At the ripe age of 23, Crystal Vander Zanden is a newly minted CSU Ph.D. – Source

Most college students finish their undergraduate degrees around the age of 22. But Crystal Vander Zanden isnt most students.

The 23-year-old Arizona native is leaving Colorado State University a newly minted Ph.D. in biochemistry the youngest ever from the Department of Biochemistry and Molecular Biology.

The soft-spoken, unassuming Vander Zanden defended her Ph.D. thesis in June, and is now packing up her apartment in Fort Collins after spending six years working toward her doctorate. In the fall, she will begin a National Institutes of Health-fundedpostdoctoral fellowshipat the University of New Mexico. There, shell conduct research on biophysical characterization of Alzheimers Disease-related protein aggregation, while also teaching courses at a local community college.

Growing up in Glendale, Arizona, Vander Zanden was home-schooled an environment in which she quickly advanced at her own pace. At age 8, she asked her mother if she could enroll in a biology course. After passing an entrance exam, Vander Zanden took her first college-level course at Glendale Community College, at the age of 9. At age 13, she graduated from Glendale High School.

She went on to Nebraskas Doane University (then Doane College), majoring in biochemistry. She was a student researcher in the lab of Assistant Professor Erin Wilson, studying the biochemical properties of protein adsorption in bone. While in college, her family mom, stepdad and younger siblings all moved to Nebraska.

Choosing CSU to pursue a Ph.D. was a no-brainer for Vander Zanden, who was 17 when she visited Fort Collins for the first time and interviewed for the graduate program. She fell in love with campus, and with the small, close-knit biochemistry department. She chose CSU over two other Ph.D. programs.

People were laid back, but still doing fantastic science, she said.

Before she turned 18, Vander Zanden began her Ph.D. under the mentorship of Professor Shing Ho. With Ho, she learned how to think as an independent scientist, to come up with her own questions, and to figure out whats interesting about the data youve just collected.

Her Ph.D. examined the mechanics and functions of a DNA marker called hydroxymethylcytosine. The marker plays an important role in DNA recombination, the process by which damaged DNA fixes itself.

Ho said when Vander Zanden first joined his lab, she was put on a project about halogen bonding. Soon after, he asked her to change focus to the new study on which she would eventually write her thesis for determining hydroxymethylcytosines role in recombination. This switch required Vander Zanden to learn techniques Hos lab was not expert in, and to create an entirely new research direction.

It took determination and real courage as a scientist to take this leap of faith, and I could not imagine any other student of her age, or any age, taking on such a challenge, Ho said.

A compassionate individual and a source of intellectual and emotional support for many, Vander Zanden has earned the respect of students, faculty and others around her, Ho said. It has been a genuine honor to have played a part in helping Crystal find her passion in science and in teaching these past six years.

During her time at CSU, Vander Zanden received a National Institutes of Health pre-doctoral fellowship, and also received the College of Natural Sciences Graduate Student Excellence in Teaching Award. At the time, Vander Zanden was a teaching assistant in two courses, including physical biochemistry among the most challenging of undergraduate courses for biochemistry majors.

Vander Zanden said she routinely had 10 or more students crammed into her graduate student space during office hours. And it was through these types of experiences that she discovered how much she enjoys teaching.

It was an awesome thing to teach students until they actually understood something, and they felt empowered within themselves, Vander Zanden said.

She is also not one to take education and the opportunities she has embraced lightly.

Education is one of the only means we have in our society to do better than our parents, she said. Its an amazing thing and I want to be a part of that.

When Vander Zanden first applied to the Ph.D. program at CSU, her mom came with her, because Vander Zanden was not technically an adult. Besides some minor social setbacks with being under the legal drinking age for most of her time here, being younger has not been a major factor, with her peers or her students.

Though, driving was an issue in undergrad, she recalls. I was able to drive the same year everyone in my class was able to drink.

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At the ripe age of 23, Crystal Vander Zanden is a newly minted CSU Ph.D. - Source

MCI urged to review stand over signing lab reports – India.com

New Delhi, July 5 (IANS) The National M.Sc. Medical Teachers Association (NMMTA) on Wednesday urged the Medical Council of India (MCI) to review its notification that require the diagnostic laboratory reports to be signed by a doctor.

