Soin Neuroscience Files An Orphan Drug Application To Treat Systemic Sclerosis – PR Newswire (press release)

Systemic sclerosis is an orphan disease states effecting less than 250,000 people in the US, and there are not many effective treatments that help the damage to small arteries. "Our modeling suggests that patients suffering from systemic sclerosis will see a marked improvement in blood flow and help reverse or prevent damage to the small arteries that are damaged by the disease," noted Dr. Amol Soin, MD, Founder and CEO of Soin Neuroscience.

Patients suffering from this disease often develop damage to their internal organs due to poor blood flow and develop painful ulcers in the distal portion of their fingers and toes due to the damage to small blood vessels. Dr. Soin noted that at times this pain can become debilitating.

"Another major advantage is that TV1001SR has been shown to be a good painkiller in patients who suffer from damage to small arteries. Given the non-addicting and non-sedating nature of the medication, it can truly help people who are suffering without the side effects of other painkillers."

Dr. Soin went on to say that "The mechanism of action of TV1001SR appears to treat the actual cause of the pain and should also improve the symptoms a patient experiences while at the same time helping to improve the blood flow that was lost due to damage to the small blood vessels. I really think we can help a lot of people."

Typically the FDA responds to Orphan Drug requests within 4 6 months of submission of the application. The Soin Neuroscience team is currently planning for a phase III trial to test TV1001SR for systemic sclerosis which it hopes to begin within the next year.

About Soin Neuroscience:

Soin Neuroscience (SNI) is a pharmaceutical startup company based in Dayton, OH that specializes in treating pain and other neurological conditions. Its lead compound, TV1001SR, is entering late stage trials to treat systemic sclerosis and diabetic peripheral neuropathy. SNI also has multiple other compounds in development including a way to restore functional motor and cognitive function after ischemic stroke, a method to treat intensive care unit myopathy, and is working on an option to treat Huntington's disease. The company was founded by Dr. Amol Soin who is also an inventor on most of the core technologies that are being developed. He can be reached at drsoin@soinneuroscience.com.

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Tinkering connections between architecture and neuroscience – Archinect

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EEG Recording Cap Via Wikimedia Commons

The importance of urban design goes far beyond feel-good aesthetics. A number of studies have shown that growing up in a city doubles the chances of someone developing schizophrenia, and increases the risk for other mental disorders such as depression and chronic anxiety. BBC, Michael Bond

While it might appear as common intuitive knowledge, humans are strongly influenced by their context. In recent years, there has been a significant increase in studies on the connection between neuroscience and architecture.

Last month, London'sConscious Cities Conferencebrought together architects, designers, engineers, neuroscientists and psychologists to encourage more multidisciplinary engagement. Some of the recent psychological studies focus on defining a stimulating space through the use ofwearable devices that monitor skin conductance, various apps, VR and EEG headsets for either visualizing ormeasuring brain's activity and mental states. Other findings include data on the impact of building facades on our moods, green space on our health, and urban environments on our social interactions.

Analyzing the ways in which the built environment affects our brains through evidence-based research can grant architects the insight needed for making healthier and more socially-conscious designs.

AfterShock #3: Brains and the City

Brain Space: One-to-One #37 with Michael Arbib, former vice president of the Academy of Neuroscience for Architecture

AfterShock #4: How I Learned to Stop Worrying and Love Neuroscientific Architecture Research

Archinect's Lexicon: "Neuromorphic Architecture"

Questioning urban truisms with artificial intelligence

A neuroscientist's approach to urban design

Link:
Tinkering connections between architecture and neuroscience - Archinect

Meditation and Neuroscience: New Wave of Breakthroughs in Research on Meditative Practices – Nippon.com

Legs in tights, extending from leotards and terminating in pointe shoes, briskly cut through the air. Instructions are called out as the dancers, faces aglow, carry their arms in delicate arcs and place their feet in deliberate motions. Leading the ballet class at a dance studio in Tokyo is a 27-year-old woman whom we will call Murano Kozue. The students would never imagine that their petite teacher was once quite the juvenile delinquent or that she used to suffer from bulimia stemming from emotional imbalance.

