The Masochistic Merits of Sadness – The Wesleyan Argus

There is a scene, an admonition, that I have witnessed on television, in real life and in my head. Do not fetishize your sadness! says some agent of21st-century wisdom. I dont! replies some deviant in denial. It makes sense that we young people would encounter this. Young people, like most people, have sadness, and as a result of our unformed identities, we are faddy, stylish, hip and posturing. We exaggerate for the pleasure, fixate for meaning; In short, we are fetishizers for certain. So as a result, we have this scene, again and again:

Do not fetishize your sadness!

I dont!

Why doesnt the latter simply say So what!? Why is the fetishization of sadness assumed to be so reprehensible? How much of our repulsion to this fetish is based in rhetoric as opposed to substance?

I think that this question often goes unanswered. To fetishize sadness is bad; its simply common knowledge. As we do with so many ideas regarding mental health, we assume this statements truth. Yet, there is hope after all, because there is another assumed truth held in high regard by our socio-psychiatric dogma: Accept yourself. Are these two commonly held beliefs not antithetical? To love your sadness is to accept yourself, but to love your sadness is also to fetishize it.

Weve reached an impasse, and since these two beliefs are so commonly held, this impasse would seem almost universal. For all those indoctrinated into the common wisdoms of mob psychiatry, there is an ambitious industrialist, seeking to optimize sadness out of existence, and there is a hopeful determinist, who seeks to accept existence as it is discovered. To accept what degrades us is self-destructive, but to wage war on that which is essential is to erase our humanity. The contradiction is of mythic proportion, and it begs the question: What is essential to the human condition and what can change? What wins out: our acceptance of the self, or our hatred for our sadness?

Of course, this question is too impossible to be solved by an ignorant college student whose navet will be forever immortalized by the Wesleyan Argus archives. Nonetheless, Ill do my best.

It seems to me that acceptance ought to win out because, what is so bad about fetishizing sadness anyway? Well, a lot, I suppose. There is an undeniable toxicity when a person identifies with their misery to such an extent that it becomes their social grounding, when their pleasure of life is resultantly self-denied. But I believe that we can cut around these edges and find an acceptance of sadness that is beautiful. What is this joyful workaround? Masochism!

Masochism! Masochism! Masochism! I think that this word is viewed as meaning something quite specific, perhaps something sexual, definitely something perverse. I disagree. On the contrary, I believe that masochism describes a wide range of essential human behavior. Ambition is masochism. Moral aspirations are masochism. Watching the news nowadays is masochism. (And of course, wanting to get beaten in bed is also masochism.) My point is that so many masochisms are allowed and accepted, if not encouraged, by society. Why should I derive pleasure from my academic drive but not from my sadness, from my sense of civic duty but not from my existential ennui?

I love my sadness. I am fulfilled by it. As a musician, I seek to distill it, to elevate it, to celebrate it in all its glory. There is a masochistic merit to sadness, and this merit doesnt lie within the social performances, postures and fashions of which we are accused. This merit remains when we are alone. It exists in our consumption of sad movies, in the catharsis of a symbiotic and candid heart to heart, in the tears we shed for humankind. Someone might read this, and think,Wait a minute, what youre describing isnt a fetishization of sadness; its something altogether different. If this is the case, then good. I believe it to be a worthy substitute, the quinoa of sulking.

I write this opinion not as a sorry excuse for advice, but as an examination of a contradiction. Sadness, gloominess, misery, self-loathing, despondence [insert more synonyms here]they take many complicated and devastating forms and cannot possibly be holistically understood by the embryo that is mynascent 20-year-old mind. I dont doubt that Ill disagree with myself within five years and quite possibly within five days. Even so, I felt the desire to express these current views of mine; regardless of whether they are right or wrong, I believe that they are not adequately considered. Furthermore, I share because I believe the issue at hand to be all-pervasive in the world of my fellow young people. I hope that readers of this piece will analyze the complexity of their own pleasure in earnest. I hope that they will examine the potential difference between pleasure and happiness. I hope that they will reflect on what this potential difference means for them.

Matthew Rubenstein can be reached at mnrubenstein@wesleyan.edu.Matthew Rubenstein is a member of the class of 2021.

Here is the original post:
The Masochistic Merits of Sadness - The Wesleyan Argus

Eskenazi’s Lauren Daugherty integrates art, therapy and education – Indiana Daily Student

Lauren Daugherty stands Nov. 18 inside the education center in the Eskenazi Museum of Art. Daugherty is the new art therapist at the museum. Izzy Myszak Buy Photos

Lauren Daugherty knew she had a love for art while looking at a painting during a fourth grade field trip to the David Owlsey Museum of Art. Admiring the gigantic double doors, she imagined her own work being hung on the walls.

Yes, Daugherty knows this sounds particularly idyllic. Nonetheless, her work today pushes museum guests to capture their own feelings after looking at artwork through art making.

Lauren Daugherty is an arts based wellness experiences manager at the Sidney & Lois Eskenazi Museum of Art.

I usually just say Im an art therapist. It rolls off the tongue a bit easier, Daugherty said.

Daugherty received her masters degree at the Herron School of Art at Ball State University, writing her thesis on existing museums that collaborate with art therapists and art educators.

