Many diverse nanopore research directions and applications beyond DNA sequencing – News-Medical.Net

In a recent Nature Nanotechnology study, researchers describe diverse applications of nanopore-based technology beyond deoxyribonucleic acid (DNA) sequencing. More specifically, the current research focuses on the advancements of this technology within chemistry, biophysics, and nanoscience.

Study:Nanopore-based technologies beyond DNA sequencing. Image Credit: Yurchanka Siarhei / Shutterstock.com

In a conventional application, analytes of interest will enter the nanopore under an applied current that changes the flow of ions through the nanopore. This change in ion flow is reflected as a time-dependent current recording that can be used to sense and characterize various biomolecules such as DNA, RNA, proteins, peptides, metabolites, and protein-DNA complexes at the molecular level.

The type of nanopore employed for a given study depends upon the analyte of interest, as both the nanopore and analyte dimensions should be comparable to produce a recordable change in ionic current.

Biological nanopores, for example, can recognize biomolecules with diameters within the range of -1 to 10 nanometers (nm). Comparatively, solid-state nanopores are used for optical applications, including electron/ion million, laser-based optical etching, and the dielectric breakdown of ultrathin solid membranes.

Although nanopores were initially developed for sensing ions and small molecules, particularly for DNA sequencing purposes, the applications of this technology have expanded considerably.

Some of the key advantages of nanopores that have contributed to their widespread application include their ability to capture single molecules consecutively and at a rapid rate, convert both the structural and chemical properties of analytes into a measurable ionic current, and identify label-free species for signal amplification.

Solid-state nanopores can help extract the generic properties of proteins, such as volume, dipole, and shape. In addition, ligands, such as biotin, aptamers, protein domains, or antibodies, can directly attach to biological nanopores, even in the presence of complex media, such as serum.

In addition to identifying proteins, nanopores can act as single-molecule sensors to provide information on proteins' activity, dynamics, and conformational changes. By trapping a protein inside of a biological nanopore, for example, researchers can obtain information on the proteins conformational changes and dynamics as it remains within the nanopore.

Although nanopores cannot provide information on the activities of individual enzymes, they may be able to monitor the formation of products following enzymatic reactions, mainly when conventional spectroscopic assays are unavailable.

Biological nanopores engineered to contain reactive sites are referred to as protein nanoreactors. These specific nanopores could assist in the analysis of bond-making and bond-breaking events of individual molecules attached to the interior wall of a nanopore as it modulates the ionic current. Additional applications of nanoreactors include the analysis of phytochemistry, stereochemical transformations, polymerization steps, and a primary isotope effect.

Cells feature several nm-sized pores within their membranes that act as gateways for molecular transport between cell compartments. To better understand the mechanisms involved in the transport of biomolecules through these pores, they could be extracted from the cell and docked within planar lipid membranes. Unfortunately, this reconstitution approach is extremely difficult; thus, nanopores offer exciting opportunities to study cell biology.

Various engineered nanopore-based systems can mimic biological pores in vitro, such as asymmetric solid-state nanopores, which could mimic switchable ion channels to study ion pumps and ion- and pH-gated pores. In addition, synthetic DNA origami pores can also be used to mimic ligand-gated ion channels, whereas biological nanopores can be designed to mimic passive or active membrane transporters.

The nuclear pore complex (NPC), a larger pore that regulates the transportation of proteins and RNAs between cellular compartments, may also be studied through biomimetic NPCs. Although considerable information is available on the biological function of NPCs, biomimetic NPCs can be used to better understand the specific transport properties of these biological pores.

Analyzing the presence of specific biomarkers within biomedical samples, such as bodily fluids, tissue biopsies, or other biological specimens, such as viruses, bacteria, and cell cultures, is associated with numerous challenges.

For example, target biomolecules within samples, many of which are nucleic acids or proteins, can be present in concentrations ranging from tens of attomolar (1018M) to the subnanomolar (109M) range. In addition, such clinical samples also comprise various other biomolecules that may interfere with the nanopore sensor itself.

To overcome these limitations, various smart bioassays and devices utilizing nanopore sensing technology have been developed to analyze clinical samples. For example, novel microfluidic devices integrated with nanopore sensors can potentially be used for sample preparation or detecting analyte concentration levels.

Furthermore, specific biochemical assays based on biological nanopores can enhance molecular specificity while simultaneously eliminating unwanted interactions from background molecules. This approach can also reduce the loss of targeted molecules during sample preparation while ensuring that the nanopore is protected against any potential degradation from surrounding biomolecules.

With nanopore design improvements, these technologies will continue to evolve and address scientific challenges. Moreover, researchers anticipate that nanopores will find novel applications in a wide range of areas, from molecular sensing and sequencing to chemical catalysis and biophysical characterization.

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Live-Cell Imaging Market Size And Forecast To 2022 |GE Healthcare, Olympus Corporation, Danaher Corporation, Thermo Fisher Scientific Inc., Sartorius…

In a report currently being published by Verified Market Research titled GlobalLive-Cell Imaging Market Size, Manufacturers, Supply Chains, Sales Channels and Customers, 2022-2029, analysts presented a detailed overview of the Live-Cell Imaging market. The report is a comprehensive study of Live-Cell Imaging global markets, taking into account growth factors, recent trends, events, opportunities and the competitive environment. Market analysts and researchers conducted an extensive analysis of the Global Live-Cell Imaging Market, using research methodologies such as the analysis of the five strengths of PESTLE and Porter. They provided accurate and reliable market data and useful recommendations to help participants better understand the overall scenario of the current and future market. The report includes an in-depth study of potential segments, including the type of product, Application and end user, as well as their contribution to the overall market size.

