Psychedelics May Help People Reinvent Themselves – Neuroscience News

Summary: In addition to helping treat mental health disorders, psychedelic treatments can help people overcome addictions. A new study reports psychedelics can help smokers quit nicotine and remain smoke-free for at least five years.

Source: University of Cincinnati

Researchers from the University of Cincinnati examined the post-treatment journals kept by participants in a 2014 smoking cessation study that found psychedelics were effective in helping some people quit smoking for years.

In a new paper published in theKennedy Institute of Ethics Journal, researchers analyzed the participants own words and found that psychedelics combined with talk therapy often helped longtime smokers see themselves as nonsmokers. This new core identity might help explain why 80% of participants were able to stopsmokingfor six months and 60% remained smoking-free after five years.

The 2014 study by researchers at Johns Hopkins University found that participants who wanted to quit smoking and used psilocybin, the active hallucinogenic ingredient inpsychedelicmushrooms, combined withcognitive behavioral therapywere far more likely to succeed than those who try other traditional quit-smoking methods.

Lead author and University of Cincinnati postdoctoral researcher Nee Devenot said the results demonstrate the potential psychedelics have to reshape self-perceptions to help people break free of old habits or addictions in the face of lifes daily triggers and temptations.

We saw again and again that people had this feeling that they were done with smoking and that they were a nonsmoker now, Devenot said.

She studies the science, history and culture of psychedelics in UCs Institute for Research in Sensing.

Devenot said this new sense of self might help arm people against temptation or old triggers.

If you want to give up meat but you smell a delicious steak, it might be hard to resist, she said. But if you identify as a vegetarian and your sense of who you are is someone who does not eat meat, that identity helps encourage a different choice.

During the smoking cessation study, therapists gave participants guided imagery exercises in which they were asked to envision smoking as a behavior external to their core identity. The participants documented their experience in writing.

One guided imagery exercise from the study framed nicotine addiction as an external force, manipulating behavior for its own ends like the zombie-creating fungus in HBOs popular series The Last of Us.

Like the Cordyceps fungi that functionally transforms insects into zombified marionettes to serve the fungis own reproductive purposes, smoking behavior is characterized as a form of parasitic manipulation, the study found.

Albert Garcia-Romeu, an assistant professor of psychiatry andbehavioral sciencesat Johns Hopkins University, said psilocybin could serve as a catalyst to help motivate and inspire people to make a change with the help of cognitive behavioral therapy.

Cognitive behavioral therapy asks us to tune into the thoughts and feelings that we experience in our day-to-day lives and how those relate to our behaviors, Garcia-Romeu said. In turn, people often tend to build a narrative or sense of self around those cognitions and behaviors.

This sets the stage for actually having the psilocybin experience, which can both provide novel insights and perspectives as well as serve as a marker of that identity shift like a rite of passage, signifying the change for instance from smoker to nonsmoker.

Devenot said the experiments sample size was relatively small at just 15 participants. But the results are encouraging.

I feel that I am somehow fundamentally different to yesterday, one participant wrote. I guess I feel like some sort of metamorphosis has taken place!

Some participants said the treatment with psilocybin made quitting feel easy compared to past experiences. Another said the cravings for nicotine used to be unbearable. But during the dosing session, the participant was unable even to imagine craving a cigarette.

The concept seems firmly cemented into my reality even today, that cravings are not something that are real, one said.

How do psychedelics help with this transformation?

Devenot says people often get stuck in the same ruts of behavior, responding the same way to stressors or other triggers. She likens it to a downhill skier who uses the same grooved path down the mountain that they have used a thousand other times.

Its not that simple, but its a metaphor for how we talk about psychedelics, Devenot said.

Psychedelics have been compared to skiing in fresh snow, she said. The entrenched grooves of bad habits might not have as much pull on our skis, so we can lay down other paths.

Were looking for ways to help people shift behaviors and overcome the inertia of their habits that are more in line with their goals and aspirations, Devenot said. Thats why psychedelics are of wider interest to researchers.

Author: Michael MillerSource: University of CincinnatiContact: Michael Miller University of CincinnatiImage: The image is in the public domain

Original Research: Closed access.Psychedelic Identity Shift: A Critical Approach to Set And Setting by Nee Devenot et al. Kennedy Institute of Ethics Journal

Abstract

Psychedelic Identity Shift: A Critical Approach to Set And Setting

While the literature on psychedelic medicine emphasizes the importance of set and setting alongside the quality of subjective drug effects for therapeutic efficacy, few scholars have explored the therapeutic frameworks that are used alongside psychedelics in the lab or in the clinic.

Based on a narrative analysis of the treatment manual and post-session experience reports from a pilot study of psilocybin-assisted treatment for tobacco smoking cessation, this article examines how therapeutic frameworks interact with the psychedelic substance in ways that can rapidly reshape participants identity and sense of self.

We identified multiple domains relating to identity shift that appear to serve as smoking cessation mechanisms during psilocybin sessions, each of which had an identifiable presence in the manualized treatment.

As psychedelic medicine becomes mainstream, consensual and evidence-based approaches to psychedelic-assisted identity shift that respect patient autonomy and encourage empowerment should become areas of focus in the emergent field of psychedelic bioethics.

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Could ChatGPT Replace Doctors in Infection Consulting Scenarios? – Neuroscience News

Summary: While there is clear potential to use ChatGPT in a clinical setting, researchers say the AI algorithm may not yet be a reliable way of replacing the family doctor, especially when it comes to making effective decisions about prescribing antibiotics for infections.

Source: University of Liverpool

Researchers from the University of Liverpool have tested whether the AI-powered chatbot ChatGPT could be used to make decisions about prescribing patients with antibiotics.

