Biology

EvolutionaryScale Raises $142 Million To Transform Biology With AI – Finimize

Whats going on here?

EvolutionaryScale, an AI startup revolutionizing biology, just raised an impressive $142 million in seed funding.

What does this mean?

The funding round, led by industry stalwarts Nat Friedman, Daniel Gross, and Lux Capital, also secured significant backing from AWS and NVIDIAs venture arm. Josh Wolfe from Lux described this milestone as a 'ChatGPT moment for biology.' EvolutionaryScale's groundbreaking large language model, ESM3, aims to transform drug discovery and environmental engineering. Some models will be open-sourced for non-commercial research, while AWS and NVIDIA will support commercial use. EvolutionaryScale's innovative AI has already engineered a novel fluorescent protein, achieving evolutionary advancements that would have taken nature 500 million years.

Why should I care?

For markets: Pioneering the future of biotech.

This substantial investment signals strong confidence in AI's potential to revolutionize biotech. With major players like AWS and NVIDIA backing EvolutionaryScale, investors should watch how these technologies might drive significant growth in the biotech sector.

The bigger picture: AI, biology, and the next frontier.

AI's integration into biology is not just advancing drug discovery but also poised to address environmental challenges, like engineering microbes to break down plastic. However, this progress comes with caution, as generative AI's dual-use potential raises concerns about the creation of bioweapons.

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EvolutionaryScale Raises $142 Million To Transform Biology With AI - Finimize

Biology

Now you can get a bachelor’s degree in biology in Greenland – Polarjournal

The courses of the new biology curriculum is based on Greenlandic experiences and scientific findings. The course names are derived from Greenlandic names for seals or reindeer. Starting with 12 students, applications are open and the course will start on February 1st, 2025. Image: Daniel Lyberth Hauptmann

A new chapter is being added to Greenlands university history these weeks. For many years, educating biologists within the country has been a dream. A dream that has now come true.

Ilisimatusarfik and Greenland Institute of Natural Resources have jointly established a new bachelors degree in biology called SILA, which is now open for applications for admission to the course. The biology education is based in Nuuk. Many families in Greenland are lucky to have a relationship with hunting, fishing, and being out in nature. It is an obvious strength to build an education on, says Aviaja Lyberth Hauptmann, head of the department for the new SILA biology education. She adds: We have an enormous amount of biological knowledge in our society, so SILA aims to build on the knowledge people already have.

For Aviaja Lyberth Hauptmann, who holds a Ph.D. in microbiology, the story began in 2016 when she wrote a blog post. The post contained the first tentative ideas for what would later become SILA. The thoughts revolved around the idea that it would be ideal for Greenland to have a biology program that builds on the experience and skills many people in the population already possess. I come from a family and a culture where reindeer hunting is very significant. It dawned on me how much biological knowledge is needed for reindeer hunting and how great it would be to include hunting as part of an education, Aviaja Lyberth Hauptmann explains.

We are so excited. Who will be our students? How will this be for them? Will it be as good as we dream about?

Over the past three years, she has been responsible for fulfilling the dream of a Greenlandic biology program. And now we are finally here. We have created the program. We have a course called Tuttu (reindeer). And we will go reindeer hunting. Its quite touching to think about.

In addition to Tuttu, the semester plan also includes courses named Appa (thick-billed murre), Siku (ice), Puisi (seal), and Imaq (the sea). These courses are all based on Greenlandic reality. For Aviaja Lyberth Hauptmann and the rest of the SILA staff, its obvious why Greenland should be able to train its own biologists. Over 90 percent of our income in this country is based on living creatures from the sea. Its the fisheries that pay for our hospitals. Its the fisheries that pay for our daycare centers. So, of course, we need a population with the skills to understand the ecosystems we are a part of and who can manage them, Aviaja Lyberth Hauptmann states.

However, Aviaja Hauptmann Lyberth believes that the program is valuable not only for Greenlandic society but also for individuals. Education is about much more than just entering the job market. Education is also a process where people discover how to make a difference in the world. Not only by acquiring concrete tools but also by developing a critical sense and discovering who they are as a person, she says. So we want this program to build confidence in people.

With this in mind, they have made it possible for applicants to qualify for the program in various ways so everyone has equal opportunities to enter the program. There is room for the person who has achieved top grades in school and has always known they want to pursue something in the natural sciences. But there is also room for the group for whom the school system wasnt designed but who actually have a lot of biological knowledge and can contribute significantly to society, says Aviaja Lyberth Hauptmann. Therefore, Aviaja Lyberth Hauptmann and her colleagues will give the most weight to the motivated application when selecting the first students at SILA.

