Getting tumors tested for genetics is the latest theory to help drugs target cancer – The Denver Post

Family photo provided by Katie Rosenbaum via AP

WASHINGTON Colon cancer. Uterine cancer. Pancreatic cancer. Whatever the tumor, the more gene mutations lurking inside, the better chance your immune system has to fight back.

Thats the premise behind the recent approval of a landmark drug, the first cancer therapy ever cleared based on a tumors genetics instead of the body part it struck first. Now thousands of patients with worsening cancer despite standard treatment can try this immunotherapy as long as genetic testing of the tumor shows theyre a candidate.

Its like having a lottery ticket, said Johns Hopkins oncologist Dr. Dung Le, who helped prove the new use for the immunotherapy Keytruda. Weve got to figure out how to find these patients, because its such a great opportunity for them.

Today, doctors diagnose tumors by where they originate breast cancer in the breast, colon cancer in the colon and use therapies specifically tested for that organ. In contrast, the Food and Drug Administration labeled Keytruda the first tissue-agnostic treatment, for adults and children.

The reason: Seemingly unrelated cancers occasionally carry a common genetic flaw called a mismatch repair defect. Despite small studies, FDA found the evidence convincing that for a subset of patients, that flaw can make solid tumors susceptible to immunotherapy doctors otherwise wouldnt have tried.

We thought these would be the hardest tumors to treat. But its like an Achilles heel, said Hopkins cancer geneticist Bert Vogelstein.

And last month FDA Commissioner Scott Gottlieb told a Senate subcommittee his agency will simplify drug development for diseases that all have a similar genetic fingerprint even if they have a slightly different clinical expression.

Its too early to know if whats being dubbed precision immunotherapy will have lasting benefits, but heres a look at the science.

WHOS A CANDIDATE?

Hopkins estimates about 4 percent of cancers are mismatch repair-deficient, potentially adding up to 60,000 patients a year. Widely available tests that cost $300 to $600 can tell whos eligible. The FDA said the flaw is more common in colon, endometrial and gastrointestinal cancers but occasionally occurs in a list of others.

Say, have I been tested for this?' is Les advice for patients.

MUTATIONS AND MORE MUTATIONS

Most tumors bear 50 or so mutations in various genes, Vogelstein said. Melanomas and lung cancers, spurred by sunlight and tobacco smoke, may have twice as many. But tumors with a mismatch repair defect can harbor 1,500 mutations.

Why? When DNA copies itself, sometimes the strands pair up wrong to leave a typo a mismatch. Normally the body spell checks and repairs those typos. Without that proofreading, mutations build up, not necessarily the kind that trigger cancer but bystanders in a growing tumor.

THE PLOT THICKENS

Your immune system could be a potent cancer fighter except that too often, tumors shield themselves. Mercks Keytruda and other so-called checkpoint inhibitors can block one of those shields, allowing immune cells to recognize a tumor as a foreign invader and attack. Until now, those immunotherapies were approved only for a few select cancers Keytruda hit the market for melanoma in 2014 and they work incredibly well for some patients but fail in many others. Learning whos a good candidate is critical for drugs that can cost $150,000 a year and sometimes cause serious side effects.

In 2012, Hopkins doctors testing various immunotherapies found the approach failed in all but one of 20 colon cancer patients. When perplexed oncologists told Vogelstein, a light bulb went off.

Sure enough, the one patient who fared well had a mismatch repair defect and a mind-boggling number of tumor mutations. The more mutations, the greater the chance that at least one produces a foreign-looking protein that is a beacon for immune cells, Vogelstein explained.

It was time to see if other kinds of cancer might respond, too.

WHATS THE DATA?

The strongest study, published in the journal Science, tested 86 such patients with a dozen different cancers, including some who had entered hospice. Half had their tumors at least shrink significantly, and 18 saw their cancer become undetectable.

Its not clear why the other half didnt respond. Researchers found a hint, in three patients, that new mutations might form that could resist treatment.

But after two years of Keytruda infusions, 11 of the complete responders have stopped the drug and remain cancer-free for a median of eight months and counting.

