Queen’s University Belfast Vice-Chancellor Patrick Johnston dies suddenly – Belfast Telegraph

Queen's University Belfast Vice-Chancellor Patrick Johnston dies suddenly

BelfastTelegraph.co.uk

Queen's University Belfast's Vice-Chancellor Patrick Johnston has died suddenly.

http://www.belfasttelegraph.co.uk/news/northern-ireland/queens-university-belfast-vicechancellor-patrick-johnston-dies-suddenly-35787432.html

http://www.belfasttelegraph.co.uk/news/northern-ireland/article35787511.ece/af72b/AUTOCROP/h342/2016-09-19_new_24750948_I1.JPG

Queen's University Belfast's Vice-Chancellor Patrick Johnston has died suddenly.

The news of his death came in an email to staff from the university's registrar, James O'Kane on Sunday afternoon.

Professor Johnston's cause of death has not yet been revealed. Queen's University has said more information will be made available.

Obituary: Prof Patrick Johnston - a great mind whose work saved lives

In a statement the Queen's University said: "It is, with a deep sense of shock and loss, that I have to announce the untimely and sudden death of our Vice-Chancellor, Professor Patrick Johnston, earlier today.

"We extend our deepest sympathies and condolences to Iseult, his wife, and their four boys, Seamus, Eoghan, Niall and Ruairi, and the wider family circle at this desperately sad time.

"We will provide further updates in due course."

QUB academic and green party councillor John Barry said the news would come as a shock to staff at the Russell group university.

He said: "He was our first locally based Vice-Chancellor in quite some time - and was extremely youthful and energetic. It's a complete shock."

His loss will be felt not just at home here in Northern Ireland but right around the world where he was hugely respected. DUP leader Arlene Foster

The SDLP's Dr Alasdair McDonnell paid tribute to the "powerful figure" and said he was deeply saddened by news of Professor Johnston's death.

He said: "I am deeply saddened to hear the news of the untimely death of Professor Paddy Johnston. His death is a terrible loss to Queens University, cancer research and Northern Ireland.

Professor Johnston was a powerful figure, working to find a cure for cancer. One of his greatest achievements is undoubtedly leading the establishment of the Centre for Cancer Research and Cell Biology in Belfast.

I express my deepest sympathies and condolences to his family and QUB colleagues at this difficult time.

UUP MLA Alan Chambers said: "Many will remember Patrick particularly for his work in leading the establishment of the Centre for Cancer Research and Cell Biology.

"For his tireless work in this field we are indebted to him."

His loss will be keenly felt also by all those who admired his determination to find a cure for cancer and who respected his decision to return to Belfast to lead the Centre for Cancer Research. Sinn Fein MLA Mairtin O Muilleoir

Professor Johnston from Londonderry was the first person to be appointed President and Vice-Chancellor from within the staff of Queens since the appointment of Sir Peter Froggatt in 1976.

Professor Johnston was regarded as one of the world's leading cancer researchers.

He joined Queens University in 1996 as Professor of Oncology, later leading the establishment of the Centre for Cancer Research and Cell Biology.

Since then CCRCB has revolutionised cancer treatment in Northern Ireland and further afield. It now has 250 researchers from all over the world and was designated a Cancer Research UK Centre in 2009.

Until taking up the post of President and Vice-Chancellor of Queens in March 2014, Professor Johnston was Dean of the School of Medicine, Dentistry and Biomedical Sciences where he led the foundation of a new international Medical School and Institute of Health Sciences.

His own research focus over 25 years has been on the understanding of mechanisms of drug resistance to therapeutic agents.

This resulted in a number of prestigious landmark publications, more than 20 patents and the award of grants of 95m from research and philanthropic bodies including Cancer Research UK, the Medical Research Council, Atlantic Philanthropies, the Department of Health, Social Services and Public Safety and the National Institute of Health.

In 2012 he received a Diamond Jubilee Queens Anniversary Prize from Her Majesty The Queen for the University-led reorganisation of cancer care in Northern Ireland.

Belfast Telegraph Digital

More:
Queen's University Belfast Vice-Chancellor Patrick Johnston dies suddenly - Belfast Telegraph

How I Aced Biochemistry – PreMedLife – The Lifestyle Magazine for Pre-Medical Students

College hallways abound with rumors on the blood, sweat, and tears that accompany biochemistry. Mechanisms, pathways, enzymes Anxiety crept upon me after I signed up for the class and anticipated syllabus day until I stood up, determined, that I willsucceed biochemistry! I understand the heavy workload, tediousness, and specificity of the material, so I would like to share a handful tips on how I aced the class!

