Emergency department intervention aids in long-term smoking cessation – News-Medical.Net

An opportunistic emergency department stop smoking prompt, comprising brief advice by a trained professional, an e-cigarette starter kit, and referral to local stop smoking services can help smokers quit, with a significant proportion of them still not smoking 6 months later, finds research published online inEmergency Medicine Journal.

Some 6.4 million people in the UK still haven't stubbed out for good, and of the large numbers of people attending emergency departments, a substantial proportion are more likely to be smokers and have poorer overall health, explain the researchers.

While initiatives in emergency departments to help people stop smoking have shown promise, it's not clear how well they work over the long term and what elements of them are most effective.

In a bid to find out, the researchers compared usual care with the real-world effectiveness of a brief intervention based in an emergency department to help smokers quit over a 6 month period in the Cessation of Smoking Trial in the Emergency Department (COSTED).

Between January and August 2022, they recruited 972 (out of 1443 screened) adult daily smokers attending the emergency department for medical treatment or accompanying someone who needed it.

Half the participants (484) were randomly allocated to the intervention arm and given brief smoking cessation advice of up to 15 minutes and an e-cigarette starter kit plus advice on its use (up to 15 minutes), as well as a referral to local stop smoking service.

The advice was delivered by a dedicated stop smoking advisor while the patient was waiting to be seen or after discharge. It was tailored to their presenting condition-;for example, discussing how not smoking improved wound healing for patients with cuts.

The local stop smoking service routinely followed up with a phone call offering support and, if taken up, advice on how to quit, as well as free provision of nicotine replacement therapy (NRT).

The rest of the participants (488) were randomly allocated to the comparison arm of the trial and given written details of local NHS stop smoking services but weren't referred directly.

Those reporting that they had stopped smoking at the 6 month assessment were asked to take a carbon monoxide test to biochemically confirm this.

After 6 months, continuous abstinence was just over 7% (35/484) in the intervention group and just over 4% (20/488) in the comparison group, meaning that those given the prompt were 76% more likely to have stopped smoking than those merely signposted to smoking cessation services.

Self-reported 7-day abstinence at 6 months was just over 23% (113/484) in the intervention group and 13% (63/488) in the comparison group.

Those in the intervention group were also more likely to make quit attempts than those in the comparison group: 2 (14) vs 1 (03). And of those who responded to this query, nearly 40% (125/317) were using an e-cigarette daily at this point.

No serious side effects associated with taking part in the trial were reported.

The researchers acknowledge that those in the comparison group were supported rather more than perhaps would have been the case normally, and managing to obtain a carbon monoxide test to confirm trial participants had stopped smoking proved "very challenging," they add.

But they point out: "These results strengthen previous findings that [emergency department]-based smoking cessation interventions are effective. To our knowledge, the 6-month self-reported quit rate is the highest reported by any [such] smoking cessation intervention trial to date."

They conclude: "We consider that this could be rolled out to reach a large proportion of current smokers, although dedicated staff are clearly needed to deliver the intervention soas not to burden clinical staff."

And this approach is also likely to narrow health inequalities, they suggest: "Those attending [emergency departments] are generally from more deprived communities and more likely to smoke than the general population. Therefore, this intervention has the potential to address health inequalities that arise from disparities in smoking rates between different socioeconomic groups."

In a linked editorial, Drs Gina Kruse and Jon Samet of the University of Colorado and Dr Joaquin Barnoya of the Integra Cancer Institute, Guatemala City, add that "the high uptake of the trial interventions makes a compelling argument for the potential of a cessation package that includes e-cigarettes for [emergency department] patients."

But as nearly 40% of participants in the intervention arm were using e-cigarettes daily and over half at least weekly during the 6 month follow-up period, they sound a note of caution.

"We need more information on the long-term use of e-cigarettes after cessation of combustible cigarettes, owing to concerns that persistent use is likely to be seen as a favourable finding by the e-cigarette industry that would profit from continued nicotinedependence," they write.

And they conclude: "We need to measure the harms to adolescents hand in hand with the potential for benefits to combustible cigarette users if we are to generate informed policies and practices about these devices."

Source:

Journal reference:

Pope, I., et al. (2024). Cessation of Smoking Trial in the Emergency Department (COSTED): a multicentre randomised controlled trial.Emergency Medicine Journal. doi.org/10.1136/emermed-2023-213824.