The NMMTA said India has shortage of specialist doctors to work in diagnostic laboratories and this deficiency can ably be compensated by the trained medical M.Sc. degree holders.

The recent letter written by the Medical Council of India (MCI) to the National Accreditation Board for Testing and Calibration Laboratories (NABL) regarding eligibility to sign diagnostic laboratory reports has not gone down well with the biomedical scientists possessing medical M.Sc. degree, NMMTA President Sridhar Rao said.

Currently, the document 112 of NABL provides authorised signatory roles for medical M.Sc. degree holders in the disciplines of microbiology and biochemistry.

Apparently, under the pressure from non-clinical doctors, the NABL was pressurised to exclude non-doctors from this role. The NABL sought the MCIs opinion. After a delay of nearly three years, the MCI replied that all lab reports should be signed/counter-signed by persons registered with MCI/State Medical Councils, Rao said.

He said this is in stark contrast to its previous stand.

In 2005, the members of the Ad hoc Committee appointed by the Supreme Court and of the Executive Committee of the MCI had approved the decision of the Ethics Committee that M.Sc. (Medical Biochemistry) is entitled to independently sign a medical biochemistry report in a clinical laboratory, he said.

Rao said the biomedical scientists are held in high esteem worldwide and allowed to sign reports.

The NMMTA said it would meet Prime Minister Narendra Modi and Health Minister J.P. Nadda to convince them the importance of biomedical scientists in the diagnostic laboratories.

This is published unedited from the IANS feed.

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MCI urged to review stand over signing lab reports - India.com

Two more Nevisian youths benefit from MUA/NIA Scholarship – The St. Kitts-Nevis Observer

Photo 1: Medical University of the Americas/Nevis Island Administration Scholarship recipients Oresia Stapleton and Yolinda Liburd at the legal departments conference room July 5.

Photo 2: The Hon. Mark Brantley, deputy premier of Nevis and minister of health, interacts with the 2017 Medical University of the Americas/Nevis Island Administration Scholarship recipients Oresia Stapleton and Yolinda Liburd July 5.

Photo 3: Nicole Slack-Liburd, chair for the Medical University of the Americas/Nevis Island Administration Scholarship Committee and permanent secretary in the Ministry of Health, stands with scholarship awardees Oresia Stapleton and Yolinda Liburd, the Hon. Mark Brantley and committee member Shelisa Martin-Clarke July 5.

Two more Nevisian youths benefit from MUA/NIA Scholarship

From NIA

CHARLESTOWN, Nevis Oresia Stapleton and Yolinda Liburd join the list of students who benefit from the Medical University of the Americas/Nevis Island Administration (MUA/NIA) Scholarship, a facility available since 1998.

They were announced as the annual scholarships awardees for 2017 by Nicole Slack-Liburd, chairperson for the MUA/NIA Scholarship Committee and permanent secretary in the Ministry of Health, on July 5.

Stapleton will be pursuing a bachelor of science degree in pre-radiologic technology at Midwestern State University in Texas.

Liburd will be pursuing a bachelor of science degree in biochemistry at the University of the West Indies in Jamaica.

The recipients spoke of what the opportunity meant to them and to thank their benefactors.

My life-long dream of attending university is finally moving forward, Stapleton said. Skilled radiographers and radiologists train in cutting-edge equipment are imperative in the continuous development in the quality of health care in our island. Benefactors like you make dreams become a reality. I am proud to say that my dreams are slowly unfolding and I am excited to begin a new career journey. Sincere thanks for enabling this opportunity. Your generosity truly makes an immeasurable difference in the advancement of my career path.

Liburd thanked God for what she described as a life-changing opportunity and expressed gratitude for the opportunity.

Words cannot express how grateful I am, she said. After I have completed my tertiary education in biochemistry, I will then further with a masters in forensic science. The experiences gained will be used to benefit me and improve my development and my little island. I cannot stress how grateful I am for being granted this scholarship, which has lightened my financial burden immensely.