Now, she works as an art therapist in the educational center of the Eskenazi.

Daugherty is managing the first ever arts-based wellness center at the Eskenazi. This is a result of the recently finalized $30 million renovation of the museum.

Art therapy is an emerging field. In Indiana, only three universities, Ball State, the University of Indianapolis and St. Mary-of-the-Woods teach arts-based wellness.

Daugherty explained what art therapy looks like at the Eskenazi. She said each practitioner has a different way of providing services.

Were really interested in people finding their own connection with what theyre seeing, Daugherty said. Youre capitalizing on the magical feeling that people have when they come into a museum space.

A wellness-based activity engages guests with art making to relax and use a creative outlet. The next step would be to analyze the art, which then becomes a therapeutic activity.

Daugherty works with elementary-age kids to college students and older community members, looking at art and then returning to the art-making studio to express their feelings through artwork.

Working with such disparate age groups requires her to understand her audience at an individual level. For example, she knows that young children may not necessarily have the same capacities as adults in analyzing and interacting with artwork.

Instead, maintaining consistency from one session to the next is key, especially for kids who have experienced trauma and instability.

For example, she works with Monroe County Career Appointed Special Advocates in helping child survivors of abuse and neglect through art therapy.

Were trying to really know our audience and making sure were using clinical skills to inform what were doing even if it isnt super clinically-based, said Daugherty.

Some of her older clients have depression, anxiety, schizophrenia or psychosis. Other clients simply want to use the resource to destress and take time for themselves.

When Daugherty first began to learn about intersecting therapy with art, she always imagined it would be in a one-on-one, clinical office or at someones bedside.

After a few internships, she realized that she preferred group therapy over personal settings.

It decreases feelings of isolation, Daugherty said. Everything here is community-based.

Daugherty leads three different kinds of programs since the museums reopening in early November: wellness pop-ups, community sessions, and college student sessions.

She organizes wellness pop-ups where she visits different schools on campus, offering wellness activities for students to participate in between classes. They often occur at the Kelley School of Business.

From 1-2:30 p.m. on Thursdays, she opens the art-making room to the Bloomington community. Following that session, from 2:30-4 p.m., she welcomes college students.

When asked about challenges in managing the museums first few months of art therapy, Daugherty was hard-pressed to think of any. She said her director, Heidi Soylu-Davis, had a vision for the education program, and Daugherty has had her support since her hiring.

She identified one challenge.

Its being able to offer the amount of services that people are wanting, Daugherty said.

As an educational museum, the Eskenazi hires interns in many of its departments. Daughertys intern is Katy Bradberry, a graduate student at the Herron School of Art at Ball State.

Bradberry commented on her experiences working with Daugherty.

Its been a great experience here. I love working with Lauren, Bradberry said.

Eryn Ryan, the museums Tour and Docent Experiences Manager also spoke about her coworker. She has worked with Lauren for about six months.

Shes doing a great job forming personal experiences with our guests at our museum, Ryan said. Were very lucky to have her.

Moving forward, Daugherty has plenty of ideas for how the program can develop and serve more people. One idea is to create sensory tours, using 3-D printing technology to make replicas of pieces on display to better engage autistic and seeing-impaired guests.

Ultimately, Daugherty hopes to see art therapy grow as a field across the country.

Working at one of the countrys preeminent university museums as an art therapist offers great opportunity but also demands serious responsibility. Daugherty recognizes this, approaching her guests and activities alike with sensitivity and clinical research.

Daugherty has always been interested in art, art museums, and understanding human behavior. Working at the Eskenazi alongside a team of equally passionate workers has changed how she experiences museums, but nonetheless, her appreciation for her job is apparent.

Ive loved every second of it, Daugherty said.

Like what you're reading? Support independent, award-winning college journalism on this site. Donate here.

Ensembles from the Jacobs School of Music and the folklore and ethnomusicology department performed.

The seminal 2011 album from The Wonder Years is perfect for a gray November.

The featured speaker was IU English professor Ross Gay.

Follow this link:
Eskenazi's Lauren Daugherty integrates art, therapy and education - Indiana Daily Student

Motivational speaker talks overcoming disabilities in "Four Days with Kenny Tedford" – Johnson City Press (subscription)

Often mocked by classmates growing up, Tedford was born with brain damage that left him with the intellectual ability of afourth-grader. The damage also left him deaf, legally blind in one eye and with partial paralysis.

With the help of co-author Paul Smith, Tedford recently embarked on his latest book,Four Days With Kenny Tedford: Life Through the Eyes of a Child Trapped in a Partially Blind and Deaf Mans Body. The book, which will be released Nov. 26, discusses what its like to live with disabilities and explores Tedfords experiences with trauma.

I have spoken all around the United States, Canada and Norway. My audience varies, from preschoolers to senior citizens as old as 99 years. I have spoken to high school-age groups, college students, the Veterans Administration, churches and major state and international conventions of different occupations, such as interpreters, teachers, airlines, educators, etc. This experience has led me to write this book, Tedford, who has had to work to overcome difficulties speaking, wrote in an email to the Press.

Tedford who has worked as a counselor and former executive director of the TennesseeCouncil for the Deaf and Hard of Hearing recentlyreached out to the Press to tell us more about his book and himself, starting with some fast facts.

