Mitosis: Anatomy of a Custom Keyboard – Hackaday

Ergonomic. Wireless. Low-latency. Minimalist. Efficient. How far do you go when you design your own open-source keyboard? Checking off these boxes and providing the means for others to do so, Redditor [reverse_bias] presents the Mitosis keyboard, and this thing is cool.

The custom, split as the namesake implies mechanical keyboard has 23 keys on each 10 cm x 10 cm half, and, naturally, a custom keymapping for optimal personal use.

Upper and lower PCBs host the keys and electronic circuits respectively, contributing to the sleek finished look. Key caps and mechanical switches were ripped from sacrificial boards: two Waveshare core51822 Bluetooth modules are used for communication, with a third module paired with a Pro Micro make up the receiver.[reverse_bias] spent a fair bit of time attempting to minimize the power consumption of the keyboard so it could be powered by a pair of coin batteries, giving it an estimated six month lifespan of daily use. These are pinched between the upper and lower boards by little dabs of solder and the slight spring tension of the boards themselves. However, a bit of de-soldering is required to change the battery.

Laser-cut adhesive neoprene adorns the base, proving a comfortable springiness, grip, and protection for the pins as well as cushioning from any debris on the desk. The final product has almost zero flex, has a low enough profile to negate the need for a wrist rest. If youre interested in building your own, [reverse_bias] has linked all the relevant files here.

Of course, one could always go the opposite way and opt for a more heavyweight option.

[Thanks for the tip, Tyberius Prime!]

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Mitosis: Anatomy of a Custom Keyboard - Hackaday

Anatomy of a Goal: Alan Gordon’s Game-winner – Massive Report

Welcome to the Anatomy of a Goal, where each week we dissect one goal (or near goal) from the previous weeks Columbus Crew SC match.

For match 16 of the 2017 MLS Season, we take a look at Alan Gordons 86th minute headed goal that put the Colorado Rapids up 2-1 as part of the win over Columbus Crew SC on Saturday.

Heres a look at the finish from the Rapids forward.

The Black & Gold once again gave up a late lead as Colorado striker Kevin Doyle tied the game in the 80th minute. While Columbus held a significant possession edge over the Rapids, Crew SC were ultimately unable to break down a stingy Colorado defense, and were unable to adapt to a sloppy high press.

It was difficult to decide which of this games three goals to review. Federico Higuains opener was the result of a fortunate deflection and Doyles equalizer was another breakdown by the Columbus defense. Gordons game-winner, however, shows why the Colorado striker was a fixture on multiple MLS Cup-winning teams.

The Rapids game-winner begins with midfielder Micheal Azira. Azira received the ball on a throw-in and is under very little pressure from Columbus, defending in two distinct banks. The Colorado midfielder has time to survey his options and take the ball at the Crew SC defense, a short pass to Mohammed Saeid or a cross-field switch to left back Eric Miller.

Azira goes for the most difficult option, and switches the ball to a totally unmarked Miller as the Black & Gold defense watch. The Rapids pushed multiple players up to the Columbus 18-yard box, forcing Harrison Afful to fall back and defend Colorado winger Josh Gatt.

Because Gatt forced Afful to defend further up the field, Miller has acres of space to carry the ball forward. Wil Trapp, seeing the space ahead of Miller, begins to close off the Rapid left backs movement.

As Miller and Trapp continue to move toward each other, Gatt checks back to his teammate. Afful sticks with the speedy Colorado winger, staying between Gatt and the goal.

As Trapp approaches, Miller makes the simple pass to Gatt, who is defended by Afful. Notice in this image and the following images that Afful gives Gatt space on the ball but stays between the Rapid winger and the goal. Afful is likely aware of Gatts reputation as a speedy player, and intelligently gives just enough space to keep Gatt from trying to beat him at speed.

Now, Gordons work begins. Highlighted at the top of the 18-yard box, Gordon is in the channel between Jonathan Mensah and Alex Crognale. Jonathan is currently occupied by Caleb Calvert. Gordon, who feasts on crosses, is likely trying his best to avoid the taller Crognale, and will switch places with Calvert.