The first class at SILA has room for 12 students. The classes will take place in the Pikialaarfik building at Ilimarfik (the campus area in Nuuk), where the program is also located today. Applications are open now and until November 1. We are so excited. Who will be our students? How will this be for them? Will it be as good as we dream about? Aviaja Lyberth Hauptmann and her colleagues will find out on February 1, 2025, when the doors at Pikialaarfik open for the first students.

Text: Nicolline Larsen, Photos: Daniel Lyberth Hauptmann

Interested? Applicants can find all information here

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Now you can get a bachelor's degree in biology in Greenland - Polarjournal

Biology

On the water front: invasive lake species – UMN News

Some of the most destructive invasive species come in small packages. Few come smaller than the spiny water flea, a tiny crustacean with a long, spiked tail.

Spinies and the more famous zebra mussels change lake ecosystems far out of proportion to their size. At the University of Minnesota Twin Cities, Gretchen Hansen is untangling the web of biological and chemical impacts that these and other aquatic invasive species weave.

A lot of our research focuses on documenting impacts while also identifying places that are more sensitive or more resilient, says Hansen, an assistant professor in the Department of Fisheries, Wildlife and Conservation Biology. We also study climate change and how lakes and fish respond.

Spinies are part of the zooplanktontiny animals that drift around with tiny plants called phytoplankton. So are native water fleas, which are eaten by many young fish and, unfortunately, spinies. Spinies afflict lakes large and small, including Lake Mendota in Madison, Wisconsin, and Minnesotas Lake Mille Lacs.

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On the water front: invasive lake species - UMN News

Biology

Armenian students win eight medals at 4th International Applied Biology Olympiad Public Radio of Armenia – Public Radio of Armenia Official Web site

Armenian representatives won 2 gold, 5 silver and 1 bronze medals at the 4th International Applied Biology Olympiad (IABO) held on June 20-23 in Bali, Indonesia.

All eight students representing the three educational centers of Armenia won medals.

The Armenian team was led by Vahagn Gevorgyan, a biology teacher at Quantum college.

11th-grade student of Quantum College Aram Kerobyan and 10th-grade student of YSU STEM School Mariam Galstyan won gold medals. Silver medals were won by Ara Melkonyan and Hrachya Sevoyan, 11th grade students of Quantum College. Ani Gevorgyan, 9th grade student of Quantum College, Nane Ananikyan, 10th grade student of YSU STEM School, and 10th grade student of Hrazdan High School No. 10, Ellen Danielyan. Hayk Harutyunyan, a student of the 10th grade of Quantum College, won a bronze medal.

The students had previously participated in the online format and passed the preliminary two rounds and had the opportunity to participate in the final round.

More than 100 students from Armenia, US, Bangladesh, Indonesia, Thailand, Malaysia, Nepal and Philippines participated in the final round.

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Armenian students win eight medals at 4th International Applied Biology Olympiad Public Radio of Armenia - Public Radio of Armenia Official Web site

Biology

Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response … – Nature.com

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Biology

New tomato, potato family tree shows that fruit color and size evolved together – EurekAlert

image:

Fruits of plants in the genus Solanumare incredibly diverse in color and size. A new family tree of this genus, created by a team led by Penn State researchers, helps explain this striking diversity andhow the fruits might have evolved.

Credit: Joo Vitor Messeder / Penn State

UNIVERSITY PARK, Pa. Fruits of Solanum plants, a group in the nightshade family, are incredibly diverse, ranging from sizable red tomatoes and purple eggplants to the poisonous green berries on potato plants. A new and improved family tree of this group, produced by an international team led by researchers at Penn State, helps explain the striking diversity of fruit colors and sizes and how they might have evolved.

The team found that the size and color of fruits evolved together and that fruit-eating animals were like not the primary drivers of the fruits evolution, as had been previously thought. The study, published in the journal New Phytologist, may also provide insight into breeding agriculturally important plants with more desirable traits, the researchers said.

There are about 1,300 species in the genus Solanum, making it one of the most diverse plant genera in the world, said Joo Vitor Messeder, graduate student in ecology and biology in the Penn State Eberly College of Science and Huck Institutes for the Life Sciences and lead author of the paper. Since the 1970s and 80s, researchers have suggested that birds, bats and other fruit-eating animals have driven the evolution of fruits like those in Solanum. However, the importance of the evolutionary history of the plants has been underestimated or rarely considered when evaluating the diversification of fleshy fruits. To better test this hypothesis, we needed first to produce a more robust phylogeny, or family tree, of this plant group to improve our understanding of the relationships between species.

