Dermatology Times 2023 In Review: Acne – Dermatology Times

New Pediatric Perspectives for Acne

Experts at Maui Derm Hawaii offer the latest findings and research in treating acne vulgaris in adolescents.

A new study also explores why the incidence of acne vulgaris is higher in girls than boys.

Study investigators evaluated the blood-brain barrier penetrance and lipophilicity of the narrow-spectrum, third-generation tetracycline-class oral antibiotic used for acne treatment.

Transgender and cisgender patients presenting with acne face differences in acne treatment and prescribing patterns.

Researchers say adolescents and young adults using the dermocosmetic product experienced improvements in their acne and quality of life.

Researchers say sun exposure plays a role in the exposome of acne-prone skin.

Researchers said the drug successfully altered C. acnes strains and more in a recent study.

Researchers said using the injections and mesotherapy in patients with acne more effectively treated their acne.

Researchers said the treatment may improve post-acne erythema.

Julie Harper, MD, shared updated risks and benefits of using spironolactone and oral contraceptives to treat acne in women at SCALE 2023.

Zeichner reviewed his top 3 acne treatment pearls at the Fall Clinical Dermatology Conference for PAs and NPs.

A poster presentation from the Fall Clinical Dermatology Conference for PAs and NPs evaluated the safety and efficacy of tazarotene for acne patients with skin of color.

During pregnancy and lactation, physiological changes occur in the body that can impact the development and management of acne.

With hormonal fluctuations, constantly changing schedules, and various afterschool activities, addressing the specific needs of teenage skin becomes essential to promote a lifetime of proper skin care practices.

Catch up on acne vulgaris treatment pearls from Dermatology Times most recent Frontline Forum series, featuring James Del Rosso, DO; Hilary Baldwin, MD; Neal Bhatia, MD; Christopher Bunick, MD, PhD; and Leon Kircik, MD.

Yale School of Medicine researchers found tetracycline-class antibiotics were the most prescribed acne treatment for adult female patients between 2002 and 2016.

The impact of acne conglobata on individuals underscores the crucial role dermatologists play in providing effective diagnosis, treatment, and emotional support.

The US Food and Drug Administration has approved IDP-126 gel for patients with acne.

The Sun Pharma survey included 1003 respondents with mild to moderate acne.

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Dermatology Times 2023 In Review: Acne - Dermatology Times

Reviewing the Top Dermatology Headlines of 2023 – Dermatology Times

FDA Accepts sNDA for Arcutis' Roflumilast Cream 0.15% for Atopic Dermatitis, Sets July 2024 PDUFA Date

The sNDA is supported by positive data from the phase 3 INTEGUMENT-1 and INTEGUMENT-2 trials.

The FDAs PDUFA target date is May 25, 2024.

Immunotherapies, including PD-1 checkpoint inhibitors such as nivolumab, have improved the treatment options for patients with advanced melanoma.

There are currently no FDA-approved therapies for the rare, genetic disease.

Christopher Bunick, MD, PhD, and David Light, CEO of Valisure, weigh in on the proposed formaldehyde ban.

The approved indication makes Wezlana the first approved interchangeable biosimilar to Stelara.

Secukinumab is currently the only IL-17A inhibitor approved for the condition.

The US Food and Drug Administration has approved IDP-126 gel for patients with acne.

The CRL states that additional efficacy data is needed in order to support approval.

Bimekizumab is now the first and only approved IL-17A and IL-17F inhibitor for this indication.

Kyverna Therapeutics can now initiate its phase 1/2 open-label, multicenter study of KYV-101.

The approval provides pediatric patients with a steroid-free topical therapy.

No concerns were cited about the clinical data package, safety, or label of lebrikizumab.

Abeona Therapeutics is seeking Priority Review and approval of the therapy for patients with recessive dystrophic epidermolysis bullosa.

From its clinical study, 97% of patients saw improvement in acne scars after 3 treatment sessions.

The topical cream is the first epidermolysis bullosa treatment to receive Breakthrough Therapy designation from the FDA.

Beremagene geperpavec is the first FDA-approved treatment for DEB, a rare and burdensome disease.

Ritlecitinib is the first and only treatment cleared for adolescents with severe alopecia areata.

