BRIEF-Newlink Genetics says Roche Group member Genentech informed co that it intends to return rights to IDO … – Reuters

June 8 Newlink Genetics Corp

* Newlink Genetics - on June 6, Genentech, a member of Roche Group, informed co that it intends to return rights to IDO inhibitor GDC-0919

* Newlink Genetics - rights co had licensed to genentech with respect to GDC-0919 will revert to co when termination becomes effective

* Newlink Genetics - research collaboration with Genentech for discovery of next generation IDO/TDO (tryptophan 2,3-dioxygenase) inhibitors continues Source text for Eikon: Further company coverage:

* Bain, Western Digital in group led by Japan state fund -sources

June 8 BlackRock Inc said on Thursday it hired Goldman Sachs' Heather Brownlie as its U.S. head of fixed-income ETFs.

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BRIEF-Newlink Genetics says Roche Group member Genentech informed co that it intends to return rights to IDO ... - Reuters

The monk who became the ‘father of genetics’ – Catholic Star Herald

This is the first piece in a series exploring Catholicism and science.

We know well the churchs stance that reason (ratio) can never be ultimately alien or antithetical to fides (faith), for God is the Source of all Truth. A disproportionate overtaxing of the aims and abilities of human nature as the basis for all social, ethical and political realities can and has led to totalitarian systems which have been disastrous for humanity (Fides et Ratio, 46). Yet the answer to these challenges is never a flight into the feeling and experience of unmitigated fideism, with no relationship to rational reflection, for this ends in religious expression withering into myth or superstition (FeR, 48).

This series will hope to emphasize the relationship between scientific thought and religious conviction, always recognizing the distinct spheres of both because using Scripture as a proof text for a scientific claim, or enshrining a scientific hypothesis as an indubitably revealed truth, is neither good science nor good theology. Yet faith and reason are famously recognized as the two wings on which the human spirit rises to the contemplation of the Truth.

These anthropological and theological claims do not preclude us from examining the contributions people of faith have made to the progress of human knowledge in various scientific disciplines. On the contrary, they impel us to do so. And with the proliferation of television commercials for private companies offering to help us explore our genetic past and the impact it has on our children and grandchildren, there is no better place to begin than with Gregor Mendel.

Mendel was born in 1822 in what is today the Czech Republic. An Augustinian monk, he studied math and botany in Vienna. When he returned to the monastery, he experimented with pea plants and came to realize that traits were passed on in independent pairings of what he coined dominant and recessive factors (now called genes), not inherited in equal proportions from each of the preceding generations as previously thought. He is thus known as the father of genetics.

Both the ability to identify genetically inherited diseases and to engineer plant varieties for more desirable qualities (e.g., corn with optimal kernel size, shape, color, durability, and resistance to pests) are indebted to the work of Mendel.

It is well known that prayer and praise formed and supported Mendels exploratory search for truths about life on our planet. He recognized the importance of creatureliness and what this implied: both limitation to our self-determination and a relationship with the Creator and the natural world in which we live.

Like Anselm of Canterbury almost a millennium before him, Mendel saw in his rigorous investigations a path toward union with the divine. As Mendels predecessor put it: Come now, insignificant man, fly for a moment from your affairs, escape for a little while from the tumult of your thoughts. Enter into the inner chamber of your soul, shut out everything save God and what can be of help in your quest for him Come then, Lord my God, teach my heart where and how to seek You, where and how to find You. Teach me to seek you, and reveal yourself to me as I seek, because I can neither seek you if you do not teach me how, nor find you unless you reveal yourself. Let me seek you in desiring you; let me desire you in seeking you; let me find you in loving you; let me love you in finding you.

Mendel died at 61 years of age after serving as a friar, botanist, abbot, and author. It was not until decades after his quiet death in the monastery that his genius was recognized by the international academic community, and his important role in this history of human self-understanding confirmed.

Collingswood native Michael M. Canaris, Ph.D., teaches at Loyola University, Chicago.