In a letter published inThe Lancet Infectious Diseases, academics from the Institute of Systems, Molecular and Integrative Biology show that, whileartificial intelligencecant yet replace thefamily doctor, there is clear potential for technology to play a role inclinical practice.

The researchers presented ChatGPT with eight hypothetical infection scenarios which people would commonly consult their doctor about (such as a chest infection). They then assessed the advice delivered by the technology for its appropriateness, consistency and its impact onpatient safety.

Theassessmentfound that ChatGPT understood the scenarios and provided coherent answers, including disclaimers, and signposting patients to sources of advice. It also appeared to understand the need to only prescribeantibioticswhen there was evidence of bacterial infection.

However, ChatGPT provided unsafe advice in complex scenarios and where important information was not explicitly provided.

Interestingly, the AI tended to focus on the type of antibiotic prescribed in each scenario rather than other factors, reflecting the assumptions often initially made by doctors during consultation.

Following the experiment, the researchers have now developed a checklist for standards that AI should meet in order to be considered for use in clinical practice in the future.

Co-author of the letter, Dr. Alex Howard said, It was fascinating to see the potential of artificial intelligence in health care demonstrated through this experiment testing ChatGPTs ability to give antibiotic treatment advice.

With the rise of antibiotic resistance posing a significant threat to global health, the ability of AI to provide accurate and safe treatment advice could revolutionize the way we approach patient care. We look forward to further exploration of this technology and its implications for the future of health care.

Author: Press OfficeSource: University of LiverpoolContact: Press Office University of LiverpoolImage: The image is in the public domain

Original Research: Open access.ChatGPT and antimicrobial advice: the end of the consulting infection doctor? by Alex Howard et al. Lancet Infectious Diseases

Abstract

ChatGPT and antimicrobial advice: the end of the consulting infection doctor?

Generative artificial intelligence (AI) models have proliferated in the past 2 years. ChatGPTa large language model (LLM) developed by OpenAI (San Francisco, CA)mimics natural language and solves cognitive problems by reinforcing learning from online resources using human feedback.

Despite access to limited medical data, ChatGPT has medical licensing examination performance as an undergraduate third-year medical student, and has, therefore, stimulated urgent discussions within medicine.

Stokel-Walker and van Noorden discuss the implications of generative AI for science and describe how ChatGPT could answer some open-ended medical queries almost as well as the average human physician could, although it still had shortcomings and unreliabilities.

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Study Finds Link Between Chronic Pain and Dementia – Neuroscience News

Summary: People with chronic pain in multiple parts of the body have a higher risk of developing dementia and accelerated cognitive decline.

Source: Chinese Academy of Science

A research team led by Dr. TU Yiheng from the Institute of Psychology of the Chinese Academy of Sciences has found that people with chronic pain in multiple parts of the body had a higher risk of dementia and experienced broader and faster cognitive decline, including memory, executive function, learning, and attention.

The study was published online inPNASon Feb. 20.

Multisite chronic pain, where pain is experienced in multiple anatomical locations, affects almost half of chronic pain patients and has been found to place a greater burden on patients overall health. However, it has not been clear whether people with multisite chronic pain suffered from aggravated neurocognitive abnormalities.

In this study, after analyzing the records of 354,943 people in the UK Biobank cohort, the researchers found that the risk of neurocognitive abnormality increased with each additional pain site and was mediated by atrophy in the hippocampus, the part of the brain responsible for memory.

Since hippocampal volume decreases with age, the researchers equated the magnitude of the effect of hippocampal atrophy in patients with multisite chronic pain to the effect of aging in healthy people with an average age of 60.

Multisite chronic pain may lead to up to eight years of accelerated hippocampal aging, an effect that may underlie a series of cognitive burdens, said Dr. TU, corresponding author of the study.

The study provides a quantitative understanding of the impact of chronic pain on cognitive function and the risk of dementia, laying an important foundation for future research into the relationship between chronic pain and cognitive impairment.

It also highlights the excessive burden of multisite chronic pain on patients cognition and the brain, and the need to address the overlapping nature of pain conditions in both basic research and clinical studies.

Funding: This study was supported by the STI2030-Major Projects Program, the National Natural Science Foundation of China, and the Scientific Foundation of the Institute of Psychology of CAS, among other sources.

Author: TU YihengSource: Chinese Academy of ScienceContact: TU Yiheng Chinese Academy of ScienceImage: The image is in the public domain

Original Research: Closed access.Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain by TU Yiheng et al. PNAS

Abstract

Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain

Numerous studies have investigated the impacts of common types of chronic pain (CP) on patients cognitive function and observed that CP was associated with later dementia. More recently, there is a growing recognition that CP conditions frequently coexist at multiple body sites and may bring more burdens on patients overall health.

However, whether and how multisite CP (MCP) contributes to an increased risk of dementia, compared to single-site CP (SCP) and pain-free (PF), is largely unclear.

In the current study, utilizing the UK Biobank cohort, we first investigated dementia risk in individuals (n = 354,943) with different numbers of coexisting CP sites using Cox proportional hazards regression models. We then applied generalized additive models to investigate whether MCP leads to excessive deterioration of participants (n = 19,116) cognition and brain structure.

We found that individuals with MCP were associated with significantly higher dementia risk, broader and faster cognitive impairment, and greater hippocampal atrophy than both PF individuals and those with SCP.

Moreover, the detrimental effects of MCP on dementia risk and hippocampal volume aggravated along with the number of coexisting CP sites. Mediation analyses further revealed that the decline of fluid intelligence in MCP individuals was partially mediated by hippocampal atrophy.

Our results suggested that cognitive decline and hippocampal atrophy interact biologically and may underlie the increased risk of dementia associated with MCP.