Afful stays between Gatt and the goal, as Trapp shifts over to provide defensive help, keeping the Colorado winger about 35 yards from the goal. You can see that Crognale is aware of Gordons positioning, but is giving the Rapid striker a yard or two of space, while Calvert continues to occupy Jonathan.

Affuls goal in this defensive sequence is to prevent Gatt from going around him or to force a cross from a difficult distance or angle. The Crew SC right back, with the help of Trapp, does both of those things, forcing Gatt to send in a long cross.

In the box, Gordon has backed up directly into Jonathan. Crognale will not really mark anyone on this play.

As Gatt prepares to cross the ball into the box for the game-winning assist, lets take a closer look at Gordons move to get separation from Jonathan before we break it down.

In the left-most magnifier, Trapp and Afful have closed down Gatt, and force him to make a difficult, though successful, cross. It is difficult to see Gordon, but you can just make out his right leg to the right of Jonathan. Here, Gordon and the defender are fully engaged, with the Black & Gold center back right on the Rapid strikers back.

As Gordon prepares for a cross, he gets just to the right of Jonathan. The Colorado striker will engage Mensah and then push the Columbus center back off of him, creating space and very briefly putting Jonathan off balance.

Gatts difficult ball leaves his foot while Gordon extends his left arm, beginning to separate himself from Jonathan.

As the claret-highlighted ball travels toward his head, Gordon has fully knocked Jonathan off balance. The Crew SC defenders chief mistake here is letting Gordon get between him and the goal. On Jonathans goal-side shoulder, Gordon can more easily read the pass and clear up anything on the back post. As Jonathan saw Waylon Francis come to mark Calvert, he should have immediately repositioned himself between Gordon and the goal.

Now, Gordon can gauge the trajectory of the ball while Jonathan is forced to recover and decide whether to cover the Rapid striker or to attempt to play the ball. Zack Steffen is caught in a difficult place between attempting to defend a headed ball and trying to grab the ball out of the air. As Steffen gains more experience, he will have to make a much quicker decision on whether to play the shot or the cross.

Jonathan decides to jump in an attempt to either play the ball or distract Gordon, but all he does is get in the way of his goalkeeper. Steffen is blocked by Jonathan and Gordon has a perfect view of the balls path...

...and is able to head home the game-winner by barely jumping.

On video, you can see that Gordon gets so much separation that he barely has to jump in order to nail the game-winner.

Findings:

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Anatomy of a Goal: Alan Gordon's Game-winner - Massive Report

Can You Identify Each ‘Grey’s Anatomy’ Season By Its Opening Shot? (QUIZ) – Wetpaint

Credit: ABC

Think you know the lives of the Grey Sloan docs forwardand backward? Well find out!

For this Greys Anatomy quiz, you have to match each season with its very first shot or, at least, the very first shot with a series regular actor.

Which season started off on a shot of Jo Wilson? Which one kicked off with Derek Shepherd behind the wheel? Which three seasons began with Meredith Grey waking up? You tell us!

Greys Anatomy returns for Season 14 this fall on ABC.

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Can You Identify Each 'Grey's Anatomy' Season By Its Opening Shot? (QUIZ) - Wetpaint

11 Indefensible Izzie Stevens Moments on ‘Grey’s Anatomy’ (PHOTOS) – Wetpaint

Remember Dr. Isobel Stevens? That Greys Anatomy character who abruptly left the ABC hit seven seasons ago amid a flareup of behind-the-scenes drama?

Izzie did a lot of things right funded the clinic, gave her biological daughter a bright future, made Alex a better person, etc. but whats the fun in covering those?

No, today were talking about all her professional and personal missteps, from frivolous to frightful. Check out the gallery here to see 11 of them, presented chronologically.

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No wonder no one wanted to break bread together. Luckily for her, Burke swooped in to save the day and the roast turkey.

Looks like Santa threw up in here, George remarked.

Forget that transplant patient higher on the donor list, Izzie is in love! So she cut her paramours LVAD wire to put him first in line for a new heart.

Denny ultimately kicked a bucket, and his $8.7 million fortune went to Izzie. She kept the check on the fridge for a long time, and we pulled out our hair for a long time.

The Greys writers couldnt stop trying to make Gizzie happen, so for much of Seasons 3 and 4, we had to watch the characters fumble toward the realization they had zero sexual chemistry.