The Honourable Mark Brantley, deputy premier of Nevis and minister of health, commended the recipients and offered them words of advice regarding overseas studies.

I ask that you would simply have your wits about you and that you pay attention, he said. I think you are both talented enough to not only maintain a 3.0, but to do much better than that. So, I encourage both of you. I congratulate both of you.

Brantley also told Stapleton and Liburd that the scholarship is an important privilege that they should not take for granted. He urged them to work hard to make themselves, their parents and the island of Nevis proud.

Since 1998, the scholarships have stemmed from a partnership with the NIA and the MUA for the provision of up to US$22,500 per annum for study opportunities in priority areas that are the needs of St. Kitts and Nevis.

Shelisa Martin-Clarke, a committee member of the MUA/NIA Scholarship Committee, was also present at the announcement. The other members of the committee are Ornette Herbert, acting permanent secretary in human resources; Palsey Wilkin, principal education officer; Kevin Barrett, permanent secretary in the Ministry of Education; Ron Daniel, youth representative; and Keisha Jones, private sector representative.

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Two more Nevisian youths benefit from MUA/NIA Scholarship - The St. Kitts-Nevis Observer

DNA testing – on the road to regenerative medicine – VatorNews

We recently had Dr. Craig Venter speak at our Splash Health 2017 event. Dr. Venter is the first person to sequence a human genome, simply put: the instructions and information about human development, physiology, and evolution. In his interview, he points out that 15 years ago, sequencing a human genome would have cost $100 million and take over nine months.

Oh how far weve come. Today, there are a number of companies helping us to analyze our genes, or basically our DNA, which make up genes, to understand our physiology. Advances in sequencing the human genome have been the foundation for this knowledge, and is ultimately paving the path toward personalized medicine - therapies that are personalized to a persons genetic code, and its cousin regenerative medicine - therapies that replace or enable damaged cells, organs to regenerate.

One company, Orig3n, is doing both. Boston-based Orig3n started out in 2014 collecting blood samples to conduct regenerative medicine studies, but later added in the ability to conduct DNA testing to learn more about a persons intelligence, or predisposition to learning languages, to knowing what vitamins theyre deficient in.

Its an interesting an unique funnel the company has created for itself on its way to solve big problems with regenerative medicine, which seems more in its infancy than DNA testing.

To that end, Orig3ns DNA testing business has taken off.

In order to be tested, you take a cotton swab and swab the inside of your cheek to collect DNA samples from the cells inside your mouth. Alternatively, one could spit in a tube, which is how 23andMe collects samples of DNA.

From there, Orig3n breaks down the cells to open up the DNA, which is inside the nucleus of the cell. The DNA is then purified and put into a genetic test panel. Your DNA is then analyzed against other DNA that have been collected and studied.

The analysis of the DNA is pretty standard. What differentiates its products, according to Robin Smith, Founder and CEO, is how the analysis is packaged and how quickly the results are turned around. The whole genome sequencing world has been around for 15 years and is fairly commoditized, said Smith. The same thing is happening with DNA detection. The biggest differentiator for Orig3n is that it delivers the data in ways that are understandable, said Smith.

For instance, on Orig3n, tests focus on an analysis of your skin to perfect your skincare routine, or about your strength and intelligence. Tests range from $20 to $100.

On Everlywell, you can take a DNA test to measure your sensitivity to foods. Or for around $239, it appears you can test to see if you have HIV, Herpes Type 2 and other sexual diseases.

On 23andMe, you can pay $199 to learn what proportion of your genes come from 31 populations worldwide, or what your genetic weight predisposes you to weigh vs an average and what are some healthy habits of people with your genetic makeup [though personally these habits seem to be good for anyone regardless of genetic makeup].

But for Orig3n, the DNA tests are just a good business while also a funnel to the bigger problem theyre trying to solve, and for which they recently raised $20 million for: Regenerative medicine.

Before offering the DNA tests, Orig3n was taking and continues to take blood samples, reprogramming cells to go back to a state three days prior. And from there, they can grow certain tissues. The purpose of Orig3n is to create cell therapies for various diseases and disorders.