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Study Finds Link Between Chronic Pain and Dementia - Neuroscience News

Medtronic’s Q3 Exceeds Expectations On Strong Cardiovascular … – Yahoo Finance

Medtronic Plc's(NYSE: MDT)Q3 FY23 sales of $7.73 billionflat Y/Y on a reported basis and increased 4.1% organically, beating the consensus of $7.53 billion.

The organic comparison excludes a $379 million negative impact from foreign currency translation and a $26 million contribution from its fiscal first quarter acquisition of Intersect ENT, which is reported in the Specialty Therapies division in the Neuroscience Portfolio.

The adjusted EPS of $1.30 exceeded the consensus of $1.27, and decreased by 4%.

Organic revenue results reflect strong performances in the Cardiovascular and Neuroscience portfolios, Diabetes markets outside the U.S., and improved product availability across certain businesses, partially offset by unfavorable impacts from ventilator sales.

Medtronic's heart device unit sales increased 1% Y/Y (+7% organic) to $2.77 billion.

Spine & neurosurgery product segment sales increased 5% Y/Y (+7%) to $2.25 billion.

Diabetes revenue of $570 million decreased by 2% (+3%).

The Medical Surgical Portfolio sales decreased 7% (-2% organic) to $2.14 billion.

Guidance:The company expects Q4 FY23 organic revenue growth of 4.5% to 5.0%. Currency headwinds could affect Q4 sales by approximately $165-$215 million.

Medtronic tightens FY23 EPS outlook to $5.28 - $5.30 ($5.25 - $5.30 Prior), compared to the consensus of $5.44.

Price Action:MDT shares are up 2.49% at $86.91 during the premarket session on the last check Tuesday.

Don't miss real-time alerts on your stocks - join Benzinga Pro for free! Try the tool that will help you invest smarter, faster, and better.

This article Medtronic's Q3 Exceeds Expectations On Strong Cardiovascular And Neuroscience Performance, Tightens FY23 Outlook originally appeared on Benzinga.com

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Medtronic's Q3 Exceeds Expectations On Strong Cardiovascular ... - Yahoo Finance

Any Regular Physical Activity at Any Age Linked to Better Brain … – Neuroscience News

Summary: At any age, regular exercise or physical activity helps to maintain brain function during old age. However, maintaining a frequent workout schedule throughout life was linked to better mental acuity, memory, and cognition later in life.

Source: BMJ

Any regular leisure time physical activity at any age is linked to better brain function in later life, but maintaining an exercise routine throughout adulthood seems to be best for preserving mental acuity and memory, suggests a long term study published online in theJournal of Neurology Neurosurgery & Psychiatry.

Even though factoring in childhood cognitive ability, household income, and education weakened the observed associations, the findings remained statistically significant.

Physical activity is modestly associated with a lower risks of dementia, cognitive decline, and loss of later life mental acuity. But its not known whether the timing, frequency, or maintenance of leisure time physical activity across the life course might be key to later life cognitive abilities.

The researchers were particularly keen to know if physical activity might be most beneficial in specific sensitive periods across the life course, or across multiple time periods.

To try and find out, they looked at the strength of associations between a range of cognitive tests at age 69 and reported leisure time physical activity at the ages of 36, 43, 53, 60-64, and 69 in 1417 people (53% women) taking part in the 1946 British birth cohort study.

Physical activity levels were categorised as: inactive; moderately active (14 times/month); most active (5 or more times/month), and summed across all 5 assessments to create a total score ranging from 0 (inactive at all ages) to 5 (active at all ages).

Some 11% of participants were physically inactive at all 5 time points; 17% were active at one; 20% were active at two and three; 17% were active at four and 15% at all five.

Cognitive performance at age 69 was assessed using the validated ACE-111, which tests attention and orientation, verbal fluency, memory, language, and visuospatial function, plus by tests of verbal memory (word learning test) and processing speed (visual search speed).

Factors associated with a heightened risk of cognitive declinecardiovascular and mental health, and carriage of the APOE-4 genewere also assessed to see if these modified any observed associations.

Analysis of the results showed that being physically active at all 5 time points was associated with higher cognitive performance, verbal memory, and processing speed at the age of 69.

The effect sizes were similar across all adult ages, and for those who were moderately and most physically active, suggesting that being physically active at any time in adulthood, even if participating as little as once per month, is linked with higher cognition, write the researchers.

But the strongest association was observed for sustained cumulative physical activity and later life cognition, and for those who were most physically active at all ages.

The positive association between cumulative physical activity and later life cognitive performance was partly explained by childhood cognition, socioeconomic position, and education.

But the effect remained significant when these were factored in, and the associations werent explained by differences in later life cardiovascular or mental health.

Together, these results suggest that the initiation and maintenance of physical activity across adulthood may be more important than the timing.or the frequency of physical activity at a specific period, say the researchers.

This is an observational study, and as such, cant establish cause, and the researchers acknowledge various limitations to their findings.

The study included only White participants and had a disproportionately high attrition rate among those who were socially disadvantaged. No information was available on exercise intensity, duration, or adherence either.

But they nevertheless conclude: Our findings support guidelines to recommend participation in any physical activity across adulthood and provide evidence that encouraging inactive adults to be more active at any time, and encouraging already active adults to maintain activity, could confer benefits on later life cognition.

Author: Press OfficeSource: BMJContact: Press Office BMJImage: The image is in the public domain

Original Research: Open access.Timing of physical activity across adulthood on later life cognition: 30 years follow-up in the 1946 British birth cohort by Sarah-Naomi Jameset al. Journal of Neurology Neurosurgery & Psychiatry

Abstract

Timing of physical activity across adulthood on later life cognition: 30 years follow-up in the 1946 British birth cohort

Background

To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function.

