Kasper is superbly qualified to lead Pitts School of Nursing on a continued path of success, and I look forward to working with her closely.

In her role at UNM, Kasper leads a nursing college with more than 1,100 students. In the previous three years, enrollment in UNMs College of Nursing increased by 35%.

Before joining UNM, Dean Kasper served as a senior nurse executive in the U.S. Department of Veterans Affairs, Office of Nursing Services. In that post, she advised the chief nursing officer on academics, research and policy and was a professor in the Daniel K. Inouye Graduate School of Nursing at Uniformed Services University of the Health Sciences in Bethesda, Maryland.

[Pitt School of Nursing tops 2022 U.S. News & World Report online masters ranking with a perfect score]

I am mindful of the unique and essential role that a highly ranked and world-class major research university such as the University of Pittsburgh plays in its mission as a model public university serving the state, the nation and international communities, said Kasper said. The University of Pittsburgh School of Nursing has long served as one of the preeminent elite nursing schools in the country. Over its long and distinguished history, it has been a leader and innovator in the profession's education, scholarship and research.

Kasper is the current editor of the Annual Review of Nursing Research and was the founding editor of Biological Research for Nursing. She was elected as a fellow of the American Academy of Nurses in 1994, elected as a fellow of the American College of Sports Medicine in 1995 and elected to the International Nurse Researcher Hall of Fame, Sigma Theta Tau International in 2015.

She has more than 200 national and international peer-reviewed and invited publications, books and presentations to her credit.

Kasper received her undergraduate degree in nursing from the University of Evansville, a masters in nursing from Rush University and a PhD from the University of Michigan, where she studied nursing and exercise physiology. Following a postdoctoral fellowship at Rush University in physiology and biophysics, she served as a professor at University of Wisconsin-Madison and the University of California, Los Angeles . She also held the M. Adelaide Nutting Research Chair at Johns Hopkins University.

Jared Stonesifer

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Christine Kasper named the new dean of the University of Pittsburgh School of Nursing - University of Pittsburgh

Which Foods Can Alter The Brain And Mood, According To Neuroscience – Nation World News

Food components and their breakdown products can modify the genetic instructions that control the physiology of the human body

loss Foods those that are consumed or the lack of consumption of certain cans affect the mood of people every day. One case that is remembered in the history of nutrition is the long sea voyages of the fifteenth and sixteenth centuries: sailors experienced visions of sublime food and lush fields. Finding out that they were nothing more than hallucinations after months at sea was unbearable for them. It was later discovered that the sailors suffered from scurvy, a disease that develops from a severe lack of vitamin C in the diet. Lemon juice was given as a treatment and it was effective.

Scurvy is now rare in many countries, and vitamin C, a micronutrient, can be obtained by eating fruits and vegetables. From neuroscience, efforts are being made to better understand the effect of food on brain health. according to the scientist Monica DusoAssociate Professor of Molecular, Cellular and Developmental Biology at the University of Michigan in the United States, loss food ingredient and their decomposition products can modify genetic instructions who control the physiology of the human body.

It is already known that a delicate balance of nutrients is key to brain health: deficiencies or excesses of vitamins, sugars, fats and amino acids can affect the brain and behavior in beneficial or harmful ways. it means that Consuming a complete diet, including a balanced supply of all essential vitamins and minerals, is important for brain health.

Vitamin C is important for the production and release of neurotransmitters, chemical messengers used by the brain.

In Vitamin C is important for the production and release of neurotransmitters, chemical messengers used by the brain. Without it, brain cells dont communicate with each other effectively, which can lead to hallucinations, Dr. According to Dus.

Like vitamin C, deficiencies in other vitamins and minerals can also lead to nutritional diseases that negatively affect the brain in humans. For example, Low levels of vitamin B3/niacin in the diet commonly found in meat and fish cause pellagra, a disease in which people develop dementia.

Niacin is essential for the body to convert food into energy and building blocks, protects the genetic blueprint from environmental damage, and controls the amount of certain gene products produced. In the absence of these vital processes, brain cells, that is, neurons, degenerate and die prematurely. This can lead to dementia.