Highlight

Live-Cell Imaging Market size was valued at USD 2.36 Billion in 2020 and is projected to reach USD 4.24 Billion by 2028, growing at a CAGR of 7.47% from 2021 to 2028.

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Scope of the report

This report aims to provide a comprehensive view of the Global Live-Cell Imaging Market, with quantitative and qualitative analysis to help readers develop business/growth strategies, assess the competitive market situation, analyze their current market position and make informed business decisions regarding Live-Cell Imaging.

The size, estimates and forecasts of the Live-Cell Imaging market are presented in terms of revenue (in millions of US dollars), taking into account 2021 as the base year, with historical and forecast data for the period from 2017 to 2028. This report comprehensively segments the Global Live-Cell Imaging Market. Regional market sizes related to products by type, applications and participants are also presented. The impact of COVID-19 and the Russian-Ukrainian war was taken into account when assessing the size of the markets.

For a deeper understanding of the market, the report presents profiles of the competitive environment, the main competitors and their respective positions in the market. The report also examines technological trends and new product developments.

The report will help Live-Cell Imaging companies, newcomers and companies associated with the industry chain in this market to provide revenue information for the entire market and sub-segments of various segments by company, product type, application and region.

Key companies and market share

In this section, readers will get acquainted with the main participants of the competition. This report examined key growth strategies such as innovation trends and developments, product range expansion, mergers and acquisitions, collaboration, innovation in new products and geographical expansion undertaken by these participants to maintain their presence. In addition to business strategies, the study includes current events and key financial indicators. Readers will also have access to data on global corporate turnover for the period 2017-2022. This comprehensive report will certainly help clients stay up to date and make effective decisions in their companies.

Some of the main participants reviewed in the research report include:

Market segmentation of Live-Cell Imaging market:

Live-Cell Imaging market is divided by type and application. For the period 2021-2028, cross-segment growth provides accurate calculations and forecasts of sales by Type and Application in terms of volume and value. This analysis can help you grow your business by targeting qualified niche markets.

Live-Cell Imaging Market, By Product

Instruments Consumables Software

Live-Cell Imaging Market, By Application

Drug Discovery Developmental Biology Cell Biology Stem Cell Biology

Live-Cell Imaging Market, By End User

Academic & Research Institutes Pharmaceutical & Biotechnology Companies Academic & Research Institutes

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Live-Cell Imaging Market Report Scope

Regional Perspectives

This section of the report provides key information about the various regions and the main players operating in each region. Economic, social, environmental, technological and political factors were taken into account when assessing the growth of the region/country in question. Readers will also learn about the income of each region and country for the period 2017-2028.

The market has been segmented into several major geographic regions, including North America, Europe, Asia-Pacific, South America, the Middle East and Africa. A detailed analysis of the main countries, such as the USA, Germany, Great Britain, Italy, France, China, Japan, South Korea, Southeast Asia and India, will be considered in the regional segment. For market estimates, data will be provided for 2021 in connection with the base year, with estimates for 2022 and revenue forecast for 2028.

Middle East and Africa (GCC countries and Egypt)North America (USA, Mexico and Canada)South America (Brazil, etc.)Europe (Turkey, Germany, Russia, Great Britain, Italy, France, etc.)Asia-Pacific region (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia and Australia)

Table of Contents

Report Overview:It includes major players of the global Live-Cell Imaging Market covered in the research study, research scope, and Market segments by type, market segments by application, years considered for the research study, and objectives of the report.

Global Growth Trends:This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the global Live-Cell Imaging Market. Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the global Live-Cell Imaging Market are discussed.

Market Share by Manufacturers:Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas of key manufacturers.

Market Size by Type:This section concentrates on product type segments where production value market share, price, and production market share by product type are discussed.

Market Size by Application:Besides an overview of the global Live-Cell Imaging Market by application, it gives a study on the consumption in the global Live-Cell Imaging Market by application.

Production by Region:Here, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Consumption by Region:This section provides information on the consumption in each regional market studied in the report. The consumption is discussed on the basis of country, application, and product type.

Company Profiles:Almost all leading players of the global Live-Cell Imaging Market are profiled in this section. The analysts have provided information about their recent developments in the global Live-Cell Imaging Market, products, revenue, production, business, and company.

Market Forecast by Production:The production and production value forecasts included in this section are for the global Live-Cell Imaging Market as well as for key regional markets.

Market Forecast by Consumption:The consumption and consumption value forecasts included in this section are for the global Live-Cell Imaging Market as well as for key regional markets.

Value Chain and Sales Analysis:It deeply analyzes customers, distributors, sales channels, and value chain of the global Live-Cell Imaging Market.

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Our 250 analysts and representatives of small and medium-sized businesses have a high level of knowledge in the field of data collection and management. They use industrial methods to collect and analyze data in more than 15,000 highly efficient niches and markets. Our analysts are trained to combine modern data collection methods, excellent research methodologies, years of collective experience and expertise to conduct informative and accurate research.

We study more than 14 categories of semiconductors and electronics, chemicals, advanced materials, aerospace and defense industries, energy and consumables, healthcare, pharmaceuticals, Automotive and Transportation, Information and Communication Technologies, software and services, information security, mining, minerals and metals, construction, agricultural industry and medical equipment from in more than 100 countries.

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Live-Cell Imaging Market Size And Forecast To 2022 |GE Healthcare, Olympus Corporation, Danaher Corporation, Thermo Fisher Scientific Inc., Sartorius...

Native American and Indigenous Community Takes Shape At UConn – UConn Today – University of Connecticut

When Kat Milligan-McClellan arrived at UConn in fall 2020, she looked around at the rolling hills, the autumn leaves, and the 18th-century buildings, and immediately knew: Something was missing.

