Biogen to buy Human Immunology Biosciences in deal worth up to $1.8B – MM+M Online

Biogen announced it will buy Human Immunology Biosciences (HI-Bio) in a deal worth up to $1.8 billion Wednesday morning.

Per terms of the transaction, Biogen will make an upfront payment of $1.15 billion to HI-Bio and the latters stockholders will be eligible for payments of up to an additional $650 million dependent on developmental milestones for the felzartamab programs.

The transaction is being financed by Biogens cash reserves and is expected to close in Q3, following customary closing conditions and regulatory approvals.

Felzartamab is HI-Bios lead investigational therapeutic human monoclonal antibody directed against CD38. The asset was originally developed by MorphoSys AG for treating multiple myeloma and has shown the ability to selectively deplete CD38+ plasma cells and natural killer cells in multiple Phase 2 studies.

This has prompted HI-Bio to plan on advancing these indications including primary membranous nephropathy (PMN), antibody-mediated rejection (AMR) and IgA nephropathy (IgAN) to Phase 3 trials.

Additionally, Biogen is picking up izastobart/HIB210, an anti-C5aR1 antibody currently in a Phase 1 trial, as well as HI-Bios discovery stage mast cell programs focused on treating a range of immune-mediated diseases.

Biogen stated in a company press release that it seeks to retain expertise and talent from HI-Bio and create a team based in the Bay Area to expand its efforts in immune-mediated diseases.

We believe this late-stage asset, which has demonstrated impact on key biomarkers and clinical endpoints in three renal diseases with serious unmet needs, is a strategic addition to the Biogen portfolio as we continue to augment our pipeline and build on our expertise in immunology, said Priya Singhal, MD, MPH, head of development at Biogen, in a statement. We look forward to welcoming HI-Bio employees into Biogen and, together, working to advance potential therapies for patients with rare immune diseases with high unmet need.

The HI-Bio deal was released about a month afterBiogen topped analyst expectationswith its latest quarterly earnings report.

While Biogens total revenue dropped 7% to $2.2 billion, its GAAP operating income grew 10% and its non-GAAP diluted earnings per share (EPS) rose 8% to $3.67 in Q1.

In light of the solid top line performance, Biogen reaffirmed its full-year financial guidance, which is not expected to be negatively impacted by the HI-Bio acquisition.

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Biogen to buy Human Immunology Biosciences in deal worth up to $1.8B - MM+M Online

HIV Vaccine Candidate Induces Broadly Neutralizing Antibodies in Humans – Technology Networks

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Infection with HIV is currently manageable with lifelong antiretroviral medications, but neither a vaccine nor a cure is available. A critical roadblock in preventative vaccine development has been the inability to induce B-cell lineages of broadly neutralizing antibodies (bnAbs) that can combat rapidly evolving strains of the virus.

Now, an HIV vaccine candidate has reportedly triggered low levels of HIV bnAbs among a small group of people enrolled in a 2019 clinical trial.

The findings, reported in the journal Cell, not only provide proof that a vaccine can elicit bnAbs to fight diverse strains of HIV but that it can also initiate the process within weeks.

The vaccine candidate developed at the Duke Human Vaccine Institute targets an area on the HIV-1 outer envelope called the membrane-proximal external region (MPER), which remains stable even as the virus mutates. bnAbs against this stable region in the HIV-1 outer coat can block infection by many different circulating strains of HIV-1.

Discussing the decision to target the MPER of the HIV-1 outer envelope, Dr. Barton Haynes, director of the Duke Human Vaccine Institute, told Technology Networks, The MPER is targeted by the broadest of the neutralizing antibodies. We have isolated a version of MPER bnAbs from a person living with HIV that neutralized 99% of HIV strains.

Interfering with the interaction of the HIV-1 outer envelope with its host cell receptors, bnAbs interrupt viral replication through a mechanism that differs from most antiretroviral drugs. bnAbs can augment host antiviral immune responses by engaging effector responses. Their long in vivo half-life and favorable safety profile make them attractive clinical application candidates.

Potent bnAbs develop in people living with HIV-1, but only rarely and after many months to years after transmission. One of the questions we have worried about for many years is if it will take years to induce bnAbs with a vaccine like it takes for bnAbs to develop in people living with HIV, explained Haynes. Here we found that bnAb lineages developed after the second immunization.

The research team analyzed data from the HVTN 133 Phase 1 clinical trial. Twenty healthy, HIV-negative individuals enrolled in the trial. Fifteen participants received two of four planned doses of the investigational vaccine, and five received three doses.

After two immunizations, the vaccine showed a 95% serum response rate and a 100% blood CD4+ T-cell response rate, indicating strong immune activation.

Crucial immune cells remained in a state of development that allowed them to continue acquiring mutations so that they could evolve alongside the constantly changing virus.

The trial was halted when one participant experienced a non-lifethreatening allergic reaction. We suspect that the allergic reaction was a reaction to polyethelene glycol (PEG) and have studied such responses in vitro, said Haynes. We have evidence that this is the case and have remade the vaccine as a PEG-less MPER peptide-liposome for retesting in humans at lower doses. The latter lower doses because the vaccine worked better in the trial at the low dose.

While scientists have been striving to produce an HIV vaccine since the 1980s, several features of the virus have made it difficult to develop an effective vaccine.

A signature of HIV infection is its vast genetic diversity and the virus's ability to evolve rapidly within and between infected individuals. Scientists have identified that an effective HIV vaccine will need to be able to produce an immune response that can prevent infection by the diverse HIV strains circulating in the world.

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This work shows the feasibility of inducing antibodies with immunizations that neutralize the most difficult strains of HIV and has provided important insights into the design and feasibility of HIV-1 vaccine development efforts.

Discussing the steps they are taking to improve the vaccine, Haynes said, We have added additional regions of the MPER to give the response more potency and breadth. We have deleted PEG from the vaccine, and we have designed mRNAs that boost the responses induced by the original vaccine.

