Release: Sophia Genetics using AI in liquid biopsies to accelerate early detection of cancer – Access Ai

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Sophia Genetics, aleader in Data-Driven Medicine, has unveiled a new AI-powered solution for liquid biopsies to help with the detection of cancer and to monitor treatment.

This new application, unveiledat the 2017 Annual Meeting of the American Society of Clinical Oncology (ASCO), taps the analytical power of the companys artificial intelligence, SOPHiA, to help clinicians diagnose, treat, and monitor cancer earlier and more effectively by looking at circulating tumour DNA (ctDNA), or circulating tumour cells (CTC), contained in patients liquid samples such as blood, urine, and cerebral spinal fluid.

Compared to tissue biopsies, liquid biopsies allow clinicians to perform analysis of solid tumours and hematological malignancies at various time points to detect tumour progression and monitor treatments effectiveness. This new approach also represents a faster and less invasive alternative for patients.

The lack of a standardised analytical solution able to take into account different samples stability and low ctDNA levels has for a long time been a significant barrier to the widespread adoption of liquid biopsies in hospitals. SOPHiA solves these challenges by offering a standardised DNA analysis approach to liquid biopsy testing, built upon the network of 300 hospitals from 50 countries already using SOPHiA for genomic data analysis. Even with low ctDNA levels, SOPHiA provides indispensable insights into tumours profiles, straight from liquid samples.

One of the first users of SOPHiA for liquid biopsies, Prof. La Payen-Gay, co-investigator of the CIRCAN (CIRculating CANcer) program at the Hospices Civils de Lyon Laboratory, based in Lyon, France, explained, SOPHiA helps save precious time and resources and serves as an excellent benchmark for our laboratory as it detects and validates a more comprehensive list of variants. The companys analytical platform, SOPHiA DDM, is user-friendly and easy to navigate, making it possible for a user to be hands-on from benchtop to variant calling.

Speed and precision

Rather than waiting for months to detect changes on an imaging scan, SOPHiA allows clinicians to monitor a tumours progression with remarkable precision from a simple blood test. Faster and more accurate analysis eliminates undue anxiety resulting from biased answers and unclear response to heavy treatments, making regular status-check less stressful and painful for patients. SOPHiAs application for liquid biopsies is also available for clinical trials, making it possible to identify the patients most likely to benefit from new treatments.

To facilitate the interpretation of all the genetic variants detected by SOPHiA in ctDNA, the analysis results are presented in the companys OncoPortal, an interface dedicated to solid tumours and hematological malignancies, which experts can access on the companys online analytical platform, Sophia DDM. OncoPortal flags associations between human gene variants, disease causality, progression, drug efficacy, and toxicity to help the clinicians better leverage the data analysed by SOPHiA in order to provide personalised care to patients.

Jurgi Camblong, CEO and co-founder of Sophia Genetics, commented, By applying SOPHiAs state-of-the-art analytical power to liquid biopsies, clinicians can now leverage the collective intelligence of over 300 hospitals to help better diagnose, treat, and monitor cancer in a less invasive manner for patients. Now supporting tumor testing directly from blood samples with ctDNA, SOPHiA has the potential to benefit thousands of patients lives by giving clinicians access to the most advanced technology for cancer diagnosis and identification of successful treatments.

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Release: Sophia Genetics using AI in liquid biopsies to accelerate early detection of cancer - Access Ai

Using genetics to make best use of wind and solar in electrical systems – ScienceBlog.com (blog)

Scientists from the University of Geneva are using the rules of genetics to better understand how to incorporate wind and solar power into the current electrical grid to produce a renewable power system. The researchers published their study in IEEE/CAA Journal of Automatica Sinica (JAS), a joint publication of the IEEE and the Chinese Association of Automation.

Integration of intermittent generation into the electric network is a challenging task, as supply must always match demand, said Tim Mareda, a doctoral student at University of Geneva and an author on the paper.

The researchers examined the problems of wind and solar power reliability, storage, and delivery to areas with high demand for power across a large-scale area, such as Europe. Mareda and his team used Europes existing transmission map to create a grid of equally sized and spaced cells. They then simulated the mismatch between power generation and use every hour from years of electricity consumption data, and also estimated typical solar and wind generation.

To process this information, the researchers created an algorithm with set parameters, including the grids physical reach, the produced power of the renewable units, the storage capacity, and the ability of the system to charge and discharge power.

Designed to optimize the power exchange and use of available solar and wind power, the algorithm is derived from biology. Genes mutate, or share information, or select a specific output, to solve biological problems. It may not be the best solution for the entire body, but it provides a good solution for the individual genes. Mareda and his group used the same principles to optimize power generation and dispatch decisions through the simulated grid system, and they found it worked well.

From a technical perspective, and within our model assumptions, expanding the spatial distribution of weather-driven power sources is an effective way to manage intermittent generation, said Mareda. He noted that his teams study results are specific to Europe, but their approach can be used to study intermittent generation in any location.

Mareda and team plan to explore how wind and solar power systems could be coupled between different regions as a part of a large-scale renewable integration strategy.

Long term planning is crucial when evaluating options, Mareda said. Distributed generation harvested from wind and solar power can expand through both locally defined integration strategies and through large-scale power system designs. The paradigms are not mutually exclusive, and all options should be carefully considered to achieve a successful transition to a fully sustainable power system.