Niacin is a type of B vitamin. Increasing levels of this vitamin benefits patients with neurodegenerative problems / Archive

In animal models, decreasing or blocking niacin production in the brain promotes neuronal damage and cell death. On the other hand, increasing levels of niacin have been shown to reduce the effects of neurodegenerative diseases such as Alzheimers, Huntingtons and Parkinsons. Although the results are not yet conclusive, observational studies in humans indicate that adequate levels of niacin may protect against these diseases, Dus wrote. Conversation, its funnyNiacin deficiency can cause pellagra-like effects due to excessive alcohol consumption.

Another example of how nutritional deficiencies affect brain function Its all about the element iodine, which, like niacin, must be obtained through the diet. It is naturally present in shellfish and algae, and can also be obtained through iodized salt. Iodine is an essential component of thyroid hormones, signaling molecules that are important for many aspects of human biology, including growth, metabolism, appetite and sleep. Low iodine levels inhibit the production of thyroid hormones in sufficient amounts, impairing these essential physiological processes.

Iodine is particularly important for the development of the human brain. In fact, before table salt was supplemented with this mineral in the 1920s, Iodine deficiency was one of the leading causes of cognitive dysfunction worldwide. The introduction of iodized salt is believed to have contributed to the gradual increase in IQ scores over the past century.

A study in Italy led by Giovanni Ferrello showed thatPeople with drug-resistant epilepsy a condition in which brain cells fire uncontrollably can reduce the number of seizures by adopting a very low-carbohydrate diet, in which 80% to 90% of calories are derived from fat. The work was published in the journal Nutrients,

Carbohydrates are the bodys preferred source of energy. When they are not available whether from fasting or a ketogenic diet your cells get fuel by breaking down fats into compounds called ketones. Using ketones as an energy source causes profound changes in metabolism and physiology, including the levels of hormones circulating in the body, the amount of neurotransmitters produced by the brain, and the types of bacteria that live in the gut.

Researchers believe that these diet-dependent changes, particularly the increased production of brain chemicals that can calm neurons and lower levels of inflammatory molecules, may lead to a ketogenic diet to reduce the number of seizures. capacity can play a role. These changes may also explain the benefits of the ketogenic state either through diet or fasting on cognitive function and mood.

Also, it has been known from various studies that excessive levels of certain nutrients can also have harmful effects on the brain. In humans and animal models, high intakes of refined sugars and saturated fats a combination commonly found in ultra-processed foods deactivate the brain for hormonal signals known to regulate feelings of satiety and satisfaction. Promotes food intake.

A diet containing many highly-processed foods also weakens the taste system: it causes animals and humans to perceive foods as less sweet. These sensory changes can affect food choice, as well as the rewards that come with it. Dr. Ten and a team of colleagues demonstrated this change in a study published in the journal Trends in Endocrinology and Metabolism,

Research shows, for example, that Peoples responses to ice cream in brain regions important for taste and reward blurred when they ate it every day for two weeks. Some scientists believe that this reduction in food reward signals may increase cravings for more fatty and sugary foods, in the same way that smokers crave cigarettes.

Diets rich in fat and processed foods are also associated with reduced cognitive function and memory in humans and animal models, as well as a higher incidence of neurodegenerative diseases. However, scientists do not yet know whether these effects are due to these foods or the weight gain and insulin resistance that develop from long-term consumption of these diets.

The effect of food can also vary over time. Some can profoundly affect brain function and behavior as in hours or days while others take weeks, months or even years to take effect. For example, Eating a piece of cake changes the ketogenic, fat-burning metabolism of a person with drug-resistant epilepsy to a carbohydrate-burning metabolism, increasing the risk of seizures.

other thing, It takes weeks of sugar consumption for the brain to alter taste and reward pathways, and months of vitamin C deficiency to develop scurvy. eventually, When it comes to diseases like Alzheimers and Parkinsons, the risk is influenced by years of dietary exposure. In combination with other genetic or lifestyle factors such as smoking.

