Freshwater resources at risk thanks to human behavior – Sunnyside Sun

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By Isobel Williams via SWNS

Earths freshwater cycle has been knocked out of its stable state by man, warns a new study.

The research shows that human pressures - such as dam construction, large-scale irrigation and global warming- have altered freshwater resources to such an extent that their capacity to regulate vital ecological and climatic processes is at risk.

The study, published in the journal Nature Water, explains that for the past century, humans have been pushing the Earths freshwater system far beyond the stable conditions that prevailed before industrialization.

The international research team, led by Aalto University in Finland, notes that this is the first time that global water cycle change has been assessed over such a long timescale with an appropriate reference baseline.

To get their results the researchers calculated monthly streamflow and soil moisture at a spatial resolution of roughly 50x50 kilometers using data from hydrological models that combine all major human impacts on the freshwater cycle.

As a baseline, they determined the conditions during the pre-industrial period (1661-1860) and compared the industrial period (1861-2005) against this baseline.

Their analysis revealed an increase in the frequency of exceptionally dry or wet conditions deviations in streamflow and soil moisture.

Overall, they saw that the global land area experiencing deviations has nearly doubled compared with pre-industrial conditions.

Vili Virkki, a doctoral researcher at Aalto University, said: We found that exceptional conditions are now much more frequent and widespread than before, clearly demonstrating how human actions have changed the state of the global freshwater cycle.

(Photo by Artem Podrez via Pexels)

In their study, the researchers were able to explore geographical differences in these deviations.

They found that exceptionally dry streamflow and soil moisture conditions became more frequent in many tropical and subtropical regions, while many boreal and temperate regions saw an increase in exceptionally wet conditions, especially in terms of soil moisture.

They also found that there were more complex patterns in many regions with a long history of human land use and agriculture.

For example, the Nile, Indus and Mississippi River basins have experienced exceptionally dry streamflow and wet soil moisture conditions, indicating changes driven by irrigation.

Dr. Miina Porkka said: Using a method thats consistent and comparable across hydrological variables and geographical scales is crucial for understanding the biophysical processes and human actions that drive the changes were seeing in freshwater.

The team hopes that their findings will better inform future research on changes in the freshwater cycle.

Associate Professor Matti Kummu added: Understanding these dynamics in greater detail could help guide policies to mitigate the resulting harm but our immediate priority should be to decrease human-driven pressures on freshwater systems, which are vital to life on Earth.

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Freshwater resources at risk thanks to human behavior - Sunnyside Sun

Astrocytes Play Critical Role in Regulating Behavior – Neuroscience News

Summary: Researchers made a groundbreaking discovery in identifying a unique group of astrocytes, located in the brains central striatum, that play a crucial role in regulating behaviors linked to neuropsychiatric disorders. This distinct subset of astrocytes expresses the gene Crym, coding for -crystallin, a protein associated with various human diseases.

By experimentally reducing Crym expression in these astrocytes, the study observed increased repetitive behaviors in mice, akin to human perseveration seen in conditions like autism and OCD. This novel finding not only challenges the neuron-centric view of brain function but also opens up new avenues for potential treatments targeting specific astrocyte populations.

Key Facts:

Source: UCLA

UCLA Health researchers have discovered a group of specialized support cells in the brain that can regulate behaviors associated with human neuropsychiatric disorders.

Thestudy, published in the journalNature, focused on a group of cells known as astrocytes star-shaped cells that tile the central nervous system and provide a support structure for the neural communication networks.

While neurons have long been understood to have primary control of behavior, the study found that a distinct group of astrocytes located deep in the central region of the brain, known as the central striatum, may also regulate communications between neurons.

Unlike other astrocytes, this group of astrocytes express the geneCrym, which encodes for the protein known as -crystallin. This protein has been associated with several human diseases including neuropsychiatric disorders, but its influence on brain function has remained largely unknown.