The researchers stress there is still more work to be done to create a more robust response. They hope to replicate what was done in this research with immunogens that target the other vulnerable sites on the virus envelope.

Dr. Barton Haynes was speaking to Blake Forman, Senior Science Writer and Editor for Technology Networks.

About the interviewee:

Dr. Barton Haynes is the Frederic M. Hanes Professor of Medicine and Immunology, and director of the Duke Human Vaccine Institute. Haynes leads a team of investigators working on vaccines for emerging infections, including tuberculosis, pandemic influenza, emerging coronaviruses and HIV/AIDS.

Reference: Williams WB, Alam SM, Ofek G, et al. Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans. Cell. 2024. doi: 10.1016/j.cell.2024.04.033

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HIV Vaccine Candidate Induces Broadly Neutralizing Antibodies in Humans - Technology Networks

COVID-19 Re-Vaccinations Elicit Neutralizing Antibodies Against Future Variants – Technology Networks

The COVID-19 pandemic is over, but the virus that caused it is still here, sending thousands of people to the hospital each week and spinning off new variants with depressing regularity. The viruss exceptional ability to change and evade immune defenses has led the World Health Organization (WHO) to recommend annual updates to COVID-19 vaccines.

But some scientists worry that the remarkable success of the first COVID-19 vaccines may work against updated versions, undermining the utility of an annual vaccination program. A similar problem plagues the annual flu vaccine campaign; immunity elicited by one years flu shots can interfere with immune responses in subsequent years, reducing the vaccines effectiveness.

A new study by researchers at Washington University School of Medicine in St. Louis helps to address this question. Unlike immunity to influenza virus, prior immunity to SARS-CoV-2, the virus that causes COVID-19, doesnt inhibit later vaccine responses. Rather, it promotes the development of broadly inhibitory antibodies, the researchers report.

The study, available online in Nature, shows that people who were repeatedly vaccinated for COVID-19 initially receiving shots aimed at the original variant, followed by boosters and updated vaccines targeting variants generated antibodies capable of neutralizing a wide range of SARS-CoV-2 variants and even some distantly related coronaviruses. The findings suggest that periodic re-vaccination for COVID-19, far from hindering the bodys ability to recognize and respond to new variants, may instead cause people to gradually build up a stock of broadly neutralizing antibodies that protect them from emerging SARS-CoV-2 variants and some other coronavirus species as well, even ones that have not yet emerged to infect humans.

The first vaccine an individual receives induces a strong primary immune response that shapes responses to subsequent infection and vaccination, an effect known as imprinting, said senior authorMichael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine. In principle, imprinting can be positive, negative or neutral. In this case, we see strong imprinting that is positive, because its coupled to the development of cross-reactive neutralizing antibodies with remarkable breadth of activity.

Imprinting is the natural result of how immunological memory works. A first vaccination triggers the development of memory immune cells. When people receive a second vaccination quite similar to the first, it reactivates memory cells elicited by the first vaccine. These memory cells dominate and shape the immune response to the subsequent vaccine.

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To understand how imprinting influences the immune response to repeat COVID-19 vaccination, Diamond and colleagues including first author Chieh-Yu Liang, a graduate student, studied the antibodies from mice or people who had received a sequence of COVID-19 vaccines and boosters targeting first the original and then omicron variants. Some of the human participants also had been naturally infected with the virus that causes COVID-19.

The first question was the strength of the imprinting effect. The researchers measured how many of the participants neutralizing antibodies were specific for the original variant, the omicron variant or both. They found that very few people had developed any antibodies unique to omicron, a pattern indicative of strong imprinting by the initial vaccination. But they also found few antibodies unique to the original variant. The vast majority of neutralizing antibodies cross-reacted with both.

The next question was how far the cross-reactive effect extended. Cross-reactive antibodies, by definition, recognize a feature shared by two or more variants. Some features are shared only by similar variants, others by all SARS-CoV-2 variants or even all coronaviruses. To assess the breadth of the neutralizing antibodies, the researchers tested them against a panel of coronaviruses, including SARS-CoV-2 viruses from two omicron lineages; a coronavirus from pangolins; the SARS-1 virus that caused the 2002-03 SARS epidemic; and the Middle Eastern Respiratory Syndrome (MERS) virus. The antibodies neutralized all the viruses except MERS virus, which comes from a different branch of the coronavirus family tree than the others.

Further experiments revealed that this remarkable breadth was due to the combination of original and variant vaccines. People who received only the vaccines targeting the original SARS-CoV-2 variant developed some cross-reactive antibodies that neutralized the pangolin coronavirus and SARS-1 virus, but the levels were low. After boosting with an omicron vaccine, though, the cross-reactive neutralizing antibodies against the two coronavirus species increased.

Taken together, the findings suggest that regular re-vaccination with updated COVID-19 vaccines against variants might give people the tools to fight off not only the SARS-CoV-2 variants represented in the vaccines, but also other SARS-CoV-2 variants and related coronaviruses, possibly including ones that have not yet emerged.

At the start of the COVID-19 pandemic, the world population was immunologically nave, which is part of the reason the virus was able to spread so fast and do so much damage, said Diamond, also a professor of molecular microbiology and of pathology & immunology. We do not know for certain whether getting an updated COVID-19 vaccine every year would protect people against emerging coronaviruses, but its plausible. These data suggest that if these cross-reactive antibodies do not rapidly wane we would need to follow their levels over time to know for certain they may confer some or even substantial protection against a pandemic caused by a related coronavirus.

Reference:Liang CY, Raju S, Liu Z, et al. Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines. Nature. 2024. doi: 10.1038/s41586-024-07539-1

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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Pasteur Fiocruz Center on Immunology and Immunotherapy is inaugurated in Cear – Fiocruz

Inaugurated this Friday (5/17), the Pasteur Fiocruz Center on Immunology and Immunotherapy, located at Fiocruz Cear, brings together scientists from the Institut Pasteur and Fiocruz, two members of the Pasteur Network, to develop an integrative approach towards immunotherapies applied to both infectious and non-communicable diseases. This scientific cooperation aims to accelerate research in immunology and immunotherapy at regional, national, and international levels. It counts on the support of the Cear state government and the French Ministry for Europe and Foreign Affairs, through its Embassy in Brasilia.