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Emergency department intervention aids in long-term smoking cessation - News-Medical.Net

Atrium Health Floyd EMS Named Georgia’s Service of the Year – Coosa Valley News

Atrium Health Floyd EMS was named the Georgia EMS Service of The Year during the Georgia Emergency Medical Services Association (GEMSA) awards held Tuesday night in Buford. It marked the fourth time Atrium Health Floyd has earned statewide the award.

Individual honorees for Atrium Health Floyd EMS include:

We strive to provide a team-driven, servant leadership culture within Atrium Health EMS, said Bud Owens, executive director of the service and Atrium Healths EMS leader for the Georgia market. That focus has worked, and our teammates are the best in the industry. They constantly strive to serve our patients, families and communities with a focus on excellence in everything they do. That is why we are successful. They are truly an elite few and I am so proud of them.

Atrium Health Floyd EMS provides emergency ambulance and non-emergency transport services to residents throughout Floyd County, northwest Georgia and Cherokee County in Alabama. It is the designated 911 responder for the majority of Floyd County and all of Chattooga County and Cherokee County, Alabama.

With over 180 teammates consisting of Paramedics, EMTs, telecommunicators, mechanics, support staff and leadership, the bottom-up leadership culture of the organization is recognized across multiple states, the GEMSA news release stated. Over 600 hours of community service and community benefit have been logged during 2023 by teammates who have graciously served the northwest Georgia and northeast Alabama communities through health fairs, educational programs, event coverage, support of athletic events and programs to benefit the health of communities served.

The Joe Lane Cox Excellence in EMS Award recognizes a worthy individual who is not employed in EMS but donates their time and efforts to continue the improvement of EMS on the local, state and national levels.

In her role as emergency preparedness coordinator, Holcomb is constantly going out of her way to include EMS in every aspect of her job and to any benefit of the community, according to the GEMSA news release. Her main goal is to have the community comfortable with EMS and to educate the public on the capabilities of an EMS service.

Eickleberry received the Georgia Emergency Medical Technician of The Year for her skill, knowledge and dedication to her teammates and her community.

She is an advanced EMT who serves in a dual role with capabilities of running her own AEMT truck and is confident enough to support any need her paramedic partner may need, according to the news release.

She often buys groceries and other items to help someone less fortunate. She has also been known to cook a meal for a patient in need.

The amount of kindness and compassion she shows to all she meets is a testament to her servant leadership qualities, the news release stated.

Atrium Health Floyd EMS held the most nominations statewide and was recognized with placement in the top three in 12 of the 13 award categories.

Other Atrium Health EMS nominees were Dr. Kevin Hardwell,Greg Goedert, Ben Fleming, Amber Eason, Cristy Harris, Megan Dozier, Darby Hopper, Daniel Herring, Dusty Johnson, Robby Hill and Don Taylor.

The statewide awards come after Atrium Health Floyd EMS also earned recognition on the regional level.

Paramedic Dusty Johnson was named the Danny Hall Memorial Paramedic of the Year by Northwest Georgia Region 1 EMS.

Johnson has been a teammate at Atrium Health Floyd since 2018 and serves as both a responder and an instructor for EMS.

Dusty has invested himself in the people he works with and those whom he treats. Being a great paramedic is more than performing emergency medicine on a scene. It is also about helping others reach the same high standard, a nomination letter for Johnson stated.

Amber Eason and Ben Fleming earned the Richard Gray M.D. Excellence in Trauma award. Gray was the trauma surgeon at Floyd Medical Center when it became Georgias first designated trauma center in 1981.

They were honored for their response to an incident when a woman was seriously injured after possibly being hit by a train on June 17, 2023.

The patients survival was due to the care and work of Amber, Ben and the Rome-Floyd Fire Department, according to the nomination letter.

Atrium Health Floyd EMS teammates were also recognized last year as Hospital Heroes by the Georgia Hospital Association for their response to a tragic wreck in Chattooga County in October 2022.

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Atrium Health Floyd EMS Named Georgia's Service of the Year - Coosa Valley News

The anti-abortion endgame Erin Hawley admitted to the Supreme Court. – Slate

Somewhat lost in the debate around abortion pills and oral arguments that took place at the Supreme Court in FDA v. Alliance for Hippocratic Medicine on Tuesday was one deeply uncomfortable truth: The very notion of what it means to practice emergency medicine is in dispute, with anti-abortion doctors insisting upon a right to refuse treatment for any patient who doesnt meet their test of moral purity. Indeed, the right asserted is that in the absence of certainty about which patients are morally pure, the doctors want to deny medication to all patients, nationwide.