Methods

Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation in leisure time physical activity was reported five times between ages 36 and 69, categorised into: not active (no participation in physical activity/month); moderately active (participated 14 times/month); most active (participated 5 or more times/month). Cognition at age 69 was assessed by tests of cognitive state (Addenbrookes Cognitive Examination-III), verbal memory (word learning test) and processing speed (visual search speed).

Results

Being physically active, at all assessments in adulthood, was associated with higher cognition at age 69. For cognitive state and verbal memory, the effect sizes were similar across all adult ages, and between those who were moderately and most physically active. The strongest association was between sustained cumulative physical activity and later-life cognitive state, in a dose-response manner. Adjusting for childhood cognition, childhood socioeconomic position and education largely attenuated these associations but results mainly remained significant at the 5% level.

Conclusions

Being physically active at any time in adulthood, and to any extent, is linked with higher later-life cognitive state, but lifelong maintenance of physical activity was most optimal. These relationships were partly explained by childhood cognition and education, but independent of cardiovascular and mental health and APOE-E4, suggestive of the importance of education on the lifelong impacts of physical activity.

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Any Regular Physical Activity at Any Age Linked to Better Brain ... - Neuroscience News

Temperature Changes in the Brain Found to Affect Neuronal Activity – Neuroscience News

Summary: Small temperature increases while stimulating the brain can alter brain activity, sometimes with negative consequences.

Source: Yale

Last summer, devastating wildfires raged across frozen regions in Siberia, Alaska, and Canada. They were caused in part by rising global temperatures, which accelerated the ability of bacteria in the soil to metabolize plant and animal matter.

These environmental phenomena demonstrated a basic principle of physicstemperature is one of the main components of a chemical reaction and even seemingly small changes can result in catastrophic impacts. Heat a Siberian peat bog faster than it can release carbon into the atmosphere, and you get a wildfire on your handseven in subzero temperatures.

Researchers now know that the physics behind this environmental phenomenon apply also to brain activity. In a paper published in theJournal of Neural Engineering, researchers found that small increases in temperature while stimulating the brain can profoundly alter brain activity, sometimes with negative consequences.

Steven Schiff, MD, vice chair for global health in Neurosurgery at Yale School of Medicine, specializes in the intersection between engineering and neurosurgery, which gives him the background to apply principles of physics to the biological processes of the brain.

Since activity in wires produce heat, all electric and magnetic stimulation of the brain deposits thermal energy in the brain. Schiff and his co-authors theorized that electric stimulating brain devices such as Deep Brain Stimulation, used in epilepsy and Parkinsons disease patients, must lead to temperature changes in the brain.

Temperature changes in the brain also affect the firing of neurons. Lining the membranes of nerve cells are molecular pumps that electrically charge up the cells with energy that they release during brain activity. The researchers were able to prove that if cells are heated faster than the charges can adjust, then they may either produce more neuronal activity or less than usual.

Even small changes in temperature due to electrical stimulation of the brain less than 1C, could lead to substantial changes in neuronal activity. As neurons warm they can go silent. Let them cool back to their normal temperature and they can get very excitable.

Seeing these dramatic effects onbrain activityfrom small changes in temperature means that we now need to take such small temperature changes into account, says Schiff, lead author of the study.

[Physicist James] Joule, long ago, taught us that there is no way around this problem. If you pass electrical current through small conductive wires to generate electrical or magnetic fields to stimulate the brain, you generate heat both in the wires and in the conductive brain.

This paradigm shifting paper was presented in December 2022, at the American Epilepsy Society meeting in Washington DC where it was received with great interest.

How these temperature changes affect the patient and how they could be harnessed to improve outcomes remains to be seen. Inclinical settings, surgeons have observed previously that a common side effect to implanting nervous system stimulators is that the activity of stimulated brain often decreases with either electrical or magnetic stimulation.

The paper points to a strong plausible cause for this phenomenon. If true, Dr. Schiff says, this finding could help doctors more accurately calibrate the use of these devices.

This paper is a true tour de force of combining different models of physical behavior to re-examine some old standards,' says William Stacey, MD, Ph.D., associate professor of the department of neurology and biomedical engineering at the University of Michigan.

The combination of modeling with clever experimentation provided the very intriguing and unexpected result that heat might suppress neural firing. Perhaps this model might also provide some novel methods to manipulate neural activity.

Daniel M. Goldenholz, MD, Ph.D., assistant professor of epilepsy at Harvard, and author of a recent paper on why focal cooling is important for the future of treating focal epilepsy, found the results important as well.

I think the work from Dr. Schiff and colleagues highlights the great importance oftemperaturechanges inbraintissue and will likely be relevant in treatments of epilepsy that may include focal cooling. These fluctuations need to be better understood and accounted for if we want our therapies to become more accurate.

I would be very excited to see how Dr. Schiffs results are harnessed in the future for treatment of seizures and for neuromodulation, says Goldenholz.

Author: Jennifer ChenSource: YaleContact: Jennifer Chen YaleImage: The image is in the public domain

Original Research: Open access.Thermal effects on neurons during stimulation of the brain by TaeKen Kim et al. Journal of Neural Engineering

Abstract

Thermal effects on neurons during stimulation of the brain

All electric and magnetic stimulation of the brain deposits thermal energy in the brain. This occurs through either Joule heating of the conductors carrying current through electrodes and magnetic coils, or through dissipation of energy in the conductive brain.

Objective.

Although electrical interaction with brain tissue is inseparable from thermal effects when electrodes are used, magnetic induction enables us to separate Joule heating from induction effects by contrasting AC and DC driving of magnetic coils using the same energy deposition within the conductors. Since mammalian cortical neurons have no known sensitivity to static magnetic fields, and if there is no evidence of effect on spike timing to oscillating magnetic fields, we can presume that the induced electrical currents within the brain are below the molecular shot noise where any interaction with tissue is purely thermal.