There were as many as four monuments to Nathan Hale in my town, says the assistant professor of molecular and cell biology and member of the Inupiaq people. But there was nothing about Native Americans no markers, no monuments, no acknowledgments. Nothing.

And UConn was no different.

We were struck by the level of Indigenous erasure on campus, says Sandy Grande, professor of political science, director of the new Native American and Indigenous Studies Initiative and a Quechua national. Youre hard-pressed to find anything on campus that speaks to the continued presence of Indigenous peoples.

Yet, what Grande and Milligan-McClellan did find was a committed group of students hard at work building a UConn Native American community: inviting and hosting prominent Native American speakers, creating Native American student organizations and academic communities, and supporting a mentoring program for Indigenous youth.

Student involvement has driven UConns efforts to reclaim an Indigenous presence on campus, says Grande. And together in intergenerational partnership, we now have potential to do so much more.

Native student power

In 2021, only 40 of the more than 32,000 UConn students identified as Native American or Indigenous. Grande and her colleagues know of only six Native American faculty.

It wasnt surprising, then, that in her speech at the 2022 Commencement Ceremonies, student speaker Sage Phillips 22 (CLAS), a member of the Penobscot Nation, said that when she was applying to colleges, it was clear rather quickly that UConn did not meet my list of conditions.

I did not see a strong Native and Indigenous Studies Department, nor a large community of support for Indigenous students, she said in her speech.

It was her father who counseled her to embrace the opportunity to build an Indigenous community at an institution that needed one.

Leading a small but dedicated group of Native American students, Phillips came to UConn in 2018 and founded the UConn Native American and Indigenous Students Association (NAISA), in partnership with UConns Native American Cultural Programs (NACP). Fellow student Zoe Blevins 22 (CLAS), a human rights major, founded the UConn Indigenous Nations Cultural and Educational Exchange mentorship program (UCINCEE), which pairs Indigenous youth with undergraduate students from NAISA or NACP with the goal of fostering relations between Indigenous cultures and UConn.

The students also rejuvenated the UConn chapter of the Society for Advancing Native Americans and Chicanos in Sciences (SACNAS) and hosted prominent Native American speakers on campus.

By late 2019, Native and Indigenous programming had risen to an unprecedented level.

Then in 2020, Grande, Milligan-McClellan and Assistant Professor of Anthropology Nate Acebo came to UConn as part of a planned cluster hire to bring diverse scholars and perspectives to UConn.

The professors formed the Native American and Indigenous Studies Initiative (NAISI), which serves as an academic home for the NAIS minor and associated courses and programming to strengthen the Native American and Indigenous community at UConn and beyond.

Milligan-McClellan immediately recognized the sheer amount of effort and care the student community had devoted to their cause. She and her faculty colleagues cites the students as a reason they chose UConn.

The students were the ones who really got us all together, says Milligan-McClellan. Its amazing to have such a strong student community.

Having dedicated the entirety of my undergraduate career to expanding our resources and community on campus, it felt as though we had done something right when Sandy, Kat, and the rest of the NAISI team came to UConn, Phillips says. They saw our potential and trusted us and our efforts.

With the addition of Assistant Professor of History Hana Maruyama and Assistant Professor of Educational Leadership Chen Chen, UConns first critical mass of scholars focused on the study of Indigeneity and settler colonialism was created.

A history erased

The culture and history of Native tribes in the Northeast is unique, says Grande. Northern peoples like the Mohegan, Pequot, and Nipmuc tribes have deeply overlapping histories. Prior to colonization, some tribes were once the same peoples, and those familial ties persist to this day.

Whats more, a fascination with New England colonial history has contributed to the lack of Indigenous knowledge and culture, Grande says.

New England has a history of Native erasure, says Grande, who grew up in Hartford. Children do not learn Native histories. We need to change that.

In collaboration with Glenn Mitoma, then-Director of Dodd Human Rights Impact, Phillips has worked toward this change through the research project Land Grab Connecticut. Inspired by the national Land Grab U and produced through UConns Greenhouse Studios, the project maps land data tied to Connecticut public universities, including UConn, to show how they are intertwined with colonialism, says Grande.

And thats just one step in the right direction. The NAISI faculty see UConn as uniquely positioned to become a center for Indigenous study and community in the Eastern U.S.

With colleagues at other northeastern universities such as Quinnipiac, Eastern Connecticut State University, Yale, Dartmouth, Columbia, and Brown, the faculty plan to build what theyre calling the Quinnehtukqut River Collective named for the Algonquin word giving rise to Connecticut to raise the visibility and significance of Native peoples and culture in the Northeast.

UConns central location and its history as a land-grant university makes it an ideal hub, Milligan-McClellan says.

One of the tenets of being Inupiaq, and of being Native American, is community, she explains. It was drilled in from a very early age: what you do, you do with and for your community.

IndigaPalooza!

The College of Liberal Arts and Sciences Dean Juli Wade and Associate Dean for Diversity, Equity and Inclusion Kate Capshaw have worked hard to bring Grande and her colleagues to UConn, and have been supportive of NAISI from the start, Grande says.

The College brought in five new Native studies faculty pretty much at once thats just unheard-of, says Milligan-McClellan. I thought, I want to be at the ground floor. I want to be able to shape the direction of this Indigenous community at UConn. Thats what drew me here.

With support from UConns Presidents Commitment to Community initiative, NAISI developed and presented a seminar series with panel discussions and external speakers throughout 2021-2022.

The event, colloquially known to organizers and attendees as IndigiPalooza, was co-sponsored by the Womens, Gender, and Sexuality Studies Program and their director, Associate Professor-in-Residence Sherry Zane, along with Associate Professor of English Bhakti Shringapure and her program, the Radical Books Collective.