Denny appeared as a ghost to get Izzie to realize she had cancer but not before convincing Izzie to have sex with him.

Worse yet, she was involved with Alex at the time. (But is ghost sex cheating, technically?)

When Izzie told Cristina about her cancer diagnosis, Cristina pulled a lot of strings to get her a date with the best oncologist in Washington state, an appointment that Izzie brushed off. Why, girl, why?

Finally, to everyones relief, Izzie came around and accepted treatment.

This brings gallows humor to a whole new level. (Secretly, though, we love it.)

We get that Izzie had just had a brush with death, but making a medical error so grave that it costs a kidney transplant patient her spot on the donor list? Thats amateur hour for real.

Richard fired Izzie for that blunder, and she incorrectly assumed Alex was involved and left him. Yes, she left her own husband with nothing but a Dear John letter in his locker.

Izzie came back a couple of times that season but never achieved any semblance of closure with Alex before she vanished for good. Is she in Seattle? Did she get that job in Tacoma?

Well never know, because Katherine Heigl was desperate to leave Greys and Shonda Rhimes has never forgiven her.

Remember Dr. Isobel Stevens? That Greys Anatomy character who abruptly left the ABC hit seven seasons ago amid a flareup of behind-the-scenes drama?

Izzie did a lot of things right funded the clinic, gave her biological daughter a bright future, made Alex a better person, etc. but whats the fun in covering those?

No, today were talking about all her professional and personal missteps, from frivolous to frightful. Check out the gallery here to see 11 of them, presented chronologically.

Add your email to get news about your favorite shows or celebrities

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11 Indefensible Izzie Stevens Moments on 'Grey's Anatomy' (PHOTOS) - Wetpaint

‘Grey’s Anatomy Season 14’ spoilers: Dr. Robbins deals with another heartbreak – Blasting News

It's the all new "#Grey's Anatomy" Season 14 coming this fall, and Dr. Arizona Robbins (#Jessica Capshaw) still hasn't found the one. Trust everyone to have concluded Dr. Eliza Minnick's (Marika Dominzyck) role in her life as the former's love interest on the show. In the final episode of "Grey's Anatomy" Season 13, Eliza got fired hence speculations that it could be the doctor's character exit from the show.

Dr. Eliza Minnick, a certified orthopedic surgeon, arrived at Grey Sloan Memorial Hospital as a hired consultant by the hospital. She was a great doctor that is never welcomed by the resident doctors of Grey Sloan.

She became Arizona's love interest after she made clear she's interested in women. Despite Eliza's level-headed nature, Arizona was challenged and gave their budding relationship a try.

The show's Season 13 featured all the reason why Dr. Arizona Robbins and Dr. Eliza Minnick are the perfect pair, until the latter received the news that she's fired from the hospital. Surprised by the sudden decision, Robbins can't offer any help to Minnick who is bound to leave the hospital anytime and worse, say goodbye to their relationship.

Arizona Robbins was formerly married to Dr. Callie Torres (Sara Ramirez), also an orthopedic surgeon at Grey Sloan Memorial Hospital. During their marriage, Robbins hooked up with another doctor that turned everything upside down.

After their divorce was finalized, Torres character left for New York to pursue a better medical practice, and that's how her character on "Grey's Anatomy Season 12" was let go.

Shortly after leaving the show Sara Ramirez revealed she's bisexual, but that has not changed the fans' eagerness to have her back on the show. In fact, after Eliza Minnick is fired from Grey Sloan, fans are hopeful; it will pave way to the return of Callie Torres character. Show runner Shonda Rhimes has not given any formal statement about the character of Eliza Minnick, nor her firing from the job constitutes to leaving the show.

Meanwhile, ABC has confirmed the return of "Grey's Anatomy" Season 14 this fall and expect an all new story in the lives of Grey Sloan Memorial Hospital doctors. Watch Meredith Grey (Ellen Pompeo), Miranda Bailey (Chandra Wilson), Alex Karev (Justin Chambers) and the rest of the cast perk up your Thursdays at 8 PM on the ABC channel. #Grey Anatomy

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'Grey's Anatomy Season 14' spoilers: Dr. Robbins deals with another heartbreak - Blasting News

Allergy/Immunology articles: The New England Journal of …

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Deciphering The Immunology Combo Avalanche – Seeking Alpha

As the nearly 800 currently ongoing studies involving anti-PD-(NYSE:L)1 agents combined with other approaches speed towards readout investors will be faced with a tough question: how precisely to interpret the overwhelming amount of data generated.