Approach.

In this study, we examined a range of frequencies produced from micromagnetic coils operating below the molecular shot noise threshold for electrical interaction with single neurons.

Main results.

We found that small temperature increases and decreases of 1C caused consistent transient suppression and excitation of neurons during temperature change. Numerical modeling of the biophysics demonstrated that the Na-K pump, and to a lesser extent the Nernst potential, could account for these transient effects. Such effects are dependent upon compartmental ion fluxes and the rate of temperature change.

Significance.

A new bifurcation is described in the model dynamics that accounts for the transient suppression and excitation; in addition, we note the remarkable similarity of this bifurcations rate dependency with other thermal rate-dependent tipping points in planetary warming dynamics.

These experimental and theoretical findings demonstrate that stimulation of the brain must take into account small thermal effects that are ubiquitously present in electrical and magnetic stimulation.

More sophisticated models of electrical current interaction with neurons combined with thermal effects will lead to more accurate modulation of neuronal activity.

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Temperature Changes in the Brain Found to Affect Neuronal Activity - Neuroscience News

Infants Outperform AI in Commonsense Psychology – Neuroscience News

Summary: When it comes to detecting what motivates a persons actions, infants outperform current artificial intelligence algorithms. The findings highlight fundamental differences between computation and human cognition, pointing to shortcomings in current machine learning and identifying where improvements are needed for AI to fully replicate human behavior.

Source: NYU

Infants outperform artificial intelligence in detecting what motivates other peoples actions, finds a new study by a team of psychology and data science researchers.

Its results, which highlight fundamental differences between cognition and computation, point to shortcomings in todays technologies and where improvements are needed for AI to more fully replicate human behavior.

Adults and even infants can easily make reliable inferences about what drives other peoples actions, explains Moira Dillon, an assistant professor in New York Universitys Department of Psychology and the senior author of thepaper, which appears in the journalCognition. Current AI finds these inferences challenging to make.

The novel idea of putting infants and AI head-to-head on the same tasks is allowing researchers to better describe infants intuitive knowledge about other people and suggest ways of integrating that knowledge into AI, she adds.

If AI aims to build flexible, commonsense thinkers likehuman adultsbecome, then machines should draw upon the same core abilities infants possess in detecting goals and preferences, says Brenden Lake, an assistant professor in NYUs Center for Data Science and Department of Psychology and one of the papers authors.

Its been well-established that infants are fascinated by other peopleas evidenced by how long they look at others to observe their actions and to engage with them socially. In addition, previous studies focused on infants commonsense psychologytheir understanding of the intentions, goals, preferences, and rationality underlying others actionshave indicated that infants are able to attribute goals to others and expect others to pursue goals rationally and efficiently. The ability to make these predictions is foundational to human social intelligence.

Conversely, commonsense AIdriven bymachine-learning algorithmspredicts actions directly. This is why, for example, an ad touting San Francisco as a travel destination pops up on your computer screen after you read a news story on a newly elected city official. However, what AI lacks is flexibility in recognizing different contexts and situations that guidehuman behavior.

To develop a foundational understanding of the differences between humans and AIs abilities, the researchers conducted a series of experiments with 11-month-old infants and compared their responses to those yielded by state-of-the-art learning-driven neural-network models.

To do so, they deployed the previously established Baby Intuitions Benchmark (BIB)six tasks probing commonsense psychology. BIB was designed to allow for testing both infant and machine intelligence, allowing for a comparison of performance between infants and machines and, significantly, providing an empirical foundation for building human-like AI.

Specifically, infants on Zoom watched a series of videos of simple animated shapes moving around the screensimilar to a video game. The shapes actions simulated human behavior anddecision-makingthrough the retrieval of objects on the screen and other movements.

Similarly, the researchers built and trained learning-driven neural-network modelsAI tools that help computers recognize patterns and simulate human intelligenceand tested the models responses to the exact same videos.

Their results showed that infants recognize human-like motivations even in the simplified actions of animated shapes. Infants predict that these actions are driven by hidden but consistent goalsfor example, the on-screen retrieval of the same object no matter what location its in and the movement of that shape efficiently even when the surrounding environment changes.

Infants demonstrate such predictions through their longer looking to such events that violate their predictionsa common and decades-old measurement for gauging the nature of infants knowledge.

Adopting this surprise paradigm to study machine intelligence allows for direct comparisons between an algorithms quantitative measure of surprise and a well-established human psychological measure of surpriseinfants looking time.

The models showed no such evidence of understanding the motivations underlying such actions, revealing that they are missing key foundational principles of commonsense psychology thatinfantspossess.

A human infants foundational knowledge is limited, abstract, and reflects our evolutionary inheritance, yet it can accommodate any context or culture in which that infant might live and learn, observes Dillon.

The papers other authors are Gala Stojni, an NYU postdoctoral fellow at the time of the study, Kanishk Gandhi, an NYU research assistant at the time of the study, and Shannon Yasuda, an NYU doctoral student.

Author: Press OfficeSource: NYUContact: Press Office NYUImage: The image is in the public domain

Original Research: Open access.Commonsense psychology in human infants and machines by Gala Stojni et al. Cognition

Abstract

Commonsense psychology in human infants and machines

Human infants are fascinated by other people. They bring to this fascination a constellation of rich and flexible expectations about the intentions motivating peoples actions.

Here we test 11-month-old infants and state-of-the-art learning-driven neural-network models on the Baby Intuitions Benchmark (BIB), a suite of tasks challenging both infants and machines to make high-level predictions about the underlying causes of agents actions.

Infants expected agents actions to be directed towards objects, not locations, and infants demonstrated default expectations about agents rationally efficient actions towards goals. The neural-network models failed to capture infants knowledge.

