Concerns over public health heighten as trainee doctors walk off job for 2nd day –

An emergency room at a military hospital in Pohang, 262 kilometers southeast of Seoul, Feb. 20. Yonhap

Surgeries have been canceled and some patients were forced to be transferred to other hospitals as trainee doctors stopped working for the second day in a row Wednesday in protest of the government's plan to boost the number of medical students.

More than 6,400 trainee doctors nationwide, about 55 percent of the junior doctors, have submitted their resignations en masse so far, with about 1,600 of them walking off the job, according to the health ministry.

Medical services at the five biggest general hospitals in Seoul suffered partial disruptions Tuesday after interns and resident doctors did not show up for work following collective resignations as they protested the plan to raise the medical school admission quota by 2,000 seats next year.

To cope with a potential disruption to medical services, the government has extended operating hours at 97 public hospitals and opened emergency rooms at 12 military hospitals to the public.

"We are deeply disappointed and concerned that the collective action by trainee doctors has led to a disruption in medical services, such as the cancellation of surgeries," Second Vice Health Minister Park Min-soo told reporters.

"We cannot give justification to the actions of the doctors leaving their patients behind to protest a policy despite knowing what the collective action could result in," Park said.

Despite the government's back-to-work order, trainee doctors have shown no sign of backing down.

In a statement, the Korean Intern Resident Association, a major organization of trainee doctors, demanded the government withdraw the plan to increase the number of medical students.

Describing the plan as "ridiculous," the association criticized the government for treating trainee doctors as "criminals by overusing extrajudicial executive orders."

The government says the increase in the admission quota is needed to address a shortage of doctors, particularly in rural areas and essential medical fields, such as high-risk surgeries, pediatrics, obstetrics and emergency medicine.

The number of doctors in South Korea relative to the size of the population is among the lowest in the developed world, according to health authorities.

But doctors have claimed that the government has not had full consultations on the matter and that the move will compromise the quality of medical education and services. (Yonhap)

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Concerns over public health heighten as trainee doctors walk off job for 2nd day -

Analyzing the Gender’s Impact on ED HEART Scores – Physician’s Weekly

The following is a summary of Influence of Patient and Clinician Gender on Emergency Department HEART Scores: A Secondary Analysis of a Prospective Observational Trial, published in the February 2024 issue of Emergency Medicine by Barron, et al.

Healthcare gaps can be reduced with the help of clinical decision tools. However, many clinical decision tools have subjective factors that could bring bias from the doctor. The HEART score is a clinical decision that helps doctors tell how likely a patient in the emergency department (ED) will have a heart attack.

For a study, researchers sought to find out how gender affects HEART scores for both patients and clinicians.

They looked at a random group of adult ED patients at one hospital who came in with signs of acute cardiac syndrome in this secondary analysis of a prospective observational study. They looked at HEART scores made by ED clinicians and scores made by researchers who didnt know what gender the patient was. The main result was whether the HEART numbers given by the physician and researcher were the same for each patients gender and each therapists gender. They used difference-in-difference (DiD) to compare continuous scores and prevalence-adjusted, bias-adjusted Kappa (PABAK) to compare binary scores (low risk vs. moderate/high risk). All 336 pairs of clinicians and patients from the original study were considered. 47% of the patients were women (158/336), and 52% were handled by women clinicians (174/336).

The difference between the doctors and researchers HEART scores for male and female patients was 0.24 (95% CI 0.01 to 0.48). They found that male clinicians gave male patients a higher score than female patients (DiD 0.51 [95% CI 0.16 to 0.87]), but female clinicians did not (DiD 0.00 [95% CI 0.33 to 0.33]). It was most agreed upon between female clinicians (PABAK 0.72; 95% CI 0.61 to 0.81) and least agreed upon between male clinicians evaluating male patients (PABAK 0.47; 95% CI 0.29 to 0.66). The gender of the patient and the doctor may affect the HEART score. When this and other professional decision aids are being made and used, researchers should try to understand these factors.

Source: sciencedirect.com/science/article/abs/pii/S0196064423001993

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Analyzing the Gender's Impact on ED HEART Scores - Physician's Weekly

LifeFlight makes significant investment in strengthening EMS and hospital partnerships – Boothbay Register

LifeFlight of Maine has launched a significant new initiative to bolster its relationships with hospitals, first responders, emergency medical services (EMS), 911 centers, and other stakeholders that rely on LifeFlight to deliver critical care quickly and reliably for patients facing a life-threatening medical emergency.