The program culminated in a two-day conference in April 2022. which was the biggest Native American gathering in UConns history, says Grande.

More than 100 students, faculty and community members from around New England attended standing-room-only events to learn about teaching, research and advocacy for Native American issues.

IndigiPalooza featured discussions on Indigenous women in STEM, presented by Milligan-McClellan; Indigeneity as represented in multimedia, presented by Acebo; and the history of Black and Indigenous schooling and pedagogy, presented by Grande.

It also featured a workshop on integrating decolonial methods and centering Indigenous histories in teaching, and two film screenings: the Emmy-nominated End of the Line: Women of Standing Rock about the Dakota pipeline access controversy, complete with visiting members of the cast; and Beans, a story about a young Mohawk girl coming of age during the Oka Crisis, an Indigenous uprising in Canada in the 1990s.

The series was promoted and bolstered by NACP, which has long sponsored UConn programs for Indigenous Peoples Week and Native and Indigenous Heritage Month, including an annual Rising Sun Powwow in Gampel Pavilion.

The professors credit the Native American and Indigenous Student Association, the group begun by Phillips, as a major precursor to the symposium.

Native Studies at UConn

This fall, 40 Native American students were admitted to UConn, which doubles their representation on campus.

But, since so few students realize that they can study and earn a minor in Native American and Indigenous Studies, the faculty are developing a general-education class to bring the topic to students in their first years in college.

Several new undergraduate courses began last year: Milligan-McClellan taught about historically excluded and underrepresented scientists, which drew from her years of Native activism and knowledge of Black and Indigenous movements on college campuses. Grande taught a class on Native American theory and politics, and is developing a course on Indigenous Elders, aging and politics.

Outside the classroom, Grande, Milligan-McClellan, Acebo and their peers spend time mentoring Native American undergraduates and educating the broader community. There are so few Native American faculty, Grande says, that their labor is in high demand. She loves working to build Native Studies at UConn, but she looks forward to sharing the job with more Native faculty in future years.

Current NAISA president Samantha Gove 24 (CLAS), a sociology and human rights major, also hopes to see more Indigenous faculty in future years.

As a Mashantucket Pequot high school student, I never saw myself going to UConn, she admits. Ten years from now, I hope to see UConn become a university that our local Indigenous youth would be excited to attend because of their Native and Indigenous institutional support and programming, not in spite of their lack of it.

UConn as a land-grant institution has a responsibility to our community, our families, and our ancestors and that responsibility is uplifting our needs and hearing our voices, adds Phillips.

Unfolding Futures

With momentum continuing to build, the NAISI faculty are building relations between UConn and the five recognized Native tribes in Connecticut: the Mohegan, the Mashantucket Pequot, the Schaghticoke, the Golden Hill Paugussett, and the Eastern Pequot. Theyre made contact with key leaders, including Chief Mutwi Muthash (Many Hearts)Lynn Malerba 08 MPA of the Mohegan tribe, who was recently named the first Native American U.S. Secretary of the Treasury.

The NAISI faculty are working toward more physical campus space and creating a greater presence of Native and Indigenous peoples and communities on campus. The recent hire of Visiting Instructor Chris Newell of the Passamaquoddy tribe, one of the founders of the locally-based Akomawt Educational Initiative, and his expertise on approaches to Native American and Indigenous education will go a long way toward creating this presence, says Grande.

In partnership with NAISA and Native students, theyre also advocating for commemoration of Indigenous peoples on campus. This isnt just a gesture, says Milligan-McClellan its among the best ways to make Native students feel welcomed when they first set foot on campus.

It will take many years to accomplish, but their work is just starting and Milligan-McClellan says it doesnt have an end.

All of it is service, but we just think of it as living our lives, she says. Its all community-building, and thats what we do.

Some institutions want scholars who happen to be Indigenous. And other institutions make room for Indigenous scholars, adds Grande. The way we do work is different, and UConn is beginning to understand that.

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Native American and Indigenous Community Takes Shape At UConn - UConn Today - University of Connecticut

Lipids, lipids everywhere! – ASBMB Today

Lipids not only taste delicious (at least in our opinion) but are the major components of biological membranes and play essential roles in most aspects of human biology. In fact, if we look closely at the lipids and membranes of eukaryotes and prokaryotes, we see they contribute to fundamental roles in compartmentalizing cells, stress responses, metabolism, gene regulation, inflammation, and activating both cell protective and cell destructive mechanisms.

As such, the study of lipids and membranes remains a critical and emerging area for cutting-edge research one that has great potential to impact human health and the understanding and treatment of diseases.

Our symposia at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, in Seattle in March will bring together leading investigators in lipid metabolism and membrane function in replication of microorganisms and viruses, communicate novel protein structural information in lipid metabolism and transport, and promote the understanding of membrane structure and biophysics in cell physiology.

Keywords: Enzyme regulation, lipid droplets, lipid domains, membrane structure and tension, sphingolipids, infectious disease.

Who should attend: Lipid and membrane enthusiasts and anyone interested in learning more about lipid metabolism, lipidprotein interactions or membrane structure.

Theme song: Insane in the Membrane by Cypress Hill.

This session is powered by Hass avocados, rich in healthy fats.

