Time Management from a Neuroscience Point of View – Big Think

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Theres probably no one as continually aware of managing their cognitive load than a neuroscientist. Such a person knows that our neural capacity isnt infinite, and is painfully cognizant that every one of those thousand tiny threads we cant let go of as we go about our lives takes up precious bandwidth.

Neuroscientist/musician Daniel Levitin has a few tips for managing your time, with a bonus: The freeing up ones neurons for more enjoyable, productive use. The common theme is the offloading of freight from your head and out into the physical world.

daniel-levitin-on-scheduling-practices

One wonders how just many index cards we need.

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Time Management from a Neuroscience Point of View - Big Think

Immunity: Beyond classical genetics – Nature.com

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Women freeze their eggs as partners get cold feet – The Times (subscription)

Women are freezing their eggs because men are refusing to commit to starting a family, a leading professor has warned.

Joyce Harper, professor of embryology at University College London, says it is wrong to think women freeze their eggs because they are obsessed by climbing the career ladder when, in reality, many are deserted by their partners when the issue of starting a family is raised.

As soon as the women mention Should we start having a family, should we think about it? the men have said, Bye, Harper said.

Unlike female fertility, which declines rapidly after the age of 35, men are able to father children into their fifties and older.

She said: It is easier for the men. They can just delay it

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Women freeze their eggs as partners get cold feet - The Times (subscription)

New Insights into how the Vascular Tree is Formed – Technology Networks

In diseases like cancer, diabetes, rheumatism and stroke, a disorder develops in the blood vessels that exacerbates the condition and obstructs treatment. Researchers at Karolinska Institutet now show how blood vessels can normally change their size to create a functional circulatory system and how vascular malformation during disease can occur. In the study, published in Nature Cell Biology, the researchers managed to treat vascular malformation in mice, a discovery of potential significance to numerous vascular diseases.

A healthy body has a perfect balance of arteries, capillaries and veins that allow the blood to reach every cell in the body and that form what is called the vascular tree. New blood vessels are formed by endothelial cells, which normally coat the inside of blood vessels and which organise themselves into tubes and mature, along with other cells, into arteries, capillaries or veins.

Throughout a persons life, the vascular tree has to adapt its branches to the changing needs of body tissue, such as during growth, muscle building or wound healing. However, there are diseases that affect the endothelial cells in a way that throws the vascular tree out of balance, which exacerbates the disease and often causes haemorrhaging. In cancer, for example, it is known that the vessels leak and direct shunts form between arteries and veins, preventing drugs from reaching the tumour.

To understand how arteries, veins and capillaries are created and how the process malfunctions in the presence of disease the researchers studied normal vascular formation and the inherited Osler-Weber-Rendu disease (HHT), which is characterised by vascular malformation and repeated haemorrhaging, with an increased risk of stroke. By switching signals on and off in the endothelial cells of genetically manipulated mice, the researchers could describe how the protein Endoglin controls vascular formation and malformation. They found that the protein acts like a sensor that detects blood flow and tells the endothelial cells to organise themselves into veins, capillaries or arteries as necessary. Cells that lacked the protein were less able to form arteries.

The researchers were also able to reduce vascular malformation in the genetically manipulated mice.

Our findings contribute to the understanding of fundamental biological processes that explain how the vascular tree is formed and what causes vascular malformation, says Lars Jakobsson, assistant professor at Karolinska Institutets Department of Medical Biochemistry and Biophysics. Drugs with a similar effect as one of those we tested are currently used to treat patients with inherited vascular malformation but are still under evaluation. Now we have another candidate and a more nuanced idea of how it works. We are now in a better position to control the formation and malformation of blood vessels and thus their function, which can eventually lead to improved treatments for a number of diseases.

The researchers at Karolinska Institutet also contributed to a parallel study, published in the same issue of Nature Cell Biology, describing how blood flow influences endothelial cell size that in turn affects vessel identity and malformation.

This article has been republished frommaterialsprovided byKarolinska Institutet. Note: material may have been edited for length and content. For further information, please contact the cited source.