This initiative will be led by Kyle Madigan, director of client relations at LifeFlight of Maine, who began in this newly created role in January 2024. Madigan brings decades of experience as a flight nurse and critical care provider, an educator, and an air medical program administrator. Most recently, he led the Dartmouth Hitchcock Advanced Response Team (DHART), LifeFlight of Maines peer service based in Lebanon, New Hampshire.

Under Madigans leadership, LifeFlight is working to expand its outreach and education efforts across all 16 counties in Maine, as well as parts of New Hampshire along the border with Maine, an area in which LifeFlight of Maines Sanford-based team provides service when needed. These efforts include expanding offerings of LifeFlights Ground Safety and User Course, which trains partner agencies on how to identify when a patient needs a LifeFlight transport, how to make a transport request, how to safely secure a landing zone, and how to transfer the patient into LifeFlights care.

Madigan, in concert with LifeFlight of Maine CEO Joe Kellner, is also leading efforts to strengthen operational collaboration between LifeFlight and Maines hospitals. The majority of calls to LifeFlight come from a hospital requesting to transfer an acutely ill patient to a facility that offers a higher level of care. This is a critically important service for Maines geographically dispersed system of community hospitals. The smooth, reliable, and rapid movement of these patients in a LifeFlight vehicle is critical both to the patients outcomes and to the capacity of the emergency medical system statewide to ensure all patients can access the care they need. Madigan will work with leaders and clinicians in emergency departments and intensive care units to improve coordination and logistics for the care teams interfacing with LifeFlight crews.

Additionally, LifeFlight is working with communities, first responders, and private citizens to establish additional helicopter landing zones in rural areas. LifeFlight maintains a database of thousands of landing zones across Maine and parts of New Hampshire, which LifeFlight crews utilize to respond to medical emergencies. Many of these landing zones are a local ball field or parking lot. Others are a clearing deep in the Maine woods. By working with communities to expand this database, which is available both to LifeFlight and to 911 dispatchers statewide, LifeFlight is creating more critical healthcare access points across Maine.

At LifeFlight of Maine, we hold ourselves to uncompromising standards of excellence. This is what has inspired this organization for two and a half decades, and what continues to drive us as one of the premier nonprofit air ambulance and critical care services in the country. We are continually looking for ways to elevate the level of care we provide to our patients, and to improve the reliability and speed of the service we offer to every community here in Maine. This new initiative continues our longstanding commitment to excellence, said Joe Kellner, CEO, LifeFlight of Maine.

Kyle Madigans experience and expertise in the delivery of critical care emergency medicine is formidable. The work he is doing to strengthen collaboration between LifeFlight and our EMS and hospital partners is a tremendous asset both to this organization and to the entire Maine EMS system, fundamentally because this initiative will improve patient care and save lives, said Bill Cyr, COO, LifeFlight of Maine.

I have dedicated my career to nonprofit, critical care emergency medicine, because I firmly believe that this is the best delivery model for patients in Maine, northern New England, and beyond. I have worked in collaboration with my colleagues at LifeFlight of Maine for years, and Im pleased to now have the opportunity to serve alongside them. Maine is fortunate to have an air medical provider as well-regarded as LifeFlight, and I look forward to contributing my skills to this team and to the State of Maine, said Kyle Madigan, director of client relations, LifeFlight of Maine.

LifeFlight of Maine is a nonprofit and the states only air ambulance service. Since 1998, LifeFlight has transported more than 38,000 patients, one life at a time, from every community in Maine. LifeFlights mission is to transform the critical care transport medicine system into an integrated, high-quality, patient-centered system worthy of the publics trust. LifeFlights airplane and five helicopters are based in Bangor, Lewiston, and Sanford. Along with dedicated ground ambulances, these vehicles cover the entire state and offshore islands. LifeFlight complements and supports the work of local EMS and hospital personnel in caring for the critically ill or injured. Each LifeFlight base is staffed by a highly qualified team of pilots, flight nurses and flight paramedics, EMT vehicle operators, aviation maintenance technicians, and communications specialists. LifeFlight of Maine is a joint venture partnership of Central Maine Healthcare and Northern Light Health. LifeFlight was fully re-accredited by the Commission on Accreditation of Medical Transport Systems in 2022. More information about LifeFlight of Maine is available at LifeFlightMaine.org.

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LifeFlight makes significant investment in strengthening EMS and hospital partnerships - Boothbay Register

Steward Health Care news: ER near Boston put patients in jeopardy – The Boston Globe

Two weeks after the patients death on Sept. 13, state health inspectors arrived at the hospital, owned by for-profit Steward Health Care, to investigate. During their review of patient records, they found an emergency department with recurring staffing problems that at times seemed to be in near-meltdown.