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UTHSC-Led Team Receives $3.16 Million from National Cancer Institute for Cancer Immunotherapy Drug Development – UTHSC News – UTHSC News

A UTHSC-led team has received $3.16 million from the National Cancer Institute to develop a drug that boosts the immune system response in cancer patients to destroy tumor cells. Gabor Tigyi, MD, PhD, Harriet Van Vleet Endowment Professor in the Department of Physiology, is the lead investigator. Sue Chin Lee, PhD, associate professor in the same department, is a principal investigator.

Cancer immunotherapy is one of the hottest areas of personalized medicine that unfortunately fails in many patients because of the ways cancerous cells are able to sidestep and inhibit the bodys anti-tumor response. Dr. Lee and Dr. Tigyi have identified a key inhibitor of cytotoxic T cell activation, the killer cells that eliminate cancerous cells. Working with Corinne Augelli-Szafran, PhD, vice president of Scientific Platforms at Southern Research in Birmingham Alabama, they have designed drug candidates that Raul Torres, PhD, professor of Immunology and Microbiology at the University of Colorado, has shown overcome the blockade of tumor-killing immune cells.

We are very astonished that our grant application received a perfect 1 percentile score from the National Cancer Institute review panel. That reflects the excitement of our peers recognizing the significance of our proposal, said Dr. Tigyi, who is also the associate vice chancellor for Research, Global Cooperation, and Industry Relations. The key to our success was embedded in the complementary expertise and distinguished research track record of our team members.

Dr. Lee provided crucial preliminary data for the grant application, identifying the lead candidate compound now being used to develop the new therapeutic. Her preliminary data gathering was made possible by a 2018 CORNET award, a competitive intramural grant program funded by the UTHSC Office of Research that promotes new lines of interdisciplinary team study. In this case, the $50,000 CORNET award bolstered an academic-industry partnership between UTHSC and Southern Research, and now, four years later, has yielded a multiple principal investigator award that is worth millions.

The development of a relationship between UTHSC and Southern Research, exemplified by our joint CORNET awards, has been an exceptionally important step in developing the drug discovery and development pipeline at UTHSC, said Steve Goodman, PhD, UTHSC vice chancellor for Research. I want to congratulate Dr. Lee, Dr. Tigyi, Dr. Augelli-Szafran, and Dr. Torres on their outstanding work and the resultant multi-PI NCI grant award.

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Epicore Biosystems and Denka Partner to Tackle Asia’s Dehydration Crisis Through Sweat-Sensing Wearable Technology – StreetInsider.com

Partnership launches Epicore Biosystems into the Asia market, expanding its global footprint

CAMBRIDGE, Mass., Aug. 30, 2022 /PRNewswire/ --Epicore Biosystems, a digital health company developing advanced sweat-sensing wearables that provide real-time personalized health insights for hydration, stress and wellness, today announced a partnership with Denka Corporation, a Japan-based multinational technology and materials company. Under the agreement, Epicore Biosystems and Denka will collaborate on strategic initiatives to pilot and distribute Epicore's portfolio of advanced wearable hydration solutions in Japan and expand into Asia markets.

The partnership comes at a critical time as rising heatwaves continue to spread across Asia with no signs of slowing down as experts warn the world could hit a climate high by 2024. As a result, many Asia residents are experiencing excessive heat exposure and dehydration, which can have harmful effects on cognitive and physical performance, as well as physiological function. In June 2022 alone, more than 15,000 people needed hospital care across Japan. These issues are more notably visible among individuals in sports, industrial work, and military training, among others.

"As temperatures continue to rise in countries around the globe, dehydration has become a leading cause of concern," said Roozbeh Ghaffari, CEO and co-founder of Epicore Biosystems. "There is now an enormous demand to address these challenges and identify personalized solutions for tackling hydration problems before they impact long-term health. Our collaboration with Denka enables us to unlock new opportunities and address hydration challenges head-on within the Asia market."

Epicore Biosystems develops advanced wearable solutions that measure sweat biometrics and provide customized recovery insights about hydration, including sweat rate, total sweat loss, sodium chloride concentration and total sodium chloride loss all captured with an unobtrusive wearable sweat sensor, analyzed through a proprietary cloud engine, and delivered directly to the wearer through a smartphone application and cloud portal. Denka and Epicore Biosystems will first survey the needs of those within the sports and wellness industries in Asia, with plans to expand into industrial and medical applications, such as identifying dehydration and fatigue in elderly patients, soon after.