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Fulltext of the paper is available:

http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7894136 http://html.rhhz.net/ieee-jas/html/20170213.htm

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Using genetics to make best use of wind and solar in electrical systems - ScienceBlog.com (blog)

Royal Palm valedictorian plans to study biochemistry – Palm Beach Post

MEET YOUR NEIGHBOR: Carlos Romagosa, 17

If there is one common theme among high school valedictorians, its the fact that, when they look back at their high school careers, they often find something they think they could improve upon.

Despite his 3.98 (5.33 weighted) GPA and the achievement of finishing high school ranked No. 1 in his class, Carlos Romagosa is no different.

I was doing it for the wrong reasons, Romagosa said of his quest to become valedictorian of Royal Palm Beach High. I should have been doing it because it was something that could make me a better student and better person. Instead, when I look back, I was just doing it because it was an academic achievement. I wanted to be No. 1 and that was it.

Regardless of the reasoning, Romagosas is an amazing achievement. Especially when you consider the only B that figured into his GPA was one he received before he began high school.

I had always wanted to take AP calculus so I thought Id take on online geometry class before my freshman year began, he said. That was my B. That taught me never to procrastinate.

Of course, he later took the geometry class in person and got an A.

Avoiding procrastination may have been the biggest life lesson that Romagosa took from high school. Applying himself to get work done turned out to be the key to his rising from No. 2 after his sophomore year to No. 1 when he graduated.

During his junior year, Romagosa took only Advanced Placement and Advanced International Certificate of Education courses as he pursued his quest to become valedictorian.

I just had to start taking my time on things. Take care with everything I do and do everything well. Challenge myself, he said. I really wouldnt change a thing. Everything that happened to me has molded me to be in this position. But I would tell students to try new things. Try things youre uncomfortable with as well.

World history taught him that lesson, Romagosa said. He took the class not thinking he would enjoy it, but it ended up being one of his favorite subjects in high school. So much so that, after his trip to the Dominican Republic later this summer, he has places like Africa and Europe on his radar as future destinations.

Romagosa will head to Florida International University, where he will pursue a degree in biochemistry. The hope is to soak up the culture Miami has to offer and finish college with the goal of working in a lab.

I want to study the cellular membrane, he said. See how we might be able to apply photosynthesis to other applications.

Q&A

What are your hobbies?

Reading, writing, I love the game of basketball. Im not good at it but I try to play it. I love watching it. My favorite team is the Golden State Warriors, but Im not a bandwagon fan, Ive been watching them since 2012.

What would you do if you were invisible for a day?

I would love to go into our government and learn all their secrets. Im just so curious. I want to know what theyre hiding from us. What are they keeping from us?

If you could have dinner with anyone in history, who would it be?

This is kind of hard for me, so Im going to say its a tie between FDR and JFK. They were both so progressive, so ahead of their times. Especially FDR and how he could inspire hope in such a weak time in our history. And JFK, every time you see him in a debate, he just looked so lively and full of life.

What is the best advice you ever received?

Be yourself. Its short and sweet. I heard it a lot, but I think the first time it was from a manager at Chick-fil-A. He told me the most important advice is to be yourself. Dont get caught up with people.

What event in history would you have liked to have witnessed?

The rise of the Romans. They were such a dominant group of individuals. I like that when they conquered enemies, they learned their enemies strengths to make them stronger.

What is your favorite childhood memory?

Going to Disney World. There is nothing that beats that for the first time. I was 4 or 5, but I remember Mickey Mouse and all that. It was so cheerful and bright. Universal is exciting, but Disney has that special thing to it.

Who is your hero, someone who inspires you?

Hemingway. He struggled with all these mental breakdowns, but fought through it all and succeeded. For a period of time he pushed through it and excelled. He would write for hours and hours on end. Then he would go out and drink.

What is something most people dont know about you?

I think everyone views me as very serious, but I have a really good sense of humor. All my friends know. I mean, nerds can go crazy too!

What three things would you bring with you if you were stuck on a desert island?

A desalinization machine, a beach umbrella, and a book just to relax. Any book would work, but if I could list one, I would say The Old Man and the Sea, since Im stuck on an island and all.

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Royal Palm valedictorian plans to study biochemistry - Palm Beach Post

The anatomy of a capsize: how did a multi-million dollar America’s Cup boat end up in the drink? – Telegraph.co.uk

'The bear away'

Both teams are now having to make what is known as a 'bear away' in order to cross the start line within the designated boundaries. Because you can't sail a boat directly into the wind, you have to tack or gybe, essentially zig-zagging your way from A to B. As you execute each turn you must bear away from the direction that the wind is coming from, but this can be destabilising if you try to make too sharp or too hasty a turn.

As you can make out from the second freeze-frame, New Zealand have been forced a little wider and are closer to the start line when they begin to bear away. That means the angle on their turn is significantly more acute.

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The anatomy of a capsize: how did a multi-million dollar America's Cup boat end up in the drink? - Telegraph.co.uk

Anatomy of a Stalled Transfer: Mohamed Salah to Liverpool – The Liverpool Offside

Mohammed Salah to Liverpool was a done deal just a few days ago. Liverpool had made a 28M bid and though it had been rejected by Roma, they were expected to settle on a fee in the neighbourhood of 35 and, with Salah having already agreed personal terms with the club, to push it over the line in short order.

Then came whispers that a second offer wasnt coming, that Liverpool were considering Lazios Keita Balad, that Roma werent willing to budge at all on their 43M asking price. Today, Sporting Lisbon winger Gelson Martins has appeared out of nowhere as the next supposed winger transfer target in place of Salah.

