Hardwiring Your Brain: The Neuroscience Of Behaviour Change | TheHealthSite.com – TheHealthSite

Children Care World Down Syndrome Day: What Kind Of Dietary, Fitness Parameters Should Kids With Down Syndrome Have?

In December 2011, the UN General Assembly declared March 21 as 'World Down Syndrome Day'. Around the world, there is a need for more societal acceptance for people born with this disorder, so that they are rewarded with inclusivity, proper healthcare, career opportunities and everything else needed to live a regular life.

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Hardwiring Your Brain: The Neuroscience Of Behaviour Change | TheHealthSite.com - TheHealthSite

Neuroscience and Society Series: Aligning Science with the Public’s Values – The Hastings Center

Hastings Center News Published March 22, 2024March 22, 2024Posted in Neuroscience

Research that involves implanting devices into the brains of human volunteers creates a special moral obligation that extends beyond the trial periodan obligation that researchers, device manufacturers, and funders owe to the volunteers. This is the conclusion of two new essays in the Hastings Center Report that launch a series on the ethical and social issues raised by brain research.

The Neuroscience and Society series is supported by the Dana Foundation and will be published in open-access format online over the next three years.

The series seeks to promote deliberative public engagement about neuroscience, writes Hastings Center senior research scholar Gregory E. Kaebnick, who leads the development of the series, in Neuroscience and Society: Supporting and Unsettling Public Engagement, the introductory essay. The ultimate goal of the Neuroscience and Society series is to contribute to a vitally important but somewhat uncertain political project often called alignment. The guiding thought in that project is that science should align with the publics values; it should take society in a direction thats good for society, as judged by society.

Following the introduction, two essays discuss post-trial ethical obligations raised by studies with cutting-edge neural devices that have a range of potential benefits, such as deep brain stimulation to alleviate psychiatric conditions and brain-computer interfaces to aid communication.

Brain Pioneers and Moral Entanglement: An Argument for Post-trial Responsibilities in Neural-Device Trials Sara Goering, Andrew I. Brown, and Eran Klein

Human participants in neural-device trials are brain pioneers, entrusting researchers with access to their brains. For many of these researchers, what should happen at the end of the study is a troubling question without a clear answer. Researchers and funders of neural-device trials owe something to participants that, we insist, exceeds the usual benefits of participating, write the authors. In many cases, it includes ensuring participants continued access to neural devices.

Identity Theft, Deep Brain Stimulation, and the Primacy of Post-trial Obligations Joseph J. Fins, Amanda R. Merner, Megan S. Wright, and Gabriel Lzaro-Muoz

When neuroethicists write about deep brain stimulation (DBS) via implanted neural devices, they sometimes resort to science fiction hyperboleimagining parables of cyborgs whose identities are hijacked by the technology, the essay begins. This is because with the implantation of such technology comes the threat of a loss of personal identity, that sense of self that is felt as unique to a person. But findings from two deep brain stimulation trials for traumatic brain injury and obsessive-compulsive disorder reveal that injury and illness rob individuals of personal identity and that neuromodulation can restore it. The early success of these interventions makes a compelling case for continued post-trial access to these technologies.

The series is developed with support from Hastings Center senior research scholar Erik Parens. and the guidance of a steering committee of six scholars:

Jennifer Chandler, University of Ottawa Winston Chiong, University of California San Francisco Joseph J. Fins, Weill Cornell Medical School Sara Goering, University of Washington Jonathan D. Moreno, University of Pennsylvania Oliver Rollins, University of Washington

Learn more about the series here.

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Neuroscience and Society Series: Aligning Science with the Public's Values - The Hastings Center

Study Links Diet, Diabetes, and Alzheimers – Neuroscience News

Summary: A new study explores the molecular connections between Type 2 diabetes and Alzheimers, supporting the notion of Alzheimers as Type 3 diabetes.

This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimers-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimers risk.

The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.

Key Facts:

Source: ASBMB

New research conducted in mice offers insights into whats going on at the molecular level that could cause people with diabetes to develop Alzheimers disease.