Publications

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling. Yi Jin, LarsMuhl, Mikhail Burmakin, YixinWang, Anne-Claire Duchez, Christer Betsholtz, Helen M. Arthur and Lars Jakobsson. Nature Cell Biology, online 22 May 2017

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Wade W. Sugden, RobertMeissner, Tinri Aegerter-Wilmsen, Roman Tsaryk, Elvin V. Leonard, Jeroen Bussmann, Mailin J. Hamm, Wiebke Herzog, Yi Jin, Lars Jakobsson, Cornelia Denz, Arndt F. Siekmann. Nature Cell Biology, online 22 May 2017

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New Insights into how the Vascular Tree is Formed - Technology Networks

The anatomy of caliphate colonialism (2) – Vanguard

By Douglas Anele

Unfortunately, but not surprisingly, the dominant political parties that emerged in Nigeria before independence and played prominent roles in defining the direction of her future political evolution were largely regional parties. For instance, in northern Nigeria, the political landscape was dominated by the Northern Peoples Congress (NPC), whose catchphrase One North, One People, accurately encapsulates its core agenda.

It was unabashedly a political organisation specifically set up to cater for the concerns of northern region alone, particularly the interests of the domineering feudalist conservative elite, to the extent that it refused to present candidates for elections in the south. Interestingly, NPC leaders were surprised that its gesture of separateness was not reciprocated by political parties in the south.

Consequently, they strongly resisted efforts by parties in southern Nigeria to field candidates in the north, which Balewa saw as appropriate to response to the invasion of northern region by southerners, and considered southern politicians campaigning in northern Nigeria an unwelcome challenge to norths territorial sovereignty. Action Group (AG) was the major party in western Nigeria, whereas the first truly national political party was the National Council of Nigeria and the Cameroons (NCNC), although it eventually mutated into a regional party called the National Council of Nigerian Citizens dominated by the Igbo.

Given this tripartite regional political configuration, two scenarios were inevitable. One, although the NPC was dominant because of British preferential treatment and the norths huge land mass compared to the other two regions in the south, none of the parties could govern Nigeria without forming a coalition with at least one other party. Two, because the three main parties were established along ethnic lines (except for NCNC which in its earlier stages was truly nationalistic in outlook) ethnic rivalries and mutual suspicion created a fertile soil for inter-ethnic conflicts.

The first indication that post-independent Nigeria would be problematic was in 1953 when, through Anthony Enahoro, the AG and NCNC tabled a motion in the federal House of Representatives calling for Nigerias independence in 1956. But the NPC led by Ahmadu Bello, for whom independence on that date was an invitation [for the north] to commit suicide, objected, claiming, correctly, that the north did not have adequate administrative machinery and educated personnel to run a modern democratic government independently of Britain.

That was why, when northerners who were majority in the House diluted Enahoros motion by recommending that independence should be attained when it is practicable to do so, they were heckled and jeered at by crowds in Lagos for foot-dragging on the independence issue. Some key members of the northern establishment and a broad section of northerners neither forgot nor forgave the south for that embarrassment.

Most Nigerians do not know that Britain had already made up her mind to hand over power to northerners by October 1, 1960, thereby laying the foundation for caliphate colonialism, despite the huge educational gap between the north and the south, the economic dependence of the former on the latter, and reluctance of prominent northern leaders to key into the quest for self governance.

That was why the British colonial office abruptly brought Sir James Robertson from Sudan as the last expatriate governor-general of Nigeria to conduct the 1959 elections, which he manipulated to favour the NPC. Ordinarily, in the interest of merit, fairness and justice, Sir Robertson and his cohorts ought to have worked hard to ensure that the first set of leaders for indepemdent Nigeria emerged from a free and fair election.

Of course, that is wishful thinking: the colonial master was not interested in transferring power to the most competent Nigerians or in building a strong and viable black nation that would eventually explode the white supremacist myth that black peoples are incapable of managing their own affairs without the guidance of whitemen. Besides, northerners preferred British rule to what they imagined as the dangers of being dominated by the south. Their leader, Sir Ahmadu Bello, expressed this fear: A sudden grouping of the eastern and western parties (with a few members from the north opposed to our party) might take power and so endanger the north.

Thus, aside from wanting to reward the north for its pro-British stance, Britain rigged Nigerias independence elections so that its compliant friends in the north, such as Ahmadu Bello and Tafawa Balewa, would win power, dominate the country and serve British interests after independence. This is in line with the psychology of oppressors and colonilalists identified by the psychiatrist and political political philosopher, Frantz Fanon, who posits that colonial masters invariably prefer stooges as their successors, those who would depend on them and who they can easily manipulate.