In public, the plaintiffs in this casea group of doctors and dentists seeking to ban medication abortionhave long claimed they object to ending unborn life by finishing an incomplete or failed abortion at the hospital. But in court, they went much further. Their lawyer, Erin Hawley, admitted at oral argument that her clients dont merely oppose terminating a pregnancythey are pursuing the right to turn away a patient whose pregnancy has already been terminated. Indeed, they appear to want to deny even emergency care to patients whose fetus is no longer alive, on the grounds that the patient used an abortion drug earlier in the process. And they aim todeploy this broad fear of complicity against the FDA, to demand a nationwide prohibition on the abortion pill to ensure that they need never again see (and be forced to turn away) patients whove previously taken it. This is not a theory of being complicit in ending life. It is a theory that doctors can pick and choose their patients based on the moral distress they might feel in helping them.

It should come as no surprise that the same judge who tried to ban mifepristone in this case, Matthew Kacsmaryk, has also attempted to legalize anti-LGBTQ+ discrimination in health care nationwide. This is the ballgame: weaponize subjective religious beliefs against secular society to degrade the quality of care for everyone. If you cant persuade Americans to adopt hardcore evangelical views, exploit the legal system to coerce them into it anyway.

Alliance for Hippocratic Medicine is at once embarrassingly frivolous and existentially important. Dont let the jokes about how silly the Comstock Act seems, or how speculative the theory of standing is, get in the way of taking a serious look at the claims on offer. The plaintiffs say they are terrified that one day, a patient may walk into their emergency room suffering complications from a medication abortion prescribed by some other doctor. This patient may need their assistance completing the abortion or simply recovering from the complete abortion, which these plaintiffs deem complicity in sin. And they say the solution is either a total, nationwide ban on mifepristone, the first drug in the medication abortion sequence, or a draconian (and medically unnecessary) set of restrictions that would place mifepristone out of reach for many patients. (The U.S. Court of Appeals for the 5th Circuit ruled to reinstate those restrictions at their behest.)

It is a twisted line of logic, one that should never have reached the Supreme Court in the first place. But it is also a product of the courts past indulgence of outlandish claims about moral complicity. As was made plain in the oral arguments and briefing, activist doctors are no longer satisfied with personal conscience exemptions already granted under state and federal law; they now insist that nobody, anywhere, should have access to the abortion pill, in order to ensure that they themselves wont have to treat patients who took one. At a minimum, they say, they should be able to radically roll back access to the pill in all 50 states to reduce the odds that one of these handful of objectors might someday encounter a patient who took it. This extremist argument lays bare the transformation of the idea of complicity from a shield for religious dissenters to a sword for ideologues desperate to seize control over other peoples lives and bodies.

At oral arguments, several justices pressed Hawley, who argued on behalf of Alliance for Hippocratic Medicine, with an obvious retort: Why cant her clients simply refuse to treat these hypothetical someday patientson the grounds that they cannot help end the life of a fetus or embryo? After all, federal law guarantees doctors the right not to have to provide an abortion if doing so is contrary to his religious beliefs or moral convictions. Justices Amy Coney Barrett and Brett Kavanaugh secured assurances from Solicitor General Elizabeth Prelogar, early in the arguments, that under no circumstances could the government force any health care provider to ever participate in an abortion in violation of their conscience. Justice Elena Kagan asked Prelogar: Suppose somebody has bled significantly, needs a transfusion, or, you know, any of a number of other things that might happen. Would the plaintiffs object to treating them? Prelogar said the record was unclear.

Hawley, who is married to far-right Republican Sen. Josh Hawley, then approached the lectern and cleared up any confusion: Yes, she insisted, treating a patient who has undergone a medication abortion violates the conscience of the plaintiff physicians even if there is no live fetus or embryo to terminate anymore. Completing an elective abortion means removing an embryo fetus, whether or not theyre alive, as well as placental tissue, Hawley told Kagan. So the plaintiffs dont object just to taking a life. They also object to the mere act of removing leftover tissue, even from the placenta.

Of course, these doctors must remove dead fetal tissue and placentas all the timefrom patients who experienced a spontaneous miscarriage. By their own admission, the plaintiffs regularly help women complete miscarriages through surgery or medication. Those women they will gladly treat. Other women, thoughthe ones who induced their own miscarriage via medicationare too sinful to touch. Before the plaintiffs can administer even lifesaving emergency treatment, they need to know the circumstances of this pregnancy loss: Spontaneous miscarriages are OK; medication abortions are not.

