NEW YORK (GenomeWeb) Cancer Genetics reported today that its fourth quarter revenues grew 32 percent year over year.
For the three months ended Dec. 31, 2016, the company reported revenues of $7.2 million up from $5.5 million in Q4 2015.
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Cancer Genetics Q4 Revenues Up 32 Percent - GenomeWeb
Dr. Asuncion Fernandes, St. Lukes Medical Centre, Quezon City, PhilippinesDr. Mike Macnamee, MSc, PhD, Chief Executive, Bourn Hall Clinic, Cambridge, UK Lets Do ICSI 03rd - 07th Dec 2007 Shabaan AI-Dahha, HOD Basra Medical College, Basra, Iraq - Lets Do ART, Special Bath 18th Feb - 01st March 2008Dr. Dandapani Banerjee, Kolkata, India Dr. Alka Sen, Sen Maternity & Eye Hospital (P) Ltd, Agra, IndiaDr. Asheesh Gude, Sinai Fertility Center, Margo, Goa, India. Dr. Sanjukta Saha, Moulana Bhasani Medical College, Dhaka, Bangladesh Dr. Faiz Alwaeely, Asst Professor, Basra Medical College, Basra, IraqDr. Shamima Dawood, Linmed Hospital, Johanesburg, South AfricaA moment of Pride - Bourn Hall Clinic Team with the traineesDr. Sabina Shreshta, Om Hospital, Katmandu, NepalBackground-Dr. Earnest J. Moloi, Medi Clinic, Welkom, South Africa Foreground-Dr. Mohammad Ahmad Maarouf, RomaniaDr. Lucy Coleman, Whiltshire, UK Dr. Sanjay Gandhi,City Gem IVF, Dessa, Gujarat. India.
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Embryology Academy for Research Training
The earliest mutations of human life have been observed by researchers at the Wellcome Trust Sanger Institute and their collaborators. Analysing genomes from adult cells, the scientists could look back in time to reveal how each embryo developed.
Published in Nature, the study shows that from the two-cell stage of the human embryo, one of these cells becomes more dominant than the other and leads to a higher proportion of the adult body.
A longstanding question for researchers has been what happens in the very early human development as this has proved impossible to study directly. Now, researchers have analyzed the whole genome sequences of blood samples (collected from 279 individuals with breast cancer) and discovered 163 mutations that occurred very early in the embryonic development of those people.
Once identified, the researchers used mutations from the first, second and third divisions of the fertilized egg to calculate which proportion of adult cells resulted from each of the first two cells in the embryo. They found that these first two cells contribute differently to the whole body. One cell gives rise to about 70 percent of the adult body tissues, whereas the other cell has a more minor contribution, leading to about 30 percent of the tissues. This skewed contribution continues for some cells in the second and third generation too.
Originally pinpointed in normal blood cells from cancer patients, the researchers then looked for these mutations in cancer samples that had been surgically removed from the patients during treatment. Unlike normal tissues composed of multiple somatic cell clones, a cancer develops from one mutant cell. Therefore, each proposed embryonic mutation should either be present in all of the cancer cells in a tumor, or none of them. This proved to be the case, and by using these cancer samples, the researchers were able to validate that the mutations had originated during early development.
"This is the first time that anyone has seen where mutations arise in the very early human development. It is like finding a needle in a haystack. There are just a handful of these mutations, compared with millions of inherited genetic variations, and finding them allowed us to track what happened during embryogenesis," said Young Seok Ju, first author from the Wellcome Trust Sanger Institute and the Korea Advanced Institute of Science and Technology (KAIST).
"Having identified the mutations, we were able to use statistical analysis to better understand cell dynamics during embryo development. We determined the relative contribution of the first embryonic cells to the adult blood cell pool and found one dominant cell - that led to 70 percent of the blood cells - and one minor cell. We also sequenced normal lymph and breast cells, and the results suggested that the dominant cell also contributes to these other tissues at a similar level. This opens an unprecedented window into the earliest stages of human development," said Inigo Martincorena, from the Sanger Institute.
During this study, the researchers were also able to measure the rate of mutation in early human development for the first time, up to three generations of cell division. Previous researchers had estimated one mutation per cell division, but this study measured three mutations for each cell doubling, in every daughter cell.
Mutations during the development of the embryo occur by two processes - known as mutational signatures 1 and 5. These mutations are fairly randomly distributed through the genome, and the vast majority of them will not affect the developing embryo. However, a mutation that occurs in an important gene can lead to disease such as developmental disorders.