Our work provides a comprehensive framework in which to characterize infants commonsense psychology and takes the first step in testing whether human knowledge and human-like artificial intelligence can be built from the foundations cognitive and developmental theories postulate.

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Infants Outperform AI in Commonsense Psychology - Neuroscience News

Domestic Abuse in Pregnancy Linked to Structural Brain Changes in … – Neuroscience News

Summary: Babies born to mothers who experience domestic violence during pregnancy have altered brain development and changes in brain structure. In females, maternal exposure to IPV was associated with a smaller amygdala, a brain area associated with social and emotional development. In males, the caudate nucleus size was increased. This brain area is associated with multiple functions including memory, learning, reward, and movement. The findings may explain why children of mothers who experience domestic abuse are more likely to suffer from mental health problems later in life.

Source: University of Bath

Domestic abuse against women during pregnancy can potentially have a significant impact on how the unborn babys brain develops, according to a new study.

Researchers at the University of Bath, working in collaboration with researchers from the University of Cape Town, analyzedbrain scansof 143 South African infants whose mothers had been subject tointimate partner violence(IPV) during pregnancy. Intimate partner violence includes emotional, physical and/or sexual abuse or assault.

Brain MRI scans were taken when infants were just 3 weeks old on average so any changes that were observed are likely to have developed inside the womb.

Publishing their findings in the journalDevelopmental Cognitive Neuroscience, the research team report thatmaternal exposureto IPV during pregnancy is associated with alterations inbrain structurein young infants identified shortly after birth.

This was evident even when the researchers took into account maternal alcohol use and smoking throughout pregnancy as well as pregnancy complications.

Importantly, the effects of IPV exposure may differ by the babys sex.

For girls, their mothers exposure to IPV during pregnancy was linked to a smaller amygdala, an area of thebraininvolved in emotional andsocial development.

For boys, IPV exposure was instead associated with a larger caudate nucleus, an area of the brain involved in multiple functions including the execution of movement, learning, memory, reward, and motivation.

Early changes to brain structures may explain why children whose mothers experience high levels of stress during pregnancy are more likely to have psychological issues in childhood or later life.

Sex differences in brain development may also help explain why girls and boys often develop different mental health problems. However, the researchers cautioned that the study did not analyze emotional andcognitive developmentin children.

Lead researcher, Dr. Lucy Hiscox from the Department of Psychology at Bath, explained, Our findings are a call to act on the three Rs of domestic violence awareness: recognize, respond, and refer. Preventing or quickly acting to help women escape domestic violence may be an effective way of supporting healthy brain development in children.

While previous studies have looked at the impact of maternal stress in pregnancy and its impacts on childrensbrain development, this is the first to examinedomestic abuse. The children involved in this study are now aged 8-9 years and follow-up research is testing whether the differences in brain structure seen at 3 weeks old persist, or are altered, as they age.

For this study, the team from Bath worked with researchers at the University of Cape Town (UCT) to analyze data from a major South African cohort study, the Drakenstein Child Health Study (DCHS), led by South African pediatrician Professor Heather Zar. The DCHS has been tracking 1,143 children since birth with data collection ongoing.

Co-author, Professor Kirsty Donald, a pediatric neurologist and Head of the Division of Developmental Pediatrics at UCT added, Strategies that help identify and support pregnant mums for multiple potential risks to their unborn babies will require an integrated health system approach and should be considered a public health priority.

Author: Andy DunneSource: University of BathContact: Andy Dunne University of BathImage: The image is in the public domain

Original Research: Open access.Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort by Lucy V. Hiscox et al. Developmental Cognitive Neuroscience

Abstract

Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort

Maternal psychological distress during pregnancy has been linked to adverse outcomes in children with evidence of sex-specific effects on brain development.

Here, we investigated whetherin uteroexposure to intimate partner violence (IPV), a particularly severe maternal stressor, is associated with brain structure in young infants from a South African birth cohort.

Exposure to IPV during pregnancy was measured in 143 mothers at 2832 weeks gestation and infants underwent structural and diffusion magnetic resonance imaging (mean age 3 weeks).

Subcortical volumetric estimates were compared between IPV-exposed (n=63; 52% female) and unexposed infants (n=80; 48% female), with white matter microstructure also examined in a subsample (IPV-exposed,n=28, 54% female; unexposed infants,n=42, 40% female).

In confound adjusted analyses, maternal IPV exposure was associated with sexually dimorphic effects in brain volumes: IPV exposure predicted a larger caudate nucleus among males but not females, and smaller amygdala among females but not males. Diffusivity alterations within white matter tracts of interest were evident in males, but not females exposed to IPV.

Results were robust to the removal of mother-infant pairs with pregnancy complications.

Further research is required to understand how these early alterations are linked to the sex-bias in neuropsychiatric outcomes later observed in IPV-exposed children.

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Spinal Cord Stimulation Instantly Improves Arm Mobility After Stroke – Neuroscience News

Summary: Spinal cord stimulation restores movement in the arms of stroke patients with locomotion problems, researchers report. The treatment has the potential to improve the quality of life for those who suffer arm paralysis following a stroke.

Source: University of Pittsburgh

A neurotechnology that stimulates the spinal cord instantly improves arm and hand mobility, enabling people affected by moderate to severe stroke to conduct their normal daily activities more easily, report researchers from the University of Pittsburgh and Carnegie Mellon University today inNature Medicine.

A pair of thin metal electrodes resembling strands of spaghetti implanted along the neck engage intact neural circuits, allowing stroke patients to fully open and close their fist, lift their arm above their head or use a fork and knife to cut a piece of steak for the first time in years.