Justice Ketanji Brown Jackson, too, zeroed in on this admission. She told Hawley that she had thought the objection was to participating in a procedure that is ending the life [of the fetus]. Hawley told her no: Any participation in an abortion, even through the indirect treatment of a patient without a live fetus, violated the doctors conscience. So, wait. What about handing them a water bottle? Jackson asked. Hawley dodged the question, declining to say whether helping a patient hydrate would constitute impermissible complicity in sin.

All this is reminiscent of Little Sisters of the Poor, a case about a Catholic charitable group that was afforded an exemption from the Affordable Care Acts contraception mandate. The Little Sisters were asked to check a box signaling to the government that they could not comply with the mandate, at which point the government would step in to cover their employees. But the Little Sisters refused, viewing this actionthe checking of a box to opt out of coverageas complicity in abortion because it would in turn trigger government payment for contraception (which they viewed as abortifacients). The Supreme Court and the Trump administration ultimately indulged the Little Sisters claim.

Here, we have emergency room physicians asserting that they will not participate in lifesaving medical intervention unless they approve of the reason for the pregnancy loss. Presumably, if the pregnant patient is an unwed mother, or a gay or transgender person, the doctor would be similarly complicit in sin and decline service. Seen through this lens, since one can never know which sins one is enabling in the ER, each and every day, a narrow conscience exemption becomes a sweeping guarantee that absolutely nobody in the country can ever have access to basic health care, let alone miscarriage management. (Of course, these plaintiffs might focus only on one set of sins they see as relevant.) In a country effectively governed by Kacsmaryk and his plaintiff friends, a gay person suffering a stroke could be turned away from any hospital because of his sexual orientation, all to spare a doctor from a glancing encounter with prior sin. As Tobias Barrington Wolff, a professor of law at the University of Pennsylvania Law School, put it to us in an email, this unbounded view of complicity is part of enacting the social death of people and practices you abhor, which in turn can contribute to the material death of people and practices you abhor.

One of the most exhausting lessons of post-Roe America is that being pro-life definitively means privileging the life of the presumptively sin-free unbornor even their dead remainsover the life of the sin-racked adults who carry them. This is why women are left to go septic or to hemorrhage in hospital parking lots; it is why C-sections are performed in nonviable pregnancies, at high risk to mothers; its why the women who sued in Texas to secure exceptions to that states abortion ban are condemned by the state as sinners and whores. And its whyin the eyes of the Alliance for Hippocratic Medicineit is a greater hardship for a physician to waste precious moments scrubbing in, scrubbing out of emergency surgery, as Hawley put it, so long as they dont believe that the emergency warrants their professional services, than it is for a pregnant person, anywhere in the country, including in states that permit abortion, to be forced to give birth.

At oral argument, Hawley explained that her clients have structured [their] medical practice to bring life into the world. When they are called from their labor and delivery floor down to the operating room to treat a woman suffering from abortion drug harm, that is diametrically opposed to why they entered the medical profession. It comes along with emotional harm. The emotional harm alleged here is that unless these doctors approve of the specific circumstances of the ER visit, they violate not only their own medical preference but also their religious convictions. But they will never truly know enough about the sins of their patients to be able to shield themselves against being a link in a chain of subjective lifelong sin. And to be a doctor, especially an emergency physician, should be to understand that your patients private choices and spiritual life are not really open to your pervasive and vigilant medical veto. This deep-rootedsuspicion of patients deemed insufficiently pure for lifesaving treatment didnt begin with the availability of medication abortion. It will assuredly not end there.

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The anti-abortion endgame Erin Hawley admitted to the Supreme Court. - Slate

Enhancing CT Scanner Efficiency in ED for Trauma Team Activations – Physician’s Weekly

The following is a summary of Improving CT scanner efficiency for trauma team activations in the emergency department, published in the January 2024 issue of Emergency Medicine by Zwank, et al.

Trauma Team Activation (TTA) protocols are crucial for efficiently managing life or limb-threatening injuries in emergency departments (EDs). However, delays in stabilizing patients can lead to idle time for CT scanners, impacting overall patient care. For a quality improvement project, researchers sought to assess the impact of implementing a new policyproviding a 5-min heads-up (5-min HU) notification to CT scanner personnel once a TTA patient was stabilizedon reducing CT scanner idle time.

They conducted a prospective study at a large, urban Level I Trauma Center in November 2022. They tracked incoming TTAs and recorded time points, including TTA notification, 5-minute HU notification, and arrival at the CT scanner. Data were analyzed using a non-parametric comparison test (Mann-Whitney U).