Its perhaps easy to be uneasy, as a Liverpool fan, given how often the club have seemed to dither, to try to negotiate down to the last penny only to then lose a player they had seemed certain of signing. In this case, though, fans should probably take a deep breath. They should feel confident that, in the end, Salah will arrive.

Exhibit A in that is that Roma, put simply, need to sell. Things are looking bad for the Giallorossi on the FFP front for the current financial period, and they desperately need a major sale before the end of Junebefore the transfer window even officially opensto balance their books and avoid likely UEFA punishment.

Roma are a motivated seller, and depending on how the deal was structured, even Liverpools initial 28M offer could be enough to balance the books for them. If another high value player was set to be sold, or if Salah himself was in wide demand, it might change the equation. Right now, though, neither of those things are true.

Liverpools interest in Salah represents Romas bestand perhaps even onlychance of balancing the books. And were getting awfully late for another club to swoop in and offer Roma what they need, relieving the pressure on them to sellor giving them significantly more for Salah than Liverpool would be willing to.

That brings us to Exhibit B, a lack of other serious suitors. Salah, for all the goals he scored last season, wouldnt fit at either Manchester City or at Tottenham. He wouldnt be likely to consider a Chelsea return or a reunion with Jos Mourinho. Hes not at a level that would attract Bayern or Barcelona or Real Madrid.

That leaves Arsenal, potentially, as a reasonable alternative. A club big enough to just maybe change Salahs mind on where he wants to end up next season while having the financial wherewithal to pay Roma what they need and want. That, then, is a very, very short list. And as yet there has been no sign of any Arsenal interest.

Even if there wasand it wouldnt be surprising to hear rumours of interest out of Italy this week given they would be in Romas interestwith a relationship already established with the player, with Champions League football and Jrgen Klopp on offer, Liverpool would have to feel confident in winning the day.

Roma need to sell. Liverpool are the only serious suitor. It would be financially reckless in the circumstance for the English club to not push for a better deal. In the meantime, there will be leaks from the Liverpool end of interest in other playerssignals to Roma that they might miss out on their best chance to balance the books.

There may also, in the coming days, be rumours from the Roma end of Arsenal interestat least if Roma have done their homework; if they havent it will be rumours of City or Chelsea interest. And there will be papers in Portugal and perhaps elsewhere who sense the opportunity to feed their own stories into the mix.

In the end, though, no matter the rumours or the reports or the posturing, if Salah is currently Liverpools top wing targetand all signs still point to him being thathe will end up at Anfield. In the meantime, fans will just have to try to stay calm, knowing the club are doing the right thing pushing for the best deal.

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Anatomy of a Stalled Transfer: Mohamed Salah to Liverpool - The Liverpool Offside

Anatomy of a frustrating Colorado Springs traffic jam: U.S. 24 and … – KKTV 11 News

COLORADO SPRINGS, Colo. (The Gazette) - After a day of four-wheeling, fishing or other frolicking in the mountains west of Colorado Springs, an unwelcome surprise awaits many motorists heading back to the big city.

A traffic jam.

A recent timing change to the signal at eastbound U.S. 24 and 31st Street at times produces a line of vehicles stretching west to the Manitou Springs exit.

"We realize it's causing a little backup," said Michelle Peulen, a spokeswoman with the Colorado Department of Transportation.

Morning and evening rush hours and weekends are the worst, when drivers can sit through several light cycles before being able to move through the intersection.

"Summer is just beginning, so I'm sure the complaints will heat up," said Crystal Maez, who works at The UPS Store in the nearby Red Rock Canyon Shopping Center. "It always gets busy."

It could be a while before the situation is remedied.

"We're pretty much stuck with what we've got," said Kathleen Krager, the city's senior traffic engineer.

Until needed improvements happen, that is.

Safety concerns led CDOT, which is responsible for the signal, and the city of Colorado Springs, which maintains the signal, to limit the left-turn arrow.

Previously, the arrow turned green, then flashed yellow, allowing motorists to continue turning left if there was no oncoming traffic.

But the intersection has been the site of at least two fatalities in recent years, said Peulen, along with other traffic problems.

For the left-turn movement only, 14 crashes with 21 injuries and two fatalities occurred from January 2011 to December 2015, she said. "We've seen a large number of crashes at that intersection."

Drivers' view of oncoming vehicles is blocked by a median, Krager said.

"The real improvement we're trying to make is to get the left turns to align with each other so you have an easier time seeing around the opposing lane," she said.

"It requires taking out the median, and there's an elevation change between the lanes, so it's not as easy as most projects will be."

The state's long-range plan calls for a longer left turn lane on U.S. 24, so cars don't pile up and block the through lane.

But, "It will be 2018 to 2019 before that project is underway," Peulen said.

The left-turn arrow is now 27 seconds long, up from 18 seconds of solid green and then flashing yellow.

"We've made it as long as we can make it," Krager said. "We still have to allow pedestrians to cross that street, too."

A flashing variable CDOT message board warns drivers that eastbound through traffic on U.S. 24 should stay in the right lane, to avoid getting stuck in traffic trying to turn left.

"It's an intermediate fix," Peulen said. "We're doing it to prevent crashes and any more potential fatalities."

The turn arrow likely won't ever go back to the way it was, she said.

Krager recommends patience. "We want people to be aware there could be backups in the through lane and choose alternative routes," she said.

The city traffic division is monitoring the intersection by camera.

"We view it every morning to look at the backups," Krager said. "We're keeping a close eye on it."