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The monk who became the 'father of genetics' - Catholic Star Herald

Embryology – TeachMeAnatomy

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‘I could not have written a better scenario for my life’: Father Charlie Cheverie marks 60 years as a priest – CBC.ca

On Sunday June 18 there will be a celebration at St. Eugene's Parish Church in Covehead, P.E.I.,for Father Charlie Cheverie who is marking 60 years as a priest. He spent time teaching biology atSt. Dunstan'sUniversity and UPEIand had the opportunity to minister at St. Eugene's.Cheverie stopped by CBC News:Compass to talk about his time in the Catholic Ministry.

For the last couple years before I finished off St. Dunstan'sUniversity, I had a real good girlfriend at that time and I prayed for many years for my vocation, what God was asking me to do. I thought she was the one that God wanted me to have for my wife. When I went to seminary for the first year, I prayed, 'Lord, what do you want me to do?' And near the end of that year, my spiritdirector asked me, realizing that I wanted to go forward to go on to medicine,'do you want to heal the body, or heal the person?' and I said 'I want to heal the person.' I don't know how long it tookme to do that, to say that, and get to that degree, but there it was. Take your orders. And since that time I have not turned back. And so that was the beginning, that was the path I chose.

No, I thanked the Lord. I could not have written a better scenario for my life. It's beautiful.

When I think of the priesthood, I think of a parish priest and what you'd normally see a priest doing. But when I was ordained, they decided that I was to go on to study biology, which I did,got my masters and PhD and then I'd come back to teach biology. It took me a couple of years to appreciate that there was a ministry there with the young people which I spent the rest of my life doing really. And it was kind of ironictoo because having thought about medicine, I end up teaching those subjects which mostly those who were going for medicine would take. Anatomy, embryology, histology and so forth. Right now I have a lot of people on P.E.I. who are taking care of me who are my former students. Butteaching biology isn't what I thought of. In fact I think if I go back to that first year in seminary, if somebody asked me 'do you want to teach biology for the rest of your life?' I would have said 'no, I'm going out for medicine' and that would have been it.And then in 1975 another big blessing came into my life when I was called to minister at St. Eugene's in Covehead, P.E.I. It didn'ttake long for me to realize that there are a lot of fabulous people in Covehead and surrounding areas. I met a lot of people, Catholic and non-Catholic, that became my friends and still fabulous friends and very, very important people in my support system.

It's a matter of journeying with people, whether it be students, adult people, whatever the case may be. Personally I find it difficult to journey with people who are having real difficulty, real crosses in their lives. Maybe people struggling with cancer, or maybe people who arestruggling with Alzheimer's disease or dementia, or people who are just having some failure in their particular life. To try to be there to console them, to be with them, support them as best I possibly can. And that's when I really depend on the Lord to give me that extra help.

It's just the joy I've had in my communication with all my friends all the way through my life. Go back to Queens Square School where we played hockey, rugby and sports together, and then later on in our youth club, the friends I met there and the joy I had from there. Then in university and the parishes, it's just the joy that you have from dealing with people. And to realize that the more you give, the more you get. I used to tell this to students at the university, I said 'if you want to get a smile, give a smile' and sure enough, it'samazing. I had a friend of mine, we went over to St. Mary's one time and we were walking along the campus and I was saying 'hi' and 'hi' and smiling at people. And he said 'do you know all those people?' and I said 'no, I don't know any of them.' It's not necessary to know them all, but you'll get to know them if you go that way yourself.

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'I could not have written a better scenario for my life': Father Charlie Cheverie marks 60 years as a priest - CBC.ca

12-hour biological clock coordinates essential bodily functions – Baylor College of Medicine News (press release)

Some bodily activities, sleeping, for instance, mostly occur once every 24 hours; they follow a circadian rhythm. Other bodily functions, such as body temperature, cognitive performance and blood pressure, present an additional 12-hour cycle, but little is known about the biological basis of their rhythm. A team of scientists from various institutions, including Baylor College of Medicine, has revealed that, in addition to 24-hour clocks, mammals and other organisms have 12-hour clocks that are autonomous, work independently from 24-hour clocks and can be modified by external factors. Studying 12-hour clocks is important because altered 12-hour cycles have been linked to human disease. The study appears in Cell Metabolism.