That all began to change when she attended a 10-day meditation retreat in Kyoto on the advice of her mothers friend. Meditation in Japan is generally performed as a Buddhist discipline in pursuit of enlightenment, but this retreat was conducted in a secular setting. The core of the program was silence: Not only were smartphones banned, but participants were also forbidden to talk with one another or even make eye contact. They arose at 4 am and had nothing to eat from noon onward. Until 9 pm each day, they would spend about 10 hours seated on the floor with their legs crossed.

To Murano, this regime felt like torture. Even so, she says, since the training was conducted in the company of other people, it was emotionally easier than being detained one of the solitary rooms at the juvenile classification home. During the 10-day program, she began to take part as a volunteer, doing things like cleaning and cooking for the participants. At first I assumed the people around me were all just acting nice for show, so I was surprised to find that they were genuinely good people. And before she knew it, she had gone for months without binge eating.

It is only in recent years that the effects of meditation, including Zen, on depression and other mental illnesses have been substantiated. Much of the credit goes to molecular biologist Jon Kabat-Zinn of the University of Massachusetts Medical School. A serious practitioner of meditation, Kabat-Zinn developed an eight-week program called Mindfulness-Based Stress Reduction by isolating the techniques of meditation from the context of Buddhism. The program opened its doors in 1979 to patients with chronic pain and stress. As of 2011 more than 19,000 participants had completed the program, proving MBSR effective. The worldwide interest that the program generated has contributed to an exponential increase in studies on meditation in the mainstream of neuroscience research over the past decade.

When mindfulness techniques or Zen meditation heighten ones focus and activate the brain, the functions of the brains dorsolateral prefrontal area are amplified. This strengthens the psyche and boosts the immune system, as well as enhancing ones memory and work efficiency. Those suffering from depression exhibit diminished functions in this area of the brain. Activity in the amygdalathe brains center of emotionincreases instead, making patients more prone to secrete the stress hormone, cortisol. Meditation has been shown to shrink the amygdala.

Fujino Masahiro

In Japan, the heartland of Zen, a rising generation of researchers is endeavoring to unravel the correlation between meditation and the brain, primarily at Kyoto and Waseda Universities.

I visited with Fujino Masahiro, a postdoctoral fellow of the Japan Society for the Promotion of Science, currently enrolled at Kyoto Universitys Graduate School of Education. He is a frontrunner in neuroscience research on meditation.

After finishing college, Id been working at a healthcare company for seven years, Fujino says, when I began to feel that I needed to be healthy myself before I could fully contribute to other peoples health.

It was around that time that he attended a 10-day meditation retreat, where he discovered first-hand how the practice enhanced his well-being. Confronted with a gulf between what he had experienced and public images of meditation, Fujino felt compelled to take action. He resigned from his job and went back to school at Kyoto University, where he applied himself to studying the neuroscience of meditation.

One reason behind the dramatic progress in meditation research is that the idea of neuroplasticitythat the brain retains mutability even in adulthoodhas become widely accepted, explains Fujino. Until the 1990s neuroscientists believed that the brain loses its capacity to change once a person reaches adulthood. But with advances in research on brain function measurement using new techniques like functional magnetic resonance imaging, weve gradually learned that the adult brain, too, continues to be mutable. And in 2004 Richard Davidson, a leading expert in meditation neuroscience, showed that the adult brain can change through meditation as well.

A key concept in discussing plasticity is the default mode network. When we use our senses or engage in activity, different areas of the brain operate together by forming networks. The DMN comes to the fore when we are not doing anything in particular; it is involved in such idle processes as reminiscing about the past and imagining the future. The brain in default mode is like an idling engine. The time spent in this state is what enables us to organize past events and anticipate future ones. But too much DMN time can lead to melancholy and anxiety, as recent studies have shown.

Fujino is collaborating with Ueda Yoshiyuki, a program-specific assistant professor at Kyoto Universitys Kokoro Research Center, using the centers MRI equipment to determine how different types of meditation affect the brain. They have thus far found that Vipassana, or insight meditation, in which the subject observes minute bodily sensations without responding to or judging them, tends to weaken the correlation between the DMN and those areas of the brain associated with emotions and memory.