More vehicles than usual have been turning onto 31st Street from eastbound U.S. 24, trying to avoid the massive construction work at Interstate 25 and Cimarron Street and along West Colorado Avenue. The interstate work should be done later this year; the Colorado Avenue project could take three years to complete.

"We hope people will use the Cimarron interchange," Krager said. "It's not a bad choice," as construction winds down.

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Anatomy of a frustrating Colorado Springs traffic jam: U.S. 24 and ... - KKTV 11 News

From the June issue: The anatomy of Southfin Southern Pok’s Luau bowl – 225 Baton Rouge

Southfin's Luau bowl. Photo by Collin Richie

Eighteen months of planning went into creating the new eatery Southfin Southern Pok, a concept by the City Pork Restaurant Group that riffs on the beloved raw fish salad of Hawaii and other Pacific islands. Poke restaurants that reinterpret the indigenous dish first started popping up in large cities around five years ago and have since made their way across the country.

Baton Rouges response has completely blown our minds, says partner Stephen Hightower. We came at this really wanting to create a healthy lifestyle concept rooted in fresh ingredients, and people are getting it.

One of the menus rising stars, says Hightower, is the Luau, a tropical-themed bowl anchored by fresh Gulf tuna and shrimp. The bowls 11 ingredients arent there by accident. We really took time to make sure the profiles in all the bowls work well together, Hightower says. Its easy to get it wrong.

Read on for the full story on all the flavorful and unique components of Southfins Luau bowl.

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From the June issue: The anatomy of Southfin Southern Pok's Luau bowl - 225 Baton Rouge

Warren Alpert Foundation Honors Five Pioneers in Cancer Immunology – Harvard Medical School (registration)

The 2017Warren Alpert Foundation Prizehas been awarded to five scientists for transformative discoveries in the field of cancer immunology.

Collectively, their work has elucidated foundational mechanisms in cancers ability to evade immune recognition and, in doing so, has profoundly altered the understanding of disease development and treatment. Their discoveries have led to the development of effective immune therapies for several types of cancer.

The 2017 award recipients are:

The honorees will share a $500,000 prize and will be recognized at a day-long symposium on Oct. 5 at Harvard Medical School.

The Warren Alpert Foundation, in association with Harvard Medical School, honors trailblazing scientists whose work has led to the understanding, prevention, treatment or cure of human disease. The award recognizes seminal discoveries that hold the promise to change our understanding of disease or our ability to treat it.

The discoveries honored by the Warren Alpert Foundation over the years are remarkable in their scope and potential, said George Q. Daley, dean of Harvard Medical School. The work of this years recipients is nothing short of breathtaking in its profoundimpacton medicine. These discoveries have reshaped our understanding of the bodys response to cancer and propelled our ability to treat several forms of this recalcitrant disease.

The Warren Alpert Foundation Prize is given internationally. To date, the foundation has awarded nearly $4 million to 59 scientists. Since the awards inception, eight honorees have also received a Nobel Prize.

Wecommend these five scientists.Allison, Chen, Freeman,Honjoand Sharpe are indisputable standouts in the field ofcancer immunology, said Bevin Kaplan, director of the Warren Alpert Foundation. Collectively,they are helping to turn the tide in the global fight against cancer. We couldn'thonor more worthy recipients for the Warren Alpert Foundation Prize.

The 2017 award: Unraveling the mysterious interplay between cancer and immunity

Understanding how tumor cells sabotage the bodys immune defenses stems from the collective work of many scientists over many years and across multiple institutions.

Each of the five honorees identified key pieces of the puzzle.

The notion that cancer and immunity are closely connected and that a persons immune defenses can be turned against cancer is at least a century old. However, the definitive proof and demonstration of the steps in this process were outlined through findings made by the five 2017 Warren Alpert prize recipients.

Under normal conditions, so-called checkpoint inhibitor molecules rein in the immune system to ensure that it does not attack the bodys own cells, tissues and organs. Building on each others work, the five award recipients demonstrated how this normal self-defense mechanism can be hijacked by tumors as a way to evade immune surveillance and dodge an attack. Subverting this mechanism allows cancer cells to survive and thrive.

A foundational discovery made in the 1980s elucidated the role of a molecule on the surface of T cells, the bodys elite assassins trained to seek, spot and destroy invaders.

A protein called CTLA-4 emerged as a key regulator of T cell behaviorone that signals to T cells the need to retreat from an attack. Experiments in mice lacking CTLA-4 and use of CTLA-4 antibodies demonstrated that absence of CTLA-4 or blocking its activity could lead to T cell activation and tumor destruction.

Subsequent work identified a different protein on the surface of T cellsPD-1as another key regulator of T cell response. Mice lacking this protein developed an autoimmune disease as a result of aberrant T cell activity and over-inflammation.

Later on, scientists identified a molecule, B7-H1, subsequently renamed PD-L1, which binds to PD-1, clicking like a key in a lock. This was followed by the discovery of a second partner for PD-1the molecule PD-L2which also appeared to tame T-cell activity by binding to PD-1.

The identification of these molecules led to a set of studies showing that their presence on human and mouse tumors rendered the tumors resistant to immune eradication.

A series of experiments further elucidated just how tumors exploit the interaction between PD-1 and PD-L1 to survive. Specifically, some tumor cells appeared to express PD-L1, essentially wrapping themselves in it to avoid immune recognition and destruction.

Additional work demonstrated that using antibodies to block this interaction disarmed the tumors, rendering them vulnerable to immune destruction.