Several years ago the lab identified that astrocytes in the striatum expressCrym. It was my job to find out what it did. By reducing expression of this gene in astrocytes of the central striatum, I uncovered mechanisms related to a specific behavior called perseveration, saidMatthias Ollivier, the studys first author and postdoctoral scholar at theDavid Geffen School of Medicine at UCLA.

In the study, researchers genetically reduced the expression of the gene in this group of astrocytes in mice. Studying the behavior of mice, the researchers found they had significant increases in repetitive behavioral patterns or activities that serve little purpose or made it difficult for the mice to transition to other activities.

This behavior, known as perseveration, is associated with neurological and psychiatric disorders including autism, obsessive-compulsive disorder, Huntingtons disease and Tourette syndrome.

The study found thatCrym-positive astrocytes in the central striatum regulated neurotransmitter communication at synapses from the cortex to the center of the brain within the striatum.

At a basic biology level, the study provides evidence that distinct types of astrocytes have important neurobiological functions, saidBaljit Khakh, the senior author of the study and professor of physiology and neurobiology at the David Geffen School of Medicine at UCLA.

Researchers say the findings could be starting points in the development of potential therapies to alleviate perseveration in different disorders. Further research is underway to understand the interactions and signaling cascades regulated by -crystallin.

Author: Will Houston Source: UCLA Contact: Will Houston UCLA Image: The image is credited to Neuroscience News

Original Research: Open access. Crym-positive striatal astrocytes gate perseverative behaviour by Matthias Ollivier et al. Nature

Abstract

Crym-positive striatal astrocytes gate perseverative behaviour

Astrocytes are heterogeneous glial cells of the central nervous system. However, the physiological relevance of astrocyte diversity for neural circuits and behaviour remains unclear.

Here we show that a specific population of astrocytes in the central striatum expresses -crystallin (encoded byCrymin mice andCRYMin humans)that is associated with several human diseases, including neuropsychiatric disorders.

In adult mice, reducing the levels of -crystallin in striatal astrocytes through CRISPRCas9-mediated knockout ofCrymresulted in perseverative behaviours, increased fast synaptic excitation in medium spiny neurons and dysfunctional excitatoryinhibitory synaptic balance.

Increasedperseveration stemmed from the loss ofastrocyte-gated control of neurotransmitter release from presynaptic terminals of orbitofrontal cortexstriatum projections. We found that perseveration could be remedied using presynaptic inhibitory chemogenetics, and that this treatment also corrected the synaptic deficits.

Together, our findings reveal converging molecular, synaptic, circuit and behavioural mechanisms by which a molecularly defined and allocated population of striatal astrocytes gates perseveration phenotypes that accompany neuropsychiatric disorders.

Our data show thatCrym-positive striatal astrocytes have key biological functions within the central nervous system, and uncover astrocyteneuron interaction mechanisms that could be targeted in treatments for perseveration.

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Astrocytes Play Critical Role in Regulating Behavior - Neuroscience News

Freshwater resources at risk thanks to human behavior – messenger-inquirer

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Freshwater resources at risk thanks to human behavior - messenger-inquirer

Unlocking the Power of Influenza Vaccines for Pediatric Population: A Narrative Review – Cureus

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Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional. Infectious Disease Integrative/Complementary Medicine Internal Medicine Internal Medicine-Pediatrics Medical Education and Simulation Medical Physics Medical Student Nephrology Neurological Surgery Neurology Nuclear Medicine Nutrition Obstetrics and Gynecology Occupational Health Oncology Ophthalmology Optometry Oral Medicine Orthopaedics Osteopathic Medicine Otolaryngology Pain Management Palliative Care Pathology Pediatrics Pediatric Surgery Physical Medicine and Rehabilitation Plastic Surgery Podiatry Preventive Medicine Psychiatry Psychology Pulmonology Radiation Oncology Radiology Rheumatology Substance Use and Addiction Surgery Therapeutics Trauma Urology Miscellaneous

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Unlocking the Power of Influenza Vaccines for Pediatric Population: A Narrative Review - Cureus

The role of the pediatrician in school-based mental health services – Contemporary Pediatrics

Navigating school-based mental health services can be difficult for a child with mental health issues, their family, and at times, for the pediatrician.