The study adds to a growing body of research on the links between Type 2 diabetes and Alzheimers disease, which some scientists have called Type 3 diabetes.

The findings suggest that it should be possible to reduce the risk of Alzheimers by keeping diabetes well controlled or avoiding it in the first place, according to researchers.

NarendraKumar, an associate professor at Texas A&M University in College Station, led the study.

We think that diabetes and Alzheimers disease are strongly linked, Kumar said, and by taking preventative or amelioration measures for diabetes, we can prevent or at least significantly slow down the progression of the symptoms of dementia in Alzheimers disease.

Kumar will present the new research atDiscover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, which is being held March 2326 in San Antonio.

Diabetes and Alzheimers are two of the fastest-growing health concerns worldwide. Diabetes alters the bodys ability to turn food into energy and affects an estimated 1 in 10 U.S. adults. Alzheimers, a form of dementia that causes progressive decline in memory and thinking skills, is among the top 10 leading causes of death in the United States.

Diet is known to influence the development of diabetes as well as the severity of its health impacts. To find out how diet could influence the development of Alzheimers in people with diabetes, the researchers traced how a particular protein in the gut influences the brain.

They found that a high-fat diet suppresses the expression of the protein, called Jak3, and that mice without this protein experienced a cascade of inflammation starting with the intestine, moving through the liver and on to the brain.

Ultimately, the mice showed signs of Alzheimers-like symptoms in the brain, including an overexpressed mouse beta-amyloid and hyperphosphorylated tau, as well as evidence of cognitive impairment.

Liver being the metabolizer for everything we eat, we think that the path from gut to the brain goes through liver, Kumar said.

His lab has been studying functions of Jak3 for a long time, he added, and they now know that the impact of food on the changes in the expression of Jak3 leads to leaky gut. This in turn results in low-grade chronic inflammation, diabetes, decreased ability of the brain to clear its toxic substances and dementia-like symptoms seen in Alzheimers disease.

The good news, according to Kumar, is that it may be possible to stop this inflammatory pathway by eating a healthy diet and getting blood sugar under control as early as possible.

In particular, people with prediabetes which includes an estimated 98 million U.S. adults could benefit from adopting lifestyle changes to reverse prediabetes, prevent the progression to Type 2 diabetes and potentially reduce the risk of Alzheimers.

Author: Anne Johnson Source: ASBMB Contact: Anne Johnson ASBMB Image: The image is credited to Neuroscience News

Original Research: The findings will be presented at Discover BMB

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Study Links Diet, Diabetes, and Alzheimers - Neuroscience News

AI learned how to sway humans by watching a cooperative cooking game – Science News Magazine

If youve ever cooked a complex meal with someone, you know the level of coordination required. Someone dices this, someone sauts that, as you dance around holding knives and hot pans. Meanwhile, you might wordlessly nudge each other, placing ingredients or implements within the others reach when youd like something done.

How might a robot handle this type of interaction?

Research presented in late 2023 at the Neural Information Processing Systems, or NeurIPS, conference, in New Orleans, offers some clues. It found that in a simple virtual kitchen, AI can learn how to influence a human collaborator just by watching humans work together.

In the future, humans will increasingly collaborate with artificial intelligence, both online and in the physical world. And sometimes well want an AI to silently guide our choices and strategies, like a good teammate who knows our weaknesses. The paper addresses a crucial and pertinent problem, how AI can learn to influence people, says Stefanos Nikolaidis, who directs the Interactive and Collaborative Autonomous Robotic Systems (ICAROS)lab at the University of Southern California in Los Angeles, and was not involved in the work.

The new work introduces a way for AI to learn to collaborate with humans, without even practicing with us. It could help us improve human-AI interactions, Nikolaidis says, and detect when AI might take advantage of us whether humans have programmed it to do so, or, someday, it decides to do so on its own.

There are a few ways researchers have already trained AI to influence people. Many approaches involve whats called reinforcement learning (RL), in which an AI interacts with an environment which can include other AIs or humans and is rewarded for making sequences of decisions that lead to desired outcomes. DeepMinds program AlphaGo, for example, learned the board game Go using RL.