In the next fives year, there will be real live therapies to repairing the degeneration of your eyes or performing some cardiac repair, Smith predicted. It feels like 1993 when I used a phone line to dial into the Internet, then seven years later we had the boom. We think regenerative medicine - getting your body to induce itself to rejuvenate parts that are broken - is where the Internet was in 1993.

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DNA testing - on the road to regenerative medicine - VatorNews

Psychopaths’ Brains Reveal Secrets of Their Immoral Behavior – Live Science

Psychopaths, with their superficial charms but lack of empathy, may act the way they do because their brains are wired to overvalue immediate rewards, a new study finds.

Psychopaths' brain wiring may also lead them to avoid thinking about the consequences of their potentially immoral actions, the study found.

Psychopaths are thought to make up about 1 percent of the general population and up to 25 percent of the prison population. Scientists who investigate psychopathy commonly define people with the disorder as having a lack of conscience or remorse, as well as impulsivity or a lack of self-control, shallow experiences of emotions, superficial charm and a grandiose sense of their own worth. [Understanding the 10 Most Destructive Human Behaviors]

More than three-quarters of incarcerated psychopaths are in prison because of a violent offense, according to a 2011 review of studies. Although not all psychopaths are violent, they can prove socially destructive in other ways, by lying, cheating and stealing, that review added.

"Psychopaths commit an astonishing amount of crime, and this crime is both devastating to victims and astronomically costly to society as a whole," Joshua Buckholtz, a neuroscientist and psychologist at Harvard University, said in a statement.

Scientific research into psychopathy "has for many years focused on emotion in particular, this idea that psychopaths are cold-blooded super-predators who lack the ability to experience emotions," Buckholtz told Live Science. In the new study, the researchers wanted to focus more on psychopaths' behaviors.

"Regardless of what they feel, they engage in a lot of behavior marked by a lack of self-control, and we were interested in the neuroscience of that poor decision making," he said.

Buckholtz and his colleagues brought a mobile MRI scanner on a tractor trailer to a pair of medium-security prisons in Wisconsin. They scanned the brains of 49 inmates as the prisoners took part in a delayed gratification test that asked them to choose between two options receiving a smaller amount of money immediately or a larger amount later. The researchers also had the inmates take a test to assess their level of psychopathy.

The researchers found that inmates who scored high for psychopathy showed greater activity in a brain region called the ventral striatum for the more immediate choice than those who scored lower in psychopathy. Previous studies suggested that the ventral striatum is linked with the ability to evaluate the value of different choices.

In addition, the scientists found that in psychopaths, the connection between the ventral striatum and another brain region known as the ventral medial prefrontal cortex were much weaker than normal. Prior work suggested that the ventral medial prefrontal cortex "is important for 'mental time travel' that is, thinking about the future consequences of actions," Buckholtz said. [10 Things You Didn't Know About the Brain]

These findings suggest that psychopaths often behave antisocially because their brains are wired in a way that makes them both overvalue immediate rewards and neglect the future costs of potentially immoral actions. In fact, the more abnormal inmates' brains were in both of these regards, the more crimes the prisoners were convicted of.

"The pattern of decision making we see in psychopathic individuals is not all that different from that in people with other kinds of self-destructive behavior, such as substance abusers, compulsive over-eaters or compulsive gamblers," Buckholtz said. "Whatever else may be going in psychopathy, such as deficits of emotion, our findings put psychopathy in the sphere of things that can be intervened in."

Future research can investigate whether there may be ways to help psychopaths improve their thinking about the future, such as through behavioral therapies or noninvasive brain stimulation, Buckholtz said.

The scientists detailed their findings online today (July 5) in the journal Neuron.

Original article on Live Science.

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Psychopaths' Brains Reveal Secrets of Their Immoral Behavior - Live Science

Driverless Cars Could Learn to Make Moral Choices – Courthouse News Service

FILE In this Tuesday, Dec. 13, 2016, file photo, an Uber driverless car waits in traffic during a test drive in San Francisco. In just a few years, well-mannered self-driving robotaxis will share the roads with reckless, law-breaking human drivers. The prospect is causing migraines for the people developing the robocars and is slowing their development. But experts say eventually the cars will coexist with human drivers on real roads. (AP Photo/Eric Risberg, File)

(CN) Is a self-driving vehicle capable of making moral decisions? If it is, which moral values should it use to make such choices?