Participating in the inauguration ceremony were the president of Fiocruz, Mario Moreira; the senior executive vice-president of Scientific Affairs at the Institut Pasteur, Christophe dEnfert; the governor of the State of Cear, Elmano de Freitas; the French ambassador to Brazil, Emmanuel Lenain. The Secretary of Science, Technology, Innovation and Health Complex of the Ministry of Health (SECTICS/MS), Carlos Gadelha, was representing the minister of Health, Nisia Trindade. The ceremony also included the participation of the vice-president of Education, Information and Communication (VPEIC/Fiocruz), Cristiani Vieira Machado; the coordinator of the Fiocruz Agenda 2030 Strategy (EFA 2030/Fiocruz), Paulo Gadelha;the coordinator of Fiocruz Cear, Carla Celidnio; the consul general of France, Serge Gas; the special advisor to the Presidency of Fiocruz for Cooperation with French Institutions, Wilson Savino; and the mayor of Eusbio, Acilon Gonalves Pinto Filho, as well as members of the Pasteur Network in the Americas, such as the Institut Armand Frappier, Institut Pasteur de Guadeloupe, Institut Pasteur de Guyanne, Institut Pasteur de So Paulo and Institut Pasteur de Montevideo.

A new model of collaboration

The new Center is located in Fiocruz Cear Campus, in Eusbio, 30 minutes from Fortaleza (the state's capital in Northeastern Brazil), in a building with 2,350 sqm. The Center will also benefit from the structure of Fiocruzs regional unit, created in 2008 and that is today the technological anchor of the Industrial and Technological Health Hub in Cear (Polo Industrial e Tecnolgico da Sade - PITS).

The president of Fiocruz, Mario Moreira, highlighted the Center as a priority project for the Foundation. It is an exemplary project that inspires us not only because of its scientific competence, but also because it is a model of new institutional arrangements that Fiocruz can adopt to develop activities outside of Rio de Janeiro, he emphasized. In addition to the joy that surrounds this celebration, the Center also brings with it a responsibility to contribute to scientific and technological development that can enable new health products, he commented. We have many projects to develop in this region, in the very particular political institutional arrangement, which is the association of federal, state and municipal governments. This basis justifies Fiocruzs success in Cear, he stated.

Moreira, D'Enfert, Martins and Caroline at the Center's reception where a poster pays homage to Louis Pasteur and Oswaldo Cruz (photo: Iratu Freitas)

The vice president of the Institut Pasteur, Christophe DEnfert, highlighted the project as a new step in the long and solid partnership between Brazil and France. Oswaldo Cruz completed his studies in Paris and returned to Brazil founding Fiocruz. There is a little of France in the Foundation, he mentioned. This ambitious project is fully aligned with the strategies of both institutions involved and will certainly create synergies for innovative science and the benefit of both people, he added. Another point highlighted by DEnfert was the institutions commitment to training future generations of scientists in the field of immunology and immunotherapy.

The Secretary of Science, Technology, Innovation and Health Complex of the Ministry of Health (SECTICS/MS), Carlos Gadelha, highlighted the project as an important commitment to regional equity. We are celebrating a concrete possibility of national development. It is a country project that involves regional development, in the Northeast and Cear, he emphasized.

To the governor of Cear, Elmano de Freitas, the event was a moment that changes the history of his people. My pride in being here is being able to say that what we want to migrate from Cear is the scientific knowledge that will be produced here. Not only do we trust science, but we also understand that it is a path to the country's development. Science cannot be done without partnership and cooperation, he reinforced.

Public health strategy

The development of new immunotherapies is an important public health strategy. This kind of treatment is based of the modulation of the immune system and can directly target an infectious agent, damaged cells and tissues, or regulate the immune microenvironment promoting a proper immune response to fight a given disease. It has revolutionized cancer treatment in recent years, but is not restricted to the oncology field. Indeed, its use in treating other non-communicable diseases (NCDs), and infectious diseases is rapidly increasing.

The Center has three priority scientific areas: cancer; infectious and neglected diseases; autoimmune, neurodegenerative and inflammatory diseases. Among the projects hosted by the Center are: the development of Integrin Inhibitors for Treating Neurodegenerative Diseases; the development of Antibody-Drug Conjugates; the development of nanobody/antibody fragments for Neglected Tropical Diseases; CAR-T cells; and immunotherapies to enhance T cell functions to tackle infectious diseases.

Brazil and France have vast and diverse territories, their populations are frequently affected by infectious and tropical neglected diseases caused by viruses, bacteria, parasites and snakebites. Moreover, mosquito-borne diseases such as dengue, chikungunya, yellow fever, malaria and Zika are endemic in some regions of both countries. Additionally, both countries face a rise in non-communicable diseases. This scenario signs an upward demand for innovative therapeutics.

The first bilateral framework agreement envisioning the creation of the Center was defined in 2015, and renewed in 2021. The following year, it was decided that Fiocruz Cear would receive a researcher from Institut Pasteur to contribute in the efforts for integrated research. The chosen was the Brazilian immunologist Caroline Pereira Bittencourt Passaes, who has a Master's and Doctoral Degree from Oswaldo Cruz Institute (IOC/Fiocruz) and has then been working at the Institut Pasteur for eleven years. Amongst others, Caroline is aco-author in the study regarding the third case of AIDS cure.

One of the Centers privileges is having as patrons two of the greatest scientists in the world: Oswaldo Cruz and Louis Pasteur. Its creation represents a significant milestone in the advancement of knowledge in immunology and immunotherapy. Research on these topics is crucial for the development of new prevention, diagnosis and treatment strategies, said the Centers coordinator, Joo Hermnio. The other Center's coordinator, Caroline Passaes, emphasized that the partnership became a reality thanks to the work done in recent years. The space, previously dedicated to the diagnosis of COVID-19, has been given a new meaning and now begins a new phase, with a focus on developing advanced therapies for the benefit of the population, he pointed out.