New roles for lipids in microorganisms and virusesMichael Airola (chair), Stony Brook UniversityRobert V. Stahelin,Purdue UniversityElizabeth Johnson,Cornell UniversityEric A. Klein,Rutgers UniversityCamdenNihal AltanBonnett,National Institutes of Health

Molecular insight into lipid metabolism and transportAbdou Rachid Thiam (chair), Centre national de la recherche scientifique, Ecole Normale Suprieure de ParisMichael Airola,Stony Brook UniversityAngeline Lyon,Purdue UniversityEric Ortlund,Emory University School of MedicineSaskia Neher,University of North Carolina at Chapel Hill

Membrane structure and dynamicsRobert Stahelin (chair), Purdue UniversityAbdou Rachid Thiam,Centre national de la recherche scientifique, Ecole Normale Suprieure de ParisSarah Keller,University of WashingtonSuzanne Scarlata,Worcester Polytechnic InstituteIlya Leventhal,University of Virginia

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Lipids, lipids everywhere! - ASBMB Today

2022 Hettleman Prizes awarded to four exceptional early-career faculty – UNC Research – UNC Research

The annual Phillip and Ruth Hettleman Prizes for Artistic and Scholarly Achievement have been awarded to four promising faculty members who exemplify groundbreaking and innovative research along with future career promise.

The late Phillip Hettleman, a member of the Carolina class of 1921, and his wife Ruth established their prestigious named award in 1986 to recognize the achievements of outstanding junior faculty. The recipients of the $5,000 prize will be recognized at an upcoming Faculty Council Meeting, and will deliver a presentation on their research during University Research Week.

This years Hettleman Prize awardees are: Danielle Christmas, associate professor in the Department of English and Comparative Literature within the College of Arts and Sciences; Yuliya Pylayeva-Gupta, associate professor in the Department of Genetics within the School of Medicine; Seth A. Berkowitz, assistant professor in the Department of Medicine within the School of Medicine; and Frank Leibfarth, assistant professor in the Department of Chemistry within the College.

Danielle Christmas

Danielle Christmas studies twentieth- and twenty-first century American literature and is an author of the forthcoming book, Plantation Predators & Nazi Monsters in American Fiction and Film, and a book-in-progress titled, The Literature of Blood and Soil: White Nationalism and a New American Canon.

Danielles contributions to these literary studies are innovative and groundbreaking, says Jeanne Moskal, professor in the Department of English and Comparative Literature. Her research speaks decisively not only to specialists in her field but also to non-specialists and the general public.

In her letter of nomination for Christmas, Moskal goes on to say her comparative approach to this subject is groundbreaking. Christmas recovers and analyzes historical Black experiences and texts on their own terms, but also places these experiences and texts in a comparative frame to understand their further ramifications.

In addition to her two books, Christmas has published eight substantive peer-reviewed scholarly articles, an entry for a reference book, and an article which appeared in The New Republic.

She earned her doctorate in English literature from the University of Illinois at Chicago and her bachelors in English literature from Washington University in St. Louis.

Yuliya Pylayeva-Gupta

Yuliya Pylayeva-Guptas research is focused on pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), which is one of the deadliest and most difficult to treat of all cancers. She is a member of the UNC Lineberger Cancer Comprehensive Center (LCCC) and is internationally recognized in her field.

Pylayeva-Guptas research is aimed at reversing the immunosuppressive pancreatic cancer tumor microenvironment. She is making strides in understanding how the immune system is subverted to aid pancreatic cancer growth, metastasis, and insensitivity to immunotherapy.

In a joint nomination letter for Pylayeva-Gupta, Director of LCCC Shelton Earp says, She has done a remarkable job laying the groundwork for success in all aspects of her role as a faculty member. She has distinguished herself scientifically, devising important and timely research directions in a deadly disease which is increasing in incidence. She has built her laboratory team with talented trainees who she has mentored effectively, paying attention to their personal and professional development. She is an effective educator and a caring mentor.

Pylayeva-Gupta has published seven peer-reviewed research articles on work done in her lab at UNC-Chapel Hill, as well as two reviews and one invited editorial. She also has two research articles in press at Cell Reports Medicine and at Nature.

She earned her doctorate in cell biology and genetics at Memorial Sloan-Kettering Cancer Center in New York and her bachelors in biological chemistry and Russian language and literature at the State University of New York at Stony Brook.

Seth A. Berkowitz

Seth A. Berkowitzs research examining and addressing health-related social needs is having an impact in social medicine and is inspiring faculty and students at UNC-Chapel Hill to consider that, in many cases, the most important root causes of health are social and economic.

Throughout over 50 peer-reviewed original research publications, Berkowitz has moved from epidemiologic studies of food insecurity to designing and testing innovative interventions to address it. His work has been published in high-impact journals and has had a real impact on nutrition and health policy.

At the end of the day, medicine in America is political, and Seth is representing UNC at highly visible venues, and doing it effectively, says Janet Rubin, professor and vice chair for research in the Department of Medicine. We are very proud of his work, especially as it goes some way towards improving the health of our citizens.

Berkowitz earned his MD from the UNC School of Medicine, his bachelors in public policy analysis and psychology from UNC-Chapel Hill, and his MPH in clinical effectiveness from Harvard School of Public Health.

Frank Leibfarth

Frank Leibfarth studies polymer stereochemistry and functionalization fields that he has advanced using fundamental principles of reactivity to overturn decades-old beliefs and expand the definition of what is possible in the design of next-generation sustainable and functional materials.

Leibfarth has pioneered three innovative research programs in his group, one of which focuses on the remediation of toxic PFAS chemicals from water in North Carolina, for which he recently received a $10 million allocation in the 2021-2022 state budget.

He is listed as a coauthor on over 42 peer-reviewed manuscripts, and regularly collaborates with organic chemists, computer scientists, environmental engineers, materials scientists, and mechanical engineers.

Quite simply, Professor Leibfarth is one of the most creative, fearless, and talented young scientists of his generation, says Wei You, professor and chair of the Department of Chemistry. I strongly contend that he is and will continue to be one of the most important chemists of his generation.