These questions are among the issues society must consider as artificial intelligence, or AI, systems become more common in various industries, according to Gordon Pipa, co-author of a new study that provides a statistical model of human morality.

The research, published Wednesday in the journal Frontiers in Behavioral Neuroscience, is a breakthrough for efforts to equip AI systems with morality which experts had viewed as context-based and therefore impossible to describe mathematically.

But we found quite the opposite, said lead author Leon Sutfeld, a researcher at the University of Osnabruck in Germany. Human behavior in dilemma situations can be modeled by a rather simple value-of-life-based model that is attributed by the participant to every human, animal, or inanimate object.

In order to examine human behavior in road traffic scenarios, the team asked study participants to drive a car in a simulated, virtual-reality suburban neighborhood where they experienced unexpected, unavoidable dilemmas involving animals, inanimate objects and humans forcing the participants to prioritize which to save.

The authors then used the results to conceptualize statistical models that established rules, along with an associated degree of explanatory power to understand the observed behavior.

The findings come amid growing debate over the behavior of self-driving vehicles and other machines in unavoidable accidents.

Stakeholders and experts have operated under the assumption that human moral behavior could not be modeled, and have focused on outlining critical variables for engineering AIsystems. For example, a new initiative from the German Federal Ministry of Transport and Digital Infrastructure, or BMVI, has defined 20 ethical principles for self-driving cars.

Now that applying human morality to machines seems to be possible, the team argues that debate should now focus on how such morals are programmed into, and employed by, AI.

Now that we know how to implement human ethical decisions into machines we, as a society, are still left with a double dilemma, said senior author Peter Konig, a professor at the University of Osnabruck. Firstly, we have to decide whether moral values should be included in guidelines for machine behavior and secondly, if they are, should machinesact just like humans.

The team also warns that society is at the beginning of a technological revolution that requires clear rules. Without them, machines could begin making decisions without us.

In conclusion, Papa wonders: Should they imitate moral behavior by imitating human decisions, should they behave along ethical theories and if so, which ones and critically, if things go wrong who or what is at fault?

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Making ‘greenness’ human: UW lecture highlights environmentalism for the everyday student – Dailyuw

Urban environmentalist Jenny Price gave a lecture at the UW on July 3 in an attempt to help students and others understand how a change in human behavior can become a way of addressing environmental crises. The goal was to bring together the perspectives of urban environmentalism and the hard sciences with the humanities.

The lecture is a part of the summer institute City/Nature: Urban Environmental Humanities, which is sponsored by the Simpson Center for the Humanities and funded by the National Endowment for the Humanities (NEH). The institute provides UW scholars the opportunity to connect with other academics and provide professional development across disciplines. Price is visiting the university from Princeton.

The lecture addressed how to help environmentalists understand why people think and respond to environmentalism the way they do, as a way to address climate change. As important as technological or scientific solutions are, these solutions lack the ability to address social behaviors as a means of creating social change.

Its a critique about 21st century environmentalism, Price said when discussing her work and the book she is writing: Stop Saving the Planet 8 Other Tips for 21st-Century Environmentalists.

I really want to emphasize right up front that Im not critiquing all environmentalists, she said.

The frustration between environmentalists and those most affected by the negative effects of climate change as well as environmental damage aligns with the growing distance between humans and nature. Lower-income communities often fall into this gap.

There is a long American tradition that nature is a world that is away from humans, Price said.

This social distancing alienates what is in fact intertwined in the life of the city.

Environment is the very foundation of our lives, Price said.

Environmentalists and non-environmentalists alike need to change the notion that the planet needs to be saved, according to Price. She explained that the language of saving nature does not help people understand the environment as the center of their lives. How resources are accessed, controlled, and allocated brings nature squarely into the framework of community, class, and social change, she said.

Companies often use green initiatives to emphasize their care for environmental change, a characteristic Price calls green virtue. The result, Price said, is a corporation that maintains a high and mighty attitude, shifting responsibility off of their shoulders.