A total of 46 TTAs were included in the analysis, with the majority resulting from blunt trauma (85%) and penetrating trauma (15%). The median time from the initial TTA announcement to CT arrival was 24.0 minutes (IQR: 9.0 min). With the 5-min HU policy, the median time from notification to CT arrival was 5.0 minutes (IQR: 4.0 min), resulting in a median of 19 minutes of CT scanner idle time saved per patient compared to the previous policy (P < 0.0001). Overall, the new policy saved 818 minutes (13.6 hours) of CT scanner time.

Implementing the 5-min HU policy in the ED for TTA patients significantly reduced CT scanner idle time, optimizing resource utilization and potentially improving care for all patients in the ED. It underscored the importance of proactive communication strategies in trauma care protocols to enhance efficiency and patient outcomes.

Reference: sciencedirect.com/science/article/abs/pii/S073567572300582X

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Enhancing CT Scanner Efficiency in ED for Trauma Team Activations - Physician's Weekly

University Hospitals: New Urgent Care building opens in Medina | wkyc.com – WKYC.com

As of Monday, March 25, the former location at 4001 Carrick Drive is now closed and the new location at 716 North Court Street will serve as the new facility.

MEDINA, Ohio The University Hospitals Urgent Care location in Medina officially made the move to a new location.

As of Monday, March 25, the former location at 4001 Carrick Drive is now closed and the new location at 716 North Court Street will serve as the UH Urgent Care Medina location.

Our UH Urgent Care delivery model aims to provide the most convenient and valuable care for our patients, explained UH Chief Operating Officer Paul Hinchey, MD, MBA. Having easy access to urgent care locations provide a more affordable option than emergency departments for patients who dont have a primary care physician but need immediate, non-life-threating medical attention. By offering more urgent care locations, we can relieve the burden on emergency departments and reduce wait times so our emergency medicine teams can focus on critical cases.

UH says services on site include x-ray, lab, EKG, medication dispensing and more.

The new location's hours are 8 a.m. to 8 p.m. every day. Hours may differ on holidays.

"Our primary goal is to reimagine urgent care for Northeast Ohio by removing obstacles and easing access to care while delivering exceptional patient experiences, Dr. Resnick said. The expansion of UH Urgent Care in Northeast Ohio is a significant step towards fulfilling this commitment. By increasing access to urgent care services, we aim to make a positive impact on the lives of individuals and families throughout the region, providing them with the prompt and effective care they deserve in retail locations where they live, shop and work."

UH says the move to the new building will help reduce travel time of Medina residents thanks to the more centrally located facility.

Want to be among the first to know the most important local and national news? Download the free WKYC app and get updates right on your phone: Android, Apple.

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University Hospitals: New Urgent Care building opens in Medina | wkyc.com - WKYC.com

Awareness of Urgent Care Services Among Primary Healthcare Center Patients in Al-Ahsa, Saudi Arabia – Cureus

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Study links long-term consumption of deep-fried oil with increased neurodegeneration – ASBMB Today

A new study found higher levels of neurodegeneration in rats that consumed reused deep fried cooking oils and their offspring compared to rats on a normal diet. Deep frying, which involves completely submerging food in hot oil, is a common method of food preparation around the world.

Results from the study also suggest that the increased neurodegeneration is tied to the oils effects on the bidirectional communication network between the liver, gut and brain. The livergutbrain axis plays a crucial role in regulating various physiological functions, and its dysregulation has been associated with neurological disorders.

All that oil could be going to your head. Research presented at Discover BMB in San Antonio found higher levels of neurodegeneration in rats that consumed reused deep fried cooking oils compared to rats on a normal diet.

Kathiresan Shanmugam, an associate professor from Central University of Tamil Nadu in Thiruvarur, led the research team.

Deep-frying at high temperatures has been linked with several metabolic disorders, but there have been no long-term investigations on the influence of deep-fried oil consumption and its detrimental effects on health, said Shanmugam, formerly at Madurai Kamaraj University, Madurai. To our knowledge we are first to report long-term deep-fried oil supplementation increases neurodegeneration in the first-generation offspring.

Sugasini Dhavamani, a research collaborator from the University of Illinois at Chicago, will present the research at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, which will be held March 2326 in San Antonio.

Deep frying food not only adds calories; reusing the same oil for frying, a common practice in both homes and restaurants, removes many of the oils natural antioxidants and health benefits. Oil that is reused also can contain harmful components such as acrylamide, trans fat, peroxides and polar compounds.