Coordinator of Fiocruz Cear, Carla Celednio was moved when she cited the project as a reaffirmation of the century-old collaboration between the institutions. This reinforces the driving power of action for one of Fiocruz Cears vocations: the development of new therapies and technologies for the health of our population, she said. This reality would not have been possible if it were not for the actions to decentralize science and technology in the South-Southeast axis, he stated..

At the end of the ceremony, the agreement to create the Pasteur Fiocruz Center on Immunology and Immunotherapy was signed by Mario Moreira, Christophe DEnfert, Joo Hermnio and Caroline Passaes. The occasion also featured the signing of the decree that establishes and regulates the Cear Health Innovation District, lin the municipality of Eusbio, by the governor Elmano de Freitas. After the signing, the group visited the Center and its laboratories. At reception, a plaque pays homage to Oswaldo Cruz and Louis Pasteur.

The Pasteur Fiocruz Center on Immunology and Immunotherapy is directly linked to the General Directorate of the Institut Pasteur and the Fiocruz Presidency. It counts with a Coordinating Committee and a Scientific Advisory Board (SAB). The Coordination Committee is made up of three representatives from the Institut Pasteur, three representatives from Fiocruz; one from the French Embassy in Brazil; and one from the Cear State Government. The SAB has six members, independent experts who carry out their scientific activities in both Europe and South America, jointly appointed by the Institut Pasteur and Fiocruz.

The governor of Cear, Elmano Freitas, and Mario Moreira at the inauguration ceremony (photo: Iratu Freitas)

Operations began even before its inauguration. The day before (5/16), the Pasteur Fiocruz Symposium on Immunology and Immunotherapy was organized, bringing together researchers from different parts of the world and addressing topics on basic and translational immunology, immunotherapies and innovative applications in the area.

The Pasteur Fiocruz Center on Immunology and Immunotherapy will collaborate closely with the Immunobiological Technology Institute (Bio-Manguinhos/Fiocruz), through a research and development laboratory that is being structured. The Center will also work in partnership with universities, research institutes and public or private companies. It functions in a multi-user operating model, which means that the use of the equipments is open to any collaborator who requests it. In addition to the inputs from Fiocruz and the Institut Pasteur, the Center counts on further financial support of the French Ministry for Europe and Foreign Affairs (through its Embassy in Brasilia), the Cear government and the state governmental agency for the development of Science (Funcap, as Portuguese acronym).

A long partnership

The ties linking the Institut Pasteur to Brazil date back to the late nineteenth century when Don Pedro II, then Emperor of Brazil, a strong supporter of scientific research, developed a keen interest in the work of Louis Pasteur. In 1879, Don Pedro II invited Louis Pasteur to Brazil to study and combat the yellow fever epidemic. Although Louis Pasteur could not travel to Brazil, a successful collaboration led to significant financial support from the emperor, which contributed to the creation of the Institut Pasteur in Paris, in 1887. Later on, Brazilian scientist Oswaldo Cruz traveled to Paris in 1897 and worked with the first generation of Pasteurians, including mile Roux. In mid-1899, with his studies completed, Oswaldo Cruz returned to Brazil and founded on May 25, 1900, the Serum Therapeutic Institute, that originated the Oswaldo Cruz Foundation. The rise of the Pasteur Fiocruz Center on Immunology and Immunotherapy represents a new chapter in such story.

The Pasteur Network

The Institut Pasteur and the Oswaldo Cruz Foundation are both members of the Pasteur Network. The Pasteur Network is an alliance of over 30 institutes that plays a crucial role in tackling global health challenges through science, innovation and public health. Its distinctive strength lies in the diversity and extensive geographic reach, spanning 25 countries across five continents, fostering a dynamic community of knowledge and expertise. The Pasteur Network is recognized as a WHO non-state actor, and members of the network are frequently embedded into local Ministries of Health. The Pasteur Network sustains a global infrastructure encompassing 50+ national and regional reference laboratories, which includes multiple Biosafety Level 3 Laboratories, and 17 WHO Collaborating Centers.

The Pasteur Network's work is guided by four strategic pillars: 1) Epidemic Preparedness, Intelligence, with focus on Climate sensitive diseases, 2) Research, Development, and Innovation, 3) Knowledge Communities, and 4) Good Governance and Equity.

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Pasteur Fiocruz Center on Immunology and Immunotherapy is inaugurated in Cear - Fiocruz

Hospitals with higher ratio of female surgeons, anaesthetists have better patient outcomes: Study – University of Toronto

Greater sex diversity in hospital anaesthesia-surgery teams is associated with better post-operative outcomes for patients, according to a study fromICES,Sunnybrook Research Instituteand the University of Toronto.

The study, published in theBritish Journal of Surgery, found that teams with more than 35 per cent female anesthesiologists and surgeons were associated with a three per cent reduction in odds of post-operative complications in the three months following surgery.

This is one of the first studies to focus on sex diversity of operating room teams, building on past work that has compared the impact of individual surgeon and anesthesiologist characteristics on patient outcomes.

We wanted to challenge the binary approach of comparing female and male clinicians and rather highlight the importance of diversity as a team asset or bonus in enhancing quality care, sayslead authorJulie Hallet, a scientist with ICES and Sunnybrook Research Institute, and associate professor ofsurgeryat U of Ts Temerty Faculty of Medicine.

The study includes population-based, health-care data on 709,899 adult patients undergoing major in-patient surgeries in Ontario between 2009 and 2019.

Sex diversity of surgical teams was defined as the percentage of female anesthesiologists and surgeons among all anesthesiologists and surgeons working in the hospital each year. The primary outcome was 90-day major morbidity, which the researchers analyzed with a standardized classification scale to identify severe post-surgical complications.

The findings showed that reaching a critical mass of more than 35 per cent female anesthesiologists and surgeons was linked to lower odds of severe complications.