"This is a significant step forward in widening the range of biological insights that can be extracted using genome sequences and mutations. Essentially, the mutations are archaeological traces of embryonic development left in our adult tissues, so if we can find and interpret them, we can understand human embryology better. This is just one early insight into human development, with hopefully many more to come in the future," said Mike Stratton, lead author on the paper and director of the Sanger Institute.
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First Mutations in Human Life Discovered - Laboratory Equipment - Laboratory Equipment
The report Global Biochemistry Analyzers Market 2017 is a professional, in-depth study that includes insights extracted from complex information, which clients can use for their business advantage. A large volume of precise, reliable market data has been distilled into clear and actionable insight for clients so that they can formulate their plans or make crucial business decisions with precision.
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Analysis also covers upstream raw materials, equipment, downstream client survey, marketing channels, industry development trend and proposals. In the end, the report includes Biochemistry Analyzers new project SWOT analysis, investment feasibility analysis, investment return analysis, and development trend analysis. In conclusion, it is a deep research report on Global Biochemistry Analyzers industry. Here, we express our thanks for the support and assistance from Biochemistry Analyzers industry chain related technical experts and marketing engineers during Research Teams survey and interviews.
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Global Biochemistry Analyzers Market Forecast Research Report 2017 2021 - GreaterPatchogueDaily
A censored 16th century anatomy book may provide evidence that taboos slowed the development of knowledge of the female genitals, researchers have said.
The 1559 edition of Thomas Gemini's Compediosa Totius Anatomie Delineatio features a depiction of a semi-dissected female torso, and the book's original owner has cut away a neat triangle of paper on which the vagina would have been drawn.
It will be displayed in an exhibition at St John's College at the University of Cambridge, and curator Shelley Hughes said it may offer clues as to why knowledge of the female anatomy lagged behind that of the human body as a whole.
She said the book's original owner was disturbed by its depiction of a semi-dissected female torso.We know this because the offending part, a neat triangle of paper on which the vagina would have been drawn, has been carefully cut away.
She added: Sin and female flesh were held in close association in 16th century society with naked women often portrayed as the servants of Satan.Perhaps Christian Europe would have to overcome its shame over the female reproductive organs in order to discover more about their structure.
Before the 16th century, many European academics believed that female genital organs were simply lesser versions of male organs, turned inside out.
This dated back to classical medical authorities such as Galen in the 2nd century, who had been prohibited by law in Ancient Rome from cutting up human corpses.
The 16th century was a time of medical revolution, with pioneering researchers such as Andreas Vesalius challenging accepted views on anatomy, with evidence gathered from human dissections and direct observation experiment.
But there was still a reluctance to take on some foundational beliefs in science.
The display shows how an evidence-based knowledge of the structure of the body emerged as superstitious and religious barriers weakened.
The exhibition, to be displayed on Saturday, is called Under The Knife At St John's: A Medical History Of Disease And Dissection
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Censored 16th century anatomy textbook could be root of vagina taboo - The Independent
Poor Maggie Piercehas no idea what she's about to be hit with.
With Grey's Anatomy returning to Grey Sloan Memorial after last week's sojourn to Montana for a little Japril action, the focus will turn to the young cardiothoracic doc thanks to a return visit from her mom Diane (LaTanya Richardson Jackson), who's back to treat the breast cancer she's still hiding from her daughter. Oh, and there's the small matter of that growing attraction between Meredith (Ellen Pompeo) and the object of Maggie's affection, Riggs (Martin Henderson), finally coming to the forefront.
E! News caught up with Kelly McCreary on the red carpet at the long-running ABC series' PaleyFest event, where she gave us some insight into how the surgeon will handle her world basically falling apart at the seams.
ABC
"I think, first and foremost, Maggie is the brightest person she knows," McCreary told us about the urgent matter to save her mom's life. "And she's going to try to solve her problems herself. And of course, when you try to do everything yourself, you get tuckered out." We've got a feeling that Jackson (Jesse Williams), Diane's chosen doctor and the reason she came to Seattle for treatment, is going to have something to say about that.
And as for the small matter of her half-sister taking up with her crush?"It's a bad idea to keep secrets. Just don't do it," she joked. "I don't think the audience is going to get the reaction that they're expecting out of Maggie. Let's put it that way."