Catherine Katie Rosenbaum, 67, is one of those successes. The retired teacher had her uterus removed when endometrial cancer first struck, but five years later tumors returned, scattered through her pelvis and colon. She tried treatment after treatment until in 2014, her doctor urged the Hopkins study.

Rosenbaum took a train from Richmond, Virginia, to Baltimore for infusions every two weeks and then, after some fatigue and diarrhea side effects, once a month. Then the side effects eased and her tumors started disappearing. A year into the study she was well enough to swim a mile for a Swim Across America cancer fundraiser.

Nothing else had worked, so I guess we could say it was a last hope, said Rosenbaum, who now wants other patients to know about the option.

___

This Associated Press series was produced in partnership with the Howard Hughes Medical Institutes Department of Science Education. The AP is solely responsible for all content.

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Getting tumors tested for genetics is the latest theory to help drugs target cancer - The Denver Post

Genetics of Canine Personality Traits – The Bark (blog)

The influence of genes on personality and behavior is of great interest to people who love dogs as well as to scientists studying the genetics of animal behavior. Since dogs personalities play a major role in their ability to function as our companions as well as to carry out a variety of tasks as working dogs, its important to understand the contribution of genetics on behavior. It is well established that genetics plays a large role, as evidenced by behavioral differences between breeds. Even substantial differences in behavior within breeds can be accounted for by genetic variation.

One of the challenges to studying behavioral genetics is that large sample sizes are required because there are so many factors that influence behavior (e.g. early environment, training methods, various lifestyle factors). To achieve adequately large sample sizes in research is both expensive and time consuming, sometimes prohibitively so. A recent study called Genetic Characterization of Dog Personality Traits took a creative approach to meet this challenge.

The scientists were interested in genetic contributions to personality, defined as individual consistency in behavioral responsiveness to stimuli and situations. Researchers took advantage of the substantial knowledge people have about their own dogs personalities to explore genetic contributions to personality traits. Their work shows that it is possible to detect genetic variation in dog personality traits by using questionnaires to collect large quantities of useful data.

In this recent study, researchers used the C-BARQ (Canine Behavioral Assessment Research and Questionnaire) as well as a separate questionnaire about demographics to study 1975 UK Kennel Club-registered Labrador Retrievers. The C-BARQ allowed each dog to be scored for the following personality traitsAgitated When Ignored, Attention-Seeking, Barking Tendency, Excitability, Fetching, Fear of Humans and Objects, Fear of Noises, Non-Owner Directed Aggression, Owner-Directed Aggression, Separation Anxiety, Trainability and Unusual Behavior.

The additional questionnaire collected data about the dogs age, coat color, sex, neuter status, housing, health status, exercise, daily exercise and the role of the dog. (The various roles were gun dog, show dog and pet dog.) To gather genetic information, the study took advantage of the dogs pedigrees, which involved 29 generations and 28,943 dogs. Further genetic data on the dogs were obtained as part of a different study using standard genomic methods and genetic markers, with 885 dogs from that study also participating in the C-BARQ portion of the research. In the analysis, the researchers estimated heritability of personality traits based on both the pedigree and on the genomic data.

The researchers found that fetching has a higher heritability rating than any other personality trait. Interestingly, some previous studies have lumped trainability with fetching ability, which results in lower heritability scores for both of them. This study also revealed a considerable genetic component to the fear of noises. Aggression directed towards owners showed no genetic component at all, while aggression towards strangers had a moderate genetic component.

Many behavioral traits are polygenic (influenced by a large number of genes, with each one often having a small effect) and also have significant environmental influences, which means that it is difficult to determine genomic associations. Estimates of heritability are likely to increase with technological advances in genetic work.

The importance of this study is that it shows that genetic variance can be detected and studied with the use of questionnaires filled out by owners. It also reveals that grouping responses into behavioral factors may make it harder to detect the genetic influence on various traits.