Collectively, the five scientists findings laid the foundation for antibody-based therapies that modulate the function of these molecules as a way to unleash the immune system against cancer cells.

Antibody therapy that targets CTLA-4 is currently approved by the FDA for the treatment of melanoma. PD-1/PD-L1 inhibitors have already shown efficacy in a broad range of cancers and have been approved by the FDA for the treatment of melanoma; kidney; lung; head and neck cancer; bladder cancer; some forms of colorectal cancer; Hodgkin lymphoma and Merkel cell carcinoma.

In their own words

"I am humbled to be included among the illustrious scientists who have been honored by the Warren Alpert Foundation for their contributions to the treatment and cure of human disease in its 30+ year history.It is also recognition of the many investigators who have labored for decades to realize the promise of the immune system in treating cancer. -James Allison

The award is a great honor and a wonderful recognition of our work. -LiepingChen

I am thrilled to have made a difference in the lives of cancer patients and to be recognized by fellow scientists for my part in the discovery of the PD-1/PD-L1 and PD-L2 pathway and its role in tumor immune evasion. I am deeply honored to be a recipient of the Alpert Award and to be recognized for my part in the work that has led to effective cancer immunotherapy. The success of immunotherapy has unleashed the energies of a multitude of scientists to further advance this novel strategy. -Gordon Freeman

Iam extremely honored to receive the Warren Alpert Foundation Prize.I am very happy that our discovery of PD-1 in 1992 and subsequent 10-year basic research on PD-1 led to its clinical application as a novel cancer immunotherapy. I hope this development will encourage many scientists working in the basic biomedical field. -TasukuHonjo

I am truly honored to be a recipient of the Alpert Award. It is especially meaningful to be recognized by my colleagues for discoveries that helped define the biology of the CTLA-4 and PD-1 pathways. The clinical translation of our fundamental understanding of these pathways illustrates the value of basic science research, and I hope this inspires other scientists. -Arlene Sharpe

Previous winners

Last years awardwent to five scientists who were instrumental in the discovery and development of the CRISPR bacterial defense mechanism as a tool for gene editing. They wereRodolpheBarrangouof North Carolina State University,Philippe Horvathof DuPont inDang-Saint-Romain, France,JenniferDoudnaof the University of California, Berkeley,EmmanuelleCharpentierof the Max Planck Institute for Infection Biology in Berlin andUmeUniversity in Sweden, andVirginijusSiksnysof the Institute of Biotechnology at Vilnius University in Lithuania.

Other past recipients include:

The Warren Alpert Foundation

Each year theWarren Alpert Foundationreceives between 30 and 50 nominations from scientific leaders worldwide. Prize recipients are selected by the foundations scientific advisory board, which is composed of distinguished biomedical scientists and chaired by the dean of Harvard Medical School.

Warren Alpert (1920-2007), a native of Chelsea, Mass., established the prize in 1987 after reading about the development of a vaccine for hepatitis B. Alpert decided on the spot that he would like to reward such breakthroughs, so he picked up the phone and told the vaccines creator, Kenneth Murray of the University of Edinburgh, that he had won a prize. Alpert then set about creating the foundation.

To award subsequent prizes, Alpert asked DanielTosteson(1925-2009), then dean of Harvard Medical School, to convene a panel of experts to identify scientists from around the world whose research has had a direct impact on the treatment of disease.

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Warren Alpert Foundation Honors Five Pioneers in Cancer Immunology - Harvard Medical School (registration)

‘Shakespeare in the Really Disturbing, Chaotic Park’ – VICE

This story originally appeared in GARAGE Magazine No. 11. GARAGE's life-changing, mind-altering launch is coming soon. Until then, we're publishing some of our old favorites, plus a few original stories, essays, videos, and more to give you a taste of what's to come.

Ian Cheng was born in 1984 in Los Angeles. Now based in New York City, he creates virtual ecosystems he calls "simulations." The simulations are unscripted: they function like video games that play themselves, and Cheng doesn't know exactly how they will turn out. Each is an examination of the dynamics of human behavior, an interrogation of narrative, and an exploration of rationality and motive.

After shows at the Migros Museum in Zrich, the Smithsonian's Hirschhorn in Washington, D.C., Pilar Corrias in London, and an installation in the Whitney Museum's recent exhibition Dreamlands: Immersive Cinema and Art, 1905-2016, Cheng currently has on view his first U.S. museum solo presentation at MoMA PS1, entitled Emissaries, through September 25.

Exclusively for GARAGE, Cheng and Haley Mellin discuss the connection between mind and body, the effects of software on culture, and the tension between deterministic narrative and abysmal base reality.

(This introduction was revised to update the artist's exhibition history.)

Haley Mellin: I just played the digital commission you did for the Serpentine and loved it. What brought you to cognitive science? Ian Cheng: It was a gut feeling. I've always been interested in how human behavior is shaped. What is Mom thinking? What is Dad thinking? What is the cat thinking? What is their misunderstanding? What is my role between them? Things an only child thinks about. Cognitive science seemed to offer a tool set. At the time, at UC Berkeley, that was a combination of neuroscience, linguistics, computer science, and psychology, with an aim of developing a general understanding of cognition that could inform approaches to artificial intelligence.

