Regularly Exercising With Weights Linked to Lower Risk of Death – Neuroscience News

Summary: Regular weight training exercise is associated with a reduced risk of death, a new study reports. Incorporating aerobic exercise with weight-based exercise adds to the protective effect.

Source: BMJ

Regularly exercising with weights is linked to a lower risk of death from any cause, with the exception of cancer, finds research carried out in older adults and published online in theBritish Journal of Sports Medicine.

And ensuring that a weekly exercise routine includes both weights and aerobic activities seems to have an additive effect, the findings suggest.

Current guidelines on physical activity for all adults recommend at least 150 weekly minutes of moderate intensity aerobic activity, or a minimum of 75 minutes of vigorous intensity aerobic activity, or an equal combination of the twousually referred to as MVPA (moderate to vigorous physical activity).

All adults are also recommended to incorporate activities that work all the major muscle groups. Yet while aerobic exercise is consistently associated with a lower risk of death, its not clear if working out with weights might have similar effects.

In a bid to plug this knowledge gap, the researchers set out to evaluate separately and jointly the potential impact of exercising with weights and aerobic activities on the risk of death among older adults.

They drew on participants from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. This began in 1993 and includes 154,897 men and women aged 5574 from 10 different cancer centres in the United States.

In 2006, 104,002 of the participants were additionally asked if they had exercised with weights over the past year, and if so, how often they had done soanything from less than once a month to several times a week.

And they were asked about the frequency and duration of both moderate and vigorous intensity physical activity over the past year.

Moderate intensity was described as activity where you worked up a light sweat or increased your breathing and heart rate to moderately high levels and vigorous activity as activity strenuous enough to work up a sweat or increase your breathing and heart rate to very high levels.

Four activity groups were generated based on total weekly minutes of MVPA: (1) inactive, 0 minutes; (2) insufficient aerobic MVPA, 1149 minutes; (3) sufficient, 150+ minutes of moderate, or an equivalent amount of vigorous, activity; and (4) highly active, 301 or more minutes of moderate, or an equivalent amount of vigorous, activity.

In all, the responses of 99,713 people were included in the final analysis, 28,477 of whom died over an average of 9 years of monitoring. Their average age at the start of the monitoring period was 71, and the average weight (BMI) was 27.8 kg/m2which is defined as overweight.

Nearly 1 in 4 (23%) respondents reported some weightlifting activity; 16% said they exercised with weights regularly between one to six times a week. Nearly a third (32%) were sufficiently aerobically active, either meeting (24%) or exceeding (8%) the guidelines on MVPA.

Exercising with weights and aerobic MVPA were both independently associated with a lower risk of death from any cause, as well as from cardiovascular disease, but not from cancer.

Overall, working out with weights in the absence of MVPA was associated with a 9-22% lower risk of death, depending on the amount: for example, using weights once or twice a week was associated with a 14% lower risk.

Similarly, among those who didnt exercise with weights, aerobic MVPA was associated with a 24-34% lower risk of death from any cause, compared with those who reported neither MVPA nor exercising with weights.

But the lowest risk of death was seen among those who said they did both types of physical activity.

For example, the risk of death was 41-47% lower among those who said they met most recommended weekly levels of MVPA and who exercised with weights once or twice a week than it was among those who were physically inactive.

Educational attainment, smoking, BMI, race and ethnicity didnt significantly change the associations observed, but sex did: the associations were stronger in women.

This is an observational study, and as such, cant establish cause, added to which it relied on personal recall and included data from a single point in time. Specific details on training intensity, training load, volume (sets and repetitions), and for how long participants had been exercising with weights werent available, all of which may have influenced the findings.

The study focused only on weights, but there are other types of muscle strengthening exercise, say the researchers, citing callisthenics, which include push-ups and squats; Pilates; and plyometric exercises, which include tuck jumps and burpees.

Using weights can make a body leaner: total lean mass is independently associated with a lower risk of death, say the researchers by way of an explanation for their findings. And if done in a gym, could also be very sociableanother factor associated with a longer, healthier life.

Our finding that mortality risk appeared to be lowest for those who participated in both types of exercise provides strong support for current recommendations to engage in both aerobic and muscle-strengthening activities, they write.

Older adults would probably benefit from adding weightlifting exercises to their physical activity routines, they conclude.

Author: BMJ Media RelationsSource: BMJContact: BMJ Media Relations BMJImage: The image is in the public domain

Original Research: Closed access.Independent and joint associations of weightlifting and aerobic activity with all-cause, cardiovascular disease and cancer mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial by Charles E Matthews et al. British Journal of Sports Medicine

Abstract

Independent and joint associations of weightlifting and aerobic activity with all-cause, cardiovascular disease and cancer mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Objectives

Both aerobic moderate to vigorous physical activity (MVPA) and muscle-strengthening exercise (MSE) are recommended, but the mortality benefits of weightlifting, a specific type of MSE, are limited.