Elsewhere in the episode, Owen (Kevin McKidd) and Amelia (Caterina Scorsone) finally hash out their problems as they work a trauma case together, while Bailey (Chandra Wilson) tries to mend her relationship with Richard (James Pickens Jr.) after, you know, stabbing him in the back and taking the Residency program away from him. Good luck with that, Bailey!
For more from McCreary, be sure to check out the video above.
What sort of unexpected reaction do you think Maggie will have to the Mer-Riggs relationship? Share your theories in the comments below!
Grey's Anatomy airs Thursdays at 8 p.m. on ABC.
E! Online - Your source for entertainment news, celebrities, celeb news, and celebrity gossip. Check out the hottest fashion, photos, movies and TV shows!
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Grey's Anatomy's Kelly McCreary Teases Maggie's Double Dose of Drama Ahead - E! Online
We love Shonda Rhimes. As far as we're concerned, every year is a Year of Yes. But when a star of not one but two of the prolific showrunner's series decides to willingly spill some tea about Shonda, of course we're going to be all ears.
That's exactly what Grey's Anatomy and Private Practice star Kate Walsh did when she appeared on Watch What Happens Live with Andy Cohen Wednesday night as she answered questions posed by the Shady Shonda Anaconda who slithered onto the screen.
Though Shonda is legendary for her gift giving, not every present has been a winner. "We once got, I think, just a box of potpourri," Kate said on WWHL. "We were like, 'Really? We just won every award known to man. That's cool. That's super cool.'"
Kate also revealed that she thought Grey's Anatomy jumped the shark during "the bomb episode," the Season 2 episode entitled "As We Know It." "But that's the one that made it everything, that made Grey's Anatomy," Kate explained. "I'd say she jumped that shark, but then we rode it all the way to the top."
So did Shonda ever throw any shade of her own? "Here's what I will say, we had on Private Practice, all I'll say is there was a no a-hole policy," Kate replied. "How about that?"
We guess we'll take it.
Watch Kate and her fellow WWHL guest Laura Dern spill some more Hollywood secrets, below.
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Kate Walsh Let the Shade Fly About Shonda Rhimes and Grey's Anatomy - Bravo (blog)
Playing Ellen Pompeo on Her Greys Anatomy Directorial Debut and Hiring a Baby Nurse: Id Be Nowhere Without Her
Ellen Pompeo is dishing on the secret to juggling motherhood with a busy career, which comes to a head with her upcoming Greys Anatomy directorial debut -- nurse Jackie!
The 47-year-old mom-of-three stopped by The Ellen DeGeneres Show, where her 5-month-old son, Eli, waited backstage.
WATCH: Ellen Pompeo Shares Boy Crazy Video Dancing With Infant Son
He is the sweetest thing ever so adorable, Pompeo gushed, before adding that the tot is now sleeping through the night. He is. I have the most fantastic baby nurse, Jackie, whos also backstage -- Hi Jackie!
She helps me and Id be nowhere without her because I work long days and I need help caring for him, she continued. Shes got my back -- and his. Its funny because everyone who meets her is like, I want Jackie! and Im like, You dont have a baby. [Theyre like], Yeah, I know but I just want Jackie!
Photo: Michael Rozman/Warner Bros
Long days at work are nothing new for the Greys veteran, but shes been even busier than usual on set lately, due to directing her first episode of the ABC series.
Titled Be Still, My Soul, the episode airs on March 30, and Pompeo said she had a blast behind the camera.
I definitely had an advantage being there for 13 seasons, says Pompeo, whose Ellen appearance airs on March 23. It was super fun. [Executive producer] Debbie Allen really wasnt going to take no for an answer and enough women dont get the opportunity to direct, so I thought, Who am I to get the opportunity and say no?
EXCLUSIVE: Greys Anatomy Star Justin Chambers on a Meredith-Alex Romance
If work and kids arent enough to keep her busy, Pompeo also added to the familys brood by adopting another dog recently.
[I now have] four dogs, four chickens and a fish, she shared. Oh, and a husband too.
We adopted Lily from Love Leo Rescue, she said of the new addition. I was scared for her when she first came because she was scared. Every time someone would come in the house she would run and hide under a bed. Ive worked with her a lot to get her to the place where she is comfortable and she has made the most amazing progress. Shes a completely different dog.
See what Pompeos castmate, Justin Chambers, had to say about a possible Alex-Meredith romance on the show in the video below.