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Genetics of Canine Personality Traits - The Bark (blog)

Interleukin Shutting Down Genetic Testing Program, Lays Off Staff – GenomeWeb

NEW YORK (GenomeWeb) Interleukin Genetics on Monday announced that it would suspend its genetic testing program for severe gum disease and elevated systemic inflammation over the next 60 days after it was unable to defer a debt payment.

The Waltham, Massachusetts-based firm said it would also lay off five employees, or 63 percent of its current workforce. The decisions come as the company pursues strategic alternatives, Interleukin CEO Mark Carbeau said in a statement.

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Interleukin Shutting Down Genetic Testing Program, Lays Off Staff - GenomeWeb

Genetics causing arthritis possibly helped humans survive Ice – Kasmir Monitor

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Genetics causing arthritis possibly helped humans survive Ice - Kasmir Monitor

Medical Physiology – 9781455743773 | US Elsevier Health Bookshop

I Introduction

Chapter 1 Foundations of Physiology

II Physiology of Cells and Molecules

Chapter 2 Functional Organization of the Cell

Chapter 3 Signal Transduction

Chapter 4 Regulation of Gene Expression

Chapter 5 Transport of Solutes and Water

Chapter 6 Electrophysiology of the Cell Membrane

Chapter 7 Electrical Excitability and Action Potentials

Chapter 8 Synaptic Transmission and the Neuromuscular Junction

Chapter 9 Cellular Physiology of Skeletal, Cardiac, and Smooth Muscle

III The Nervous System

Chapter 10 Organization of the Nervous System

Chapter 11 The Neuronal Microenvironment

Chapter 12 Physiology of Neurons

Chapter 13 Synaptic Transmission in the Nervous System

Chapter 14 The Autonomic Nervous System

Chapter 15 Sensory Transduction

Chapter 16 Circuits of the Central Nervous System

IV The Cardiovascular System

Chapter 17 Organization of the Cardiovascular System

Chapter 18 Blood

Chapter 19 Arteries and Veins

Chapter 20 The Microcirculation

Chapter 21 Cardiac Electrophysiology and the Electrocardiogram

Chapter 22 The Heart As a Pump

Chapter 23 Regulation of Arterial Pressure and Cardiac Output

Chapter 24 Special Circulations

Chapter 25 Integrated Control of the Cardiovascular System

V The Respiratory System

Chapter 26 Organization of the Respiratory System

Chapter 27 Mechanics of Ventilation

Chapter 28 Acid-Base Physiology

Chapter 29 Transport of Oxygen and Carbon Dioxide In the Blood

Chapter 30 Gas Exchange in the Lung

Chapter 31 Ventilation and Perfusion of the Lungs

Chapter 32 Control of Ventilation

VI The Urinary System

Chapter 33 Organization of the Urinary System

Chapter 34 Glomerular Filtration and Renal Blood Flow

Chapter 35 Transport of Sodium and Chloride

Chapter 36 Transport of Urea, Glucose, Phosphate, Calcium, Magnesium, and Organic Solutes

Chapter 37 Transport of Potassium

Chapter 38 Urine Concentration and Dilution

Chapter 39 Transport of Acids and Bases

Chapter 40 Integration of Salt and Water Balance

VII The Gastrointestinal System

Chapter 41 Organization of the Gastrointestinal System

Chapter 42 Gastric Function

Chapter 43 Pancreatic and Salivary Glands

Chapter 44 Intestinal Fluid and Electrolyte Movement

Chapter 45 Nutrient Digestion and Absorption

Chapter 46 Hepatobiliary Function

VIII The Endocrine System

Chapter 47 Organization of Endocrine Control

Chapter 48 Endocrine Regulation of Growth and Body Mass

Chapter 49 The Thyroid Gland

Chapter 50 The Adrenal Gland

Chapter 51 The Endocrine Pancreas

Chapter 52 The Parathyroid Glands and Vitamin D

IX The Reproductive System

Chapter 53 Sexual Differentiation

Chapter 54 The Male Reproductive System

Chapter 55 The Female Reproductive System

Chapter 56 Fertilization, Pregnancy, and Lactation

Chapter 57 Fetal and Neonatal Physiology

X Physiology of Cells and Molecules

Chapter 58 Metabolism

Chapter 59 Regulation of Body Temperature

Chapter 60 Exercise Physiology and Sports Science

Chapter 61 Environmental Physiology

Chapter 62 The Physiology of Aging

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Medical Physiology - 9781455743773 | US Elsevier Health Bookshop