Methods

In the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we used Cox proportional hazards regression to calculate hazard ratios (HRs) and 95% CIs for the associations between weightlifting and mortality, adjusting for demographics, lifestyle and behavioural risk factors. The sample included 99713 adults who completed the follow-up questionnaire that assessed weightlifting who were subsequently followed up through 2016 to determine mortality (median 9, IQR 7.610.6 years).

Results

Mean age at the follow-up questionnaire was 71.3 (IQR 6676) years, 52.6% female, with mean body mass index of 27.8 (SD 4.9) kg/m2. Weightlifting was associated with a 9% lower risk of all-cause mortality (HR=0.91 (95% CI 0.88 to 0.94)) and CVD mortality (0.91 (95% CI 0.86 to 0.97)) after adjusting for MVPA. Joint models revealed that adults who met aerobic MVPA recommendations but did not weightlift had a 32% lower all-cause mortality risk (HR=0.68 (95% CI 0.65 to 0.70)), while those who also reported weightlifting 12times/week had a 41% lower risk (HR=0.59 (95% CI 0.54 to 0.64)), both compared with adults reporting no aerobic MVPA or weightlifting. Without adjustment for MVPA, weightlifting was associated with lower cancer mortality (HR=0.85 (95% CI 0.80 to 0.91)).

Conclusion

Weightlifting and MVPA were associated with a lower risk of all-cause and CVD mortality, but not cancer mortality. Adults who met recommended amounts of both types of exercise appeared to gain additional benefit.

See the original post here:
Regularly Exercising With Weights Linked to Lower Risk of Death - Neuroscience News

Long-Term Study Supports Link Between Inflammation and Cognitive Problems in Older Breast Cancer Survivors – Neuroscience News

Summary: Higher levels of the inflammatory C-reactive protein were discovered in older breast cancer survivors who experienced cognitive issues. The study is one of the first long-term assessments linking chronic inflammation to cognitive decline in breast cancer survivors.

Source: UCLA

Scientists are still trying to understand why many breast cancer survivors experience troubling cognitive problems for years after treatment. Inflammation is one possible culprit.

Anew long-term studyof older breast cancer survivors published today in theJournal of Clinical Oncologyand co-led by UCLA researchers adds important evidence to that potential link.

Higher levels of an inflammatory marker known as C-reactive protein (CRP) were related to older breast cancer survivors reporting cognitive problems in the new study.

Blood tests for CRP are used routinely in the clinic to determine risk of heart disease. Our study suggests this common test for inflammation might also be an indicator of risk for cognitive problems reported by breast cancer survivors, said study lead author Judith Carroll, an associate professor of psychiatry and biobehavioral sciences and faculty member of the Cousins Center for Psychoneuroimmunology at UCLA and the UCLA Jonsson Comprehensive Cancer Center.

The study, called the Thinking and Living with Cancer (TLC) Study, is one of the first long-term efforts to examine the potential link between chronic inflammation and cognition in breast cancer survivors 60 and older, who make up a majority of the nearly 4 million breast cancer survivors in the United States.

Previous research has focused largely on younger women and women immediately after therapy, making it difficult to draw conclusions about CRPs role in long-term cognitive problems among older breast cancer survivors.

In TLC, teams of researchers from around the country talked to, and obtained blood samples from, hundreds of breast cancer survivors and women without cancer up to 6 times over the course of 5 years. The study was motivated by hearing from survivors and advocates that cognitive problems are one of their major worries.

Cognitive issues affect womens daily lives years after completing treatment, and their reports of their own ability to complete tasks and remember things was the strongest indicator of problems in this study, said co-senior study author Dr. Jeanne Mandelblatt, a professor of oncology at Georgetown University who is the lead of the TLC study.

Being able to test for levels of inflammation at the same time that cognition was being rigorously evaluated gave the TLC team a potential window into the biology underlying cognitive concerns, said Elizabeth C. Breen, a professor emerita of psychiatry and biobehavioral sciences at the Cousins Center for Psychoneuroimmunology at UCLA, who also served as co-senior study author.

Cognition, from the perspective of each woman, was evaluated through a commonly used questionnaire assessing how the women perceive their ability to remember things like names and direction, ability to concentrate, and other aspects of everyday life.

The study found higher CRP levels among survivors were predictive of lower reported cognitive function among breast cancer survivors. There was no similar relationship between CRP levels and reported cognition in the women without cancer.