James Wallace, MD, associate professor, Department of Psychiatry and Pediatrics, University of Rochester Medical Center, Child and Adolescent Psychiatry Faculty Trainer,The REACH Institute, explained how to traverse the crossover landscape between the pediatrician and school, in this Q+A interview with Contemporary Pediatrics.

Contemporary Pediatrics:

What is the pediatricians role when it comes school-based mental health services?

James Wallace, MD:

The single most important thing pediatricians can do is to consider the school as a natural and important ally and partner for managing pediatric behavioral health issues. Collaboration can help us make more accurate diagnoses, develop more effective multimodal treatment plans, and monitor progress in many areas. Without collaboration and communication, there are always missing pieces.

Contemporary Pediatrics:

How can schools and pediatricians work better together, or what are the missing links?

Wallace:

Medicine and education have different ways to think about children and teens. Each uses different language, follows different laws and regulations, and uses different strategies to intervene. Therefore, collaboration requires that both parties work hard to understand each other.

Simple routine communication procedures like sending the pediatrician a copy of every Individualized Education Plan (IEP) and 504 Accommodation Plan can help. Pediatric offices could develop a liaison for schools, [such as] clerical, medical assistant, nurse, and schools could develop a liaison for medical offices, [such as] clerical, teacher on special assignment, school nurse, counselor, or administrator.

To follow confidentiality laws (HIPPA, FERPA), having convenient releases of information (ROI) and making routine communication an expectation are huge steps in the right direction.1

Contemporary Pediatrics:

When is a good time to refer a patient to a mental health professional, perhaps going from a school therapist or counselor to something more?

Wallace:

When children and teens need evidence-based care that the school cannot provide, referring to community resources for that care is critical. Both schools and PCPs should keep a list of providers in the community with whom they have had good experiences and share that resource list.

Many states have Child Psychiatric Access Programs2 where primary care providers can call to get a list of appropriate referrals. But it is not an either/or. Students often continue with their school-based counseling as they enter community-based services. Collaboration between these 2 providers using the same language and skill-building can boost the impact of interventions and help generalize changes to more settings.

Contemporary Pediatrics:

What are schools and pediatricians lacking when it comes to providing resources to children with mental health concerns?

Wallace:

A school and pediatrician team can effectively assess and manage many, perhaps most, mental health concerns in children and teens, especially if the pediatric provider had intensive training in the assessment and management of mental health problems like the Patient-centered Mental Health in Pediatric Primary Care (PPP4) course offered through the REACH Institute.3

Primary care providers can also learn time-limited evidence-based Cognitive Behavior Therapy, Parent Training and Trauma interventions that they can provide themselves for milder cases or for when access to community therapy resources is delayed or unavailable.

Children with complex symptoms and impairment often need services and expertise beyond this core team. They often need a more specialized clinical therapist in the community. Some need consultation and treatment with a child and adolescent psychiatrist or psychiatric nurse practitioner.

Others need care management, in-home services, crisis services and acute care services beyond the resources of schools and primary care providers. These services are in addition to the school-pediatrician team, not instead of.

As the complexity and impairment expands, the village of collaborating providers needed to support the family and child should grow to meet the need. Call Access Programs can be a great resource for primary care providers to learn how to use the complex and often unique network of available local services.2

Contemporary Pediatrics:

Who are the students who are most vulnerable to mental health issues?

Wallace:

Children and teens who have suffered significant trauma are a very vulnerable group who are often in need of mental health service. Behavioral health problems have genetic and environmental components (nature and nurture), so they tend to run in families, especially when the whole family is struggling.