Individuals struggling with depression or anxiety tend to ruminate excessively on negative experiences and worries about the future. Reducing the link between the DMN and the brains emotional and memory centers makes a person less prone to replaying negative experiences, potentially also freeing the person from anxieties about the future that are projected from those experiences. Fujino is preparing to publish the results of his research in an international journal, hopeful that they may provide clues to achieving a sense of happiness in the present moment.

Changes in the brain induced by an eight-week meditation program, such as MBSR. A. coronal section; B. sagittal section; C. transverse section; D. composite view. Blue indicates the prefrontal cortex, associated with the immune system and resilience. Yellow indicates the hippocampus, associated with memory. The upper red region is the cingulate cortex, associated with emotional and impulse control and dealing with conflict. The lateral red regions are the insulae, which integrate bodily sensations and process internal sensations. The green indicates the amygdala, which governs emotions and regulates stress hormone secretion. Meditation training was shown to increase activity in the blue, yellow, and red regions and reduce activity in the green. Source: R. A. Gotink et al, 8-week mindfulness based stress reduction induces brain changes similar to traditional long-term meditation practicea systematic review. Brain and Cognition, 108 (2016), 3241.

Takahashi Tru

Waseda University, meanwhile, is approaching the default mode network and the effects of meditation from a brain wave angle.

In the 1980s and 1990s, alpha waves were all the rage in electroencephalographic research. Alpha waves, which become dominant when a person is in a relaxed state, were believed to be beneficial for health and to improve work efficiency.

The research by Takahashi Tru of the Waseda University Graduate School of Human Sciences, also a JSPS postdoctoral fellow, runs directly counter to this theory. Takahashis hypothesis is that stronger alpha waves inhibit us from noticing subtle sensations and interfere with insight meditation. Conversely, in a state of mindfulness, alpha waves subside, the senses are heightened, and one becomes keenly aware of ones connection with the surroundings.

In the world of sports, a growing legion of athletes are practicing mindfulness to improve performance. Takahashi is working to develop a neurofeedback system for athletes. The idea is to provide real-time feedback to them on the state of the brain during mindfulness or meditation by measuring biosignals and brain waves, helping them to boost their performance and better practice meditation. Achieving the in the zone state that athletes and racers sometimes speak of may become a simple matter in the relatively near future.

Nomura Michio

Relaxation in the general sense and meditation are different, notes Associate Professor Nomura Michio of the Kyoto University Graduate School of Education, who advises Fujino. Relaxing doesnt relieve brain fatigue; whats important is to ease excessive idling in the DMN state by engaging in meditation. Meditation is a third state of mind distinct from both tension and relaxation.

Thanks to the rapid developments in neuroscience, we have learned that what may seem like relaxationjust sitting around doing nothing and paying attention to nothing in particularis not necessarily good for our mental health. Mindfulness is often seen as being no more than a passing fad. But people may be beginning to realize that there really is something to the third state of mind implied by such words as Zen, meditation, and mindfulness.

(Originally written in Japanese by Koyama Tetsuya and published on April 18, 2017. Photographs by the author unless otherwise stated. Banner photo: PIXTA.)

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secretes mucus, traps microbes, and prevents adhesion. (part o

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Immunology Journals Journals – OMICS International

Immunology is a branch of biomedical sciences that deals with the study of the physiology, molecular biology and genetics of the immune system and its componentsduring the state of wellbeing as well as illness. It studies and implies the physiological, chemical, physical characteristic features of the system towards comprehending the underlying pathophysiology of diseased conditions and developing suitable treatment practices. Immunological research involves study of the structure and function of Thymus, bone marrow, spleen, tonsil, lymph vessels, lymph nodes, adenoids, skin and liver. Classical Immunology is intricately tied with epidemiology and medicine and helps in the study of the relationship between the body system and pathogens, and the role of immune system in safeguarding the body from such attacks.

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A Global Fund To Fight Human Trafficking’s Data – The Daily Caller

This is part two of a five-part series. Read the first part here.

Gary Haugen of International Justice Mission (IJM) cites 45 million slaves worldwide; President Trump cites 27 million slaves; Ivanka cites 20 million slave. They are all in the same room and yet, these are their discrepancies.

Kevin Bales concocted the 27 million number years ago. By 2012, International Labor Organization (ILO) claimed 20.9 million. That number never took into consideration the internet that was reported and exposed as the elephant in the trafficking arena by Homayra Sellier in 1999, and by this journalist in 2000. The 45 million is a number used by an Australia NGO to which Bales has consulted.