Our lab has been working on how the 24-hour cycles are regulated, and we and others have shown that disturbing these clocks may lead to diseases of metabolism, said senior author Dr. Bert OMalley, chair and professor of molecular and cellular biology and Thomas C. Thompson Chair in Cell Biology at Baylor College of Medicine. For instance, experimental evidence shows that night-shift workers who periodically change their night and day shifts or people who travel overseas often alter their sleep cycles, and this seems to make them prone to gain weight and develop diabetes and other alterations of metabolism that may lead to disease. Its not a good idea to disturb the circadian rhythm on a regular basis.

In addition to physiological activities that cycle every 24 hours, mammals and other organisms have activities that repeat every 12 hours. For example, it has been reported that blood pressure, body temperature, hormone levels and response to therapy fluctuate in 12-hour cycles. In addition, altered 12-hour cycles have been associated with human diseases. Other researchers had identified about 200 genes that are activated in 12-hour cycles. In this study, OMalley and his colleagues set out to determine whether there was a larger number of 12-hour genes and whether their cycles followed the definition of a biological clock, that is whether they worked autonomously and their oscillation could be adjusted by the environment.

Math meets biology to indentify the bodys internal clocks

Dr. Bokai Zhu, first author of this study and a postdoctoral fellow in the OMalley lab, carried out biological analyses to determine the activity of thousands of mice genes in time. Then, co-author Dr. Clifford Dacso, professor of molecular and cellular biology at Baylor College of Medicine, and co-author and mathematician Dr. Athanasios Antoulas, professor of electrical and computer engineering at Rice University, applied mathematical analyses to these biological data.

We were surprised to identify more than 3,000 genes that were expressed following 12-hour rhythms. A large portion of these genes was superimposed on the already known 24-hour gene activities, Zhu said.

The 12-hour clock is autonomous and can be synchronized by external cues

Further work showed that the 12-hour rhythms of genetic activity work as biological clocks. They occur regularly and autonomously in the cells, and their oscillation can be synchronized by certain external stimuli. OMalley and colleagues discovered that 12-hour clocks are independent from 24-hour clocks. When they experimentally eliminated a 24-hour clock, 12-hour clocks continued ticking. Furthermore, the external cues that can synchronize 24-hour clocks, such as sunlight, do not affect 12-hour clocks.

Of all the genes we analyzed, two sets with 12-hour cycles stood out; those involved with protein quality control and processing, which mainly occur in a cellular structure called endoplasmic reticulum, and those related to the energy supply of the cell, which involves the mitochondria, Zhu said. The activities of the endoplasmic reticulum and mitochondria depend on each other, and we have shown here that the 12-hour genes in the endoplasmic reticulum are synchronized with the 12-hour genes in the mitochondria, which provide the energy needed for protein processing.

In addition, we found that certain liver conditions are associated with disturbed 12-hour gene expression in mice. We anticipate that further study of 12-hour cycles might lead to opportunities to improve prevention of or treatments for diseases of the liver and other organs in the future, OMalley said.

Other contributors to this work include Qiang Zhang, Yinghong Pan, Emily M. Mace and Brian York. The authors are affiliated with one or more of the following institutions: Baylor College of Medicine, Rice University, the University of Houston and the Max Planck Institute.

This research was supported by grants from the NationaI Institutes of Health (U24 DK097748 and R01 HD07857), the Brockman Foundation, the Center for Advancement of Science in Space, Peter J. Fluor Family Fund, Philip J. Carroll, Jr. Professorship, Joyce Family Foundation, the National Science Foundation Grant CCF-1320866 and the German Science Foundation Grant AN-693/1-1.

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12-hour biological clock coordinates essential bodily functions - Baylor College of Medicine News (press release)

BRIEF-Beijing Leadman Biochemistry says dividend payment date – Reuters

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BRIEF-Beijing Leadman Biochemistry says dividend payment date - Reuters