When we hear judgments, we could feasibly become influenced by their opinions and prejudge our experiences before we even set foot. I eventually decided to block out peoples opinions on the class, and focus on making the course my own experience. It is crucial to realize other peoples experiences do not determine yours. Further, avoid assuming the nature of the class. It may be boring, and on top of that, nearly impossible! I just hate memorizing pathways! Your attitude affects your performance. Perhaps, approach with a more open viewpoint of the class: It might be challenging, but Im open to learning about the underlying machinery of the human body. If you already find biochemistry intriguing, you are ahead of step one!

Some professors provide students with lecture notes online to print, as others do not. If your professor does not, recording the lecture could help tremendously to go back and listen to what you may have missed or to gain a more solid understanding. If the professor does provide online lecture notes, make sure to print them or download them onto your computer. I read over the lecture notes the same day of the class and quizzed myself over simple questions on the material on the notes. (Keep in mind: biochemistry includes application, critical thinking, and memorization, so your exam most likely may ask questions on a deeper level, but understanding the basics of the lecture is the point of quizzing yourself over the lecture notes). I divided the notes into sections and turned the stated lecture notes into questions to ask and quiz myself over. With this step, you will be familiar with what was covered in class.

A helpful way to perform on exams is to ask the professor if the lecture notes or textbook serve more as a basis for the exams. I studied lecture notes and read the textbook, regardless of when my professor stated the lecture notes were sufficient for the tests (reading the textbook chapters helped tremendously with the exams!) Not everybody prefers to read textbooks, or even needs the textbook for high performance, so this step depends on personal preference. As the material can be overwhelming, I divided my reading into paragraphs. I would read one paragraph once, read it again and highlight, then write my notes in my own words. Be sure to take breaks too!

You cannot go wrong with getting to know your professor! They could introduce you to resources that can help you, take time to elaborate concepts, and overall, help you along your academic journey. If you do not understand material, be sure to make time to visit your professors office hours with a list of things to ask. Emailing is a great option as well (if your professor checks it!); however, face-to-face interaction facilitates the ability to ask questions.

I am such a visual learner! It can be hard for me to visualize the chymotrypsin mechanism or the way translation works. Looking up these mechanisms on YouTube eased understanding of these concepts because I obtained a visual grasp on how they work.

My professor provided us with practice exams for the class; however, if your professor does not, worry not! I sometimes chose not to go with the exams the professor offered and googled biochemistry practice exams for a particular set of topics. It obviously will most likely not resemble your exams difficulty, application style, etc., but it will help train you to apply your knowledge, rather than soak up everything you have learned without using it. Be sure to practice those math problems too!

I have disappointed myself a few times throughout the class, and overall, my college experience. It happens! We are human. Breathe. What matters is your attitude, which drives the recovery. If you did not get the grade you expected, contact the professor, let him/her aware of your concern and what you can do to perform better next time, go over the exam, go over practice problems, etc. At the end of the day, you are taking a challenging class and are willing to succeed! Give yourself credit for the amazing effort you are putting in! Believe in yourself!

Originally posted here:
How I Aced Biochemistry - PreMedLife - The Lifestyle Magazine for Pre-Medical Students

Anatomy of two at-bats: Roberto Osuna overrules Aaron Judge in Blue Jays’ victories – The Athletic (Toronto) (subscription)

Anatomy of two at-bats: Roberto Osuna overrules Aaron Judge in Blue Jays victories

Join the community of the most die-hard Toronto sports fans, players, and executives who subscribe. The best writers. Unique content. No ads, no fluff.

Already a User?

Original post:
Anatomy of two at-bats: Roberto Osuna overrules Aaron Judge in Blue Jays' victories - The Athletic (Toronto) (subscription)

‘Grey’s Anatomy’ Season 14 spoilers: Meredith, Nathan together again? – Blasting News

Fans are hoping to see Meredith and Nathan together again in the upcoming Season 14 of "#Grey's Anatomy." So, what should the fans expect in the new season of the hit ABC drama?

According to new reports, Meredith (Ellen Pompeo) and Nathan (Martin Henderson) might be able to continue their relationship in "Grey's Anatomy" Season 14. Their relationship could finally get through the struggles that fans saw in the ending of GA Season 13.

There is no doubt that "Grey's Anatomy" Season 13 left a lot of cliffhangers in the story. Speculations are making the rounds that Meredith and Nathan might finally rekindle their romance in the upcoming GA Season 14.

Meredith and Nathan's relationship was affected by the return of Megan. In Season 13 of the show, Megan, Owen's sister, and Nathan's fiance were found to be alive after disappearing for several years. People thought she had already died, but the lives and relationship of Nathan and Meredith will change now that she is back. Although Meredith and Nathan's romance was just getting started, it seems like it has already ended now that Megan is back.