Tedford Briefly:

Hobbies: Hiking, horseback riding and kickboxing.

Favorite musicians: Bing Crosby, Frank Sinatra and Susan Boyle

Favorite food: Mexican food

Dogs or cats: Definitely dogs. Yellow Labs!

Ideal vacation: Being in a log cabin in the mountains with my hot tub and a cup of coffee. No one else is around, and spending time with God.

Can you tell our readers a bit more about your book?

My book is a collection of personal stories from my life. In it, I tell about my experiences with trauma and the loss of my family. The stories touch on how I overcame a broken neck, open-heart surgery, stroke, cancer, learning disabilities, and with the physical disability of deafness and depression. Overall, I hope the book will help others to see how they can also overcome any kind of trauma or obstacles. And I want to let them know that a person like me, labeled as mentally retarded, grew up to become a motivational speaker, actor, comedian, storyteller, and, now, a professor at East Tennessee State University. And, as a Christian, I give all the credit to God for everything and for who I am today.

What challenges did you experience growing up and how did you overcome them?

In addition to what I explained above, the biggest challenge that I had to overcome, even to this day, is communication with the hearing public. I overcome all challenges by my faith in God, and by living how Mom and Dad taught me, to just be myself, a loving son and loving to others.

What made you decide to write the book?

I have been told for the past 50 years, since high school, that I was a great storyteller, and a very funny comedian, and encouraged to write a book. It wasn't until I was performing my cancer story in Cincinnati, Ohio, at the National Storytelling Conference, when I was approached by a great writer, another motivational speaker, Paul Smith. He was very impressed and moved by my story, and was surprised that I didn't have a book with that story in it. He had already written four well-known books, and he decided to co-write a book with me. I hope that the audiences that I perform in front of will be able to have hope and never to give up, and to learn to love themselves as they are.

Do you think society is becoming more accommodating to people with disabilities?

I think, because of technology, that people are becoming more aware of those with disabilities around them. As for the deaf, I have seen some improvement, but there is still a long way to go. I say that because it is often difficult to get interpreters for hospital and doctor visits, etc. With technology, including video phones, text messaging, etc., we are being brought closer to access to hearing people. I pray that the book "Four Days with Kenny Tedford" will educate everyone, with or without a disability, and bring us together in unity with respect as individuals.

Who is your biggest inspiration in life?

I have two people that are famous who have been my inspirations, and role models, Abraham Lincoln, and Helen Keller.

Abraham Lincoln overcame a great deal of trauma and the death of loved ones in his life. Many people don't know this, but he was also depressed and suicidal. He ran for so many offices and lost, but this did not stop him from running again and becoming one of the greatest (to me) presidents of all. He shows me that one can overcome anything in life if you just persevere and not give up. He, too, had his personal faith in God that helped him. He was a very faithful man.

Helen Keller watching her life story in movies and reading about it in books, I see that she practically grew up as an animal with no education or any human behavior training. And yet, she became (to me), one of the most amazing motivational speakers I have ever seen, especially for a person who was deaf and blind. She also wrote many books.

View post:
Motivational speaker talks overcoming disabilities in "Four Days with Kenny Tedford" - Johnson City Press (subscription)

Michigan DNR said it killed wolves to protect humans. Then we got its emails. – Bridge Michigan

It was a DNR employee, furbearer specialist Adam Bump, who told Michigan Radio in May 2013 of wolf packs terrorizing Ironwood residents.

So you have wolves showing up in backyards, wolves showing up on porches, wolves staring at people through their sliding-glass doors when theyre pounding on it, exhibiting no fear, he said during the interview.

Never happened.

At least not in Michigan, as Bump would later acknowledge in recanting the story on air. He said he had mistakenly recounted an incident from a book he had read about human encounters with mountain lions in Colorado.

Warren, of the National Wolfwatcher Coalition, said she first heard casual talk of wolf attacks at the Dykstra farm in May 2016 as she listened to a country music station at her home in nearby Ewen.

Inquiries to the DNRs Marquette office that May 26 were met with a string of evasive responses, her correspondence shows. Warren persisted.

She filed a formal request for cattle-attack reports the next morning, Friday, May 27, 2016.

Warren didnt know it then, but the first of the three killings of the Ontonagon wolves had already taken place.

Under the Michigan Freedom of Information Act, government agencies are required to respond to public records requests within 5 business days, though a provision allows them a 10-day extension, which they routinely take.

At the end of that period, the agencys only obligation is to give a response, such as by sending a letter saying the records will (or will not) be provided.

Agencies are not required to actually provide the records within that time. In fact, one significant loophole in state law is that it provides no clear guidelines for when the records themselves must be turned over, which means that people seeking records often have to rely on the goodwill of the government worker in that office.

DNR charged Warren $87.50 for the records.

Nine weeks later, the agency turned over 35 pages on cattle attacks to Warren.

But when she looked at the papers sent by Chief Masons office, the names, addresses and contact information were blacked out, making it impossible to determine which farmers lost cattle to wolves. DNR also excluded geographic coordinates township, range and section numbers for farms that suffered livestock attacks.