Extremely sick patients had no assigned nurses, including one patient who was previously found unresponsive in a hallway. In another instance, an overworked nurse who was extremely busy and was behind, trying to catch up left a patient who had been vomiting in the waiting room for more than 10 hours. A friend discovered the patient barely conscious; the person was intubated and admitted to the intensive care unit, according to a state inspection report. It is unclear from the report if those patients survived, and hospital officials declined to provide that information.

State and federal officials declared the safety lapses put patients in immediate jeopardy, a severe sanction that required Good Samaritan to develop a plan within 23 days to fix its emergency department or risk losing its Medicare funding. Good Samaritan executives said they addressed the problems immediately, including bringing in more staff.

The hazards in the hospitals emergency department should not have been a surprise to state and federal regulators. Inspectors for the Massachusetts Department of Public Health had found serious patient safety violations in Good Samaritans emergency department three other times since 2021, documents obtained by the Globe show. After each inspection, investigators required the hospital to produce an improvement plan, but their visits resulted in little lasting change.

It wasnt until Jan. 31, when the seriousness of the financial crisis engulfing the company had become public, that the health department began sending daily monitors to Good Samaritan and other Steward hospitals, raising concerns about why the state didnt do more sooner.

While emergency departments are under strain across Massachusetts and the country, staff at Good Samaritan have been especially overwhelmed as they try to treat thousands of additional patients after two nearby hospitals shut their doors. At the same time, nurses have told state inspectors that private equity-backed Steward has neglected to hire enough staff and buy enough supplies.

The Massachusetts Nurses Association, the union that represents nurses at the hospital, warned state and federal health officials in 2021 and 2022 about the deterioration of the emergency department. Among the problems they cited: the potentially avoidable deaths of two patients, patients without nurses, patients being left in the waiting room for hours without being reevaluated, and managements failure to follow through on its promises, according to a letter and a memo obtained by the Globe.

Last March, emergency room nurses spoke directly to Governor Maura Healey, Lieutenant Governor Kim Driscoll, and Secretary of Health and Human Services Kate Walsh about their concerns when Massachusetts officials visited Good Samaritan after a fire shut down nearby Brockton Hospital.

In September, on the day the patient died while in the registration line, 19 nurses were supposed to be on duty, according to an internal staffing report. There were eight.

Dr. Robbie Goldstein, commissioner of the state Department of Public Health, said the patients death was a tragic event and for all us it really gave us significant pause. But he said inspectors have provided close oversight of the Good Samaritan emergency department since 2021; the department thoroughly investigated every complaint, required an improvement plan, and revisited the hospital once after each plan was submitted to ensure its implementation, he told the Globe.

He acknowledged the department did not send in regular monitors until two weeks ago, but said that step has traditionally been taken only during nursing strikes.

Do I think that we will change the way that we provide oversight, evaluate facilities, and intervene at times of financial distress? Absolutely. That story is being written right now, Goldstein said.

He said he recognizes the situation at Good Samaritan and other Steward hospitals is hard for patients and Steward staff. We are working 24/7 with Steward and with the rest of health care to make sure that we can address the challenges that people are facing, he added.

The inspections of Good Samaritan were conducted by state officials on behalf of the US Centers for Medicare and Medicaid Services, which issues reports called statements of deficiencies when it finds problems. Those reports include descriptions of incidents but not patients names or other identifying details.

In a statement emailed to the Globe, Good Samaritan president Matt Hesketh said that after the immediate jeopardy findings on Sept. 26 and 28, the hospital immediately hired technicians to help assess the vital signs of patients in the waiting room, and deployed nurse practitioners and physician assistants to help triage walk-in patients steps that were part of the improvement plan. The hospital also is offering $40,000 signing bonuses to nurses hired to work in the emergency department.

Inspectors from the Centers for Medicare and Medicaid Services recently visited the hospital and we remain in full compliance with all guidelines and protocols, Hesketh said.

We have faced unprecedented challenges over the past few years, however, the safety of our patients and providing excellent, compassionate care is our focus day in and day out, he added.

Goldstein, however, said that monitors stationed at Good Samaritan and other Steward hospitals have received additional complaints about patient care, and that the department is investigating the allegations. He did not describe the nature of them.

Experts in emergency medicine and patient safety consulted by the Globe could not assess whether the issues at Good Samaritan were more severe than elsewhere.

Theres a lot of bad things there, said Dr. Joseph C. Tennyson, president of the Massachusetts College of Emergency Physicians, an advocacy group for doctors, after being told of the reports. But he added, Bad things like this are happening everywhere right now because the capacity doesnt exist.