During the Season 13 finale of the show, Meredith was the one who broke the news to Nathan. She told hem that Megan is actually alive and urged him to visit her. Meredith even told Nathan that she would have rushed to Derek if she knew he was alive. It seems like Meredith is willing to give up Nathan just to see him happy. However, fans are worried about the future and happiness of Meredith.

It was clear that Meredith was actually ready to introduce Nathan to her kids as her boyfriend. She was even ready to let her friends know that he and she are already dating. However, Megan's return has affected their new relationship.

Rumors are now making the rounds that Megan's traumatic experience might cause her to refuse to go with Nathan. If this happens, then Nathan can finally move on with Meredith. Fans are hoping to see the two continue their relationship in GA Season 14.

Reports claimed that the fans are tired of seeing Meredith unhappy, which is why they are hoping to see her end up with Nathan in GA Season 14. Hopefully, the producers of the show can hear the fans out.

"Grey's Anatomy" Season 14 comes back on small screens in the fall and will air every Thursdays at 8/7c on ABC. #Grey's Anatomy Season 14 #Grey's Anatomy meredith

Read the original post:
'Grey's Anatomy' Season 14 spoilers: Meredith, Nathan together again? - Blasting News

Diagnostic Services – JFK Medical Center

Types of Neurological Disorders

The Neuroscience Institute specializes in the diagnosis and treatment of:

Causes of Neurological Disorders

People of all ages are at risk for neurological problems. Some common causes include:

The NJ Neuroscience Institute offers advanced diagnostic resources to assist physicians in the accurate and timely assessment of neurologic disorders. This includes a comprehensive collection of monitoring devices, which are available on an outpatient, inpatient and intraoperative basis.

Advanced diagnostic techniques rely on a combination of tests and a careful historical understanding of the problem. Tests available at the Institute include:

The specialists at the NJ Neuroscience Institute take a multidisciplinary team approach, relying on open communication, to ensure a unique treatment program for each patient. These disciplines include:

Read more here:
Diagnostic Services - JFK Medical Center

What does neuroscience have to do with family business? – grbj.com

One mid-November night, I was driving down a country road with my 15-year-old son. I was distracted by intractable problems going on within my family. Suddenly, I saw a stop sign whizzing by me, and I realized there was no way I could stop in time. We hit a car going 40 miles per hour.

My life was spared that day, and so were the lives of the two women I hit and the life of my son.

But what a scary thing! Imagine how youd feel if you hurt or killed someone because you werent paying attention!

That accident was no accident; I wasnt fully present behind the wheel. I was distracted by problems I was tolerating and not resolving.

Im not alone, of course. How many of us dont attend to the relationship problems at hand? It is common to read about the challenging dynamics of Family-Owned Businesses (FOB):

But what do you do to resolve them? Many FOB leaders dont resolve them; they tolerate them. Their health suffers and their relationships at home become strained. They start counting the days until something changes and their lives at work become easier maybe having extra drinks at night to be able to sleep, maybe staying distracted through working harder and longer, hoping the conflicts will sort themselves out.

The day of my car accident was a huge wake-up call. I decided there in the middle of the road to pay attention in my life, take responsibility and address the problems before me.

Maybe youve had a wake-up call something that shook you to the core and made you pay attention. Maybe not. Either way, we owe it to ourselves to be present, to take responsibility and resolve the problems that plague us in our family and business.

Heres a story to illustrate. Joe called me one day because of his escalating health problems. He was the youngest sibling in a family-owned business and was frustrated at every turn. As we talked, it became clear he was extending early family conflicts into the business today, playing by rules that were established when he was young. He didnt dare take action without express permission and often interpreted his brothers comments through the lens of you dont give me enough credit. He was constantly angry about his lack of power, and it was literally killing him.

What Joe learned is that his own mindset created both the problems and the solutions and that by taking responsibility for everything in his life, he could create major change. For example, when he thought he was being treated with disrespect, that was indeed his experience. When he decided that his perceived lack of respect was just perception, he felt more empowered to enact his vision.

Some people believe that taking responsibility for everything in their life is unrealistic or creates a blame the victim mentality. But in fact, taking responsibility for everything in your life allows you the freedom and opportunity to create the life and business you want.

Theres a saying about the brain that goes like this: Neurons that fire together, wire together. What we believe gives rise to our thoughts, which generate our feelings, which produce our actions, which create our results, which reinforce our beliefs. Our results make us think we were right to believe what we did in the first place! We perpetuate current reality in our brains neural networks and in our lives.