Its not unusual for government offices to redact parts of a document. Generally, theyre allowed to block information if they can show it falls under one of several exemptions to public records, usually to protect someones privacy. The home address of a judge or police officer, for example, or the Social Security number of a party in a lawsuit are the kinds of information shielded from public release.

DNR sought to extend this same exemption to farms. Victoria Lischalk, Chief Masons executive assistant, wrote Warren that the location of livestock attacks was considered information of a personal nature (and) would constitute a clearly unwarranted invasion of privacy if released.

Warren found that argument preposterous. As a longtime wolf advocate who had helped the state develop its wolf management plan in 2008, she said there were plenty of times when shed received similar information within days.

So in November 2016 Warren hired an attorney to sue DNR, arguing that the location of reported wolf attacks were germane to the publics understanding of how the DNR handled wolf encounters, and outweighed any privacy concerns of farmers.

DNRs stonewalling, she argued, was an effort to retaliate against her for her outspoken opposition to wolf hunting.

In short, it appears that higher-level DNR officials have ended the friendly and informal relationship [Warren]had previously enjoyed, the suit said, and have instituted a policy of tight lips.

Lawsuits take time. It was not until May 2018, two years after Warren first sought the records, that Michigan Court of Claims Judge Cynthia Diane Stephens ruled in Warrens favor and ordered the public records released.

General geographic information describing where a wolf encountered livestock does not fit the definition of personal, Stephens wrote. Even assuming the information were personal, the balancing test would favor disclosure because the information reveals information about [DNRs]wolf-management policies.

The judge ordered DNR to pay $11,000 in fees and costs to Warrens lawyer, Rebecca Millican of Traverse City, to reimburse Warren for the cost of litigating the case.

The DNR documents released to Bridge add to evidence uncovered in earlier reporting I performed for The Detroit News that suggested DNR had bent to pressure from Casperson the pro-business, anti-wolf senator from Escanaba - to have the Ontonagon wolf pack killed.

As cattle losses mounted on the Dykstra farm in the spring of 2016, it was Casperson, the influential chairman of the Senates Natural Resources Committee, who intervened at the request of owner Tom Dykstra.

The senators 38th District covered the western U.P., including Ontonagon County and the Dykstra operation. Casperson who once wore a wolf-skin cap to celebrate a wolf-hunt victory was a strong proponent of reshaping the states conservation laws to make them more friendly to business, hunting and property interests.

Until term limits forced him from office last December, Casperson led the charge to allow the hunting of gray wolves in Michigan should they ever lose federal protection. When I interviewed him last fall, Casperson acknowledged he had called Terry Minzey, DNRs U.P. wildlife supervisor, after getting an earful from Tom Dykstra.

The rancher was angry that state and federal wildlife managers had captured and caged two of the wolves the day before, only to release them. The wildlife managers had hoped that harassing the wolves by caging them would scare them off.

Dykstra had lost like 14 calves and was sending regular pictures and it was just unacceptable, Casperson said of his decision to call DNR. You cant wipe out a guy's herd.

Reimbursing Dykstras farm for livestock losses was adding up, Casperson said, even as he acknowledged the wolves had no history of being aggressive around people.

The question became, Casperson said, who is going to go first? Who wants to take the first shot, so to speak? I think he (Minzey) understood someone had to go first.

Three days later, Minzey put his name to the memo describing the phantom wolf attack in front of Johnson.

Dykstra farm manager Duane Kolpack confirmed Caspersons assessment.

The decision to kill the wolves was kind of thrown together quick because the [animal]activists kind of frown on killing wolves when they are federally protected, Kolpack told me last year.

It was only after Casperson and Kolpack separately disclosed the wolf shootings that DNR acknowledged the killings, 2 years after they happened. Even then, the state still insists the packs aggressiveness in the presence of humans (and not their killing of livestock) prompted the decision.

Federal wildlife law permits the killing of protected gray wolves in defense of human life, or if wolves pose a demonstrable but non-immediate threat to human safety.

In seeking federal permission to shoot the wolves, DNR highlighted Johnsons purported encounter with the aggressive wolf at the Dykstra farm.

In one case, the wolf was sufficiently bold as to enter the pasture and kill a calf at the very moment one of our wildlife technicians was in the same field investigating a previous kill, Minzey, the wildlife supervisor, wrote to the federal government bolding and underlining the passage.

Curiously, in the version of this letter the department provided to me in 2018, DNR removed the bold and underlined emphasis used by Minzey in petitioning the feds.

Likewise, the department also withheld a portion of the U.S. response which indicated just how influential Minzeys account was in the federal governments approval of the wolf kills. That excised paragraph said:

It is clear that the wolves are acting aggressively including in the presence of humans as documented by the attack on livestock while the MDNR technician was in the same field, wrote Scott Hicks, regional U.S. Fish and Wildlife Service supervisor, in approving lethal action.

The emails released to Bridge show DNR pressed the same, discredited account involving Johnson to its own employees. On May 23, 2016, Mason told DNR staff:

This past week, for the first time ever, the U.S. Fish and Wildlife Service authorized the lethal removal of three wolves that showed persistently, brazen behavior by killing livestock in the presence of the operator and our staff.

Johnson declined comment for this article. Minzey, the supervisor who wrote the inaccurate report, did not return multiple emails and phone messages and DNR would not make him available for an interview. He remains with the department.