Just two weeks ago, the state Department of Public Health designated hospitals in Greater Boston and north of the city as Tier 3, meaning they have a high risk of capacity problems throughout their hospitals and need to meet more frequently with health officials and one another to coordinate patient load. Good Samaritan and other hospitals south of Boston have been in Tier 3 for the past year, after Brockton Hospital closed.

Patients have suffered because of delays at other hospitals. A disabled patient became unresponsive in the emergency department waiting room at Cooley Dickinson Hospital in Northampton in November 2022, during a six-hour wait for care. He died several hours later.

The patient, a 74-year-old man, checked in about 8:30 p.m. complaining of a cough and other respiratory symptoms. The triage nurse ordered lab tests and a chest X-ray and sent him to the waiting room, but failed to measure his blood oxygen level, according to a state inspection report. Another nurse told inspectors the triage nurse was running behind and there were too many patients waiting to be triaged. When his guardian the man was disabled, according to a relative told staff he did not look well, they found him unresponsive. Death records show he had the flu and pneumonia, and died of sepsis.

Laura Oggeri, a spokesperson for Mass General Brigham, which owns Cooley Dickinson, said that she could not discuss a specific case due to patient confidentiality rules, but that the hospital now requires mandatory additional medical reassessments for those waiting for care.

While many emergency departments are struggling with severe overcrowding amid a national shortage of nurses, they differ in how effectively they respond, said Barbara Fain, executive director of the Betsy Lehman Center for Patient Safety, a Massachusetts state agency.

We do know that there is wide variability in the safety cultures of different hospitals, and that is really driven by the leadership, she said.

Dr. Zirui Song, associate professor of health care policy and medicine at Harvard Medical School, said the circumstances at Good Samaritan might be attributable to staffing reductions. A study he and others published in December found that after hospitals are acquired by a private equity company, they experience a 25 percent increase in adverse events, such as infections and falls. This is happening even as other hospitals are seeing a decline in such events, he said.

One of the primary hypotheses that we have is that staffing reductions after a private equity acquisition might explain these findings, Song said, and that might apply as well to the emergency department.

Song, an internist at Massachusetts General Hospital, called what happened to patients at Good Samaritan gut-wrenching and heart-breaking and not something he would expect to see at Mass. General, even when the emergency department is extremely busy. Patients with chest pain and shortness of breath are typically worked up fairly rapidly, he said.

So the fact the E.D. is full does not mean that these adverse events . . . are acceptable or expected, he said.

But sometimes they are unavoidable, said Tennyson, the emergency physicians group president. As an emergency department physician, he said, he has seen patients designated ESI 2 the second most severe level of patient illness who have waited 14 hours or longer. Ideally a patient with chest pain would be seen right away and get an electrocardiogram, a recording of the hearts electrical activity that can help diagnose a heart attack, within 10 minutes, said Tennyson, who is chief of emergency medicine at UMass Memorial HealthAlliance-Clinton Hospital.

But its not uncommon for a chest pain patient to have to wait in a busy ER, because there are five or six people or more that are having chest pain, and most of them are not having a heart attack, Tennyson said.

Those situations are painful and demoralizing for the staff, he said.

To see somebody in the waiting room that you absolutely know you need to go see, that you need to get seen right away, and theres no way to do it thats injurious and its contributing to burnout, he said.

Liz Kowalczyk can be reached at lizbeth.kowalczyk@globe.com. Felice J. Freyer can be reached at felice.freyer@globe.com. Follow her @felicejfreyer.

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Steward Health Care news: ER near Boston put patients in jeopardy - The Boston Globe

Role of AI in Neuroscience Research and Understanding of the Human Brain – Medriva

With the advent of artificial intelligence (AI), the field of neuroscience is undergoing a transformation. The sheer complexity and intricate dynamics of the human brain have been a challenge for neuroscientists. With the explosion of data, the gap between information and knowledge is becoming increasingly apparent. However, AI is starting to bridge this gap, providing profound insights into the workings of the human brain and paving the way for unprecedented discoveries.

AI is progressively becoming a potent tool in understanding the human brain, simulating the way neurons connect and fire. By mimicking the human brains structure and function, AI algorithms can simulate how the virtual brain reacts to stimuli. This offers invaluable insights into the real brains processes. AIs ability to identify subtle patterns in brain activity is instrumental in accelerating progress in neuroscience research. It is even beginning to demonstrate abilities in understanding the emotional tone in language and generating creative text formats. The application of AI in neuroscience is transforming biology into an engineering discipline, driving innovation and opening doors to unimaginable discoveries.