The way out of this loop is to take responsibility for our thoughts and actions and shift our mindset to actually change those original, often unconscious beliefs.

Here are three steps to shift your mindset:

1. Establish your vision: Dwell in possibilities of what you want to see in your business. Dont get stuck on how things currently are, spend time imagining how you want them to be. The brain doesnt know the difference between real and imagined experiences (hard to believe, but true). The more time you spend visualizing the relationships and communication you want to have, the more you will see opportunities to create this.

2. Identify the obstacles: What old family rules have you adopted that youre consciously or unconsciously following? Talk to someone or write for five to 10 minutes to discover how playing with these old rules blocks your effectiveness and satisfaction. One way to discover these rules is to look at whats not working for you, what doesnt feel good in your day-to-day functioning and what would feel more satisfying to you.

3. Make new decisions: If the old rules no longer serve you, decide to establish new rules. Instead of I cant take action without express permission, decide that the fellow leaders in your family trust you and trust your actions. Then take action from a place of integrity. Or, if you feel trapped by a family system and dont believe you can get out, decide there is always a way out. It is amazing what a new decision will do to create a sense of freedom and self-confidence.

The complexities within family-owned businesses abound. This is not new information! When we get stuck in patterns that dont work, when we dont see a way out, when our health or ability to be present in our lives suffers, its important to take responsibility and do whatever is required to resolve the issue.

Sometimes taking responsibility means reaching out and getting some assistance. When our cars break down, we take them to the shop. Most of us dont wait until they break down! We bring them in for oil changes and regular tune-ups.

Do the same for yourself and your family business. Tend to your life and the issues in the family at least as much as you would your car. Take responsibility and see what is possible!

Nancy Jonker, Ph.D, is a mindset coach serving entrepreneurs, family business owners and successful professionals. She aids family business owners in identifying leaders strengths, facilitating conversations and family meetings and improving team functioning.

More:
What does neuroscience have to do with family business? - grbj.com

A Periodic Table of Behavior for Psychology – Psychology Today (blog)

Modern science took off during the Enlightenment and changed the world. Science was differedfrom philosophy in that it did not presuppose how nature must be, as the early philosophers tended to do, but instead scientists got up out of their armchairs and asked questionsand gathered data about howuniverse actually behaved.Observation, measurement and experimentation became the sine qua non of the scientific enterprise, and this has continued into the present day.

Science has been so successful that philosophy has drifted into the background, so much so that some scientists (e.g., E. O. Wilson) have wondered if philosophy is even necessary. This love of empiricism was soaked up by scientific psychologists. In his popular Psych 101 text, David Myers states that the key word in psychologys definition is science and that psychology is less a set of findings than a way of asking and answering questions,meaning that psychologists approach their subject matter through the lens and methods of empirical science.

What is the problem with this?The problemthat emerges is thatthere is no general framework for understanding the concepts and categories under investigation. Consider physics. Prior to Newton, physics was a pre-paradigmatic mess, meaning that the concepts and categories that physicists were using were highly inconsistent. One of the great achievements of Newtonian science was the emergence of a shared definitional system that could be examined empirically. Notice the first part of this sentence. A shared definitional system. That is a key aspect of cumulative science. And it is something physics, chemistry and biology largely have achieved, at least at the core of the discipline. That is, they know generally what matter, energy, electrons, neutrons, genes, cells, evolution and so forth "mean".And is one of the decisive factors that makes themworthy of the name"science".

Psychology completelylacks a shared definitional system. There is NO agreement on terms like behavior, mind, cognition, self, consciousness, and the like. And, with its focus on empiricism, psychology will not achieve such an understanding because observation and experiment alone are not enough to define these terms. What is needed is a holistic map that allows investigators to consider the concepts and categories that are used for understanding.

The concepts and categories that one uses to map reality is ones metaphysical system. The Periodic Table of the Elements is a metaphysical system. It offers a map of the elements, lining them up into different categories. It is a map that is supported by empirical work, but the map itself is metaphysical in nature.

Psychology needs a metaphysical system for understanding as much as it needs empirical research. Without advances in achieving a shared metaphysical system, psychology will continue to exist as a collection of studies that offer interesting glimpses into the human condition, but not deep understanding.

The Tree of Knowledge System offers the field of psychology (and science in general) a metaphysical system from which to operate. Specifically, it offers a clear: (a) cosmology; (b) ontological map of key categories in nature; and (c) epistemological framework for knowledge acquisition.

In terms of cosmology, the ToK System offers a Big History view of the Universe. Consistent with empirical work on the early universe, the ToK System posits that we can understand the universe as an EnergyMatterSpaceTime grid that emerged from a (pure energy) singularity at the Big Bang, approximately 13.8 billion years ago.