HM: What was happening with artificial intelligence in the mid-2000s? IC: At the time, artificial intelligence was in the dark ages. Most research was based on a kind of objectivity fallacythe perspective that to make a computer intelligent you had to feed it a million factslike creating a Jeopardy champion. You soon realize that a computer with a million facts quickly exhausts itself. You ask it a question like, "What do you see?" It has no idea. The current paradigm of artificial intelligence is closer to nature. It begins from a position of subjective stupidityyou endow a computer with the ability to sense and develop patterns from its senses. Humans act as its trainer. Like the way a small child or dog learns. Once an AI can learn, regardless of what it learns, it can develop a subjective understanding of the world from the bottom up, rather than from the top down. It can have agency.

HM: What was it that brought you into working with moving digital images? IC: After Berkeley, I worked at Industrial Light & Magic, George Lucas's postproduction visual-effects studio. It was exciting, though, over time, I started to feel like one cog in a very, very big machine. There were hundreds of artisans and technicians working on Optimus Prime punching a skyscraper.

HM: The visual effects in those films are a fascinating force of collaboration. What happened after? IC: I then went to grad school at Columbia's MFA program. My peers were very talented and prolific. But I felt lost. I couldn't bring myself to do anything. I felt art isn't worth doing unless I can find some kind of leverage, some technology that could render the familiar into something alien. When you use a technology that has not been over-exhausted by other people, you have a stake in defining the language, the compositional principles, and a perspective toward that technology. I felt that I needed to do that, in order to feel like I wasn't just polishing territory that many other artists have explored already. I have a constant curiosity for technologies in the loosest sense, whether an actual tool or a soft thing, like a perspective. This leveraging has been an operating principle I have had as an artist since the beginning.

HM: I saw your work first in 2012, at West Street, the apartment gallery that Alex Gartenfeld and Matt Moravec created in New York. The piece was an animation on an iPhone, which I think was placed near a window, with the Hudson River beyond it. The figure in the video was stripped of detailjust essentialswhich came across to me as both primitive and advanced. IC: The video you're talking about is called This Papaya Tastes Perfect. It looks like an animation and it is animated, in fact, but it was done using motion capturea process in which you place markers on a real performer's body, so their movements can be translated onto a digital avatar. Three-dimensional animation has a reputation for being smooth, frictionless, plastic. But I wanted to see if something as artificial as 3D animation could capture human behavior that had the friction, or visceralness, that we find in life itself. This desire to get closer to nature and aliveness led to making what I call "simulations"I think of them as video games that play themselves. They are open-ended software systems that simulate an ecology. It's a form that can contain an ever-evolving relationship between agents and environment.

HM: Your earlier simulations were like chaotic systems. But the recent ones have an element of narrative in them. IC: I found myself thinking about how you and I are creatures of narrative. We eat and breathe narrative. I wanted to use narrativewhich I see as a deterministic, scripted forceto counterbalance the entropy and chaos in the simulations. I begin with open-ended ecosystems, which contain various agents with A.I.s that are very reactive to the environment. Then I introduce one agent who has a very different intelligence a set of narrative goals that it doggedly tries to achieve. It's like giving an actor a script and telling her she has to get through her lines no matter what obstacles get in her way. It's like Shakespeare in the Park, but it's a really disturbing, chaotic park, where everything's going wrong, but the agent still tries.

HM: I like that your content is unpretentious and direct. You're working with sculpting the soft material of human behavior. IC: I feel that having a narrative script, or having a life script, is an incredibly useful tool for orienting oneself, especially in times of uncertainty. It allows you at least to give yourself a direction, and a sense of place within the timeline of the imagined script. It is a self-made fiction, but it gives you courage. In two recent simulations, Emissary in the Squat of Gods and Emissary Forks at Perfection, I've started to program a character that has an orienting script in spite of all the chaos around him or her. What you see as a viewer is a battle between an open-ended ecological system that is amoralthere is no good or bad, things just happen as they do in natureand a highly scripted character who is trying to negotiate this world with a sense of purpose, with a sense of morality. The two forces sculpt each other.

HM: Are the digital materials you're using refined enough to communicate what you're intending, or is there work you want to make that you cannot? IC: I never fully arrive. I keep moving the goalposts. At the moment, I'm trying to figure out a model of intelligence that is located in the relationship between thingsthe idea of intelligence not located entirely in an organism's head, but instead distributed between the organism and the other objects in its environment. Like how the intelligence required to ride a bike is cued by the presence of the bike, but fades away when there is no bike available.

HM: To me, you are a documentarian of what is ahead. Your artwork gives me a feeling of being in a new body. IC: I've realized, in making these simulations, that having a body really matters. More and more, I can't imagine artificial intelligence without some kind of prosthetic body to ground itself in. The A.I. of a self-driving car needs the Umwelt of a car. I've had to find a level of representation that not only we as viewers can relate to, but that the simulated creatures need to achieve agency. That is something I am working on nowhow does the body morphology of a virtual creature influence the intelligence of the creature?

HM: It would be something if you could collaborate with an artificial-intelligence machine and have the artificial intelligence make the body of your character. It would be inventing something that it doesn't know, but inherently must be wired into. IC: I want to make art for children. I want to make work that is engaging to a five-year-old, and to do that, the work has to be alive. Children are the toughest critics.