But training a clueless AI from scratch to interact with people through sheer trial-and-error can waste a lot of human hours, and can even presents risks if there are, say, knives involved (as there might be in a real kitchen). Another option is to train one AI to model human behavior, then use that as a tireless human substitute for another AI to learn to interact with. Researchers have used this method in, for example, a simple game that involved entrusting a partner with monetary units. But realistically replicating human behavior in more complex scenarios, such as a kitchen, can be difficult.

The new research, from a group at the University of California, Berkeley, used whats called offline reinforcement learning. Offline RL is a method for developing strategies by analyzing previously documented behavior rather than through real-time interaction. Previously, offline RL had been used mostly to help virtual robots move or to help AIs solve mazes, but here it was applied to the tricky problem of influencing human collaborators. Instead of learning by interacting with people, this AI learned by watching human interactions.

Humans already have a modicum of competence at collaboration. So the amount of data needed to demonstrate competent collaboration when two people are working together is not as much as would be needed if one person were interacting with an AI that had never interacted with anyone before.

In the study, the UC Berkeley researchers used a video game called Overcooked, where two chefs divvy up tasks to prepare and serve meals, in this case soup, which earns them points. Its a 2-D world, seen from above, filled with onions, tomatoes, dishes and a stove with pots. At each time step, each virtual chef can stand still, interact with whatever is in front of it, or move up, down, left or right.

The researchers first collected data from pairs of people playing the game. Then they trained AIs using offline RL or one of three other methods for comparison. (In all methods, the AIs were built on a neural network, a software architecture intended to roughly mimic how the brain works.) In one method, the AI just imitated the humans. In another, it imitated the best human performances. The third method ignored the human data and had AIs practice with each other. And the fourth was the offline RL, in which AI does more than just imitate; it pieces together the best bits of what it sees, allowing it to perform better than the behavior it observes. It uses a kind of counterfactual reasoning, where it predicts what score it would have gotten if it had followed different paths in certain situations, then adapts.

The AIs played two versions of the game. In the human-deliver version, the team earned double points if the soup was delivered by the human partner. In the tomato-bonus version, soup with tomato and no onion earned double points. After the training, the chefbots played with real people. The scoring system was different during training and evaluation than when the initial human data were collected, so the AIs had to extract general principles to score higher. Crucially, during evaluation, humans didnt know these rules, like no onion, so the AIs had to nudge them.

On the human-deliver game, training using offline RL led to an average score of 220, about 50 percent more points than the best comparison methods. On the tomato-bonus game, it led to an average score of 165, or about double the points. To support the hypothesis that the AI had learned to influence people, the paper described how when the bot wanted the human to deliver the soup, it would place a dish on the counter near the human. In the human-human data, the researchers found no instances of one person passing a plate to another in this fashion. But there were events where someone put down a dish and ones where someone picked up a dish, and the AI could have seen value in stitching these acts together.

The researchers also developed a method for the AI to infer and then influence humans underlying strategies in cooking steps, not just their immediate actions. In real life, if you know that your cooking partner is slow to peel carrots, you might jump on that role each time until your partner stops going for the carrots. A modification to the neural network to consider not only the current game state but also a history of their partners actions would give a clue as to what their partners current strategy is.

Again, the team collected human-human data. Then they trained AIs using this offline RL network architecture or the previous offline RL one. When tested with human partners, inferring the partners strategy improved scores by roughly 50 percent on average. In the tomato-bonus game, for example, the bot learned to repeatedly block the onions until people eventually left them alone. That the AI worked so well with humans was surprising, says study coauthor Joey Hong, a computer scientist at UC Berkeley.

Avoiding the use of a human model is great, says Rohan Paleja, a computer scientist at MIT Lincoln Laboratory in Lexington, Mass., who was not involved in the work. It makes this approach applicable to a lot of real-world problems that do not currently have accurate simulated humans. He also said the system is data-efficient; it achieved its abilities after watching only 20 human-human games (each 1,200 steps long).