Publications like the BRAIN journal underscore the intersection of artificial intelligence, cognitive sciences, and neuroscience. Listed in online libraries of universities and organizations, the journal provides original contributions in these fields, emphasizing the increasing reliance of neuroscience on AI. As such, it is clear that AI tools are streamlining neuroscience research, accelerating the pace of innovation and progress in the field.

Elemind, an AI-enhanced neurotech health company, is an excellent example of how AI is revolutionizing neuroscience. With a $12M Seed round, Elemind is developing wearable neurotechnology that reads individual brainwaves and guides them in real-time. This real-time guidance changes behavior in a more targeted, smarter, and natural way than pharmaceuticals, a method which Elemind describes as electric medicine. This adaptive, drug-free approach fine-tunes stimulation based on the bodys response until the desired state is achieved. The technology, backed by five clinical trials and several peer-reviewed scientific journals, has shown effectiveness in inducing sleep, suppressing essential tremors, boosting memory, increasing pain thresholds, and enhancing sedation. Eleminds dynamic neurostimulation techniques and core signal processing algorithms are covered by three critical patents.

At Imperial College London, the Neural Reckoning Group, led by Dan Goodman, is using spiking neural networks to understand how biological and artificial brains reckon or compute. This research is another testament to the potential of AI in neuroscience, showing how AI can be used to decipher the complex computations in both biological and artificial brains.

The integration of AI in neuroscience is a testament to the potential of technological innovation in understanding and enhancing the human brain. As AI continues to evolve, its role in neuroscience will only increase, leading to groundbreaking discoveries and advancements. Whether its understanding the emotional tone in language or enhancing cognitive function, AI is positioning itself at the forefront of neuroscience research. Its not just about gathering more information; its about turning that information into knowledge and understanding, ultimately transforming biology into an engineering discipline.

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Role of AI in Neuroscience Research and Understanding of the Human Brain - Medriva

Brain’s Method for Preserving Cognition in Aging Revealed – Neuroscience News

Summary: A groundbreaking study uncovered the brains remarkable ability to compensate for age-related decline by activating additional regions to maintain cognitive performance.

This research demonstrates that older adults can indeed enhance their task performance through the brains adaptive recruitment of other areas, particularly the cuneus region, which is not typically associated with the multiple demand network (MDN) involved in fluid intelligence tasks.

By analyzing fMRI scans of 223 adults during problem-solving tasks, the study reveals a nuanced understanding of how the brain navigates the challenges of aging, potentially opening pathways to interventions that could bolster cognitive health in older populations.

This comprehensive analysis underscores the complexity of brain function and adaptation, offering hope for mitigating the effects of aging on cognitive abilities.

Key Facts:

Source: University of Cambridge

Scientists have found the strongest evidence yet that our brains can compensate for age-related deterioration by recruiting other areas to help with brain function and maintain cognitive performance.

As we age, our brain gradually atrophies, losing nerve cells and connections and this can lead to a decline in brain function. Its not fully understood why some people appear to maintain better brain function than others, and how we can protect ourselves from cognitive decline.

A widely accepted notion is that some peoples brains are able to compensate for the deterioration in brain tissue by recruiting other areas of the brain to help perform tasks. While brain imaging studies have shown that the brain does recruit other areas, until now it has not been clear whether this makes any difference to performance on a task, or whether it provides any additional information about how to perform that task.

In a study published in the journaleLife, a team led by scientists at the University of Cambridge in collaboration with the University of Sussex have shown that when the brain recruits other areas, it improves performance specifically in the brains of older people.

Study lead Dr Kamen Tsvetanov, an Alzheimers Society Dementia Research Leader Fellow in the Department of Clinical Neurosciences, University of Cambridge, said: Our ability to solve abstract problems is a sign of so-called fluid intelligence, but as we get older, this ability begins to show significant decline.

Some people manage to maintain this ability better than others. We wanted to ask why that was the case are they able to recruit other areas of the brain to overcome changes in the brain that would otherwise be detrimental?

Brain imaging studies have shown that fluid intelligence tasks engage the multiple demand network (MDN), a brain network involving regions both at the front and rear of the brain, but its activity decreases with age.

To see whether the brain compensated for this decrease in activity, the Cambridge team looked at imaging data from 223 adults between 19 and 87 years of age who had been recruited by theCambridge Centre for Ageing & Neuroscience (Cam-CAN).