Patients can achieve reduced excessive underarm sweating after one in-office treatment.

The expanded approval is based on data from a recent phase 3 clinical trial.

The picosecond system has previously been approved for treating acne scarring, pigmented lesions, tattoo removal, and wrinkles.

Verricas VP-102 is the first FDA-approved treatment for molluscum lesions.

Jared Gollob, MD, Chief Medical Officer of Kymera Therapeutics, spoke with Dermatology Times to discuss these trial results.

Germany will be the first country where lebrikizumab will be available for prescription, with a subsequent rollout across European countries throughout 2024.

Timber Pharmaceuticals has been developing TMB-001 for the treatment of congenital ichthyosis.

This month's cover feature delves into the new applications and use of AI in dermatology and considers how AI can support clinicians rather than hinder them.

See any important headlines we may have missed this year? Share with us by emailing our team at DTEditor@mmhgroup.com.

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Reviewing the Top Dermatology Headlines of 2023 - Dermatology Times

Decision Fatigue in Emergency Medicine: An Exploration of Its Validity – Cureus

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Decision Fatigue in Emergency Medicine: An Exploration of Its Validity - Cureus

New Year’s Eve safety tips, straight from emergency department doctors – Newsday

New Years Eve,thatbusy night of revelry,food and drink with friends and loved ones,also canbe a hectic time at hospital emergency departments when the fun goesawry.

Doctors say this is the time of year they see an increase in car crashes, intoxication cases and even accidents in the kitchen.

Newsday spoke with several emergency department doctors on Long Island about common holiday hazardsandhow people can celebrate and stay safe.

Injuries due to vehicle accidents increase every year around New Years Eve, said Dr. Neil K. Dasgupta, director of Emergency Critical Careat Nassau University Medical Center.

Its the holidays everyones stressed, everyone's busy, things are crowded, Dasgupta said. There are a lot of traffic accidents, whether they are related to alcohol or not. People are out trying to get places and they are not paying attention. There is a lot more traffic on the road.

The National Safety Council estimates that 375 people may die on U.S. roads during the New Years Day holiday period, which lasts from Friday through Monday. Alcohol consumption is a major contributing factor.

Doctors suggest designating a driver who will abstain from alcohol for the night, or using a ride share service. If possible, stay off the roads to avoid dangerous drivers.

Really, there is no safe amount [of alcohol]if you are driving, said Dr. Matthew Projansky, associate chair of emergency medicine for Plainview Hospital and Syosset Hospital.

There are a lot of alcohol-related cases that come into the emergency room every New Years Eve, Projansky said. A lot of teenand underage drinking takes place,he said. [Teens]are usually more susceptible to the effects of alcohol because they dont drink regularly.

Some patients require IV fluids to hydrate,and time, but others who are vomiting and aspirating may need more serious medical intervention, doctors said.

Excessive alcohol consumption also could lead to a condition known as holiday heart, said Dr. Robert Schwaner, medical director of the department of emergency medicine and chief of the division of toxicology at Stony Brook University Hospital.

Alcohol is a direct irritant to the heart, he said. If someone binges on alcohol over a week or two, its not uncommon to get atrial fibrillation," an irregular heart rate that impacts blood flow.

Projansky said he also sees more trips and falls, and twisted ankles, sometimes due to people wearing high-heeled shoes.

"Even if you aren't drunk, your balance might be a little off," he said.

Using knives and other sharp utensils to prepare meals;washing glasses;falling down stairs and even popping the cork can lead to injuries that land people in emergency rooms every New Years Eve.

A big one we see all the time is people trying to clean glasses who are intoxicated, Schwaner said. Then they break the wine glass and cut their hand.

And when you have 50 champagne corks going off in a room, it can definitely cause some injuries, Dasgupta said.

He said some people choose dangerous ways fireworks and even firearms to celebrate the holidays.

Make sure you are around people who you trust, Dasgupta said. Keep your phone charged and stay in touch with your friends and family.

Schwaner suggests everyone have a plan to keep an eye on each other, travel safely and dress appropriately for the weather. No one wants to be stranded, he said, especially since temperatures are expected to dip into the 30s on Sunday night.

Hypothermia is a real issue, he said.

Projansky pointed out that people who are drunk may not even realize they are hypothermic.