Nikolaidis sees potential for the method to enhance AI-human collaboration. But he wishes that the authors had better documented the observed behaviors in the training data and exactly how the new method changed peoples behaviors to improve scores.

In the future, we may be working with AI partners in kitchens, warehouses, operating rooms, battlefields and purely digital domains like writing, research and travel planning. (We already use AI tools for some of these tasks.) This type of approach could be helpful in supporting people to reach their goals when they dont know the best way to do this, says Emma Brunskill, a computer scientist at Stanford University who was not involved in the work. She proposes that an AI could observe data from fitness apps and learn to better nudge people to meet New Years exercise resolutions through notifications (SN: 3/8/17). The method might also learn to get people to increase charitable donations, Hong says.

On the other hand, AI influence has a darker side. Online recommender systems can, for example,try to have us buy more, or watch more TV, Brunskill says, not just for this moment, but also to shape us into being people who buy more or watch more.

Previous work, which was not about human-AI collaboration, has shown how RL can help recommender systems manipulate users preferences so that those preferences would be more predictable and satisfiable, even if people didnt want their preferences shifted. And even if AI means to help, it may do so in ways we dont like, according to Micah Carroll, a computer scientist at UC Berkeley who works with one of the paper authors. For instance, the strategy of blocking a co-chefs path could be seen as a form of coercion. We, as a field, have yet to integrate ways for a person to communicate to a system whattypes of influence they are OK with, he says. For example, Im OK with an AI trying to argue for a specific strategy, but not forcing me to do it if I dont want to.

Hong is currently looking to use his approach to improve chatbots (SN: 2/1/24). The large language models behind interfaces such as ChatGPT typically arent trained to carry out multi-turn conversations. A lot of times when you ask a GPT to do something, it gives you a best guess of what it thinks you want, he says. It wont ask for clarification to understand your true intent and make its answers more personalized.

Learning to influence and help people in a conversation seems like a realistic near-term application. Overcooked, he says, with its two dimensions and limited menu, is not really going to help us make better chefs.

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Rimjhim Agarwal selected as Major Symposium speaker at the American Association of Immunologists … – La Jolla Institute for Immunology

Rimjhim Agarwal, a UC San Diego Graduate Student and member of LJIs Weiskopf Lab (Image credit: La Jolla Institute for Immunology)

LA JOLLA, CALa Jolla Institute for Immunology (LJI) is pleased to announce the selection of Rimjhim Agarwal, 2024 Tullie and Rickey Families SPARK Awards for Innovations in Immunology (SPARK) winner, as a Major Symposium speaker for the American Association of Immunologists (AAI) IMMUNOLOGY2024 meeting. Agarwal joins 15 additional AAI trainee membersgraduate students and postdoctoral fellowswho were selected from 1,500 abstract submissions.

Agarwal, a UC San Diego Graduate Student and member of LJIs Weiskopf Lab, will present her research on how chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans. Chikungunya virus disease is transmitted by mosquitoes in tropical regions of Africa, Asia, and the Americas. The disease can be fatal, and many survivors are left with chronic, debilitating joint problems.

Almost 25 percent of infected individuals, predominantly women, develop chronic, arthritis-like symptoms, such as joint pain and swelling, said Agarwal in a recent LJI video interview. We dont know the cause of these symptoms, and we dont know why this happens primarily in women.

Agarwal recently won funding from The Rosemary Kraemer Raitt Foundation Trust through LJIs Tullie and Rickey Families SPARK Awards for Innovations in Immunology program to investigate these puzzling symptoms.

Rimjhim Agarwal on what we can learn from studying chikungunya virusand how her research may advance global health. (Filmed by LJI Creative Producer Matthew Ellenbogen)

This year marks the first time AAI has featured trainees in its annual conference Major Symposia. Agarwals talk will be part of the Immune Responses to Chronic Viral, Bacterial, Fungal, and Parasitic Infections Major Symposium, held on May 6. Agarwal will be joined by five faculty-level speakers and one other trainee-level speaker. She will also share her chikungunya virus research in a Poster Session.