DNR spokesman Ed Golder describes Minzeys account as a communication breakdown. In an email earlier this year, Golder said Minzey had no clear recollection how he got the facts wrong about the 2016 wolf encounter.

But Golder also insists the decision to kill the Ontonagon wolves was not solely based on the Brad Johnson incident.

That single incident was one factor among others involved in drawing the conclusion that the wolves posed a non-immediate threat to human safety, Golder wrote Bridge.

He also noted that non-lethal measures had failed to keep the wolf pack from Dykstras cattle pastures.

Golder declined to elaborate, writing in March: We dont have anything to add to that account.

But Russ Mason did.

Mason was DNR wildlife chief for over a decade and was well known to hunters, with his sprawling command ranging from furry and feathered game to neurological illnesses like chronic wasting disease in zombie whitetails.

Last Nov. 30, Mason told me the Ontonagon wolf shootings were necessary to protect people.

The DNR, Mason said, is just as transparent as we can be with the number of wolves that have been [killed]. He released a three-page timeline purporting to set the record straight.

But Golder, the agency spokesman, acknowledged in an email a few months later that Mason knew the Brad Johnson wolf attack story was false prior to the time of your interview. Brian Roell, a DNR wildlife specialist, had told top officials what really happened two days before the interview. This was apparently the second time Roell had raised questions internally about the agencys description of the incident, email records obtained by Bridge show.

Go here to see the original:
Michigan DNR said it killed wolves to protect humans. Then we got its emails. - Bridge Michigan

World’s first ‘designer baby’ to be born in a year – IOL

London - The first "designer baby" conceived using a controversial screening technique is expected to be born next year.

An embryo has been implanted into a surrogate using IVF by US firm Genomic Prediction.

Nathan Treff, chief scientific officer at the New Jersey firm, told the Mail "there is now a pregnancy confirmed" and it is hoped the baby will be born in 2020.

It is understood the parents are a male couple in the US, who are having the baby using a surrogate mother.

The embryo has been selected through genetic sequencing to have a reduced risk of 11 diseases, including several types of cancer and diabetes. While such a test would be illegal in the UK, Genomic Prediction said it intends to apply for a licence with the watchdog Human Fertilisation and Embryology Authority.

Read more here:
World's first 'designer baby' to be born in a year - IOL

Professor will make ‘workhorse’ microscope more powerful – University of Wisconsin-Madison

Kevin Eliceiri, professor of medical physics and biomedical engineering at the University of WisconsinMadison, plans to improve the architecture and infrastructure of Manager, an open-source software package for control of automated microscopes.

Open-source software is crucial to modern scientific research for advancing biology and medicine while also providing reproducibility and transparency. Yet, even the most widely used research software often lacks dedicated funding.

Now, Eliceiri has received a $200,000 grant for his work from the Chan Zuckerberg Initiative. CZI awarded just 32 grants worldwide for 42 such projects.

Kevin Eliceiri works with a swept-field confocal microscope. This project is all about making the workhorse known as the microscope more powerful, says Eliceiri, a principal investigator in the Laboratory for Cell and Molecular Biology.

This project is all about making the workhorse known as the microscope more powerful, says Eliceiri, a principal investigator in the Laboratory for Cell and Molecular Biology in the Office of the Vice Chancellor for Research and Graduate Education, associate director of the McPherson Eye Research Institute, and investigator of the Morgridge Institute for Research. Open-source software not only enables unhindered adoption but importantly free adaptation, taking tools into new directions beyond their original intent.

Eliceiri uses Manager in his own research, which focuses on biophotonics, or the use of light to investigate biological phenomena, and on the application of computational techniques to analyze and process images of biological processes in real time.

Much of this informatics work entails development of the widely used open-source ImageJ software. Manager heavily relies on ImageJ for its functionality and Eliceiris CZI funding will benefit both software packages.

Software allows you to work with the full lifecycle of data how you acquire data, visualize it, analyze it and open-source software is all about accessibility and transparency, allowing scientists to freely try new approaches and understand precisely what was done in a study, Eliceiri says.

The CZI grant will also lead to enhanced data acquisition using Manager.

Not only can open-source software save time and resources, but it can directly lead to new innovation and discovery.

Kevin Eliceiri

When one thinks of how data is acquired, that often doesnt get as much attention as data analysis, Eliceiri says. Im interested in optimizing the settings of the microscope and improving how the hardware are talking to each other.

Eliceiri is using these tools to understand the role that the environment within a cell plays in disease progression.

Optical imaging is the tool of choice for understanding cellular phenomena with precise spatial and temporal accuracy, he adds.

Eliceiri says he has always believed that science is best done by building on the work of others and openly sharing what you have done.

Open-source software is the very embodiment of this concept, he says. Not only can open-source software save time and resources, but it can directly lead to new innovation and discovery.

Founded by Dr. Priscilla Chan and Mark Zuckerberg in 2015, CZI leverages technology to help solve some of the worlds toughest challenges, from eradicating disease to improving education and reforming the criminal justice system.

Other CZI funded projects include tools for visualizing, analyzing and managing data for research areas such as genomics, structural biology, cell biology, neuroscience and more.