Whiskey going down feels warm, but alcohol doesnt raise your body temperature, he said. It actually lowers it.

Lisa joined Newsday as a staff writer in 2019. She previously worked at amNewYork, the New York Daily News and the Asbury Park Press covering politics, government and general assignment.

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New Year's Eve safety tips, straight from emergency department doctors - Newsday

Emergency room doctor unveils the most dangerous toys this season – WTOP

Children's National Hospital emergency medicine physician and director of outreach Sarah Ash Combs shares what gifts parents should avoid this Christmas.

In less than 24 hours kids everywhere will begin tearing into toys from their wish list. But before that happens, one D.C.-area doctor suggested some ways to play it safe and avoid a Christmas trip to the emergency room.

Dr. Sarah Ash Combs, an emergency medicine physician and director of outreach for Childrens National Hospital, said there is an easy way for parents to make sure toys are safe. It begins with carefully checking the toys packaging and wrapping especially if you have children younger than three years old.

Is it wrapped in shrink-wrap packaging? she said. Is it something that a young child can get their hands on and ingest and use to cover their mouths? Bear in mind what the toy is coming in.

Combs also suggested keeping toys with tiny magnets, loose buttons or coin batteries away from children. If those parts are swallowed, they could be deadly for kids.

Look at a toy critically, Combs said. Ask yourself, If this went into my childs mouth, could be sucked down into the back of their throat? If you are saying yes, I would just put those toys to one side.

Another toy that strikes fear in the hearts of emergency room physicians, especially with New Years Eve on the horizon, is balloons.

If ingested, Combs said, balloons can cut off a childs airway and cause suffocation.

We really like to veer away from too many balloons lying around, especially in a young childs house, she said.

For larger kids, Combs advised parents to avoid gifting trampolines and rocket launchers this holiday.

The risk with trampolines is that children can land wrong on their heads or necks, or fall and break a bone. And toys that propel objects can cause severe close-range injuries, Combs told WTOP.

She said strict parental supervision is key.

Bear in mind, were talking about a minority of toys to stay away from, with the idea that this will give you a joyful holiday, she said. So that youre not coming to visit me in the emergency department.

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Emergency room doctor unveils the most dangerous toys this season - WTOP

Emergency physician jobs: Navigating tech’s impact on healthcare – Arizona Big Media

Step into the next future of healthcare transformation. A revolution that is reshaping emergency physician jobs and patient care.

Prepare to embark on a journey as we navigate the thrilling evolution. Uncovering the impacts of cutting-edge advancements.

Join us as we delve into this progressive landscape. Where healthcare tech revolutionizes the healthcare sector. It also redefines the scope and practice of emergency medicine. Brace yourself for an exploration of how innovation is shaping healthcare.

Lets dive in!

EHRs have transformed healthcare by replacing paper records. It can now be accessed with efficient and secure digital systems. It allows for quick access to medical information.

It will enable healthcare providers to make timely and accurate diagnoses. This further reduces errors and improves patient outcomes.

These apps have revolutionized emergency physician jobs. It offers advanced that include the following.

These apps empower individuals to enhance their health and well-being.

Telemedicine has sparked a radical transformation in the role of emergency healthcare. It uses video conferencing, remote monitoring, and secure messaging.

Doctors can now deliver consultations to patients from a distance. This improves access to healthcare services.

Telemedicine provides immediate support to paramedics. It also aids in triage operations during times of disaster. Websites like https://www.abstaffing.com/ offer the availability of travel nurses.

They also offer physician assistants and nurse practitioners to assist in emergencies. This tech influence expands the scope and reduces response times in critical situations.

Growth in diagnostic tools and imaging has improved emergency medicine. It provides real-time data at the bedside. These aid in quick diagnosis and decision-making, leading to better patient care.

These could include:

A technology impact is revolutionizing emergency medicine. It provides heart rate monitoring, fall detection, and even ECG capabilities. Devices like fitness trackers and smartwatches offer valuable data for emergency physicians.

This enables remote monitoring of high-risk individuals. This also gives valuable insights into patients health.

The future of healthcare lies in the USE of AI. This technology has already made significant strides in analyzing medical data. It also includes identifying patterns and predicting diagnoses.