Cognitive performance, as measured by standardized neuropsychological tests, failed to show a link between CRP and cognition. The authors say this may indicate women are more sensitive to differences in their everyday cognitive function, self-reporting changes that other tests miss.

The authors said their study supports the need for research on whether interventions that can lower inflammation including increased physical activity, better sleep, and anti-inflammatory medications may prevent or reduce cognitive concerns in older breast cancer survivors.

Other study authors include Zev M. Nakamura, Brent J. Small, Xingtao Zhou, Harvey J. Cohen, Tim A. Ahles, Jaeil Ahn, Traci N. Bethea, Martine Extermann, Deena Graham, Claudine Isaacs, Heather S.L. Jim, Paul B. Jacobsen, Brenna C. McDonald, Sunita K. Patel, Kelly Rentscher, James Root, Andrew J. Saykin, Danielle B. Tometich, Kathleen Van Dyk, and Wanting Zhai. The authors declared no conflicts of interest.

Author: Jason MillmanSource: UCLAContact: Jason Millman UCLAImage: The image is in the public domain

Original Research: Closed access.Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study by Judith Carroll et al. Journal of Clinical Oncology

Abstract

Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study

PURPOSE

To examine longitudinal relationships between levels of C-reactive protein (CRP) and cognition in older breast cancer survivors and noncancer controls.

METHODS

English-speaking women age 60 years, newly diagnosed with primary breast cancer (stage 0-III), and frequency-matched controls were enrolled from September 2010 to March 2020; women with dementia, neurologic disorders, and other cancers were excluded. Assessments occurred presystemic therapy/enrollment and at annual visits up to 60 months. Cognition was measured using the Functional Assessment of Cancer Therapy-Cognitive Function and neuropsychological testing. Mixed linear effect models tested for survivor-control differences in natural log (ln)-transformed CRP at each visit. Random effectlagged fluctuation models tested directional effects of ln-CRP on subsequent cognition. All models controlled for age, race, study site, cognitive reserve, obesity, and comorbidities; secondary analyses evaluated if depression or anxiety affected results.

RESULTS

There were 400 survivors and 329 controls with CRP specimens and follow-up data (average age of 67.7 years, range: 60-90 years). The majority of survivors had stage I (60.9%), estrogen receptorpositive (87.6%) tumors. Survivors had significantly higher adjusted mean ln-CRP than controls at baseline and 12-, 24-, and 60-month visits (allP< .05). Higher adjusted ln-CRP predicted lower participant-reported cognition on subsequent visits among survivors, but not controls (Pinteraction = .008); effects were unchanged by depression or anxiety. Overall, survivors had adjusted Functional Assessment of Cancer Therapy-Cognitive Function scores that were 9.5 and 14.2 points lower than controls at CRP levels of 3.0 and 10.0 mg/L. Survivors had poorer neuropsychological test performance (vcontrols), with significant interactions with CRP only for the Trails B test.

CONCLUSION

Longitudinal relationships between CRP and cognition in older breast cancer survivors suggest that chronic inflammation may play a role in development of cognitive problems. CRP testing could be clinically useful in survivorship care.

Continued here:
Long-Term Study Supports Link Between Inflammation and Cognitive Problems in Older Breast Cancer Survivors - Neuroscience News

Yale’s application-based majors have dwindled in recent years – Yale Daily News

Zoe Berg, Senior Photographer

Few majors at Yale require an application. Even those that have kept theirs are no longer competitive.

For the last decade, the College has required students interested in many popular fields to apply into their majors, often during their sophomore year. But the News review of application-based majors and academic offerings found that the prevalence of Yale Colleges competitive majors has dwindled in recent years.

Notably, the popular Ethics, Politics, and Economics major jettisoned its application process in favor of an extended prerequisite system two years ago; neuroscience followed suit last April.

We are committed to supporting world-shaping research and life-changing instruction in areas of intellectual importance, Dean of the Faculty of Arts and Sciences Tamar Gendler said. I am pleased that we are in a position to give students the opportunity to study in these important majors without requiring an application process.

There are now just four majors that require applications: architecture, cognitive science, global affairs, and the special divisional major. Faculty at all four say they intend to keep their application processes for the time being, but they, too, have considered changes. And none of them remain truly competitive.

When the College added the Global Affairs major in 2010, admission was capped at 50. But surging demand meant that in 2011, just one-third of students who applied were accepted.

Now, over a decade later, admission is no longer so cutthroat. Decisions are based almost entirely on whether students are on track to finish the major before they graduate.

In the last two years, 80 to 90 percent of students who applied were able to do the major, if not more, said Sigrdur Benediktsdottir, the Director of Undergraduate Studies for Global Affairs. I dont think we rejected anyone that would have been able to fulfill the requirements of the major.