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Ellen Pompeo on Her 'Grey's Anatomy' Directorial Debut and Hiring a Baby Nurse: 'I'd Be Nowhere Without Her' - Entertainment Tonight
Fowlkes, 26, was suspended from her job as an anatomy and physiology teacher at Lockhart High School after turning herself in to police Monday hours after celebrating her birthday with her hubby.
WNDs Big List of female teachers with students: Most comprehensive account on Internet of women predators on campus
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Anatomy teacher all smiles after student-sex bust - WND.com
Greg Smiths Urban Visions is planning S, an office campus in Seattle that takes into account how office design affects the brain. (NBBJ Rendering)
The ceiling height of an officecan influence whether a team is better at figuring out big picture problems or hashing out complex details. Your focus, stressand energy levels are affected by the presence of green and blue in the office.
These are just a few of the ways that designers are taking into account how the human brain works when designing buildings. NBBJ, which designed Amazons new downtown campus and is doing another Seattle campus project called S, has been workingwith Dr. John Medina, a developmental molecular biologist and professor at the University of Washington. Together, they have delved into the work of numerous neuroscientists to learn how the human brain interacts with the environments people experience all the time, specifically their offices.
Medina, who spoke at CoreNet Global event in Seattle Wednesday still counts himself as a skeptic of the effects of neuroscience and designbecause we still know very little about the human brain.
Our understanding of how (the brain) works is childlike, particularly in relationship to the kinds of questions we are asking about designing buildings, Medina said.
But there are some themes that emerge when looking at the work of prominent neuroscientists, and lessons that designers can take from them.
For the majority of our existence, humanity has existed outside. So its a bit unnatural for us to spend large chunks of our days cooped up inside an office building. To counteract that, designers have done their best to mimic the outdoor environment, with plenty of open space, access to natural light, greenery within the building and fresh air.
But all you open office fans hold on for a second. Medina cites HarvardsEdward O. Wilson, who posited that humans have a constant attraction to open space. Butas soon as things get difficult, whether its a foreboding creature in the wild, or a conference call that is way too loud, people look to retreat and collect themselves. Anyone building out a big open office better make sure to have some quiet places where people can focus.
The bit about ceilings goes back to a concept created by Joan Meyers-Levy of the University of Minnesota called the Cathedral Effect. It states that the height of the ceiling has a bearing on the types of problems people and teams can solve.
Subjects focus on the gist aspects of information, have the least attention to details and solve gist problems best when the ceiling is soaring, Medina said. And they suck at the details. If you want to get them to do the details, lower the ceiling.
No one knows why this Cathedral Effect exists, Medina said, just that it does.
Colors also affect your mood. The color blue is known to send the message to parts of the brain to be alert, according to research from Mariana Figueiro of Rensselaer Polytechnic Institute in New York cited by Medina. Bluesuppresses melatonin, the chemical that helps us fall asleep. And why is that?
In our evolutionary history, the only time we ever saw blue was when we saw the sky, and the only time you can see sky is in the daytime So your brain thinks its the freakin day time.
Green correlates to plants, and we are attracted those, Medina said, because they are nourished by water. It goes to our survival instincts. When we see green, we are more focused and at ease.
So how do these concepts translate to office buildings? NBBJ is designing the big S campus for Seattle developer Greg Smiths Urban Visions. The project is near CenturyLink and Safeco fields and includes six buildings totaling 1.2 million square feet. It is in the permitting process and has just begun looking for tenants.
Smith said the project was designed with a priority of people first, building second. That means the team is trying to build a campus that is healthy and inviting to workers and visitors alike. When it comes to development, the priority has always beenbuilding first, people second.
I think we have just accepted what our spaces do for us, Smith said. We need to demand that our spaces make us happier, more creative and healthier.
The spacing of teams is important and something the S team has been paying attention to. Ryan Mullenix, a partner at NBBJ, said the limit people typically want to walk to go to someone elses desk. Sixty-five feet is email range, and if someone is 100 feet away, he or she might as well be in an entirely different building.
In addition to knowing how the brain reacts to various elements of a building, designers also want to stimulate peoples brains to get them thinking creatively. One way to do that is variety. By making no two common spaces, landscaped areas or offices alike, the mind is awakened by new experiences.
We want to create a bunch of different moments that are unlike any other moment in the project, Mullenix said.
But the best way to keep workers engaged, creative and open to new ideas, according to Medina? Make them learn a brand new language. Hows that for team building?
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The secret science of your office space: How architects are using neuroscience to make workers healthier and more ... - GeekWire