The responsibility then shifts to the public buying the product. These are who Price labels virtuous consumers, or those who carry the weight of environmental problems. She calls this trickle-down environmentalism.

What Price pointed out is that the people who are contributing least to environmental problems are often given responsibility for solutions solutions that happen to be expensive. This leaves the public angry, Prince continued, and antagonistic towards environmentalists and environmentalism.

The big question that hung in the air during the lecture was simple: how to make the responsibility for sustainability that of the government and large corporations.

According to Price, if the solution is salvation then environmentalists are missing 93 percent of environmental activities. She tracks this thinking through actions, policies, and solutions.

The environmental movement has not yet penetrated the popular discourse, Price said. Yet the concept of nature is deeply rooted in the way humans think, and incidentally making the environment the focus of a growing conversation paves the way toward social change. In the long run, this means environmental changes.

Its really about sustainable cities. Price said, when discussing what urban environmentalism is.

Preserving areas outside of the city has been the primary focal point of traditional environmentalism to date, but within the realm of urban environmentalism, the focus shifts to the city and how to create sustainability within it.

The long-term goal is to make urban environmentalism a common course in universities, fully integrating environmentalists perspectives within the hard sciences with the humanities.

UW Italian and French studies professor Richard Watts is not an environmentalist. At least, not in the literal sense of the word. Watts work has focused on the post-colonial world and he explores the social landscape of the places that France colonized.

However, he is heading the City/Nature: Urban Environmental Humanities institute.

One of the things I realized [was that] environmentalism was a constant in this literature and cinema, Watts said.

The intersection between the two fields created an avenue for art to act as a means of environmental change. The future of the environment, environmentalism, the role of the humanities and higher education merges in this seminar.

These summer programs bring some of the best and most creative minds in humanities fields together in real time to examine important subjects in depth and then seed the results of this process in classrooms and lecture halls around the country. NEHs Director of Education Programs Carol Peters said in an email.

The City/Nature institute will be running from June 26 to July 14 at the UW. According to the Simpson Center for the Humanities, the institute will offer participants the chance to engage in the development of an undergraduate course syllabus that is interdisciplinary. Visiting scholars will explore this approach in seminars and discussions.

Reach reporter Hannah Pickering at news@dailyuw.com. Twitter: Hannah_Pick95

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Gut Bacteria May Be Linked to Mood, Behavior in Healthy Humans – PsychCentral.com

Interactions between gut bacteria and the brain may play an important role in human health and behavior.

In a new study, researchers at the University of California, Los Angeles have discovered that microbiota in the gut interacts with brain regions associated with mood and behavior in healthy humans.The findings add to the growing body of evidence of a significant link between the gut and the brain.

Earlier studies have shown that microbiota, a community of microorganisms in the gut, can influence behavior and emotion. Rodent models have demonstrated the effects of gut microbiota on emotional and social behaviors, such as anxiety and depression, but there has been little scientific evidence in humans.

For the new study, the researchers wanted to identify brain and behavioral characteristics of healthy women clustered by gut microbiota profiles. A total of 40 women gave fecal samples for profiling, and magnetic resonance images were taken of their brains as they looked at images of individuals, activities, or other objects that evoked an emotional response.

The women were divided by their gut bacteria composition into two groups: 33 had more of a bacterium called Bacteroides; the remaining seven had more of the Prevotella bacteria.

Women in the Bacteroides group showed greater thickness of the gray matter in the frontal cortex and insula, brain regions involved with complex processing of information. These women also had larger volumes of the hippocampus, a region involved in memory processing.

In contrast, women in the Prevotella group displayed more connections between emotional, attentional and sensory brain regions and lower brain volumes in several regions, such as the hippocampus.

In this group, the womens hippocampus was less active as they looked at negative images. They also rated higher levels of negative feelings such as anxiety, distress and irritability after looking at photos with negative images than did the women in the Bacteroides group.

The new findings support the concept of brain-gut-microbiota interactions in healthy humans. Researchers still do not fully understand whether the bacteria in the gut influence the development of the brain and its activity when unpleasant emotional content is encountered, or if existing differences in the brain influence the type of bacteria that reside in the gut.