Plants in the genus Solanum produce fruits with a wide variety of sizes, colors and nutritional values. They can appear black, purple, red, green, yellow or orange and range in size from less than a quarter of an inch to as much as 8 inches, or 0.5 to 20 centimeters. In addition to agriculturally important plants, some plants in the group are cultivated for their ornamental flowers, and the fruits of many of these plants are eaten by humans and a large diversity of animals, including birds, bats, reptiles, primates and other land mammals.

The researchers collected samples of plants from across the world, including wild plants from Brazil, Peru and Puerto Rico and plants from botanical gardens, and sequenced their genes from RNA. They supplemented with previously collected samples and publicly available data, ultimately comparing the sequences of 1,786 genes from a total of 247 species to reconstruct the Solanum family tree. This included representatives from all 10 of the major clades the branches of the tree and 39 of 47 minor clades within the genus.

By using thousands of genes shared among species that effectively represented the entire genus, we significantly improved the Solanum family tree, making it the most comprehensive to date, said Messeder, who conducted the research in the lab of Hong Ma, Huck Chair in Plant Reproductive Development and Evolution and professor of biology at Penn State and a co-corresponding author of the paper. Recent advances in technology allowed us to use more genes than previous studies, which faced many challenges in resolving relationships between species and clades. This improved tree helps us understand when different fruit colors and sizes originated or how they changed as new plant species came about.

The researchers added considerable resolution of the smaller branches in the group that includes potatoes and tomatoes, as well as their closely and more distantly related wild species. The insights gained, the researchers said, could support crop improvement programs for these species and other crops in the genus.

If the closest wild relatives of important agricultural crops have desirable traits, it is possible to breed crops with those species or borrow their genes, for example to improve resistance to temperature or pests or to produce larger fruits or fruits of a certain color, Messeder said.

The researchers found that the color and size of Solanum fruits was fairly conserved over evolutionary history, meaning that closely related species tend to have similar fruits. The evolution of fruit color and size is also correlated, with changes in one trait often corresponding to changes in the other, leading fruits of certain colors to be bigger than fruits of other colors.

These results suggest that physiological and molecular mechanisms may play a role in keeping the evolution of fruit color and size tied together, Messeder said. While frugivores or animals that primarily eat fruit and seed dispersers may influence diversification, we need to consider all of the possibilities when studying how fruits became so diverse.

The researchers also clarified the origin and diversification timeline of this genus, in part by including recent information from the oldest nightshade family fossil from a different genus in the Nightshade family whose fossil was dated to about 52 million years ago and from particular genes that improved estimates of the length of evolutionary branches. The researchers dated the origin of Solanum to about 53.1 million years ago a full 30 million years earlier than prior estimates that were based on genes from other parts of the plant cell. This paints a new picture of the environment that might have shaped how these plants diversified into new groups and species.

The Earths environment changed dramatically during the 30 million years in terms of temperature, carbon dioxide in the atmosphere, geography and animal diversity, Messeder said. Now that we know when Solanum and its subgroups originated, we can think about the conditions that might have promoted the diversification of that group, as well as how other organisms might have played a role.

The team found that the earliest members of Solanum had medium-sized berries that remained green when ripe, and that green and yellow fruits of this group became more diverse around 14 million years ago. The researchers speculated that bats might have played a role in this diversification, given their similar evolutionary timeline and that they are the primary dispersers of modern green and yellow Solanum fruits. As new bat species arose and expanded where they were living during this time, they ate Solanum fruits and carried their seeds to new environments. Next, the researchers plan to explore how modern interactions between animals and the fruit they eat may shed light on the evolution of both groups as well as explore the evolution of certain genes relevant to fruit color and size.

In addition to Messeder and Ma, the research team includes Toms Carlo, professor of biology at Penn State; Guojin Zhang, postdoctoral researcher at Penn State at the time of the research; Juan David Tovar at the National Institute of Amazonian Research in Brazil; Csar Arana at the National University of San Marcos in Peru; and Jie Huang and Chien-Hsun Huang at Fudan University in China.

Funding from the Fulbright Commission, the CAPES Foundation in Brazil, the Penn State Department of Biology, the Hill Memorial Fund from the Pen State Eberly College of Science, the Association for Tropical Biology and Conservation, the U.S. National Science Foundation, the International Association for Plant Taxonomy and the Society of Herbarium Curators supported this research.