"Recent summers in Japan have been extremely hot, and countermeasures against heat stroke and dehydration are an urgent issue," said Nobuyuki Yoshino, managing executive officer at Denka. "This partnership will enable us to leverage Epicore Biosystems' wearable hydration solutions to address the needs of athletes, as well as industrial workers, who are impacted most by the rising temperatures. Through collaboration with Epicore Biosystems, we hope to contribute to solving various health issues."

Epicore Biosystems' suite of sweat-sensing wearables includes the Gx Sweat Patch created in partnership with PepsiCo and Gatorade, the Discovery Patch Sweat Collection System, and the Connected Hydration wearable hydration sensor and mobile application tailored for industrial athletes and sports.

The technology has been developed and tested with leading sports physiology labs and research hospitals, including the Northwestern University Feinberg School of Medicine, University of Connecticut Korey Stringer Institute, University of Massachusetts Amherst Center for Human Health and Performance, and the Gatorade Sports Science Institute.

Denka and Epicore Biosystems' partnership officially went into effect this month with the goal to bring personalized hydration products to the Asia markets in the next 18 months.

To learn more about the company and its solutions, visit https://www.epicorebiosystems.com/.

About Denka

Denka is a chemical manufacturer headquartered in Tokyo, Japan. The company specializes in developing business activities on a global scale across a wide range of fields from inorganic and organic chemicals to electronic materials and pharmaceuticals. Founded in 1915, Denka has steadily continued to develop and manufacture products that contribute to the development of society by fully utilizing its unique concepts and technological capabilities. To learn more, visit https://www.denka.co.jp/eng/

About Epicore Biosystems

Founded in 2017, Epicore Biosystems is a digital health company developing advanced sweat-sensing wearables that provide real-time personalized health insights for hydration, stress and wellness. Their clinically validated products are deployed globally and licensed by leading Fortune 500 companies, the Department of Defense and the National Institute of Health in the sports and fitness, occupational safety and clinical trials industries.

Epicore Biosystems was co-founded by leading scientists from Northwestern University's Querrey Simpson Institute for Bioelectronics. The founding team has several decades of experience launching science-backed medical wearables and consumer health products. To learn more, visit https://www.epicorebiosystems.com/.

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8 Jobs To Pursue With a Biochemistry Degree | Indeed.com

By Indeed Editorial Team

Published April 13, 2021

If science is your favorite school subject, consider a biochemistry role. This lab-based science studies why certain substances cause reactions in the cells of various living beings. There are many specialties you can pursue within this degree that can ready you for careers like biochemists, chemical engineers or professors. In this article, we review what biochemistry is, tips for becoming a biochemist and the different roles you can pursue with a biochemistry degree.

Biochemistry is the combination of chemistry, physics and biology. Biochemistry professionals study how these different elements of science affect various living beings and organisms. Many students looking to explore the chemical processes that take place within a living system typically major in biochemistry. Most of the careers you can earn in this degree vary according to your preferred responsibilities and work environment. This degree allows you to specialize in a wide variety of fields, including chemistry, biology and research.

To become a biochemist or to work in the biochemistry field, you must have impressive scientific skills, knowledge and capabilities. You can earn these qualifications by taking the proper courses and gaining relevant experience in your field. Follow these tips to become a successful biochemist:

Earn a high school diploma: You should first graduate high school with your diploma or a GED. Try to take courses like physics, chemistry, mathematics and biology to familiarize yourself with the basic scientific concepts you may later go in-depth on in your bachelor's program.

Get a bachelor's degree: Most employers require biochemistry candidates to earn at least a bachelor's degree in biochemistry, biology, chemistry or another related field.

Select elective courses: Many programs offer elective courses depending on the area of the biochemistry field that you'd like to pursue. You can take courses that help you advance your education further into the medical, biotechnology or veterinary master's degree programs.

Participate in lab work: A majority of biochemistry careers take place in a laboratory. You may complete lab work during your courses to familiarize yourself with the tools and overall lab atmosphere. You can also pursue an internship in a lab to gain hands-on lab training and experience.