We discovered that electrical stimulation of specific spinal cord regions enables patients to move their arm in ways that they are not able to do without the stimulation. Perhaps even more interesting, we found that after a few weeks of use, some of these improvements endure when the stimulation is switched off, indicating exciting avenues for the future of stroke therapies, said corresponding and co-senior author Marco Capogrosso, Ph.D., assistant professor of neurological surgery at Pitt.

Thanks to years of preclinical research building up to this point, we have developed a practical, easy-to-use stimulation protocol adapting existing FDA-approved clinical technologies that could be easily translated to the hospital and quickly moved from the lab to the clinic.

When it comes to strokes, doctors predict a grim future: Globally, every fourth adult over the age of 25 will suffer a stroke in their lifetime, and 75% of those people will have lasting deficits in motor control of their arm and hand, severely limiting their physical autonomy.

Currently, no treatments are effective for treating paralysis in the so-called chronic stage of stroke, which begins approximately six months after the stroke incident. The new technology, researchers say, has the potential to offer hope for people living with impairments that would otherwise be considered permanent.

Creating effective neurorehabilitation solutions for people affected by movement impairment after stroke is becoming ever more urgent, said senior co-author Elvira Pirondini, Ph.D., assistant professor of physical medicine and rehabilitation at Pitt.

Even mild deficits resulting from a stroke can isolate people from social and professional lives and become very debilitating, with motor impairments in the arm and hand being especially taxing and impeding simple daily activities, such as writing, eating and getting dressed.

Spinal cord stimulation technology uses a set of electrodes placed on the surface of the spinal cord to deliver pulses of electricity that activate nerve cells inside the spinal cord. This technology is already being used to treat high-grade, persistent pain. Additionally, multiple research groups around the world have shown that spinal cord stimulation can be used to restore movement to the legs after spinal cord injury.

But the unique dexterity of the human hand, combined with the wide range of motion of the arm at the shoulder and the complexity of the neural signals controlling the arm and hand, add a significantly higher set of challenges.

Following years of extensive preclinical studies involvingcomputer modelingandanimal testingin macaque monkeys with partial arm paralysis, researchers were cleared to test this optimized therapy in humans.

The sensory nerves from the arm and hand send signals to motor neurons in the spinal cord that control the muscles of the limb, said co-senior author Douglas Weber, Ph.D., professor of mechanical engineering at the Neuroscience Institute at Carnegie Mellon University.

By stimulating these sensory nerves, we can amplify the activity of muscles that have been weakened by stroke. Importantly, the patient retains full control of their movements: The stimulation is assistive and strengthens muscle activation only when patients are trying to move.

In a series of tests adapted to individual patients, stimulation enabled participants to perform tasks of different complexity, from moving a hollow metal cylinder to grasping common household objects, such as a can of soup, and opening a lock. Clinical assessments showed that stimulation targeting cervical nerve roots immediately improves strength, range of movement and function of the arm and hand.

Unexpectedly, the effects of stimulation seem to be longer-lasting than scientists originally thought and persisted even after the device was removed, suggesting it could be used both as an assistive and a restorative method for upper limb recovery. Indeed, the immediate effects of the stimulation enable administration of intense physical training that, in turn, could lead to even stronger long-term improvements in the absence of the stimulation.

Moving forward, researchers continue to enroll additional trial participants to understand which stroke patients can benefit most from this therapy and how to optimize stimulation protocols for different severity levels.

Additionally, Pitt and CMU-founded startup Reach Neuro is working to translate the therapy into clinical use.

Marc Powell, Ph.D., of Reach Neuro Inc.; Nikhil Verma, B.S., of Carnegie Mellon University; and Erynn Sorensen, B.S., of Pitt are co-first authors. Additional authors of the study are Erick Carranza, B.S., Amy Boos, M.S., Daryl Fields, M.D., Ph.D., Souvik Roy, B.S., Scott Ensel, B.S., Jeffrey Balzer, Ph.D., Robert Friedlander, M.D., George Wittenberg, M.D., Ph.D., Lee Fisher, Ph.D., and Peter Gerszten, M.D., all of Pitt; Beatrice Barra, Ph.D., of New York University; Jeff Goldsmith, Ph.D., of Columbia University; and John Krakauer, Ph.D., of Johns Hopkins University.

Funding: Research reported in this press release was supported by the NIH BRAIN Initiative under Award number UG3NS123135. The content is solely the responsibility of the authors and does not necessarily represent the official views ofthe National Institutes of Health. Additional research support was provided by the Department of Neurological Surgery and the Department of Physical Medicine and Rehabilitation at Pitt, and the Department of Mechanical Engineering and the Neuroscience Institute at Carnegie Mellon University.

Drs. Capogrosso, Gerszten, and Pirondini have financial interests in Reach Neuro, Inc., which has an interest in technology being evaluated in this study. These financial conflicts of interest have been reviewed and managed by the University of Pittsburgh in accordance with its Conflict of Interest Policy for Research.

Author: Anastasia GorelovaSource: University of PittsburghContact: Anastasia Gorelova University of PittsburghImage: The image is in the public domain

Original Research: Closed access.Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis by Marco Capogrosso et al. Nature Medicine

Abstract

Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis

Cerebral strokes can disrupt descending commands from motor cortical areas to the spinal cord, which can result in permanent motor deficits of the arm and hand. However, below the lesion, the spinal circuits that control movement remain intact and could be targeted by neurotechnologies to restore movement.

Here we report results from two participants in a first-in-human study using electrical stimulation of cervical spinal circuits to facilitate arm and hand motor control in chronic post-stroke hemiparesis (NCT04512690).

Participants were implanted for 29d with two linear leads in the dorsolateral epidural space targeting spinal roots C3 to T1 to increase excitation of arm and hand motoneurons.