Leibfarth earned his doctorate in chemistry and biochemistry at the University of California Santa Barbara and his bachelors in chemistry and physics from the University of South Dakota.

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2022 Hettleman Prizes awarded to four exceptional early-career faculty - UNC Research - UNC Research

RAPT Therapeutics Strengthens Leadership Team with Two New Key Hires – BioSpace

SOUTH SAN FRANCISCO, Calif., Sept. 28, 2022 (GLOBE NEWSWIRE) -- RAPT Therapeutics, Inc.(Nasdaq: RAPT), a clinical-stage, immunology-based biopharmaceutical company focused on discovering, developing and commercializing oral small molecule therapies for patients with significant unmet needs in inflammatory diseases and oncology, today announced the appointment of Jennifer Nicholson as Senior Vice President of Regulatory Affairs and Quality Assurance and Adnan Rahman as Vice President of Commercial.

It is a pleasure to welcome both Jennifer and Adnan to the RAPT leadership team at this exciting time of growth for the Company, said Brian Wong, M.D., Ph.D., President and Chief Executive Officer of RAPT Therapeutics. The combination of their regulatory, commercial and marketing expertise is invaluable as we advance our RPT193 program into late stage trials in atopic dermatitis and asthma and continue development of FLX475 program in multiple cancer indications.

Jennifer Nicholson Jennifer brings over 20 years of biotechnology and pharmaceutical industry regulatory expertise, with significant experience across all stages of development in oncology including hematologic malignancies and solid tumors. Most recently, she served as Vice President of Regulatory Affairs at Kronos Bio. Prior to Kronos Bio, she was Head of Global Regulatory Science at Acerta Pharma, a member of the AstraZeneca Group. Jennifer was the Global Regulatory Lead for the Calquence (acalabrutinib) US NDA, which was granted accelerated approval in 2017, as well as for subsequent global filings. Prior to joining Acerta, Jennifer was Senior Director of Regulatory Affairs at Bavarian Nordic, where she focused on immuno-oncology and vaccine products. Earlier in her career, Jennifer worked as the Global Regulatory Lead on various hematology and oncology products at Jazz Pharmaceuticals, Onyx Pharmaceuticals and Genentech. Jennifer holds a B.S. in Biochemistry and Cell Biology from the University of California, San Diego and an M.H.A. from the Gillings School of Global Public Health at the University of North Carolina at Chapel Hill.

Adnan RahmanAdnan brings over 20 years of biopharmaceutical commercial and marketing expertise. Most recently, he served as Global Commercial Lead of Dermatology at Arena Pharmaceuticals, acquired by Pfizer., where he led global commercial strategy for its principal asset, Etrasimod, in atopic dermatitis and alopecia areata. Prior to Arena Pharmaceuticals, he was U.S. Commercial Director of XGEVA (denosumab) at Amgen and held various senior marketing positions in oncology, bone health and inflammation business units. Earlier in his career, Adnan held various marketing positions at Pharmacia and Procter & Gamble. Adnan holds an M.B.A. from Rutgers University and an M.A and B.A. in Electrical Engineering from University of Cambridge.

About RAPT Therapeutics, Inc.RAPT Therapeutics is a clinical stage immunology-based biopharmaceutical company focused on discovering, developing and commercializing oral small molecule therapies for patients with significant unmet needs in inflammatory diseases and oncology. Utilizing its proprietary discovery and development engine, the Company is developing highly selective small molecules designed to modulate the critical immune drivers underlying these diseases. RAPT has discovered and advanced two unique drug candidates, RPT193 and FLX475, each targeting C-C motif chemokine receptor 4 (CCR4), for the treatment of inflammation and cancer, respectively. The Company is also pursuing a range of targets that are in the discovery stage of development.

RAPT Media Contact:Aljanae Reynoldsareynolds@wheelhouselsa.com

RAPT Investor Contact:Sylvia Wheelerswheeler@wheelhouselsa.com

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RAPT Therapeutics Strengthens Leadership Team with Two New Key Hires - BioSpace

PostDoctoral Research Assistant in Single Cell Mass Spectrometry job with UNIVERSITY OF SURREY | 310566 – Times Higher Education

Chemistry

Location: GuildfordSalary:34,308 to 42,155 per annumFixed TermPost Type:Full TimeClosing Date: 23.59 hours BST on Sunday 23 October 2022Reference: 067422

The University of Surrey is opening a unique national facility for spatially resolved live single cell omics (SEISMIC). This centre will welcome industry and academic users from across the UK. SEISMIC will use the new cutting-edge Yokogawa SS2000 instrumentation to extract single cells, and even subcellular compartments from cells cultured whilst under microscope observation. Extracted cell contents can then be analysed using mass spectrometry omics at Surrey, and within collaborators. The methodology is also compatible with genome and RNA analysis. The SEISMIC award includes funds for researchers to travel to Surrey to conduct experiments. SEISMIC will enable scientific discoveries in a completely new way in distinct areas including drug discovery, infection, stem cell biology, immunity and ageing.

We are looking for motivated, enthusiastic individuals with excellent interpersonal, academic and technical skills to join our growing team and help us to set up and run SEISMIC. The postholder will help to drive forward the analytical measurement capability to enhance the sensitivity and reproducibility of single cell measurements of proteins, metabolites and lipids. The successful applicants will also work with a variety of users using the research base and will have opportunity to undertake development work too. There are therefore excellent opportunities for publication and career development for team-oriented scientists. You will need at least PhD degree in chemistry, biochemistry or related discipline. Experience in biological mass spectrometry would be preferred.