There are a wide variety of fields you can pursue, such as forensic science, chemistry and biology, after you earn a biochemistry degree. Common jobs people with biochemistry degrees typically pursue include:

National average salary: $51,544 per year

Primary duties: A forensic science technician assists forensic scientists in criminal investigations to perform tests and report their results. Common job responsibilities include collaborating with law enforcement at crime sciences to collect DNA, running DNA profiling and chemical analysis tests, testifying as an expert witness in court and handling hazardous and contaminated pieces of physical evidence safely and responsibly.

Related: Learn About Being a Forensic Science Technician

National average salary: $63,734 per year

Primary duties: Forensic scientists process various pieces of evidence to help law enforcement prosecute suspects in criminal cases. Other responsibilities include interpreting blood spatter patterns at crime scenes, tracing drugs and other illegal substances in tissues and bodily fluids, managing and preserving crime scenes until the necessary personnel arrives and conducting post-mortem investigations on crime scene victims.

National average salary: $63,908 per year

Primary duties: A chemical engineer uses their advanced knowledge of mathematics and different areas of science to enhance the processes used in chemical experiments. They also work to find solutions to problems that scientists in the chemical industry may regularly undergo. Other key job duties include building, proposing and implementing plans to reach chemical companies' goals, increasing the quality and efficiency levels of chemical processes and compiling and analyzing data gained from on-site visits.

Related: Learn About Being a Chemical Engineer

National average salary: $65,066 per year

Primary duties: A biochemistry professor works for a university, college or other academic institution teaching students about different elements of biochemistry. Their main duties include providing lectures, administering tests, quizzes and assignments, conducting office hours to address students' questions about the lectures, overseeing lab experiments students conduct and developing syllabi that reflects the program's required curriculum.

National average salary: $79,272 per year

Primary duties: A biochemist conducts studies and experiments on the composition and functions of different life forms to determine how various chemical processes affect them. Other key job responsibilities include designing and executing scientific experiments, analyzing and recording large data sets and results, making recommendations on chemical processes based on their findings and refining chemical compounds for medical professionals or the public to use.

National average salary: $80,831 per year

Primary duties: A biologist studies plant life and other organisms to make discoveries about their behaviors, compositions and habitats. They also conduct research on these living beings to determine how other beings or organisms affect their environments. Other job duties include identifying, studying and classifying animals, plants and ecosystems, taking samples and measurements of organisms, learning more about organisms' diets and behaviors and maintaining detailed and accurate records related to their scientific research.

National average salary: $94,755 per year

Primary duties: A medical scientist conducts research on human illnesses and diseases to uncover ways to improve the health of humans. Other job responsibilities include conducting studies to investigate human diseases and potential treatment methods, analyzing medical data and samples to determine causes and dangers of certain chronic diseases or pathogens, building and testing various medical devices and writing research grant proposals for funding applications from private funding and government sources.

National average salary: $111,143 per year

Primary duties: A research scientist conducts experiments on different scientific concepts to prove or disprove certain scientific theories or insights. Other job responsibilities include proposing innovative scientific research ideas, spearheading data collection processes and efforts and publishing important findings in scholarly and academic journals.

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New Program Honors Effective Teachers and Rekindles Joy in Education | College of Human Medicine | Michigan State University – Michigan State…

August 30, 2022

In the midst of the pandemic, with teaching and many other parts of life disrupted, Randi Stanulis decided it was time to rekindle the joy that College of Human Medicine faculty members find in helping students grow and succeed.

I know that coming out of the pandemic, we found that many of us were experiencing burnout and people feeling we were stretched too thin, said Stanulis, PhD, assistant dean for faculty development and director of the colleges Office of Medical Education Research and Development (OMERAD). It made me think we needed to do something about it.

Thus, a year ago was born Finding Joy in Teaching, an honorific program based on the belief that the best teachers love what they do. Research shows that the most effective teachers not only like what they do, but are flexible and focused on student growth, Stanulis said.

There are a lot of people who say, I teach biochemistry, she said. I say, No, you teach students about biochemistry. That shift is significant.