Share via Facebook

Share via Twitter

Share via Linked In

Share via Email

Continued here:
Professor will make 'workhorse' microscope more powerful - University of Wisconsin-Madison

Major step taken in creating complex organs in the lab – Drug Target Review

A major step has been taken towards developing functional miniature versions of human organs in a Petri dish which can be used to shed light on the processes involved in the genesis of diseases.

Scientists from the University of Wrzburg, Germany have taken a major step towards developing functional miniature versions of human organs, known as complex organoids.

Japanese researchers had previously developed a way of creating pluripotent stem cells through epigenetic reprogramming of connective tissue cells, which has yielded a highly valuable cell type that can be used to grow all cells of the human body in a Petri dish.

When culturing these so-called induced pluripotent stem cells (iPS cells) as three-dimensional (3D) cell aggregates, the organoids can be created by selectively adding growth factors.

Such organoid models are often similar to real embryonic tissues. However, most remained incomplete because they lacked stromal cells and structures, the supportive framework of an organ composed of connective tissue.

This new development was part of a project led by Dr Philipp Wrsdrfer and Professor Sleyman Ergn, the head of the Institute of Anatomy and Cell Biology, which has resulted in organoids that have complexity similar to that of normal tissue and are far superior to previous structures.

Organoid models are often surprisingly similar to real embryonic tissues. Shown here (from left): 3D reconstruction of the vascular network within an organoid, brain organoid with blood vessels (red) and brain stem cells (green) and a tumour organoid with blood vessels (red) and tumour cells (green) (credit: Institute for Anatomy and Cell Biology).

We used a trick to achieve our goal, explained Philipp Wrsdrfer. First we created so-called mesodermal progenitor cells from pluripotent stem cells. Under the right conditions, such progenitor cells are capable of producing blood vessels, immune cells and connective tissue cells.

To demonstrate the potential of the mesodermal progenitor cells, the scientists mixed these cells with tumour cells and brain stem cells that had previously been generated from human iPS cells. This mixture grew to form complex 3D tumour or brain organoids in the Petri dish featuring functional blood vessels, connective tissue, and in the case of the brain tissue, brain-specific immune cells.

In the future, the miniature organ models generated with this new technique can help scientists shed light on the processes involved in the genesis of diseases and to analyse the effect of therapeutic substances in more detail before using them on animals and human patients, added Sleyman Ergn.

This would allow the number of animal experiments to be reduced. Moreover, the organ models could contribute to gaining a better understanding of embryonic development processes and grow tissue that can be transplanted efficiently.

The project was published Scientific Reports.

Read this article:
Major step taken in creating complex organs in the lab - Drug Target Review

Geneticists Attempt To Help Chemotherapy Patients Could End Age-Related Hair Loss, Wrinkled Skin And Reduced Energy – Forbes

A University of Alabama cancer geneticist is taking his anti-aging research to the next level to effectively end age-related hair loss, wrinkled skin and reduced energy. And he hopes to have products on the market in 5 years.

A new startup out of the University of Alabama at Birmingham (UAB), Yuva Biosciences, is essentially the result of Keshav Singhs attempt to help chemotherapy patients re-grow the hair they lose as a result of the cancer treatment. But what he found could help everyone.

Cropped composite image of a woman when she was young and old

Yuvawhich means youth in Hindihopes to tap into the multi-billion-dollar hair loss prevention and anti-aging skincare market with cosmeceuticals, science-based cosmetics and pharmaceuticals based on its founders research into mitochondrial DNAthe tiny part of cells that produce 90 percent of the chemical energy they need to survive.

Singh said along with causing skin to age and hair to fall out, mitochondrial dysfunction can drive age-related diseases. A depletion of the DNA in mitochondria is also implicated in human mitochondrial diseases, cardiovascular disease, diabetes, age-associated neurological disorders and cancer.

Last year, Singh and his colleagues at UAB reversed wrinkles and restored hair growth in mice. The team triggered a gene mutation that caused mitochondrial dysfunction in mice, causing them to develop wrinkled skin and lose their hair. The UAB researchers discovered that turning off that mutation restored the mice to normal appearance making them indistinguishable from healthy mice of the same age. In effect, when the mitochondrial function was restored, the mice regained smooth skin and thick fur.

The mouse in the center photo shows aging-associated skin wrinkles and hair loss after two months of ... [+] mitochondrial DNA depletion. That same mouse, right, shows reversal of wrinkles and hair loss one month later, after mitochondrial DNA replication was resumed. The mouse on the left is a normal control, for comparison.

Singh along with Bhupendra Singh, Trenton R. Schoeb and Prachi Bajpai, UAB Department of Genetics; and Andrzej Slominski, UAB Department of Dermatology shared their results in apaperin July 2018, Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function, in the Cell Death and Disease, a the online journal, Nature. The work was supported by U.S. Department of Veterans Affairs (VA) and National Institutes of Health (NIH) grants.

Now in addition to his duties as a senior scientist in the Cancer Cell Biology Program and director of the Cancer Genetics Program at the UAB Comprehensive Cancer Center, Singh will serve as chief scientific advisor for Yuva Biosciences.