In terms of ontology, in the ToK System, Energy is the ultimate substance common denominator. The observable universe is "Energy" in all its different forms (Matter is chunked, frozen energy).The ToK further posits that universe evolves as an unfolding wave of Energy-Information, which, consistent with the Big History formulation, can be placed on the dimensions of time and complexity.

Furthermore, the ToK System posits a general behavioral metaphysics. That is, the ontological essence of the universe can be well-described as change in object-field relationships over time (also characterized as the flow of Energy-Information).

Because the ToK posits the essence of the universe exists as an unfolding wave of Energy-Information, the ToK gives rise to a novel view of primary categories in nature. Specifically, it argues that there are four identifiable dimensions of complexity, which are depicted and labeled Matter, Life, Mind and Culture. These dimensions capture the behavior of 1) objects; 2)organisms; 3)animals and 4)humans. It proposes that these core categories are differentiated because each category behaves in a fundamentally novel way. That is, living objects behave qualitatively differently than inanimate objects. Animal objects behave qualitatively differently than other kinds of organisms. And human objects behave differently than other animals.

According to the ToK, these fundamental divisions exist because of the evolution of different systems of information processing. The storage and processing of information on the DNA molecule gives rise to fundamentally different kinds and levels of self-organization, such that the workings of a cell are qualitatively different than the behavior of organic molecules (and are represented as existing on a separate dimension of self-organization and require a different science, biology, to describe explain and predict).

The emergence of a nervous system in general and brain in particular gave rise to another information processing system that resulted in animal behavior and experiential consciousness, which are qualitatively different behavior patterns than are seen at the level of the cell or molecule. The Mind, Brain, and Behavior sciences (behavioral neuroscience, computational/cognitive neuroscience, comparative psychology, ethology, etc) describe this specificdimension of behavior. The ToK System characterizes these class of sciences basic psychology, although it should be acknowledged that, given the fields institutional history, perhaps this cluster should perhaps just be labeled thesciences ofMind, Brain, and Behavior.

Last, the emergence of language connected human minds together in novel way, giving rise to human culture and societal group organizations that are fundamentally different than is seen in the rest of the animal kingdom.

The general behavioral metaphysics of ToK System gives rise to a Period Table of Behavior, depicted here. A novel feature of the ToK categorization system of these concepts is that it positsthat nature must be divided into both levels (part, whole, group) AND dimensions of complexity (Matter/Objects, Life/Organisms, Mind/Animals, and Culture/Humans).

In terms of epistemology, the ToK System is both empirical and metaphysical, meaning that it emphasizes knowledge acquired through the senses and experiment and emphasizes the need to place such datainto a coherent conceptual framework. It is the union of empirical data with coherent conceptual mapping that provides the most justified knowledge. This can be referred to as a Metaphysical Empirical epistemological position.

The ToK System is consistent with modern physics, chemistry, and biology. It is particularly useful at the level of psychology because it provides a new way to define behavior in general. Behavior is the unfolding wave of Energy-Information. Thus, Matter and Life behave. Psychologists have been horribly confused about this point. The ToK makes the common sense pointthat psychologists are interested in a particular kind of behavior, specifically mental behaviors, which are represented by the third dimension of complexity on the ToK System.Mental behaviorsare the behaviors of the animal as a whole, mediated by the nervous system.In such a formulation, the mind refers to the functional information stored and processed by the nervous system. It is largely synonymous with the broad definition of cognition. Here is a map of the information processing architecture of the human mind.

In the ToK System, experiential consciousness is conceptualized as an embodied whole brain activity that gives rise to experiential awareness, and is well defined and studied empirically by frameworks such as global neuronal workspace theory.

Humans exhibit mental behavior like other animals, but there is an added dimension of complexity. Human language connected human minds, much like the internet connects individual computers (and much like the nervous system connected organ systems in a centralized control center). This results in a qualitative jump in behavioral complexity. Language, along with other technological developments like agriculture, historically set the stage for massive societal/cultural evolutionary changes. As society became more and more complex, large scale belief/justification systems emerged, such as religion, law, and science. Such systems are denoted as Culture with a capital C.

Human self-consciousness is a second order form of consciousness in which the experiential conscious system is reflected upon and narrated, either to ones self (private self-consciousness) or to others (public self-consciousness). The human self-consciousness system functions to build justification systems for ones actions in society. Thus, there are three key domains to human consciousness. An experiential theater of first person awareness, an I-Me second order private self-consciousness system and an I-Thou public self-consciousness system. Here is a map of human consciousness.