Anatomy of an apology – The Trimble Banner

By the time you read this, this will be old news and the nation will most likely have already moved on to the next outrageous thing. However, as Im writing this, Kathy Griffin is making headlines. Who is Kathy Griffin (and why should you care)? Shes a 56-year-old comedian and self-identified D-list celebrity known for being abrasive, brash, crude and sarcastic. Most recently she made the national news when she posed for a photo, holding up the fake, but realistic, bloody decapitated head of President Donald Trump. Immediately, she experienced widespread backlash, and even lost a number of jobs, including a longstanding gig on CNN as their New Years Eve in Times Square co-host. Within hours, and with two lawyers at her side, she gave a tearful press conference apologizing for her artistic statement, as she called it. Although no one but God really knows a persons heart, its not a stretch to say her apology may not have been heartfelt. She quickly went from, I went too far...I sincerely apologize, to, It is Trump who should apologize...for being the most woman-hating and tyrannical president in history, among other accusations. In other words: Im sorry, but.... Whenever someone says, Im sorry, but... you can bet that theyre not sorry. They may be sorry they got caught and sorry their actions caused them to suffer consequences, but the but is the real message. Im sorry, but you deserved it. Im sorry, but you made me do it. Im sorry, but youve done worse. Im sorry, but Id do it again. Im sorry, but youll be even more sorry when Im done with you. Chan-ces are youve heard that from someone -- or thought it about or said it to someone else. Im sorry, but.... In the book, The Five Languages of Apology, authors Gary Chapman and Jennifer Thomas describe five languages or ways people deliver and/or accept apologies: expressing regret (Im sorry), accepting responsibility (I was wrong), making restitution (What can I do to make it right?), genuinely repenting (Ill try not to do that again) and asking for forgiveness. Chapman and Thomas write that not every person who has been wronged needs to hear all five from the person who has hurt them, but that can be true. It depends on the nature of the wrong, the damage it has caused and the individual emotional needs to the wronged person. As an aside, the book includes a quiz to determine your language. Mine came out equally as expressing regret and accepting responsibility. So, if you wrong me in the future, I need you to own what you did and express true regret. A gift card to Ulta or Panera is also acceptable. The authors said the one universal aspect of an apology is that it cant contain a but. A person needs to take full responsibility, blame only him- or herself. In a perfect world, there would be no need for apologies, Chapman and Thomas write. But because the world is imperfect, we cannot survive without them...Something within us cries out for reconciliation when wrongdoing has fractured a relationship. The desire for reconciliation is often more potent than the desire for justice, and the more intimate the relationship, the deeper the desire for reconciliation. They go on to write, The need for apologies permeates all human relationships, and that without apologies, anger builds.... In the 1970 movie Love Story, after Oliver tells Jenny, Im sorry, Jenny replies, Love means never having to say youre sorry. However, thats not only impossible for flawed humans, but its also not true. In fact, the opposite is true: Real love is humble enough to admit ones wrongs. Real love apologizes -- without a but -- and real love offers forgiveness in return. Jesus told his followers: If you are about to place your gift on the altar and remember that someone is angry with you, leave your gift there....Make peace with that person, then come back and offer your gift to God (Matthew 5:23-24). Is there someone you need to apologize to? Ill pray for you, that God will give you the courage and the grace, the right timing and the best words to do it. Even though doing the right thing is often difficult, its always good for the soul -- no if, ands or buts about it.

Nancy Kennedy is the author of Move Over, Victoria - I Know the Real Secret, Girl on a Swing, and her latest book, Lipstick Grace. She can be reached at352-564-2927 or via email atnkennedy@chronicleonline.com.

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The anatomy of trade deficits – The News International

In the first 10 months of the outgoing financial year (FY 2017), a $19.93 billion trade deficit was registered on account of exports worth $17.91 billion and imports that amount to $37.84 billion. Trade deficit during the same period of the preceding financial year was $14.61 billion, with exports worth $18.14 billion and imports amounting to $32.75 billion. As a result, during FY 2017 (July 2016 till April 2017), trade deficit has increased by 36.41 percent compared with the previous year.

Trade deficit, along with fiscal deficit, has been a perennial feature of Pakistans economy as in the case of most other net petroleum-importing developing countries. The reasons for this stem from both economic and cultural factors. These economies need to import a great deal of capital equipment and industrial raw materials to maintain or accelerate the growth momentum.

Culturally, the people living in such societies are strongly inclined towards imitating a lifestyle that is prevalent in rich countries even though they lack the corresponding productive capacity which encourages the import of luxury goods. On the other hand, owing to severe supply-side constraints, coupled with a relatively large population, exports cant keep pace with imports.