The volunteers were asked to identify the odd-one-out in a series of puzzles of varying difficulty while lying in a functional magnetic resonance imaging (fMRI) scanner, so that the researchers could look at patterns of brain activity by measuring changes in blood flow.

As anticipated, in general the ability to solve the problems decreased with age. The MDN was particularly active, as were regions of the brain involved in processing visual information.

When the team analysed the images further using machine-learning, they found two areas of the brain that showed greater activity in the brains of older people, and also correlated with better performance on the task.

These areas were the cuneus, at the rear of the brain, and a region in the frontal cortex. But of the two, only activity in the cuneus region was related to performance of the task more strongly in the older than younger volunteers, and contained extra information about the task beyond the MDN.

Although it is not clear exactly why the cuneus should be recruited for this task, the researchers point out that this brain region is usually good at helping us stay focused on what we see.

Older adults often have a harder time briefly remembering information that they have just seen, like the complex puzzle pieces used in the task. The increased activity in the cuneus might reflect a change in how often older adults look at these pieces, as a strategy to make up for their poorer visual memory.

Dr Ethan Knights from the Medical Research Council Cognition and Brain Sciences Unit at Cambridge said: Now that weve seen this compensation happening, we can start to ask questions about why it happens for some older people, but not others, and in some tasks, but not others. Is there something special about these people their education or lifestyle, for example and if so, is there a way we can intervene to help others see similar benefits?

Dr Alexa Morcom from the University of Sussexs School of Psychology and Sussex Neuroscience research centre said: This new finding also hints that compensation in later life does not rely on the multiple demand network as previously assumed, but recruits areas whose function is preserved in ageing.

Funding: The research was supported by the Medical Research Council, the Biotechnology and Biological Sciences Research Council, the European Unions Horizon 2020 research and innovation programme, the Guarantors of Brain, and the Alzheimers Society.

Author: Craig Brierley Source: University of Cambridge Contact: Craig Brierley University of Cambridge Image: The image is credited to Neuroscience News

Original Research: Open access. Neural Evidence of Functional Compensation for Fluid Intelligence Decline in Healthy Ageing by Kamen Tsvetanov et al. eLife

Abstract

Neural Evidence of Functional Compensation for Fluid Intelligence Decline in Healthy Ageing

Functional compensation is a common notion in the neuroscience of healthy ageing, whereby older adults are proposed to recruit additional brain activity to compensate for reduced cognitive function. However, whether this additional brain activity in older participants actually helps their cognitive performance remains debated.

We examined brain activity and cognitive performance in a human lifespan sample (N=223) while they performed a problem-solving task (based on Cattells test of fluid intelligence) during functional magnetic resonance imaging (fMRI).

Whole-brain univariate analysis revealed that activity in bilateral cuneal cortex for hard vs. easy problems increased both with age and with performance, even when adjusting for an estimate of age-related differences in cerebrovascular reactivity.

Multivariate Bayesian decoding further demonstrated that age increased the likelihood that activation patterns in this cuneal region provided non-redundant information about the two task conditions, beyond that of the multiple-demand network generally activated in this task.

This constitutes some of the strongest evidence yet for functional compensation in healthy ageing, at least in this brain region during visual problem-solving.

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Brain's Method for Preserving Cognition in Aging Revealed - Neuroscience News

Fatty Acids in Brain Key in Memory Formation – Neuroscience News

Summary: Researchers made a breakthrough discovery on how saturated fatty acids in the brain contribute to memory consolidation. The team have mapped out the molecular processes and identified critical genes, such as PLA1 and STXBP1, that regulate the formation of these fatty acids during neuronal communication, offering new insights into potential treatments for neurodegenerative diseases.

By experimenting with mouse models, the researchers observed a direct correlation between levels of saturated fatty acids and memory function, highlighting the essential role of these compounds in cognitive health.

This work, a collaboration among several prestigious institutions, not only deepens our understanding of memory mechanisms but also opens the door to innovative therapeutic strategies for conditions like Alzheimers disease.

Key Facts:

Source: University of Queensland

Researchers at the University of Queensland have revealed the crucial role of saturated fatty acids in the brains consolidation of memories.

Dr Isaac Akefefrom UQsQueensland Brain Institutehas uncovered the molecular mechanism and identified the genes underlying the memory creation process, opening the door to a potential treatment for neurodegenerative disorders.

Weve shown previously that levels of saturated fatty acids increase in the brain during neuronal communication, but we didnt know what was causing these changes, Dr Akefe said.

Now for the first time, weve identified alterations in the brains fatty acid landscape when the neurons encode a memory.