The association between greater sex diversity and reduced post-surgical complications was even greater for patients treated by female anesthesiologists and female surgeons which aligns with previous studies comparing outcomes of male to female surgeons.

These results are the start of an important shift in understanding the way in which diversity contributes to better quality care around the time of surgery, says Hallet. Ensuring a critical mass of female anesthesiologists and surgeons in operative teams is crucial to performance. Below a critical mass, female clinicians may withhold their perspectives, such that the benefits of diversity can only be achieved once minimum representation is reached.

One limitation of the study is that the data did not include gender as a social construct. It is possible that gender roles, behaviours and attitudes would have influenced the strength of the association.

The studys authors noted further research is also needed to explore diversity based on other sociodemographic variables, including but not limited to race and ethnicity.

Nevertheless, this study is the first to show a robust positive association between team sex diversity, patient outcomes and quality care.

We hope that these results will encourage hospitals to intentionally foster sex diversity in operating room teams to reduce poor health outcomes, which, in turn, can improve patient satisfaction and promote sustainability of health systems,saysGianni Lorello, staff anesthesiologist atToronto Western Hospital, University Health Network and an associate professor in Temerty Medicinesdepartment of anesthesiology and pain medicine.

Ensuring sex diversity in operative teams will require intentional effort for recruitment and retainment policies for female physicians, structural interventions such as minimum representation on teams, and monitoring and reporting of teams composition to build institutional accountability in existing systems. The research was supported by the Sunnybrook Alternate Funding Plan Innovation Fund.

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Hospitals with higher ratio of female surgeons, anaesthetists have better patient outcomes: Study - University of Toronto

NBC Is Using Animals To Push The LGBT Agenda. Here Are 5 Abhorrent Animal Behaviors Humans Shouldn’t Emulate – The Daily Wire

Caution: The following article contains graphic descriptions of disturbing animal-on-animal violence and sexual deviancy.

In an apparent response to the common argument that the LGBT spectrum of sexualities isnt natural, NBC is showcasing the unorthodox sexual proclivities of the lower life forms in a stunning and brave new documentary titled Queer Planet.

The documentarys trailer, which was posted publicly on X, opens with a shot of a male lion sexually mounting another male, and clips of various presumably same-sex animals nuzzling each other are interspersed with soundbites from expert scientists assuring you that everything you were told as a kid is wrong, this is a queer planet, and its only in humans that we have such a stigma about it.

If you have the stomach for it, take a look at the full trailer below:

Weve all heard of gay penguins, but this film really opened my eyes to the full spectrum of LGBTQ+ behaviors across the natural world, narrator Andrew Rannells said in a press statement. And what could be more natural than being who you are? Im excited to be part of Queer Planet, especially during Pride Month, and on Peacock, surely the most colorful and glamorous of all the streaming services.

The specials official synopsis claims its an exploration of the rich diversity of animal sexuality from flamboyant flamingos to pansexual primates, sex-changing clownfish to multi-gendered mushrooms and everything in between. This documentary looks at extraordinary creatures, witnesses amazing behaviors, and introduces the scientists questioning the traditional concept of whats natural when it comes to sex and gender.

Of course, there are numerous questions surrounding the findings of the documentary and whether homosexual behavior in the animal kingdom really is natural, but the implication of using animal behavior as a justification for similar human behavior may be even more insidious.

Since NBC apparently wants you to believe that something is morally justifiable just because animals do it, here is a non-exhaustive list of some reprehensible things that, according to Queer Planets logic, should be permissible because they are widely practiced in the animal kingdom.

Infanticide within the animal kingdom is extremely common. It is most often practiced by males as part of their reproductive strategy.

For example, when a male liontakes overan established pride, he will often kill any existing young in the group to extinguish the bloodline of the previous dominant male. The loss of the cubs also makes lionesses reenter heat more quickly, allowing the new male to reproduce and pass on his genes in his new pride. Male bears and other mammals such as dolphins and baboons have exhibited the same behavior.

Males committed infanticide more frequently in species where males and females lived together and a few males dominated as mates but only remained at the top of the pack for brief periods of time. The practice was also associated with non-annual or seasonal reproduction cycles, meaning females could mate whenever. Through infanticide, males can eliminate the offspring of their competition and get the female back to full baby-making capacity faster, Smithsonian Magazine noted.

The Smithsonian also noted that mothers will also abandon offspring that are ill and may alsokillthe offspring of other females to cut down on competition if food is scarce.

Cannibalism is also a common occurrence among animals when food is scarce. In cases of drought and famine, many carnivores will feed on the dead bodies of their own species, including their own young.

Certain species of sharks give birth to live young instead of laying eggs like the vast majority of fish do. Those young developing in their mothers womb are often conscious and are able to move about freely. These shark pupswill eateach other while still inside their mother if her nutritious yolk is depleted. This form of cannibalism is so common in the sand tiger shark that a female usually only gives birth to two pups at a time because they have eaten all of their other siblings in the womb.

Many female insects will cannibalize their mates soon after the act of reproduction in order to gain additional nutrients for their eggs. The female praying mantis will infamouslydevourher mate once theyve coupled, usually starting with the head, in order to provide a boost of nutrients to her fertilized eggs. Similarly, black widow spiders often live up to their name bykilling and eatingmuch smaller males after theyve been impregnated.

Mammals like lions, macaques, and leopards have also been knownto engagein cannibalism. Mothers will often cannibalize their dead young in order to recoup nutrients.

Violence akin to what we would consider torture has been observed in a select few animal species, mostly concentrated among those with a high degree of intelligence.

Felines, dolphins, killer whales, and primates have all been observed toying with their prey before killing them.

Many people who have owned cats have seen them play with small birds, rodents, or reptiles before finally killing them. Dolphins and killer whales often exhibit similar behavior with seals and fish.

Chimps will often attack strategic points on an enemys body, most commonly the hands and genitals, to maim them before killing them. Theyve also been observed desecrating the dead bodies of adversaries. One notable instance saw a troop of chimps kill a former leader who had been ejected from the group. They then spent hours eating and mutilating his dead body.