AAIs annual meeting features the latest research from some of the brightest minds in the field of immunology, said Loretta Doan, CEO of The American Association of Immunologists. AAI trainee members are making exciting discoveries every day, and we are thrilled to offer this high-profile honor for some of them to share their work with the community.

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The La Jolla Institute for Immunology is dedicated to understanding the intricacies and power of the immune system so that we may apply that knowledge to promote human health and prevent a wide range of diseases. Since its founding in 1988 as an independent, nonprofit research organization, the Institute has made numerous advances leading toward its goal: life without disease. Visit lji.org for more information.

The American Association of Immunologists (AAI) is one of the worlds largest organizations of immunologists and scientists in related disciplines. Our mission is to improve global health and well-being by advancing immunology and elevating public understanding about the immune system. AAI members are responsible for some of the most significant biomedical discoveries of the past century, including the development of life-saving cancer immunotherapies, monoclonal antibodies, transplant technologies, and vaccines. We support scientists across the field of immunology through knowledge dissemination, community building, advocacy, and public outreach.

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Seeking new horizons: Where innovators find opportunities in a fast-changing immunology landscape – IQVIA

Unmet need is high in a long list of largely neglected immunological diseases, such as systemic lupus erythematosus, hidradenitis suppurativa, alopecia areata, Sjgren's syndrome, vitiligo, bullous pemphigoid or prurigo nodularis. Their prevalence spans a range from rare diseases with fewer than 200 thousand patients in the US, for example, to relatively more common conditions with a million or more patients, a subset of whom are severe cases most in need of innovative therapies. What they share is having been underserved, with typically limited disease-specific treatment options available to date, leaving many patients with poorly controlled disease. This represents an attractive opportunity for innovators to set an effective, new standard of care.

However, the natural history of these diseases is often less well understood and has led to several setbacks, e.g., in lupus. Nevertheless, innovators are clearly not disheartened, judging by recent pipeline momentum. For example, hidradenitis suppurativa has seen a major inflection point in development activity after many years of an innovation drought and was a key focus at the recent annual meeting of the American Academy of Dermatology (AAD), with several high-profile presentations of mid- to late-stage readouts, including AbbVies IL-1/1 antagonist lutikizumab, Novartis oral BTK inhibitor remibrutinib, and Moonlakes anti-IL-17 nanobody solenokimab.

The overall change in innovation intensity that we are witnessing across underserved immunology diseases is reminiscent of the momentum that transformed todays major autoimmune indications about 10-15 years ago. However, without such epidemiological scale, innovators today must play across multiple of those smaller indications to achieve critical mass in an immunology franchise, e.g., via a portfolio of assets and/or multi-indication assets.

Finding success in less explored immunology indications requires a different approach. Unlike the major, well-established autoimmune conditions such as RA, psoriasis or Crohns disease, smaller indications face unique challenges, for example, often low disease awareness among patients and HCPs, a limited understanding of the burden of illness and its true impact on patients life, immature care pathways, including diagnosis, specialist referral and treatment, leading to under-diagnosis and under-treatment, or convincing payers of the need to treat and for them to cover novel therapies.

Innovators targeting smaller, oft neglected immunology indications therefore must focus on three priorities:

As innovators re-direct their efforts towards historically underserved immunological diseases, long-suffering patients will be the ultimate winners, as the prospect of effective treatment options makes big strides towards becoming reality.

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Seeking new horizons: Where innovators find opportunities in a fast-changing immunology landscape - IQVIA

Researchers identify new way to inhibit immune cells that drive allergic asthma – EurekAlert

image:

Activation of ILC2s causes inflammation in mouse lungs (left), but this is reduced by treatment with Yoda1 to stimulate Piezo1 channels (right).