It may be useful to compare Pakistans foreign trade performance with that of two other countries in the region over last three years. In FY 2014, Pakistans trade deficit was $16.59 billion (exports amounting to $25.07 billion and imports worth $41.66 billion), which went up to $17.20 billion in FY 2015 (exports worth $24.08 billion exports and imports amounting to $41.28 billion). The deficit further increased to $18.48 billion in FY 2016. The exports worth $21.97 billion while imports stood at $40.45 billion.

India registered a trade deficit worth $141.82 billion in 2014, with export amounting to $317.54 billion and imports worth $459.36 billion. The deficit came down to $126.36 billion ($264.38 billion for exports and $390.74 billion for imports) in 2015 and fell further to $96.37 billion in 2016 (exports worth $260.32 billion and imports amounting to $356.70 billion). Likewise, in the case of Sri Lanka, trade deficit stood at $7.94 billion (exports amounting to $11.29 billion and imports worth $19.24 billion) in 2014. It went up to $8.52 billion (with exports worth $10.43 billion and imports at $18.96 billion) in 2015 and rose further to $8.95 billion (exports amounting to $10.54 billion and imports worth $19.50 billion) in 2016.

It is evident that all the three countries are running an adverse trade balance and its scale is understandably relative to the size of the economy the biggest for India and the smallest for Sri Lanka. Trade deficit has gone up for both Pakistan (11.4 percent) and Sri Lanka (12.7 percent) over last three years. But in the case of India, it has come down. Imports have come down for both Pakistan (marginally by 2.9 percent) and India (largely by 22.3 percent), with a small increase for Sri Lanka. Exports have come down for each of the three countries: 12.4 percent for Pakistan, 18 percent for India and 6.6 percent for Sri Lanka. These figures reflect a reduction in global trade from $18.9 trillion in 2014 to $15.86 trillion in 2016.

The increase in trade deficit during FY 2017 (between July 2016 and April 2017) over the corresponding period of the preceding year may be explained by looking at both imports and exports. Total imports have gone up from $32.75 billion to $37.84 billion by 15.5 percent. Category-wise, the largest increase occurred in the transport sector by 39.2 percent, followed by the petroleum group (15.5 percent), food items (18.9 percent), machinery and capital equipment (16.1 percent), textiles (7.7 percent), chemicals (4.3 percent) and metals (1.7 percent).

Likewise, the total exports have gone down slightly from $18.14 billion to $17.91 billion by 1.3 percent. Exports fell in almost all important categories: textiles (3.2 percent), food items (4.5 percent), other manufactures, such as leather, sports and surgical goods (5.8 percent), petroleum (7.6 percent) and engineering goods (17.3 percent). However, the export of chemical and pharmaceutical products went up by 4.3 percent.

It follows that the fundamental cause of the substantial growth of trade deficit is the increase in imports rather than the decrease in exports. At the same time, it is exceedingly difficult for the government to check the growth in imports for one reason or another. The import basket can be divided into three categories: essential items, such as food and petroleum products; capital equipment and raw materials necessary for economic growth; and luxury goods.

Restricting the import of the first two categories is not desirable for obvious reasons. The government can restrict the import of luxury goods by raising the customs duties. Like other developing countries, Pakistan has a considerable gap between its bound (WTO) and applied import tariffs. However, the problem is that the demand for the luxury goods comes either from the government itself or the politically powerful affluent class. As a result, restricting their imports is a difficult proposition in a political sense.

Increasing exports is the right way to narrow the trade deficit. Obstacles to export promotion are of three types: market access, the high cost of doing business and structural constraints. The focus of the government and the private sector has been on overcoming the first and second obstacles. Over the last decade, Pakistan has been on a spree to conclude preferential trading arrangements (PTAs). However, most of the PTAs have caused imports to grow at a faster pace than exports. This has driven up trade deficits with PTA partners.

Bringing down the cost of doing business includes seeking exemptions from internal and border taxes, duty drawbacks, reducing interest rates, providing electricity at subsidised rates and keeping wages from increasing. From time to time, the government declares zero-ratings for the key export-oriented sectors and thereby exempts them completely from the GST. Earlier this year, a hefty export package, in the form of duty and tax remissions, was announced by the prime minister.