In either case, however, the findings could lead to important changes in how we perceive human emotions.

Source: University of California, Los Angeles Health Sciences

APA Reference Pedersen, T. (2017). Gut Bacteria May Be Linked to Mood, Behavior in Healthy Humans. Psych Central. Retrieved on July 5, 2017, from https://psychcentral.com/news/2017/07/05/gut-bacteria-may-be-linked-to-mood-behavior-in-healthy-humans/122846.html

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What moral code should your self-driving car follow? – Popular Science

Imagine you are driving down the street when two peopleone child and one adultstep onto the road. Hitting one of them is unavoidable. You have a terrible choice. What do you do?

Now imagine that the car is driverless. What happens then? Should the car decide?

Until now, no one believed that autonomous carsrobotic vehicles that operate without human control could make moral and ethical choices, an issue that has been central to the ongoing debate about their use. But German scientists now think otherwise. They believe eventually it may be possible to introduce elements of morality and ethics into self-driving cars.

To be sure, most human drivers will never face such an agonizing dilemma. Nevertheless, with many millions of cars on the road, these situations do occur occasionally, said Leon Stfeld, a researcher in the Institute of Cognitive Science at the University of Osnabrck and lead author of a new study modeling ethics for self-driving cars. The paper, published in Frontiers in Behavioral Neuroscience, was co-authored by Gordon Pipa, Peter Knig, and Richard Gast, all of the institute.

The concept of driverless cars has grown in popularity as a way to combat climate change, since these autonomous vehicles drive more efficiently than most humans. They avoid rapid acceleration and braking, two habits that waste fuel. Also, a fleet of self-driving cars could travel close together on the highway to cut down on drag, thereby saving fuel. Driverless cars will also encourage car-sharing, reducing the number of cars on the road and possibly making private car ownership unnecessary.

Improved safety is also an energy saver. [Driverless cars] are expected to cause fewer accidents, which means fewer cars need to be produced to replace the crashed ones, providing another energy savings, Stfeld said. The technology could help [fight climate change] in many ways.

The study suggests that cars can be programmed to model human moral behaviors involving choice, deciding which of multiple possible collisions would be the best option. Scientists placed human subjects into immersive virtual reality settings to study behavior in simulated traffic scenarios. They then used the data to design algorithms for driverless cars that could enable them to cope with potentially tragic predicaments on the road just as humans would.

Participants drove a car in a typical suburban neighborhood on a foggy day when they suddenly faced collision with an animal, humans or an inanimate object, such as a trash can, and had to decide what or whom to spare. For example, adult or child? Human or animal? Dog or other animal? In the study, children fared better than adults. The dog was the most valued animal, the others being a goat, deer and boar.

When it comes to humans versus animals, most people would certainly agree that the well-being of humans must be the first priority, Stfeld said. But from the perspective of the self-driving car, everything is probabilistic. Most situations arent as clear cut as should I kill the dog, or the human? It is more likely should I kill the dog with near certainty, or alternatively spare the dog but take a 5 percent chance of a minor injury to a human? Adhering to strict rules, such as always deciding in favor of the human, might just not feel right for many.

Other variables also come into play. For example, was the person at fault? Did the adult look for cars before stepping into the street? Did the child chase a ball into the street without stopping to think? Also, how many people are in harms way?

The German Federal Ministry of Transport and Digital Infrastructure attempted to answer these questions in a recent report. It defined 20 ethical principles for self-driving cars, several of which stand at odds with the choices humans made in Stfelds experiment. For example, the ministrys report says that a child who runs onto the road is more to blameand less worthy of savingthan an adult standing on the footpath as a non-involved party. Moreover, it declares it unacceptable to take a potential victims age into account.

Most peopleat least in Europe and very likely also Northern American cultureswould save a child over an adult or elderly person, Stfeld said. We could debate whether or not we want cars to behave like humans, or whether we want them to comply to categorical rules such as the ones provided by the ethics committee report.