Coerced sexual activity occurs on a fairly regular basis in the animal kingdom. Harassment and intimidation by males are common occurrences among dozens of species.

Rape is a normal reproductive strategy in mallards, Dutch scientist Kees Moeliker told The Guardian in 2005. He observed that male ducks would often chase female ducks and force them to land in order to initiate sexual activity with them.

Instances of sexual coercion by male grey seals in the North Sea were so violent that they resulted in the deaths of several female harbor seals, according to a paper published in 2020. Male dolphins off the coast of Australia work together to isolate a single female and then force copulation.

Sexually coercive behavior has also been documented in chimpanzees and orangutans. Its been theorized that female bonobos create alliances with each other to discourage sexual aggression from males.

Several instances have been observed of animals attempting to mate with the corpses of members of their own species.

Cases of both heterosexual and homosexual acts of necrophilia have beenreported among ducks. Moeliker first observed necrophilic behavior in mallards in 1995. He saw a male mallard die after it flew directly into a window and reportedthat another male attempted to mate with the corpse continuously for almost 75 minutes.

In 2014, scientists in Japan reported that three male sand martin birds attempted to mate with the corpse of another male. A herpetologist witnessedtwo male white and black tegu lizards from Brazil try to mate with a dead female in 2013.

Scientists set upa camera trap near the corpse of a female stump-tailed macaque (a type of monkey) in Thailand, and over three days of observation three different male macaques attempted to have intercourse with the dead female.

Penguins have become one of the mascots of the LGBT animal movement, largely due to several high-profile instances of male penguins forming bonded pairs. A childrens book depicting the same-sex romance between two chinstrap penguins at the Central Park Zoo won multiple awards when it was released in 2005.

However, these birds run the gamut on deviant sexual behavior.

In 1912, a British naturalist who joined Robert Scotts famous Terra Nova expedition to Antarctica described the astonishing depravity of the local Adlie penguins. Calling them little knots of hooligans, the naturalist observed instances of rape, necrophilia, infanticide, and abuse of chicks. He also noted instances of homosexuality.

The preceding account may seem a little morbid, even brutal, but it illustrates the danger in justifying certain human behaviors by pointing to similar behavior in animals. Though it can often look idyllic in documentaries or during a casual stroll in a park, morality is often absent in the natural world, and humans ability to discern it is one of our primary advantages over animals.

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NBC Is Using Animals To Push The LGBT Agenda. Here Are 5 Abhorrent Animal Behaviors Humans Shouldn't Emulate - The Daily Wire

32 animals that act weirdly human sometimes – Livescience.com

Humans often think we are unique, with abilities and behaviors far more complex than our distant animal cousins. But in fact, many creatures, from tiny insects to our closest living relatives, exhibit a surprising repertoire of behaviors that can seem eerily human. From elephants mourning their dead to bees that get pessimistic when faced with setbacks, here are some of the most human-like behaviors demonstrated by other members of the animal kingdom.

Chimpanzees (Pan troglodytes), along with bonobos, are our closest living relatives. A 2018 study found that chimpanzees not only share the same five major personality traits with humans conscientiousness, openness, agreeableness, extraversion and neuroticism but that these traits could be linked to life span. Scientists found that more agreeable male chimpanzees formed stronger social bonds and tended to live longer.

A separate 2020 study published in the journal Science found evidence of social selection in aging male chimpanzees, with individuals showing a preference for more meaningful social interactions with older friends in a smaller group. This is similar to aging human adults, who tend to choose lifelong friends and socialize in smaller groups than in our youth, the study noted. Another study showed that chimpanzees, much like young children, copy human behaviors such as waving, clapping and kissing. And like humans, chimps also "wage war" to expand their territory.

The gorilla is another large primate that exhibits human-like traits. Scientists have found evidence of gorillas displaying the five human-like personality traits in both the wild and captivity. They use facial expressions and gestures to communicate, and feel joy, empathy and sadness. A 2016 study of gorilla behavior even found personality variations among different gorilla populations. And cultural traits a largely human behavior varied among five groups of gorillas, including mountain gorillas (Gorilla beringei beringei) and western lowland gorillas (Gorilla gorilla gorilla), in different African habitats.

Dolphins are known for their intelligence and sociability, and a 2021 study found that, similar to humans and other primates, bottlenose dolphins (Tursiops truncatus) have the personality traits of openness, sociability and disagreeableness. Interestingly, researchers also identified a fourth personality trait, dubbed directedness, which is unique to dolphins and combines elements of low neuroticism and conscientiousness.

"Throughout our lifetime, we interact and form relationships with a wide variety of people dolphins do the same with each other," Blake Morton, a lecturer in psychology at the University of Hull in the U.K., said in a statement. "Collectively, being smart and social,regardless of what ecosystem you live in, may play an important role in the evolution of certain personality traits."

With their huge brains, high intelligence, strong social bonds and empathetic behavior, Asian elephants (Elephas maximus) display many human-like traits, including facial recognition. In 2006, researchers found that, like humans, elephants recognize themselves in a mirror, and in 2015, a separate research team found that elephants have incredible long-term memories.

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A 2009 study found evolutionary evidence that genes that affect brain function, energy usage and metabolism, have evolved similarly in large-brained mammals such as elephants and humans. A separate 2023 study found that, like humans, elephants have followed an evolutionary process of domesticating themselves, in which their cultural and societal structures helped increase sociability and reduce aggression in creatures over time.

Like humans, magpies, a member of the crow or corvid family, can make and use tools to feed their young and mimic human voices. Another study also found evidence that European magpies (Pica pica) recognize themselves in a mirror.