Poverty, hunger, mass migrations, war zones,terrorists groups, corrupt states, lack of education and other factors, including earthquakes and tsunamis are fertile grounds for human trafficking. If you analyze how many live on $2 a day, that is almost half the planet.

UNICEF claims 10 million child prostitutes worldwide. UN claims approximately 120 million street children globally; 10 million orphans in Africa due to AIDS, 250 million Dalits in India alone, and somehow the so-called human trafficking experts claim anywhere from 20 45 million slaves. Hardly plausible.

Years ago, David Batstone of Not for Sale, when challenged why he then posted 27 million on his website, apologetically stated that he could not get a seat at the table unless he went along with the US anti-trafficking cabals narrative. That alone makes this coercive data. That is why ethics is needed in this arena.

Innocents at Risk claims, In Washington DC, trafficking innocent children is a $100 million industry. U.S. local NGOs claim their cities are the hubs. Yet, Gary Haugen now claims that human trafficking really flourishes in 12 primary countries. How does that compute if poverty is a factor and 2 billion live on $2 a day, according to Haugen in his TED talk?

In 2014, Jean Baderschneider, another Global Fund architect, gave a speech to the ILO, citing their own outdated numbers.

While none of them seem to agree on the landscape, they do agree that a $1.5 billion fund is needed for data they contradict! US congressional teams say that they too believe that these large U.S. NGOs are only interested in money. It only seems logicalto ask Who has the gall to ask for $1.5 billion when they contradict each other, but who would possibly think this was a sane idea to award $1.5 billion to anyone whose data is wrong?

Or, are there other reasons behind their motives? Are these large US NGOs tired of raising monies, and now, they want a hedge fund like monopoly for their financial sustainability to hijack human trafficking for political agendas? Is not that the very globalization issue that candidate Trump campaigned against? With no blame to the Trumps here at all, these large US NGOs are tenacious and clever as they have built their cottage industry cabal for the last 17 years, but they have proven their model of self-sustainability financially is not doing the job. Bigger is not better with this particular social issue. If anything, it should be run like a business fighting a business of crime.

The 2012 ILO numbers do not incorporate the massive upside down world we live in which contributes to the increase in human trafficking the implosive effect by the internet, Arab Rising ramifications, increase in mass migrations unknown since World War II from West Africa across Northern Africa and the Middle East, from the Arabian Peninsula into Central Asia, onto Europe and even landing in the Australian-paid detention centers in Nauru and Papa New Guinea. ILO does not take into consideration the parades of unaccompanied children headed north from Guatemala into Mexico and transported and trafficked along the way on the beast trains to the U.S. southern border. ILO does not count ISIS and the blood, organ, sex, and labor spikes even in Libya, or the Yemen torture chambers, the tens of thousands of children gone missing in Europe, the Boko Haram girls, and the spike in public auctions.

The data today does not take into consideration the massive underbelly of transnational and trans-criminal human trafficking enterprises that engulf terrorism on a scale not witnessed in human history, while transported over the internet by images, and buried in the Dark Net internet recesses of Tor and Bitcoin. The data does not take into consideration the opiate issue in the US and Australia where homeless children engage in survival-sex to get their next fix. Recently, in Maryland, a 15 year old girl, hooked on heroin, was sold by her own mother in state and across state lines.

None of these figures fully grasps the nearly 2 million homeless children in America where homeless shelters for youth close at 5 or 6pm and they have no place to go unless they negotiate a trick for a bed, nor those 65 million migrants worldwide. Nor does it address children at risk who are institutionalized, disabled, in foster care, or recycled through jails, who were repeatedly raped starting at four or five years of age when the suffering began that Philadelphia psychiatrist, Dr. Jean Langberg, calls compounded trauma that spirals their lives out of control.