Psychologistsstronglyaspire fortheir discipline to be a "real" science. However, to accomplish this dream, psychologists need to realize that empiricism per se is not sufficient. If each researcher continues to operationalize the mind, behavior, cognition, consciousness, or whatever phenomena of interest they are investigating via their own (metaphysical) system of understanding, then, despite the best experiments, all we will have is conceptual mush because there will be no way to relate the findings systematically. The ultimate goal of the field is not to just conduct experiments. It is to build a system of cumulative knowledge about human mental behavior. This is why we need something akin to a Periodic Table of the Elements. The ToK offers the field a Periodic Table of Behavior.

View post:
A Periodic Table of Behavior for Psychology - Psychology Today (blog)

5 factors raise hospitalization risk for kids with autism – Futurity: Research News

A new study identifies which factors put young people with an autism spectrum disorder (ASD) at high risk of being hospitalized for inpatient psychiatric careincluding factors both related and unrelated to ASD itself.

Children or teens with autism spectrum disorders often come to hospitals when behavioral episodes overwhelm the support that caregivers can provide at homebut resources at hospitals are sometimes limited, too, says Giulia Righi.

The demand is far greater than the number of clinicians, the number of programs, and the number of beds we have, says Righi, a research assistant professor of psychiatry and human behavior at the Warren Alpert Medical School of Brown University, who treats acute care patients with autism spectrum disorders.

The strongest risk factors are not necessarily associated with ASD.

One of the biggest issues is the availability of acute care services such as day hospital programs and inpatient units to support families when their childrens behaviors have escalated to the point of making a situation unsafe at home, at school, or sometimes both, she adds.

Identifying and addressing the factors that make hospitalization more likely, she says, could reduce such instances. Notably, only two of the risk factors identified in the study of patients with an autism spectrum disorder (ASD)their severity of autism symptoms and the degree of their adaptive daily life functioningwere specific consequences of the disorder.

The strongest risk factorsdisrupted sleep, having a mood disorder, and living in a home with a single caregiverare not necessarily associated with ASD.

Our results underscore the importance of a multidisciplinary approach to the assessment and treatment of children and adolescents with ASD that addresses behavioral, psychological and psychiatric, adaptive, sleep, and medical functioning in order to decrease behavioral crises and the utilization of inpatient psychiatric services, Righi and coauthors write in the study published in theJournal of Autism and Developmental Disorders.

The study made unique use of two large datasets with unusually rich information about patients, Righi says: the Autism Inpatient Collection (AIC), which includes data from childrens psychiatric hospitals in six states, and the Rhode Island Consortium for Autism Research and Treatment (RI-CART). Founded in 2013 by a coalition of local institutions including Brown, Bradley Hospital, and Women & Infants Hospital, RI-CART has grown to become a community of about 1,500 patients and their families.

In the research, Righi and her coauthors looked at the AIC records of 218 patients age 4 to 20 who were hospitalized and compared them with 255 age- and gender-matched members of RI-CART who were not hospitalized. By employing statistical analysis techniques, the researchers were able to isolate risk factors that were independently and significantly associated with the risk of hospitalization.

The strongest predictor was the presence of a mood disorder, which was associated with a seven-fold increase in the odds of hospitalization. The presence of sleep problems was the second strongest risk, more than doubling the odds. A high score on a standardized scale of autism symptom severity raised the odds a little bit, though still significantly.

Meanwhile, having a high score on a standardized scale of adaptive functioning, or basic life and coping skills, slightly but significantly lowered the odds of hospitalization. Finally, children and teens in households with married caregivers had only 0.4 times the odds of needing hospital care compared with comparable patients living with only one adult caregiver.

That last result, Righi says, is likely not about family structure or stability per se, but rather about resources available to cope with the care for a child with high needs. The hospitalization risk associated with mood and sleep disorders, meanwhile, points to the need to engage in a broad based and careful psychiatric evaluation of autism patients.

Our findings emphasize the utility of thorough assessment and treatment of mood and sleep conditions to decrease the likelihood of requiring psychiatric hospitalization, Righi and her coauthors write.

Righi notes that some factors she might have hypothesized would be independently significant were not, including the degree of intellectual disability or gastrointestinal problems.

Righi acknowledges that while research examined many factors, others that it didnt measure might also be important. Also, the study measured associations of risk factors with hospitalization but doesnt prove they were the cause of hospital visits.

But the study authors write that the risk factors they identified may be worth addressing before young autism patients reach the point where hospitalization becomes necessary.

In spite of its limitations, the study authors conclude, the present findings reveal indicators that may be useful for identifying children and adolescents at greater risk of psychiatric hospitalization as well as other potential targets for individual and family intervention.