In emergency medicine, AI is being utilized to assist in decision-making. This aids physicians in providing faster and more accurate care.

Growth in robotics has transformed emergency physician jobs. It helps aid in surgeries and provides remote support for patients.

Robots can also be utilized to transport medical supplies and perform tasks. This frees up physicians to focus on critical patient care.

VR technology is revolutionizing medical training and education for emergency physicians. Immersive simulations allow for hands-on learning. It also allows practicing high-risk procedures without putting patients at risk.

VR is also being used to manage pain and anxiety in patients. This further reduces the need for sedation and medication.

Groundbreaking advancements are transforming emergency physician jobs. This includes the likes of AI, telemedicine, and robotics. These innovations enhance diagnostics and patient engagement.

It also helps redefine the role of emergency physicians. The future of emergency medicine holds limitless potential driven by innovation.

Stay informed and explore the fascinating impact of technology on healthcare.

Browse our blog for more interesting reads.

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Emergency physician jobs: Navigating tech's impact on healthcare - Arizona Big Media

7 New Year’s Resolutions for Heart Health From Cardiologists – Livestrong

If you're over 40, make an appointment this year to get your heart checked.

Image Credit: andreswd/E+/GettyImages

February is American Heart Month, but you don't have to wait until then to show your heart some love.

Heart disease is still the leading cause of death in the U.S., per the Centers for Disease Control and Prevention (CDC), so it's important to stay on top of your heart health in any way you can.

We asked cardiologists what resolutions they'd like patients to make in regards to their hearts year. Here's what they said:

As with most New Year's resolutions, we start out super motivated in January with diet and exercise goals, then lose momentum as the days go by.

This year, try to be more realistic about your resolutions. This can set you up for consistent, long-term changes in your health, which will ultimately protect your heart in the long term, too.

Case in point: "Diets [and exercise] that begin in colder months fail more than those that begin in the spring," says Allan Stewart, MD, a cardiac surgeon in Miami, Florida. "A great New Year's resolution is to set modest, realistic goals from January to March, and then as you succeed, ramp up those goals in the spring."

For example, maybe a 10,000-step-per-day goal is unrealistic in the wintertime, so start with 5,000 per day and increase as the weather gets warmer.

Only 1 in 10 Americans eat the recommended amount of produce per day, according to the CDC.

But eating enough fruits and veggies reduces your risk of having (and dying from) heart disease and a stroke by up to 27 percent, per an October 2020 meta-analysis in the Journal of the American Heart Association.

One doable way to eat more produce? "Add a piece of fresh fruit to your breakfast and a side of veggies to lunch and dinner," says Karishma Patwa, MD, a cardiologist with Manhattan Cardiology in NYC and contributor to LabFindDieter.

Another bonus: Eating more produce aligns with the Mediterranean diet, which has been shown to be beneficial for your heart, per the Mayo Clinic.

"The five major risk factors for heart disease high cholesterol, high blood pressure, high blood sugar, overweight and poor diet are often food-related," says Elizabeth Klodas, MD, FACC, a preventive cardiologist in Edina, Minnesota, and creator of Step One Foods.

"Changing your diet is especially powerful, but I'm not asking anyone to turn their life upside down," Dr. Klodas says.

Instead, plan to add one nutritious food and remove one not-so-nutritious food from your diet each day.

This could look like eating an apple a day and removing a can of soda each day (or whatever is applicable to your diet). While one day of change won't do much, sticking with this habit over the course of a year is very beneficial.

Dr. Klodas also mentions this two-per-day approach has helped people significantly reduce their "bad" LDL cholesterol within 30 days. This method was also supported by February 2020 research in The Journal of Nutrition.

The Physical Activity Guidelines for Americans recommend getting 150 minutes of moderate-intensity exercise every week for optimal health, per the CDC, which equals about 30 minutes of activity five days per week.

"If this amount feels daunting, you can try to break it into shorter bursts of exercise," Dr. Patwa says.

She recommends taking small, two- to three-minute walks every hour. If you spend eight hours of the day sitting at a desk, for example, that's about 24 minutes of walking a day almost at the goal. Plus, you'll be giving your body a much-needed break from sitting still.