This U.S. NGO cabal leading this Global Slush Fund has no shame because they know their narratives and facts are inconclusive. We needbrazen ethics, critical thinking and analysis to grasp the breath and width of this global phenomenon, not promises of funds. No one is addressing the child rape that leads to livesspentin spiritual, physical, and emotional in pain, mental illness, broken relationships, and cycles of humantrafficking, except the older survivors whose lives have been impacted for years. In the background, is the ever present Internet thatnormalizes what in decades past was not accepted normal human behavior, yet the hypocrisy is played out with these large U.S. NGOs because they fall short of fully demanding a zero tolerance of Silicon Valley because they accept their donations.

ILO numbers should be questioned fully. The ILO is a UN agency. The UN still does not fully address their own human trafficking issues. They still have employees and contractors engaged in food for sex trafficking models. While the UN Global Impact wants corporations to take the deep dive on their internal supply chains, the United Nations to date has never cleaned up their own internal contribution to human trafficking. Nor, have these NGOs ever cleaned up their contribution to this disinformation campaign. Instead, they lead with what sells. Instead of reality.

Homayra Sellier, Founder and CEO of Innocence in Danger in Europe challenges the hypocrisy of these US NGOs,

The UN must go beyond their declarations of child protection claiming they stand for fighting all forms of abuse and trafficking. It is a fact that UN soldiers abuse children in countries and war zones where they are commissioned to protect marginalized communities. If the UN ceases to stand up for the very values it was created for, then the UNs utility is in question. All member states should stop financing an organization whose priorities are no longer to keep populations safe. The UN must be held accountable for fueling the very child abuse that they publicly denounce. Institutionally, they are no different than any other institution. We are not what we say. We are what we do!

Rivers Teske, Founder and CEO of Hidden Choices of Westport, Connecticut also challenges them, It is time to acknowledge that big is not better, that small NGOs on the ground do the work, and that these larger U.S. NGOs want to take credit for their work. We need results. We need ethics front and center. Too many children and families are being profoundly harmed. The internet must be challenged for the sake of humanity.

Christine Dolan is an investigative journalist, and the former CNN Political Director. She is an authority on human trafficking globally having covered it for over 17 years. She is the author of Shattered Innocence The Millennium Holocaust, and In the Name of God, two authoritative investigations on the global phenomenon of human trafficking.

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A Global Fund To Fight Human Trafficking's Data - The Daily Caller

Brooks: Selfishness makes enemies and destroys empires – The Durango Herald

This week, two of Donald Trumps top advisers, H.R. McMaster and Gary Cohn, wrote the following passage in The Wall Street Journal: The president embarked on his first foreign trip with a cleareyed outlook that the world is not a global community but an arena where nations, nongovernmental actors and businesses engage and compete for advantage.

That sentence is the epitome of the Trump project. It asserts that selfishness is the sole driver of human affairs. It grows out of a worldview that life is a competitive struggle for gain. It implies that cooperative communities are hypocritical covers for the selfish jockeying underneath.

The essay explains why the Trump people are suspicious of any cooperative global arrangement, like NATO and the various trade agreements. It helps explain why Trump pulled out of the Paris global-warming accord. This essay explains why Trump gravitates toward leaders like Vladimir Putin, the Saudi princes and various global strongmen: They share his core worldview that life is nakedly a selfish struggle for money and dominance.

It explains why people in the Trump White House are so savage to one another. Far from being a band of brothers, their world is a vicious arena where staffers compete for advantage.

In the essay, McMaster and Cohn make explicit the great act of moral decoupling woven through this presidency. In this worldview, morality has nothing to do with anything. Altruism, trust, cooperation and virtue are unaffordable luxuries in the struggle of all against all. Everything is about self-interest.

Weve seen this philosophy before, of course. Powerful, selfish people have always adopted this dirty-minded realism to justify their own selfishness. The problem is that this philosophy is based on an error about human beings and it leads to self-destructive behavior in all cases.

The error is that it misunderstands what drives human action. Of course people are driven by selfish motivations for individual status, wealth and power.

But they are also motivated by another set of drives for solidarity, love and moral fulfillment that are equally and sometimes more powerful.

People are wired to cooperate. Far from being a flimsy thing, the desire for cooperation is the primary human evolutionary advantage we have over the other animals.

People have a moral sense. They have a set of universal intuitions that help establish harmony between peoples. From their first moments, children are wired to feel each others pain. You dont have to teach a child about what fairness is; they already know.

People have moral emotions. They feel rage at injustice, disgust toward greed, reverence for excellence, awe before the sacred and elevation in the face of goodness.