We found that continuous stimulation through selected contacts improved strength (for example, grip force +40% SCS01; +108% SCS02), kinematics (for example, +30% to +40% speed) and functional movements, thereby enabling participants to perform movements that they could not perform without spinal cord stimulation. Both participants retained some of these improvements even without stimulation and no serious adverse events were reported.

While we cannot conclusively evaluate safety and efficacy from two participants, our data provide promising, albeit preliminary, evidence that spinal cord stimulation could be an assistive as well as a restorative approach for upper-limb recovery after stroke.

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What Neuroscience Tells Us About Insurrections | Essay – zocalopublicsquare.org

Research from the burgeoning field of neuropolitics supports the claim that political violencesuch as the recent uprising in Braziloriginates in a primitive part of the brain, linked to humans' fight-or-flight instinct. Political scientist and former biologist Matt Qvortrup explains. Courtesy of AP Newsroom.

by Matt Qvortrup|February21,2023

Why do people take part in insurrections, like the January 6, 2021 attack on the U.S. Capitol, the storming of the presidential residence in Sri Lanka, or Januarys sacking of Congress, the Supreme Court, and the presidential palace in Brazil?

Sometimes, that question is answered by pointing to precipitating eventselections and their results, protests that descend into anger, or the speeches of powerful demagogues. On other occasions, we blame insurrections on prejudices, or bigotriesracism, xenophobia, anti-Semitism, white nationalism.

Id suggest that we think about insurrections differentlybecause they originate in our brains.

Indeed, Id suggest that the insurrections in Washington, D.C. and Brasilia are due to overactivity in the limbic system in the braina primitive part of the brain that evolved millions of years ago, which we share with rats and cats and lizards and other creatures.

Social scientists used to focus on rational actions. But in recent years we have made great advances in understanding what goes on in the brain when we think politically. The biology of radical politics is no exception.

Scholars have explored why people rebel as long as there has been political science. In the early 1970s, one sociologist hypothesized that the reason was poverty, or relative deprivation. Political scientists and economists, using sophisticated mathematical models, also tried to explain rebellion, but found it hard to come up with a rational explanation. Very few people, the math showed, had any personal incentive to risk life and limb for the rather abstract benefits of overthrowing a government.

From a rational point of view, rebellions seem pointless. A political scientist even coined the phrase the paradox of revolution.

Enter neuroscience.

Since the early 2000s we have been able to look at what happens inside our heads when we think. Using functional magnetic resonance imaging (fMRI) scans which measure changing blood flow to brain cells, we can now see which parts of the brain get activated when we engage in various activities, like shopping, thinking about sex, and feeling remorse.

I started out as a biologist before becoming a political scientist. Together, those two different academic fields offer a similar lesson: To prevent rebellions and insurrections, we should avoid angry and polarized debate.

This perspective has also entered into the realm of political analysisfinally putting the science in political science. Of course, fMRI isnt useful for studying rebellions in real time; theres no way to scan peoples brains at the moment they storm the palace. But we can design experiments that observe how people who share insurrectionist views react to hate-speech and views that are articulated by politicians on the far right. Presenting subjects with statements about vulnerable minority groups during some brain scan studies, and showing them photos of political candidates they didnt agree with during others, researchers could literally see what happened in would-be insurrectionists brains.

When neurologist Giovanna Zamboni and colleagues conducted such an experiment a little over a decade ago, they found that a part of the brain known as the ventral striatum, which is associated with the limbic system, was activated when individuals who were identified by psychological tests as radicals were exposed to hate-speech statements or other intolerant assertions about other groups or minorities. These studies have been replicated in recent years and their findings confirmed and refined.

That the ventral striatum was activated is remarkable. This part of the brain is one of the oldest, in evolutionary terms. It is what makes animals respond positively to simple rewards in social situations and to negative stimuli in dangerous moments, such as fear that they might be attacked. The ventral striatum is linked with amygdala, the fight-and-flight center in the brain. When people hear statements aboutor see images ofgroups or individuals that they fear, the brain reacts as if it is attacked.

In contrast, study subjects who, based on personality tests, were identified as moderate or conservative used parts of the brain that only humans have evolved, such as the dorsolateral prefrontal cortex, which is responsible for planning and working memory and associated with listening, speaking, and reasoning. In another study, from 2011, young people with far-right views showed greater activation of amygdala, indicating that they were less likely to reflect on political statements and more likely to revert to fight-or-flight mode.

The most interesting part of this body of research: Generally, brains respond differently to politics than to policy. Scans show that when people think about politicsas in the rough and tumble partisan strugglethe fight-and-flight amygdala gets activated. But when people are exposed to questions about policy, they use the more advanced parts of the brain. In fMRI studies dating as far back as 2009, scientists found that the dorsolateral frontal cortex lit up in people exposed to arguments about economic policy.

I started out as a biologist before becoming a political scientist. Together, those two different academic fields offer a similar lesson: To prevent rebellions and insurrections, we should avoid angry and polarized debate. And when possible, we should avoid political hot-buttons and instead talk about the policy issues that affect our lives.

Biological research suggests the advantages of such an approach go beyond de-polarizing the public square. When we really listen to each other in debates about policy and related politics, we learn new things. And learning new things may make us less likely to develop degenerative conditions like Alzheimers and Parkinsons.

Humans are the product of 8 million years of evolution. We have the capacity to use the powers with which we have been endowed, namely to learn by being attentive, and through open deliberation. Human evolution hardwired us to process information, and make progress, through listening. But when we engage in hate speech and angry rebellion we revert to an evolutionarily primitive stage.

Neuropolitics shows us a way out of the current polarized debate and into a better future.

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What Neuroscience Tells Us About Insurrections | Essay - zocalopublicsquare.org