Sometimes nicknamed "feathered apes" because their cognitive ability has been found to rival that of nonhuman) primates, Eurasian jays (Garrulus glandarius) are also members of the corvid family. They can learn how to use tools and demonstrate an extraordinary level of self-restraint. A 2022 study found that Eurasian jays possess self-control. In that research, scientists found that Eurasian jays could pass an avian version of the "marshmallow test" they could withhold the temptation to eat mealworms right away. The scientists found that the jays with the most self-control scored the highest on intelligence tests.

Orcas (Orcinus orca), also known as killer whales, form strong social bonds and live in close-knit family groups called pods. Orcas have been recorded hunting, sharing food, communicating and socializing within their pod, demonstrating advanced cultural and personality traits. While studying the behavior of 24 captive orcas, researchers found that, like humans and chimpanzees, orcas have the personality trait of extraversion, as demonstrated by their playfulness and affection. Further research has found that captivity can change orcas' behavior, increasing their aggression and neuroticism.

A 2011 study found that rats display prosocial behavior. In that research, scientists recorded evidence of rats helping one another by allowing one rat to roam freely while another was trapped in a container. It appeared that the free rat shared the emotional distress of the trapped rat, despite no reward being offered each time it willingly freed the captive rat. However, a 2014 study suggested that it was a desire for social contact, rather than empathy, that encouraged the rat to rescue the captive rat.

In a much earlier experiment in 1958, researchers allowed rats to feed only if they pulled a lever that shocked fellow rats. The rats refused to do so, which, according to the researchers, indicated empathy and compassion.

In a 2018 study published in the journal Learning and Behavior, researchers found that dogs (Canis lupus familiaris) notice when people are in distress and seek to comfort them a behavior the researchers interpreted as evidence of empathy.

In the experiment, dog owners cried or hummed behind a closed door. The dogs that suppressed their own stress reaction in order to comfort the humans opened the door the fastest.

Male mountain bluebirds (Sialia currucoides) seem to get jealous when spurned in mating, according to a 1975 study published in the journal The American Naturalist. Researchers found that when a male bluebird leaves the nest to forage, its female partner may move on with another male. In response, the male bluebird was found to savagely beat their partner by pulling out feathers and snapping beaks.

Like humans, horses (Equus caballus) can interpret facial expressions and distinguish human emotions. Similarly to dogs, horses are known for having close relationships with their owners.

In a 2018 study, the researchers found that horses cross-modally recognized the voices, facial expressions and emotional states of their primary carers and strangers. "Our study could contribute to the understanding of how humans and companion animals send and receive emotional signals to deepen our relationships, which could help establish a better relationship that emphasizes the well-being of animals," Ayaka Takimoto, an associate professor at Hokkaido University in Japan and co-author of the study, said in a statement.

Don't be fooled by their cute and fluffy appearance; female meerkats (Suricata suricatta) will kill any female rivals. Nonetheless, meerkats do exhibit a more caring side, with adults taking turns babysitting young meerkats and spending time educating them in essential life skills. This human-like child-rearing behavior has a strong evolutionary motivation, as it allows the dominant female meerkat to devote her time to breeding.

As part of a three-year study launched in 2023, researchers are investigating whether meerkats mirror human emotion and display empathy, with the aim of better understating human-animal interactions.

Although cats don't adore us in the intense way dogs do, a 2021 study found that they are capable of forming bonds with humans depending on the emotional behavior of the owner. A 2020 study also found evidence that cats (Felis catus) released the "bonding" hormone oxytocin when stroked, although to a much lesser degree than dogs.

However, when it came to displaying complex human-like emotions, jealousy was more commonly seen in cats than empathy or compassion, according to a 2016 study.

Pigeons have been shown to understand dozens of human words. And a 2016 study found that a pigeon could distinguish up to 60 words, marking the first time a nonprimate could recognize letters and have an orthographical brain, meaning they can process and understand letters.

According to study lead author Damian Scarf, an associate professor of psychology at the University of Otago in New Zealand, the findings provided more insight into human brain development and our cognitive skills. "If you find something like this with pigeons, you can argue that it must've been common to our last common ancestor with pigeons, which is about 300 million years ago," Scarf said in a statement. "So the same flexibility and plasticity of the human brain that lets us pick up on words and the statistics behind them must've been present when we were still joined with pigeons."

Like humans, dragonflies can shut out unnecessary information, enabling them to focus on a specific task. This behavioral trait is seen in primates, which have a limited amount of attention and thus must choose between focusing in depth on a single task or multitasking with less focus.

In 2012, scientists found evidence that dragonflies have "human-like" selective attention when hunting their prey. Using a microscopic sensor in a dragonfly's brain, they found that this brain activity, known as neural filtering, enabled the insect to successfully capture their prey 97% of the time.

Scientists have found that, like humans, honeybees feel more pessimistic after a stressful experience.

In a 2011 study, bees were offered sugar or quinine, with a mix of odors, before being shaken in a way that stimulated a predator attack. The shaken bees had lower levels of the feel-good hormones dopamine and serotonin, suggesting they might experience some negative human-like emotions, according to the researchers.

Although they're not commonly associated with cleanliness, cockroaches have a preference for self-hygiene and groom themselves incessantly.

According to a 2013 study, cockroaches (Periplaneta americana) do this to keep their antennae working efficiently, as a buildup of environmental pollutants and their own waxy secretions harm their ability to smell pheromones to find a mate, source food and sense danger.

"The evidence is strong: Grooming is necessary to keep these foreign and native substances at a particular level," Coby Schal, an entomologist at North Carolina State University and co-author of the study, said in a statement. "Leaving antennae dirty essentially blinds insects to their environment."

Other than when they mate, Snakes are generally known for being solitary. But a 2023 study published in the journal Frontiers in Ethology found that, like humans, snakes may comfort one another in periods of stress. When adult southern Pacific rattlesnakes (Crotalus helleri) in the study experienced a stressful situation with another snake of the same species, they had a lower heart rate than a snake that had not experienced such an encounter.

Facial recognition is essential to forming complex social connections. Humans as young as 2 months have mastered this skill.

Unlike primates, fish lack a large brain and visual cortex that aids in processing images. Yet archerfish can recognize human faces. In a 2016 study, scientists found that archerfish could learn and recognize human faces with accuracy.