Keshav Singh, Ph.D., cancer geneticist and chief scientific advisor for Yuva Biosciences

The founding editor-in-chief of Elseviers Mitochondrion journal, Singh said scientists already knew that humans age as mitochondrial DNA content and mitochondrial function decline. He said the trick is to find a way to restore that content and function. And theyve already done that in mice. Now they want to transfer those studies and hopefully similar results to human trials.

Our plan is to look for two things, Singh said. We want to identify natural products which can enhance mitochondrial function. We have already identified at least one of these natural products that enhances mitochondrial function and also seems to prevent hair loss and wrinkles. Secondly, we want to re-purpose drugs that are already FDA-approved.

Singh said the National Institutes of Health (NIH) and the Food and Drug Administration (FDA) already has a library of thousands of FDA-approved compoundsdrugs for everything from diabetes to Alzheimers disease. We want to test them to see which ones might enhance mitochondrial function and even enhance energy, he said, adding that researchers work last year at UAB allowed us to develop a system where we can use different compounds that could enhance mitochondrial function.

Singh said the first of Yuvas products will likely be a topical therapy to halt wrinkles and hair loss and perhaps restore damage already done.

Yuva Biosciences plans to prevent or undo many of the effects of aging, which is why we like to say our goal is to provide Youthfulness for LifeTM, Singh said. Currently, we are aiming to develop productsto help people look and feel younger. Ourlong-term plan is to increase health span by addressing diseases associated with aging.

With the help of Greg Schmergel, a Boston-based serial entrepreneur, who will serve as chairman of Yuva Biosciences, Singh and four researchersincluding Robert K. Naviaux, MD. Ph.D. and Matt R. Kaeberlein, Ph.D.will occupy lab space at Innovation Depot, Inc. The Depot is a 140,000-square-foot office, lab and co-working startup space for technology companies located near UAB in Birmingham, Alabama. Yuva plans to hire two additional employees early next year.

Schmergel brings more than 25 years of experience in launching multiple high-tech ventures and leading a Massachusetts-based nanotechnology company, Nantero Inc., where he is the co-founder and CEO. A former senior vice president of corporate strategy for About, Inc., Schmergel also serves on the Board of Trustees of Lahey Hospital & Medical Centera, a physician-led nonprofit teaching hospital of Tufts University School of Medicine (TUSM) based in Burlington, Massachusetts.

In a statement, Schmergel said Yuva is committed to building the company in Birmingham, where well have access to resources like the world-class researchers and facilities at UAB, the startup-focused amenities at Innovation Depot, and the rising regional entrepreneurial network.

Kaeberlein specializes in aging and is past president of the American Aging Association, and professor in the Department of Pathology at the University of Washington (UW), in Seattle. Naviaux specializes in mitochondrial and metabolic medicine and is a professor of Genetics at the University of California San Diego (UCSD). Both scientists will serve on the Yuva Biosciences Advisory Board.

Singh said there is no telling how far Yuva could go in aging research, though there is much testing yet to be done. We have discovered that mitochondria, which are the powerhouse of the cell, are the reversible regulator of wrinkles and hair loss, Singh said. The potential is huge as everyone develops wrinkles and most of us lose hair. So, any agent or drug which can slow down or reverse that will have a major impact.

Singh wouldnt speculate on whether manipulating mitochondrial DNA could cause all human organs and systems to regenerate and whether it would reverse aging in themfor example the human brain and any implications his research could have on dementia. And although little change was seen in other organs when the mutation was induced, he did hint that there is indeed great potential for further disease research.

Go here to read the rest:
Geneticists Attempt To Help Chemotherapy Patients Could End Age-Related Hair Loss, Wrinkled Skin And Reduced Energy - Forbes

With Cell-By-Cell Take on Drug Discovery, Immunitas Debuts With $39M – Xconomy

XconomyBoston

A cancer tumor is a veritable patchwork of cells with a variety of genetic fingerprints.

Immunitas Therapeutics is using single-cell genomicsan approach that studies the genetic activity of individual cellsto peer deeply into patient tumors and more precisely determine what is fueling the growth.

With that knowledge, the company plans to develop new targets for treating forms of the disease based on what it learns about the interactions between immune cells and cancer cells around tumors.

Now the Boston company has raised $39 million to advance compounds discovered with its computational platform into human testing by the end of 2022.

The startup was founded by venture capital firm Longwood Fund, itself started about a decade ago by a trio of biotechies who worked together at Sirtris Pharmaceuticals through its 2008 acquisition for $720 million by British drug giant GlaxoSmithKline (NYSE: GSK).

Lea Hachigian, a Longwood principal, is president of Immunitas. She told Xconomy that Longwood found out about the platform, which had been developed and in use in the labs of its scientific cofounders for about three years, this winter.

The progress it had madeImmunitas already has multiple potential monoclonal antibody treatments in its pipelineprompted the venture firm to turn the tech into a company.

Treatments for cancer based on the genetic signature of a tumor, known as checkpoint inhibitors, have been able to help many cancer patients who previously had few options for treatment. But those treatments are only relevant for about 15 percent to 20 percent of cancer patients, Hachigian says.

Combination approaches, in which drug developers mix and match some of those therapies, havent proven to be a panacea either.