Department of Physiology

The Department of Physiology has a long-standing tradition of excellence. Our faculty, trainees, and staff seek to understand how the human body works from the head down to the toes and everything in between. Together, we exploit the range of available model systems to understand physiological processes at a mechanistic and integrated level in health with the explicit goal of understanding human disease and identifying potential therapeutics.

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Kinesiology professor earns distinguished lectureship award from the American Physiological Society – Manhattan Mercury (subscription)

David C. Poole, professor of exercise physiology and co-director of the Cardiorespiratory Exercise Laboratory in the kinesiology, and anatomy and physiology departments, will receive the Edward F. Adolph Distinguished Lectureship Award from the Environmental and Exercise Physiology, or EEP, section of the American Physiological Society.

The award and lecture will be presented at the Experimental Biology meeting in San Diego in April 2018. The award recognizes an eminent research scholar who has made meritorious contributions to the areas of environmental, exercise, thermal or applied physiology and who also is an outstanding public speaker.

Pooles research examines the limitations in the oxygen transport pathway especially at the muscle microcirculatory level. This work has been funded by the National Institutes of Health for more than 20 years. Discoveries made by Poole and his colleagues and students have helped inspire and drive major clinical trials advancing novel therapeutic treatments to reduce morbidity and mortality in heart failure patients in the U.S. and worldwide. This work also is germane to understanding the limitations to athletic performance and the exercise intolerance that develops with aging. He has authored three books and numerous chapters in major academic textbooks and regularly presents his work before national and international scientific audiences.

Poole began his higher education in England, where he earned his bachelors degree with honors in applied physiology and sports science from Liverpool Polytechnic. His masters degree and doctorate are from University of California, Los Angeles in kinesiology specializing in physiology. He was awarded the higher Doctor of Science in physiology from John Moores University in Liverpool, which recognized his outstanding contributions to the field. He was the first recipient of that award, which was conferred by the British first lady, Cherie Booth Blair.

Pooles career is filled with recognition and awards in grants, for research and, most importantly, for his teaching and research with students. He is extensively published with more than 200 peer-reviewed papers in journals such as Circulation Research, Journal of Clinical Investigation, Respiration Physiology and Neurobiology, European Journal of Applied Physiology, American Journal of Physiology and the Journal of Applied Physiology. This work has been cited more than 14,000 times in the scientific literature as well as featured on television, newspaper articles and syndicated radio networks.

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Kinesiology professor earns distinguished lectureship award from the American Physiological Society - Manhattan Mercury (subscription)

Can Breathing Like Wim Hof Make Us Superhuman? – Discover Magazine (blog)

(Credit: Innerfire BV)

Take a deep breath. Feel the wave of nitrogen, oxygen and carbon dioxide press against the bounds of your ribcage and swell your lungs. Exhale. Repeat.

Before consciously inhaling, you probably werent thinking about breathing at all. The respiratory system is somewhat unique to our bodies in that we are both its passenger and driver. We can leave it up to our autonomic nervous system, responsible for unconscious actions like our heartbeat and digestion, or we can seamlessly take over the rhythm of our breath.

To some, this duality offers a tantalizing path into our subconscious minds and physiology. Control breathing, the thinking goes, and perhaps we can nudge other systems within our bodies. This is part of the logic behind Lamaze techniques, the pranayamic breathing practiced in yoga and even everyday wisdom just take a deep breath.

These breathing practices promise a kind of visceral self-knowledge, a more perfect melding of mind and body that expands our self-control to subconscious activities. These may be dubious claims to some.

For Wim Hof, a Danish daredevil nicknamed The Iceman, it is the basis of his success.

Now approaching his 60s, Hof has run marathons barefoot and shirtless above the Arctic Circle, dove under the ice at the North Pole and languished in ice baths for north of 90 minutes all feats that he attributes to a special kind of breathing practice.