The Hassenfeld Child Health Innovation Institute at Brown University helped to fund the study along with the Simons Foundation, the Nancy Lurie Marks Family Foundation, and the National Institutes of Health.

Source: Brown University

Read the rest here:
5 factors raise hospitalization risk for kids with autism - Futurity: Research News

Ancient Mummies Finally Give Up Their Genetic Secrets – Smithsonian

The sarcophagus of Tadja, one of the mummies from Abusir el Meleq that had its DNA analyzed in a new study.

Historically, the idea of extracting DNA from an Egyptian mummy has been a bit like trying to suck dinosaur DNA out an insect trapped in amber: a tantalizing prospect, but still more myth than science. "This has been around for a long time as a hot topic," says Johannes Krause, a geneticist at Germany's Max Planck Institute for Evolutionary Anthropology. But unlike the dino scenario, it turns out analyzing mummy DNA is actually scientifically possible.

Krause has spent his career teasing information out of very old DNA. His work has led to the discovery of a new subspecies of human, which he helped identify from a bone fragment in a European cave; he also definitively identified the disease behind the infamous Black Death by examining dug-up plague victims. Now he can add another ancient jewel to his list: mummies. His team has managed to extract the first intact DNA from thousands-year-old Egyptian mummies, allowing them to unravel the secrets of their genetic heritage.

The discovery comes out of a relatively new field known as archaeogenetics. It was founded by a Swedish biologist named Svante Pbo who claimed to have extracted the DNA of 23 ancient Egyptian mummies as a young researcher in the 1980s. However, Pbo's work fell under heavy criticism from other scientists when it became clear that his DNA samples could be contaminated with modern DNA, Krause says. By the 2000s, some experts had begun to question whether it was even possible to extract usable DNA from mummies that had been weathered for so long by the hot, dry Egyptian climate.

Advances in DNA sequencing technology in the past eight years, particularly "high-throughput" sequencing technologythat can sequence millions of DNA base pairs quickly, cheaply and accurately, have reopened the possibility that Egyptian mummies could give up their genetic secrets, Krause says. Last year, he and his colleagues aimed to learn more about the genetic makeup of ancient Egyptian peopleand particularly, how their population had been influenced by a particularly turbulent, thousand-year chapter of history.

Starting in the 8th century BCE, waves of migration and conquest from Rome and farther south in Africa shook the region. If they were indeed able to extract mummy DNA, Krause expected to find the effects of this period of invasionand, presumably, intermixingwritten in the genetics.

Drawing on two mummy collections from German universities, the team analyzed more than 150 mummies recovered from an ancient area of middle Egypt called Abusir el-Meleq, a thriving city along the Nile River where many Egyptians were buried starting in 1500 BCE. The mummies ranged in age from 2,000 to 3,000 years old. These were not pharaohs or wealthy Egyptians buried in elaborate stone sarcophagi, Krause says, but rather ordinary, "middle-class" people buried in simple painted wood coffins. "At the time, they mummified almost everything," Krause says, including pets and wild animals.

Using these new techniques, Krause was able to find complete mitochondrial genomes in the tissues of 90 of those mummies, according to a study published yesterday in the journal Nature Communications. While previous studies of ancient mummy DNA tended to focus on sampling from the remaining soft tissues of the bodies (i.e. muscle, skin and organs), Krause says his team found that actually the bones and teeth of the mummies best preserved the people's DNA, because these structures were less exposed to the heat and humidity that can degrade genetic material.

To rule out the contamination that sank previous studies, Krause relied on work of geneticists in the last decade who have learned how to track the damage that occurs to the structure of DNA as it degrades over hundreds or thousands of years. Newer, undamaged DNA that had contaminated a sample would now stand out in an analysis of older, pockmarked DNA. "With these DNA damage patterns, we're really able to authenticate ancient DNA," Krause says.

So how did the genetic makeup of the people living Abusir el-Meleq change in these turbulent centuries?

"Nothing really happened. It was very boring," Krause says with a laugh. Apparently, all that conquering didnt significantly change the genetics of this Egyptian populationwhich, in itself, was unexpected. That was actually a bit of a surprise to us, Krause says.

Next, Krause wanted to compare what he found in the ancient DNA to the genetics of modern Egyptians, drawing on a genetic survey in 2015 that looked at human migration out of Africa. Predominantly, the modern people sampled appeared to share the most genetic ties with people today living in the Arabic countries of the Middle East. This contrasts with modern Egyptians, Krause says, who now appear to have more genetic origins from sub-Saharan Africa.

This suggests that the invading peoples from Nubia and Rome didnt significantly intermix with the ancient Egyptians during the centuries before the year 0 ADbut that sometime since, a mass influx of African genes entered the Egyptian population.