People are attracted by goodness and repelled by selfishness. Good leaders like Lincoln, Churchill, Roosevelt and Reagan understand the selfish elements that drive human behavior, but they have another foot in the realm of the moral motivations. They seek to inspire faithfulness by showing good character. They try to motivate action by pointing toward great ideals.

Realist leaders like Trump, McMaster and Cohn seek to dismiss this whole moral realm. By behaving with naked selfishness toward others, they poison the common realm and they force others to behave with naked selfishness toward them.

By treating the world simply as an arena for competitive advantage, Trump, McMaster and Cohn sever relationships, destroy reciprocity, erode trust and eviscerate the sense of sympathy, friendship and loyalty that all nations need when times get tough.

By looking at nothing but immediate material interest, Trump, McMaster and Cohn turn America into a nation that affronts everybody elses moral emotions. They make our country seem disgusting in the eyes of the world.

George Marshall was no idealistic patsy. He understood that America extends its power when it offers a cooperative hand and volunteers for common service toward a great ideal. Realists reverse that formula. They assume strife and so arouse a volley of strife against themselves.

I wish H.R. McMaster was a better student of Thucydides. Hed know that the Athenians adopted the same amoral tone he embraces: The strong do what they can and the weak suffer what they must.

The Athenians ended up making endless enemies and destroying their own empire.

David Brooks is a columnist for The New York Times. Reach him c/o The New York Times, Editorial Department, 620 8th Ave., New York, NY 10018. 2017 New York Times News Service

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Mouse lemur could serve as ideal model for primate biology and human disease – Phys.Org

June 7, 2017

The mouse lemurthe world's smallest primatehas the potential to transform the field of genetics and serve as an ideal model for a wide range of primate biology, behavior and medicine, including cardiovascular disease and Alzheimer's disease, Stanford University School of Medicine researchers say.

For decades, scientists have relied on mice, fruit flies and worms as genetic models, but despite all their success, these organisms routinely fail to mimic many aspects of primate biology, including many human diseases, said Mark Krasnow, MD, PhD, professor of biochemistry.

Frustrated by the lack of a good study model, Krasnow and his colleagues turned to the mouse lemur and began conducting detailed physiologic and genetic studies on hundreds of these petite, docile creatures in the rainforests of Madagascar.

Working in a Stanford-funded lab on the island country, the scientists report that they already have identified more than 20 individual lemurs with unique genetic traits, including obesity, high cholesterol, high blood sugar, cardiac arrhythmias, progressive eye disease and motor and personality disorders. Their hope is that continued study of these abundant primates could lead to a better understanding, and possibly better treatments, of these and other conditions in lemurs and humans.

'Huge potential'

"I think mouse lemurs have great potential for our understanding of primate biology, behavior and conservation, in the same way that fruit flies and mice over the last 30 or 40 years have transformed our understanding of developmental biology and many other areas of biology and medicine," Krasnow said. "Some of the most fascinating and important questions that need to be answered are primate-specific. For those, we really need something besides humans to complement the work that has been done in fruit flies and mice."

A paper describing the researchers' findings will be published online June 9 in Genetics. Krasnow is the senior author. Lead authorship is shared by graduate student Camille Ezran and postdoctoral scholar Caitlin Karanewsky.

The project began in 2009 when Krasnow, frustrated by the lack of a good animal model for lung diseasehis area of expertisecommissioned three high school interns to search the animal world for something better. By the end of the summer, the interns had come up with the mouse lemur, which fits all the necessary criteria: Like mice, these animals are small (about twice the size of a mouse), develop quickly, reproduce rapidly, produce many offspring, and are inexpensive and easy to maintain and manage. In genetic terms, the mouse lemur is about midway between humans and mice, Krasnow said.

"When I talk to scientists, their faces light up when I tell them about mouse lemurs because they are about the size of a mouse but they are primates, so that makes a huge difference," said Ezran, who was one of the high school interns. "I think they really do present such great potential for biological, behavioral and medical research in general."