Alcohol in any amount is associated with a higher risk of heart disease, according to a March 2022 study in JAMA Network Open.

If you've tried to commit to a "dry" January (where you don't drink alcohol for the month) and have missed the mark, know that this is the ideal year to do it, Dr. Stewart says. That's because "New Year's Day is a Monday," he says.

Many people see Monday as the day to start fresh and kick off healthier habits. In contrast, Dr. Stewart says when the day falls on a Friday or Saturday, it's more difficult to start dry January, especially because the New Year parties can keep going through the weekend.

If you feel you've overindulged in alcohol over the holidays (as many of us do), dry January can give you a break. Plus, it gives you a chance to reevaluate your relationship with alcohol.

Keep in mind: This means you may have to change up how you socialize with friends, so planning is key, Dr. Stewart says. And try to avoid counting down the days until February 1, he adds.

"It's important not to count down the days until January 31, as it somewhat defeats the purpose of the potential joy you could feel in the process, or the potential to stay sober [beyond January 31]," he says.

If the hectic holiday season left you even more sleep-deprived than you already were, let January be the time you get into a good sleep schedule.

When we're low on sleep, we tend to reach for "quick pick-me-ups like caffeine and sugar," Dr. Klodas says, which can lead to heart palpitations and other issues.

The American Heart Association suggests getting seven to nine hours of sleep per night, as well as getting treated for sleep disorders, such as insomnia, restless leg syndrome or sleep apnea.

To that end: "Non-restorative sleep, especially when due to sleep apnea, can be a major contributor to high blood pressure," Dr. Klodas says, which is a risk factor for heart disease, heart attack and other serious health conditions.

If you, your bed partner or someone in your household suspects you have a sleep disorder (because you snore, talk in your sleep or stop breathing during sleep), this may be the year to finally get a sleep study done and treat the problem.

Are you over 40? If so, Dr. Patwa recommends going to the cardiologist for a preventive screening.

This can help ensure your heart's working properly.

If your doctor has any concerns about your heart, they may run tests such as an electrocardiogram, echocardiogram or stress test, which are the best ways to pick up on heart disease, Dr. Patwa says.

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7 New Year's Resolutions for Heart Health From Cardiologists - Livestrong

Creatinine and Cystatin C-based GFR Estimation in HF Mortality – Physician’s Weekly

The following is a summary of Prognostic Value of Creatinine versus Cystatin C-Based Estimation of Glomerular Filtration Rate for Mortality in Heart Failure, published in the November 2023 issue of Cardiology by Roehm et al.

Researchers conducted a retrospective study to examine heart failure with reduced ejection fraction (HFrEF) data, comparing the prognostic power of creatinine and cystatin C-based estimated glomerular filtration rate (eGFR), alone and combined, to pinpoint the most accurate predictor of mortality.

They examined data from 310 participants in the Registry Evaluation of Vital Information for Ventricular Assist Devices in Ambulatory Life with baseline serum creatinine and cystatin C. The primary outcome was all-cause mortality. Cox models were adjusted for age, gender, race, diabetes mellitus, and NYHA class.

The results showed median eGFR by cr, cys, and cr-cys were 60, 58, and 60 ml/min/1.73m2, respectively. In the 2-year follow-up, 45 participants died, with eGFRcr and eGFRcys differing by -49 to 50 ml/min/1.73m2 within each patient. Worse survival was observed for estimates with baseline eGFR <60 ml/min/1.73m2. Lower baseline eGFRcr [HR 0.97, 95% CI (0.96-0.99), P =0.008, C 0.67], eGFRcys [HR 0.98 (0.97-0.99), P= 0.006, C= 0.68], and eGFRcr-cys [HR 0.98 (0.96-0.99), P= 0.004, C= 0.68] correlated with higher mortality. C-statistic comparisons revealed no significant difference in predictive ability: eGFRcr vs. eGFRcys, P=0.7; eGFRcr vs. eGFRcr-cys, P=0.9; eGFRcys vs. eGFRcr-cys, P=0.3).

They concluded that eGFR was linked to HFrEF death, but creatinine and cystatin C flunked as accurate predictors.