To explore the long-term effects of reused deep-fried frying oil, the researchers divided female rats into five groups that each received either standard chow alone or standard chow with 0.1 ml per day of unheated sesame oil, unheated sunflower oil, reheated sesame oil or reheated sunflower oil for 30 days. The reheated oils simulated reused frying oil.

Compared with the other groups, the rats that consumed reheated sesame or sunflower oil showed increased oxidative stress and inflammation in the liver. These rats also showed significant damage in the colon that brought on changes in endotoxins and lipopolysaccharides toxins released from certain bacteria. As a result, liver lipid metabolism was significantly altered, and the transport of the important brain omega-3 fatty acid DHA was decreased. This, in turn, resulted in neurodegeneration, which was seen in the brain histology of the rats consuming the reheated oil as well as their offspring.

Additional studies in which MSG was used to induce neurotoxicity in the offspring showed that the offspring that consumed the reheated oils were more likely to show neuronal damage than the control group receiving no oil or those that received unheated oil.

Although more studies are needed, the researchers say that supplementation with omega-3 fatty acids and nutraceuticals such as curcumin and oryzanol might be helpful in reducing liver inflammation and neurodegeneration. They added that clinical studies in humans are needed to evaluate the adverse effects of eating fried foods, especially those made with oil that is used repeatedly.

As a next step, the researchers would like to study the effects of deep-frying oil on neurodegenerative diseases such as Alzheimers and Parkinsons as well as on anxiety, depression and neuroinflammation. They would also like to further explore the relationship between gut microbiota and the brain to identify potential new ways to prevent or treat neurodegeneration and neuroinflammation.

Sugasini Dhavamani will present this research during a poster session from 4:30 to 6:30 p.m. CDT on Sunday, March 25, in the exhibit hall of the Henry B. Gonzlez Convention Center (Poster Board No. 326) (abstract).

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Study links long-term consumption of deep-fried oil with increased neurodegeneration - ASBMB Today

Plants have an astonishing biochemical communication network – Earth.com

Researchers at Purdue University have made significant strides in understanding plant communication through chemical signals, revealing their intricate language.

Plants, incapable of movement, have evolved unique mechanisms for survival and communication, particularly through Volatile Organic Compounds (VOCs).

These compounds serve as distress signals, warning neighboring plants of potential dangers, such as insect attacks or diseases.

Natalia Dudareva, a Distinguished Professor at Purdue in the departments of Biochemistry and Horticulture and Landscape Architecture, emphasizes the importance of VOCs in plant communication.

She describes it as a form of immunization, where plants primed by these signals respond more vigorously to threats, despite showing no visible changes under normal conditions.

Plants inform neighboring plants about pathogen attacks. It looks almost like immunization. Under normal conditions, you dont see any changes in the receiver plant. But as soon as a receiver plant is infected, it responds much faster. Its prepared for response, explained Dudareva.

The concept of plants communicating through VOCs is not new to science, but the mechanisms behind this communication have remained largely unexplored due to the lack of identifiable markers.

However, recent discoveries by Dudareva and her team have shed light on this process. Their research has documented how petunias produce volatiles to sterilize parts of their flowers, protecting against microbial invasion.

This discovery, first published in 2019, also introduced stigma size as a reliable marker for studying inter-organ communication in plants.

Shannon Stirling, a Ph.D. student at Purdue and the studys lead author, has contributed significantly to this research.

Through meticulous analysis, including measurements of stigma size affected by exposure to VOCs, Stirlings work has helped establish a consistent trend in the communication process.

There are a lot of sugars on the stigma, especially in petunias. It means that bacteria will grow very nicely without these volatiles present, Dudareva explained.

But if the stigma does not receive tube-produced volatiles, its also smaller. This was interorgan communication. Now we had a good marker stigma size to study this communication process, she concluded.

This trend is further supported by genetic studies that pinpointed a karrikin-like signaling pathway as a crucial element in this communication.

Karrikins, interestingly, are compounds not produced by plants but are associated with smoke or fire exposure, raising intriguing questions about plant evolutionary biology.

The study also highlights the exceptional selectivity of plant receptors, particularly in recognizing specific sesquiterpene compounds.

Matthew Bergman, a postdoctoral researcher and co-author of the study, points out the receptors ability to differentiate between mirror images of compounds, emphasizing the precision of this signaling system in avoiding false triggers.

The plant produces many different volatile compounds and is exposed to plenty of others, Bergman said. Its quite remarkable how selective and specific this receptor is exclusively for this signal being sent from the tubes. Such specificity ensures that no other volatile signals are getting by. Theres no false signaling.