You can easily try it for yourself. While sitting in a comfortable place, take 30 quick, deep breaths, inhaling through your nose and exhaling through your mouth. Then, take a deep breath and exhale; hold until you need to breathe in. Inhale again, as deep as you can, and hold it for 10 seconds. Repeat as many times as you like.

Combined with repeated exposure to the cold, Hof says that his method will lead to tangible health benefits: more energy, lowered stress levels and an improved immune system. For him, it enables seemingly superhuman feats of endurance, brought on, he says, by the physiological changes that his breathing techniques impart.

(Credit: Innerfire BV)

Breathe properly, Hof claims, and oxygen levels in the tissues increase and adrenaline floods the body, granting strength that we didnt know we had.

If you oxygenize the body the way we do it, the oxygen gets into the tissue. [Regular] breathingdoesnt do that, he says. What happens in the brain stem, the brain says, There is no oxygen anymore. Then it triggers adrenaline to shoot out throughout the body. Adrenaline is for survival, but this time it is completely controlled the adrenaline shoots out throughout the body and resets it to the best functionality.

Hof speaks convincingly of the heightened mind-body connection his technique engenders, begging comparisons toa long tradition of semi-mystic practices such as pranayamic yoga, tummo breathing and breathwork.

Over the phone, Hof is loquacious and utterly convincing, perhaps fitting for a man who ran up Mt. Everest shoeless and shirtless, trusting only his breath. He touts the multiple scientific studies hes been involved with, while tossing mentions of mitochondrial activity, blood alkalinity and adrenaline in a flurry of scientific buzzwords.

Above all, he speaks of a more profound connection between mind and body that allows us to quell the primal desire to run from pain and fear or from the cold.

I found by deeper breathing, going into the cold, thinking about it, dealing with it; getting the conviction that my ability to breathe deeper is making connections with my body, he says. If you go into the ice cold you have to go deep. There is no other way. It is just bloody cold.

This mindset aligns with the core tenets of yoga and other practices that aim to grant us more control of our physiology. Breath control is at the center of many of these techniques, and the concept has worked its way into modern medicine as well.

Robert Fried is a clinical respiratory psychophysiologist who retired from the Biopsychology and Behavioral Neuroscience Program at the City University of New York in 2010. Hes also written several books on how breathing is related to stress levels and our physiology. In his practice, Fried worked with individuals whose medical conditions made it difficult to breathe, such as COPD patients, as well as people whose lives or professions left them chronically stressed, and his methods essentially involve

The purpose of deep breathing is to induce a hypometabolic state, where autonomic and mental arousal are minimal.It is a resting, restorative state, a counter anxiety, counter stress response of the body induced by using the breathing that goes with relaxation to trigger a similar muscle response in the body, Fried wrote in an email to Discover.

Its slowing us down, in other words, to counteract the damaging effects that prolonged stress can have on our bodies effects that are well known and generally accepted. Fried and therapists like himhave used conscious breathing techniques, similar to those found in yoga, for years, and have achieved reliable success. Fried mentions that many of his patients felt rejuvenated after just a few minutes of conscious breathing with him, which sounds similar to what Hof promises.

(Credit: Innerfire BV)

We can achieve noticeable physical effects with other breathing exercises as well, although they are almost all short-term. The valsalva maneuver, which involves exhaling while closing the throat, quickly lowers blood pressure and raises the pulse, and is used to help stabilize patients suffering from heart arrhythmias. The Lamaze breathing used by many pregnant women has been shown to increase pain tolerance and aid relaxation, while there have been many reports of hallucinations and feelings of euphoria following hyperventilation.

Despite the daredevil publicity stunts and enthusiastic salesmanship, perhaps Hof isnt so far outside of the norm after all. Perhaps we should simplyview his techniques as radicalized version of yoga, albeit one thats practiced in the middle of a Scandinavian winter.

Still, sitting in an ice bath for an hour and a half is nothing to scoff at. But can we really attribute extreme feats of endurance to the kind of simple exercises we can do while sitting at the office?