Source: ahajournals.org/doi/10.1161/circ.148.suppl_1.17090

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Creatinine and Cystatin C-based GFR Estimation in HF Mortality - Physician's Weekly

Smidt Heart Institute at Cedars-Sinai opens Aortic Surveillance Clinic for patients with enlarged aortas – News-Medical.Net

The Smidt Heart Institute at Cedars-Sinai has opened an Aortic Surveillance Clinic for the evaluation and long-term monitoring of patients with enlarged aortas, or aortic aneurysms, for whom surgery may not be necessary.

The clinic is the newest offering from the heart institute's dedicated Aortic Program, an interdisciplinary team of highly specialized cardiologists, cardiac and vascular surgeons, radiologists, genetic counselors, and nurses treating the full spectrum of aortic disorders.

"When patients hear that they have an aortic aneurysm, they often think they are ticking time bombs, but that is not always the case," said Robbin Cohen, MD, professor of Cardiac Surgery and director of the Cardiac Surgery Program at Huntington Health, a Cedars-Sinai affiliate. "Most of the patients that we see-;many with genetic conditions affecting the heart-;have aortas that are not large enough or serious enough to need surgery, but they do require ongoing monitoring.

"Through the Aortic Surveillance Clinic, we offer reassurance that they are being carefully and closely monitored and that proper therapy, including surgery, will be offered if needed."

Smidt Heart Institute patients benefit from access to a multidisciplinary team including cardiac and vascular surgeons skilled in treating a range of aortic conditions.

We take pride in our collaborative approach, which benefits patients with various complex aortic diseases. Our team is versed in innovative, minimally invasive procedures, in which cardiac surgeons and vascular surgeons are thorough and thoughtful in how best to manage each individual patient's needs."

Ali Azizzadeh, MD, vascular surgeon, professor and director of Vascular Surgery, associate director of the Smidt Heart Institute at Cedars-Sinai and an aortic aneurysm expert

Cohen has more than 25 years of experience monitoring and treating patients with aortic aneurysm.

"Aortic surgeons know that over time, they will accumulate hundreds of patients with aneurysms that they are following and not operating on," Cohen said. "This requires expertise in aortic imaging, the natural history of aortic disease, and the guidelines and criteria for surgery-;areas in which the Smidt Heart Institute team is highly skilled."

The aorta is the largest and most important artery. It carries blood away from the heart into the rest of the body. Careful monitoring of a significantly enlarged aorta, or aortic aneurysm, can help prevent the possibility of a life-threatening condition, such as aortic dissection-;a tear that develops along the inner layer of the aorta.

The Aortic Surveillance Clinic also provides expert care for patients with certain genetic syndromes, such as connective tissue disorders like Marfan syndrome and Loeys-Dietz syndrome, as well as other genetic disorders affecting the aorta and aortic valve, such as Turner syndrome. These patients are at high risk of developing an enlarged aorta and subsequently, a tear or dissection in the aorta due to abnormalities in the heart and blood vessels. Because these disorders also can affect other areas of the body, the Aortic Surveillance Clinic goes a step further and addresses these issues by connecting patients with genetic counselors, ophthalmologists, orthopedists, psychologists, reproductive endocrinologists and other specialists, as needed.

"We are pleased to have the ability to focus on a subset of patients when they don't need surgery-;and educate them on how to prevent acute aortic events, which can be fatal," said Joanna Chikwe, MD, chair of the Department of Cardiac Surgery and the Irina and George Schaeffer Distinguished Chair in Cardiac Surgery in the Smidt Heart Institute at Cedars-Sinai. "And if these patients do need surgery-;which can be complex and challenging-;the Smidt Heart Institute has the expertise of a comprehensive, multidisciplinary team to take care of them, with superb results."

The Aortic Surveillance Clinic is located at 127 San Vicente Blvd., in Los Angeles and is open for patient evaluation the second Friday of each month. Patients can call 310-423-3851 for more information.

Cedars-Sinai once again has been recognized by U.S. News & World Report, this year as the #2 program in the nation for Cardiology, Heart & Vascular Surgery. The Smidt Heart Institute is also #1 for Cardiology, Heart & Vascular Surgery in California and Los Angeles (highest U.S. News ranking in the region).

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Smidt Heart Institute at Cedars-Sinai opens Aortic Surveillance Clinic for patients with enlarged aortas - News-Medical.Net