Chinweizu reports that Sir Robertson named Balewa as Prime Minister in 1957 inspite of the fact that the NPC controlled only one region and a third of the ministers in the federal executive council whereas the NCNC members were dominant in the east and west and had two-thirds of the ministers at the federal level. There is a personal angle to this brazen unfairness as well: the British Man Friday confessed that he became very close to Sir Tafawa Balewa to the extent that they could discuss virtually everything, including Balewas difficulties with noisy southerners who seemed to take all their squabbles and troubles to him.

As I pointed out earlier, Sir James Robertson was seconded to Nigeria from Sudan, a country dominated by muslims. Therefore, since like old soldiers old habits die hard, he was more comfortable handing over power to a muslim school teacher who the western world had hyperbolically and cynically propped up as a great statesman rather than to Dr. Nnamdi Azikiwe, leader of the NCNC and a brilliant political philosopher with a doctorate degree from Lincoln University, United States.

At independence, the incendiary plan of British colonial administrators was successful. Sir Balewa became Prime Minister while Sir Ahmadu Bello decided to remain Premier of northern Nigeria. Aside from Britains complicity in the process of northern entrenchment at the centre, two critical observations must be made at this point. First, before independence most prominent northern politicians preferred the north to the entire country, and they did not change their obsessive fixation with the region even after independence.

Sir Ahmadu Bellos arrogant and insensitive remark that I would rather be called Sultan of Sokoto than President of Nigeria sums up the attitude of key members of the northern ruling elite to the idea of a united Nigeria as a sovereign geopolitical entity. Therefore, when Nigerian leaders from the north claim that Nigerias unity is not negotiable, as if notherners are more patriotic than their southern compatriots, they must be reminded that Ahmadu Bello, Tafawa Balewa and most of the prominent northerners assassinated in the first military coup of January 15, 1966, and whose deaths were avenged by northern soldiers and civilians who murdered and maimed tens of thousands of Ndigbo, including many senior Igbo military officers, never really believed in or worked for Nigerian unity.

Instead, they used threats of separation and violence to armtwist wily British colonial administrators and squabbling disunited southern politicians to get concessions favourable to the conservative ruling elements in the north. The change from threats of secession by Ahmadu Bello and his cohorts to morbid obsession with Nigerian unity by successive northern military dicatators and prominent politicians was motivated by the ideology of caliphate colonialism set forth shortly after independence by Sir Ahmadu Bello himself: The new nation called Nigeria should be an estate of our great-grandfather, Uthman Dan Fodio. We must ruthlessly prevent a change of power. We use minorities of the north as willing tools and the south as a conquered territory and never allow them to rule over us, and never allow them to have control over their own future.

In other words, Sir Ahmadu Bello proposed that external colonisation by Britain should be replaced after independence with internal caliphate colonialism by muslim northerners so that Nigeria would remain perpetually the inheritance of the arch jihadist, Uthman Dan Fodio. In my opinion, no single pronouncement by any Nigerian explains better the fixation of the dominant faction of the northern ruling power bloc to our feudalistic federalism and irrational quest for political power at the centre.

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The anatomy of caliphate colonialism (2) - Vanguard

‘Grey’s Anatomy’ season 13 coming to Netflix next month – Blasting News

Greys Anatomy fans can rejoice. Season 13 of the show will be on Netflix US very soon. It will come later to the rest of the world, where the show is currently available. The June release on Netflix is due to a licensing agreement with the United States version of the streaming service and #ABC.

Greys Anatomy season 13 will be available on June 17. This is exactly 30 days after the air date of the season 13 finale. ABC and Netflix US have had an agreement for the last few days for the full season to be made available for streaming 30 days after the finale. Most fans have been expecting this release since knowing the date of the finale, but Netflix has only just confirmed this news.

The same day will see the release of another Shonda Rhimes drama. Scandal season 6 will be made available in full on the US version of the streaming service. How to Get Away with Murder season 3 has been available on the streaming service since March 23, 2017.

For the rest of the world, the exact date is unknown. It is highly likely that most countries will get Greys Anatomy season 13 around the middle of September, just before season 14 starts on the network.