The issue took centre stage at a panel discussion at today's Sachs Associates Immuno-oncology Forum on the sidelines of the Asco meeting. It will be one of several things the industry will grapple with, though it is by now abundantly clear that there is no stopping the combo study runaway train.

That fact was illustrated in a report just published by EP Vantage, which showed that the absolute number of anti-PD-(L)1 combo trials under way - with numerous mechanistic approaches - had surged nearly fourfold since November 2015 to reach 765 in April.

Dr James Mul, from the Moffitt Cancer Center, told the Sachs conference that it was hard to imagine just how rapidly these trials were being conducted. In terms of subjects enrolled, he cited data showing that there were now over 250,000 patients in active immuno-oncology studies.

"But there will be no clear-cut direction as to where combo studies are heading until about 2019," he said. "There's still a way to go before we can make clear-cut decisions."

John Beadle, chief executive of Psioxus, whose oncolytic virus enadenotucirev is being combined with Bristol-Myers Squibb's (NYSE:BMY) Opdivo, called the expected surge of data an "exponential avalanche of information".

Still, most of these studies are too early to involve randomisation, and many are not designed to answer the simple, head-to-head question of whether A plus B is better than A or B alone. And, while it is clear than many combos will not work, what yardsticks should investors use to determine whether a combination has actually given an incremental benefit?

The panel suggested that one aspect of particular relevance should be to look at whether a study involves subjects who have already failed on a checkpoint inhibitor, or those who have shown resistance to immuno-oncology in general. Signs of efficacy in these patients would clearly be of interest.

IO-IO or back to basics?

Paul Rennert, chief executive of Aleta Biotherapeutics, who was co-chairing the panel with Dr. Mul, drilled down into the changing expectations behind the various checkpoint combination approaches.

He admitted to having been one of the people who two or three years ago had made much of the potential of combining immuno-oncology with immuno-oncology, assuming that novel targets like Ox40, GITR, Tim3, Vista and others were going to raise immune responses strongly and usher in a new wave of post-PD-(L)1 agents.

"We thought we were going to get response rates up. We're not seeing that yet," he admitted. "Perhaps it's too early."

On the other hand, perhaps it is checkpoint inhibitor combinations with more traditional approaches, such as small molecules or even simple chemotherapy, that investors should pay attention to. The surge in chemo combo studies was another key finding of the EP Vantage report.

This issue could feed into other important areas such as pharmacoeconomics: a chemo combo approach would clearly be cheaper than one combining two IO agents.

At a separate Sachs Forum discussion focused on deal-making, Timothy Herpin, head of UK transactions at Astrazeneca (NYSE:AZN), said there would likely be continued interest in non-IO mechanisms, but that these would play out in combination with an IO backbone.

Guillaume Vignin, head of IO licensing at Merck KGaA (OTCPK:MKGAF) (OTCPK:MKGAY) said it was too early to call the non-IO combo approach a trend. "But there are exciting data to be published," he said. "The two will be working together - it will not all be about IO-IO."

If one thing is certain, however, it is that data will come thick and fast, and this will affect the way deals are done. The important thing seems to be just to get deals signed to get the combos into the clinic, and generate data, as quickly as possible, said Mr. Herpin.

"Once you have data we can work through the [deal] complexity," he added.

Editor's Note: This article discusses one or more securities that do not trade on a major U.S. exchange. Please be aware of the risks associated with these stocks.

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Deciphering The Immunology Combo Avalanche - Seeking Alpha

Immunoassay and Live Cell Analysis Solutions Presented at IMMUNOLOGY 2017 – SelectScience

The Annual Meeting of the American Association of Immunologists (AAI) is one of the largest annual gatherings of immunologists worldwide. This years meeting, IMMUNOLOGY 2017, held in Washington, DC, USA, saw immunologists from around the world discussing breakthroughs across the full spectrum of topics in the field, while exhibitors displayed the latest technologies for cutting edge techniques.