American University in Cairo egyptologist Salima Ikram found Krause's work overall to be "well-balanced, well-researched, and well thought-out." However, Ikram, who was not involved in the study, is skeptical about how definitive Krause's comparison to modern Egyptians really is. The genetic survey of modern Egyptians cited by Krause does not specify where the people sampled were from, Ikram says, a data gap that could have big implications on the conclusion.

"Despite mobility, [there] are [still] pockets of ethnic groupings," Ikram says. Samples from southern Egypt or slave-trade centers could therefore show much more sub-Saharan African influence than samples from northern port cities that could have more European influence from the Crusades.

In future studies, Krause hopes to collect more mummy DNA from around Egypt to pinpoint when and why ancient Egyptians began to change geneticallyand to find out exactly how their ancestors migrated to the fertile crescent in the first place. "What we're most interested is extending the data back in time," he says.

Like this article? SIGN UP for our newsletter

Read more here:
Ancient Mummies Finally Give Up Their Genetic Secrets - Smithsonian

Weekend: Elementary school classroom gets ‘egg-cited’ – The Courier

By KAREN McDOUGALL The incredible egg. An incubator filled with fertilized eggs was the star of a three-week stay in an elementary school classroom when I was the 4-H program assistant. Why? One of the school enrichment programs is the chick embryology program, Hatching Future Scientists. Along with the fertilized eggs, there were many questions and much learning. When going into the classrooms, the students always asked how long it would take for the eggs to hatch. It takes about 21 days. To make this real for the students, a hatching book was created. Starting with day one, this book gave a day-by-day look at the development of the chick inside the egg. We talked about why the chickens laid colored eggs: white, brown, blue or green. How? The color of the chickens earlobes determined the egg color. Chickens with white earlobes lay white eggs. Chickens with red earlobes, the students would say lay red, but these are the ones who lay the brown, blue or green eggs. Most of our eggs were brown eggs and were specific breeds. We could tell if they were male or female by their color after they hatched. Have you ever noticed the white spot or germ spot on the egg yolk? This is where the chick will start to develop if the eggs are fertilized. When a hen sits on her eggs, her body heat incubates the eggs. She turns them with her beak, which is part of her maternal instincts. The average clutch a hen hatches is 12 eggs. The students asked where the developing chick got its food. Nutrition comes from the yolk. It was quite interesting to process. Our incubator had a turner, which would turn the eggs every 30 minutes. If the humidity or temperature is off, the development and hatching of the eggs is affected. Fertile eggs are set in the incubator on the first day in the classroom. Humidity and temperature controls are carefully monitored. Between 38 and 60 hours after the eggs begin to incubate, many things start happening inside the eggs. The heart is beating. The upper part of the embryos body turns on its side. The eyes, ears and brain take shape. On days four and five, wings and legs are growing and the chick is moving inside the egg. On day nine, the eyelids form and on day thirteen the eye closes. One highlight for the students is candling the eggs. This is done around day 10. What is candling? Shine a small light into the large end of the egg, darken the room and we are able to see inside the egg. Seeing nothing means the egg is not fertile. One sign of a developing chick is the blood vessels growing around the embryo. Many times a black dot is visible, which is the chicks eye. If conditions are right, the students are able to see the chick move inside the egg. During my second visit, we did eggsperiments. Spinning eggs indicated if we had a raw or hard-cooked egg. Eggs that float indicate whether they are spoiled or good to eat. The answers? Hard-cooked eggs spin faster. If the egg floats, throw it out. On day 18, the egg turner is unplugged so the chicks can get themselves ready to hatch. The chick makes a small hole in the egg shell, then pecks its way around the egg. When completed, the chick makes its appearance in the classroom. Once the chicks are dry, the teachers put them in a special container with food and water. The students are able to hold them and feel how soft and delicate they are. By the time I stopped to pick up the chicks, they were starting to have feathers on their little wings. What an egg-citing time that was! Students named their little friends. Many of the students wanted to take them home, but I always shared that I was taking them to a neighbor who would take care of them. It takes about 26 weeks for the pullets to start laying; since they are young hens, they will be laying the smaller eggs. Have you ever found a double yolk? While the hens are getting their bodies in sync with laying, you may find an extra bonus. Laying hens typically lay an egg roughly every 24-27 hours and produce 200 to 300 eggs per year. As the hen gets older, her eggs will get larger. It was an egg-cellent time for these students to see a miracle in their classroom, from an egg to a chick. McDougall is the SNAP-Ed program assistant at the OSU Extension of Hancock County.

comments

Continue reading here:
Weekend: Elementary school classroom gets 'egg-cited' - The Courier