For enquiries and further information please contact Professor Melanie Baileym.bailey@surrey.ac.uk, Tony Whettona.whetton@surrey.ac.ukor Paul Townsendp.townsend@surrey.ac.uk

or more informationand to apply online, please download the further details and click on the 'apply online' button above.

In return we offer a generous pension, relocation assistance where appropriate, flexible working options including job share and blended home/campus working locations (dependent on work duties), access to world-class leisure facilities on campus, a range of travel schemes and supportive family friendly benefits including an excellent on-site nursery.

Click here to find out more about the benefits we offer to support you.

The University of Surrey is committed to providing an inclusive environment that offers equal opportunities for all. We place great value on diversity and are seeking to increase the diversity within our community. Therefore we particularly encourage applications from under-represented groups, such as people from Black, Asian and minority ethnic groups and people with disabilities.

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PostDoctoral Research Assistant in Single Cell Mass Spectrometry job with UNIVERSITY OF SURREY | 310566 - Times Higher Education

Research Fellow, Department of Anatomy and Physiology job with UNIVERSITY OF MELBOURNE | 310587 – Times Higher Education

Location:ParkvilleRole type:Full time; Fixed-termfor 12 monthsFaculty: Medicine, Dentistry and Health SciencesDepartment/School:Department of Anatomy and PhysiologySalary:Level A $77,171 $104,717p.a. (pro rata for part-time) plus 17% super

The University of Melbourne would like to acknowledge and pay respect to the Traditional Owners of the lands upon which our campuses are situated, the Wurundjeri and Boon Wurrung Peoples, the Yorta Yorta Nation, the Dja Dja Wurrung People. We acknowledge that the land on which we meet and learn was the place of age-old ceremonies, of celebration, initiation and renewal, and that the local Aboriginal Peoples have had and continue to have a unique role in the life of these lands.

About the Department of Anatomy and Physiology

The Department of Anatomy and Physiology has only recently come into fruition and is an amalgamation between the Departments of Anatomy and Neuroscience and Physiology. Both Departments have long and illustrious history and have come together to produce a Department with a remarkable breadth and depth in research expertise that underpin our key research themes of neuroscience, metabolism and cardiovascular sciences, muscle biology, and cell biology.

The goal of the combined department is to remain at the forefront of scientific research aimed at understanding the structure and function of the human body in health and disease, employing novel and imaginative research methods.

About the Role

The Research Fellow will work within the Wells Laboratory on NHMRC funded research. The role will conduct supervised research using pluripotent stem cells to model macrophage biology. The role will also require the provision of support for research projects and programs within the laboratory, including administration and maintenance and use of information systems.

Responsibilities include:

About You

You will be an experienced research fellow with experience and expertise in pluripotent stem cell culture or human macrophage biology. Your excellent verbal and written communication skills allow you to demonstrate effective research collaboration and engagement. Your strong organisational skills allow you to maintain accurate and detailed laboratory records, and manage competing priorities.

You will also have:

About the University

The University of Melbourne is consistently ranked amongst the leading universities in the world. We are proud of our people, our commitment to research and teaching excellence, and our global engagement.

Benefits of Working with Us

In addition to having the opportunity to grow and be challenged, and to be part of a vibrant campus life, our people enjoy a range of rewarding benefits:

To find out more, visithttps://about.unimelb.edu.au/careers/staff-benefits.

Be Yourself

We value the unique backgrounds, experiences and contributions that each person brings to our community and encourage and celebrate diversity. First Nations people, those identifying as LGBTQIA+, females, people of all ages, with disabilities and culturally and linguistically diverse people are encouraged to apply. Our aim is to create a workforce that reflects the community in which we live.

Join Us!

If you feel this role is right for you, please submit your application including a brief cover letter, your resume and your responses against the selection criteria^ (found in the Position Description) for the role.

^For information to help you with compiling short statements to answer the selection criteria and competencies, please go tohttp://about.unimelb.edu.au/careers/selection-criteria

We are dedicated to ensuring barrier free and inclusive practices to recruit the most talented candidates. If you require any reasonable adjustments with the recruitment process, please contact us athr-talent@unimelb.edu.au.

Please note: To be considered for this role you must havecurrent valid work rights for Australia

osition Description:0057175 - PD.pdf

Applications close:27 Oct2022 11:55 PMAUS Eastern Standard Time

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Research Fellow, Department of Anatomy and Physiology job with UNIVERSITY OF MELBOURNE | 310587 - Times Higher Education

LBUSD’s Teacher of the Year is a homegrown educator who explains the world with literature Long Beach Post News – Long Beach Post

For Lee Underwood, that moment arrived when he was a high school student at nearby St. John Bosco. One class in particular changed his outlook on the world and inspired the next few decades of his life.

As of last week, that moment has officially come full circle for Underwood, who was recognized as the Long Beach Unified School Districts Teacher of the Year.

An Advanced Placement English Literature and Composition teacher at Millikan High School, Underwood credits his former AP Literature teacher and soccer coach, Jim Cross, for helping spark his love of English and for helping to inspire his career path.

He had this passion for books and teaching poetry that I had just never seen before, recalled Underwood. Me and my angsty self at that time, really connected with the way that he saw poetry as a living thing, as a salve for the troubled soul, or even as a path to self-transformation. So I would read these poets and these books and he would talk about them in ways that really allowed me to make sense of myself.

As the son of a teacher, Underwood spent countless hours in his moms classroom growing up. During his college years as a student at Cal State Long Beach, Underwood again drew inspiration from an English professor, Joe Potts, who helped shape his view on what it means to be a teacher.

He was the one that really got me fired up about pedagogy, Underwood explained. The idea that teachers are artists and their content is their palette; the books they teach, the way that they teach, all those things are very creative processes that the teacher can bring into the classroom. And I really liked that idea. It was at that moment that I decided to go full force into English education in college and pursue my teaching credential.