Stirlings expertise in protein manipulation has been pivotal in identifying the interactions between signaling molecules and receptors. The process involves delicate techniques to modify protein levels in petunia pistils, a challenging task given the small size of these organs.

Pistils and stigmas are small. Theyre a little difficult to work with because of their size, Stirling said. Even the sheer amount of stigmas you need to get enough sample for anything is quite large because they dont weigh much.

This methodological breakthrough could pave the way for further discoveries in plant signaling and communication.

Petunias, with their vivid colors and fragrances, are more than just a visual delight. As Bergman notes, their value extends into the realm of scientific research, serving as an effective model for understanding complex biological processes.

In summary, this fascinating research has peeled back the layers of mystery surrounding plant communication. These brilliant scientists discovered how petunias, through the sophisticated use of volatile organic compounds, communicate threats to their neighbors. This communication, in turn, effectively immunizes them against potential dangers.

This study highlights the intricacies of plant signaling pathways, particularly through the discovery of the karrikin-like signaling mechanism and the precise receptor specificity for sesquiterpene compounds, while setting the stage for future research in plant biology.

By advancing our understanding of these complex communication systems, scientists unlock new possibilities for enhancing plant resilience and health, paving the way for agricultural innovations and environmental conservation strategies.

As discussed above, Volatile Organic Compounds (VOCs) represent a vast group of chemicals that plants and other organisms naturally emit. These compounds easily evaporate at room temperature, making them a significant part of the air we breathe.

In the plant kingdom, VOCs serve as critical components in a sophisticated communication network. They play pivotal roles in attracting pollinators, deterring herbivores, and signaling neighboring plants about environmental stressors.

Plants utilize VOCs to convey vital information to their surroundings. This form of communication is especially crucial in responding to threats such as herbivore attacks or disease.

When a plant gets damaged, it releases specific VOCs into the air. These signals can directly repel pests or attract natural enemies of the pests, such as predators or parasitoids, effectively reducing the damage to the plant.

Moreover, VOCs are not just about defense. They are instrumental in forming symbiotic relationships and facilitating plant-to-plant interactions.

For example, when one plant is attacked, neighboring plants can detect the VOCs released and preemptively bolster their own defenses, a phenomenon known as priming. This capability suggests a level of interconnectedness and communal support among plant populations.

Beyond defense, plants produce VOCs to lure pollinators. These chemical signals can attract specific insects or animals, ensuring the plants reproductive success.

The diverse array of scents and odors produced by flowers is primarily due to VOCs, tailored to appeal to the plants pollinators, whether they be bees, birds, or bats.

Furthermore, VOCs facilitate symbiotic relationships between plants and microorganisms. Certain VOCs can attract beneficial microbes that help the plant absorb nutrients more efficiently or provide resistance against pathogens.

This interaction underscores the complexity of VOCs in plant ecology, extending beyond plant-to-plant communication to encompass a broader ecological network.

The exchange of VOCs among plants and between plants and other organisms significantly influences ecosystem dynamics. It affects plant competition, biodiversity, and the structure of plant communities.

VOCs can mediate the outcome of plant interactions, determining which species dominate in certain conditions and contributing to the overall health and resilience of ecosystems.

As discussed above, Volatile Organic Compounds are more than mere byproducts of plant metabolism. They are vital communicative tools that plants use to interact with their environment.

Through the release of VOCs, plants can defend against predators, attract pollinators, and communicate with neighboring flora, showcasing a sophisticated level of interaction that mirrors the complexity of animal communication networks.

As research in this field progresses, we continue to uncover the depth and breadth of plant communication, revealing an intricate world where plants are far from passive entities in their ecosystems.

This study, which appears in the March 22, 2024, issue of the journal Science, is a collaborative effort involving scientists from Purdue, Universit Jean Monnet Saint-Etienne in France, and the University of California-Davis.

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Yale men’s basketball confused for university’s Molecular Biophysics and Biochemistry on Twitter – Sporting News

Yale men's basketball's recent success has had the masses flocking for a glimpse at the inner workings of the team. Any piece of content relating to the team is susceptible to being devoured by the public. Sometimes, that can even sweep up entities unrelated to the basketball team at hand.

Yale's Molecular Biophysics and Biochemistry program was the latest department to get caught in the Bulldogs' riches. The world-renowned institution has been largely overshadowed by its nouveau riche supernovas in recent days. The most glaring example of such a phenomenon? The number of Twitter replies directed toward the molecular biophysics and biochemistry department in the first place.