Grades, Benediktsdottir said, did not factor into admissions decisions except in cases when students withdrew from or used the Credit/D/Fail option on core classes of the major. Those who were rejected were likely not to have completed enough core courses or to have taken a modern language through L5.

The application has a written component, too, but this year it has been shortened from two questions to one, which students will be asked to answer in 600 words or fewer.

We are not requesting students to spend a lot of time on this, Benediktsdottir said. We just want to know why they want to be in the major.

There will be two information sessions for students interested in GLBL one on Oct. 28 and one on Nov. 2 after which the application will open. The deadline to apply will be Friday, Nov. 18, just before the start of November recess.

After this application cycle, though, the deadline for sophomores to apply will be about two months earlier than it is now; instead of November, the due date will likely be at the end of September. Sophomores will therefore know whether they have been accepted into the major before spring course registration begins.

So, essentially, you will be applying based on what you do your freshman year and what courses youve signed up for during your sophomore fall, Benediktsdottir said. Next year, we are planning to let students know whether they are in the major before spring course registration begins.

While enrollment in the global affairs major has seen only a modest increase in the past few years perhaps on account of its application process enrollment in EP&E has significantly increased since scrapping its application.

The class of 2022, the last application-only class, had 35 graduating seniors. The class of 2024, by comparison, has 48 majors so far.

We are confident that the EP&E major will continue to yield excellent cohorts of students each year, attracted to EP&E by its interdisciplinary approach and high academic rigor, said EP&E Program Director Ana De La O.

Reduced barriers of entry might be responsible for this increased enrollment. While students previously needed to apply and be accepted to EP&E, anyone who completes the eight prerequisite courses can now declare the major.

Ryan Smith 24, an EP&E major, said that he was glad that EP&E switched to a prerequisite system.

There are a lot of prerequisites, but its reassuring to know that as long as you complete them youll get into the major, Smith said. None of us need another application to worry about.

EP&E has been able to increase its enrollment commensurate with student interest, but architecture has not changed its enrollment cap.

The architecture major currently has two tracks: Design and History, Theory & Criticism. Only the design track is effectively selective, though all prospective majors must apply to a specific track in the spring of their sophomore year.

Based in a four-semester sequence of studios, Design is a space- and resources-intensive course of study, architecture Director of Undergraduate Studies Michael Schlabs wrote in an email to the News. Every student enrolled has a desk on the 7th floor of Rudolph Hall, a computer workstation and a shared modeling table for this reason, we are compelled to cap the Design track of the architecture major at 40 students or 20 per year across the junior and senior classes.

Though the major has rarely, if ever, hit the 20-student-per-year limit, the enrollment cap might soon increase.

The School of Architecture is reluctant to make any immediate changes, though.

With the influx of graduate Architecture students returning from pandemic-related leaves of absence, we are especially cramped in the School of Architecture [right now], Schlabs told the News. Having said that, we have recently been in conversation with the Yale College Committee on Majors about precisely this issue, and we will be revisiting the question of selectivity in the major in a couple years, once the COVID bulge in student population subsides.

Neuroscience, too, has taken steps to ensure its students have the resources they need.

When Yale College added the neuroscience major in 2018, student interest was very high and the program very new, so an application seemed in order.

When the neuroscience major began several years ago, we had a simple application process, which we put in place to ensure we had the resources to support all the students in the major, neuroscience Director of Undergraduate Studies Damon Clark wrote in an email to the News.

Now, though, the program has grown to accommodate more students, and an application is no longer necessary. As of April 2022, students can declare the major as they can any other.

By contrast, cognitive science and the special divisional major have kept their applications for the time being.

According to its website, cognitive science requires interested students to apply to the major by the end of fall semester. Students must then be accepted before officially declaring their major.

The cognitive science program is a bit unique, in that the requirements are extremely flexible, cognitive science Director of Undergraduate Studies Joshua Knope wrote in an email to the News. Its not as though there is already a pre-set list of requirements Instead, students have the opportunity to craft their own list of requirements based on their own individual interests.

The cognitive science application essentially functions as a roadmap proposal how a particular student wants to take on the major.

But if a proposal is not accepted, that does not mean the student needs to switch majors.

It just means that you will not be allowed to use that specific plan, Knope wrote. You could apply again the very next day with a different plan.

The special divisional major which allows students to pursue fields of study outside of Yales existing majors also has an application, though it is reviewed by the Committee on Honors and Academic Standing instead of by an individual department or program.

The special divisional major application asks students to explain their proposed plan of study, including coursework contributing toward the major; to outline the majors curricular trajectory, breadth and depth; and to give a broad sense of intellectual aims, Special Divisional Major Director of Undergraduate Studies Sarah Mahurin wrote in an email to the News.