"The fact that archerfish can learn this task suggests that complicated brains are not necessarily needed to recognise human faces," Cait Newport, a researcher in the University of Oxford Department of Zoology and first author of the study, said in a statement.

While studying Japanese macaques (Macaca fuscata) in 2024, scientists found that nerve cells in the brain's premotor cortex, which prepares and executes movement in the limbs, strongly responded when tasked with adding and subtracting.

And back in 2008, a group of captive Japanese macaques were trained to use tools, with scientists finding cognitive similarities with humans. A 2021 study found that Japanese macaques can respond to the human gaze flexibly depending on the context, indicating a high level of perspective of others and their intent.

Along with chimpanzees, bonobos (Pan paniscus) are humans' closest living relatives. Known for living peacefully in close-knit social groups, bonobos engage in sex with both sexes, by touching genitals to greet each other and to deescalate violence.

According to a 2022 study, bonobos, like humans, can form harmonious relationships outside their immediate group by helping those in need. However, it appears their social interactions may not be completely harmonious, with a 2024 study finding evidence of aggression between male bonobos.

Whales use song to form social groups, find a mate and communicate. Much like humans, their taste in music evolves over time, with each whale species creating their own song. A 2017 study into cetacean culture and behavior found that, like humans, whales and dolphins of various species live in tight-knit social groups, form mutually beneficial alliances and enjoy playing. Scientists attribute much of whales' social behavior to their large brains.

Female Northern mockingbirds (Mimus polyglottos) can not only distinguish familiar humans but also judge which individual poses the greatest threat, allowing them to flee from their nest to safety, a 2023 study found. This finding suggests these birds have higher cognitive ability than scientists previously thought.

This research adds to findings from a 2009 study showing that wild mockingbirds don't forget people and have been found to chase away familiar humans they perceive as threatening.

Scientists have found that big cats including cheetahs (Acinonyx jubatus), lions and tigers can recognize human voices and distinguish them from those of strangers. The 2024 study found that these cats reacted more quickly and more intensely to human voices they recognized. The study authors said the findings indicate that less-social feline species can still have socio-cognitive abilities.

A separate 2018 study of captive and wild cheetahs found that they not only recognized human voices but also discriminated between caregivers and strangers and changed their activity in response. Wild cheetahs also appeared to recognize human voices, potentially because they lived in close proximity to humans.

With their blue blood and multiple brains and hearts, octopuses may seem otherworldly. However, they are also known for being highly intelligent, with strong facial recognition and learning abilities. A 2010 study found that giant Pacific octopuses (Enteroctopus dofleini) could recognize individuals using their large orbital lobes, an area of the brain used for vision. Researchers found that these octopuses were picky about who they liked and disliked, with each octopus showing a strong preference for the keeper who fed it.

Octopuses are also the only known marine invertebrate that can use tools, thanks to their long arms, each of which contains a brain.

Parrots not only have the extraordinary ability to mimic human speech but also exhibit social complexity and, like humans, use memories of past actions to influence future behavior. A 2022 study found that blue-throated macaws (Ara glaucogularis) demonstrated mental self-representation and episodic memory.

In 2020, an African gray parrot named "Griffin" (Psittacus erithacus) outperformed Harvard students in a memory-test game. According to the researchers, both the parrot and humans used a part of their working memories known as manipulation to remember and manipulate information, suggesting a similar ancient evolutionary capability.

Research shows that some penguins communicate by "singing" and can adapt their behavior to their environment. For example, Emperor penguins (Aptenodytes forsteri) huddle together for warmth.

Penguins are complex social creatures that, like humans, rely on collaborative social skills to problem-solve for tasks such as hunting.

A 2021 study found that African penguins (Spheniscus demersus) could recognize an individual by matching their appearance to their voice, and a 1999 study found that a penguin could identify its mate's voice in a crowd.

Tamarin monkeys small, orange primates that live in South and Central America display several behaviors that could be considered human-like. In a 2013 study, scientists found evidence of cotton-top tamarins (Saguinus oedipus) "whispering" to one another when in the presence of a human they disliked.

Ants are highly intelligent insects that live in huge colonies and form complex social structures. Like humans, ants teach one another new skills, a 2006 study found. Scientists observed ants performing a "tandem-running" style of teaching, with one ant showing another the route to a food source.

According to researchers, this indicates that teaching can evolve in animals with small brains. Even though the tandem leader doesn't immediately benefit, the tandem follower was found to quickly learn and show others, ultimately benefiting the entire colony.

Crickets are another insect with impressive memory skills. A 2006 study found that crickets of the species Gryllus bimaculatus could remember seven odors at a time and, like humans, have long-term memory. In a 2022 study, researchers found that crickets could learn and remember food sources using odors.

In 2011, scientists found that, like caring humans, crickets often put the needs of their mate before their own.

"Relationships between crickets are rather different from what we'd all assumed," Rolando Rodrguez-Muozof, a researcher at the University of Exeter in the U.K. and co-author of the study, said in a statement. "Rather than being bullied by their mates, it seems that females are in fact being protected. We could even describe males as 'chivalrous.'"

Like humans, orangutans are social primates with opposable thumbs, which they use to grasp things and swing through the trees.

Also like humans, orangutans (Pongo) can learn their own "languages" and often communicate using body language. A 2018 study found evidence that orangutans can "talk" about the past. Researchers observed female orangutans warning their young of past dangers in a form of language known as "displaced reference," providing insight into how vocal systems have evolved in humans.

Crows are highly intelligent birds with complex brains that allow them to solve problems and use tools to their advantage. A 2019 study found evidence of New Caledonian crows (Corvus moneduloides) using a hooked tool to forage plants.

Like humans, crows also possess self-awareness and can make decisions. A 2020 study published in the journal Science showed that crows use sense and reason to problem-solve, and a 2017 study found that crows rival some primates in intelligence.

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32 animals that act weirdly human sometimes - Livescience.com