There are a few other notable mentions for Netflix in June. The CW also has an agreement with the streaming service. Eight days after season finales, the full season of all shows will be available. For June that means Arrow season 5 and The 100 season 4 will be available in full on the first of the month and Reign season 4 will be available on June 24.

The Flash and Supergirl will be available at the end of this month. Supernatural is already availablereleased in full just yesterday. Riverdale is also already available on the streaming service, with The Originals, and iZombie coming towards the start of July.

ABC also has an agreement with other shows. Quantico and Marvels Agents of S.H.I.E.L.D will be available on June 14 and June 15 respectively. Shooter season 1 and Baby Daddy season 6 are also coming to Netflix this month.

Of course, fans also want to know when new episodes will be released. There is currently no confirmed date for the release of Greys Anatomy season 14. However, fans can realistically expect towards the end of September 2017. September is usually when new episodes are released on ABC. The show will keep its Thursday night 8 p.m. slot for the fall 2017 schedule. #Grey Anatomy #Grey's Anatomy

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Experimental Physiology Archives – Retraction Watch at Retraction … – Retraction Watch (blog)

Researchers have retracted a 2016 paper after discovering that they accidentally administered three times the reported dose of anesthesia to rats.

In theExperimental Physiology paper, the authors set out to mathematically map how rats blood pressure changes under different conditions, which required the rats to be anesthetized. But their findings were called into question when theyfoundthe rats had received a much higher concentration of anesthesia than intended. According to the notice, this higher dosecompromisedthe objectives of the experiment.

The corresponding author Karol Ondrias, from the Institute of Molecular Physiology and Genetics at the Slovak Academy of Sciences in Bratislava, told ushow the dosing error occurred: Read the rest of this entry

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Neuroscience – Elsevier

Welcome to the Neuroscience area of Elsevier.com which provides you with access to news, resources and information about Elsevier's publications in Neuroscience. By delivering first class information and innovative tools, we continue to refine our portfolio to serve the research need of educators, researchers and students worldwide.

We are proud to play an integral part within the Neuroscience community and to participate in the advancement of this field. All our journals are available online via ScienceDirect, http://www.sciencedirect.com, the essential information resource for over 14 million scientists worldwide.

For full aims and scope, to submit your articles or subscribe, visit the journal homepages.

Undoubtedly you have experienced the short comings and occasional frustrations associated with the manuscripts submission and peer review processes. Our aim is to help facilitate and develop fast, effective and truly innovative solutions to improve the overall manuscript submission and peer review process for all individuals concerned.

Take advantage of our new easy article transfer service and avoid the hassle of resubmitting to another journal.

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We are committed to working in partnership with the research community, librarians, funders and other stakeholders. Our Elsevier team is continually on the road meeting the community, participating in discussions and establishing partnerships which will help support increase access to research. Read more about our institutional and funding body agreements.

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Make valuable and lasting contributions to the health and future of society. Understanding the ethical boundaries in scientific research and publishing is a key step in making sure your work gets off to the best start. From there, anything's possible.

The Ethics in Research & Publication program is the collaboration of an independent panel of experts in research and publishing ethics and Elsevier. Visit the website for resources and tools so you can proceed confidently.

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Featured Archives – Neuroscience News

Featured articles can cover neuroscience, brain research, regenerative medicine, psychology, genetics, robotics, neurology and many other cognitive science topics. Featured neuroscience articles are articles that we believe to be very important, or that our readers will most likely want to read. Featured articles usually include an image and tend to be shared more across the social networks.

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Featured Archives - Neuroscience News

Neuroscience | Psychology

Neuroscience research at UWM involves students and faculty from several departments as well as psychology. The work being done in the Psychology Department is aimed at understanding the relationships between the functions of the nervous system and behavior/cognition. Faculty use a wide range of techniques with laboratory animals and human subjects study these issues.

Some of the current topics being investigated by psychology faculty include: neural changes following complex motor skill learning, mapping human brain areas involved in memory and emotion with magnetic resonance imaging, interactions between endogenous dopamine and drugs of abuse, characterization of novel antipsychotic compounds, effects of exercise on cerebral blood flow, the role of opioids and other peptides in pain and analgesia, development of aquatic models of drug abuse, and the neural systems analysis of Pavlovian conditioning and defensive behavior. Neuroscience research and training is currently supported by grants from the National Institutes of Health as well as private foundations.

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Neuroscience | Psychology