Those approaches are exciting, but they have been limited so far in what theyve yielded in the clinic in terms of efficacy, she says.

There a bunch of patients who havent been able to benefit from some of these treatments, she saysand those are the people for whom Immunitas is aiming to develop new treatments.

It plans to analyze cells from specific patient subgroups, such as people with a well-defined form of a disease or those who have developed resistance to a certain kind of treatment. The companys technology has also led it to identify biomarkers that it intends to use to guide its selection of patients for clinical trials. The idea is that a drug developed from those samples would be targeted at that group.

It is also looking to set itself apart from other drug discovery efforts by analyzing human samples, avoiding the misleading signals that can be sent by animal tests.

Single cell genomics pioneer Aviv Regev, a computational biologist and core member of the Broad Institute of MIT and Harvard, was an early collaborator on the project.

Hachigian likened the platform to noise-canceling headphones for tumor biology in how it allows researchers to hone in on drivers of tumor progression.

The companys lead program is designed around a target Immunitas discovered by studying a tumor that is resistant to an existing treatment. Since then it has determined the target is overexpressed in other tumor types, too, both liquid and solid.

Hachigian says the companys deep immunology expertise also set it apart from others using single-cell genomics to find cancer drugs. One of its scientific founders, Kai Wucherpfennig, heads the Dana-Farber Cancer Institutes department of cancer immunology and virology. (Its others are Mario Suv, a physician-scientist in the department of pathology at Massachusetts General Hospital; and MITs Dane Wittrup, the Carbon P. Dubbs Professor in Chemical Engineering and Biological Engineering.)

Immunitas isnt the only startup thats looking cell by cell in hopes of making new biological discoveries that lead to treatments. Regev, in fact, is a co-founder of Cambridge, MA-based Celsius Therapeutics, another new company using single cell genomics to advance its drug discovery efforts.

Celsius launched last year with $65 million in Series A funding led by Third Rock Ventures.

In addition to Longwood, two big pharma companies are among Immunitass biggest backers. Its Series A was led by Leaps by Bayer and Novartis Venture Fund, those companies respective venture arms. Other institutional investors in the round include Evotec, M Ventures, and Alexandria Venture Investments.

The company has five full-time employees and is based in BioLabs, an incubator in Kendall Square. By the end of next year, it plans to have added another 10 or so. And the following year, when it projects it will move into human testing, Immunitas plans to tack on perhaps another 10 more employees to fuel its clinical development efforts.

Sarah de Crescenzo is an Xconomy editor based in San Diego. You can reach her at sdecrescenzo@xconomy.com.

Read the original here:
With Cell-By-Cell Take on Drug Discovery, Immunitas Debuts With $39M - Xconomy

Junior Research Fellow for Stem Cell-Based Neural Tissue Engineering Project job with VELLORE INSTITUTE OF TECHNOLOGY | 187070 – Times Higher…

Job Description

Junior Research Fellow (JRF)for Translational Research - Stem Cell-based Neural Tissue Engineering Project:

Title of the Project: Human dental pulp stem cells as a multifaceted tool for accelerating neural regenerationDuration: 3 YearsLocation: Vellore Institute of Technology, Vellore

Qualification:

M.Sc/ M. Tech (Biomaterials, Tissue Engineering, Biotechnology, Biology, and Biomedical Sciences) with a minimum of 55% marks.

Skill set required:

Candidate with work experience in biomaterial synthesis, scaffold fabrication and stem cell culture is desirable.

Stipend: Rs.20,000/- per month (consolidated)

Work functions of the JRF: The JRF will be required to do full time research related to this specific project, in particular biomaterial synthesis and characterization, scaffold fabrication, biological assays, dental stem cell culture.

Principal Investigator:

Dr.Murugan RamalingamCentre for Biomaterials, Cellular and Molecular Theranostics (CBCMT)School of Mechanical EngineeringVellore Institute of Technology (VIT),Vellore 632014

Send your resume along with relevant documents pertaining to the details of qualifications, experience and latest passport size photo on or before (30/11/2019) through online http://careers.vit.ac.in.

No TA and DA will be paid for appearing for the interview.

Shortlisted candidates will be called for an interview at a later date which will be intimated by email.

Salary:Not Disclosed by RecruiterIndustry:Education / Teaching / TrainingFunctional Area:Teaching, Education, Training, CounsellingRole:Trainee

Keyskills

stem cellsbiotechnologybiologybiomaterials

Desired Candidate Profile

Please refer to the Job description above

Education-

UG:B.Tech/B.E. - Bio-Chemistry/Bio-Technology, Biomedical, B.Sc - BiologyPG:M.Tech - Bio-Chemistry/Bio-Technology, Biomedical, MS/M.Sc(Science) - Biotechnology, Biology

Company Profile

Vellore Institute of Technology

VIT was established with the aim of providing quality higher education on par with international standards. It persistently seeks and adopts innovative methods to improve the quality of higher education on a consistent basis.The campus has a cosmopolitan atmosphere with students from all corners of the globe. Experienced and learned teachers are strongly encouraged to nurture the students.

See the original post here:
Junior Research Fellow for Stem Cell-Based Neural Tissue Engineering Project job with VELLORE INSTITUTE OF TECHNOLOGY | 187070 - Times Higher...