Lowering the cost of doing business and securing preferential access in foreign markets is important. But without addressing the structural constraints, an appreciable increase in exports is not possible. Unfortunately, the latter has been short-shrifted by both the government and the businesses.

Pakistan has a narrow export base. It is essentially an exporter of either primary products such as rice and fruits or of semi-manufactured goods such as textiles, garments and leather products. Not only are exports deficient in value addition, but they are also sold to the low-end of the market. The export basket being agro-based is subject to the vagaries of weather. A bad cotton crop as was witnessed during the current year can impact export receipts. The export profile reflects the dismal state of industrial development.

Another major structural problem is low labour productivity, mostly because human resource development has traditionally been a neglected area in Pakistan. The corporate sector works under the misconception that low wages are the key to competitiveness. Instead, what really matters is high labour productivity.

The corporate culture is markedly deficient in entrepreneurship one of the principal drivers of economic growth and export promotion. Most of the businesses are family-owned. They believe in playing it safe and making quick profits. These businesses are averse to innovation and venturing into new areas and have little commitment to improving quality. There is a culture of quality, which must be embedded into all the key processes of an enterprise: procuring supplies, putting together the factors of production, manufacturing products, marketing and sales. Making improvement in quality must be a continuous process.

Not surprisingly, Pakistan deficient as it is in both entrepreneurship and culture of quality continues to be an exporter of a narrow mix of low quality, low priced products.

The writer is a freelance countributor.

Email: [emailprotected]

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The anatomy of trade deficits - The News International

All the Awesome Awards the ‘Grey’s Anatomy’ Stars Have Won – Wetpaint

By now, were familiar with the Greys Anatomy casts victories at the Emmys, the Golden Globes, and the Peoples Choice Awards. (The people, in particular, love them some Greys.)

But those high-profile award shows aside, the actors have also earned their own unique honors, and those are the ones were celebrating in this photo gallery!

Greys Anatomy returns for Season 14 this fall on ABC.

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The Grey of Greys Anatomy has won three Peoples Choice Awards over the years, but she also won the Special Achievement in Entertaining honor from the National Italian American Foundation in 2007. Ciao bella!

For his work in Season 10, when Alex reconnected with his drug-addict father, Justin received the 2014 PRISM Award for Performance in a Drama Series Multi-Episode Storyline.

The awards show recognizes the accurate depiction of drug, alcohol, and tobacco use and addiction in film, television, interactive, music, DVD, and comic book entertainment.

Chandra won a PRISM Award the same year as Justin and she also has three Image Awards, two BET Awards, and a SAG Award under her belt.

But this actress also won a Theatre World Award way back in 1991 for her performance in the Off-Broadway play The Good Times Are Killing Me.

James won Outstanding Supporting Actor in a Drama Series at the Image Awards in 2012, and hed been nominated in that category for seven consecutive years by that point.

In 1998, a decade before setting foot in the hospital then known as Seattle Grace, Kevin won the International Fantasy Film Award for Best Actor for his role as a cuckolded husband in the film The Acid House.

Jesse was honored with the 2016 BET Humanitarian Award, and his impassioned speech captivated the audience and had America talking (and cheering) for days afterward.

In case you werent aware, Camilla is the latest voice of Lara Croft, and her work on Rise of the Tomb Raider won her a Behind the Voice Actors Award in 2016 in the Best Female Lead Vocal Performance in a Video Game category.

Caterina won a PRISM Award, too accepting the award in 2012, back when she was starring on Greys spin-off Private Practice and plumbing the depths of Amelia Shepherds addiction.

The Alliance for Women in Media Foundation bestowed Debbie with the Lifetime Achievement Award at their Gracie Awards on June 6 and even better, real-life daughter Vivian Nixon and TV son Jesse Williams presented the honor.

[Women] have a real purpose and a real point of view thats very different, she told Variety at the event. By nature, we are the ones that nurture, stand up, and fight.

By now, were familiar with the Greys Anatomy casts victories at the Emmys, the Golden Globes, and the Peoples Choice Awards. (The people, in particular, love them some Greys.)