Underwood started his teaching career at Millikan back in 2006, as a 23-year-old fresh out of his student teaching program. Hes now in his 17th year on campus and has been inspiring his students the same way Mr. Cross did for him.

Underwood said he enjoys cultivating a classroom environment where students can discuss major issues affecting their everyday lives. He acknowledged that those discussions have evolved in the past few years due to the global pandemic and social unrest across the globe. Through literature, hes helped students gain different perspectives on some of the big, complex issues theyre seeing in the world.

The fantastic thing about teaching a humanities class is that its exactly the right place for a student to try to make sense of things that sometimes dont make sense to them, he explained. Ive seen students become much more serious about loss and grief, because its very possible that these students have seen much more of that over the last couple of years than they ever have before. Im in a really unique position to have these students ask these questions of themselves and to guide them through their own thinking using these texts.

One of his former students, Astrid Quirarte, wrote a letter of support for Underwood winning Teacher of the Year while she was attending UC Berkeley to study molecular and cell biology. Her words spoke to Underwoods dedication to his students, and also his willingness to incorporate contemporary issues into his curriculum.

In all my years in school, I have never met a teacher as approachable and caring as Mr. Underwood, Quirarte wrote. Of all Mr. Underwoods attributes, I consider his greatest to be the genuine care he has for all of his students. He would spend extra time after class reading and editing our college application essays, something I greatly benefitted from as a first-generation college student As a Latinx student, I had encountered multiple English classes that incorporated literature that was not representative of the student body and the real-world challenges students faced. Mr. Underwoods integration of contemporary issues regarding discussions of class, race, sex and gender identity was the first time I ever felt seen in the classroom setting.

Underwood described the Teacher of the Year award as an immense honor but alsosomewhat ironicallyhe struggled to put his emotions into words.

It just melts my heart, I dont know how else to explain it, Underwood said. Nothing, no amount of money can take the place of the words that Astrid wrote about me. It makes me realize that this is the right place to be.

Im exactly in the right place.

Local history: No soapProcter & Gambles Long Beach plant closed in 1988

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LBUSD's Teacher of the Year is a homegrown educator who explains the world with literature Long Beach Post News - Long Beach Post

Quran and the Modern Science – Brighter Kashmir

Sequential narrative like the book of Genesis.Quran is about as long as the New Testament .In most editions it is about 600 pages in length

The first thing to understand about the Quran is its form. The arabic word Quran literally both 'recitation' and 'reading' . similarly the Quran was both recited orally and written down in book form .The true power of Quran remains in the oral recitation, as it is want to be read aloud and melodiously,

But still the verses were written down on available materials as an aid to memorizing and guarding it, and these were collected and ordered in book form both privately and, at a later stage, institutionally. The Quran was not meant to tell chronological story, and thus the Quran should not be viewed as Sequential narrative like the book of Genesis. Quran is about as long as the New Testament .In most editions it is about 600 pages in length.So, the main theme of writing this article is to spread the message to all people that there is nothing in this world that is not mentioned in our Quran and today we are going to look at one of the miracles or we can say the scientific fact that is mentioned in our quran.Human body is known as the crown of all the creations [Ashraf-ul-Makhlukat] because of its complexity and advancement, lets start by the origin of human body called 'Embryology 'in science. A few years ago a group of Arabs collected all the information about embryology from the Quran and was then translated into English by Dr.Keith Moore, who was the professor of embryology at university of Toronto in Canada, he said that the most of the information concerning embryology mentioned in Quran is perfect ,it is obvious that he could not say whether the statements were true or false, since he himself was not aware of the information mentioned in the Quran. There was no mention of this information in modern writings and studies on embryology. One such verse is: Proclaim ![or read!] in the nameof the lord and cherisher, who created man,out of a [mere]clot of the congealed blood.'{Al Quran 96:1-2}The word ALAQ besides meaning a congealed clot of blood also means something that clings, a leech-like substance . Dr.Keith Moore had no knowledge whether an embryo in the initial stages appear like a leech. To check this out he studied the initial stages of the embryo under a very powerful microscope in his laboratory and compared what he observed with a diagram of a leech and he was astonished at the striking resemblance between the two!.In the same manner, he acquired more information on embryology that was hitherto not known to him, from the Quran Dr.Keith answered about eighty questions dealing with embryological data mentioned in the Quran and Hadith. Nothing that the information contained in the Quran was full agreement with the latest discoveries in the field ofembryology Dr. said 'If i was asked these questions thirty years ago, I would not have been able to answer half of them for lack of information.Dr. Moore had earlier authored the book, 'The Developing Human' After acquiring new knowledge from the Quran he wrote in 1982,the third edition of the same book and was then recipient of an award for the best medical book written by a single author. This book has been translated into several major languages of the world and is used as a textbook of embryology in the first year of medical studies.In 1981, during the Seventh Medical Conference in Dammam, Saudi Arabia,Dr. said,It has been a great pleasure for me to help clarify statements in the Quran about human development. It is clear to me that these statements must have come to Muhammad[PBUH] from almighty ALLAH, because almost all of this knowledge was not discovered until many centuries later. This proves to me that Mohammad[PBUH]must have been a messenger of ALLAH. So,these Hadiths, sayings of Mohammad[PBUH] could not have been obtained on the basis of the scientific knowledge which was not available at that time. It follows that not only is there no conflict between genetics and religion[ISLAM] but in fact Islam may guide science by adding revelation to some of the traditional scientific approaches. Thus the Quranic description matches with the discoveries in modern embryology.

Email:-----------------faizanm1232@gmail.com

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Quran and the Modern Science - Brighter Kashmir