The crux of the issue may come down to the question of how well we truly understand the inner workings of the human body. And, though he may edge into hyperbole while discussing myriad benefits of his techniques, Hof has also proven willing to offer himself up as a scientific test subject.

The first true scientific evaluation of Hof came in 2014, when a team led by Danish researcher Mathijs Kox tested the immune systems of people who had followed Hofs training regimen for 10 days. Kox injected participants with an inflammatory agent while they performed the techniques. Compared to a control group, they experienced lower levels of inflammation, and were less affected by the fever and nausea that usually accompanies the injection.

While the researchers still have no solid theory as to why breathing and cold exposure seem to dampen immune activity, they suggest that the release of adrenaline breathing sparks could play a role. The spike in adrenaline was linked to increased levels of an anti-inflammatory protein, and decreased levels of proteins, called cytokines, responsible for signaling the immune system.

Hof being tested. (Credit: Innerfire BV)

There are a few caveats to the study, however. For starters, Koxs team hasnt yet tested the different components of the Hof technique separately, so its hard to say if hyperventilation, breath holding, cold exposure or some combination of all three is at play. In addition, Daniel Beard, a professor of physiology at the University of Michigan points out that their study fails to determine whether the effects are short- or long-term.

None of these people have control over their blood pH or their breathing, except when theyre actually consciously doing this thing. Their heart rates are the same as the other subjects, their pressures are the same, he says.In other words, the life-altering physiological changes that Hof claims exist could only materialize for the short time during which participants are actively doing the exercises.

A true test of the Hof method would determine whether its effects persist, even when people arent consciously altering their breathing. Beard does agree with their fundamental conclusions though, and acknowledges that something is indeed going on in people following Hofs method.

Clearly these people have altered their physiological state this training has changed them, and its changed them in a way that has to do with the autonomic nervous system, he says.

The study lends scientific credibility to Hofs claims and adds credence to the idea that conscious breathing can allow us to influence deeper processes in our bodies. As is perhaps to be expected, Hof goes one step further, positing that the surge in blood alkalinity that accompanies hyperventilationallows us to consciously train our cells, and, theoretically, optimize their machinery. Neurotransmitters in our blood vessels communicate with our brains and cells to regulate blood pH levels something that normally occurs without any intervention on our part. Hof believes that by taking control of our breath we can force open a doorway into these normally unconscious processes and hijack them to optimize how our bodies perform.

This is a more controversial proposition, given that trying to alter blood pH is essentially pitting us against ourselves. When our blood becomes alkaline it violates homeostasis, the perfect balance of internal conditions that our bodies strive to achieve. Hof says this is a good thing. Modernity has made us soft, he asserts, and instead of becoming healthier weve instead achieved a kind of degeneracy. Dunking ourselves in icy waters and breathing like were being chased by a starving tigerbrings about a body more in union, he says, and claims this translates to real health benefits.

(Credit: Innerfire BV)

This is where Hof begins to step beyond the edges of modern science into the cold, as it were. There is really no evidence to suggest making blood alkaline, even temporarily, is a good thing, andresearchers like Fried were skeptical about the possible benefits. The veracityof other physiological mechanisms Hof claims, such as oxygenating the blood and stimulating the immune system with cold are also unproven.

How then should we reconcile Hofs feats with the apparent flaws in his logic? A cynical read says that hesan unnaturally gifted individualexaggerating the limits of normal human physiology to profit from hopeful individuals. But, science wouldnt get very far if it was dominated solely by cynics. Is it possible that Hof has stumbled across a quirk of human physiology, one with with the potential to illuminate previously unseen pathways within our bodies?

Count Andrew Huberman in as one of the optimists.An associate professor of neurobiology and opthamology at Stanford University, Huberman is currently conducting a study that exposes practitioners of Hofs method to fearful encounters via virtual reality to see if their minds and bodies respond any differently.

His research focuses on how our bodies react to stressful situations, and after stumbling across the Wim Hof method a few years ago, Huberman set out to attempt a scientific exploration of the technique. Hes taken courses from Hof himself, and he says the experience convinced him that the breathing techniques were worth a closer look.