The application also asks students to identify faculty members who will serve as their advisers. The faculty members must likewise write in support of the proposal.

Special divisional major, neuroscience and cognitive science do not intend to change their application processes in the immediate future.

Yale College currently offers 80 different majors.

Evan Gorelick covers Woodbridge Hall with a focus on the Yale Corporation, endowment and Provost's Office. He is a Production and Design Editor and previously covered faculty and academics at the News. Originally from Woodbridge, Connecticut, he is a sophomore in Timothy Dwight College double-majoring in English and economics.

Link:
Yale's application-based majors have dwindled in recent years - Yale Daily News

Potential Therapeutic Targets to Prevent Hearing Loss Caused by Antibiotics – Neuroscience News

Summary: Researchers have identified an autophagy pathway in hair cells in the ear thats linked to permanent hearing loss that occurs as a result of exposure to aminoglycosides antibiotics in some patients.

Source: Indiana University

Researchers at Indiana University School of Medicine are developing new ways to study why an antibiotic causes hair cell death and permanent hearing loss in people.

In astudy recently published inDevelopmental Cell, the researchers explained how they identified the autophagy pathway in hair cells thats linked to permanent hearing loss brought about by aminoglycosidesa class of antibiotics.

The researchers also developed one of the first laboratory models thats insusceptible to aminoglycoside-induced hearing loss.

This work identifies multiple potential therapeutic targets for preventing hearing loss caused by aminoglycosides, saidBo Zhao, PhD, assistant professor of otolaryngologyhead and neck surgery.

Ototoxicityhearing loss caused by medicationis one of the main causes of hearing loss in humans. More than 48 million people in the United States experience trouble hearing.

Aminoglycosides for nearly a century have been used to treat severe infections. Although the drug is a first-line treatment for life-threatening infectionsparticularly in developing countriesdue to their low cost and low incidence of antibiotic resistance, it has been reported to cause hair cell death and subsequent permanent hearing loss among 20-47% of patients, but the underlying mechanisms are not clear. Hair cells are responsible for sound reception in the inner ear.

Zhao, whose lab investigates the molecular mechanisms underlying hearing loss, used biochemical screening to identify proteins found in hair cells. They first discovered that aminoglycosides bound to the protein RIPOR2, which is required for auditory perception.

As aminoglycosides specifically trigger a rapid localization change of RIPOR2 in hair cells, we hypothesize that RIPOR2 is essential for aminoglycoside-induced hair cell death, Zhao said.

The researchers developed a model in the lab that has normal hearing but significantly decreased RIPOR2 expression. Through these experiments, Zhao said the model had neither significant hair cell death nor hearing loss after treatment of aminoglycosides.

We then discovered RIPOR2 regulates the autophagy pathway in hair cells. Knowing this, we developed other laboratory models without the expression of several key autophagy proteins that did not exhibit hair cell death or hearing loss when treated with the antibiotic, saidJinan Li, PhD, postdoctoral fellow in the Zhao lab and first author of the paper.

The study authors say the proteins identified in this study could potentially be used as drug targets to prevent aminoglycoside-induced hearing loss in future studies.

In addition to Zhao and Li, authors of the article includeChang Liu, PhD, postdoctoral fellow in the Zhao lab, andUlrich Mueller, PhD, Bloomberg Distinguished Professor of Neuroscience and Biology at Johns Hopkins University. Funding for the research was provided by the National Institutes of Health and IU School of Medicine.

Author: Christina GriffithsSource: Indiana UniversityContact: Christina Griffiths Indiana UniversityImage: The image is in the public domain

Original Research: Closed access.RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss by Bo Zhao et al. Developmental Cell

Abstract

RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss

Aminoglycosides (AGs) are potent antibiotics that are capable of treating a wide variety of life-threatening infections; however, they are ototoxic and cause irreversible damage to cochlear hair cells.

Despite substantial progress, little is known about the molecular pathways critical for hair cell function and survival that are affected by AG exposure.

We demonstrate here that gentamicin, a representative AG antibiotic, binds to and within minutes triggers translocation of RIPOR2 in murine hair cells from stereocilia to the pericuticular area.

Then, by interacting with a central autophagy component, GABARAP, RIPOR2 affects autophagy activation. Reducing the expression of RIPOR2 or GABARAP completely prevents AG-induced hair cell death and subsequent hearing loss in mice.

Additionally, abolishing the expression of PINK1 or Parkin, two key mitochondrial autophagy proteins, prevents hair cell death and subsequent hearing loss caused by AG. In summary, our study demonstrates that RIPOR2-mediated autophagic dysfunction is essential for AG-induced hearing loss.