An enzyme called Phospholipase A1 (PLA1) interacts with another protein at the synapse called STXBP1 to form saturated fatty acids.

The brain is the bodys fattiest organ, with fatty compounds called lipids making up 60% of its weight. Fatty acids are the building blocks of a class of lipids called phospholipids.

The work done inProfessor Frederic Meunierslaboratory has shown that STXBP1 controls the targeting of the PLA1 enzyme, coordinating the release of fatty acids and directing communication at the synapses in the brain.

Human mutations in the PLA1 and the STXBP1 genes reduce free fatty acid levels and promote neurological disorders, Professor Meunier said.

To determine the importance of free fatty acids in memory formation, we used mouse models where the PLA1 gene is removed.

We tracked the onset and progression of neurological and cognitive decline throughout their lives.

We saw that even before their memories became impaired, their saturated free fatty acid levels were significantly lower than control mice.

This indicates that this PLA1 enzyme, and the fatty acids it releases, play a key role in memory acquisition.

The research has important implications for understanding of how memories are formed.

Our findings indicate that manipulating this memory acquisition pathway has exciting potential as a treatment for neurodegenerative diseases, such as Alzheimers, Professor Meunier said.

The research team acknowledges the contributions of PhD candidates Saber Abd Elkader from the Australian Institute for Bioengineering and Nanotechnology, and Benjamin Matthews from the Queensland Brain Institute.

This is a collaborative study with the University of New South Wales, University of Strasbourg, University of Bordeaux, The Scripp Research Institute and the Baylor College of Medicine.

Author: Elaine Pye Source: University of Queensland Contact: Elaine Pye University of Queensland Image: The image is credited to Neuroscience News

Original Research: Open access. The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids by Fred Meunier et al. EMBO Journal

Abstract

The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids

The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brains lipid landscape remain largely unexplored.

The levels of saturated FFAs, particularly of myristic acid (C14:0), strongly increase during neuronal stimulation and memory acquisition, suggesting the involvement of phospholipase A1 (PLA1) activity in synaptic plasticity.

Here, we show that genetic ablation of the PLA1 isoform DDHD2 in mice dramatically reduces saturated FFA responses to memory acquisition across the brain.

Furthermore, DDHD2 loss also decreases memory performance in reward-based learning and spatial memory models prior to the development of neuromuscular deficits that mirror human spastic paraplegia. Via pulldown-mass spectrometry analyses, we find that DDHD2 binds to the key synaptic protein STXBP1.

Using STXBP1/2 knockout neurosecretory cells and a haploinsufficient STXBP1+/mouse model of human early infantile encephalopathy associated with intellectual disability and motor dysfunction, we show that STXBP1 controls targeting of DDHD2 to the plasma membrane and generation of saturated FFAs in the brain.

These findings suggest key roles for DDHD2 and STXBP1 in lipid metabolism andin the processes of synaptic plasticity, learning, and memory.

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Fatty Acids in Brain Key in Memory Formation - Neuroscience News

Can’t Buy Me Happiness: Joy Beyond Wealth – Neuroscience News

Summary: Many Indigenous and local communities report high levels of life satisfaction despite low monetary incomes, challenging the widely held belief that economic growth is essential for happiness.

Surveying 2,966 individuals across 19 globally diverse sites, researchers found life satisfaction scores in these communities comparable to those in affluent countries, with some even surpassing the happiness indices of wealthy Scandinavian nations. This research suggests that societal well-being does not necessarily depend on material wealth, offering valuable insights for sustainable living and human happiness.

Factors such as social support, spirituality, and a connection to nature are speculated to underpin this satisfaction, pointing to potential pathways for achieving well-being without contributing to the sustainability crisis.

Key Facts:

Source: UAB

Many Indigenous peoples and local communities around the world are leading very satisfying lives despite having very little money.

This is the conclusion of a study by the Institute of Environmental Science and Technology of the Universitat Autnoma de Barcelona (ICTA-UAB), which shows that many societies with very low monetary income have remarkably high levels of life satisfaction, comparable to those in wealthy countries.

Economic growth is often prescribed as a sure way of increasing the well-being of people in low-income countries, and global surveys in recent decades have supported this strategy by showing that people in high-income countries tend to report higher levels of life satisfaction than those in low-income countries. This strong correlation might suggest that only in rich societies can people be happy.

However, a recent study conducted by ICTA-UAB in collaboration with McGill University in Canada suggests that there may be good reasons to question whether this link is universal.

While most global polls, such as the World Happiness Report, gather thousands of responses from the citizens of industrialized societies, they tend to overlook people in small-scale societies on the fringes, where the exchange of money plays a minimal role in everyday life and livelihoods depend directly on nature.