Huberman makes it clear that he has no financial ties to Hof, although he has lectured with him. He is, however, an enthusiastic practitioner of the breathing techniques he does them every morning, he says and has developed a theory to explain the calming and mildly euphoric sensations that result. The essence of the techniques, Huberman says, is inoculating our bodies against the stress response. And, as before, adrenaline is the key.

Normally, when adrenaline goes up cortisol goes up too and the hypothesis that were testing is that when you do this method, what ends up happening is you get an increase in adrenaline, but that cortisol, because youre in conscious control of your state, youre remaining calm, cortisol stays relatively low, he says.

From his own experiences, Huberman thinks that the use of hyperventilation and controlled breath-holding maximizes the beneficial effects of our innate stress response, while suppressing the negative long-term effects of stress.

This is a highly unusual situation. Youre kind of uncoupling the normal parallel response of these two hormone neurotransmitters, he says.

Instead of eliminating stress entirely, Huberman thinks that we can learn to twist it to our advantage and condition our bodies to respond in a positive way.

Hes in the early stages of research at the moment, and his project includes a wide-ranging collaboration with other researchers to test a full spectrum of physiological responses. His goal is to perform the kind of testing that will stand up to the intense scrutiny that Hofss claims inevitably provoke.

Key for Huberman will be separating myth from fact. Some breathing techniques common to yoga and lamaze may not confer any benefits for our bodies, and could in fact harm them, according to Fried. Breathing often comes as part and parcel of a larger set of practices, and separating it into its constituent parts can be difficult.

The ultimate goal, says Huberman, is to come up with even better breathing protocols than already exist by examining a range of established practices. Breaking various methods apart to see what works and what doesnt is simply good science.

Indeed, the initial results of the Kox study may indicate that Hubermans adrenaline-cortisol theory may not be totally correct. They found that Hofs cortisol levels actually spiked during their tests, as opposed to dropping as Huberman predicted they should. They didnt confirm similar results in their other test subject though, so the correlation remains ambiguous. In fact, all we can really sayat this point is that this kind of breathing helps release adrenaline into our bodies.

The perplexing power that breathing holds remains a mystery for the time being, even as the quantitative might of the scientific method is brought to bear upon it. Promising research is ahead, however, and Hof and others already hint at the possible rewards.

These studies might end up confirming once and for all what practitioners of yoga and other physical and mental practices have known intuitively for years. It may be that the duality of breath at once automatic and controllable runs even deeper. Its not just our lungs that we can consciously grasp hold of, its our physiology as a whole.

All we have to do is find the handle.

[Disclaimer: Neither Discover Magazine nor any of the researchers interviewed here endorse the Wim Hof method. If you choose to follow the breathing protocols, you do so at your own risk]

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Can Breathing Like Wim Hof Make Us Superhuman? - Discover Magazine (blog)

Taking A Second Look – ChicagoNow (blog)

By Jack Spatafora, Thursday at 10:21 am

The good news is that in this Internet age you and I will never have to be alone again. Or maybe when you think about it, this is actually the bad news. However you choose to think about it, being alone can be debated; but being lonely cannot. Loneliness is a killer.

C.S. Lewis put it best when he said: "Friendship is born in that moment when one person says to another: "What? You too? I thought I was the only one." Marcel Proust then completed the thought: "Let us be grateful to people who make us happy; they are the charming gardeners who make our souls blossom."

As is usually the case, some of us my age are perfectly willing to go with the solid insights of our best writers like Lewis and Proust. These, though, are very different times; now we seem to require additional scientific evidence. Not to worry -- a thousand neurobiologists to the rescue!

We are not saying science has no say in the matter of loneliness. But we are saying it needn't hog the show with its physiological data; for you see my physiology is not me anymore than I am my physiology. Take a recent scientific article in 'The New Republic' by Judith Shulevitz which observes: "We've known intuitively that loneliness hastens death; but haven't been able to explain how. Now we can show that loneliness sends misleading hormonal signals, rejiggers the molecules on genes that govern behavior, and wrenches a slew of other systems out of whack."