See the original post here:
Potential Therapeutic Targets to Prevent Hearing Loss Caused by Antibiotics - Neuroscience News

Dan the Man: Meet the manager of OUWB’s Anatomy Lab, medical students’ ‘first patients’ – News at OU

Oakland University William Beaumont School of Medicine students always remember their first patient and since the schools launch, Dan Schlegel has had a key role in those relationships.

The reason?

Schlegel has managed OUWBs Anatomy Lab since its start in 2011.

He is responsible for taking care of the lab and the donors in this context, that primarily means people who made a pre-death decision to donate their respective bodies to science so that medical students can study and truly understand structures within the human body.

Its a unique job that Schlegel says generally elicits one of two reactions.

People are either super interested and ask a lot of questions, he says with a smile. Or they just kind of back away slowly.

Regardless, Schlegel says he never forgets what the job is really all about.

For me, its all about working with the students and faculty to help build future doctors, he says.

Those who work closest with Schlegel say his commitment to the role is evident.

Dan does an exceptional job, says Malli Barremkala, associate professor, Department of Foundational Medical Studies and director of OUWBs Body Donation Program.

Over the years he has been instrumental in the support of the anatomy programs at OUWB, and we affectionately call him Dan the Man.

I was a little tentative

In his managerial role, Schlegel works directly with OUWB faculty to ensure students have what they need when it comes to studying anatomy in the lab. Additionally, he supports Oakland University physical therapy programs, which also use the lab.

His responsibilities not only include moving and preparing donors, but ensuring students have all of the equipment they need, that the entire space is maintained and held to the highest standards of cleanliness, and that all rules are followed. For example, students are prohibited from taking pictures in the lab.

Schlegel says his daily work in the lab is guided by two principles: the important role the donors play in helping students learn, and the need to maintain respect.

Donors essentially donate themselves before deaththey give everything that they are to educate students, he says. We respect donors as patientsjust because they cant hear you or respond doesnt mean we treat them less.

Of course, the big question is: how does one become manager of a medical school anatomy lab?

For Schlegel, it started when he was an undergrad at Oakland University, pursuing a bachelors degree in health sciences.

During that time, in the mid-2000s, Schlegel had his first experience with donors. It was different from the experience that medical students have because the anatomic specimens were prosected (already dissected by more experienced anatomists).

Still, the experience helped build his comfort level of working with body donors. The fact that he has always been science-minded further helped.

As a student, I was a little tentative the first time they pulled out the donors in that first lab classbut I was never really squeamish, he says. I was more interested in learning how things worked.

Soon, Schlegel was helping others learn how things work as a teaching assistant for Mary Bee, Ph.D., associate adjunct associate professor, School of Health Sciences.

When presented with the opportunity to join OUWB in 2011, he jumped at the chance.

It was a month before OUWB welcomed its charter class of 50 students.

Theyre even more comfortable

For the first two classes, OUWBs anatomy lab was in the basement of Oakland Universitys Mathematics and Science Center. Schlegel said the situation was less-than-ideal as the space did not have windows, the loading dock was across the hall, there was lackluster ventilation, and other issues existed.

Among the biggest, he said, was that the donors had to be moved every time there was a class.

All of that changed in 2013, when the lab was relocated to the third floor of Oakland Universitys Hannah Hall following a complete remodeling of the space that now houses the anatomy lab.

The restricted lab now features 37 tables specifically for donors, each equipped with a special ventilation system and computer. The size and the layout of the lab allows students to move freely and not feel crammed into a tiny space. Windows line the walls, creating a bright atmosphere.

Schlegel says his favorite part of the job is seeing the evolution of students with regard to how they approach donors.

At the beginning of the semester, some of the students can be pretty (hesitant), but by the end of the semester they are totally immersed, he says. Then they come back for the second semester and theyre even more comfortable.

Having an OU alum run the lab is beneficial, says Barremkala.

He has knowledge of the OU campus and facilities and he uses this effectively for a well-functioning lab, he says.

Schlegel also goes above and beyond to help keep students on track.

Dan was one of the very few employees that worked in-person throughout the pandemic and played a key role in delivery of the lab component of the AFCP (Anatomical Foundations of Clinical Practice) course, says Barremkala.

Looking ahead, Schlegel says he is excited that OUWB recently started its own body donor program. So far, OUWB has worked with other institutions like University of Toledo to obtain donor bodies, which are then given back to the school at the end of the year for proper cremation and return to the family.

Well have more control over the embalming process, selection criteria of the donors, and direct contact with the families, which makes it a little easier to get necessary medical records, he says. Its really exciting.

For more information, contact Andrew Dietderich, marketing writer, OUWB, at adietderich@oakland.edu.

To request an interview, visit the OUWB Communications & Marketingwebpage.