During the event, MilliporeSigma, a business of Merck KGaA Darmstadt, Germany, presented a range of new solutions for immunologists, including a series of T Cell multiplex assay kits for low-level cytokine detection in small samples volumes, and the CellASIC ONIX2 Microfluidics System for real-time control and manipulation of cellular environment for live cell analysis. Watch the video interviews and presentation to learn more about these innovations and how they can help to advance your immunology research.

New High-Sensitivity Immunoassays Panels Detect Picogram Level Cytokines

Robert Keith, R&D Scientist, MilliporeSigma, introduces three high-sensitivity MILLIPLEX MAP panels to help researchers detect low levels of multiple cytokines in small amounts of sample: the Human High Sensitivity T Cell Magnetic Bead Panel (in both 96-well format and a new 384-well format) and the new Mouse High Sensitivity T Cell Magnetic Bead Panel in 96-well format. Both the human and mouse high-sensitivity panels can detect picogram levels of cytokines in just 25 L of sample for up to 21 or 18 critical cytokines, respectively.

Robert Keith introduces three new high-sensitivity MILLIPLEX MAP panel

Robert Keith highlights the benefits of the new T Cell multiplex assays for immunologists

Automated Cell Culture for Dynamic Analysis of Cell Function in Real Time

Dr Amedeo Cappione, Senior Scientist, MilliporeSigma, explains how the microfluidics-based CellASIC ONIX2 System offers precise real-time control of media perfusion for cell researchers who need a highly controllable and manipulatable cellular environment and the ability to conduct semi-automated, repeatable long-term experiments while continuously collecting quantitative image-based data.

Dr Amedeo Cappione explains how the CellASIC ONIX2 System works

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Immunoassay and Live Cell Analysis Solutions Presented at IMMUNOLOGY 2017 - SelectScience

Security Awareness: How to Make Your Weakest Link Part of Your Defense – Security Intelligence (blog)

While the origin of the recent WannaCry exploit is still under investigation, there is no doubt that humans remain the weakest link in the chain of defense against cyberattacks.

According to the IBM X-Force Threat Intelligence Index, human factors play a major role in various types of attacks. While its easy to blame users, many overlook the fact that these individuals can be turned into a valuable asset for an organizations defense capabilities. A well-aligned, orchestrated security awareness program can unlock this potential, but its success depends on practices beyond the typical security domain namely, psychology, communication and culture.

The traditional approach is to define an acceptable use policy and require users to sign it. This may help to transfer some responsibility to the users, but it does not make an organization more secure at the end of the day. Making users part of your defense requires more than a warning finger; its about changing behavior.

While the elements of a security awareness program depend on an organizations structure, business and culture, human behavior change is based on fundamental principles. The first tenet urges security leaders to include users in the mission instead of treating them as a risk. To be part of the mission, individuals need to understand it, recognize risky situations and react in a proper manner.

Furthermore, successful awareness programs involve other such as human resources, legal, marketing and physical security that often have mutual interests. These departments can collaborate to make security awareness efforts mandatory and contribute valuable resources such as funding and distribution tools. Human resources can build security awareness into onboarding and performance management processes, for example.

Human factors contribute in many ways to security risks, from dealing with phishing emails to handling sensitive data and interacting with other company assets. It is simply impossible to address all these issues at once. Instead, security leaders should focus on the most severe behaviors from a risk management perspective.

This approach will help to keep messages clear and prevent users from viewing security as an annoyance. Users are confronted with many daily obligations and simply dont have time to wait for another set of tasks. Therefore, you should split your messages into small portions, assign tasks that take no longer than 15 minutes and distribute the content over a period of time. This approach also makes it easier to keep software up to date.

People consume information in different ways depending on their background, profession and generation. Successful programs incorporate a variety of channels to make the message stick, including newsletters, posters, games, news feeds, blogs, simulated phishing attacks and more. In general, the most participatory efforts appear to have the most success.

If you invest time and money to strengthen your security program, you should be able to report its effectiveness to management and stakeholders. The only way to do this is to collect metrics in advance of awareness efforts. Without this baseline, it is hard to demonstrate success.