HM: I played video games, such as Pong, Super Mario Bros., and World of Warcraft as a kid. Did you? IC: Yes. But now I play games to learn from them. In some ways I still feel like a child. Being an artist is like being the most adult-adult and being the most child-child. The reason we're talking now, at 11am, is because I need 7am to 10:59am to be a child. That's when my child brain is on and ideas flow like a tap. It's the opposite of that adult voice of doubt"This is an awful idea. You should be more worried. You haven't answered your email in 10 days." For me, that authority voice is completely absent in the morning, and I can dwell in a childlike state. I talk to myself without embarrassment. By noon, the other side of being an artist kicks in. I have to be more adult than someone with steady employment, because there's no boss. There's no scaffolding, no safety net. Nobody else has the burden of decision-making. It's a total head-trip, because no one tells you in art school that you have to become schizophrenic.

HM: I agree. We've talked about that before. I get emails from you at certain times of the day, not at all hours. I became patient for them. IC: I often want to give the authority to someone else, so they can make the decisions for me in moments of stress. Directors have producers. Start-ups have cofounders. But for artists and writers, no one cares about your work as much as you do. I work with a producer now, which has been a game changer for me.

HM: Sometimes I step back, time goes by, and it allows me to connect in a new way. Hesitation can be a tool. This brings me to think of the team working on the Microsoft HoloLens. It has taken them a long time to develop the technology, they have worked slowly, one foot in front of the other. It will combine digital holograms and reality into a new landscape. It will be like a more advanced state of what we play with Pokmon Go. IC: The best story I heard so far was that this fabulous pink Pokmon was sited inside the Westboro Baptist Church headquarters, and all these kids were rushing in, totally agnostic to the meaning of that place. Just eagerly trying to find the Pokmon inside. It's beautiful. It's a mainstream breakthrough of the idea that the social realities you live in are not strictly rooted in the physical world. A physical place is simply an address to hold multiple social realities, which are often mutually exclusive. It's a refactoring of the familiar by software. Pokmon Go is effectively a work of software in the same way that Uber is a work of software. It fundamentally re-factors the way in which material things are organized, their meaning, status, and value.

HM: Software has changed many of our basic actions. Look at Uber. IC: You couldn't trust getting in a stranger's car five years ago.

HM: Uber shows how an app can reprogram our motion. IC: I don't think a child would go into the Westboro Baptist Church if not for the overriding motivation of getting that amazing Pokmon. It transforms what's meaningful and what's meaningless. We get a clear feeling of the relativity of meaning through this compression of what's valuable and what's sacred versus what's vulgar and what's profane. We see now that software has this collapsing effect.

HM: So what if the battery on your phone dies and there's no amazing Pokmon? IC: You crash like Neo. Or like an Amish person visiting Times Square. You crash back into the shitty base reality that preceded your worldview.

HM: It makes me think of the Philip K. Dick quote you mentioned last year, "Reality is that which, when you stop believing in it, doesn't go away." I love that. It makes things clear and simple. If I stop believing in something, but it remains, then maybe it is real. Is the Pokmon digital character actually there? IC: It's there as much as, if you're a Christian, God is there. It's there in the sense that it organizes your life and is operative in how you act within the world. Whether it's physically real or not is irrelevant. Most of us, except for perhaps enlightened Buddhas, cannot withstand living in direct relationship to raw reality. Raw reality is meaningless and disorienting and almost impossible for any human to accept on a full-time basis. We need games to overlay onto raw reality to orient our lives, whether it's the game of Pokmon or the game of being a Christian or the game of college. Those games crash all the time, creating moments of social unrest and existential angst.

HM: Those are healthy moments, too, and we evolve into yet another game. IC: I've been reading a lot about Buddhism and Hinduism recently. Achieving enlightenment is actually very difficult, because when you're enlightened you're not in a more comfortable place. It's not like you get enlightened and then you're at peace because everything makes sense. Apparently, when you're enlightenedif you can ever be thatyou're actually in a much more abysmal, uncertain, and ambiguous place, but you're simply okay with that. You accept that abyss. This is radical. I think most humans can't withstand this. We're evolved to see faces in clouds. Find meaning. Make up a busy thing to do. There's a reason why monks and enlightened people are secluded in difficult-to-reach low-sensory places, high in the mountains, without too much complex human or ecological drama. It's a zone of minimum viable abyss.

HM: When the underlying structure of how you live and why and what you do breaks apart, finding a new orchestration can be slow, since you are building from the ground up. IC: It's often seen in our culture as a shameful process, like you fell off the wagon.

HM: Or a mental breakdown. IC: When someone falls off the script, there's a lot of shame attached to it, because everyone else in one's local ecology likes to feel secure in the script that's working for them. You can psychologically die in those momentsthat's when you become really depressedbut that's also where there's the most potential for clarity about where you are, and the most potential for reinvention.

HM: Oftentimes, things have to end for a new structure to begin, to start living from a new philosophy. When the system fails you, you create your own system. Often you've invested a lot of energy in a direction that you've taken seriously, and you can see how quickly the structures you relied on unravel. I learned recently how breaking things up is a kind of restructuring. IC: Yes. It forces a restructuring.

HM: There's a difference between what we conserve and what we change. I spend half my time working to preserve wilderness. IC: What parts of the world?

HM: Currently I'm working on an animal-migration corridor joining two national parks in Namibia. I have a different mind space when I'm in stretches of wildernessit's an area that has never had any sort of static structure or use imposed upon it. The body feels that it's not a national park, with all sorts of rules and boundaries. Animals are both very primitive and very advanced. They don't need all the objects and tools we use to live. IC: Yes.