Peter Knig, a study co-author, believes their research creates more quandaries than it solves, as sometimes happens in science. Now that we know how to implement human ethical decisions into machines we, as a society, are still left with a double dilemma, he said. Firstly, we have to decide whether moral values should be included in guidelines for machine behavior and secondly, if they are, should machines should act just like humans?

The study doesnt seek to answer these questions, only to demonstrate that it is possible to model ethical and moral decision-making in driverless cars, using clues as to how humans would act. The authors are trying to lay the groundwork for additional studies and further debate.

It would be rather simple to implement, as technology certainly isnt the limiting factor here, Stfeld said. The question is how we as a society want the cars to handle this kind of situation, and how the laws should be written. What should be allowed and what shouldnt? In order to come to an informed opinion, its certainly very useful to know how humans actually do behave when theyre facing such a decision.

Marlene Cimons writes for Nexus Media, a syndicated newswire covering climate, energy, policy, art and culture.

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What moral code should your self-driving car follow? - Popular Science

University faculty uncover how yeast cells react to stress, discover implications for humans – The Michigan Daily

University of Michigan researchers have found the first-ever early protection mechanism for cells under stress, reacting faster than the conventional gene expression pathways already known.

Using bakers yeast for the study allowed researchers to ask open-ended questions, since fundamental pathways in yeast have thus far been homologous to those in animal cells.Yeast is often used to study cellular biology for its simple structure.

Natsuko Jin,a researcher with the Life Sciences Institute and the first author of the study, explained the role of the newly-discovered mechanism in a press release, saying it was "like a first responder rushing to an alarm while the larger response team mobilizes."

The research findings, published in The Journal of Cell Biology, showed this first responder pathway helps yeast cells adapt to stress. In this study, specifically, cells under stress are those exposed to an environment of high salt concentration, called "high osmolarity." The key role player in this early protection pathway is the production of lipid PI3,5P2, which increases within five minutes of salt exposure.

The findings encompass eight years of research at the University Life Science Institute. Though it has been long-known in the field that PI3,5P2 spikes in response to stress,Jin pursued research of this realm because prior to this study, the physiological role of PI3,5P2 was unknown. Her mentors encouraged her to explore the lipid and its biological implications. Though the study used yeast, Jin said its findings could apply to many other species.

Since many of key players in this early protection pathway have been conserved through humans, other mammals, plants and yeasts, this indicates that this and other types of early protection pathways may exist more broadly and may respond to different types of cellular stress in many species, Jin said.

Researchers went on to test what would happen if Fab1p, an enzyme that synthesizes PI3,5P2, was removed. They found over 80 percent of the yeast was dead in the high salt environment without Fab1p. On the other hand, when researchers removed the slower response pathway, only 30 percent died, demonstrating just how critical the newly discovered-pathway is to cell preservation.

LSA junior Susan Wager, a cellular and molecular biology major, found the study to be fascinating. As pre-med student, Wager was intrigued by the possible implications these findings have on the cells of animals, including humans.

I would be interested to see if these findings can be replicated on more complex cells, Wager said. If there is a first responder mechanism in human cells, imagine all the cell damage that could be prevented. This is potentially revolutionary in science research.

Researchers found kinases Pho85p and corresponding cyclin Pho80p do not make signaling lipid PI3,5P2, regardless of if the environment was of normal or high osmolarity. Rather, the findings showed, in high osmolarity, Pho85p phosphorylates Fab1p, which then goes on to synthesize PI3,5P2. Hence, Fab1p proves to be a major role player in this first responder pathway.

A similar rapid-response process also happens in the cells of mammals, prior to the conventional, long term pathway responding to high salt cell stress. Life Sciences Prof. Lois Weisman, the studys third author, found this promising for more complex forms of life.

Even in our own bodies, where our cells are more protected because we have all these different kinds of physiological regulations, we also experience stress, Weisman said. It interests me that that all along I believed, just like everyone else, that there was this relatively long-term protection mechanism ... and what we found is that theres actually this early protection mechanism.

As for the future for the Weisman lab, researchers will look at neurons to see if there is a similar first responder pathway present, homologous to yeast cells.

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University faculty uncover how yeast cells react to stress, discover implications for humans - The Michigan Daily