Early on in the project, Krasnow sought out the perspective of Stanford veterinarians, ultimately recruiting Megan Albertelli, DVM, PhD, assistant professor of comparative medicine. A geneticist and primate specialist, Albertelli said she was initially skeptical of the idea of lemurs as animal models, but soon became enthusiastic after realizing their enormous potential for contributions in understanding neurologic problems, eye disease and other conditions where mouse models have fallen short.

Trip to France

She accompanied the group on a trip to France to visit with scientists who had been studying lemurs in the laboratory for years. A French team had found that some aging lemurs develop a form of dementia and accumulate plaques in the brain that resemble those of Alzheimer's patients.

"I saw that they were promising models for Alzheimer's disease," Albertelli said. "Alzheimer's is a condition that is hard to model in other animal species, so that was very exciting."

Mouse lemurs live exclusively on Madagascar, where they are found in great abundance. Tens of millions of them populate the island. While lemurs generally are endangered due to habitat destruction, mouse lemurs are not under threat and freely roam the island, said Ezran, who calls them the "rodents of Madagascar."

The Stanford researchers began to develop collaborations with other scientists studying lemurs, including those at the Centre ValBio near the Ranomafana National Park in Madagascar, who have been examining lemur ecology, family structure and behavior for decades.

During periodic visits to the island, Krasnow and his colleagues learned how to catch brown mouse lemurs in the rainforest just outside the research station, using a tiny banana slice inside a trap as a lure. The scientists then tagged and photographed each animal, gave them a thorough physical examination, analyzed them for behavioral issues and abnormalities and removed a drop of blood for detailed genetic and serum studies. The animals then were released back into the wild so the researchers could follow them over time to see how their environments may influence their progress and health. In 2013, Stanford built a sophisticated molecular biology and genetics lab within the ValBio complex, where these studies could be carried out.

'Distinctive personalities'

Lemurs have distinctive personalities, Krasnow said, and the researchers gave each one a name, based on his or her looks or behavior. For instance, one was named Feisty for his unusually aggressive nature; most lemurs are docile.

The work has led to a whole new way of doing genetic studies, said Krasnow, who is also a Howard Hughes Medical Institute investigator. Instead of using the traditional method of introducing genetic mutations into mice to create "knockout" miceor animals with customized genesthey found they were able to find naturally occurring variants among animals in the wild. Moreover, in working with lemurs in their native habitats, the researchers could better understand how the animals interact with their surroundings and the relationship between genes and the environment.

"Instead of introducing mutations in mice or fruit flies, we are doing something much more similar to what is done in humans," he said. "We are looking at all the wonderful genetic variation already existing in nature, since there are so many millions of mouse lemurs out there. We calculate that most 'knockout' mutations are already present in nature, and all we have to do is find them. And because the cost of sequencing a genome is rapidly dropping, it's now possible to sequence the genomes of thousands of mouse lemurs to see what mutations they are carrying."

In doing so, the researchers could accomplish in a few years for a tiny fraction of the cost what the International Knockout Mouse Consortium will accomplish in 10 years, at a cost of nearly $1 billion, he said.

But the project could use some additional staff, as the process of capturing the animals and screening them in the laboratory is labor-intensive, he said. He and his colleagues have come up with a multipurpose solution that will contribute to the local educational system while helping preserve the lemur populations in Madagascar, whose habitats are threatened by farming, mining and logging interests, he said.

Help from students

The group is developing a science curriculum for use in Malagasy high schools in which students learn about biology by exploring the rich environment right outside their school houses. Among the instructors is Manu Prakash, PhD, assistant professor of bioengineering at Stanford and a pioneer in the field of "frugal science," who has brought his powerful $1 paper microscopes to Madagascar and taught students how to explore the microscopic world in which they live, including the lice in their hair, the pathogens in their water and the disease-causing parasites in their environment. The curriculum was first introduced among university students, some of whom now are screening lemurs at the Stanford lab in Madagascar.

"We saw this as an opportunity because we are going over there to study the unique animals and biology and ecology of Madagascar, which is unsurpassed in the world," Krasnow said. "It is the No. 1 hotspot for biodiversity, but most of the students don't realize what they have in their backyards because they are being taught from textbooks and from teachers who have learned from Europeans."

He said the researchers hope to expand scientific curricula at all levels of education, helping train the Malagasy scientists of the future and build scientific capacity in the country, all the while creating an appreciation among the local population of the need to understand and preserve lemurs and other species for the future.