Credit: 2024 Hurrell et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20231835

Researchers at the Keck School of Medicine, University of Southern California, have discovered that a protein called Piezo1 prevents a type of immune cell in the lung from becoming hyperactivated by allergens. The study, to be published March 26 in the Journal of Experimental Medicine (JEM), suggests that switching on Piezo1 could represent a new therapeutic approach to reducing lung inflammation and treating allergic asthma.

Type 2 innate lymphoid cells (also known as ILC2s) are a type of immune cell that resides in the lungs, skin, and other tissues of the body. ILC2s in the lungs become activated in the presence of allergens and produce proinflammatory signals that drive the recruitment of other immune cells into the lungs. Unchecked, this can result in excessive inflammation and a tightening of the airways, making it difficult for asthma patients to properly breathe.

Given the importance of ILC2s in allergic asthma, there is an urgent need to develop novel mechanism-based approaches to target these critical drivers of inflammation in the lungs, says Omid Akbari, Professor of Immunology and Professor of Medicine at USCs Keck School of Medicine.

Akbari and colleagues discovered that, when they are activated by an allergen, ILC2s start to produce a protein called Piezo1 that can limit their activity. Piezo1 forms channels in the outer membranes of cells that open in response to mechanical changes in the cells environment, allowing calcium to enter the cell and change its activity.

Akbaris team found that, in the absence of Piezo1, mouse ILC2s became more active than normal in response to allergenic signals, and the animals developed increased airway inflammation. In contrast, treatment with a drug called Yoda1 that switches on Piezo1 channels reduced the activity of ILC2s, decreased airway inflammation, and alleviated the symptoms of allergen-exposed mice. The groups observations suggest a significant role for Piezo1 channels in ILC2 metabolism, as treatment with Yoda1 reduced ILC2 mitochondrial function and rewired the cells energy source.

Finally, the researchers determined that human ILC2s also produce Piezo1, and so they tested the effects of Yoda1 on mice whose ILC2s had been replaced with human immune cells.

Remarkably, treatment of these humanized mice with Yoda1 reduced airway hyperreactivity and lung inflammation, suggesting that Yoda1 may be used as a therapeutic tool to modulate ILC2 function and alleviate the symptoms associated with ILC2-dependent airway inflammation in humans, Akbari says. Future studies are therefore warranted to delineate the role of Piezo1 channels in human patients with asthma and develop Piezo1-driven therapeutics for the treatment of allergic asthma pathogenesis.

Hurrell et al. 2024. J. Exp. Med. https://rupress.org/jem/article-lookup/doi/10.1084/jem.20231835?PR

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About Journal of Experimental Medicine

Journal of Experimental Medicine (JEM) publishes peer-reviewed research on immunology, cancer biology, stem cell biology, microbial pathogenesis, vascular biology, and neurobiology. All editorial decisions on research manuscripts are made through collaborative consultation between professional scientific editors and the academic editorial board. Established in 1896, JEM is published by Rockefeller University Press, a department of The Rockefeller University in New York. For more information, visit jem.org.

Visit our Newsroom, and sign up for a weekly preview of articles to be published. Embargoed media alerts are for journalists only.

Follow JEM on Twitter at @JExpMed and @RockUPress.

Journal of Experimental Medicine

Experimental study

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Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity

26-Mar-2024

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Measles outbreaks show the risk of under-vaccination | News | Harvard T.H. Chan School of Public Health – HSPH News

March 27, 2024On March 18, the Centers for Disease Control and Prevention issued a health alert warning clinicians and public health officials of a global rise in measles cases. Yonatan Grad, professor of immunology and infectious diseases at Harvard T.H. Chan School of Public Health, discusses the highly transmissible disease and what may be driving its resurgence.

Q: What should the public know about measles?

A: The first thing that people should know is that measles is preventable. The measles vaccine is one of our best. One dose is 93% effective and two doses are 97% effective in protecting against infection.

Second, measles is extremely contagiousone of the most contagious pathogens we know of. In a classroom of children who are not protected against measles, a child with measles will infect 12-18 others.