HM: It's healthy for anyone who works in a creative capacity to spend time outside. My brain takes on an ease and rapidity of thought, because there is a lack of social structure. Things become black and whiteanything I am on the fence about becomes clear. IC: We've spoken about transforming things, and I think the things that need to be transformed are modelsculture, ingrained habits, our stories. On the flip side, the things that need to be preserved are the things that have no culture in them. Stretches of wilderness, where nature has built up so much embedded complexity and intelligence, even if it's inherently meaningless to us now. Later, we'll have all that richness and biologic history to learn from.

HM: I want to preserve a space without culture. Those spaces help us to understand what culture is. IC: It's an exercise in being in base reality.

HM: Now we're going in a different direction. IC: That's a good way to end, actually.

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'Shakespeare in the Really Disturbing, Chaotic Park' - VICE

Ethology and veterinary practice: Animal behavior and human perception – MultiBriefs Exclusive (blog)

In previous articles, I've mentioned that we can say nothing about what an animal's behavior means unless we know the context in which is occurs. In the case of companion animals, a key contextual element is the owners' and others' emotional perception of those animals.

However, when it comes to behaviors displayed by companion animals, it's not uncommon for human perceptions of the context to vary even within the same household. The same display from the family dog that one person considers loving, her partner may perceive as obnoxious, while their kids think it's funny. Meanwhile, their visiting relatives hate the dog because "she looks weird."

Those different human responses, in turn, may affect the animal's subsequent behavior in general or only with those specific individuals. Although multiple factors contribute to this mixed perceptual bag within the companion animal household, this month I'd like to consider one factor that practitioners also may experience directly or indirectly.

In a research paper entitled "Tail Docking and Ear Cropping Dogs: Public Awareness and Perception" published in PLOS ONE, Katelyn E. Mills, Jesse Robbins and Marina von Keyserlingk wanted to fill a gap in the literature regarding how surgical alteration of canine body parts affected human perception. Although previous studies explored the perceptions of veterinarians and breeders relative to these surgeries when performed for strictly cosmetic reasons, no one had addressed those of the public.

To provide insight into this segment of the population, the researchers conducted three experiments using American residents as subjects. Data for each experiment included the number of participants, mean age and range, sex and percentage of the total who functioned as the primary canine caregiver in the household.

In the first experiment, researchers showed each participant one professional photo of a dog belonging to one of four breeds in which tail docking and ear cropping commonly occurs: Doberman pinscher, miniature schnauzer, boxer or Brussels griffon. Participants then rated the dog using a list of 10 traits they considered of genetic or environmental origin using seven-point scale.

During the second part of this experiment, the participants received two photographs of the same breed of dog, one with surgically modified ears and tail and one without. The history accompanying these photos stated that the dogs were purebred siblings. Participants then had to choose one of three options to describe what the dogs' different appearances meant:

Although this may come as a surprise to some veterinarians, 42 percent of the 810 participants believed that the short ears and tail were of genetic origin in these breeds.

In the second experiment, the researchers explored if and how the appearance of natural and modified dogs influenced people's perception of the dog's temperament. To determine this, they had a professional artist restore the ears and tails on the photographs of the surgically modified dogs.

When completed, the researchers had two photos of each of the original four dogs: the original photo of the dog with cropped ears and docked tail, and one of the same dog with his or her natural ears and tail restored by the artist. They then asked participants to rate a collection of either all surgically modified or all (artificially restored) natural dog pictures using a canine personality questionnaire.

In general, participants perceived the modified dogs as more human- and canine-aggressive as well as "dominant." Those who received the natural dog photos perceived those animals as more playful and attractive.

Keep in mind that the experiment wasn't designed to determine whether any of these dogs truly possessed those qualities. It was designed to determine if and how cropped ears and docked tails could influence people's perception of dogs so modified.

The third experiment examined how others' perception of the people with these dogs changed depending on the absence of presence of canine ears or tails. In this case, identical full-body pictures of the same man or woman were paired with images of the surgically modified or natural Doberman.

Each participant received images of one man and a modified or natural dog and a second set of a woman paired with either a modified or natural dog. Subjects then had to answer questions regarding their perceptions of the supposed owner as well as the dog.

Given the differences in participants' perception of the modified and natural dogs, again it probably comes as little surprise that the participants' perceptions of the dogs' respective owners also differed. Traits assigned to the presumed owners of modified dogs included more aggressive, more narcissistic, less playful, less talkative and warm than the owners of natural dogs.

Additionally, participants perceived the female owner the of modified dog as more dominant, aggressive and competent than the female owner of the natural dog. Interestingly, the participants perceived the male owner of the modified dog as more narcissistic, less warm and less competent than that same man when paired with the natural version of the same dog.

But if these results will surprise few clinicians, why bother writing about them at all? Like all studies, this one has its flaws.

However, it does further support the notion that some people will make snap judgments of a dog's temperament and the person with the dog based solely on the dog's looks. And because dogs and their people routinely may congregate in veterinary practice waiting rooms, this may directly or indirectly affect how other clients interact with those animals and their people. And that, in turn, may affect the dog's behavior in the examination room as well as the waiting room.

Hopefully and regardless of their personal views, practitioners and their staff members know that cringing in response to every cropped-eared, docked-tailed dog that enters the veterinary clinic won't enhance the dog's behavior. And although it superficially might appear that more positive responses to naturally eared and tailed canines and their owners would be a win-win for everyone, that approach also can backfire.

Just as modified dogs and their owners may dwell anywhere on the spectrum of temperaments and personalities, so may natural dog-owner pairs. And some of these may be nicer and better behaved than others.

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Ethology and veterinary practice: Animal behavior and human perception - MultiBriefs Exclusive (blog)