The research, published in the scientific journalProceedings of the National Academy of Sciences(PNAS),consisted of a survey of 2,966 people from Indigenous and local communities in 19 globally distributed sites. Only 64% of surveyed households had any cash income.

The results show that surprisingly, many populations with very low monetary incomes report very high average levels of life satisfaction, with scores similar to those in wealthy countries, says Eric Galbraith, researcher at ICTA-UAB and McGill University and lead author of the study.

The average life satisfaction score across the studied small-scale societies was 6.8 on a scale of 0-10. Although not all societies reported being highly satisfied averages were as low as 5.1 four of the sites reported average scores higher than 8, typical of wealthy Scandinavian countries in other polls, and this is so, despite many of these societies having suffered histories of marginalization and oppression.

The results are consistent with the notion that human societies can support very satisfactory lives for their members without necessarily requiring high degrees of material wealth, as measured in monetary terms.

The strong correlation frequently observed between income and life satisfaction is not universal and proves that wealth as generated by industrialized economies is not fundamentally required for humans to lead happy lives, says Victoria Reyes-Garcia, ICREA researcher at ICTA-UAB and senior author of the study.

The findings are good news for sustainability and human happiness, as they provide strong evidence that resource-intensive economic growth is not required to achieve high levels of subjective well-being.

The researchers highlight that, although they now know that people in many Indigenous and local communities report high levels of life satisfaction, they do not know why.

Prior work would suggest that family and social support and relationships, spirituality, and connections to nature are among the important factors on which this happiness is based, but it is possible that the important factors differ significantly between societies or, conversely, that a small subset of factors dominate everywhere.

I would hope that, by learning more about what makes life satisfying in these diverse communities, it might help many others to lead more satisfying lives while addressing the sustainability crisis, Galbraith concludes.

Author: Octavi Lopez Source: UAB Contact: Octavi Lopez UAB Image: The image is credited to Neuroscience News

Original Research: The findings will appear in PNAS

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Can't Buy Me Happiness: Joy Beyond Wealth - Neuroscience News

The Synergistic Relationship between Human Brains and Large Language Models: A Cognitive and Social Revolution – Medriva

As we navigate the digital age, our understanding of cognitive development is evolving. One notable area of growth is the burgeoning partnership between human brains and Large Language Models (LLMs). This relationship is not just a scientific curiosity, but a pivotal cognitive and social advance thats reshaping how we think, solve problems, and innovate.

At the heart of this partnership is language. As explored in a Psychology Today article, language serves as a shared foundation between human cognition and LLMs. Its through language that these two entities collaborate, resulting in complementary capabilities that elevate collective wisdom and unlock new avenues of exploration and creativity.

But the synergy doesnt stop at language alone. A recent Science Daily report highlights a new perspective on how LLMs can be utilized by neuroscientists to interpret and analyze data. The potential for LLMs to generate insights and make clinical progress, even without a full understanding of the biological processes they discover, is profound. However, leveraging the full potential of LLMs in neuroscience demands more data processing and storage infrastructure, alongside a shift towards a more data-driven scientific approach.

The integration of LLMs into neuroscience is not just about understanding the brainits about changing the face of healthcare. As detailed in an article on Medriva, LLMs like ChatGPT are being used to analyze vast datasets, accelerating discoveries in areas such as neurodegeneration drug development. The use of AI is offering unique insights into the human brain, bridging the gap between circuits and neurons, and providing unprecedented insights into how our brains process information, learn, and make decisions. The development of a virtual brain, a digital twin of the real thing, is now possible, promising breakthroughs in research and shaping the future of healthcare.

While this synergy between human brains and LLMs holds great promise, it also raises critical ethical and privacy concerns. As discussed in a LinkedIn post, the integration of LLMs into various fields such as healthcare, education, and research necessitates careful consideration of data privacy and ethical use. As we continue to leverage LLMs for human decision-making and problem-solving, these concerns must be meticulously addressed to ensure the responsible and fair use of this powerful technology.

In conclusion, the partnership between human brains and LLMs represents a significant leap forward in cognitive and social development. Whether in enriching our collective intelligence, driving breakthroughs in neuroscience, or revolutionizing healthcare, the potential of this synergistic relationship is vast. As we continue to explore this frontier, its crucial to navigate this journey with an ethical compass, ensuring that the benefits are realized responsibly and equitably.

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The Synergistic Relationship between Human Brains and Large Language Models: A Cognitive and Social Revolution - Medriva