NOTICE: Except where otherwise noted, all articles are published under aCreative Commons Attribution 3.0 license. You are free to copy, distribute, adapt, transmit, or make commercial use of this work as long as you attribute Oakland University William Beaumont School of Medicine as the original creator and include a link to this article.

Follow OUWB onFacebook,Twitter, andInstagram.

Read this article:
Dan the Man: Meet the manager of OUWB's Anatomy Lab, medical students' 'first patients' - News at OU

What is the largest organ in the body? Skin versus liver, explained. – USA TODAY

Your anatomy operates like a machine, it's success hinging on the work of over 70 organs, each with a unique function. From the heart's blood pumping ability, to the liver's filtering power, each component of the human ecosystem forms anintegral part of the larger machinery.

To break down our food, to regulate sugar, to ward off the toxins of the outside world, our bodies depend onorgans to ensure survival.But, which organ is the biggest? How about the smallest? Can you live without some of your organs?

Take a deeper look inside your own anatomy with the answers to these questions,plus a few bonus facts about your bones and muscles, organs' helpful counterparts.

Organ transplant milestone:As US crosses 1 million mark, advances offer hope for millions more

Organs from the animal world: First-ever pig-to-human heart transplant offers hope for thousands in need of organs

The skin is the largest organ in the body. It is an external rather than an internal organ.

According to National Geographic, the average adult carries around 8 pounds and 22 square feet of skin on their body.

Yes, the skin is an organ, the largest.

It can seem counterintuitive since many of our other organs are unseen. The skin,made up of three layers: the Epidermis, the Dermisand the Hypodermis, is an external organ. It serves as a very important barrier between the body and bacteria, chemicals, and temperature.

Treat your skin right: Want smooth, glowing skin all over? Add these body products into your routine

Healthline reports thatthe top five largest organs in the human body are:

The liver is the bodys largest solid, internal organ. In the upper right part of your abdomen, the liver is your body's filtration system.

It filters toxins out of the blood and produces protein for blood plasma. The liver also produces bile, a product which helps to move waste and break down fats in the small intestine during digestion.

It is a dark brown/red and weighs in at approximately 3 pounds.

To date, there are 79 generally recognized organs in the human body, both internal and external.

This is not a question with a direct answer, as strength has many different measures.

Based on weight, the Library of Congress reports that the strongest muscle in the body is the Masseter. It is one of the four muscles responsible for chewing.

The largest muscle in the human body is the Gluteus Maximus. It is responsible for keeping your posture upright, and is the principal antigravity force working when you walk up stairs.

Other strong muscles include the tongue, heart, uterine muscles, external eye muscles, and Soleus(a muscle found just below the calf).

Get your muscles right: Workouts for each fitness goal, from weight loss to finding your abs

The femur.

It is the longest and strongest bone in your body. The femur is your thigh bone, running from your knee to your hip. Its a difficult bone to break, but if you do, youll likely need surgery.

The pineal gland. It is an incredibly small endocrine gland found in the brain that regulates your circadian rhythm (sleep pattern) by releasing melatonin.

This ever so small organ is shaped like a tiny pinecone, hence the name pine-al gland.

There are 8 blood types, made from four different blood groups A, B, AB, and O. Your genetic makeup determines which blood group you will fall into.

Each of these letters or letter combos can be either RhD positive or negative, making the 8 total types:

What is the most common blood type?: Here's which of the eight is most (and least) common.

It may spark some confusionthat arteries, though a category unto themselves, can be organs as well. The arteries are a critical component of the cardiovascular system, pumping oxygenated blood to the rest of your body.

Artery is the specific term used for this type of blood vessel. Organ is a more broad term that is used to describe a group of tissues that structurally form a functioning, specialized unit of the human anatomy.

Since arteries are made up of tissue, and have a specialized function, they can be classified as organs.

Beta-cells are responsible for the production of insulin, and then subsequently storing that insulin and secreting it when needed based on concentration levels of glucose and fatty acids in the body.

The human body can feasibly operate without a number of different organs. According to Insider, that list includes:

Of note, some of these organs can be removed without much modification while others require regular medical treatments or adjustments to make a healthy life in their absence feasible.

Just Curious?: Your everyday questions, answered.

Continued here:
What is the largest organ in the body? Skin versus liver, explained. - USA TODAY

What Happened To Sara Ramirez After Leaving Grey’s Anatomy? – Looper

After leaving "Grey's Anatomy" in 2016, Sara Ramirez continued their career as an actor. Their first significant role after "Grey's" was their main role as Kat Sandoval in the political drama "Madam Secretary" for the show's fourth and fifth seasons from 2017 to 2019 (via IMDb). Additionally, from 2012 to 2018, Ramirez voiced the role of Queen Miranda in the animated children's series "Sofia the First."