A year ago, College of Human Medicine department chairs and directors nominated faculty members known for their effective teaching skills and enthusiasm. Stanulis then led the recording of a series of 10 short audio presentations offering the honorees perspectives and suggestions on the joy of teaching. The episodes were posted online and celebrated at the inaugural Joy in Teaching reception, funded in part by the Dr. Ruth Allen Endowment in OMERAD.

The idea for this movement is to elevate a culture where teaching effectiveness is valued and where peers can see what others are doing and be inspired by that, Stanulis said, adding that it really raised awareness to another level that teaching is joyful, is recognized, and is valued at the College of Human Medicine.

While research is an important part of the colleges mission, skillful teaching is equally essential, she said.

In October, department chairs and directors will nominate a second cohort of faculty members to be recognized for their teaching excellence in Finding Joy in Teaching. Those chosen will add their perspectives to the audio series collection and will be honored in the spring. For most, it is clear through listening to their audio episodes, teaching is its own reward.

For 18 years, Stanulis was a professor in MSUs Department of Teacher Education in the College of Education before becoming director of OMERAD.

I enjoy the energy that comes from students when they are actively involved, she said. I enjoy their curiosity. I enjoy seeing them light up as they learn.

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Expert In Biochemistry Dr. Yesu Addepalli Works On A Micro Level To Bring Macro Changes To The Development Of Novel Therapeutics – Tech Times

(Photo : Dr. Yesu Addepalli)

In addition to studying the complex chemical and physical properties of living things, dissecting their cellular structures, and understanding how they interact with different compounds, biochemists play a key role in providing the foundational knowledge and science used to develop health treatments and medical drugs.

Dr. Yesu Addepalli is a renowned expert in the field of biochemistry, having played a critical role in the drug discovery and synthesis of biologically active small molecules. This work has the potential to be revolutionary for the biopharmaceutical industry, as our society battles a wide variety of viruses and diseases. The PHD holder has a unique and valuable perspective thanks to his multifaceted education in organic chemistry, medicinal chemistry, and chemical biology.

Dr. Addepalli was instrumental in the development of antiparasitic drugs for leishmaniasis and trypanosomiasis. When asked about his methods, he explains: "My efforts were geared towards the utilization of chemical derivatization and forward genetic approaches to study a class of compounds that selectively test derivatives for selective activity on Leishmania tubulin and trypanosomatids. [From there, I] assessed their stability, solubility, cell permeability, and in vivo PK properties. [I] performed proof-of-concept testing in the mouse model of leishmaniasis and used a modular synthetic strategy, and Cryo-EM techniques to discover the binding site of a class of pyrimidinone derivatives. [Finally I] optimized promising agents for oral administration and performed dose response testing in animal models."

This work, at the University of Texas Southwestern Medical Center's Ready laboratory, will allow the development of compounds with a high therapeutic index for the treatment of trypanosomatid infections, based on the identification of molecules that inhibit targeting parasite tubulin polymerization. The newly found understanding of the drug target and mechanism brings promise for the treatment of these arthropod-borne diseases.

Dr. Yesu Addepalli earned his Master of Science degree in organic chemistry from the Government College (Autonomous), Rajahmundry in India before going on to complete his doctoral degree in organic chemistry under the guidance of Research Advisor Prof. Yun He at Chongqing University in China. Most recently, he has been working in a postdoctoral position with esteemed-researcher Professor Joseph Ready at the University of Texas Southwestern Medical Center, which provides him with both the tools and community to evolve and deepen his studies.

"I find bioactive small molecules to be fascinating. The design, synthesis, purification, and characterization of viruses and [their] treatment drugs are a wonder to behold, study, and develop." Dr. Addepalli shares, "Some people find beauty in the world around [them], but I see beauty in the microscopic world of viruses and find great pleasure in being instrumental in halting the spread of viruses through synthesizing biopharmaceuticals."