Security awareness metrics can include surveys to gauge attitudes and more statistical values such as results from simulated phishing attacks before and after awareness training. It might also be helpful to examine the number of security-related incidents. Measurable improvements, in any aspect of security, will help justify the program and, eventually, obtain additional funding and support.

Watch the On-Demand Webinar: Orchestrate Your Security Defenses

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Security Awareness: How to Make Your Weakest Link Part of Your Defense - Security Intelligence (blog)

Men, women show similarities, differences – Hays Daily News

This is the ninth article in a series about similarities and differences between men and women.

Q: How do the differences between men and women complicate male/female relationships?

A: In a study by psychologist Dario Maestripieri and his colleagues, the study concluded men and women belong to different species. The following information, in an article by Agustin Fuentes, refutes that conclusion. Fuentes has a bachelors degree in zoology and advanced degrees in anthropology. He is a professor of anthropology at the University of Notre Dame.

In his critique of the study, Fuentes elucidates three main problems. First, gender and sex are used interchangeably and they are not interchangeable. Second, the evolved differences in women and men are not measured. Third, relevant anthropological and biological datasets are disregarded.

Fuentes points out sex and gender are different. Sex is the biological state measured by the content of chromosomes in addition to various physiological and developmental measurements. Gender, on the other hand, consists of the roles, perceptions and expectations that society has for the sexes.

The majority of societies have two genders on the masculinity-femininity spectrum. Some societies do have more. The two concepts are interrelated but not the same. People are born with a sex but acquire gender. Within societies, there is great diversity between individuals and sexes regarding how sex and gender interact in personality and behavior. Although there is a lot of literature about that subject, many researchers, whose only interest is definitive distinctions between women and men, choose to ignore that literature.

Measuring evolutionary differences in behavior within a species is difficult. There are at least two methodological approaches that are necessary to do that. First, the assessments have to be comparative with more than one population of the species of interest. Secondly, the traits for measurement have to be linked some way with the heritable elements of human physiology or behavior that have an effect on overall fitness. These traits must be assessed by measures that are both accessible and replicable among different populations in the species.

In their study, Del Giudici and associates used a large sample of questionnaires from mostly white, educated Americans. In relation to the global diversity present in culture structure, this sample from Del Giudici and associates is limited and is not a comparative, evolutionary sample of the species.

The data from the Del Giudici and associates assessments of 15 personality variables are laden with cultural meanings and contexts that are not easily transferable across societies in time and space. Moreover, these personality variables are difficult, or impossible, to connect quantitatively to all aspects of human physiology, neurology or other structured, identifiable targets for natural selection. Furthermore, their personality traits are not static traits, but are dynamic traits that are fluid over a persons lifetime.

When discussing evolved differences in behavior between females and males, no one can make a statement like, When it comes to personality, men and women belong to two different species, without stating the biological reality that men and women are the same species. There are not consistent differences in brains between the sexes.

There is considerable overlap in physiological function. Both sexes engage in sexual behavior in essentially the same patterns. The sexes also overlap extensively in most other behaviors. There are interesting re-occurring differences, especially in patterns of aggression and some physiological correlates of reproduction, body size and muscle density. Anthropological and biological studies consistently demonstrate dynamic flexibility and a complex biocultural context for human behavior. These studies are especially true for gender.

Del Giudici and associates and Maestripieri are countering Janet Shibley-Hydes gender similarities hypothesis because they believe men and women are more different than similar. There are many valid points of disagreement regarding Shibley-Hydes paper. Del Giudici and associates name a significant methodological point of contention, but fail to provide an assessment and analysis of the overall data and meta-analysis used by Shibley-Hyde.

Something about trying to prove men and women are different, or the same, makes people somewhat irrational. There are no clear or easy answers about why people do what they do. There also are no clear answers about why men and women have problems getting along sometimes. Those researchers who ignore that data about how men and women are similar and different and approach sex and gender from a one-dimensional approach are practicing poor science.

Augustin Fuentes is the scientist upon whom this article is based. He contends there is an enormous dataset about how men and women are similar and different that responsible scientists cannot ignore.

Next weeks article will discuss the aging process in men and women.

Judy Caprez is professor emeritus at Fort Hays State University.

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Men, women show similarities, differences - Hays Daily News