But those high-profile award shows aside, the actors have also earned their own unique honors, and those are the ones were celebrating in this photo gallery!

Greys Anatomy returns for Season 14 this fall on ABC.

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All the Awesome Awards the 'Grey's Anatomy' Stars Have Won - Wetpaint

Grey’s Anatomy Season 13: Best Relationship, Worst Episode & More! – TV Fanatic

For better and for worst,Grey's Anatomy Season 13 has been one of the most talked about seasons of the series.

After 13 seasons, that's quite the accomplishment. There were some ups, many unfortunate downs, and so much fighting.

There were some great guest -stars, some interesting love triangles, and many character-centricepisodes that slowed things down and honed in on a select few.

Season 13 also saw the directorial debut of Ellen Pompeo, herself, as well as Kevin McKidd, Debbie Allen, and Chandra Wilson.

One thing is for sure, a lot of feelings were invoked throughout this season. Now, whether they were good, bad, or downright ugly is an entirely different observation to make. You can sound off about that below, but first, check out our TV Fanatic Report Card of Grey's Anatomy'sthirteenth season.

Want to relive every deliciouslysoapy moment? You can watch Grey's Anatomy online right here via TV Fanatic!

Meredith has had her fair share of questionable moments (that entire situation with Maggie, threatening DeLuca etc.,), but for the most part, she's greatly improved this season. She's been a competent, capable doctor. She has stood by her beliefs, challenged Bailey, and been a supportive friend to both Alex and Nathan. We also saw her grow as a woman and a sister. It's been amazing watching the 180 she's done when it comes to supporting and protecting her family, and accepting family she never would have accepted years ago. It was also nice to see her be willing to move on from Derek without feeling guilty about it. Meredith has matured as a character, and she's all the better for it.

Eliza Minnick will go down in the books as one of the most polarizing characters in Grey's Anatomy history. You either loved her or loathed her, with very few who fell in between. Eliza and her infamous Minnick Method clashed with nearly everyone. The only one who seemed to truly enjoy her was Arizona. Her days at Grey Sloan were tumultuous at best, but she finally pushed people too far when she didn't alert authorities about an endangered resident, and since the residents were her job, well, she ended up losing hers. So long, Minnick.

Honestly, how many times has Alex been put into a slot like this? We've lost count. Season 13 was SUPPOSED to be the season of Originals. While that failed on multiple levels, the worst of it was how underutilized Alex was. It's true that he dealt with the trial at the beginning of the season, but he virtually disappeared for the rest of it. The show went multiple episodes without even seeing or mentioning him. The back half of the season he abruptly tracked down Jo's husband in the most erroneous storyline in a season chocked full of them, but nothing came from it. He barely had a line in the season finale. Hopefully, he will not find himself in this category again next season.

Nathan has gone from the arrogant outcast to a great doctor, yes, but a supportive friend. His persistent pursuit of Meredith was offputting at times, but he made up for it in his softer, serious moments. He was supportive of Meredith processing her grief, but also, he has proven to be a great, supportive friend to Maggie despite the love triangle issue, and he's been on better terms with Owen as well. We got to peel back the layers of Nathan Riggs, and now that Megan has returned, we expect to see even more. Looking forward to it!

The Arizona we're most familiar with checked out earlier in the season, sometime after comforting DeLuca upon his return to the hospital. We haven't seen much of the woman that we love since. She was inconsistent and flaky all season. Not to mention the majority of her relationship with Eliza had her inexplicably coming across like a total horn-dog. She was amazing in season 12. What happened to the Arizona who stuck by her set of morals and was protective of her friends? We're not used to Arizona appearing so one-dimensional.

Through the good, bad, and annoying, there was one character that consistently shined every single time. That character was Ben Warren. He became a bit of an audience surrogate saying exactly what we were probably yelling at the screen and reacting the same way we were reacting. Whether it was being brutally honest with his colleagues, calling his wife out on her mistakes, rocking his surgeries with virtually no help, or running into a burning building to save his friend, Ben Warren was a rockstar all season long. Somebody had to be the mature one around there.

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Grey's Anatomy Season 13: Best Relationship, Worst Episode & More! - TV Fanatic