Although the work is rewarding,Dr. Yesu Addepalli recognizes that it is also a great responsibility, as each challenge is fundamentally a battle between life and death. He is grateful for the diversity of knowledge and skills that his team holds, as it brings them closer to streamlined bioactive molecule development. He is also currently collaborating with biologists at UT Southwestern, and elsewhere, using high-throughput screening strategies to discover small molecules with promising biological activity in an effort to identify compounds and molecules that will push the boundaries of genetic studies. The characterization of biologically active small molecules is a breakthrough for the development of novel therapeutics for neurodegenerative and infectious diseases, as well as for cancer.

Dr. Addepalli's esteemed work has been featured in a variety of reputable publications, and he also has a US patent for his team's work specifically with novel antiparasitic compounds and methods. He is an active member of the American Society for Biochemistry and Molecular Biology, as well as the Society for Immunotherapy of Cancer. In his free time, he also enjoys reviewing for publications such as Tetrahedron and Heterocyclic Chemistry.

His work revolves around molecules and compounds that are far too small to see with the naked eye, but the impact of his work has a very large scope. As our society has recently been reminded of the threat that these microscopic elements can bring, the work of Dr. Addepalli is perhaps more important than ever before. Gaining a stronger understanding of how these microscopic molecules create disease will help us to understand how to reverse and treat the disease. As they say, knowledge is power.

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Carleton University and Turnstone Biologics Extend partnership for Research and Training in Biosciences – Carleton Newsroom

Carleton University today announced the extension of its partnership with Turnstone Biologics (Turnstone), a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumours. The partnership, renewed for a second term, further supports Carletons growing biosciences programs and the development of scientific talent, and augments the universitys expertise in novel oncology research.

This is an opportune time to extend our partnership with Turnstone as we prepare to launch our Life Sciences 2030 Plan, said Maria DeRosa, PhD, Dean of Science and Professor in the Department of Chemistry and the Institute of Biochemistry, Carleton University. Our vision of positioning Carleton as the premier Canadian post-secondary institution for training, talent development and research in the life sciences sector is significantly enhanced through our innovative and productive relationship with Turnstone.

Since 2019, Turnstone has conducted internal development work and sponsored research at Carleton University. The research being undertaken at Carleton includes generating new insights into how cancer therapies regulate immune cells and their effects on new candidate treatments, and how viruses and environmental toxins contribute to the development of chronic diseases. Additionally, representatives of Turnstone have mentored students and participated in life sciences events on campus.

Carleton University offers a wonderful and vibrant academic community. The partnership with Carleton allows us to interact with a variety of excellent researchers and promising students to create opportunities to collaborate, foster scientific ideas and invest in the brilliant minds of the future, said David Stojdl, PhD, Scientific Co-Founder, Senior Vice President and Senior Scientific Fellow, Turnstone Biologics.

The extension of the partnership enables Turnstone to continue engaging graduate students and to provide them with support to conduct research in the areas of immunology, microbiology, biochemistry, biotechnology and bioinformatics. The partnership promotes integration with students through Work-Integrated Learning (WIL), job shadowing and experiential education. Graduates will also have the opportunity to closely interact with Turnstones researchers to receive guidance and mentorship.

Talent development is a key objective of this exciting and mutually beneficial research partnership. Together through our partnership, Carleton University and Turnstone are preparing the next generation of life sciences researchers to continue advancing immunotherapies with the aim of improving the survival rate of people with cancer, said Rafik Goubran, PhD, Vice-President (Research and International) and Chancellors Professor, Carleton University.

About Carleton University

Carleton is a dynamic, research-intensive institution that engages in partnerships to addressthe worlds most pressing issues. The universitys corporate collaborations bring together world-class companies, researchers and a new generation of talent with 32,000 students to deliver innovations and results that are driving a more prosperous, sustainable future.

About Turnstone Biologics

Turnstone Biologics, a clinical stage biotechnology company, is developing new medicines to treat and cure solid tumours by pioneering differentiated approaches with two clinically-validated technologies, tumour infiltrating lymphocyte (TIL) therapy and viral immunotherapy. Turnstones innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumour indications by selecting and manufacturing the most potent tumour-reactive T-cells (Selected TILs) for tumour eradication, represents the Companys foundational therapeutic modality driving its cancer immunotherapy pipeline. The Companys lead Selected TIL therapy candidate, TIDAL-01, is expected to enter clinical trials in 2022. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

For more information, please visit http://www.turnstonebio.com, and follow Turnstone on LinkedIn.