Experimental study

Not applicable

A highly resolved nuclear phylogeny uncovers strong phylogenetic conservatism and correlated evolution of fruit color and size in Solanum L.

27-May-2024

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New tomato, potato family tree shows that fruit color and size evolved together - EurekAlert

Endocrinology

Doctor Joins Medical Group’s Diabetes & Endocrinology Office in Waldorf – University of Maryland Medical System

The University of Maryland Charles Regional Medical Center, a member organization of the University of Maryland Medical System, is excited to announce the newest addition to its Diabetes and Endocrinology team, Tadele Worku Desalew, MD.

Working with our UM Charles Regional Medical Groups Diabetes and Endocrinology office in Waldorf, Dr. Desalew is now seeing patients to help treat a wide range of endocrine disorders affecting adults, with particular emphasis on thyroid issues and diabetes.

"We are fortunate to have a top-notch physician like Dr. Desalew join our endocrinology team in Waldorf. His diverse experience and compassionate nature will provide Charles County with the high-quality, personalized medical care that each patient in our community deserves," said Stephen Smith, MD, Chief Medical Officer for UM Charles Regional Medical Center.

Dr. Desalew had his residency and received his fellowship in endocrinology at Howard University. He has been practicing endocrinology for the last 10 years in the Mid-Atlantic region and has seen many different interesting and complex endocrine cases while gaining tremendous knowledge and experience from his practice.

I take a patient-centered approach where each patient is different and his or her treatment is approached based on his or her belief, cultural background, religious philosophy, family support and socio-economic status, said Dr. Desalew.

Originally from Ethiopia. Dr. Desalew is a member of the American Association of Clinical Endocrinology, American College of Endocrinology, American College of Lifestyle Medicine, the American Medical Association, and American College of Physicians.

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Doctor Joins Medical Group's Diabetes & Endocrinology Office in Waldorf - University of Maryland Medical System

Endocrinology

YPrime Research Reveals User-Centric eCOA Technologies as Key to Overcoming Challenges in Endocrinology … – GlobeNewswire

MALVERN, Pa., June 25, 2024 (GLOBE NEWSWIRE) -- YPrime, the leading pioneer in clinical trial technology, today released a comprehensive research report titled Endocrinology Clinical Trials: Advancing Research with the Help of eCOA Technologies. The report, based on a survey of clinical trial professionals specializing in endocrinology research, emphasizes the critical role of user-centric eCOA (electronic clinical outcome assessment) technologies in addressing the unique challenges faced by the industry.

The answers to several survey questions highlight the importance of patient-centricity in endocrinology clinical trials:

"At YPrime, we understand that every therapeutic area has its own unique challenges and requirements," said Mike Hughes, Chief Product Officer at YPrime. "By closely collaborating with patients, site staff, and sponsors, we develop eCOA solutions tailored to the specific needs of endocrinology trials. Our user-centric approach ensures that our technologies are not only cutting-edge but also intuitive and easy to use, ultimately leading to better patient engagement, higher data quality, and faster study timelines."

The report also highlights the growing adoption of connected devices in endocrinology clinical trials, with 44% of respondents already leveraging these technologies, primarily for at-home patient monitoring and another 46% considering adoption. In related news, YPrime recently announced the launch of its groundbreaking glucometer functionality, which integrates seamlessly with its eCOA platform. Developed in close collaboration with patients living with diabetes, this innovative feature promises to transform clinical trials with blood glucose endpoints by delivering a patient-centric, intuitive, and connected experience.

Please visit the YPrime website for the full version of Endocrinology Clinical Trials: Advancing Research with the Help of eCOA Technologies. The report offers valuable insights and practical recommendations for clinical trial professionals looking to optimize their endocrinology studies with the help of eCOA technologies.

About YPrime At YPrime, we streamline the clinical trial journey with a configurable platform designed for speed, quality, and certainty. With 50% faster IRT startup times, up to 30% faster eCOA launch times, and quality standards 50% above the industry average, YPrime can help you solve for certainty. Discover how by visitingwww.yprime.com or emailing marketing@yprime.com.

Media Contact Terry Rehm Head of Thought Leadership and Public Relations, YPrime trehm@yprime.com862-288-0329

Aninfographic accompanying this announcement is available at:https://www.globenewswire.com/NewsRoom/AttachmentNg/3a9e66f2-0df1-4529-a9b4-91994c1fda44

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YPrime Research Reveals User-Centric eCOA Technologies as Key to Overcoming Challenges in Endocrinology ... - GlobeNewswire