"We are trying to do this in a way that is respectful and will help the lemurs and the people of Madagascar, while enlightening many aspects of primate biology and human disease," he said.

The researchers plan to make the genetic sequencing and phenotyping information they obtain from the lemurs publicly available so that researchers around the world can take advantage of this trove of knowledge, Albertelli said.

Explore further: Three new primate species discovered in Madagascar

Scientists from the German Primate Center (DPZ), the University of Kentucky, the American Duke Lemur Center and the Universit d'Antananarivo in Madagascar have described three new species of mouse lemurs. They live in the ...

The ring-tailed lemur, an iconic primate that is emblematic of the wild and wonderful creatures inhabiting the tropical island of Madagascar, is in big trouble.

Scientists have identified two new species of mouse lemur, the saucer-eyed, teacup-sized primates native to the African island of Madagascar.

A Malagasy-German research team has discovered a new primate species in the Sahafina Forest in eastern Madagascar, a forest that has not been studied before.

Facial recognition is a biometricsystem that identifies or verifies a person from a digital image. It's used to find criminals, identify passport and driver's license fraud, and catch shoplifters. But can it be used to ...

Today, Madagascar is home to a mosaic of different habitatsa lush rainforest in the east and a dry deciduous forest in the west, separated by largely open highlands. But the island off the southeast coast of Africa hasn't ...

In 1859, Charles Darwin included a novel tree of life in his trailblazing book on the theory of evolution, On the Origin of Species. Now, scientists from Rutgers University-New Brunswick and their international collaborators ...

You've been there: Trying to carry on a conversation in a room so noisy that the background chatter threatens to drown out the words you hear. Yet somehow your auditory system is able to home in on the message being conveyed ...

Worms, it appears, are good at keeping secrets.

When a soil dries out, this has a negative impact on the activity of soil bacteria. Using an innovative combination of state-of-the-art analysis and imaging techniques, researchers at UFZ have now discovered that fungi increase ...

It's usually pretty easy for dedicated scientists with years of experience to tell two species of their favorite organism apart, be it squirrels or birds. The scientists have seen a lot of the animal they specialize in, and ...

Noise from motorboats is making fish become bad parents, and reducing the chance of their young surviving, research led by marine experts at the University of Exeter has shown.

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Mouse lemur could serve as ideal model for primate biology and human disease - Phys.Org

Genetics authority to continue as director of US health institute – Reuters

Genetics pioneer Francis Collins will continue as director of the U.S. National Institutes of Health (NIH), the White House said in a statement on Tuesday.

President Donald Trump has proposed a 20 percent cut amounting to $5.8 billion to the NIH budget, a move which has been called a "catastrophe" by some heart doctors and researchers in the country.

Collins, a medical doctor with advanced degrees in chemistry, was nominated to head the NIH by former U.S. President Barack Obama in 2009. He said he was grateful for Trump's trust in his ability to continue to lead the NIH.

The NIH is one of the world's foremost medical research centers and has had a key role in important discoveries including the invention of magnetic resonance imaging, the mapping of the human genome and, more recently, the development of CRISPR, a genome editing tool that is fueling a boom in new treatments and products from medical and pharmaceutical companies.

(Reporting by Kanishka Singh in Bengaluru; Editing by Bill Trott)

NORRISTOWN, Pa. Bill Cosby's lawyers on Wednesday tried to undermine the account of the woman who accused him of sexually assaulting her in 2004, questioning apparent inconsistencies in her statements to police and suggesting she was after money.

The United States has joined a lawsuit accusing the city of Los Angeles of failing to develop affordable housing for disabled people despite accepting millions of dollars of federal funds for that purpose, the Department of Justice said on Wednesday.

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Genetics authority to continue as director of US health institute - Reuters

BRIEF-Takeda, Seattle Genetics announce Lancet publication – Reuters

CORRECTED-Investors expect to meet with Exxon on climate-impact report

HOUSTON, June 1 Exxon Mobil Corp investors will push to meet with oil company officials this summer to hash out elements of a climate-impact analysis following a shareholder vote calling for studies of technology and climate-related risks to its business.

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BRIEF-Takeda, Seattle Genetics announce Lancet publication - Reuters