Those who have experienced adverse childhood events (ACES) are at risk, as are children who have been bullied, who are engaged in substance use, or who are in the LBGQT+ community. Non-English speakers, recent immigrants, people of color and other minority groups are at risk due to chronic stressors. They also face complex barriers to adequate health and mental health services, so they suffer doubly with greater needs and worse access.

Contemporary Pediatrics:

What signs should pediatricians and teachers/counselors look for in these patient populations?

Wallace:

Abrupt changes in mood, behavior, academic performance and/or relationships are worrisome signs. School refusal, self-injury or suicidal comments or behaviors, verbal or physical threats or aggression are red flags.

Subtle changes can signal a possible behavioral health problem early when the problems and impairment are milder and more amenable to change. School personnel and primary care providers have the advantage of knowing their students/patients over time so they can tell when a childs behavior changes. Familiar faces make it easier for students/patients and their families to disclose their concerns and seek help.

In medical settings, the United States Preventative Services Task Force (USPSTF) recommends universal screening for high frequency mental health problems like anxiety, depression, and suicidalityavailable on the ProjectTeachNY.org websitebecause some patients and families dont disclose their concerns unless asked.1,4

Some school districts have screening protocols for the same reason. We must all be on the lookout for significant changes in mood, anxiety, aggression, relationships, and academic performance so we can help these students/patients and all children and teens get the help they need.

References:

1. Families thrive with good mental health. Project Teach. Accessed February 9, 2024. https://projectteachny.org/

2. Integrating physical and behavioral health care for every child. National Network of Child Psychiatry Access Programs. Accessed February 9, 2024. https://www.nncpap.org/

3. REACH mental health training. The REACH Institute. Accessed February 28, 2024. https://thereachinstitute.org/training/#patient-centered-mental-health-in-pediatric-primary-care-ppp

4. Mental health conditions and substance abuse. US Preventive Services Task Force. Accessed February 9, 2024. https://www.uspreventiveservicestaskforce.org/uspstf/topic_search_results?category%5B%5D=20&searchterm=

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The role of the pediatrician in school-based mental health services - Contemporary Pediatrics

Human Papillomavirus Vaccines – Immunizations – American Academy of Pediatrics

Take an 11-minute break and view this Red Book Webinar that offers strategies and resources to increase the uptake of HPV vaccines and other recommended adolescent immunizations. Presenter Janet Siddiqui, MD, MBA, FAAP, ABIHM, also shares tips to help adolescents catch up with vaccines they may have missed due to the pandemic and reviews vaccine recommendations, coverage rates and barriers to vaccination.

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Human Papillomavirus Vaccines - Immunizations - American Academy of Pediatrics

PCORI Awards CYSHCNet Researchers $5.5 Million to Study Transitions for Children and Caregivers from Hospital-to … – UNC Health and UNC School of…

Neal dejong, MD, MPH, at the UNC School of Medicine, David Y. Ming, MD, at Duke University School of Medicine and Ryan Coller, MD, at University of Wisconsin School of Medicine and Public Health, received $5.5 million to study hospital-to-home transitions across settings for children and youth with special healthcare needs.

Nearly one in five children, almost 14 million in the United States, have a special healthcare need that may require hospitalization. After a childs hospital stay, the transition back home can be risky, particularly for children with chronic health issues and complex medical conditions. To understand how to best support children and youth with special healthcare needs (CYSHCN), researchers of the CYSHCN National Research Network (CYSHCNet) received $5.5 million for a multi-site studyfunded by the Patient-Centered Outcomes Research Institute (PCORI)to compare two types of hospital-to-home transitional care to optimize outcomes.

The CYSHCNet researchers are led by David Y. Ming, MD, principal investigator, associate professor of pediatrics at Duke University School of Medicine; Neal dejong, MD, MPH, associate professor of pediatrics and member of the UNC Childrens Research Institute at the UNC School of Medicine; and Ryan Coller, MD, associate professor of pediatrics at the University of Wisconsin School of Medicine and Public Health.