To know this much is to know this much. Although it alone is hardly to know loneliness. For the total tragedy of that experience you need more than even our most exquisite scientific explanations. You need to bury a spouse or a child or a parent. Or to travel the anguish in tales from 'The Odyssey' to 'Anna Karenina' to 'Look Homeward Angel.' Or to sing late into the night sad songs like 'My Old Kentucky Home,' 'My Buddy,' and 'Bridge Over Troubled Waters.'

Human loneliness is a feeling and feelings transcend physiology. If they don't, then you and I are simply the synergy of our complex body parts. Something this confirmed theist refuses to believe. And you....?

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Taking A Second Look - ChicagoNow (blog)

Every Pro-Lifer Should Know This One Scientific Chart – The Weekly Standard

Everyone who studied middle-school chemistry recognizes the prominent chart that hangs in classrooms and laboratories around the world: The Periodic Table of Elements contains the ingredients that make up the material universe and addresses the scientific question of what we are made of.

The fact that there is a popular chart that displays what the material universe is made of is powerful and illuminating. Even people who don't consider themselves science types remember some of the more popular compounds, such as H2O.

The Periodic Table reminds us that even some of the most profound questionssuch as what is the universe made ofhave simple, well-established answers.

There is another internationally established scientific chart that accurately addresses an equally essential matter: the question of when the life of a human being begins.

When the physical material dimension of a human beingan individual member of the human speciesnormally begins via sexual reproduction is a fundamental, relevant, and important scientific fact that everyone should know. While the details that human embryologists study are complex, the upshot is remarkably simple and has been documented for decades in the Carnegie Stages of Early Human Embryonic Development and the Carnegie Chart.

Carnegie Stage 1a marks the beginning of a human life.

While understanding the Periodic Table may have few practical applications for the average person, knowing about the Carnegie Chart is relevant to everyone. This empowering information is the very starting point for making informed decisions about human reproduction, about a human embryo and a human fetus, on an individual leveland more broadly speaking in terms of public policies and laws.

Yet, unlike the Periodic Table of Elements, the Carnegie Stages are not being taught in secondary schools and the Carnegie Chart is not hanging on the wall in science classrooms throughout America. And so, unless you are fortunate enough to be a scientist, you have probably never even heard of the Carnegie Chart.

For more than 70 years the field of human embryology (the branch of biology that specializes in the beginning of life and early development) has documented when a human life begins in the Carnegie Chart. Human embryologists view the Carnegie Stages and Chart as physicists view the Periodic Table, its their gold standard.

The Carnegie Chart contains the 23 Stages of development of the early human being during the embryonic period, beginning at fertilization and through slightly more than 8 full weeks post-fertilization. The Chart is based on the Carnegie Stages of Early Human Embryonic Developmentthe accurate, objective, and empirical scientific facts of human embryology that were instituted in 1942 by the National Museum of Health and Medicines Human Developmental Anatomy Center (a secular government organization that is a part of the National Institutes of Health). The Carnegie Stages are verified annually by a global committee of experts (called FIPAT) and are required to be included in every genuine human embryology textbook worldwide.

Human embryologists know that in normal human sexual reproduction a new, whole, individual, living human being begins to exist at the beginning of the process of fertilization (first contact between the plasma membrane of the sperm and the plasma membrane of the oocyte/"egg"), in a womans fallopian tube, and that the new human organism/human being is called a human embryo. This simple scientific fact is documented as Carnegie Stage 1a in the Carnegie Chart. (*The zygote is Stage 1c, by the way and is not when a human life starts).

When a human life begins is a fact that the scientific experts have known and documented for a very long time, and all of us should and can know too, because the Carnegie Stages and Chart are available to everyone, not just to human embryologists.

Brooke Stanton is the CEO of Contend Projects, a non-partisan, not-for-profit organization dedicated to spreading accurate scientific information about the start of a human life.

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Every Pro-Lifer Should Know This One Scientific Chart - The Weekly Standard