Third, measles can lead to severe health consequences. About 1 in 5 unvaccinated people with measles are hospitalized. About 1 in 20 get pneumonia. About 1 in 1000 get encephalitisinflammation of the brainwhich can result in intellectual disabilities. And about 1 to 3 in 1000 die, most often from measles pneumonia.

Another thing thats not well appreciated is that measles can cause immune amnesia, in that it resets immunity to other diseases. When the vaccine was rolled out, there was not only a decline in measles, but also declines in other childhood infections like chickenpox. Recent work showed how measles infection depletes your antibodies, making you more susceptible to pathogens you had developed protection against. So the benefit of measles vaccination is two-fold: It protects people from measles and helps maintain protection against other childhood illnesses.

Q: Across the U.S. and around the world, were seeing measles cases rise. What might be driving this resurgence?

A: The key issue here is under-vaccination. To protect a community from outbreaks, about 95% of the population needs to have been vaccinated. In some low-income countries, the rates are down around 60-70%, and weve seen large measles outbreaks and measles-related deaths in those areas. Childhood vaccination and preventive health care was disrupted with the COVID-19 pandemic, putting these populations at even greater risk.

In the U.S., where the high rate of vaccination was a tremendous success in reducing measles, anti-vax trends have led to communities becoming more susceptible. Most of the recent U.S. cases have been related to international travel, and then those cases have sparked outbreakslike the ones in the past few months in Philadelphia and Broward County, Florida.

Q: The drop in vaccination rates is alarming. What are some of the cultural and political drivers that are leading people to question vaccines?

A: I dont study cultural and political drivers, so here are a few of my guesses. The level of misinformation and disinformation about vaccines and their safety seems like a huge problem. And as I referred to, the lack of access to health care and vaccines, particularly in low-income countries, is another huge problem. The drop in vaccination rates, where past successful vaccination campaigns have made once familiar diseases very rare, may also get at one of the paradoxes of public health: With a successful public health intervention, over time people forget about a diseases consequences and come to question the need to continue investing in the intervention.

We need to identify communities and populations where vaccination rates are decreasing or are low enough to warrant concern, so we can better understand the drivers at work and effectively respond to them. We need to counter disinformation, providing forums for trusted health advisors. And we need to redouble our global commitment to providing health careand in this case specifically, providing access to vaccinesfor all.

Maya Brownstein

Photos: iStock/Kittisak Kaewchalun; Kent Dayton

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Measles outbreaks show the risk of under-vaccination | News | Harvard T.H. Chan School of Public Health - HSPH News

Spring Allergy Season Is Getting Worse. Here’s What to Know. – The New York Times

Spring is here and if youre among the estimated one in four adults in the United States who suffers from seasonal allergies, your sneezing and scratching may have already started.

With climate change affecting temperatures and plant growth, you may need to be on the lookout earlier than ever before. It can be hard to distinguish allergy symptoms from those of a cold, but experts point to a few telltale signs.

Spring allergy seasons are beginning about 20 days earlier than they had, according to an analysis of pollen count data from 60 stations across North America from 1990 to 2018.

That shift can have significant health consequences, said William Anderegg, who is an author of the study and an associate professor of biology at the University of Utah. Other research has shown that very early onset of spring is associated with higher prevalence of allergic rhinitis, also known as hay fever. When people end up sick or in the hospital from uncontrolled allergy symptoms, he said, its because they didnt expect it, and didnt have medications in hand.

The researchers also found that pollen concentrations have risen about 20 percent nationwide since 1990, with Texas and the Midwest having the greatest increases. Warmer temperatures, higher concentrations of carbon dioxide and increased precipitation can all contribute to plants growing bigger and producing more pollen over longer periods of time, Dr. Anderegg said.

Dr. Gailen Marshall, chair of the allergy and immunology department at the University of Mississippi Medical Center, said that when he began practicing nearly 40 years ago, allergy seasons were confined to about eight weeks each. Tree pollen hit in the spring, grass pollen increased in spring and summer and ragweed pollen picked up in late summer and early fall.

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Spring Allergy Season Is Getting Worse. Here's What to Know. - The New York Times