Over a one-month post-discharge period, researchers will compare the effectiveness of two transitional care approaches focused doseversusextended dose reducing return visits to the hospital or emergency department and increasing parent-reported confidence. They will also evaluate the impact of each type of hospital-to-home transitional care on specific CYSHCN patient groups, including those with highly complex clinical needs and those from racial/ethnic minority groups or living in rural areas. Lastly, researchers will investigate how and why each approach to hospital-to-home transitional care is effective and for whom they work best.

The study team includes multiple community partners, including parents and caregivers with lived experience, clinicians, policymakers, and health system leaders. A community advisory board, primarily composed of a diverse group of parents/caregivers of CYSHCN, will work closely with the research team throughout the study. This collaborative effort aims to contribute to the equitable improvement of overall care for all CYSHCN transitioning from hospital to home.

About CYSHCNet:

CYSHCNet brings academic researchers and lived experience partners together to study the health care system issues that matter most to CYSHCN and their families. We help CYSHCN and their families by advancing knowledge and implementation of optimal health systems through innovative, rigorous multi-site studies, far reaching dissemination of findings, meaningful partnerships with families, and strong training of emerging CYSHCN investigators. Learn more:https://cyshcnet.org/.

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PCORI Awards CYSHCNet Researchers $5.5 Million to Study Transitions for Children and Caregivers from Hospital-to ... - UNC Health and UNC School of...

Reminder for IPRC Webinar Preventing Secondary Trauma and Practical Self Care for Pediatric Rehabilitation … – RCPA

Monday, March 4, 2024 12:00 pm 1:00 pm EST; 11:00 am 12:00 pm CST; 10:00 am 11:00 am MST; 9:00 am 10:00 am PST Register Here

Kara Monnin, PhD Kara Monnin, PhD, is a Clinical Assistant Professor of Pediatrics at Nationwide Childrens Hospital and Ohio State Universitys School of Medicine in Columbus, OH. Dr. Monnin provides clinical services across multiple inpatient units, including complex healthcare, inpatient physical medicine and rehabilitation, and acute care services (PICU, Trauma/Surgery/Neurosurgery), and operates on a consultative basis for Complex Care clinics. Dr. Monnin also serves as a member of the Advanced Illness Management/Palliative Care team at NCH and specializes in traumatic brain injury, rehabilitation populations, and children and adolescents with complex medical needs.

Kelsey E. Bakaletz, MSW, LISW Kelsey E. Bakaletz, MSW, LISW, is most importantly, a mother to 2-year-old Ellis. Kelsey is a clinical medical social worker in Developmental Behavioral Pediatrics at Nationwide Childrens Hospital in Columbus, OH. Kelsey received both undergraduate and graduate degrees from Ohio State University. Prior to working at NCH, Kelsey spent two years in rapid re-housing of homeless military veterans, and before that, she spent almost two years in therapeutic rehabilitation of adjudicated juvenile sex offenders. Kelsey is a member of the Trauma-Informed Care Work Group at Nationwide Childrens Hospital, working to provide and teach the best trauma-informed practices. Kelsey is passionate about treating every patient interaction as though the caregiver and child are part of our family, to lead with empathy, compassion, and determination that we resist re-traumatization.

Objectives: At the end of this session, the learner will:

Audience: This webinar is intended for all members of the rehabilitation team, including medical staff, nurses, physical therapists, occupational therapists, speech language pathologists, licensed psychologists, mental health professionals, and other interested professionals.

Level: Intermediate

Certificate of Attendance: Certificates of attendance are available for all attendees. No CEs are provided for this course.

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Reminder for IPRC Webinar Preventing Secondary Trauma and Practical Self Care for Pediatric Rehabilitation ... - RCPA