There's been a massive groundswell of Twitter users interested in contacting the storied research org over the past few days. The reason for such interest is because Yale's Molecular Biophysics and Biochemistry has a rather familiar Twitter username: @YaleMBB.

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Many seem to believe that @YaleMBB's Twitter account is the same as Yale men's basketball's Twitter account. That is not actually the case. The Bulldogs are represented by the Twitter account @YaleMBasketball.

Have no fear, though: Yale's Molecular Biophysics and Biochemistry made it clear that they are the original @YaleMBB, not the other way around.

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From their Twitter account:

The social media account even took the unprecedented step of adding an addendum to its Twitter bio, stating the following:

'Yale Molecular Biophysics and Biochemistry (not @YaleMBasketball)'

Whether that piece of context will appease the masses is anyone's guess. Misinformation is rife in today's age.

Nevertheless, those hoping to get their fix of all things molecular biophysics and biochemistry will surely be pleased with their beloved program's desire to stick up for themselves, even if it's at the expense of one of its host university's most-beloved institutes.

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Yale men's basketball confused for university's Molecular Biophysics and Biochemistry on Twitter - Sporting News

Study suggests that estrogen may drive nicotine addiction in women – EurekAlert

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Researchers discovered that estrogen induces the expression of olfactomedins (OLFM), proteins that are suppressed by nicotine in key areas of the brain involved in reward and addiction. The research could lead to new targeted therapies that help women control nicotine consumption.

Credit: Sally Pauss, University of Kentucky College of Medicine; created with BioRender.com

A newly discovered feedback loop involving estrogen may explain why women might become dependent on nicotine more quickly and with less nicotine exposure than men. The research could lead to new treatments for women who are having trouble quitting nicotine-containing products such as cigarettes.

Sally Pauss is a doctoral student at the University of Kentucky College of Medicine in Lexington. She led the project.

Studies show that women have a higher propensity to develop addiction to nicotine than men and are less successful at quitting, said Pauss, who is working under the supervision of Terry D. Hinds Jr., an associate professor. Our work aims to understand what makes women more susceptible to nicotine use disorder to reduce the gender disparity in treating nicotine addiction.

The researchers found that the sex hormone estrogen induces the expression of olfactomedins, proteins that are suppressed by nicotine in key areas of the brain involved in reward and addiction. The findings suggest that estrogennicotineolfactomedin interactions could be targeted with therapies to help control nicotine consumption.

Pauss will present the research at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, which will be held March 2326 in San Antonio.

Our research has the potential to better the lives and health of women struggling with substance use, she said. If we can confirm that estrogen drives nicotine seeking and consumption through olfactomedins, we can design drugs that might block that effect by targeting the altered pathways. These drugs would hopefully make it easier for women to quit nicotine.

For the new study, the researchers used large sequencing datasets of estrogen-induced genes to identify genes that are expressed in the brain and exhibit a hormone function. They found just one class of genes that met these criteria: those coding for olfactomedins. They then performed a series of studies with human uterine cells and rats to better understand the interactions between olfactomedins, estrogen and nicotine. The results suggested that estrogen activation of olfactomedins which is suppressed when nicotine is present might serve as a feedback loop for driving nicotine addiction processes by activating areas of the brains reward circuitry such as the nucleus accumbens.

The researchers are now working to replicate their findings and definitively determine the role of estrogen. This knowledge could be useful for those taking estrogen in the form of oral contraceptives or hormone replacement therapy, which might increase the risk of developing a nicotine use disorder.

The investigators also want to determine the exact olfactomedin-regulated signaling pathways that drive nicotine consumption and plan to conduct behavioral animal studies to find out how manipulation of the feedback loop affects nicotine consumption.

Sally Pauss will present this research during a poster session from 4:306:30 p.m. CDT on Monday, March 25, in the exhibit hall of the Henry B. Gonzlez Convention Center (Poster Board No. 152) (abstract). Contact the media team for more information or to obtain a free press pass to attend the meeting.

Image available.

About the American Society for Biochemistry and Molecular Biology (ASBMB)

The ASBMB is a nonprofit scientific and educational organization with more than 12,000 members worldwide. Founded in 1906 to advance the science of biochemistry and molecular biology, the society publishes three peer-reviewed journals, advocates for funding of basic research and education, supports science education at all levels, and promotes the diversity of individuals entering the scientific workforce. http://www.asbmb.org

Find more news briefs at: https://discoverbmb.asbmb.org/newsroom.

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Study suggests that estrogen may drive nicotine addiction in women - EurekAlert