A couple of years after "Madam Secretary" ended, Ramirez landed another leading role on the highly anticipated HBO Max sequel series to "Sex and the City," titled "And Just Like That ..." In the series, Ramirez plays Che Diaz, a nonbinary queer comedian who hosts a podcast alongside Carrie Bradshaw (Sarah Jessica Parker). After being introduced to Miranda Hobbes (Cynthia Nixon) by Carrie, the two begin a romance even though Miranda is still married. By the end of the series, Miranda has left her marriage and has decided to move to Los Angeles with Che.

Read more from the original source:
What Happened To Sara Ramirez After Leaving Grey's Anatomy? - Looper

ABC Fall 2022 Premiere Dates for Grey’s Anatomy, Station 19, The Rookie: Feds, and More – TV Guide

ABC kicked off fall TV season with the return of its comedy shows, debuting new episodes of The Conners, The Goldbergs, Home Economics, and newly minted Emmy-winnerAbbott Elementary. And though dramaBig Skyreturned for a third season, with Jensen Ackles joining the cast as the charming potential love interest who steps in as temporary sheriff, the bulk of ABC's fall TV lineup has yet to premiere.

Sunday, Sept. 25 marks the debut of two new game shows: Celebrity Jeopardy! and Celebrity Wheel of Fortune. Those will be followed by the Nathan Fillion-starring LAPD crime dramaThe Rookie, back for a fifth season. That show's brand new spin-off The Rookie: Feds starring Niecy Nash, premieres Tuesday Sept. 27 afterBachelor in Paradise. The network's most popular dramas Grey's Anatomy,Station 19, andThe Good Doctor won't premiere until October. ABC's fall TV premiere schedule culminates in the debut of the newHilary SwankdramaAlaska Daily.

See the complete list of ABC's 2022 fall TV premiere dates below,check out trailers for the new shows, and see the full2022 fall TV premiere date schedulefor new and returning shows across all networks.

Caterina Scorsone and Kelly McCreary,Grey's Anatomy

Wednesday, Sept. 218 p.m.: The Conners Season 58:30 p.m.: The Goldbergs Season 109 p.m.: Abbott Elementary Season 29:31 p.m.: Home Economics Season 310 p.m.: Big Sky Season 3

Friday, Sept. 238 p.m.: Shark Tank Season 149:01 p.m.: 20/20 (two hours)

Sunday, Sept. 258 p.m.: Celebrity Jeopardy! NEW SERIES9 p.m.: Celebrity Wheel of Fortune Season 310 p.m.: The Rookie Season 5

Tuesday, Sept. 278 p.m.: Bachelor in Paradise Season 810 p.m.: The Rookie: Feds NEW SERIES

Sunday, Oct. 27 p.m.: America's Funniest Home Videos Season 33

Monday, Oct. 38 p.m.: Bachelor in Paradise new episode10 p.m.: The Good Doctor Season 6

Thursday, Oct. 68 p.m.: Station 19 Season 69 p.m.: Grey's Anatomy Season 1910 p.m. Alaska Daily NEW SERIES

Follow this link:
ABC Fall 2022 Premiere Dates for Grey's Anatomy, Station 19, The Rookie: Feds, and More - TV Guide

Anatomy of a Night review: Joyous, sexy, infectious, seductive – The Irish Times

Anatomy of a NightThe Depot, The Complex

Hows your night going? In the Complexs splendid new cavernous performance space, Kevin Murphys striking lighting, Sal Stapletons videography, Rory Sweeneys sound design with music by a different DJ each night and a catwalk pushing through the audience all delineate the club.

Aiming to evoke a night, any night, in queer and club spaces, the dancer and choreographer Nick Nikolaou does it solo, serially creating a cast. His queers, weirdos, fringes and nightwalkers are expressed by their efficiently changed costumes-with-attitude (designed by Dearbhla Beirne): striding down the catwalk preening in thigh boots, bustier and half-ball gown, or out of it in a sparkly slip dress, an uncertain lurker in a shirtless suit with something to prove, or writhing and oozing sex, or muscular anthems in a tight jumpsuit.

Nikolaou creates multiple characters through an energising, skilful, perfectly observed and sometimes dizzying range of club dance styles. Joyous, sexy, infectious and seductive, Anatomy of a Night is also tinged with regret for something lost lost to the pandemic and lost to the citys absence of clubbing spaces. After the performance, theres a club night for the audience.

Runs at the Complex, Dublin 7, until Saturday, September 24, as part of Dublin Dance Festival

Go here to read the rest:
Anatomy of a Night review: Joyous, sexy, infectious, seductive - The Irish Times