Media ContactSteven Reid (he/him)Media Relations OfficerCarleton University613-265-6613Steven.Reid3@carleton.ca

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Carleton University and Turnstone Biologics Extend partnership for Research and Training in Biosciences - Carleton Newsroom

Research on the Road | The UCSB Current – The UCSB Current

Call it lucky number 10.

Six graduate students, three faculty members and one staff member from UC Santa Barbara have received Fulbright Awards from the U.S. Department of State and the Fulbright Foreign Scholarship Board to conduct research and/or teach abroad for the upcoming academic year.

The highly competitive fellowship is designed to increase mutual understanding between the people of the United States and the people of other countries.

Students are selected for Fulbright Fellowships on the basis of their academic and professional achievements, as well as their record of service and leadership potential in their respective fields.

Every year the Graduate Division, along with the Office of Undergraduate Education and faculty reviewers from across campus, support applicants to the Fulbright U.S. Student Program who seek to do research, teach or study for a year in places all over the globe, said Shawn Warner, Graduate Divisions director of professional development.We are so excited that over a third of our campus 15 applicants to the program for the upcoming year were selected as awardees. These 6 students will spend the upcoming academic year carrying out their projects in 5 different countries, all while supporting the Fulbright mission of cultural exchange and ambassadorship.

The winning fellows, their departments, projects and host countries are:

Clara Bailey, Chemistry and Biochemistry, Engineered Microbiomes for Soil Pollutant Remediation (Switzerland)

Sabra Harris, East Asian Language and Cultural Studies, Emergent Indigeneities within Public-Facing Ainu Performance (Japan)

Johanna Krukowski, Theater and Dance, Spectral Frequencies: Recovering the Lost History of Australian Horror Radio (Australia)

Jackson Stephenson, Religious Studies, The Afterlife of Indian Esoteric Buddhist Poetry (India)

Felicity Stone-Richards, Political Science, The Search for Acknowledgment: Anti-Racist and Pro-Immigration Praxis in Japan (Japan)

Kira Weiss, Music, A Contested Symbol with a Dynamic Voice: The Cello and Egyptian Cultural Policy (Egypt)

In addition, three faculty members and one UCSB staff member have received Fulbright U.S. Scholar Program awards:

Professor Paul Amar, Global Studies (Brazil) Associate Professor William Elison, Religious Studies (India)Professor Paul Leonardi, Technology Management (Austria) Regional Advisor Megan Pankratz, Education Abroad Program (Korea)

Fulbright Scholars engage in cutting-edge research and expand their professional networks, often continuing collaborations started abroad and laying the groundwork for future partnerships. Upon returning to their home countries, institutions, labs and classrooms, they share their stories and often become active supporters of international exchange, inviting foreign scholars to campus and encouraging colleagues and students to go abroad. Fulbright Scholar alumni include 61 Nobel Prize laureates, 89 Pulitzer Prize recipients, and 40 who have served as a head of state or government.

Over its 75-year history, the Fulbright Program has provided more than 400,000 participants chosen for their academic merit and leadership potential with the opportunity to exchange ideas and contribute to finding solutions to challenges facing our communities and our world. More than 800 U.S. scholars, artists and professionals from all backgrounds annually teach or conduct research overseas through the Fulbright U.S. Scholar Program. Additionally, over 1,900 diverse U.S. students, artists and early career professionals in more than 100 different fields of study receive Fulbright U.S. Student Program grants annually to study, teach English and conduct research overseas.

As the U.S. governments flagship international educational exchange program, the Fulbright Program is funded through an annual appropriation made by the U.S. Congress to the U.S. Department of States Bureau of Educational and Cultural Affairs. Participating governments and host institutions, corporations and foundations around the world also provide direct and indirect support.

In the United States, the Institute of International Education supports the implementation of the Fulbright U.S. Student and Scholar Programs on behalf of the U.S. Department of State, including conducting an annual competition for the scholarships.

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Research on the Road | The UCSB Current - The UCSB Current